CLUSTAL W (1.83) multiple sequence alignment rl_Dmel MEEFNSS----------------------------------------------------- ERK2_Mmus MAAAAAA----------------------------------------------------- ERK1_Mmus MAAAAAA----------------------------------------------------- mpk-1_Cele MPTWIPN----------------------------------------------------- SMK1_Scer MNCTLTD----------------------------------------------------- SLT2_Scer MADKIER----------------------------------------------------- KSS1_Scer MART-------------------------------------------------------- FUS3_Scer MPKR-------------------------------------------------------- Erk2_Hsap MAAAAAA----------------------------------------------------- Erk1_Hsap MAAAAAQ----------------------------------------------------- YKL161C_Scer MATDTER----------------------------------------------------- ERK1_Spur ------------------------------------------------------------ CC1G_02007_Ccin MQRRS------------------------------------------------------- AqueK118_Aque MATVKPP----------------------------------------------------- AqueK119_Aque MATNSFA----------------------------------------------------- AqueK120_Aque MATNSFA----------------------------------------------------- ERK-p2-2_Smoe MSKGGLKWPIRSVVLGWGQRRNSGESDCGVERRKWGGGVFRVPGATRTPRPRKQGMQQSE ERK-Un_Smoe MSLAAAR----------------------------------------------------- ERK5_b_Smoe QSGVA------------------------------------------------------- ERK-p1_a-2_Smoe ------------------------------------------------------------ ERK5_a-2_Smoe MAETE------------------------------------------------------- ERK-p1_b-1_Smoe MAQKVDP----------------------------------------------------- ERK7_Smoe MSEDVD------------------------------------------------------ ERK5_a-1_Smoe MAETE------------------------------------------------------- ERK5_c_Smoe ------------------------------------------------------------ ERK-p2-1_Smoe MQQSEAM----------------------------------------------------- ERK-p1_a-1_Smoe MATKMDP----------------------------------------------------- ERK-p1_b-2_Smoe MAQKVDP----------------------------------------------------- GK037_Glam MPLAVF------------------------------------------------------ rl_Dmel --G---SVV-----------NG-------------------------------------- ERK2_Mmus ------------------------------------------------------------ ERK1_Mmus --P---GGG-----------GGE---------------------PRGT------------ mpk-1_Cele --N---LCAQPTTRNAKPPSNGHPQATQQQSAPGSLAYRNSSNIPNGATNHVRQQKWQYT SMK1_Scer --N---TRAI----------NV-------------------------------------- SLT2_Scer ------------------------------------------------------------ KSS1_Scer ------------------------------------------------------------ FUS3_Scer ------------------------------------------------------------ Erk2_Hsap --G---A----------------------------------------------------- Erk1_Hsap --G---GGG------------GE---------------------PRRT------------ YKL161C_Scer ------------------------------------------------------------ ERK1_Spur ------------------------------------------------------------ CC1G_02007_Ccin ------------------------------------------------------------ AqueK118_Aque ------------------------------------------------------------ AqueK119_Aque --S---CSE-----------E--------------------------------------- AqueK120_Aque --S---CSE-----------E--------------------------------------- ERK-p2-2_Smoe AMEAAAAAA-----------EGN------------------------F------------ ERK-Un_Smoe --L---MIS--------------------------------------------------- ERK5_b_Smoe ------------------------------------------------------------ ERK-p1_a-2_Smoe ------------------------------------------------------------ ERK5_a-2_Smoe ------------------------------------------------------------ ERK-p1_b-1_Smoe --------------------P--------------------------------------- ERK7_Smoe ------------------------------------------------------------ ERK5_a-1_Smoe ------------------------------------------------------------ ERK5_c_Smoe ------------------------------------------------------------ ERK-p2-1_Smoe --EAAAAAA-----------EGN------------------------F------------ ERK-p1_a-1_Smoe --------------------P--------------------------------------- ERK-p1_b-2_Smoe --------------------P--------------------------------------- GK037_Glam ------------------------------------------------------------ rl_Dmel ----------TGSTEV--PQSN-------------------------------------- ERK2_Mmus ---------------------G-------------------------------------- ERK1_Mmus ----------AGVVPV--VPGE-------------------------------------- mpk-1_Cele RSGHRKMADGEAVI-S--TVNN-------------------------------------- SMK1_Scer ----------ASNLG---APQQ-------------------------------------- SLT2_Scer ---------------------H-------------------------------------- KSS1_Scer ------------------------------------------------------------ FUS3_Scer ------------------------------------------------------------ Erk2_Hsap ---------------------G-------------------------------------- Erk1_Hsap ----------EGVGPG--VPGE-------------------------------------- YKL161C_Scer ---------------------C-------------------------------------- ERK1_Spur ------------------------------------------------------------ CC1G_02007_Ccin ------------------------------------------------------------ AqueK118_Aque ------------------------------------------------------------ AqueK119_Aque --------------------DG-------------------------------------- AqueK120_Aque --------------------DG-------------------------------------- ERK-p2-2_Smoe ----------TGVLVH--SGRY-------------------------------------- ERK-Un_Smoe -----------GAVRRGGIEFRVILVQGFGWKLQLQACTRSAASSGMVRSRFETRCLLHW ERK5_b_Smoe ------------------------------------------------------------ ERK-p1_a-2_Smoe ------------------------------------------------------------ ERK5_a-2_Smoe ------------------------------------------------------------ ERK-p1_b-1_Smoe -----------GGIAH--PGKH-------------------------------------- ERK7_Smoe ------------------------------------------------------------ ERK5_a-1_Smoe ------------------------------------------------------------ ERK5_c_Smoe ------------------------------------------------------------ ERK-p2-1_Smoe ----------TGVLVH--SGRY-------------------------------------- ERK-p1_a-1_Smoe -----------NGYCP--PDKH-------------------------------------- ERK-p1_b-2_Smoe -----------GGIAH--PGKH-------------------------------------- GK037_Glam ------------------------------------------------------------ rl_Dmel ------------------AEVIRGQIFEVGPRYI-KLAYIGEGAYGMVVSADD--TL--T ERK2_Mmus ------------------PEMVRGQVFDVGPRYT-NLSYIGEGAYGMVCSAYD--NL--N ERK1_Mmus ------------------VEVVKGQPFDVGPRYT-QLQYIGEGAYGMVSSAYD--HV--R mpk-1_Cele ------------------VEEVHGQLFEVAPRYV-NLSYIGEGAYGMVASALD--TI--T SMK1_Scer ------------------RTIFAKERISIPGYYE-IIQFLGKGAYGTVCSVKFKGRS--P SLT2_Scer ------------------TFKVFNQDFSVDKRFQ-LIKEIGHGAYGIVCSARF--AEAAE KSS1_Scer ------------------------ITFDIPSQYK-LVDLIGEGAYGTVCSAIH--KP--S FUS3_Scer ------------------------IVYNISSDFQ-LKSLLGEGAYGVVCSATH--KP--T Erk2_Hsap ------------------PEMVRGQVFDVGPRYT-NLSYIGEGAYGMVCSAYD--NV--N Erk1_Hsap ------------------VEMVKGQPFDVGPRYT-QLQYIGEGAYGMVSSAYD--HV--R YKL161C_Scer ------------------IFRAFGQDFILNKHFH-LTGKIGRGSHSLICSSTY--TESNE ERK1_Spur --------------------------FDVGLLYT-ELEAIAQGALALCSSAVD--TR--H CC1G_02007_Ccin -------------------FTALNSVFCVDAQYE-FVKELGQGAYGCVVAARH--RQ--T AqueK118_Aque ------------------PEIVRGQAFDVGPRYS-NLSYIGEGAYGMVCSAVD--NQ--S AqueK119_Aque ------------------VLVLPGHYWRVGKRYK-DLEYLALGGNGLVCKAID--TY--T AqueK120_Aque ------------------VLVLPGHYWRVGKRYK-DLEYLALGGNGLVCKALD--TY--T ERK-p2-2_Smoe -----------------VQYNIFGNLFEVTAKYVPPIRPIGRGAYGIVCSAVN--SE--T ERK-Un_Smoe PWRSIRRSKFPKIWHRFRCFHAWISCRAVGPRYL-LHEHIGSGSYGDVCRATD--CQ--A ERK5_b_Smoe ---------------------NFITEYGEAQRYK-VLEVIGKGSYGVVCSAID--TR--T ERK-p1_a-2_Smoe ------------------------------------------------------------ ERK5_a-2_Smoe ----------------------FFTEYGEASRYK-ILEVIGKGSYGVVCSATD--MH--T ERK-p1_b-1_Smoe ------------------YYMLWRSLFEIDQRYA-PIKPIGKGAYGVVCSATN--SE--S ERK7_Smoe --------------------------KHVLRKYH-VCQKLGKGAYGIVWKAFD--RK--T ERK5_a-1_Smoe ----------------------FFTEYGEASRYK-ILEVIGKGSYGVVCSATD--MH--T ERK5_c_Smoe ---------------------NFITEYGEAQRYK-VLEVIGKGSYGVVCSAID--TR--T ERK-p2-1_Smoe -----------------VQYNIFGNLFEVTAKYVPPIRPIGRGAYGIVCSAVN--SE--T ERK-p1_a-1_Smoe ------------------YYMLWHSLFEIDTKYV-PIRPLGKGAYGVVCSADN--LE--T ERK-p1_b-2_Smoe ------------------YYMLWRSLFEIDQRYA-PIKPIGKGAYGVVCSATN--SE--S GK037_Glam --------------------NIKGTRFCVPDYYK-VTKALGAGAYGVVAEAVD--TR--T rl_Dmel NQRVAIKKISP-FEHQTYCQRTLREITILTRFK-HE-----NIIDIRDI--LRVDSI--- ERK2_Mmus KVRVAIKKISP-FEHQTYCQRTLREIKILLRFR-HE-----NIIGINDI--IRAPTI--- ERK1_Mmus KTRVAIKKISP-FEHQTYCQRTLREIQILLRFR-HE-----NVIGIRDI--LRAPTL--- mpk-1_Cele RDRVAIKKISP-FEHQTFCQRTLREIKILNRFK-HE-----NIINIQEI--IRSETV--- SMK1_Scer AARIAVKKISNIFNKEILLKRAIRELKFMNFFKGHK-----NIVNLIDL--EIV-TS--- SLT2_Scer DTTVAIKKVTNVFSKTLLCKRSLRELKLLRHFRGHK-----NITCLYDMDIVFYP-D--- KSS1_Scer GIKVAIKKIQ-PFSKKLFVTRTIREIKLLRYFHEHE-----NIISILDK--VRPVSI--- FUS3_Scer GEIVAIKKIE-PFDKPLFALRTLREIKILKHFK-HE-----NIITIFNI--QRPDSF--- Erk2_Hsap KVRVAIKKISP-FEHQTYCQRTLREIKILLRFR-HE-----NIIGINDI--IRAPTI--- Erk1_Hsap KTRVAIKKISP-FEHQTYCQRTLREIQILLRFR-HE-----NVIGIRDI--LRASTL--- YKL161C_Scer ETHVAIRKIPNAFGNKLSCKRTLRELKLLRHLRGHP-----NIVWLFDTDIVFYP-N--- ERK1_Spur GGKVAIKKISP-FEHQTYCQRTLREIKILTRFN-HE-----NIINIQDI--IKADTI--- CC1G_02007_Ccin GEGCAIKKITNINTKRILTKRCLREIRLLHHFRGHK-----NITCLYDMDIVFQP-N--- AqueK118_Aque LTKVAIKRITP-FEHQTYCQRTLREIKILTRFR-HE-----NIIGILDI--LKPPSM--- AqueK119_Aque DKRVVISKRDSLF-SKTYCQRDLRELQVISRLQ-KALGDDLPIPELIDI--VCEPANQPI AqueK120_Aque DKRVVLSKRDSLF-SKTYCQRDLRELQVLSRLQ-KALGDDLPLPELLDL--VCEPANQPL ERK-p2-2_Smoe NEEVAIKKIGNAFDNRIDAKRTLREIKLLRHMD-HE-----NIVAIRDI--IRPPSK--- ERK-Un_Smoe SLTVALKRVGDVLCCPLLAKRVLREVCIMRRLS-HR-----YVITLTDV--FISMSME-V ERK5_b_Smoe NEKVAIKKINDIFEHVSDATRILREIKLLRLLR-HP-----DVVEIKHI--LLPPSR--- ERK-p1_a-2_Smoe ------------------------------------------------------------ ERK5_a-2_Smoe GDKVAIKKINDIFEHVSDATRILREIKLLRLLR-HP-----DIVEIKHI--MLPPSR--- ERK-p1_b-1_Smoe GEKVAIKKITNAFENTTDARRTLREIRLLRHLY-HE-----NIIGIKDI--MKPVGR--- ERK7_Smoe NDVVALKKIFDAFQNSTDAQRTFREVMFLQEINDHE-----NVIKLTNV--LKA---E-- ERK5_a-1_Smoe GDKVAIKKINDIFEHVSDATRILREIKLLRLLR-HP-----DIVEIKHI--MLPPSR--- ERK5_c_Smoe NEKVAIKKINDIFEHVSDATRILREIKLLRLLR-HP-----DVVEIKHI--LLPPSR--- ERK-p2-1_Smoe NEEVAIKKIGNAFDNRIDAKRTLREIKLLRHMD-HE-----NIVAIRDI--IRPPSK--- ERK-p1_a-1_Smoe GDKVAIKKIGNAFENSIDALRTLREMRLLRYLQ-HE-----NVVGLLDI--MKPVGR--- ERK-p1_b-2_Smoe GEKVAIKKITNAFENTTDARRTLREIRLLRHLY-HE-----NIIGIKDI--MKPVGR--- GK037_Glam