CLUSTAL W (1.83) multiple sequence alignment ChaK2_Mmus ---------MQVKKSWIEGVFYKRECNKFIPSSKDPHRCTPGCQICHNLVRCYCGRLIEE ChaK1_Mmus ---------M-SQKSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQ ChaK2_Hsap MKEQPVLERLQSQKSWIKGVFDKRECSTIIPSSKNPHRCTPVCQVCQNLIRCYCGRLIGD ChaK1_Hsap ---------M-SQKSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQ : :****:..: **** :*****:**** * **:*::*:**:****: : ChaK2_Mmus HHGLDRAWNLSVTE-------GHGDEQWSVEKHTVKSPTDTFGTINFQDGEHIHHSKYIR ChaK1_Mmus HACFTASLAMKYSDVKLGEHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVR ChaK2_Hsap HAGIDYSWTISAAK-------GKESEQWSVEKHTTKSPTDTFGTINFQDGEHTHHAKYIR ChaK1_Hsap HACFTASLAMKYSDVKLGDHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVR * : : :. :. .: *:******* :****::*.****.*.* :::**:* ChaK2_Mmus TSWDTKSDHLLHLMLKEWNMELPKLVISVHGGLQNFKISSKLKETFSQGLVKAAETTGAW ChaK1_Mmus LSYDTKPEIILQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAW ChaK2_Hsap TSYDTKLDHLLHLMLKEWKMELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETTGAW ChaK1_Hsap LSYDTKPEVILQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAW *:*** : :*:*:****:*************:*:* : .::*: :.:**:*** ***** ChaK2_Mmus IITEGINSGVSKHVGDALKAHSSKSLRKIWTVGIPPWGVIENQRELVGKDVVCMYQTLGN ChaK1_Mmus ILTGGVNTGVAKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQTLLN ChaK2_Hsap IITEGINTGVSKHVGDALKSHSSHSLRKIWTVGIPPWGVIENQRDLIGKDVVCLYQTLDN ChaK1_Hsap ILTGGVNTGVAKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQTLLN *:* *:*:**:******** *:*:* *** *:**.*******:.:*:*:***. **** * ChaK2_Mmus PLSKLTTLNCMHSHFILCDDGTVGMYGNEEKLRRNLEKHLSMQKIHTCSRQGVPVVGLVM ChaK1_Mmus PLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIF ChaK2_Hsap PLSKLTTLNSMHSHFILSDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQGVPVVGLVV ChaK1_Hsap PLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIF *****..** :****** ****** ** * :***:*** :. *:** ******.*:. ChaK2_Mmus EGGPNVILWVWETVKNKE--PVVVCEGTGRAADLLAFTYKHLEDGGILRPQVKEELFCLI ChaK1_Mmus EGGPNVILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTI ChaK2_Hsap EGGPNVILSVWETVKDKD--PVVVCEGTGRAADLLAFTHKHLADEGMLRPQVKEEIICMI ChaK1_Hsap EGGPNVILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTI ******** * * :::. ****************: :*: : * * .: :::. * ChaK2_Mmus QNMFNFSLRQSKHLFQILMECMVHKDSITIFDADSEEHQDLDLAILTALLKGTSLSISEQ ChaK1_Mmus KKTFNFGQSEAVHLFQTMMECMKKKELITVFHIGSEDHQDIDVAILTALLKGTNASAFDQ ChaK2_Hsap QNTFNFSLKQSKHLFQILMECMVHRDCITIFDADSEEQQDLDLAILTALLKGTNLSASEQ ChaK1_Hsap KKTFNFGQNEALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASAFDQ :: ***. :: **** :**** ::: **:*. .