CLUSTAL W (1.83) multiple sequence alignment CG7597_Dmel MHASSA-------------A---ATALVEYSDVSSEDFSDQEAGDLDADAGKG-AGN--- CRK7_Mmus MPNSER-------------H---GGKK-----------------------DGSGGASGTS CHED_Mmus MPSSSD-------------T---ALGG-----------------------GG---GL--S B0285.1_Cele MEISPG-------------S---STHE-----------------------RDRKGSY--G CTK1_Scer MSYNNG-------------N---TYSK--------------------------------S CRK7_Hsap MPNSER-------------H---GGKK-----------------------DGSGGASGTL CHED_Hsap MPSSSD-------------T---ALGG-----------------------GG---GL--S DDB0229428_Ddis MDTTTN-------------N---NIEN--------------------------------- DDB0229428_C2d_Ddis MDTTTN-------------N---NIEN--------------------------------- 11773_Tthe MEKNSN-------------S---QQSG--------------------------------- CRK7_Spur MPGNHK-------------N---RGG-----------------------------SP--- CC1G_14638_Ccin MLRSRS-------------P---EGDQ-----------------------------M--G AqueK102_Aque MAAKLLLECCRKEAVPSFPPSFFPTGS-----------------------------L--S CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe MGCICA-------------K---SSST--------------------------------- CRK7_e_Smoe MGVSEG-------------G---EILS--------------------------------- CRK7_b_Smoe ------------------------------------------------------------ CRK7_d_Smoe MGVSEG-------------G---EILS--------------------------------- CG7597_Dmel ---------------------------------------------IKKPKPAPDN-QFS- CRK7_Mmus QPSSGGGSSNSR-----------ERHRLVSKH---------------------------- CHED_Mmus -W-AEKKLEERR-----------KRRRFLSPQQPPLLLPLLQPQLLQPPPPPPPL-LFL- B0285.1_Cele -H-RERTRSHSG-----------SPSRFYSKDK--------------------------- CTK1_Scer -Y-S-----RNN-----------KR-PLFGKRSPN-------PQSL-------------- CRK7_Hsap QPSSGGGSSNSR-----------ERHRLVSKH---------------------------- CHED_Hsap -W-AEKKLEERR-----------KRRRFLSPQQPPLLLPLLQPQLLQPPPPPPPL-LFL- DDB0229428_Ddis ------NTTENI-----------KKEEILEKQQHE------------------------- DDB0229428_C2d_Ddis ------NTTENI-----------KKEEILEKQQHE------------------------- 11773_Tthe ------SQTVP------------------------------------------------- CRK7_Spur ------------------------------------------------------------ CC1G_14638_Ccin -W-LPP---RD------------------------------------------------- AqueK102_Aque -W-STD---DRISLVCSDVIYVITL-KGFLPQNTKSLVPIS-VAIIEAPPMSFPLSLNLS CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe --------SR-------------------------------------------------- CRK7_e_Smoe ------Q----------------------------------------------------- CRK7_b_Smoe ------------------------------------------------------------ CRK7_d_Smoe ------Q----------------------------------------------------- CG7597_Dmel ---------------KGRLDAKPD-KE------------------GYDNYRSRR------ CRK7_Mmus ------------------------------------------------------------ CHED_Mmus -----------------------------------------------------A------ B0285.1_Cele ------------------------------------------------------------ CTK1_Scer ------------------------------------------------------------ CRK7_Hsap ------------------------------------------------------------ CHED_Hsap -----------------------------------------------------A------ DDB0229428_Ddis ------------------------------------------------------------ DDB0229428_C2d_Ddis ------------------------------------------------------------ 11773_Tthe ------------------------------------------------------------ CRK7_Spur ------------------------------------------------------------ CC1G_14638_Ccin ----------------------------------------------------EDRM---- AqueK102_Aque LDISKCIYGEHTPSNEGH---SPFNEGPLVDGVFGVLFDPLVSGCG-----SKGRFLSAK CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe ------------------------------------------------------------ CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe ------------------------------------------------------------ CRK7_d_Smoe ------------------------------------------------------------ CG7597_Dmel -----AEDSSDPVAAGSRQTSSS------------------------------------E CRK7_Mmus ------------------------------------------------------------ CHED_Mmus -----APGAAAAAAAAAAASSSC------------------------------------F B0285.1_Cele ------------------------------------------------------------ CTK1_Scer ------------------------------------------------------------ CRK7_Hsap ------------------------------------------------------------ CHED_Hsap -----APGTAAAAAAAAAASSSC------------------------------------F DDB0229428_Ddis ------------------------------------------------------------ DDB0229428_C2d_Ddis ------------------------------------------------------------ 11773_Tthe ------------------------------------------------------------ CRK7_Spur ------------------------------------------------------------ CC1G_14638_Ccin ------------------------------------------------------------ AqueK102_Aque WSPIRSNWSNRCILAGLTNSSSVLVYDETTRGQWDLVFDFTDIYYRVLVSVDFDVKLLPA CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe ------------------------------------------------------------ CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe ------------------------------------------------------------ CRK7_d_Smoe ------------------------------------------------------------ CG7597_Dmel ATNPREEPSQASNTSKDELWGREIYMSSDSIDT--------------------------- CRK7_Mmus ------------------------------------------------------------ CHED_Mmus SPGP---PL--------------------------------------------------- B0285.1_Cele ------------------------------------------------------------ CTK1_Scer --ARPPPP-KRIR-TD-------------------------------------------- CRK7_Hsap ------------------------------------------------------------ CHED_Hsap SPGP---PL--------------------------------------------------- DDB0229428_Ddis ------------------------------------------------------------ DDB0229428_C2d_Ddis ------------------------------------------------------------ 11773_Tthe ------------------------------------------------------------ CRK7_Spur ---------TYYHEHKDS------------------------------------------ CC1G_14638_Ccin -VSRSPSPGYRRRS--PSTSDRSS--------H--------------------------- AqueK102_Aque TSEQSPPPTTKTNISQSEYQRRRD--------FFVSVAMSWLPVFLSEGVVLLAIAMRSG CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe ---------S-------------------------------------------------- CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe ------------------------------------------------------------ CRK7_d_Smoe ------------------------------------------------------------ CG7597_Dmel -------------------------DELEAEMKRQKRKKQKKEK-HKHKSKKKSKKRKKK CRK7_Mmus ---------------------------------------------KRHKSKHSKDV---- CHED_Mmus ------------------------------EVKRLAR--GKRRPGGRQKRRRGPRA---- B0285.1_Cele ------------------------------------R--GSSRQGVRPRDRDSKDS---- CTK1_Scer ------------------------------------------------------------ CRK7_Hsap ---------------------------------------------KRHKSKHSKDM---- CHED_Hsap ------------------------------EVKRLAR--GKRRAGGRQKRRRGPRA---- DDB0229428_Ddis ------------------------------------------------AIKEESTTIKE- DDB0229428_C2d_Ddis ------------------------------------------------AIKEESTTIKE- 11773_Tthe ------------------------------------------------------------ CRK7_Spur ---------------------------------PSKRKHAKSSKSGRHKSKRSRDKVKE- CC1G_14638_Ccin -------------------------RSR-------------------------------- AqueK102_Aque HLVLWSMAVPVDRLVPPSLLNVIHLPAG----------------------ISSVTTVEWT CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe ----------------------------------------------------------Q- CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe ------------------------------------------------------------ CRK7_d_Smoe ------------------------------------------------------------ CG7597_Dmel RA---------------------------------------------------------- CRK7_Mmus ------------------------------------------------------------ CHED_Mmus ------------------------------------------------------------ B0285.1_Cele ------------------------------------------------------------ CTK1_Scer ---SG------------------------YQSNMDN------------------------ CRK7_Hsap ------------------------------------------------------------ CHED_Hsap ------------------------------------------------------------ DDB0229428_Ddis ------------------------------------------------------------ DDB0229428_C2d_Ddis ------------------------------------------------------------ 11773_Tthe ------------------------------------------------------------ CRK7_Spur ------------------------------------------------------------ CC1G_14638_Ccin ------------------------SPSPYERPRAVH------------------------ AqueK102_Aque IINKNYLLSVGSASGHVLLLEWVESAFPYEEPMVYHIWSCNDEVPVGHMTWSCSEDVKWL CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe ------------------------------------------------------------ CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe ------------------------------------------------------------ CRK7_d_Smoe ------------------------------------------------------------ CG7597_Dmel ---------------------------------KSYSSIDSMSDNDINA-LLDRRYTPPT CRK7_Mmus ------------------------------------------------------------ CHED_Mmus ------------------------------------------------------------ B0285.1_Cele ------------------------------------------------------------ CTK1_Scer --------------------------I---------------SSHR-------------- CRK7_Hsap ------------------------------------------------------------ CHED_Hsap ------------------------------------------------------------ DDB0229428_Ddis ------------------------------------------------------------ DDB0229428_C2d_Ddis ------------------------------------------------------------ 11773_Tthe ------------------------------------------------------------ CRK7_Spur ------------------------------------------------------------ CC1G_14638_Ccin ------------------------------------------------------------ AqueK102_Aque IYSKGCYTFAVLIKYMNNELMTSDPYLLSSNHTHPVSGITSLHNNDVITCSTDGT----- CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe ------------------------------------------------------------ CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe ------------------------------------------------------------ CRK7_d_Smoe ------------------------------------------------------------ CG7597_Dmel APSKSNERTVSAAPSSFT------------PHN--------------------------- CRK7_Mmus -----------GLVTP-------------------------------------------- CHED_Mmus -GQEAEKRRVFSLPQPQQ------------DGG--------------------------- B0285.1_Cele -ISPQYKQRNWSRG---------------------------------------------- CTK1_Scer ---------VNSND---------------------------------------------- CRK7_Hsap -----------GLVTP-------------------------------------------- CHED_Hsap -GQEAEKRRVFSLPQPQQ------------DGG--------------------------- DDB0229428_Ddis ------------------------------------------------------------ DDB0229428_C2d_Ddis ------------------------------------------------------------ 11773_Tthe ------------------------------------------------------------ CRK7_Spur ------------------------------------------------------------ CC1G_14638_Ccin ------------------------------------------------------------ AqueK102_Aque ---------ITSRPLPNMEGVTVGASASDTVINGKEEWSPVSLGGKITAGSCFGMDSSKN CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe ---ESPKAKSYSRPQLRH------------FNGS-------------------------- CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe ------------------------------------------------------------ CRK7_d_Smoe ------------------------------------------------------------ CG7597_Dmel -----------LKESSSPATPPPVRRPNTNSNYY-----GESSLETANSALGSNLQVTVT CRK7_Mmus -----------EAASLGTIIKPLVEYDDISSDSDTF------------------------ CHED_Mmus -----------GGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGG---- B0285.1_Cele ------------------------------------------------------GG---- CTK1_Scer ------------------------------------------------------------ CRK7_Hsap -----------EAASLGTVIKPLVEYDDISSDSDTF------------------------ CHED_Hsap -----------GGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGG---- DDB0229428_Ddis ---------------------EIIEKPNINNNN-----NNNNSNN------------SNN DDB0229428_C2d_Ddis ---------------------EIIEKPNINNNN-----NNNNSNN------------SNN 11773_Tthe ------------------------------------------------------------ CRK7_Spur -----------------QVVKPLVEYDDVSSEDY-------------------------- CC1G_14638_Ccin ------------------------------------------------------------ AqueK102_Aque DLYTIIHVKTVDKVSTQLLILPLILPEDVSLIWQR------SSSWDLYESLRSNLS---- CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe -----------ARIETLEGLNGIVE----------------------------------- CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe ------------------------------------------------------------ CRK7_d_Smoe ------------------------------------------------------------ CG7597_Dmel NKQSISNRLRSPPPSSRSSGNGPRFGNS---PRTPPPSHYSSSG--G-GGVG-------- CRK7_Mmus -----------------S---DDTAFKS---DRRENEERRGTDRSDRLHRHR-------- CHED_Mmus ----------NGGSPASSSGTQRRAEGS---ERRPRRDRRS---SSGRSKER-------- B0285.1_Cele ----------GGGRDRGRNDFSYRKKGK---DYNKRRDKR------SRSRSR-------- CTK1_Scer ------------------------------------------------------------ CRK7_Hsap -----------------S---DDMAFKL---DRRENDERRGSDRSDRLHKHR-------- CHED_Hsap ----------SGGSPASSSGTQRRGEGS---ERRPRRDRRS---SSGRSKER-------- DDB0229428_Ddis NNNN-------------------------------------------------------- DDB0229428_C2d_Ddis NNNN-------------------------------------------------------- 11773_Tthe ------------------------------------------------------------ CRK7_Spur ---------SLSPPPS----------------PTPPPKRRASPQ--PQKKRR-------- CC1G_14638_Ccin ---------------------------------------RL---PTANSSALH------- AqueK102_Aque ---------------------LIYEEGETRIESLPLAMRRH---AAALSHDQELMFQIDG CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe ------------------------------------KDRE-------RSKAR-------- CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe ------------------------------------------------------------ CRK7_d_Smoe ------------------------------------------------------------ CG7597_Dmel --SG--------------------------SV----VRDSRS-SRYVNSPHKEDVSAHHR CRK7_Mmus --HHQHRRSR---------------DLLKTKQ----TEKEKNQEV-SKSGSMKDRVS--- CHED_Mmus --HREHRRRD---------------GTRSGSE----ASKARSR--HGHSGEERAEAAKS- B0285.1_Cele --HRSPKR---------------------------------------------------- CTK1_Scer ---------------------------------------------------------QPG CRK7_Hsap --HHQHRRSR---------------DLLKAKQ----TEKEKSQEVSSKSGSMKDRIS--- CHED_Hsap --HREHRRRD---------------GQRGGSE----ASKSRSR--HSHSGEERAEVAKS- DDB0229428_Ddis -----------------------------------------------------------N DDB0229428_C2d_Ddis -----------------------------------------------------------N 11773_Tthe ------------------------------------------------------------ CRK7_Spur --HV--------------------------SP----ATAIKI--YKTQQGKESPHVSNSK CC1G_14638_Ccin ------------------TAPATG--------KSKKAGKQ-----------------RNG AqueK102_Aque ELLSQHCRRYLSEFMKWTEDNEIQNGDKSIKMSSEATGRPHNDE-LVSPGELSPE--DAP CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe --TRQNGR---------------------------------------------------- CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe ------------------------------------------------------------ CRK7_d_Smoe ------------------------------------------------------------ CG7597_Dmel --SSHDHGYQGRYSGAGSSSHDTRKVKRLSPELDRYNHQPSTPPHKRRKFSDGREVGLGN CRK7_Mmus GSSKRSVEGSDDYGKAQLSKSGSKESRSSKMHKEKTRK-ERELKSGYKDRS--------K CHED_Mmus GSSSS-SGGRRKSASATSSSSSSRKDRDLKAHRSRTKS-SKEPPSAYKEPP--------K B0285.1_Cele ------------------------------------------------------------ CTK1_Scer HT------KS----RG-------------------------------------------- CRK7_Hsap GSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRK-ERELKSGHKDRS--------K CHED_Hsap GSSSS-SGGRRKSASATSSSSSSRKDRDSKAHRSRTKS-SKEPPSAYKEPP--------K DDB0229428_Ddis NN------NSRESTT--------------------------------------------- DDB0229428_C2d_Ddis NN------NSRESTT--------------------------------------------- 11773_Tthe ------------------------------------------------------------ CRK7_Spur NSSSRRQPSPETYSVSQKSHSSSRKGRASEASRPRAYQSSPPPPTRYHT----------- CC1G_14638_Ccin HK------NA----RGSTGKQPARYPEDDVAADSLSMP-PPPPPS--------------- AqueK102_Aque KKKKRS--KTRK--SSTHHHTSTSGGKTSKQKRRKTSG-EGEVGGVYKSPS--------D CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe ------------------------------------------------------------ CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe ------------------------------------------------------------ CRK7_d_Smoe ------------------------------------------------------------ CG7597_Dmel FEHSRHHSGKYERYSRDRY------------------SRR-------------------- CRK7_Mmus SHRKRET-P-------KSYKT-------VASPKRRSRSPHRKWSDSSKQDDSPSGASYGQ CHED_Mmus AYREDKSEP-------KAYRR-----------RQRSLSPL------GGRDESP------- B0285.1_Cele ------------------------------------------------------------ CTK1_Scer -------------------------N------------------------------NNLS CRK7_Hsap SHRKRET-P-------KSYKT-------VDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQ CHED_Hsap AYREDKTEP-------KAYRR------------RRSLSPL------GGRDDSP------- DDB0229428_Ddis ------------------------------------------------------------ DDB0229428_C2d_Ddis ------------------------------------------------------------ 11773_Tthe ------------------------------------------------------------ CRK7_Spur -------------------------------------SPPR------------------- CC1G_14638_Ccin -------------------------------------------------------RPKQS AqueK102_Aque KHKKDSK-R-------RKKRRISGGGHYIETGRRRLSSSDNDHAYPMYDMISPPGSPYGR CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe ------------------------------------------------------------ CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe ------------------------------------------------------------ CRK7_d_Smoe ------------------------------------------------------------ CG7597_Dmel --SSRSPSVQHSRSRQSPS----GGLSSGSNAFRHGGSHKHKYGTTVS------------ CRK7_Mmus D-Y--DLSPPRSHTSSNYD----SYKKS-------------PGSTSRRQSISPPYKEPSA CHED_Mmus ----------VSHRASQSL----RSRKS-------------PS---------P------- B0285.1_Cele -----------SGSS--------------------------------------------- CTK1_Scer RYN--DT----------------------------------------------------- CRK7_Hsap D-Y--DLSPSRSHTSSNYD----SYKKS-------------PGSTSRRQSVSPPYKEPSA CHED_Hsap ----------VSHRASQSL----RSRKS-------------PS---------P------- DDB0229428_Ddis -------NNNSS----------------GNNII--------------------------- DDB0229428_C2d_Ddis -------NNNSS----------------GNNII--------------------------- 11773_Tthe ------------------------------------------------------------ CRK7_Spur --Y--SASPKRSKQSKSKQ----KYRKS-------------PTSSRKNRSPSPDYYQTSR CC1G_14638_Ccin RQQ--TPDWRDEHTP---LLNPNPNGLP-------------PKPIS--LPEKPTRIVP-- AqueK102_Aque RHH--SPSPRRGHTP---IY---KRGRS-------------PYSPR--NSHTPSHYSP-- CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe ------------------------------------------------------------ CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe ------------------------------------------------------------ CRK7_d_Smoe ------------------------------------------------------------ CG7597_Dmel -------------------------STPSHTTRTSKRASGTGTS----GDR------YSR CRK7_Mmus YQSSTRSPSPYSRR-QRSVSPYSRRRSSSYERSG----SYSG---------------RSP CHED_Mmus ---AGGGSSPYSRRLPRSPSPYSRRRSPSYSRHS----SYER------GGD------VSP B0285.1_Cele ------------------------------------------------------------ CTK1_Scer ---------SF--------QTSSRYQGSRYNNNN----TS---------------YENRP CRK7_Hsap YQSSTRSPSPYSRR-QRSVSPYSRRRSSSYERSG----SYSG---------------RSP CHED_Hsap ---AGGGSSPYSRRLPRSPSPYSRRRSPSYSRHS----SYER------GGD------VSP DDB0229428_Ddis ------------------------------------------------------------ DDB0229428_C2d_Ddis ------------------------------------------------------------ 11773_Tthe ------------------------------------------------------------ CRK7_Spur QS------------------NKSRSRSPSYSKSK----TKSRKR----HQR------ISR CC1G_14638_Ccin ---QRN------------------------------------------------------ AqueK102_Aque ---GRR---GY--------SPRSRDYSPRYSPRR----SHTPRRGYSPRGHYSPRRGHSP CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe ------------------------------------------------------------ CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe ------------------------------------------------------------ CRK7_d_Smoe ------------------------------------------------------------ CG7597_Dmel SPR-TSSRYMES-SPPSPVGASGSHHYHH-RRSPRMRQRTRGDSRRRSPSSASSESSASR CRK7_Mmus SPY-G---RRRSSSPF--------LSKRSLSRSPLPS-RKSMKSRSRSPAYSRHSSSHSK CHED_Mmus SPY-SSSSWRRSRSPY----------------SPV-L-RRSAKSRSRSPYSSRHSRSRSR B0285.1_Cele ------------------------------------------------------------ CTK1_Scer KSIK----RDETKAEF--------LS--HLPKGPKS------------------------ CRK7_Hsap SPY-G---RRRSSSPF--------LSKRSLSRSPLPS-RKSMKSRSRSPAYSRHSSSHSK CHED_Hsap SPY-SSSSWRRSRSPY----------------SPV-L-RRSGKSRSRSPYSSRHSRSRSR DDB0229428_Ddis ------------------------------------------------------------ DDB0229428_C2d_Ddis ------------------------------------------------------------ 11773_Tthe ------------------------------------------------------------ CRK7_Spur SPS--GSPY-----------------------------RRSKHSPSRSPSPYR---GKKR CC1G_14638_Ccin ------------------------------------------------------------ AqueK102_Aque SPRRGHTPSRRGYSPV--------HK-RRYSPVRRGH-TPSFKRRGSPKATHRRSSPHYF CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe -----------------------------------------------------EDSMD-- CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe ------------------------------------------------------------ CRK7_d_Smoe ------------------------------------------------------------ CG7597_Dmel SRSPTSRDLKHK--REEYIKKISET-----------------------SLFAELVKDRHK CRK7_Mmus KKRSGSRS-RHS--SISPVRLPLNS-----------------------SLGAELSRKKKE CHED_Mmus HRLSRSRS-RHS--SISPSTLTLKS-----------------------SLAAELNKNKKA B0285.1_Cele ---KKSKR-RNS--SGSSSSDLMDT-----------------------SLMSELKKHGDY CTK1_Scer --VEKS---R--------------------YNNSSNTSNDIKNGYH-------------- CRK7_Hsap KKRSSSRS-RHS--SISPVRLPLNS-----------------------SLGAELSRKKKE CHED_Hsap HRLSRSRS-RHS--SISPSTLTLKS-----------------------SLAAELNKNKKA DDB0229428_Ddis --------------------NNNNNNINNNINNNNNINNNINNNSN-------------- DDB0229428_C2d_Ddis --------------------NNNNNNINNNINNNNNINNNINNNSN-------------- 11773_Tthe ------------------------------------------------------------ CRK7_Spur ARSPT----------PNFPATKFHS-----------------------SIGGEVQKYRKK CC1G_14638_Ccin ----------------------------------AGF----KPIGQSNSAL--------- AqueK102_Aque TRRSRSPR-RRSYTPRSPSPPPFSPARRVVHRSRSPLTTPPLHRQHRSPVYRHVKKVNSK CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe ----KRRA-R-------------------------------------------------- CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe ------------------------------------------------------------ CRK7_d_Smoe ------------------------------------------------------------ CG7597_Dmel RQKA-LK-EIIERQEENSNSN--SNGALTINDNSSSVDGNTP------------NAADGR CRK7_Mmus RAAAAAAAK-------------MDGKESKSSPIILPKKEKL--EVKESGLESKKLPRSI- CHED_Mmus RAAEAARAAEAAKAAEAAKAAEAAAKAAKASNASTPTKGNTETGASVSQTNHVKEVKKL- B0285.1_Cele GSSSK--------------SKKKSRKRRKHSSSSSSSSG---------E--AMDLPVSSN CTK1_Scer ------------------------------------------------------------ CRK7_Hsap RAAAAAAAK-------------MDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRSV- CHED_Hsap RAAEAARAAEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKI- DDB0229428_Ddis ---------------------------------SSSNNN-----------NNNNLPQ--- DDB0229428_C2d_Ddis ---------------------------------SSSNNN-----------NNNNLPQ--- 11773_Tthe ------------------------------------------------------------ CRK7_Spur TVQA-AKAKVVKQEKEPSPEP--VP-----------------------------EPVKVK CC1G_14638_Ccin KMF--------------------------------------------------------- AqueK102_Aque RSS--------------------------------------------------------- CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe ---------LHAQ--DPN------------------------------------------ CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe ------------------------------------------------------------ CRK7_d_Smoe ------------------------------------------------------------ CG7597_Dmel --SAPGSGTPAAASTTSNGLQALGSKPD-LDL--NNIP----MPNKQND-SVV-----SN CRK7_Mmus --KSEKSTPDTELVTVAHSN--PEVKHC-LDTGKVRLDENLQKHPAKDLKAQGTKD--VK CHED_Mmus --KTEHAPSPSSGGTVKSDK--AKTKPP-LQVTKV--DNNLTVEKATKKT-VVGKE--SK B0285.1_Cele GMNVTAIPPPPSFNINPFQP--MFSQPP-PP----------------------------- CTK1_Scer ------------------------------------------------------ASKYY- CRK7_Hsap --KLEKSAPDTELVNVTHLN--TEVKNS-SDTGKVKLDENSEKHLVKDLKAQGTRD--SK CHED_Hsap --KIEHAPSPSSGGTLKNDK--AKTKPP-LQVTKV--ENNLIVDKATKKAVIVGKE--SK DDB0229428_Ddis --------------------------------------------------------NG-- DDB0229428_C2d_Ddis --------------------------------------------------------NG-- 11773_Tthe ------------------------------------------------------------ CRK7_Spur QVKQPKPESPM-VFTIKNDLK--ETASPQRTV--VELP--------DRG-LIIKKE--LK CC1G_14638_Ccin -----------------------------FPGDEDEADYISSSNLTKDARTEPTPTKGFT AqueK102_Aque -----------------------------IDHGEVHED-----LPSKELSPNGD------ CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe ------------------------------------------------------------ CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe ------------------------------------------------------------ CRK7_d_Smoe ------------------------------------------------------------ CG7597_Dmel PASNADVPDSVAQ------LKQ--PL---------------------------------- CRK7_Mmus PVAPKEVIVTSKETETSEKETL--PPLPTITSPP----PLPATTPPPQTPPLPP------ CHED_Mmus PAATKEEPVSTKE------KSK--PLTPSTGAK--------------------------- B0285.1_Cele ------------------------PLPP-------------------------------- CTK1_Scer ------------------------------------------------------------ CRK7_Hsap PIALKEEIVTPKETETSEKETP--PPLPTIASPP-P--PLPTTTPPPQTPPLPP------ CHED_Hsap SAATKEESVSLKE------KTK--PLTPSIGAK--------------------------- DDB0229428_Ddis -------------STHKEESTT--SSSSTINSNP-N--PNPNPNPN-------------- DDB0229428_C2d_Ddis -------------STHKEESTT--SSSSTINSNP-N--PNPNPNPN-------------- 11773_Tthe ------------------------------------------------------------ CRK7_Spur PVVPSPVPAPA------------------------------------------------- CC1G_14638_Ccin RQTLLDDTRNGREAENPHQYGNDPP---PISRPPASWDP---YASTYPVDPRVPTQSYTN AqueK102_Aque -------ALVEKCTSKSGPKT---P---PMTTPS-ETTP---SSPSKPPPPVDE------ CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe --------------------------------------PRQSVIPK-------------- CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe ------------------------------------------------------------ CRK7_d_Smoe ------------------------------------------------------------ CG7597_Dmel -------------------------------------------------LVPPF------ CRK7_Mmus --LPPLPAIPLQPPLPPPQPPFSQVPVSSTSILPSSPHPRTSTLSSQTNSQPPVQVSMKT CHED_Mmus -----EKEQ--------------------------------------------------- B0285.1_Cele -----NSQF--------------------------------------------------- CTK1_Scer ----------------NHKGQEGR------------------------------------ CRK7_Hsap --LPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQANSQPPVQVSVKT CHED_Hsap -----EKEQ--------------------------------------------------- DDB0229428_Ddis -------------PNPNPN---------------------------PINKAPTIHGTVIT DDB0229428_C2d_Ddis -------------PNPNPN---------------------------PINKAPTIHGTVIT 11773_Tthe ------------------------------------------------------------ CRK7_Spur ----------------------------------------------------PV------ CC1G_14638_Ccin GLTPHL---PEPPPHIPHRTGQTQSYWKSPAVSPP---PESDASRWSGVPVPPV------ AqueK102_Aque --LPPL---PAEA-------------------PPP---P-------------P------- CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe ----------------------------------------------QA------EGEQV- CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe ------------------------------------------------------------ CRK7_d_Smoe ------------------------------------------------------------ CG7597_Dmel ----SASKNNIKPKSLTSL-----PL--------PPGMNV---LDLAGARSPSPGQKKES CRK7_Mmus QVSITAAIPHLKTSTLPPL-----PL--------PPLLPGDDDMDSPKETLPSKPAKKEK CHED_Mmus -------HVALVTSTLPPL-----PL--------PPMLPEDKDADSLRGNISVKAVKKEV B0285.1_Cele -------MT--------PP-----PR--------PPPAPFSIPPPSVDIHFAA------- CTK1_Scer ------------------------------------------------------------ CRK7_Hsap QVSVTAAIPHLKTSTLPPL-----PL--------PPLLPGDDDMDSPKETLPSKPVKKEK CHED_Hsap -------HVALVTSTLPPL-----PL--------PPMLPEDKEADSLRGNISVKAVKKEV DDB0229428_Ddis TAML------------------------------TGIINSVSNM---------------- DDB0229428_C2d_Ddis TAML------------------------------TGIINSVSNM---------------- 11773_Tthe ------------------------------------------------------------ CRK7_Spur ----RTTPPPKQTSARPPL-----PL--------PPMIDA---VDSPVIAQKGKGDVAER CC1G_14638_Ccin ----HPNLPPTYTASVPPRPGYELPYRPPVPVDNAPVSHTTK------------------ AqueK102_Aque -----PE---EEKPPLPPI-----PL--------PPTLIGQSE----------------- CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe ------------------------------------------------------------ CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe ------------------------------------------------------------ CRK7_d_Smoe ------------------------------------------------------------ CG7597_Dmel DEKNVT-SSGSANKSVLNLPMPP-VIPGSEELSGDDDVIDSPEDFD-APAVGT-VHGHGG CRK7_Mmus E--------QRTRHLLTDLPLPP-ELPGGDPSP-----PDSPEPKA-IT----------- CHED_Mmus E--------KKLRCLLADLPLPP-ELPGGDDL------SKSPEEKK-TA----------- B0285.1_Cele ----------TASFSLSSIPPPPPQTDGGASS------SKRQDPLP-MP----------- CTK1_Scer -------------------------------------S---VIAKKV--PV--------- CRK7_Hsap E--------QRTRHLLTDLPLPP-ELPGGDLSP-----PDSPEPKA-IT----------- CHED_Hsap E--------KKLRCLLADLPLPP-ELPGGDDL------SKSPEEKK-TA----------- DDB0229428_Ddis ------------------------------------------------------------ DDB0229428_C2d_Ddis ------------------------------------------------------------ 11773_Tthe ------------------------------------------------------------ CRK7_Spur -MRNLSRDRARSRTSITDLPLPP-MAPTPDESP-----VDTPSPQT-QLHLRAKEKD-TK CC1G_14638_Ccin -----------------STPQPS-PIPISDPSPAWQAS---ASASGVATPV--------- AqueK102_Aque ----------------PKLPPPP-LINDLSHRPVK--------SK--AIPT--------- CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe ------------------------------------------------------------ CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe ------------------------------------------------------------ CRK7_d_Smoe ------------------------------------------------------------ CG7597_Dmel -GPGTTRQRPVILNRR---DSRNNV-RDWGERC-VDVFEMIAQIGEGTYGQVYKARDHHT CRK7_Mmus PPQQPYKKRPKICCPR-YGERRQTE-SDWGKRC-VDKFDIIGIIGEGTYGQVYKAKDKDT CHED_Mmus -AQLHSKRRPKICGPR-YGEIKEKD-IDWGKRC-VDKFDIIGIIGEGTYGQVYKARDKDT B0285.1_Cele PDSKRIATRPVITTRRGHATNRPSDSDSWYKTN-LTHYTMLDQIGEGTYGQVYKAVNNLT CTK1_Scer -------------------------SVLTQQRS-TSVYLRIMQVGEGTYGKVYKAKNTNT CRK7_Hsap PPQQPYKKRPKICCPR-YGERRQTE-SDWGKRC-VDKFDIIGIIGEGTYGQVYKAKDKDT CHED_Hsap -TQLHSKRRPKICGPR-YGETKEKD-IDWGKRC-VDKFDIIGIIGEGTYGQVYKARDKDT DDB0229428_Ddis ---------------D-NIRYNNSD-SVWGSRS-VDSHEKIEQIGEGTFGQVYKAKNKSN DDB0229428_C2d_Ddis ---------------D-NIRYNNSD-SVWGSRS-VDSHEKIEQIGEGTFGQVYKAKNKSN 11773_Tthe ----------------------------IRTRNIRKYYRLIAEVGSGTYGRVYKAECLRT CRK7_Spur DPKVDLGKREMIRQRR--AKMAGSS-LDWGERC-VDVFEIINQIGEGTYGQVYKARDKDT CC1G_14638_Ccin AP--------------------------EQPES-KDLYVILNQVGEGTFGKVYKARNTVA AqueK102_Aque PP-------------------ELA-ALQLSHRC-VSSFEILSQIGEGTFGKVYKAKDLKT CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe -----AAGWPGWLSAV----AGEAI-KGWIPRR-ADSFEKLDKIGQGTYSNVYKARDLDS CRK7_e_Smoe -----------------------------EFPA-LERYVAVESIGRGKYGKVFLATDKQT CRK7_b_Smoe ------------------------------------------------------------ CRK7_d_Smoe -----------------------------EFPA-LERYVAVESIGRGKYGKVFLATDKQT CG7597_Dmel NDMVALKKV--RLEHE------------KEGFPITAVREIKILRQLNHRNIVNLHEIVTD CRK7_Mmus GELVALKKV--RLDNE------------KEGFPITAIREIKILRQLVHQSVVNMKEIVTD CHED_Mmus GEMVALKKV--RLDNE------------KEGFPITAIREIKILRQLTHQSIINMKEIVTD B0285.1_Cele GEQVALKRV--RLENE------------KEGFPITAIREIKILRQLHHKNIVRLMDIVID CTK1_Scer EKLVALKKL--RLQGE------------REGFPITSIREIKLLQSFDHPNVSTIKEIMVE CRK7_Hsap GELVALKKV--RLDNE------------KEGFPITAIREIKILRQLIHRSVVNMKEIVTD CHED_Hsap GEMVALKKV--RLDNE------------KEGFPITAIREIKILRQLTHQSIINMKEIVTD DDB0229428_Ddis GDIVALKKV--IMDNE------------VEGFPITAIREIKILKELNHANVVNLKEVVTS DDB0229428_C2d_Ddis GDIVALKKV--IMDNE------------VEGFPITAIREIKILKELNHANVVNLKEVVTS 11773_Tthe KQYVALKKF--ESKDDK---------IKEDGFPITAVREILLLKQLDHVNIIKLREIILS CRK7_Spur GELVALKKV--RTDNE------------KEGFPITAVREIKILRQLNHDSVIRLHEIVTD CC1G_14638_Ccin KVHVALKRI--RMETE------------RDGFPVTAMREIKLLQSLKHPNVVQLYEMMVS AqueK102_Aque GEVIALKKVLIRTDSE------------REGFPITAVREIKILRQLRHENIVTLKEIISD CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe GKVVALKKV--RFDSL------------EPESVKFMAREIQILRRLDHPNVVKLEGLVTS CRK7_e_Smoe SERVAIKRL--RVDPKEATLKVREAGGELRDVPASIAIEIKVLRLLNNDHVVKLLDVIYA CRK7_b_Smoe -----------------------------------MAREIQVLRRLNHPNVIKLEGLVTS CRK7_d_Smoe SERVAIKRL--RVDPKEATLKVREAGGELRDVPASIAIEIKVLRLLNNDHVVKLLDVIYA CG7597_Dmel KQDAVEFRKDK-GSFYLVFEYMDHDLMGLLESG-MVDFNEENNASIMKQLLDGLNYCHKK CRK7_Mmus KQDALDFKKDK-GAFYLVFEYMDHDLMGLLESG-LVHFSEDHIKSFMKQLMEGLDYCHKK CHED_Mmus KEDALDFKKDK-GAFYLVFEYMDHDLMGLLESG-LVHFNENHIKSFMRQLMEGLDYCHKK B0285.1_Cele DISMDELKRTR-ANFYLVFEYVDHDLIGLLESKELVDFNKDQICSLFKQLLEGLAYIHNT CTK1_Scer SQ----------KTVYMIFEYADNDLSGLLLNK-EVQISHSQCKHLFKQLLLGMEYLHDN CRK7_Hsap KQDALDFKKDK-GAFYLVFEYMDHDLMGLLESG-LVHFSEDHIKSFMKQLMEGLEYCHKK CHED_Hsap KEDALDFKKDK-GAFYLVFEYMDHDLMGLLESG-LVHFNENHIKSFMRQLMEGLDYCHKK DDB0229428_Ddis KASASN--NHK-GSVYMVFEYMDHDLNGLMDSPAFKYFAPGQIKCYLKQLLEGLDYCHRN DDB0229428_C2d_Ddis KASASN--NHK-GSVYMVFEYMDHDLNGLMDSPAFKYFAPGQIKCYLKQLLEGLDYCHRN 11773_Tthe KPSEKN--DYR-GSTFLVFDYMDHDFAGLHRN-KH-EFSLQELKCIMKQILLGVQYLHYK CRK7_Spur KQDALDFKKDK-GAFYLVFEYMDHDLMGLLESG-LVNFSEEHVRSFMKQLLDGLNYCHKR CC1G_14638_Ccin N-----------GSVFMVFEYMDHDLTGILSQT-QFKFSDSHLKSLCHQMLAGLAYLHHK AqueK102_Aque TPQAASLKHDKSSSFYLVFEYCAHDLMGLIDSG-MVVFSESHIQSLMRQLMEALCYCHSK CRK7_c_Smoe ---------------------------------------------------------HTR CRK7a_Smoe RMS---------SSLYLVFEYMEHDLAGLAACP-GIMFTEPQVKCYLQQLIRGLDHCHTR CRK7_e_Smoe AT-----------DIFLVFEYMKHDLCGLIHRH---KFSAPEIKCYLKQILEGLHYCHLN CRK7_b_Smoe RMS---------FSLYLVFEYMEHDLAGLAACP-GITFTEPQVKCYMQQLIRGLDHCHTR CRK7_d_Smoe AT-----------DIFLVFEYMKHDLCGLIHRH---KFSAPEIKCYLKQILEGLHYCHLN * CG7597_Dmel NFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPYTNKVITLWYRPPELLLGEER CRK7_Mmus NFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEE-SRPYTNKVITLWYRPPELLLGEER CHED_Mmus NFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEE-SRPYTNKVITLWYRPPELLLGEER B0285.1_Cele GFLHRDIKCSNILVNNKGELKIADLGLARLWEK-E-SRLYTNRVITLWYRPPELLLGDER CTK1_Scer KILHRDVKGSNILIDNQGNLKITDFGLARKMNSR---ADYTNRVITLWYRPPELLLGTTN CRK7_Hsap NFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEE-SRPYTNKVITLWYRPPELLLGEER CHED_Hsap NFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEE-SRPYTNKVITLWYRPPELLLGEER