CLUSTAL W (1.83) multiple sequence alignment Erk1_Ddis MEPEFDHFQSQM-------------------DSD-------------------------N 13785_Tthe MQNLSNFDSL-------------------------------------------------- 18504_Tthe MEHQVP--KE-------------------------------------------------- 18512_Tthe MDTANLVAKE-------------------------------------------------- 18725_Tthe MQQQQNQ----------------------------------------------------- 23186_Tthe MHPNQEQEKYGM-------------------QANRMNPTAGNMVDQSKQDIMYQNNFNGG 4173_Tthe MNLQAQQKTRKQSKGQILEIFEQIKPTHYIQDT---------------------ANGVST 6784_Tthe MKGQSMYQNS---------------------------------------------NNTSG 28107_Tthe MDIKRNMETT-------------------------------------------------- 23757_Tthe SK---------------------------------------------------------- 17883_Tthe MQNLPNFDEQ-------------------------------------------------- 13784_Tthe MYY--------------------------------------------------------- Erk1_Ddis THQSTMFNVQDNNAILMSGMENVLQSPR-------------------------------- 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe NNPNE-MNY--------------------------------------------------- 4173_Tthe KSFTK-QIRYQSQN------------PKMSNQKEKRNQEYLFHIGNHARTVSDILKFRYD 6784_Tthe NNFSY-MNYNQNQSI-----------PS-------------------------------- 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis --QLQAAAQ-AQQQAAAQAQQQQVQAQQVQAQQAQQQQQQQQN----------------- 13785_Tthe -------------------------------SQSQLQAFSQQN----------------- 18504_Tthe ------------------------------------------I----------------- 18512_Tthe ------------------------------------------V----------------- 18725_Tthe ------------------------------QQQAQQQQLQQQQQQQ-------------- 23186_Tthe ----------YR---------------N---NQLQQQNFIENNNNMYAANNINMVMPPQG 4173_Tthe QYK-----QTLG---------------QQEQQSEEQQRMQYQNQQS-------------- 6784_Tthe --S-----Y-YQ---------------QQQNQQSSQQPLQQQNQNIT------------- 28107_Tthe ------------------------------------------K----------------- 23757_Tthe ------------------------------------------------------------ 17883_Tthe -------------------------------SHSQQE-VLRQN----------------- 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe QYI---QDPNAQVIHQQQQYDDQNYYPMNGVNTQQNQQ---------------------- 4173_Tthe --IWQNSTTMIQQYQQYHQAQESNIKRSNTLSNLQSQKSGVKICNSASKQSEKNQNTQKL 6784_Tthe ------SYSRSQSRHSHHQSENVNISATNNTNNMQSQN---------------------- 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe ------------------------------------------------------------ 4173_Tthe LYKPAQIQSQKAISSILGSAESNISPIKKSYNEDLATAGDTRDNFASLSGGSLKSNPNNF 6784_Tthe ------------------------------------------------------------ 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe ----HQFVN--------------------------------------------------- 4173_Tthe SFQDRKYVSEKDYLSIQRNLFDSIDTQKNSSIQNQQCSSIVQSKKESDEIDFNKQSKLEK 6784_Tthe ----QKYVK--------------------------------------------------- 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe ------------------------------------------------------------ 4173_Tthe QNNQTFNKEDRLLQSPASLHLNQKSQSQDYLAQKNPTQQQQMSPHLIQPSHLLFVDSQQN 6784_Tthe ------------------------------------------------------------ 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis -------------QQ-----------------------------Q--------------- 13785_Tthe -------------PL-----------------------------R--------------- 18504_Tthe -------------IE-----------------------------Y--------------- 18512_Tthe -------------VE-----------------------------Y--------------- 18725_Tthe -------------QQ-----------------------------H--------------- 23186_Tthe --------MQGD-MQNQQILKQGNDFQQIQYMMGGGEGVQIDHQYT-------------- 4173_Tthe QNQINYPNQFIS-----------------------------SISQTSGQQNQTQEQFKID 6784_Tthe --------QSTSSMSHTQS-------------------------N--------------- 28107_Tthe -------------ID-----------------------------Y--------------- 23757_Tthe ------------------------------------------------------------ 17883_Tthe -------------SS-----------------------------R--------------- 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe ------------------------------------------------------------ 4173_Tthe QFKNNQINNNQKFLNQINYSQYNSIPSLDISQAQNKEGIINTDIKPIQKYQENLQSTSTI 6784_Tthe ------------------------------------------------------------ 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis --------------------------------Q-----QQQ------------------- 13785_Tthe --------------------------------F-----LSF------------------- 18504_Tthe --------------------------------Y-----KPY------------------- 18512_Tthe --------------------------------Y-----QPY------------------- 18725_Tthe --------------------------------Q-----QAQ------------------- 23186_Tthe ------------------------------MYNQL---QNH------------------- 4173_Tthe ETNQLAQANKITESKFTNFAKSNDQSQMQSASDIYSFNQPYSTSQISSQILSTERQFKIK 6784_Tthe --------------------------------QVY---QNS------------------- 28107_Tthe --------------------------------S-----K-Y------------------- 23757_Tthe ------------------------------------------------------------ 17883_Tthe --------------------------------Y-----LSF------------------- 13784_Tthe ------------------------------------------------------------ Erk1_Ddis --------QNQQ------------------------------------------------ 13785_Tthe --------QYTE------------------------------------------------ 18504_Tthe --------ENKK------------------------------------------------ 18512_Tthe --------RHK------------------------------------------------- 18725_Tthe --------QHQE------------------------------------------------ 23186_Tthe --------QFDQNY-------------------------------G-MN----------- 4173_Tthe LTKITKDSQISEEYQINKSPSSFTQLENKQDLLIKFAEARKQEHLNNLYDDAQSDFSKTP 6784_Tthe --------QLRENY-------------------------------NNLS----------- 28107_Tthe --------INE------------------------------------------------- 23757_Tthe ------------------------------------------------------------ 17883_Tthe --------QYTE------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe ----------------------------------------ND------------------ 4173_Tthe QTNKSEVIKRFKASQIFDQNQSQANSKPSQNKSSQIYYNNNSQYDFANSVKEINNEHKYT 6784_Tthe ----------------------------------------NN------------------ 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe ------------------------------------------------------------ 4173_Tthe NLMSSAQQQNLSHQIPTLSGMGRINNFIRKSQEGNKQSNYFTQISDSQIQNAGNVTKQSA 6784_Tthe ------------------------------------------------------------ 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe ------------------------------------------------------------ 4173_Tthe SFNPNYHLLESYTNSLVKQNNNETLNPLNTQNQIKNLIDYNSPKQNIQNIQASGLYNQSS 6784_Tthe ------------------------------------------------------------ 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe --------------LKPATVNSQYPQIGNPNYQ--------------S------------ 4173_Tthe