*:::**:*:**********. * :* ChaK2_Mmus LNLAMAWDRMDIAKKHILTYGQHWKPGALEQAMLDALVMDRVDFVKLLIENGVNLHRFLT ChaK1_Mmus LILTLAWDRVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVSFVKLLIENGVSMHKFLT ChaK2_Hsap LNLAMAWDRVDIAKKHILIYEQHWKPDALEQAMSDALVMDRVDFVKLLIEYGVNLHRFLT ChaK1_Hsap LILTLAWDRVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLT * *::****:****:*:: * *:* .:***** ******** ******* **.:*:*** ChaK2_Mmus IPRLEELYNTKQGPTNKFLRHLVQDVKQHTLLSSYRITLIDIGLVIEYLIGGAYRSSYTR ChaK1_Mmus IPRLEELYNTKQGPTNPMLFHLIRDVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTR ChaK2_Hsap IPRLEELYNTKQGPTNTLLHHLVQDVKQHTLLSGYRITLIDIGLVVEYLIGRAYRSNYTR ChaK1_Hsap IPRLEELYNTKQGPTNPMLFHLVRDVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTR **************** :* **::**** .* ..*:*********:***:* :**..*** ChaK2_Mmus KSFRILYNNLYRKHKSVSSFAQGLSQHSL-HQRHSLRNRKESSESTLHSQFFRTAQPYKS ChaK1_Mmus KRFRLIYNSLGGNNRRSGRNTS-SSTPQLRKSHETFGNRADKKEKMRHNHFIKTAQPYRP ChaK2_Hsap KHFRALYNNLYRKYK---------------HQRHSSGNRNESAESTLHSQFIRTAQPYKF ChaK1_Hsap KRFRLIYNSLGGNNRRSGRNTS-SSTPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRP * ** :**.* : : :.:.: ** :. *. *.:*::*****: ChaK2_Mmus KEKPEDSQKSKKKSKERQSLSEEPEAAGFIYPYNDLLVWAVLMKRQNMAMFFWQHGEEAT ChaK1_Mmus KMDASMEEGKKKRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESM ChaK2_Hsap KEKSIVLHKSRKKSKEQNV-SDDPESTGFLYPYNDLLVWAVLMKRQKMAMFFWQHGEEAT ChaK1_Hsap KIDTVMEEGKKKRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESM * .. . .:*::*:. ::**: * ** *:**:** ***** ** *:******: ChaK2_Mmus VKAVIASILYRAMAREAKESNMVDDTSEELKNYSEQFGQLALDVLEKAFKQNEPMAMKLL ChaK1_Mmus AKALVACKIYRSMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLL ChaK2_Hsap VKAVIACILYRAMAHEAKESHMVDDASEELKNYSKQFGQLALDLLEKAFKQNERMAMTLL ChaK1_Hsap AKALVACKIYRSMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLL .**::*. :**:** ***:*.:***:*****:**::*****:::**::*:*:* ***.** ChaK2_Mmus TYELKNWSNSTCLKLAVSGGLRPFVSHSCTQMLLTDMWMGRLKMRKNSWLKIIISILLPP ChaK1_Mmus TYELKNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPP ChaK2_Hsap TYELRNWSNSTCLKLAVSGGLRPFVSHTCTQMLLTDMWMGRLKMRKNSWLKIIISIILPP ChaK1_Hsap TYELKNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPP ****:*************. *****:*:******:*******:****** *:*:**::** ChaK2_Mmus MILTLEFKSKAEMSHVPQSQDF-QFTWNYSDQGLSNTKESACVKDYDLERGPDEKPDEPL ChaK1_Mmus AILMLEYKTKAEMSHIPQSQDAHQMTMEDSENNFHNITEEIPMEVFKEVKILDSSDGK-N ChaK2_Hsap TILTLEFKSKAEMSHVPQSQDF-QFMWYYSDQNASSSKESASVKEYDLERGHDEKLDENQ ChaK1_Hsap AILLLEYKTKAEMSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVFKEVRILDSNEGK-N ** **:*:******:***** *: *::. . .