NTTVAIKKISNLFVHLVDSKRTLREITILRMLD-HE-----NIVKLLDV--LVPEDP--- rl_Dmel DQMRDVYIVQCLMET-DLYKLLKT-Q----RLSNDHICYFLYQILRGLKYIHSANVLHRD ERK2_Mmus EQMKDVYIVQDLMET-DLYKLLKT-Q----HLSNDHICYFLYQILRGLKYIHSANVLHRD ERK1_Mmus EAMRDVYIVQDLMET-DLYKLLKS-Q----QLSNDHICYFLYQILRGLKYIHSANVLHRD mpk-1_Cele DSLKDIYIVQCLMET-DLYKLLKT-Q----KLSNDHVCYFLYQILRGLKYIHSANVLHRD SMK1_Scer SPYDGLYCYQELIDY-DLAKVIHSSV----QLSEFHIKYFLYQILCGLKYIHSADVIHRD SLT2_Scer GSINGLYLYEELMEC-DMHQIIKSGQ----PLTDAHYQSFTYQILCGLKYIHSADVLHRD KSS1_Scer DKLNAVYLVEELMET-DLQKVINNQNSGFSTLSDDHVQYFTYQILRALKSIHSAQVIHRD FUS3_Scer ENFNEVYIIQELMQT-DLHRVISTQ-----MLSDDHIQYFIYQTLRAVKVLHGSNVIHRD Erk2_Hsap EQMKDVYIVQDLMET-DLYKLLKT-Q----HLSNDHICYFLYQILRGLKYIHSANVLHRD Erk1_Hsap EAMRDVYIVQDLMET-DLYKLLKS-Q----QLSNDHICYFLYQILRGLKYIHSANVLHRD YKL161C_Scer GALNGVYLYEELMEC-DLSQIIRSEQ----RLEDAHFQSFIYQILCALKYIHSANVLHCD ERK1_Spur EAMRDVYIVQSLMET-DLYKLLKT-Q----PLSNDHICYFLYQILRGLKYIHSANVLHRD CC1G_02007_Ccin GNFDEVYLYEELMEA-DLHAIIRSGQ----PLTDAHFQSFIYQTLCGLKYIHSANVLHRD AqueK118_Aque AEMKDVYIVQTLMET-DLYKLLKT-Q----HLSNDHICYFLYQILRGLKYIHSANVLHRD AqueK119_Aque GEGTKFYVVQEAKEG-TIEIILQADQ----LPSPEQVKILMYQLLRALKLFHSAGIIHRC AqueK120_Aque GEGTKFYVVQEAKEG-TLELLLQADQ----LPSPEQVKLLMYQLLRALKLFHSAGLLHRC ERK-p2-2_Smoe DEFNDVYIVYELMDT-DLHQIIRSNQ----QLTDDHCQYFLYQLLRGLKYVHSANVLHRD ERK-Un_Smoe SGGIDLYIATEFADGGDMYHL---RE----PLTPEHVKFLMWQLLTGMSYIHSCRVWHRD ERK5_b_Smoe REFKDIYVVFELMES-DLHQVIKAND----DLMPEHYQFFLYQLLRGLKFIHTANVFHRD ERK-p1_a-2_Smoe ---------------------------------------------RGLKYIHSANVLHRD ERK5_a-2_Smoe REFKDIYVVFELMES-DLHQVIKAND----DLTPEHYQFFLYQLLRALKYIHTANVFHRD ERK-p1_b-1_Smoe SSFNDVYLVYELMDT-DLHQIIRSSQ----ALTDDHCQYFIYQLLRGLKYVHSANVLHRD ERK7_Smoe -NDRDLYLVFEYMET-DLHAVIRAN-----ILEDVHKQYIMYQLFKSLKYLHSAGLLHRD ERK5_a-1_Smoe REFKDIYVVFELMES-DLHQVIKAND----DLTPEHYQFFLYQLLRALKYIHTANVFHRD ERK5_c_Smoe REFKDIYVVFELMES-DLHQVIKAND----DLMPEHYQFFLYQLLRGLKFIHTANVFHRD ERK-p2-1_Smoe DEFNDVYIVYELMDT-DLHQIIRSNQ----QLTDDHCQYFLYQLLRGLKYVHSANVLHRD ERK-p1_a-1_Smoe YTFNDVYLVYELMDT-DLHQIIRSSQ----PLTDEHYQFFIYQLLRGLKYIHSANVLHRD ERK-p1_b-2_Smoe SSFNDVYLVYELMDT-DLHQIIRSSQ----ALTDDHCQYFIYQLLRGLKYVHSANVLHRD GK037_Glam SNFDDLYVVFDFMQT-DMHKIISSKQ----DLSPDHMQYFVYQLLRGLKYLHSANCVHRD .:. .* . * rl_Dmel LKPSNLLLNKTCDLKICDFGLARIADPE------------------HDHTGFLTEY-VAT ERK2_Mmus LKPSNLLLNTTCDLKICDFGLARVADPD------------------HDHTGFLTEY-VAT ERK1_Mmus LKPSNLLINTTCDLKICDFGLARIADPE------------------HDHTGFLTEY-VAT mpk-1_Cele LKPSNLLLNTTCDLKICDFGLARVTDPQ------------------TDHTGFLTEY-VAT SMK1_Scer LKPGNILCTLNGCLKICDFGLARGIHAGFFKC-------------HSTVQPHITNY-VAT SLT2_Scer LKPGNLLVNADCQLKICDFGLARGYSEN-----------------PVENSQFLTEY-VAT KSS1_Scer IKPSNLLLNSNCDLKVCDFGLARCLASSS-DSR-------------ETLVGFMTEY-VAT FUS3_Scer LKPSNLLINSNCDLKVCDFGLARIIDESAADNS----------E-PTGQQSGMTEY-VAT Erk2_Hsap LKPSNLLLNTTCDLKICDFGLARVADPD------------------HDHTGFLTEY-VAT Erk1_Hsap LKPSNLLINTTCDLKICDFGLARIADPE------------------HDHTGFLTEY-VAT YKL161C_Scer LKPKNLLVNSDCQLKICNFGLSCSYSENH-----------------KVNDGFIKGY-ITS ERK1_Spur LKPSNLLLNTTCDLKICDFGLARIADPG------------------HDHTGFLTEY-VAT CC1G_02007_Ccin LKPGNLLVNADCELKICDFGLARGYTPGS-GTS----------R-AAGNQGFMTEY-VAT AqueK118_Aque LKPSNLLLNTTCDLKICDFGLARIADPE------------------QDHTGILTEY-VAT AqueK119_Aque IRSNDILIDADCDLRVCDFRLAAVNGIES-DP-------------NFELLRFTDSYRVEH AqueK120_Aque LRSNDLLLDADCDLRVCDFRLAAVNGLES-DP-------------NFELLRFTDSYRVEH ERK-p2-2_Smoe LKPSNLLLNANCDLKICDFGLARTTSE-----T-----------------DYMTEY-VVT ERK-Un_Smoe LKSENILLMADMSVKICDFGLSRSA-----------------------------EE-VVT ERK5_b_Smoe LKPKNVLANANCKLKICDFGLARVAFNDA-PTA-----------------IFWTDY-VAT ERK-p1_a-2_Smoe LKPGNLLLNANCDLKIADFGLARTGRE----KG-----------------QFMTEY-VVT ERK5_a-2_Smoe LKPKNILANADCKLKICDFGLARVAFNDA-PTAIFWTVSASNKGWTYLTLLFFKDY-VAT ERK-p1_b-1_Smoe LKPSNLLLNASCDLKICDFGLARTGSD----KG-----------------QFMTEY-VVT ERK7_Smoe IKPSNLLLDSDCRCKLADFGLARSVAQLK-DD--------------MGQAQVLTDY-VAT ERK5_a-1_Smoe LKPKNILANADCKLKICDFGLARVAFNDA-PTAIFWTVSVSNKGWTYLTLLFFKDY-VAT ERK5_c_Smoe LKPKNVLANANCKLKICDFGLARVAFNDA-PTA-----------------IFWTDY-VAT ERK-p2-1_Smoe LKPSNLLLNANCDLKICDFGLARTTSE-----T-----------------DYMTEY-VVT ERK-p1_a-1_Smoe LKPGNLLLNANCDLKIADFGLARTGRE----KG-----------------QFMTEY-VVT ERK-p1_b-2_Smoe LKPSNLLLNASCDLKICDFGLARTGSD----KG-----------------QFMTEY-VVT GK037_Glam LKPSNLLLNSDCALEICDLGLARLVDDHA-AKTKEL------KD-AEKHDTQMTEY-VAT ::. ::* .:.:: *: : rl_Dmel RWYRAPEIMLN-SKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSR ERK2_Mmus RWYRAPEIMLN-SKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ ERK1_Mmus RWYRAPEIMLN-SKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ mpk-1_Cele RWYRAPEIMLN-SKGYTKSIDVWSVGCILAEMLSNRPLFPGKHYLDQLNLILAVVGSPSN SMK1_Scer RWYRAPELLLS-NQPYSKSVDIWAVGCILAEFYARKPVFMGRDSMHQIFEIIKVLGTPDK SLT2_Scer RWYRAPEIMLS-YQGYTKAIDVWSAGCILAEFLGGKPIFKGKDYVNQLNQILQVLGTPPD KSS1_Scer RWYRAPEIMLT-FQEYTTAMDIWSCGCILAEMVSGKPLFPGRDYHHQLWLILEVLGTPSF FUS3_Scer RWYRAPEVMLT-SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHS Erk2_Hsap RWYRAPEIMLN-SKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ Erk1_Hsap RWYRAPEIMLN-SKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ YKL161C_Scer IWYKAPEILLN-YQECTKAVDIWSTGCILAELLGRKPMFEGKDYVDHLNHILQILGTPPE ERK1_Spur RWYRAPEIMLN-SKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQ CC1G_02007_Ccin