FQQETKSSLSMIKNI---------------FESTLNNQENPSNQNLISSSPKNLELNIIL 6784_Tthe --------------SNAKSSQIQSSQTGNIRPSTVANILNNNSTNKIS------------ 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ----------------NQQQQQNQQQQ--------------------------------- 13785_Tthe ----------------ND------------------------------------------ 18504_Tthe ----------------SN------------------------------------------ 18512_Tthe ----------------SN------------------------------------------ 18725_Tthe ----------------KP--QKPI------------------------------------ 23186_Tthe ---------AQFYQKQQH--LNTLQEQ--------------------------------- 4173_Tthe SKYQSNKEKQ------------------------------------NLRQSSQFQQQTPS 6784_Tthe ---------Q------NT--IQNL--KQTNQVIPNNSKVNNENRVQN------------- 28107_Tthe ----------------KP------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ----------------NN------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe ------------------------------------------------------------ 4173_Tthe IQLETKNSFAKSIDQHFSQQNTRLSNTLAELNQSSQVKNSLTVLENQKIQQIMDDIQAKI 6784_Tthe ------------------------------------------------------------ 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe ------------------------------------------------------------ 4173_Tthe SLKKSQSLEQSGIAMQSSSNKFSQYFEKKTSNSQVIDNGMNEQNGLIVSFANNSLVGQST 6784_Tthe ------------------------------------------------------------ 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe ------------------------------------------------------------ 4173_Tthe IESSKNIANQMNYYINSASQIVIDEAYNKQKIEKNPVSAQFILQDNQTATSQTDSKKDIE 6784_Tthe ------------------------------------------------------------ 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe ------------------------------------------------------------ 4173_Tthe NPTSQNNYNLTLEGEQNQSDNPPSERKKMHADFSSDKSQKGEQDKTFDSENRDEMSIKQT 6784_Tthe ------------------------------------------------------------ 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe ------------------------------------------------------------ 4173_Tthe TQFEKKAETLSNTYDMSQLLCQTPLQQHGQHIRLMSGGNMEHLTLNNSIQSTFPFEQIQS 6784_Tthe ----------------------------------------------N---------TITS 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ----------------------SQQMTQQQL----------------------------- 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe ----------------------NQKQNNQEV----------------------------- 4173_Tthe NQTTSYNNYSNFTTSNNLQSANNHQSKNQEVGLNLQNSFDNGEQNIQIQVKSSQITRQSQ 6784_Tthe NQNTLTNNTNNVISSSINANNNNQQSNNQQI----------------------------- 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe ------------------------------------------------------------ 4173_Tthe EKREQQNPELELEKKSSKEIGRSQDSNLNTPQKCSENLQQLLNDNQQSKYNTPQTIVSAQ 6784_Tthe ------------------------------------------------------------ 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe ------------------------------------------------------------ 4173_Tthe PNELENQNIYEDQEVQYVQTATHNQERELQEYDKQNFTNPELLNQSKQLQESQNRDLQVQ 6784_Tthe ------------------------------------------------------------ 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe ------------------------------------------------------------ 4173_Tthe AAHHNKEKELQEYNNQNIANIEQLNKSKQLQESQKGDQNQQENSMLQGQIGENENEKQKN 6784_Tthe ------------------------------------------------------------ 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe ------------------------------------------------------------ 4173_Tthe IQKNINHVRFNNLVKQMQENSPCHNLGYYHYETINIDGKILKDVYQQTDNIEKKEISVQT 6784_Tthe ------------------------------------------------------------ 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe ------------------------------------------------------------ 4173_Tthe IEQSKRNSIFDECTKLFSPKMKFIEPEFKDNECMMLNMSNNSSQYDHKDSIKEQHEGGFN 6784_Tthe ------------------------------------------------------------ 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe ------------------------------------------------------------ 4173_Tthe YDQNQQKNLRKSDFFKQQPNQQQQQQTSSNGNHETGIINSSLYNSQKLASDNEEVIKRQY 6784_Tthe ------------------------------------------------------------ 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe ------------------------------------------------------------ 4173_Tthe QIYDKIFDAGELPVVDCTEQDNIFKEWYQSDQSNFKNRRYSNQISDSEKKNIQQQIDNIV 6784_Tthe ------------------------------------------------------------ 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ----------QQLM-------------P-------------------------------- 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ---------------------------Q-------------------------------- 23186_Tthe ----------K--L-------------K-------------------------------- 4173_Tthe NKRAYKNQQAL-MNQ----QKNSQSNQPQIGKNKSKQQTKVPNKQNQKSIKFNNKIETRN 6784_Tthe ----------S-SISASLKASTTNTKNQ-------------------------------- 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe ------------------------------------------------------------ 4173_Tthe IPKNSKQKNSAIPGNNTERVFERLYPKQVKQQQEQIFEIKKDTSKSKSKGRATSQFKTQE 6784_Tthe ------------------------------------------------------------ 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe ------------------------------------------------------------ 4173_Tthe EMDFIKINKQKVPYMMRKKVEDKFQLFKKAVEVNLENMIQDQKSHQIKSIVLDDEIKDQD 6784_Tthe ------------------------------------------------------------ 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe ------------------------------------------------------------ 4173_Tthe NLQEIYQRSLSNRTQKNLVSYDSQTMTNLARMDIQKDTSRVYKNNLSSYKQNPESGAKFL 6784_Tthe ------------------------------------------------------------ 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe ------------------------------------------------------------ 4173_Tthe IKRNLKELVQKVLKDANEFTHTNYIKLKALCSLQNIIVLAEHHIQEYLKDIMKVLVKFLD 6784_Tthe ------------------------------------------------------------ 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe ------------------------------------------------------------ 4173_Tthe YDDPEIPNTCKRISELLGIYVSSEVYIPLAISLIHDEEHKTAPKSLTKLLTIFSIMIRGE 6784_Tthe ------------------------------------------------------------ 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe ------------------------------------------------------------ 4173_Tthe TPKTIEGYLDTIMKTVTSVEKTFDNKIFMQIRESEEVLSGLYYIAKELINISGENISIYC 6784_Tthe ------------------------------------------------------------ 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe ------------------------------------------------------------ 4173_Tthe RPIFSLLLTVQATNTAGKDNQNEIQKTMLTLATYCGYSSIAELHANEVSMLLNEFTTNKS 6784_Tthe ------------------------------------------------------------ 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe ------------------------------------------------------------ 4173_Tthe YKTWQKYSKDRLKFEIIVRNCGEGLSKFIDIILEILQSCVELNQDIEVRMDALVLVEFII 