*. :: :. : *.. .: ChaK2_Mmus HLDLRNVPQSLPWTRRVYEFYSAPFVKFWFYTMAYLAFLMLFTYTVLVEMQPQPSVHEWL ChaK1_Mmus EMEIHIKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVKMEQLPSVQEWI ChaK2_Hsap HFGLESGHQHLPWTRKVYEFYSAPIVKFWFYTMAYLAFLMLFTYTVLVEMQPQPSVQEWL ChaK1_Hsap EMEIQMKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWI .: :. : ** **:.* ** **:***** *:***.****:*:.***:*: ***:**: ChaK2_Mmus VIIYIFTNAIEKVREICISEPSKFKQKVKMWLSEYWNLMETVAIGLFAVGFGLRWGH--- ChaK1_Mmus VIAYIFTYAIEKVREVFMSEAGKISQKIKVWFSDYFNVSDTIAIISFFVGFGLRFGAKWN ChaK2_Hsap VSIYIFTNAIEVVREICISEPGKFTQKVKVWISEYWNLTETVAIGLFSAGFVLRWGD--- ChaK1_Hsap VIAYIFTYAIEKVREIFMSEAGKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWN * **** *** ***: :**..*..**:*:*:*:*:*: :*:** * ** **:* ChaK2_Mmus ------PPLQTAGRLIYCIDIIFWFSRLMDFFAVNQHAGPYVTMIAKMAANMFYIVIIMA ChaK1_Mmus YINAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMA ChaK2_Hsap ------PPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMA ChaK1_Hsap FANAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMA . .*******::****: **:**:****:***** **.**.*******:*** ChaK2_Mmus IVLLSFGVARKAILSPKEPPSWRLARDIVFEPYWMMYGEVYASDIDVCSNETS----CPP ChaK1_Mmus LVLLSFGVPRKAILYPHEEPSWSLAKDIVFHPYWMIFGEVYAYEIDVCANDSTLPTICGP ChaK2_Hsap IVLLSFGVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQPS----CPP ChaK1_Hsap LVLLSFGVPRKAILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGP :*******.***** *:* *** **:****.****::***** :****:.:. * * ChaK2_Mmus GSFLTPFLQAVYLFVQYIIMVNLLIACFNNIYLDIKSISNKLWKYNRYRYIMTYHQKPWL ChaK1_Mmus GTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVL ChaK2_Hsap GSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIMTYHEKPWL ChaK1_Hsap GTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVL *::*********************** ***:**::::*** :***:**::**:**:** * ChaK2_Mmus PPPFILLNHLCLLLRGLCCRPAPQDQEEGDGGLKLYLTKDDLKKLHDFEEQCVEKYFHEK ChaK1_Mmus PPPLIILSHIVSLF---CCVCKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFDEK ChaK2_Hsap PPPLILLSHVGLLLRRLCCHRAPHDQEEGDVGLKLYLSKEDLKKLHDFEEQCVEKYFHEK ChaK1_Hsap PPPLIILSHIVSLF---CCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEK ***:*:*.*: *: ** :.::: . * **:*:::* ************ **.