RWYRAPEIMLS-FANYSTAIDVWSVGCILAELLGGRPIFKGRDYVDQLNQILHYLGTPSE AqueK118_Aque RWYRAPEIMLN-SKGYSKAIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILNVIGSPTE AqueK119_Aque LHYWAPEVLIN--EEITPVVDIWSAGCIFAELLTGKKVFGSSDVRGQLDLIVDLLGAPSP AqueK120_Aque LHYWAPEVLLN--EELTPVVDLWSAGCLFAELLTGKKVFGSSDVRGQLDLLVDLLGAPSP ERK-p2-2_Smoe RWYRAPELLLN-CSEYTAAIDVWSVGCIFMELLNREPLFPGRDYVQQLRLITELIGSPED ERK-Un_Smoe PSYRAPEVIMS-RGQYSSSIDIWSLGCIFWVSVSSNDI-----TILNLDVIFNVIGTPGW ERK5_b_Smoe RWYRAPELCGSFFSRYTPAIDIWSIGCIFAETITRKPLFPGKNVTHQLELITDLLGTPSQ ERK-p1_a-2_Smoe RWYRAPELLLS-CEDYTSAIDIWSVGCIFAELLGRKPIFPGKNYINQLKLIIDVIGSPKE ERK5_a-2_Smoe RWYRAPELCGSFFSKYTPAIDIWSIGCIFAEILTGKPLFPGKNVVHQLDLMTDMLGTPSA ERK-p1_b-1_Smoe RWYRAPELLLS-CEEYTSAIDMWSVGCIFAELLGRKPIFPGKDYIHQLKLIINTIGSPEE ERK7_Smoe RWYRAPEILLG-STNYTFGVDMWSSGCILGELLNGKPVFPGASTMNQIEKVLDLIGKPAS ERK5_a-1_Smoe RWYRAPELCGSFFSKYTPAIDIWSIGCIFAEILTGKPLFPGKNVVHQLDLMTDMLGTPSA ERK5_c_Smoe RWYRAPELCGSFFSRYTPAIDIWSIGCIFAETITRKPLFPGKNVTHQLELITDLLGTPSQ ERK-p2-1_Smoe RWYRAPELLLN-CSEYTAAIDVWSVGCIFMELLNREPLFPGRDYVQQLRLITELIGSPED ERK-p1_a-1_Smoe RWYRAPELLLS-CEDYTSAIDIWSVGCIFAELLGRKPIFPGKNYINQLKLIIDVIGSPKE ERK-p1_b-2_Smoe RWYRAPELLLS-CEEYTSAIDMWSVGCIFAELLGRKPIFPGKDYIHQLKLIINTIGSPEE GK037_Glam RWYRAPEIILG-WPQYGKPVDIFSVGCIFAELIARKPLFPGRDYIHQLHLILEVLGTPEK * ***: :*::: **:: . : :: : :* * rl_Dmel -DDLECIINEKARNYLE--SLPFK-PNVPWAKLFPNA--DALALDLLGKMLTFNPHKRIP ERK2_Mmus -EDLNCIINLKARNYLL--SLPHK-NKVPWNRLFPNA--DSKALDLLDKMLTFNPHKRIE ERK1_Mmus -EDLNCIINMKARNYLQ--SLPSK-TKVAWAKLFPKS--DSKALDLLDRMLTFNPNKRIT mpk-1_Cele -ADLQCIINDKARSYLI--SLPHK-PKQPWARLYPGA--DPRALDLLDKMLTFNPHNRID SMK1_Scer -DILIKFGTIKAWNLGKNSNNPVY-KKIPWSNIFPFA--SHEAINLIESLLHWDSTHRLN SLT2_Scer -ETLRRIGSKNVQDYIH--QLGFI-PKVPFVNLYPNA--NSQALDLLEQMLAFDPQKRIT KSS1_Scer -EDFNQIKSKRAKEYIA--NLPMR-PPLPWETVWSKTDLNPDMIDLLDKMLQFNPDKRIS FUS3_Scer DNDLRCIESPRAREYIK--SLPMY-PAAPLEKMFPRV--NPKGIDLLQRMLVFDPAKRIT Erk2_Hsap -EDLNCIINLKARNYLL--SLPHK-NKVPWNRLFPNA--DSKALDLLDKMLTFNPHKRIE Erk1_Hsap -EDLNCIINMKARNYLQ--SLPSK-TKVAWAKLFPKS--DSKALDLLDRMLTFNPNKRIT YKL161C_Scer -ETLQEIASQKVYNYIF--QFGNI-PGRSFESILPGA--NPEALELLKKMLEFDPKKRIT ERK1_Spur -DDLKCIINEKARAYLQ--GLPFK-SKIPLKSLFPKA--DNKALDFLERMLSFNPDKRIT CC1G_02007_Ccin -DTLRRVGSPRAQDYIR--SLPIR-PRISFSTLFPQA--NPLAIDLLSRMLCFDPARRIS AqueK118_Aque -KDLSCIRNEKAKSYLK--NLPFK-PTVPWSRLYPKA--DPKALDILGKMLTFNPDERIS AqueK119_Aque -EDLAFVKGDASRTALT--SVQN-SSP-TFEERFKNI--DPVARDLLKKMLVFNPSQRIT AqueK120_Aque -EDLAFVKGDASRTALT--SVQN-SSP-TFEERFKNL--DPVARDLLKKMLVFNPSQRLT ERK-p2-2_Smoe -ADLGFLRNDNARRYVR--QLQRY-PRQSFAHRFPNV--PPLAVDLVERMLVFNPQNRIS ERK-Un_Smoe -SDIESVPSESWRSYLK--HLPGR-VRNLTEQLLGYV--DQEALDLLFRMLAFNPGRRCT ERK5_b_Smoe -DVISRVRNEKARRYLS--TMSKK-SPVPFSEKFKNI--DPLARNLLQKMLAFDPKDRPS ERK-p1_a-2_Smoe -SQLGFISNHKARSYIR--SLPPT-PRVPLSRLYPHA--NPQALQLIERMLAFDPKERIT ERK5_a-2_Smoe -ESVARVRNEKARRYLS--GMRKK-TAIPFTQKFPNA--DPLALRLLERLLAFDPKDRPT ERK-p1_b-1_Smoe -DDLQFILSNKARSYIR--SLPFA-PKIPLERLYPRA--NPLALNLIDQMLVFDPKKRLT ERK7_Smoe -EDIAAFESPFAAAMIE--NMAITGPSRSFRKAFPSA--TPEAADLLRKLLHFNPQKRLT ERK5_a-1_Smoe -ESVARVRNEKARRYLS--GMRKK-TAIPFTQKFPNA--DPLALRLLERLLAFDPKDRPT ERK5_c_Smoe -DVISRVRNEKARRYLS--TMSKK-SPVPFSEKFKNI--DPLARNLLQKMLAFDPKDRPS ERK-p2-1_Smoe -ADLGFLRNDNARRYVR--QLQRY-PRQSFAHRFPNV--PPLAVDLVERMLVFNPQNRIS ERK-p1_a-1_Smoe -SQLGFISNHKARSYIR--SLPPT-PRVPLSRLYPHA--NPQALQLIERMLAFDPKERIT ERK-p1_b-2_Smoe -DDLQFILSNKARSYIR--SLPFA-PKIPLERLYPRA--NPLALNLIDQMLVFDPKKRLT GK037_Glam -ELLDRIASDSAKSYVL--ALKPS-APQDLSQKFPML--DEAGIDLLTRMLTLDPLKRIT . . :: :* :. * rl_Dmel VEE-------------------ALAHPYLEQYYDPGDEPVA------EVP---------- ERK2_Mmus VEQ-------------------ALAHPYLEQYYDPSDEPIA------EAP---------- ERK1_Mmus VEE-------------------ALAHPYLEQYYDPTDEPVA------EEP---------- mpk-1_Cele IEQ-------------------ALAHPYLEQYYDPGDEPVC------EEP---------- SMK1_Scer VEQ-------------------AISHPFLNEVRKPDDEPVCL-----QGP---------- SLT2_Scer VDE-------------------ALEHPYLSIWHDPADEPVCS--E----K---------- KSS1_Scer AAE-------------------ALRHPYLAMYHDPSDEPEYP--PL---N---------- FUS3_Scer AKE-------------------ALEHPYLQTYHDPNDEPEGE--PIPPSF---------- Erk2_Hsap VEQ-------------------ALAHPYLEQYYDPSDEPIA------EAP---------- Erk1_Hsap VEE-------------------ALAHPYLEQYYDPTDEPVA------EEP---------- YKL161C_Scer VED-------------------ALEHPYLSMWHDIDEEFSCQ--K----T---------- ERK1_Spur VEE-------------------ALAHPYLEQYYDPDDEVTV------IEQ---------- CC1G_02007_Ccin CEE-------------------ALNHPYLAVWHDPADEPNCD--S----I---------- AqueK118_Aque VDA-------------------ALAHPYLEQYYDPDDEPVA------EVP---------- AqueK119_Aque AEK-------------------ALEHEYLAEYHDPSEEPVYN--A--EKPLWKELLVSDQ AqueK120_Aque AEK-------------------ALEHEYLAEYHDPSEEPVYN--A--EKPLWKELLVSDQ ERK-p2-2_Smoe VTE-------------------ALAHPYLTNLHDVNDEPSCH------GP---------- ERK-Un_Smoe AEE-------------------ALSHIYVSNRL----------------Y---------- ERK5_b_Smoe ATEVKYSLTSEQVMLTRELDFQALADPYFQSMSHLQREPAAN--P--ISR---------- ERK-p1_a-2_Smoe VSE-------------------ALDHPYFNLVHDNHAGDVYQFRPDNIIP---------- ERK5_a-2_Smoe AEE-------------------ALADPYFRGLAKVEREPSAQ--P--ITK---------- ERK-p1_b-1_Smoe VTD-------------------ALEHPYLSMLHDAALEPSAS------AA---------- ERK7_Smoe AEQ-------------------ALQHPYVAQFHNPREEPSCN--R--L------------ ERK5_a-1_Smoe AEE-------------------ALADPYFRGLAKVEREPSAQ--P--ITK---------- ERK5_c_Smoe ATE-------------------ALADPYFQSMSHLQREPAAN--P--ISR---------- ERK-p2-1_Smoe