6784_Tthe ------------------------------------------------------------ 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe ------------------------------------------------------------ 4173_Tthe CLQFKDVQEKLKENAQLILTKILIPSIVWKIGKPQIKIRKAGIINIYKLIENGLVTGDVL 6784_Tthe ------------------------------------------------------------ 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis -------PPPTSDT---------------------------------------------- 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe -------VPP-------------------------------------------------- 23186_Tthe -------QQPNSDT---------------------------------------------- 4173_Tthe MKCFKELMPPIKSCLSDDWAPDLRLAACKLAEKLFLEVRDHLEHIHISENYQLLLERLDD 6784_Tthe -------IQK-------------------------------------------------- 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe ------------------------------------------------------------ 4173_Tthe SQDVIRVEIFKTFTVIFGAPALKESPSIFEYMVKAIFIHLDDQNEDVQMGAYNTLKFAAR 6784_Tthe ------------------------------------------------------------ 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ---------------------------------SNFNDNISY-FVYGSQFTVPRRYSIV- 13785_Tthe --------------------------------------LHSF-NYYTSVYKIEKRYRIL- 18504_Tthe --------------------------------------IRVQNVLSASKFEMDDNYSII- 18512_Tthe --------------------------------------FTVT-QVHGSVFNIDERYRIL- 18725_Tthe -------------------------------------GKHKF-DCGQTIFVVDEKYEYI- 23186_Tthe ---------------------------------EDP-YFNSI-FIFQNRFDVPKKYQLL- 4173_Tthe INPAKIKEEPQQQLAAQNQLKPKQGHFYQKGKPFVKKGRQLS-DISGTYLVVYDHYQIV- 6784_Tthe -------------------------------------KRKTF-ECGGTAFSVDDHYEFH- 28107_Tthe --------------------------------------FTKW-KLNDIEFYMESSIQNLQ 23757_Tthe ----------------------------------------SY-QQNGITFTTGERYEVD- 17883_Tthe --------------------------------------LYSF-KDREKVYKIEKRYQIL- 13784_Tthe ------------------------------------------------------------ Erk1_Ddis KCIGHGAYGVVC-SAKDNL------TGEKVAIKKISKAFDNLKDTKRTLREIHLLRHFKH 13785_Tthe KQIGFGF-NPTF-TAIDQEY------GQKVIIEVIKIENDDLIYMNQLIRQIKIENHFKH 18504_Tthe DSIGQGAYGIVV-AARDLNCQ--DEENNLVAIKKIEKAFEHKIFTKRTLRELRLLRLLKH 18512_Tthe EKIGQGAYGVVS-AAIDQV------KRKSVAIKKIEKAFDQRIYTKRTLRELKLLRLLTH 18725_Tthe KQIGYGAYGVVC-SAVNKEN------GSKVAIKKVQNAYDDLIDAKRIVREIKLLKFFEH 23186_Tthe VPIGIGGYGVVA-KAFDQEK------QDFVAIKKIFKPFLNPLETKRILREIKILKALEH 4173_Tthe KRIGDGAYGVVF-KAIDKSK-----NNEIVAIKKVSDAFLDPRDAKRILREIKLLKFCNH 6784_Tthe KQIGHGAYGVVC-SGVDTKC------NKKIAIKKITNAFEDLVDAKRIVREIKMLKFFDH 28107_Tthe IKAGQGTFGVVV-ACQDKEKEFFDEDSDFVAIKKIERAFEHTQYAIRTIREIKLQRMLAH 23757_Tthe KLLGSGAYGQVV-RAKDKKN-----QNQYVAIKKLHK-IEDVIDAKRVLREIRILRYLVH 17883_Tthe RLIWRDTNISFCLAAIDREY------GQKVFIKVIKLEECILKYIIQAIRSIKIENHFQH 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ENLISIKDILKPNS--KEQFEDVYIVSELMDTDLHQIITSPQPLSDDHCQYFVYQMLRGL 13785_Tthe ENISSNLHIMM-------ESKNLYIVREFIDTDLHRVNFSKQELTDDHIQYFTYQILSAL 18504_Tthe ENIIGINTLLLPRS--REKFEDIYVVSELMETDLASIIKSEQPLTDEHCQFFLYQILRGL 18512_Tthe ENVIGLESILLPKS--REEFDDIYCVSELMETDLQQIIKSDQQLTQDHCKFFIYQILRGL 18725_Tthe DNIISLLDVIKPNA--PVGDEDIYMVFDLMETDLHRVIYSRQELSDEHIQYFVYQILRGL 23186_Tthe DNIISIRDVLSPVP--KEKLEDIYIISQLMDTDLHQIIASDQILSEDHIQFFIYQLLCGL 4173_Tthe PNIIKLKDIIKPEM--PTGYKDIYLVLEYMEIDLDKTINSEQALSPKIIKNLMWQLLNGI 6784_Tthe ENIIALHDIIVPEQ--RTDYNDIYIVTELMETDLHRVIYSRQELTDDHIQYFLYQTLRGM 28107_Tthe