DDB0229428_Ddis NVLHRDIKGSNLLLDNNGILKLADFGLARPFNSSEKKQILTNRVITLWYRPPELLLGTFH DDB0229428_C2d_Ddis NVLHRDIKGSNLLLDNNGILKLADFGLARPFNSSEKKQILTNRVITLWYRPPELLLGTFH 11773_Tthe KVIHRDLKIANILYNNQGEVKIADFGLARLLNP-NN-PKYTNKVVTLWYRAPELLLGAKE CRK7_Spur NFLHRDIKCSNILLNNKGHIKLADFGLARLYHADDKTRPYTNKVITLWYRPPELLLGEER CC1G_14638_Ccin GVIHRDIKGSNILLNNRGELKLADFGLARFYQKR-RRTDYTNRVITLWYRPPELLFGATV AqueK102_Aque NFLHRDLKCSNILINNKGQLKLGDWGLARYYFADDHSRLYTNHVITLWYRPPELLLGAEH CRK7_c_Smoe GVLHRDIKGSNLLIDNSGILKIADFGLATFYHPYQ-NLALTSRVVTLWYRPPELLLGATE CRK7a_Smoe GVLHRDIKGSNLLIDNSGILKIADFGLATFYHPYQ-NLALTSRVVTLWYRPPELLLGATE CRK7_e_Smoe GVMHRDIKSSS------------------------------------------------- CRK7_b_Smoe GVLHRDIKGSNLLLDNSGILKIADFGLATFFHPDQ-RQALTSRVVTLWYRPPELLLGATE CRK7_d_Smoe GVMHRDIKSANLLVSGKGVLKLADFGMSTPI-PET-PRPLHCGVVTLWNRPPELLLGFSS .:***:* :. CG7597_Dmel YG--------------------------------------PSIDVWSCGCILGELFVKRP CRK7_Mmus YT--------------------------------------PAIDVWSCGCILGELFTKKP CHED_Mmus YT--------------------------------------PAIDVWSCGCILGELFTKKP B0285.1_Cele YG--------------------------------------PAIDVWSTGCMLGELFTRKP CTK1_Scer YG--------------------------------------TEVDMWGCGCLLVELFNKTA CRK7_Hsap YT--------------------------------------PAIDVWSCGCILGELFTKKP CHED_Hsap YT--------------------------------------PAIDVWSCGCILGELFTKKP DDB0229428_Ddis YG--------------------------------------PEIDMWSVGCIMAELLSKKT DDB0229428_C2d_Ddis YG--------------------------------------PEIDMWSVGCIMAELLSKKT 11773_Tthe YTEQHILKELIRNIKSIQLSLLISIYLKLTVQSSIFKKSNKQIDMWSVGCIFIELAVGEN CRK7_Spur YG--------------------------------------PAVDVWSCGCILGELFTQRP CC1G_14638_Ccin YG--------------------------------------PEVDMWSAGCIMLELFTKKP AqueK102_Aque YG--------------------------------------PAVDIWSCGCILGELFTKKP CRK7_c_Smoe YS--------------------------------------VGVDLWSTGCILAELLAGKP CRK7a_Smoe YS--------------------------------------VGVDLWSTGCILAELLAGKP CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe YG--------------------------------------AAVDLWSTGCILAELLAGKP CRK7_d_Smoe YG--------------------------------------PAVDMWSLGCVFAELLVCQS CG7597_Dmel LFQANAEMAQLETISKICGSPVPAVWPNVIKLPLFHTLKQKKT--HRRRLREDF------ CRK7_Mmus IFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQ--YRRRLREEF------ CHED_Mmus IFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQ--YRRKLREEF------ B0285.1_Cele LFNGNNEFGQLELISKVCGSPNVDNWPELTELVGWNTFRMKRT--YQRRIREEF------ CTK1_Scer IFQGSNELEQIESIFKIMGTPTINSWPTLYDMPWFFMIMPQQTTKYVNNFSEKF------ CRK7_Hsap IFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQ--YRRRLREEF------ CHED_Hsap IFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQ--YRRKLREEF------ DDB0229428_Ddis LFPGRNSIDQLDKIYQVCGSPNANNWPEAMDLPFWDALKPKRE--YNSLSLKDFYQHENP DDB0229428_C2d_Ddis LFPGRNSIDQLDKIYQVCGSPNANNWPEAMDLPFWDALKPKRE--YNSLSLKDFYQHENP 11773_Tthe LLRGENEPRQLDKIYELCGSPNTQNWPEVDKLQLWKDMKPKRN--FERKLREQVI--ERK CRK7_Spur IFQANQELAQLELISRICGTPTPAVWPDVIRLPLFNTMKPKKM--YNRRLREEF------ CC1G_14638_Ccin VFQGNDEINQLHVIFKILGTPTTERWTGLNNLPWFELIKPKES--LPNRFRDLF------ AqueK102_Aque LFHGSIEMEQLDAISI-------------------------------------------- CRK7_c_Smoe IMPGRTEVCSLVFVLRCLVTPA-------------------------------------- CRK7a_Smoe IMPGRTEVEQLHKIFKLCGSPSEEYWKK-SKLPHATIFKPQQP--YKRCIADTY------ CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe IMPGRTEVEQLHKIFKLCGSPAEEYWKK-WKLPHAIIFKPQQP--YKRCIAETF------ CRK7_d_Smoe ILPGKDEKQQLSWIFKMCGTPDETSWPGVSKSPVYAKFVAENGK-KPRRLRKAF------ CG7597_Dmel EF-MPA-PALDLLDKMLDLDPDKRITAEDALRSPWLRKINPDEMPTPQLPTW-QDCHELW CRK7_Mmus SF-IPS-AALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHW-QDCHELW CHED_Mmus VF-IPA-AALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLW-QDCHELW B0285.1_Cele EHIMPR-EAVDLLDKMLTLNPEKRISAKEALNHPWIRSLEHTTVQPLKLPQH-QDCHEMW CTK1_Scer KSVLPSSKCLQLAINLLCYDQTKRFSATEALQSDYFKE-EPKP-EPLVLDGL-VSCHEYE CRK7_Hsap SF-IPS-AALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHW-QDCHELW CHED_Hsap VF-IPA-AALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLW-QDCHELW DDB0229428_Ddis SF-FTK-EAFDLLDKLLCMDPKKRITASEALDHQYFWT-DPMPVNPKDLPQY-PSCHEYR DDB0229428_C2d_Ddis SF-FTK-EAFDLLDKLLCMDPKKRITASEALDHQYFWT-DPMPVNPKDLPQY-PSCHEYR 11773_Tthe KN-IDP-QFLNLLDGIMVLNPKKRFTVQQCLDHEFFKV-EPLPFEISEMPKIKEECHEAL CRK7_Spur SL-LPK-DALDLLDGMLTLDPDKRTTAEDALNCGWLQTSGTGKLSQPDLPHW-QDCHELW CC1G_14638_Ccin QKWMSP-AALDLAERLLTYDPELRVSAQEAMEAPYFTQERPFAERPAGLASLDGEWHELE AqueK102_Aque ---IPE-VPLDLLDKLISIDPSKRISSEEALNHPFLINATKDSIPPPLLPSH-QDCHEMW CRK7_c_Smoe ---------FLLIDRT-------------------------------------------- CRK7a_Smoe KD-FPS-TALALLDILLAIEPADRGTAAGALKADFFNT-KPFPCDPSVLPKY-PPSKEFD CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe KD-FPA-SALALLDTLLAIEPADRQTAAAALESDFFTK-KPYACEPSSLPQY-PPSKELD CRK7_d_Smoe NN-VDP-RALDLLEQMLTLNPEKRITAEQALLSDYLWT-EPLACAPAELPISHEACTEMR CG7597_Dmel SKKRRRQMREQQESLP---------------------------------------PTV-- CRK7_Mmus SKKRRRQRQSGIVI----------EDPPPSKASRKETTSGTTAEPVKNNSPAPPQP-APV CHED_Mmus SKKRRRQKQMGMTD-----------DLSTIKAPRKDLSLGLDD--SRTNTPQGVLPPAQL B0285.1_Cele SKKQKKSARLGRQA-----------EGSS------------------------------- CTK1_Scer VKLARKQKRPNILSTNTN------------------------------------------ CRK7_Hsap SKKRRRQRQSGVVV----------EEPPPSKTSRKETTSGTSTEPVKNSSPAPPQP-APG CHED_Hsap SKKRRRQKQMGMTD-----------DVSTIKAPRKDLSLGLDD--SRTNTPQGVLPSSQL DDB0229428_Ddis TKKRLRQQNQNQNQQQN------------------------------------------- DDB0229428_C2d_Ddis TKKRLRQQNQNQNQQQN------------------------------------------- 11773_Tthe LKNVKNRNQVIQSHKNN----------FMQRA---N------------MSPSRIPP-MST CRK7_Spur SKRRRRQERQQQQQLAAQNKAGNGPDPSHSKSSRKE----------------PP-PPAPA CC1G_14638_Ccin TKQERLKKRKKT------------------------------------------------ AqueK102_Aque SKKKKKKEGKVTEGPPAE------------KPNLHN----------------PP-KGG-- CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe AKMRDEESRRQRAAKHGVA--------EGRRHGSRE------------RSRAVPAPDANA CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe AKYRDEEARRQRAGRHAGS--------DARRGSRER------------SSKAVPAPDANA CRK7_d_Smoe SKLDRKKQHQQPQQH---------QQPAKRKLERVD------------------------ CG7597_Dmel ------------------------------------------------------------ CRK7_Mmus KAEPGPGDAVGL------------------------------------------------ CHED_Mmus KSQSNSNVAPVI------------------------------------------------ B0285.1_Cele ------------------------------------------------------------ CTK1_Scer -------------------N------------------------------K-GNG----- CRK7_Hsap KVESGAGDAIGL------------------------------------------------ CHED_Hsap KSQGSSNVAPVK------------------------------------------------ DDB0229428_Ddis ------------------------------------------------------------ DDB0229428_C2d_Ddis ------------------------------------------------------------ 11773_Tthe QNQQG------------------------------------------------------- CRK7_Spur VTEEEAPQIPGLGSEEPSSS------------------------------KKGSKAASRS CC1G_14638_Ccin ------------------------------------------------------------ AqueK102_Aque -----------VASVSPSNH------------------------------Q-SSS----- CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe E--LH------------ASVQVISARNKWLHFFLFFLTFYFSIFYFLFFRQK-R------ CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe E--LP------------SSL------------------------------QK-R------ CRK7_d_Smoe ------------------------------------------------------------ CG7597_Dmel ------------------------------------------------------------ CRK7_Mmus -------------GDITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLN------------ CHED_Mmus -------------TGPGQPLNHSELAILLNLLQSKSSVNMADFVQVLN------------ B0285.1_Cele ------------------------------------------------------------ CTK1_Scer ------------------------------------------------------------ CRK7_Hsap -------------ADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLN------------ CHED_Hsap -------------TGPGQHLNHSELAILLNLLQSKTSVNMADFVQVLN------------ DDB0229428_Ddis ------------------------------------------------------------ DDB0229428_C2d_Ddis ------------------------------------------------------------ 11773_Tthe ------------------------------------------------------------ CRK7_Spur NTPQAPREGKDSSSDGGKATGEKKLAKLINLLQAQPQLNVNKLAETLN------------ CC1G_14638_Ccin ------------------------------------------------------------ AqueK102_Aque ------------------------------------------------SSSYRN------ CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe -----------------------------------------------RLSSHSSKSKSEK CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe -----------------------------------------------RIHSHSAKSKSEK CRK7_d_Smoe ------------------------------------------------------------ CG7597_Dmel ------------------------------------------------------------ CRK7_Mmus -----------IHSNPEMQQ------QLEALNQSIS---ALTEASSQQQDS--------- CHED_Mmus -----------IKVNSETQQ------QLNKINLPAG---ILAT--GEKQTD--------- B0285.1_Cele ------------------------------------------------------------ CTK1_Scer ------------------------------------------------------------ CRK7_Hsap -----------IHSNPEMQQ------QLEALNQSIS---ALTEATSQQQDS--------- CHED_Hsap -----------IKVNSETQQ------QLNKINLPAG---ILAT--GEKQTD--------- DDB0229428_Ddis ---------------QQQQQ------QQPQNQHQ-------------------------- DDB0229428_C2d_Ddis ---------------QQQQQ------QQPQNQHQ-------------------------- 11773_Tthe -----------QKSYSSSQN------QLSSNKQS-------------------------- CRK7_Spur -----------VQVDASTIK------LLENLNMQLL---IAAH--ATKQKS--------- CC1G_14638_Ccin ------------------------------------------------------------ AqueK102_Aque ------------------------------------------------------------ CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe FTYLSEKSASGFPMEPPAPRYGQQPTDVR-GTSPVPPRQFVPPASSRSGPIGNPTAATAN CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe FLPANEDPAIGFPIDPPRQS------DVK-GASPVG---RLPPASSRSGPM--------- CRK7_d_Smoe ------------------------------------------------------------ CG7597_Dmel ------------------------------------------------------------ CRK7_Mmus -ESIAPEESLKEVPSVPVVLPPAE--QTT------PEASN-TPADMQNVLAVLLSQL-MK CHED_Mmus -PSTPQQESSKSLGG---VQPS-QTIQPK------VETDA-AQAAVQSAFAVLLTQL-IK B0285.1_Cele ------------------------------------------------------------ CTK1_Scer ------------------------------------------------------------ CRK7_Hsap -ETMAPEESLKEAPSAPVILPSAE--QTT------LEASS-TPADMQNILAVLLSQL-MK CHED_Hsap -PSTPQQESSKPLGG---IQPSSQTIQPK------VETDA-AQAAVQSAFAVLLTQL-IK DDB0229428_Ddis ------------------------------------------------------------ DDB0229428_C2d_Ddis ------------------------------------------------------------ 11773_Tthe ------------------------------------------------------------ CRK7_Spur -KEGGDDA-------KPLPLPTKE--VTTDLLVKALEGSKGSGGALEQVFGPSSSEQKKH CC1G_14638_Ccin ------------------------------------------------------------ AqueK102_Aque ------------------------------------------------------------ CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe WSRKQRDEDVRMAPQRSTSRAMRS--STG------QVEVD-RITSS-------------- CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe -TRKQKEDDVRMAPPRMMTRTSKT--VTD------FNAPA-QPADLSSYSSLVAARH-GE CRK7_d_Smoe ------------------------------------------------------------ CG7597_Dmel ------------------------------------------------------------ CRK7_Mmus TQE----------------------------PAGNLEENTN----------DKNSGPQGP CHED_Mmus AQQSKQ-------------------------KDAMLEEREN----------G--SGHEAP B0285.1_Cele ---------------------------------------------------G--SGHSIR CTK1_Scer ----------------------------------N--SNNN------------------- CRK7_Hsap TQE----------------------------PAGSLEENNS----------DKNSGPQGP CHED_Hsap AQQSKQ-------------------------KDVLLEEREN----------G--SGHEAS DDB0229428_Ddis --QSQY-------------------------QGANVNHHNN----------HNNNNNQ-- DDB0229428_C2d_Ddis --QSQY-------------------------QGANVNHHNN----------HNNNNNQ-- 11773_Tthe --TSSI-------------------------QNASSSQQGNQIVGQSHFDSRNSGKSH-- CRK7_Spur AKEIATSLAQYVSALFGKPVNPSKGPTDPAPSSVVSQGKSH----------G--NAHQST CC1G_14638_Ccin ------------------------------------------------------------ AqueK102_Aque ---------------------------------ESTDHQYN----------SSCDRP--- CRK7_c_Smoe ----------------------------------------------------GG------ CRK7a_Smoe --------------------------------------SSR-----------HG------ CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe RRERRE---------------------------SRHREKEK----------EGNSGPAKP CRK7_d_Smoe ------------------------------------------------------------ CG7597_Dmel ------------------------------------------------------------ CRK7_Mmus --RRTPTMPQEEAAA-------------------------------------CPPHIL-- CHED_Mmus LQLRPPLEPSTPGSGQDDLI--QHQDRRILE----------------LTPEPDRPRIL-- B0285.1_Cele ATSHPR------------------------------------------------------ CTK1_Scer ------------------------------------------------------------ CRK7_Hsap --RRTPTMPQEEAAA-------------------------------------CPPHIL-- CHED_Hsap LQLRPPPEPSTPVSGQDDLI--QHQDMRILE----------------LTPEPDRPRIL-- DDB0229428_Ddis ---PP---PYQNGSGSNNSN--NFKKQR-------------------------------- DDB0229428_C2d_Ddis ---PP---PYQNGSGSNNSN--NFKKQR-------------------------------- 11773_Tthe ---FQ---QKQQSSSSNSSQ--QYSREHISNSKGGYYGNSNNSSSMKYT-SGG------- CRK7_Spur SIVTPPSDSRS--SYIDNLSGSQGGESSSVP----------------FSRKNSKPDFGVS CC1G_14638_Ccin ------------------------------------------------------------ AqueK102_Aque -----DGV-HQNV-----SR--QHHS-------------------------LG------- CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe ------------------------------------------------------------ CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe --SLSN--------GKAEN----------------------------------------- CRK7_d_Smoe ------------------------------------------------------------ CG7597_Dmel ------------------------IA-------------STKYQQH-------------- CRK7_Mmus ---PPEKRPPEPPGPPPPPPPPPLVEGDL-----------------SS-----AP----- CHED_Mmus ---PPDQRPPE------PPEPPPVTEEDLDYRTENQHVPTT-----SS-----SL----- B0285.1_Cele ------------------------------------------------------------ CTK1_Scer ------------------------------------------------------------ CRK7_Hsap ---PPEKRPPEPPGPPPPPPPPPLVEGDL-----------------SS-----AP----- CHED_Hsap ---PPDQRPPE------PPEPPPVTEEDLDYRTENQHVPTT-----SS-----SL----- DDB0229428_Ddis ----TD--------YNQPPPPPPSSSST------------S-----SS-----TQ----- DDB0229428_C2d_Ddis ----TD--------YNQPPPPPPSSSST------------S-----SS-----TQ----- 11773_Tthe ----AQ--------QNIPLDSGPNLKKQ------------G-----SSTVGQNQQ----- CRK7_Spur DDSQQSWKPPTPLG------PPPESPEA-----------EEQEQQQEE-----DT----- CC1G_14638_Ccin ------------------------------------------------------------ AqueK102_Aque ---PPHS-------LSVPLPPAPLSTT------------SI-----LE-----S------ CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe ------------------SFA----EQGQG--KDG------DFSK--H------------ CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe -----VEKPAEA------SKP----VEDLQ--KES------SYLK--E-----QT----- CRK7_d_Smoe --------------SLKRRPPTPSSVK------------KAKP---SS-----HGSSTIA CG7597_Dmel ------------------------------------------------------------ CRK7_Mmus --QELNPAVTAALLQLLSQ--PEAEPPGH-LPHEHQALRPMEY--S-----------TRS CHED_Mmus --TDPHAGVKAALLQLLAQHQPQDDPKRE-GGIDYPTGDT--Y--V-----------PSS B0285.1_Cele ---------------------------GK-A----------------------------- CTK1_Scer ------------------------------------------------------------ CRK7_Hsap --QELNPAVTAALLQLLSQ--PEAEPPGH-LPHEHQALRPMEY--S-----------TRP CHED_Hsap --TDPHAGVKAALLQLLAQHQPQDDPKRE-GGIDYQAGDT--Y--V-----------STS DDB0229428_Ddis --QPFNKGPYG------QP--PQVQPPGGSFVNGGNNNYPQNRNTL-------------- DDB0229428_C2d_Ddis --QPFNKGPYG------QP--PQVQPPGGSFVNGGNNNYPQNRNTL-------------- 11773_Tthe --QQYLNPPYK------KK--TSIQL-----SGDNNNDYPSIEHHLDNSNKSVTNESQVA CRK7_Spur --SLVTPGVKAALMQMIAQQGL-----SE-LGIDNQPVDP--N--L-----------PQ- CC1G_14638_Ccin ------------------------------------------------------------ AqueK102_Aque ----LN------------------------------------------------------ CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe ---------------------------------------------------------NL- CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe --SL--------------------EAQRT-DGLPALVNDL--F--L-----------VS- CRK7_d_Smoe TATA-------------------------------------------------------- CG7597_Dmel ------------------------------------------------------------ CRK7_Mmus HPNRTY--GNTDGPETGFSSADTDER------------------------SSGPALTESL CHED_Mmus DYKDNF--GS-SFSAAPYVSSDGLGSSSAAAPLEARSFIGNSDIQSLDNYSTASSHTGGP B0285.1_Cele --------------------------------------------------------GDEL CTK1_Scer ------------------------------------------------------------ CRK7_Hsap RPNRTY--GNTDGPETGFSAIDTDER------------------------NSGPALTESL CHED_Hsap DYKDNF--GSSSFSSAPYVSNDGLGSSSA-PPLERRSFIGNSDIQSLDNYSTASSHSGGP DDB0229428_Ddis -P------------------------------QQG-------------------GGGNRP DDB0229428_C2d_Ddis -P------------------------------QQG-------------------GGGNRP 11773_Tthe QPNQSSKFNSFS-GLASLVQKQGSVDRQVHIPLEN-------------------SGHKKQ CRK7_Spur ------------------------------PPE----------------------PSLPP CC1G_14638_Ccin ------------------------------------------------------------ AqueK102_Aque -----------------------------------SSLA--------------------- CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe ------------------------------RSVL----------------------KAA- CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe ------------------------------SPLLAENFVP----------------GTR- CRK7_d_Smoe ------------------------------------------------------------ CG7597_Dmel ------------------------------------------------------------ CRK7_Mmus VQTPV----K---------NRTFSGSVSHLGESNSYQGTGSVQFPGDQDLRFT------- CHED_Mmus PQTSA----F---------TESFASSVA--GYGDIYLNAGPMLFSGDKDHRFE------Y B0285.1_Cele EEIKI---------------SDF------------------------------------- CTK1_Scer ------------------------------------------------------------ CRK7_Hsap VQTLV----K---------NRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFA------- CHED_Hsap PQPSA----F---------SESFPSSVA--GYGDIYLNAGPMLFSGDKDHRFE------Y DDB0229428_Ddis PQSQQ----N---------KNN------------------------------------F- DDB0229428_C2d_Ddis PQSQQ----N---------KNN------------------------------------F- 11773_Tthe VEDEDDDYENQSTAQVHKKQSN--------------------------LSMLTSNASTFM CRK7_Spur PD-NA----P----------------------QDPFLPQSKAIFPSGQ------------ CC1G_14638_Ccin ------------------------------------------------------------ AqueK102_Aque -------------------------------------DGGSVPAPGSTDERLH------L CRK7_c_Smoe ------------------------------------------------------------ CRK7a_Smoe ---------------------------------DRKH-------------ELDSRR-SDV CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe ---------------------------------EPDVPLGSLAPPR----LLRKRH-RRV CRK7_d_Smoe -------------------------------------------ATAKRDEQQQLKASPS- CG7597_Dmel ------------------------------------------------------------ CRK7_Mmus -RVPLAL-HSVVGQPFL-----KSEGNSNSVVHAETKLQNYGELGPGTTGANSSGTTLQW CHED_Mmus SHGPITV-LTNSNDPST-----GPE--STHPLPAKMHNYNYGGNLQENPGGPSLMHGQTW B0285.1_Cele ---------------------------------------IF------------------- CTK1_Scer ------------------------------------------------------------ CRK7_Hsap -RVPLAL-HPVVGQPFL-----KAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHW CHED_Hsap SHGPIAV-LANSSDPST-----GPE--STHPLPAKMHNYNYGGNLQENPSGPSLMHGQTW DDB0229428_Ddis --------------------------------P--------------------------- DDB0229428_C2d_Ddis --------------------------------P--------------------------- 11773_Tthe YNS----INNNNDDPIINHLSKINQ--K-RSPP--------------------------- CRK7_Spur -------------------------YCKED--PSKAS----GSGDRANSVGAGKSKGKNW CC1G_14638_Ccin ------------------------------------------------------------ AqueK102_Aque K---QVIA-----------------KAQRSLIEEITQTLGKGRGGRGEVPMVAS----IT CRK7_c_Smoe ------------------------A----------------------------------- CRK7a_Smoe FRGPPNLPEAPAKDGAF-----GAR--DSQPTPAVTLSYRLLVNVLKY------------ CRK7_e_Smoe ------------------------------------------------------------ CRK7_b_Smoe FRGPREAAPASSETSGT----GGAK----------------------------------- CRK7_d_Smoe ---P----WQRSQ----------------APTP--------------------------- CG7597_Dmel ------------------------GATMVGDA CRK7_Mmus GGPAQS--YGKPYRGAARVLPRGG-RGRGVPY CHED_Mmus TSPAQGPGYSQGYRGHISTSAGRG-RGRGLPY B0285.1_Cele -----------------------Q-FSENKVN CTK1_Scer ---------------------NNN-NNDDDDK CRK7_Hsap GGPTQSSAYGKLYRGPTRVPPRGG-RGRGVPY CHED_Hsap TSPAQGPGYSQGYRGHISTSTGRG-RGRGLPY DDB0229428_Ddis ----------------TNNNSSSN-SRNPSHR DDB0229428_C2d_Ddis ----------------TNNNSSSN-SRNPSHR 11773_Tthe ----------------SEIYDINI-KKKIKED CRK7_Spur SSPFNRGGGRGGFKGSHRGNKKGPVGPGTGWS CC1G_14638_Ccin ----------------------------ESTA AqueK102_Aque GRPTQSFDYGNQSNKGLEEKAAAQ-LYDKDKD CRK7_c_Smoe ---------------------------ITQDF CRK7a_Smoe --------------------------FCFAGL CRK7_e_Smoe ------------------------------RT CRK7_b_Smoe ---------------------------REGSG CRK7_d_Smoe ---------------------KPW-ETATLAC