VTE-------------------ALAHPYLTNLHDVNDEPSCH------GP---------- ERK-p1_a-1_Smoe VSE-------------------ALDHPYFNLVHDNHAGDVYQFRPDNIIP---------- ERK-p1_b-2_Smoe VTD-------------------ALEHPYLSMLHDAALEPSAS------AA---------- GK037_Glam VNE-------------------CLSHPYFEGIHDESDEPVYT--G---QP---------- .: . :. rl_Dmel ------------------------------------------------------------ ERK2_Mmus ------------------------------------------------------------ ERK1_Mmus ------------------------------------------------------------ mpk-1_Cele ------------------------------------------------------------ SMK1_Scer ------------------------------------------------------------ SLT2_Scer ------------------------------------------------------------ KSS1_Scer ------------------------------------------------------------ FUS3_Scer ------------------------------------------------------------ Erk2_Hsap ------------------------------------------------------------ Erk1_Hsap ------------------------------------------------------------ YKL161C_Scer ------------------------------------------------------------ ERK1_Spur ------------------------------------------------------------ CC1G_02007_Ccin ------------------------------------------------------------ AqueK118_Aque ------------------------------------------------------------ AqueK119_Aque NLEVLRSQLLKEVHELKAWLMGPEVEAPLVNGHPWHVGSRYRNLEFLTKGSNGSMCFATD AqueK120_Aque NLEVLRSQLIKEVHEIKAWLMGPEVEAPIVNGHPWHVGSRYRNLEFLTKGSNGSMCFATD ERK-p2-2_Smoe ------------------------------------------------------------ ERK-Un_Smoe ------------------------------------------------------------ ERK5_b_Smoe ------------------------------------------------------------ ERK-p1_a-2_Smoe ------------------------------------------------------------ ERK5_a-2_Smoe ------------------------------------------------------------ ERK-p1_b-1_Smoe ------------------------------------------------------------ ERK7_Smoe ------------------------------------------------------------ ERK5_a-1_Smoe ------------------------------------------------------------ ERK5_c_Smoe ------------------------------------------------------------ ERK-p2-1_Smoe ------------------------------------------------------------ ERK-p1_a-1_Smoe ------------------------------------------------------------ ERK-p1_b-2_Smoe ------------------------------------------------------------ GK037_Glam ------------------------------------------------------------ rl_Dmel ------------------------------------------------------------ ERK2_Mmus ------------------------------------------------------------ ERK1_Mmus ------------------------------------------------------------ mpk-1_Cele ------------------------------------------------------------ SMK1_Scer ------------------------------------------------------------ SLT2_Scer ------------------------------------------------------------ KSS1_Scer ------------------------------------------------------------ FUS3_Scer ------------------------------------------------------------ Erk2_Hsap ------------------------------------------------------------ Erk1_Hsap ------------------------------------------------------------ YKL161C_Scer ------------------------------------------------------------ ERK1_Spur ------------------------------------------------------------ CC1G_02007_Ccin ------------------------------------------------------------ AqueK118_Aque ------------------------------------------------------------ AqueK119_Aque TRTSSRVVLSKRDGLYSQEYSKRNLRELQLLTRLQRMYSDDYDPFPRLLDFLCYPQNLSG AqueK120_Aque TRTSSRVVISKRDGLYSQEYSKRNLREIQILTRLQRMYSDDYDPFPRIIDFICYPQNLSG ERK-p2-2_Smoe ------------------------------------------------------------ ERK-Un_Smoe ------------------------------------------------------------ ERK5_b_Smoe ------------------------------------------------------------ ERK-p1_a-2_Smoe ------------------------------------------------------------ ERK5_a-2_Smoe ------------------------------------------------------------ ERK-p1_b-1_Smoe ------------------------------------------------------------ ERK7_Smoe ------------------------------------------------------------ ERK5_a-1_Smoe ------------------------------------------------------------ ERK5_c_Smoe ------------------------------------------------------------ ERK-p2-1_Smoe ------------------------------------------------------------ ERK-p1_a-1_Smoe ------------------------------------------------------------ ERK-p1_b-2_Smoe ------------------------------------------------------------ GK037_Glam ------------------------------------------------------------ rl_Dmel ------------------------------------------------------------ ERK2_Mmus ------------------------------------------------------------ ERK1_Mmus ------------------------------------------------------------ mpk-1_Cele ------------------------------------------------------------ SMK1_Scer ------------------------------------------------------------ SLT2_Scer ------------------------------------------------------------ KSS1_Scer ------------------------------------------------------------ FUS3_Scer ------------------------------------------------------------ Erk2_Hsap ------------------------------------------------------------ Erk1_Hsap ------------------------------------------------------------ YKL161C_Scer ------------------------------------------------------------ ERK1_Spur ------------------------------------------------------------ CC1G_02007_Ccin ------------------------------------------------------------ AqueK118_Aque ------------------------------------------------------------ AqueK119_Aque PKQAELYVVQTAFDVNLADLLNQQRMTHDQLWCLMYSLLVSLKLLHSAGVVHRCLRPRHL AqueK120_Aque PKQAELYVVQTAFDVNLADILNQQRMTHDQIWCIMYSLLVSLKLLHSAGVVHRCIRPRHL ERK-p2-2_Smoe ------------------------------------------------------------ ERK-Un_Smoe ------------------------------------------------------------ ERK5_b_Smoe ------------------------------------------------------------ ERK-p1_a-2_Smoe ------------------------------------------------------------ ERK5_a-2_Smoe ------------------------------------------------------------ ERK-p1_b-1_Smoe ------------------------------------------------------------ ERK7_Smoe ------------------------------------------------------------ ERK5_a-1_Smoe ------------------------------------------------------------ ERK5_c_Smoe ------------------------------------------------------------ ERK-p2-1_Smoe ------------------------------------------------------------ ERK-p1_a-1_Smoe ------------------------------------------------------------ ERK-p1_b-2_Smoe ------------------------------------------------------------ GK037_Glam ------------------------------------------------------------ rl_Dmel ------------------------------------------------------------ ERK2_Mmus ------------------------------------------------------------ ERK1_Mmus ------------------------------------------------------------ mpk-1_Cele ------------------------------------------------------------ SMK1_Scer ------------------------------------------------------------ SLT2_Scer ------------------------------------------------------------ KSS1_Scer ------------------------------------------------------------ FUS3_Scer ------------------------------------------------------------ Erk2_Hsap ------------------------------------------------------------ Erk1_Hsap ------------------------------------------------------------ YKL161C_Scer ------------------------------------------------------------ ERK1_Spur ------------------------------------------------------------ CC1G_02007_Ccin ------------------------------------------------------------ AqueK118_Aque ------------------------------------------------------------ AqueK119_Aque LLTSEFDLALCDLRRSLMNHEPCGEEYNWTGSSTEGSWQYLSPQAVCYDEQTTACDLWSA AqueK120_Aque LLTSEFDLAICDLRRSIMNHEPCGEEYNWTGSSTEGSWQYLSPQAVCYDEQTTACDIWSA ERK-p2-2_Smoe ------------------------------------------------------------ ERK-Un_Smoe ------------------------------------------------------------ ERK5_b_Smoe ------------------------------------------------------------ ERK-p1_a-2_Smoe ------------------------------------------------------------ ERK5_a-2_Smoe ------------------------------------------------------------ ERK-p1_b-1_Smoe ------------------------------------------------------------ ERK7_Smoe ------------------------------------------------------------ ERK5_a-1_Smoe ------------------------------------------------------------ ERK5_c_Smoe ------------------------------------------------------------ ERK-p2-1_Smoe ------------------------------------------------------------ ERK-p1_a-1_Smoe ------------------------------------------------------------ ERK-p1_b-2_Smoe ------------------------------------------------------------ GK037_Glam ------------------------------------------------------------ rl_Dmel ------------------------------------------------------------ ERK2_Mmus ------------------------------------------------------------ ERK1_Mmus ------------------------------------------------------------ mpk-1_Cele ------------------------------------------------------------ SMK1_Scer ------------------------------------------------------------ SLT2_Scer ------------------------------------------------------------ KSS1_Scer ------------------------------------------------------------ FUS3_Scer ------------------------------------------------------------ Erk2_Hsap ------------------------------------------------------------ Erk1_Hsap ------------------------------------------------------------ YKL161C_Scer ------------------------------------------------------------ ERK1_Spur ------------------------------------------------------------ CC1G_02007_Ccin ------------------------------------------------------------ AqueK118_Aque ------------------------------------------------------------ AqueK119_Aque GCVFGEMLLGQPLFVSDANAVNLFRVLFSTLGRPKDQELAFVTSRLGLQVLKELKLNESP AqueK120_Aque GCVFGEMLLGQPLFVSDANAVNIFRVIFSTLGRPKDQELAFVTSRIGLQVLKELKINESP ERK-p2-2_Smoe ------------------------------------------------------------ ERK-Un_Smoe ------------------------------------------------------------ ERK5_b_Smoe ------------------------------------------------------------ ERK-p1_a-2_Smoe ------------------------------------------------------------ ERK5_a-2_Smoe ------------------------------------------------------------ ERK-p1_b-1_Smoe ------------------------------------------------------------ ERK7_Smoe ------------------------------------------------------------ ERK5_a-1_Smoe ------------------------------------------------------------ ERK5_c_Smoe ------------------------------------------------------------ ERK-p2-1_Smoe ------------------------------------------------------------ ERK-p1_a-1_Smoe ------------------------------------------------------------ ERK-p1_b-2_Smoe ------------------------------------------------------------ GK037_Glam ------------------------------------------------------------ rl_Dmel ---------------------------------------------------------FRI ERK2_Mmus ---------------------------------------------------------FKF ERK1_Mmus ---------------------------------------------------------FTF mpk-1_Cele ---------------------------------------------------------FTL SMK1_Scer ---------------------------------------------------------FDF SLT2_Scer ---------------------------------------------------------FEF KSS1_Scer ---------------------------------------------------------LDD FUS3_Scer ---------------------------------------------------------FEF Erk2_Hsap ---------------------------------------------------------FKF Erk1_Hsap ---------------------------------------------------------FTF YKL161C_Scer ---------------------------------------------------------FRF ERK1_Spur ---------------------------------------------------------FNF CC1G_02007_Ccin ---------------------------------------------------------FDF AqueK118_Aque ---------------------------------------------------------FKF AqueK119_Aque SLDSNLRKRNVDGQVLDLLKKMLAFSPAKRLTAEEALKHPYFAKLHDPAEEPVYTGKMSS AqueK120_Aque SLDSNLRKRNVDGQVIDLLKKMLAFSPAKRITAEEALKHPYFAKLHDPAEEPVYTGKMSS ERK-p2-2_Smoe ---------------------------------------------------------FDF ERK-Un_Smoe ---------------------------------------------------------FAF ERK5_b_Smoe ---------------------------------------------------------MEF ERK-p1_a-2_Smoe ---------------------------------------------------------PDV ERK5_a-2_Smoe ---------------------------------------------------------MEF ERK-p1_b-1_Smoe ---------------------------------------------------------FEF ERK7_Smoe ---------------------------------------------------------IRI ERK5_a-1_Smoe ---------------------------------------------------------MEF ERK5_c_Smoe ---------------------------------------------------------MEF ERK-p2-1_Smoe ---------------------------------------------------------FDF ERK-p1_a-1_Smoe ---------------------------------------------------------PDV ERK-p1_b-2_Smoe ---------------------------------------------------------FEF GK037_Glam ---------------------------------------------------------LEL rl_Dmel NM-----------EN-DDISRDALKSLIFEETL---------------KFKERQ------ ERK2_Mmus DM-----------EL-DDLPKEKLKELIFEETA---------------RFQPG------- ERK1_Mmus DM-----------EL-DDLPKERLKELIFQETA---------------RFQPGA------ mpk-1_Cele EM-----------EF-DDLPKEKLKELIWEEAE---------------AHHRRMEAE--- SMK1_Scer TY-----------ES-ELNSMSKLRDYLVEEVK---------------NFKTDL------ SLT2_Scer SF-----------ES-VN-DMEDLKQMVIQEVQ---------------DFRLFVRQPLL- KSS1_Scer EFWKLDNKIMRPEEE-EEVPIEMLKDMLYDELM--------------------------- FUS3_Scer DH-----------YK-EALTTKDLKKLIWNEIF--------------------------- Erk2_Hsap DM-----------EL-DDLPKEKLKELIFEETA---------------RFQPG------- Erk1_Hsap AM-----------EL-DDLPKERLKELIFQETA---------------RFQPGV------ YKL161C_Scer EF-----------EH-IE-SMAELGNEVIKEVF---------------DFRKVVRKHPI- ERK1_Spur SM-----------TH-VDIPKSYLKELLFQKFT---------------I----------- CC1G_02007_Ccin SF-----------EE-ED-SIEGMKRLIVEEVN---------------NFRAEVRAQAR- AqueK118_Aque EM-----------EL-DDLPKDRLKQLIYEETM---------------NFHP-------- AqueK119_Aque EV-----------VT-DDLPTSQLRAKLLEEVH---------------L----------- AqueK120_Aque EV-----------VT-DDLPTSQLRAKILEEVH---------------L----------- ERK-p2-2_Smoe DF-----------EQ-PTFSEDNIKELIYEESL---------------TFTTADM----- ERK-Un_Smoe S----------------------------------------------------------- ERK5_b_Smoe EF-----------ER-RRLTREDVRELIYREVTHDCRFESLSTASQILEYHPQMKME--- ERK-p1_a-2_Smoe ME-----------DQ-MVDTSSNLREYVWREMC---------------YYHPQAI----- ERK5_a-2_Smoe EF-----------ER-RRISKDDVRELIYREIL---------------EYHPQMLEE--- ERK-p1_b-1_Smoe DF-----------ED-EELREDALREKVWNEMC---------------YYHPEATN---- ERK7_Smoe PI-----------DDNHKFTIHEYRERLYAEII---------------SRKKEIRKKARE ERK5_a-1_Smoe EF-----------ER-RRISKDDVRELIYREIL---------------EYHPQMLEE--- ERK5_c_Smoe EF-----------ER-RRLTREDVRELIYREIL---------------EYHPQMKME--- ERK-p2-1_Smoe DF-----------EQ-PTFSEDNIKELIYEESL---------------TFTTADM----- ERK-p1_a-1_Smoe ME-----------DQ-MVDTSSNLREYVWREMC---------------YYHPQAI----- ERK-p1_b-2_Smoe DF-----------ED-EELREDALREKVWNEMC---------------YYHPEATN---- GK037_Glam FF-----------EK-YELTKPLLEMCFLNEAR---------------KFHPDELKD--- rl_Dmel ------------------------------------------------------------ ERK2_Mmus ------------------------------------------------------------ ERK1_Mmus ------------------------------------------------------------ mpk-1_Cele -------AAA-------------------------------------------------- SMK1_Scer ------------------------------------------------------------ SLT2_Scer ---------EEQRQLQLQQQQQQQQQQQQQQQQPSDVDNGN--AAASEENYPKQMATSNS KSS1_Scer ------------------------------------------------------------ FUS3_Scer ------------------------------------------------------------ Erk2_Hsap ------------------------------------------------------------ Erk1_Hsap ------------------------------------------------------------ YKL161C_Scer --------SGDSPSSSLSLEDA----------IP-------QEVVQV--H-PSR--KV-- ERK1_Spur ------------------------------------------------------------ CC1G_02007_Ccin ---------GSA-QNH------RSTKDSDNLGIPSRDEIISSPVKEFGPH-PGH--TSN- AqueK118_Aque ------------------------------------------------------------ AqueK119_Aque ------------------------------------------------------------ AqueK120_Aque ------------------------------------------------------------ ERK-p2-2_Smoe ------------------------------------------------------------ ERK-Un_Smoe ------------------------------------------------------------ ERK5_b_Smoe -------YV--------------NGNDQANFMYPSAVDQFRRQFAHLEEHYAKG----NA ERK-p1_a-2_Smoe ------------------------------------------------------------ ERK5_a-2_Smoe -------YL--------------NGTDHANFMYPSAVDQFKRQFAQLEEHYGKGG---HN ERK-p1_b-1_Smoe ------------------------------------------------------------ ERK7_Smoe RERSLHREM--------------SRMQ--------------------------------- ERK5_a-1_Smoe -------YL--------------NGTDHANFMYPSAVDQFKRQFAQLEEHYGKGG---NN ERK5_c_Smoe -------YV--------------NGNDQANFMYPSAVDQFRRQFAHLEEHYAKG----NA ERK-p2-1_Smoe ------------------------------------------------------------ ERK-p1_a-1_Smoe ------------------------------------------------------------ ERK-p1_b-2_Smoe ------------------------------------------------------------ GK037_Glam -------EV--------------AKRA--------------------------------- rl_Dmel ------------------------------------------------------------ ERK2_Mmus ------------------------------------------------------------ ERK1_Mmus ------------------------------------------------------------ mpk-1_Cele ------------------------------------------------------------ SMK1_Scer ------------------------------------------------------------ SLT2_Scer VAPQQESFGIHSQNLPRHDADFPPRPQES------------------------------- KSS1_Scer ------------------------------------------------------------ FUS3_Scer ------------------------------------------------------------ Erk2_Hsap ------------------------------------------------------------ Erk1_Hsap ------------------------------------------------------------ YKL161C_Scer --------------LPSY----SP------------------------------------ ERK1_Spur ------------------------------------------------------------ CC1G_02007_Ccin ----------YTTNA--------P------------------------------------ AqueK118_Aque ------------------------------------------------------------ AqueK119_Aque ------------------------------------------------------------ AqueK120_Aque ------------------------------------------------------------ ERK-p2-2_Smoe ------------------------------------------------------------ ERK-Un_Smoe ------------------------------------------------------------ ERK5_b_Smoe MVPLE----RQHASLPRLVV--------SFS--------CCIDNRGKCSSAGTTILAVPC ERK-p1_a-2_Smoe ------------------------------------------------------------ ERK5_a-2_Smoe NAAVE----RHHASLPRFEA--------FLFIVNVILKRINITGRRRCT---------PA ERK-p1_b-1_Smoe ------------------------------------------------------------ ERK7_Smoe ------------------------------------------------------------ ERK5_a-1_Smoe NAAVE----RHHASLPRFEA--------FLFIVNVILKRINITGRRRCT---------PA ERK5_c_Smoe MVPLE----RQHASLPR------------------------------------------- ERK-p2-1_Smoe ------------------------------------------------------------ ERK-p1_a-1_Smoe ------------------------------------------------------------ ERK-p1_b-2_Smoe ------------------------------------------------------------ GK037_Glam ------------------------------------------------------------ rl_Dmel ------------------------------------------PDNAP ERK2_Mmus --------------------------------------------YRS ERK1_Mmus -------------------------------------------PEGP mpk-1_Cele -------------------------------------R-NNGGQNPV SMK1_Scer ------------------------------------------SSSSL SLT2_Scer --MME----MR-PATGNTADIPPQN-DNGTLLDLEKELEFGLDRKYF KSS1_Scer -------------------------------------------KTME FUS3_Scer ----------------------------------------------S Erk2_Hsap --------------------------------------------YRS Erk1_Hsap -------------------------------------------LEAP YKL161C_Scer -------------EFSYVSQLPSLT-TTQPYQNLMGIS-SNSFQGVN ERK1_Spur ----------------------------------------------F CC1G_02007_Ccin -------------------RAPSPI-MDDPSAELEREL-ASTHISKK AqueK118_Aque --------------------------------------------HAV AqueK119_Aque -----------------------------------------F-SSPQ AqueK120_Aque -----------------------------------------F-SSPQ ERK-p2-2_Smoe --------------------------------------------VTE ERK-Un_Smoe ------------------------------------------YKYSM ERK5_b_Smoe WLFLSMCY-LREQA--CRSSEESPVPIVSLFYLF--LH-ITHLFYSC ERK-p1_a-2_Smoe --------------------------------------------NEM ERK5_a-2_Smoe LLLLQVTVLARNEN--TTTRGSSRR-SLSRRSRLE-RH-RKVVTKAS ERK-p1_b-1_Smoe --------------------------------------------EYS ERK7_Smoe --------------------------------S---RR-SSYHPRAS ERK5_a-1_Smoe LLLLQVTVPARNEN--TTTRGSSRR-SLSRRSRLE-RH-RKVVTKAS ERK5_c_Smoe ----------------------------------------LVVSFSC ERK-p2-1_Smoe --------------------------------------------VTE ERK-p1_a-1_Smoe --------------------------------------------NEM ERK-p1_b-2_Smoe --------------------------------------------EYS GK037_Glam --------------------------------K---AL-GIPESVWM