ENLL------LPKS--REQMNDIYLVEPLMTSDLRAIINSQNEINEEHIQFLMYQIIRGL 23757_Tthe ENILQLSDILYDDEDENQEFGTIYLVTNYMEIDLYQVIKSDQKLSDQHIQYIIYQILKGL 17883_Tthe ENINSNLHIMM-------ESKNLYIVKELMDINLKDVTFSRQELTDEHIKWFVYQILKAL 13784_Tthe ----------------------------------------------------LLN-IKSS : : . Erk1_Ddis ----------KHIHSANVLHRDLKPSNLLINEDCLLKICDLGLARVEDAT---------- 13785_Tthe ----------FFLHSQNVYHTQLRLSNILLNKNCDLKISRFIGTNF----PN-------- 18504_Tthe ----------KYIHSAKVVHRDLKPRNLLVNSNCDLKICDFGLARTIIPGLKC------- 18512_Tthe ----------KYIHSANVIHRDLKPRNLLVNSNCDLKICDFGLARSVAN----------- 18725_Tthe ----------LYIHSANVIHRDLKPSNILLNKNCDLKICDFGLARGFEEP-G-------- 23186_Tthe KYVNQIYYFLKYIHSAGVFHRDLKPGNLLVNSDCVLKICDFGLARTVDTKVNV------- 4173_Tthe ----------FYMHSADIIHRDIKPSNILLNKNCTLKLADMNLARKFDVEQSSIT----- 6784_Tthe ----------LYIHSANVMHRDLKPSNILVNKNCDLKVCDLGLARGFEFDEE-------- 28107_Tthe ----------KYMHSAQIVHRDLKPKNVLSNEQGDLKICDFGFARHIQKN---------- 23757_Tthe ----------KYLHSANIIHRDLKPSNLLATEKCAIRMCDFGLSRSIEDEQKQEQQLVRN 17883_Tthe ----------NFLHSQNVYHTELTARDILLKENCDLKITGFIHSNF----PH-------- 13784_Tthe ----------FFLHSQNVYLYVMKRDSILLNQNCELKISDFLGAKF----PN-------- .:** : : .:* ... ::: : :. Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe ------------------------------------------------------------ 4173_Tthe ------------------------------------------------------------ 6784_Tthe ------------------------------------------------------------ 28107_Tthe ------------------------------------------------------------ 23757_Tthe LILFFSFIILMHNLHKQTNKQINKKTNKPNQYLFQTLLSYSLKQFIHNCNQFSLYEFYTV 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ----------HQGFMTEYVATRWYRAPEVILSWNKYTKAIDIWSVGCIFAELLGRKPLFQ 13785_Tthe ------------EIYSQYITSDYFLSPQQILNLPKNLSKTDIWHVGVIILGLINRDTFFS 18504_Tthe ----------RAGMLTDYVATRWYRAPELLLSWRDYDEKVDVWSVGCIFAELLRRKPFLP 18512_Tthe ----------TKNDLTDYVTTRWYRPPELLLSWTDYTCAMDVWSVGIIFAELIKRKPLLP 18725_Tthe ------------ESLTEYVITRWYRAPEVILNASEYNQAVDIWSVGCITAELLGRTPLFP 23186_Tthe -----------LVLMTEYVATRWYRAPELLLSWNKYTTAIDMWAVGCIFSELYMRKPLLP 4173_Tthe -----EQQISLNLYFTTYVVTRPYRAPEILLSTENYSKPIDIWSAGCIFAEMMGRKTIFK 6784_Tthe ------------DGKTEYVVTRWYRAPEVILKASKYTKSIDVWSIGCIFAELLGRTPLFP 28107_Tthe ----------RVNDLSEYVTARWYRAPEILLSYKKYDIAVDMWSCGIIMAELLKRQPIIR 23757_Tthe NKKQASKQI-NTCQLTEYVVTRYYRAPEIMLSSHVYSKAVDIWSLGCTFAELISHQILFK 17883_Tthe ------------E--VNYYNKKGYYPPQRILELPENLSKTDIWHVGVIILQLLYGYPFFE 13784_Tthe ------------DFDKKYINTNSYLSPYYILGLPEDFSKTDIWNVGVIILELFQIKNIFS * : .* :* *:* * : :: Erk1_Ddis GKD------YIHQITLIIETIGSPSEEDICNIANEQA---RQFIRNMGNQPKVNFANMFP 13785_Tthe NLSNQLGGGYLGLINAIFSYIGTPSGEELLQYQ--DYKGLYQY---IIKYSKKSWQDVFP 18504_Tthe GID------TRNQIELIFEYLGTPSEQEINNIPREKF---RKMVKNMPKRQPKQFEKLFS 18512_Tthe GSS------SSDQLLRIFDLIGTPLENEIQMIPYDEY---RKFIRELPKREPKQFEKIFS 18725_Tthe GEN------YLDQVQRVIAVLGTPTQEDMAYIGNQDA---IKYIKSQPKRTKQSWQSLYP 23186_Tthe GES------YLNQLILTLNLTGTPSKEDLENIQSDRA---KQFIISLGNKAPKDLSKLIP 4173_Tthe GNS------YVNQLDRIIAIMGKPDFDKLSYKVDENL---KEYIKQLQEKQPENFYEIYK 6784_Tthe GKD------YLEQIQRIIAILGTPTPEELSYITNEGA---LKYLKSLPKRTKQSWENLYP 28107_Tthe GAS------TDDQMRQILQLIGSPDEYQVK---DPEY---KKLLSYFPYCPGKNFKLIFP 23757_Tthe ADN------YIKQIKLIFDKLGMPPEEDLQFIGNSNA---KQFVNTLAKKNSVKVSSFIN 17883_Tthe KRNR---GGRNGVLQAYFYSIGSPSEEDLSQYK--DYTEQYEQLKSLNQYCKKSWQDQFP 13784_Tthe DFCC---SASGGLLTNYFYYIGSPSKEDLDLLLEKGYKQQYNELLSLPFYRKQPWQVVFR : : * * .: : Erk1_Ddis KANPDAIDLLERMLYFDPSKRLTVEEALAHPYFQSLHDPSDEPICLH--KFSLNFEA--- 13785_Tthe DANPLLCDLLDKMLVFNEDKRYTVKECLQHPYFEDLYDLDDIDECDV--KFDHSQFQI-- 18504_Tthe KASKEAIDLLRKLLTFDFTKRITVDEALSHPYLSELHFPEDEPTCEPVSKLDFEFEE--- 18512_Tthe KAPKEALDLLKKMLTFDFNKRITVEEALKHPYLSDLHLPEDEPSRSEVPFYEFEFEM--- 18725_Tthe KANPLALDLLSKMLTFNPEKRYTVKECIEHPYFEGLHYPDEEPECEQ--VFDWSWDK--- 23186_Tthe NASPQAIDLISKMIVFNPDKRISAEEALKHPFFEGIRESEFEVEAKV--KFDFDFER--- 4173_Tthe SHDPLAIDLLYKMLAFDPKERWTVEQCLYHEYFKDFDKS-QIKACNH--KFDWTFDE--- 6784_Tthe NANLVGLDLLSKMLTFNPNDRYTIEECLAHPYFEGLHNPEDEPTCPE--VFDWAWDD--- 28107_Tthe NASSQCLDLLKKLLQIDPSQRITAEQALAHPFFEMLHDPSDEPDCEPINQAEFEYEN--- 23757_Tthe YENPLALDLIDKMLAINPSKRITADEALEHPYFQSIRDVQEEIKFTG--TINFDFET--- 17883_Tthe NANPLLCDLLDKMLVFNEDKRFSLKECFLHPYFEDLYIPDDFQQCNL--KFDHSQLQIGS 13784_Tthe RENPLLYDLLDKMLVFNEDKRYTVKECLQHPYFEDIYYQEDIYECDI--QFDHSQFQI-- **: ::: :: .* : .:.: * ::. : . Erk1_Ddis ---WDLNRDLLKELIYNEMLAY-HPED--------------------------------- 13785_Tthe ----GLNEDEIMKEIYFEVEKSYQKQQ--------------------------------- 18504_Tthe ---HNLTLQQLKDLIYEEILYY-HYPS--------------------------------- 18512_Tthe --HSNLTRQQYKDLVYEEILLY-HYPD--------------------------------- 18725_Tthe ---FTPTKEILQKMIYQEAKSF-HP----------------------------------- 23186_Tthe ---EDITLDELKDAIYQEMLKF-HPTFDENNKETYHIPIKRDSDLFTLDYDGSKIYIDYK 4173_Tthe ---IQERNDLIQRAIYNESCQF-HQDEPDATIEE-------------------------- 6784_Tthe ---FELTKERLQGMVYDEAIDY-QKV---------------------------------- 28107_Tthe ---YDLNDQQLKDILYEEILLY-NSPE--------------------------------- 23757_Tthe --DSEITIESLRKQILEEVNHF-RQV---------------------------------- 17883_Tthe NEDEDIDKEEVMKDIYFEVEKSYQKQQ--------------------------------- 13784_Tthe ----GLSKNEVMKEIYFEVEKSCLKQQ--------------------------------- : : * Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe LGQNDQPQQVVQNIQQINEKMVKDIIGVDGNGKMIQDQQFIQMPYYNNTIFSPSQVEQQN 4173_Tthe -------------------------------------------------------V-E-- 6784_Tthe ------------------------------------------------------------ 28107_Tthe ------------------------------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ---PQ--APYYTDL------N------N-----------------------PNFN----- 13785_Tthe ---KQKLKRYQIQI------I------Q-----------------------NIAF----- 18504_Tthe ---FK--QEYETKK------A------N-----------------------GQSL----- 18512_Tthe ---FK--KKYLDKI------Q------N-----------------------NQSV----- 18725_Tthe ------------------------------------------------------------ 23186_Tthe YQHYQ--QQQQQLYQQNYNVQQQQHQTDTQNIE-------YQQQQQQPHLQHQAVFNHEG 4173_Tthe -QHYK--Q-QQQIIQQK--I-AQQHAANANSQQFLKTNQQFQM-NLEKLAASQPLINPIN 6784_Tthe ----K--ATQQQQY---------------------------------------------- 28107_Tthe ---FR--EQYYEKL------K------K-----------------------GQSV----- 23757_Tthe ----N--KVPPLKI------P------DLLALC--------------------------- 17883_Tthe ------LRRYQIQI------I------Q-----------------------NIAF----- 13784_Tthe ------LKRYQIQI------I------Q-----------------------NIAF----- Erk1_Ddis ------------------------------------------------------------ 13785_Tthe ------------------------------------------------------------ 18504_Tthe ------------------------------------------------------------ 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe GN-----------------------------QYMDIQQQQQQQQQ--------------- 4173_Tthe FNPNMQVPFFPMGRQPQVPPEAILLQMQNMQKNPML-QKQFQMMQGQQQTQMPLQKDFRN 6784_Tthe ------------------------------------------------------------ 28107_Tthe ------------------------------------------------------------ 23757_Tthe -------------------------------------EKRT-K----------------- 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis ------------LSRIQSSSELF------------------------------------- 13785_Tthe ------------QKHLADQIPLNP------------------------------------ 18504_Tthe ------------ISHIINNANRNV------------------------------------ 18512_Tthe ------------MQHIFDNANKNI------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe ----------------QQQYMMNQHYVD-------------------------------- 4173_Tthe PFNSHPLANLSQDKMKADSLPINPIQASAVQQNPLFVPGLHNFPPGFHPIKIGMQEQFKK 6784_Tthe ------------------------------------------------------------ 28107_Tthe ------------YSHIIGDVEDND------------------------------------ 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------QKHLAHQIPLNP------------------------------------ 13784_Tthe ------------QKHLADQIPLNP------------------------------------ Erk1_Ddis --------------------------------------------------------NLLQ 13785_Tthe ------------------------------------------------------------ 18504_Tthe --------------------------------------------------------PD-- 18512_Tthe ------------------------------------------------------------ 18725_Tthe ------------------------------------------------------------ 23186_Tthe ----Y------------------------------------------------NNNNQVF 4173_Tthe PNINNNTNGNTNQQKPNQNDQSPPKTDSESKASDTNKNNHNGQNNGDENGKQEKNDKKFN 6784_Tthe ------------------------------------------------------------ 28107_Tthe --------------------------------------------------------NDYD 23757_Tthe ------------------------------------------------------------ 17883_Tthe ------------------------------------------------------------ 13784_Tthe ------------------------------------------------------------ Erk1_Ddis -QQKQQ-IH--------------------------------------------------- 13785_Tthe --------K--------------------------------------------------- 18504_Tthe --PH--SSD--------------------------------------------------- 18512_Tthe --------V--------------------------------------------------- 18725_Tthe ------------------------------------------------------------ 23186_Tthe -INQQQ-EI--------------------------------------------------- 4173_Tthe KDNDQD-QEKQNNNNGEKDRKNSNNGLNQMSNQTTEEKENPESKSKMQNKESEMNRSQDF 6784_Tthe ------------------------------------------------------------ 28107_Tthe -DDDEEDEE--------------------------------------------------- 23757_Tthe --------A--------------------------------------------------- 17883_Tthe --------K--------------------------------------------------- 13784_Tthe --------K--------------------------------------------------- Erk1_Ddis -------------------------------QQVNQQSIKN 13785_Tthe -------------------------------LIFYNLYEDL 18504_Tthe -------------------------------DDQSDDDDEN 18512_Tthe -------------------------------DEEFSSDQDY 18725_Tthe ---------------------------------------IH 23186_Tthe -------------------------------DQNDTQMREE 4173_Tthe LKGSILSNSEEIEELPNIPEMRYKTLTFGPEQFNNNQKSAE 6784_Tthe -------------------------------QQQQSYENQC 28107_Tthe -------------------------------EDDDETKKTN 23757_Tthe -------------------------------IQEKANLHKK 17883_Tthe -------------------------------LIFYNLYEDL 13784_Tthe -------------------------------SIFYNLYEDL