CLUSTAL W (1.83) multiple sequence alignment CkIalpha_Dmel MDKMRI--------LKE-SRPEIIV-GG---KYRVIRKIGSGSFGDIYLGMSIQSGEEVA CG7094_Dmel MAKQEATNGK-VRNAS-LHLEKLLI-GG---KYRLVKPIGSGSFGDIYLGLSITDGSEVA C03C10.1_Cele MAGVM-------------SVKDFIV-AT---KYKLIRKIGSGSFGDIYVSINVTNGEEVA CK1a1_Spur MSAAPSAAGMHSACQSG-RSGEFIV-GSDKYKYRLVRKIGSGSFGDIYLGINIHNGEEVA CK1a2_Spur MSSAG---------SQG-QKPEYLVGGG---KYKLVRKIGSGSFGDIYLGINVGNGEEIA CK1a_Mmus MASSS-----------G-SKAEFIV-GG---KYKLVRKIGSGSFGDIYLAINITNGEEVA CK1a_Hsap MASSS-----------G-SKAEFIV-GG---KYKLVRKIGSGSFGDIYLAINITNGEEVA CK1a2_Hsap MTNNS-----------G-SKAELVV-GG---KYKLVRKIGSGSFGDVYLGITTTNGEDVA AqueK088_Aque MAASTG--------SSGSSKSEFTV-GG---RYRLVRKIGSGSFGDIYLGVNQTNGEEVA * . : . :*:::: ********:*:.:. .*.::* CkIalpha_Dmel IKMESAHARHPQLLYEAKLYRILSGGVGFPRIRHHGKEKNFNTLVMDLLGPSLEDLFNFC CG7094_Dmel IKVEKNDAKYPQLIYEAKVYEQLARCPGFPTLLHYGCEKNYNAMVMDLLGPSLEELFNLC C03C10.1_Cele IKLESNRARHPQLLYESKVYRILQGGVGIPHIRWYGTEREYNVLVMDLLGPSLEDLFNFC CK1a1_Spur VKLESEKARHPQLLYESKLYKILHGGPGIPTMKWFGQGHDYNIMVMELLGPSLEDLFNFC CK1a2_Spur VKMESAKARHPQLNYEGKVYRILQGGVGIPKIRWYGSEKDYNVLVMELLGPSLEDLFNFC CK1a_Mmus VKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFC CK1a_Hsap VKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFC CK1a2_Hsap VKLESQKVKHPQLLYESKLYTILQGGVGIPHMHWYGQEKDNNVLVMDLLGPSLEDLFNFC AqueK088_Aque VKLESHKARHPQLLYESKLYKILQGGVGIPHIKWYGSEKEYNVLVMDLLGPSLEDLFNFC :*:*. .::*** **.*:* * *:* : .* :: * :**:*******:***:* CkIalpha_Dmel TRHFTIKTVLMLVDQMIGRLEYIHLKCFIHRDIKPDNFLMGIGRHCNK------------ CG7094_Dmel KRRFSLKTVLMLTDQLLMRIECVHERGFIHRDIKPDNFLMGLDRHCNK------------ C03C10.1_Cele SRRFTMKTVLMLADQMIGRIEYVHVKNFIHRDIKPDNFLMGIGRHCNK------------ CK1a1_Spur SRKFTMKTVLMLADQMIARIEYVHVKNFIHRDIKPDNFLMGIGRHCNQ------------ CK1a2_Spur DRQFSMKTVLMLADQMLGRIEYVHNKNFIHRDIKPDNFLMGIGRHCNQ------------ CK1a_Mmus SRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRS CK1a_Hsap SRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRS CK1a2_Hsap SRRFTMKTVLMLADQMISRIEYVHTKNFLHRDIKPDNFLMGTGRHCNK------------ AqueK088_Aque SRRFTMKTVLMLADQMIGRIEYVHNKNFIHRDIKPDNFLMGIGRHCNK------------ *:*::******.**:: *:* :* : *:************ .****: CkIalpha_Dmel ----------------LFLIDFGLAKKFRDPHTRHHIVYREDKNLTGTARYASINAHLGI CG7094_Dmel ----------------LYLIDFGLSKRYKDIESEIHIPYRTDRNLTGTVRYASINAQIGV C03C10.1_Cele ----------------LFLIDFGLAKKYRDSRTRTHIPYREDKNLTGTARYASINAHLGI CK1a1_Spur ----------------LFLIDFGLAKKFKDSRSKQHIQYREDKNLTGTARYASINAHLGI CK1a2_Spur ----------------VFIIDFGLAKKYRDSRTRQHIPYKDDKNLTGTARYASIHAHQGI CK1a_Mmus MTVSPSQDPSFSGLNQLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGI CK1a_Hsap MTVSTSQDPSFSGLNQLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGI CK1a2_Hsap ----------------LFLIDFGLAKKYRDNRTRQHIPYREDKHLIGTVRYASINAHLGI AqueK088_Aque ----------------LFIIDFGLAKKYRDTRSKQHIPYREDKNLTGTARYASINAHLGI :::*****:*:::* .:. ** *: *::* **.