** ChaK2_Mmus TEGLNCSFEEQIRMTSERVSEMFFQLKEMNEKVSFIKDSLLSLDSQVGHLQDLSAITVDT ChaK1_Mmus DDKFNSGSEERIRVTFERVEQMSIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDT ChaK2_Hsap MEDVNCSCEERIRVTSERVTEMYFQLKEMNEKVSFIKDSLLSLDSQVGHLQDLSALTVDT ChaK1_Hsap DDKFHSGSEERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDT : .:.. **:**:* *** :* :*:**:.::*.:** ** *****:********:**** ChaK2_Mmus LKVLSAVDTLQEDEILLA-NRKHSTCRK-----------RPHSWTNVICAKVLSDMESCG ChaK1_Mmus LKTLTAQKASEASKVHNEITRELSISKHLAQNLIDDVPVRP-LWKKPSAVNTLSSSLPQG ChaK2_Hsap LKVLSAVDTLQEDEALLA-KRKHSTCKK-----------LPHSWSNVICAEVLGSMEIAG ChaK1_Hsap LKTLTAQKASEASKVHNEITRELSISKHLAQNLIDDGPVRPSVWKKHGVVNTLSSSLPQG **.*:* .: : .: .*: * .:: * *.: .:.*.. * ChaK2_Mmus KKKLQYYSMPPSLLRSLARSQLPPS-VQRGALVEVTHSKREASHVREEQEEREMEQRTTA ChaK1_Mmus DRESN----NPFLCNIFMKDEKDPQYNLFGQDLPVIPQRKEF----NIPEAGSSCGALFP ChaK2_Hsap EKKYQYYSMPSSLLRSLAGGRHPPR-VQRGALLEITNSKREATNVRNDQERQETQSSIVV ChaK1_Hsap DLESN----NPFHCNILMKDDKDPQCNIFGQDLPAVPQRKEF----NFPEAGSSSGALFP . : : . . : . * * : .::* : * . ChaK2_Mmus SGISHVRQAHSKYGQFLLVPSSG-KQVPLSLETPPHLFRSSEEAGIDGLVLEHIHQSDLT ChaK1_Mmus SAVSPPELRQRRHGVEMLKIFNKNQKLGSSPNSSPHMSSPPT---------------KFS ChaK2_Hsap SGVSPNRQAHSKYGQFLLVPSNL-KRVPFSAETVLPLSRPSV---PDVLATEQDIQTEVL ChaK1_Hsap SAVSPPELRQRLHGVELLKIFNKNQKLGSSSTSIPHLSSPPT---------------KFF *.:* . : :* :* . ::: * : : .. .. ChaK2_Mmus THLPQQTPAASHQALVAEHKDQHEAVTQMSDKPAKAEQDLLAFSGTPAPMTVTSLPSRAI ChaK1_Mmus VSTPSQPSCKSH--LESTTKDQEPI----------------------------------- ChaK2_Hsap VHLTGQTPVVSDWASVDEPKEKHEPIAHLLDGQDKAEQVLPTLSCTPEPMTMSSPLSQAK ChaK1_Hsap VSTPSQPSCKSH--LETGTKDQETV----------------------------------- . . *.. *. *::. ChaK2_Mmus SMQDEGGYVNWAFSENDETGVFSFKKKWKTCLASTCNSDSNPGGDYFLHTGGRSGLDNSR ChaK1_Mmus -------FYKAAEGDNIEFGAFV---------------------------GHRDSMDLQ- ChaK2_Hsap IMQTGGGYVNWAFSEGDETGVFSIKKKWQTCLPSTCDSDSSRSEQHQKQAQDSSLSDNST ChaK1_Hsap -------CSKATEGDNTEFGAFV---------------------------GHRDSMDLQ- : : .:. * *.* . * . ChaK2_Mmus RLAQSCEC-PAGPWTQARRSFWINPLCRDKALIKSHSFRFHKE-EKLRKTWKNNSHSKSL ChaK1_Mmus --------------------------------------RFKETSNKIRELLSN------- ChaK2_Hsap RSAQSSECSEVGPWLQPNTSFWINPLRRYRPFARSHSFRFHKE-EKLMKICKIKNLSGSS ChaK1_Hsap --------------------------------------RFKETSNKIKILSNN------- **:: :*: . ChaK2_Mmus ET-RSTWLKAKLLTKTRSLSKKKRKTQGLQVPVITVNACYQSDQLNAEPGETNTT-EEFS ChaK1_Mmus ----------------------------------------------------DTP-ENTL ChaK2_Hsap EIGQGAWVKAKMLTKDRRLSKKKKNTQGLQVPIITVNACSQSDQLNPEPGENSISEEEYS ChaK1_Hsap ----------------------------------------------------NTS-ENTL . . *: ChaK2_Mmus KKWLSVSNFSQIGLEPYIYQKM------------KMKEIKRHTTQASDHLRQPQENRDKT ChaK1_Mmus KHVG-AAGYSECCKTSTSLHSVQE-SCSRRASTEDSPEVDSKAALLPDWLRDRPSNRE-- ChaK2_Hsap KNWFTVSKFSHTGVEPYIHQKM------------KTKEIGQCAIQISDYLKQSQEDLSKN ChaK1_Hsap KRVSSLAGFTDCHRTSIPVHSKQAEKISRRPSTEDTHEVDSKAALIPDWLQDRPSNRE-- *. : ::. . :. . *: : .* *:: .: . ChaK2_Mmus PTWNSGSTSLSRSFLTRSPNEVHKISTSLKSPQEPHHHYSAIERNNLMRLSQTIPFTPIQ ChaK1_Mmus --------------MPSEGGTLNGLASPFKPVLDTNYYYSAVERNNLMRLSQSIPFVPVP ChaK2_Hsap SLWNSRSTNLNRNSLLKSSIGVDKISASLKSPQEPHHHYSAIERNNLMRLSQTIPFTPVQ ChaK1_Hsap --------------MPSEEGTLNGLTSPFKPAMDTNYYYSAVERNNLMRLSQSIPFTPVP : . :. :::.:*. :.:::***:**********:***.*: ChaK2_Mmus LFTGEEVTIYKLEESSPLTLDKSMSSWSQHGRAAMIQVLSQEEMDGGLRKAMRVISTWSE ChaK1_Mmus P-RGEPVTVYRLEESSPSILNNSMSSWSQLGLCAKIEFLSKEEMGGGLRRAVKVLCTWSE ChaK2_Hsap LFAGEEITVYRLEESSPLNLDKSMSSWSQRGRAAMIQVLSREEMDGGLRKAMRVVSTWSE ChaK1_Hsap P-RGEPVTVYRLEESSPNILNNSMSSWSQLGLCAKIEFLSKEEMGGGLRRAVKVQCTWSE ** :*:*:****** *::******* * .* *:.**:***.****:*::* .**** ChaK2_Mmus DDVLKPGQVFIVKSFLPEVVQTWYKIFQESTVLHLCLREIQQQRAAQKLIYTFNQVKPQT ChaK1_Mmus HDILKSGHLYIIKSFLPEVINTWSSIYKEDTVLHLCLREIQQQRAAQKLTFAFNQMKPKS ChaK2_Hsap DDILKPGQVFIVKSFLPEVVRTWHKIFQESTVLHLCLREIQQQRAAQKLIYTFNQVKPQT ChaK1_Hsap HDILKSGHLYIIKSFLPEVVNTWSSIYKEDTVLHLCLREIQQQRAAQKLTFAFNQMKPKS .*:**.*:::*:*******:.** .*::*.******************* ::***:**:: ChaK2_Mmus IPYTPRFLEVSLVYCHSANQWLTIEKYMTGEFRKYNNNNGDEIAPTNTLEELMLAFSHWT ChaK1_Mmus IPYSPRFLEVFLLYCHSAGQWFAVEECMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWT ChaK2_Hsap IPYTPRFLEVFLIYCHSANQWLTIEKYMTGEFRKYNNNNGDEITPTNTLEELMLAFSHWT ChaK1_Hsap IPYSPRFLEVFLLYCHSAGQWFAVEECMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWT ***:****** *:*****.**:::*: **************** *******:******** ChaK2_Mmus YEYTRGELLVLDLQGVGENLTDPSVIKPEDKQSRGMVFGPANLGEDAIRSFIAKHRCNSC ChaK1_Mmus YEYTRGELLVLDLQGVGENLTDPSVIKAEEKRSCDMVFGPANLGEDAIKNFRAKHHCNSC ChaK2_Hsap YEYTRGELLVLDLQGVGENLTDPSVIKPEVKQSRGMVFGPANLGEDAIRNFIAKHHCNSC ChaK1_Hsap YEYTRGELLVLDLQGVGENLTDPSVIKAEEKRSCDMVFGPANLGEDAIKNFRAKHHCNSC ***************************.* *:* .*************:.* ***:**** ChaK2_Mmus CGKLRLPDLKRNDYSLSRTHCNLGF--GQTIEPTEELPERDKNRSSLEDHTRL ChaK1_Mmus CRKLKLPDLKRNDYTPDKIIFPQDESSDLNLQSGNSTKE---SEATNSVRLML ChaK2_Hsap CRKLKLPDLKRNDYSPERINSTFGL--EIKIESAEEPPARETGRNSPEDDMQL ChaK1_Hsap CRKLKLPDLKRNDYTPDKIIFPQDEPSDLNLQPGNSTKE---SESTNSVRLML * **:*********: .: . .::. :. .. : . *