*****:*: *: CkIalpha_Dmel EQSRRDDMESLGYVMMYFNRGVLPWQGMKANTKQQKYEKISEKKMSTPIEVLCKGSPAEF CG7094_Dmel EQSRRDDMESMSYCLMYFNLGKLPWQGITAANKKQKYEKILEKKTSVTIAQLCKGFPSEF C03C10.1_Cele EQSRRDDMESLGYVLMYFNRGTLPWQGLKAATKKQKYEKISEKKMTTSVEHLCKGFPAEF CK1a1_Spur EQSRRDDLESLGYVLMYFNRTSLPWQGMKAMTKKQKYEKISEKKMSTPVEVLCKGFPAEF CK1a2_Spur EQARRDDLESLGYVMMYFNRRSLPWQGLKAATKKQKYEKISEKKMSTSPETLCKSFPAEF CK1a_Mmus EQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEF CK1a_Hsap EQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEF CK1a2_Hsap EQSRRDDMESLGYVFMYFNRTSLPWQGLRAMTKKQKYEKISEKKMSTPVEVLCKGFPAEF AqueK088_Aque EQSYRHVLSSH--------------FDLIAATKKQKYEKISEKKLSTPIEILCKGFPAEF **: *. :.* .: * .*:****** *** :.. ***. *:** CkIalpha_Dmel SMYLNYCRSLRFEEQPDYMYLRQLFRILFRTLNHQYDYIYDWTMLKQKTHQGQPNPAILL CG7094_Dmel CLLMTYVRNLGFKEPPDHTYLRQIFRILFRSLNHHYDYIYDWTALQQQKDQICRSREQIL C03C10.1_Cele PMYLSYTRGLRFDESPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAQQS-QSSGVPG CK1a1_Spur AMYLNYARGLRFDENPDYVYLRQLFRILFRTLNHQYDFTFDWTLLKQKVTQQSAQTSVSN CK1a2_Spur AMYLKYCKNMKFEEAPDYMYLRQLFRILFRTLNYQYDYVFDWTLLKQKAANQAAALNNPS CK1a_Mmus AMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQG CK1a_Hsap AMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQG CK1a2_Hsap AMYLNYCRGLRFEEVPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQG AqueK088_Aque AMYLNYCRGLRFEESPDYMYLRQLFRILFRTLNHQYDYTFDWTLLKQKAAASTSSSSTVP : :.* :.: *.* **: ****:******:**::**: :*** *:*: CkIalpha_Dmel EQLD---------------KDKEKQN-------------------------------GKP CG7094_Dmel ESEREEVRKRDGERGCEPQRDKERHKDLELDRLHKTSTQQAKCSNGHLTNRYDRIGDGGI C03C10.1_Cele TNTTTQGAT---------VP-----------------------SAG----VPAGVA-PGG CK1a1_Spur -GVNPGTAK---------HS-ES-----------------------------------RS CK1a2_Spur KVSANPGGT---------LNNPSKGSAN-QFTLAQTPHDQMQHANH-HYRHLQRMS-ESK CK1a_Mmus QQAQTPTGK---------QTDKT----------------------------------KSN CK1a_Hsap QQAQTPTGK---------QTDKT----------------------------------KSN CK1a2_Hsap QQAQTQTGK---------QTEKN----------------------------------KNN AqueK088_Aque AGPTAIDDK---------RD-DKRDDGH-----------------G--MGGRLHGG-VPG CkIalpha_Dmel LIAD CG7094_Dmel SKRK C03C10.1_Cele TTPQ CK1a1_Spur KSKR CK1a2_Spur KSKP CK1a_Mmus MKGF CK1a_Hsap MKGF CK1a2_Hsap VKDN AqueK088_Aque PKKR