CLUSTAL W (1.83) multiple sequence alignment Erk5_Hsap MAEPL-KEEDG------------------------EDGSAEPPGPVKAEPAHTAASVAAK ERK5_Mmus MAEPL-KEEDG------------------------EDGSGEPPGRVKAEPVHTAASVVAK ERK5_Spur MQ-----------------------------------------------------QAASR AqueK121_Aque MEVHQIQTEKKPQETQKPQNSQTLDNQRLGVEEKSIPGTSEMILVRSSNSPKPSTGTSDK * . : Erk5_Hsap NLALLKARSFDVTFDVG-DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVT ERK5_Mmus NLALLKARSFDVTFDVG-DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVT ERK5_Spur SLLAFKGRCMDVKFDIANSNYKPLEKIGTGAYGVVCSAINKKNGEKVAIKKIPNSFDELT AqueK121_Aque RVYTIKHRSMSVKFECD-SRYTPLESIGTGAYGVVCAAKDNRTGRKVAIKKIPRAFDEVV : :* *.:.*.*: ..* :*.**.******.:* . .*.:*******.:** :. Erk5_Hsap NAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPL ERK5_Mmus NAKRTLRELKILKHFKHDNIIAIKDILKPTVPYGEFRSVYVVLDLMESDLHQIIHSSQPL ERK5_Spur TAKRTFRELKILRHFRHENVIAIREILMPKEPLSEMKDVYVVFDLMESDLHQIIHSNQPF AqueK121_Aque TAKRTYRELKILRHLRHENVISILDVMEPPENESSLQDVYVILDLMETDLHHIIHSVQPL .**** ******:*::*:*:*:* ::: * ..::.***::****:***:**** **: Erk5_Hsap TLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPA-E ERK5_Mmus TLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPA-E ERK5_Spur SLEHIRFFLYQILRGLKYIHSADVIHRDLKPSNLLVNENCELKVGDFGMARGLSTFSTDK AqueK121_Aque SDDHIKYFLYQIGRGLKYIHSANIIHRDLKPSNLLINRNCELKIGDFGMARGLSSTPE-D : :*:::****: *****:***::***********:*.*****:*********.: . . Erk5_Hsap HQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQL ERK5_Mmus HQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQL ERK5_Spur KKMFMTSYVATRWYRAPELLFSSDDYTLAVDVWSVGCILGEMIGRKQMFPGKNPIDQLSL AqueK121_Aque HALFLTEYVATRWYRAPELMLSFSQYDISLDMWSVGCIFAEMLGRRQIFPGKNYVNQLQL : *:*.************::* :* ::*:******:.**:.*:*:***** :.**.* Erk5_Hsap IMMVLGTPSPAVIQAVGAERVRAYIQ-SLPPRQPVPWETVYPGADRQALSLLGRMLRFEP ERK5_Mmus IMMVLGTPSPAVIQAVGAERVRAYIQ-SLPPRQPVPWETVYPGADRQALSLLGRMLRFEP ERK5_Spur IVDVLGMPPTHMLKSTSSDHLYNFFQKNFANKTPKDLSKLYPKADPQGLDLLAKMLIFEP AqueK121_Aque VLSVVGTPSDEYINNIGSERVKTYLK-SLPKKQPVDLFVLFPKANKVALELLEKLLQLDP :: *:* *. :: .:::: ::: .:. : * ::* *: .*.** ::* ::* Erk5_Hsap SARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARR ERK5_Mmus SARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARR ERK5_Spur SERITVNKALQHPFLATYYSPDDEPDCFPKFDFSFESHVMSREQIKQQIGKMILKYNKPT AqueK121_Aque RKRYIAIEILGHPYLSLYHDITDEPICTPPFDFTFEKTLDTKELLRSAVVDELKEYHKCR * . * **:*: *:. *** * * ***:*: ::* ::. : : .:: Erk5_Hsap EGIRQQIRFQPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPAPPPCPG-PA-PDTID ERK5_Mmus EGIRQQIRFQPSLQPVASEPVCPDVEMPSPWAPSGDCAMESPPPALPPCSD-PA-PDTVD ERK5_Spur GWV-SKGLLRPSSRRTTLETVGPSFN-KDPQGAGGEVRNDSDGDSVPPSSSSPLIRESLL AqueK121_Aque IPI-------------------------------------------PPTNQV---RDALK : ** ::: Erk5_Hsap LTLQPPP----PVSEPA-PPKKDGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAPEPR ERK5_Mmus LTLQPAP----PASELA-PPKREGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAPEPR ERK5_Spur SGLSQTSPLFGGLTDLS-PNSSQKTISEDTKALIKAALMN---SALKNHKKDRLGKGGGK AqueK121_Aque KMMEEREQK---SSEGGEPEKRE-------QKEVAAVKKKRLDERKRRTPDHQIHGPE-- :. :: . * . : : : *. : . : . : Erk5_Hsap KPVTAQERQREREEKRRRRQERA-KEREKRRQERERKERGAGASGGPSTDPLAGLVLSDN ERK5_Mmus KPVTAQERQREREEKRRRRQERA-KEREKRRQERERKERGAGTLGGPSTDPLAGLVLSDN ERK5_Spur MPVTALSRQREREEKRKQKIRRSMKKKKKNRHDKEEKKQ-------------PPALLTEE AqueK121_Aque ---------------------------K------PKKKQ------------KVYSPLTDS : .*:: *::. Erk5_Hsap DRSLLERWTRMARPAAPALTS--------------------------------V------ ERK5_Mmus DRSLLERWTRMARPPAPA------------------------------------------ ERK5_Spur DKNMLERWNRMQQKNAAAAKS--------------------------------QDESSRR AqueK121_Aque DRTALEHWNKLAVAVSNTTKKKGQETEEILSLQQQQELLIKQQAEQLEKQQKQMVEQQRR *:. **:*.:: : : Erk5_Hsap -----P------------------------------------------------------ ERK5_Mmus -----P------------------------------------------------------ ERK5_Spur VKSESD------------------------------------------------------ AqueK121_Aque IQQQSEQIRQLVHHQKVLIRECKAAGIKIPLSTPNPSPLSQAGLVSSPLTNASITTVKLT Erk5_Hsap -----APAPAPTPTPTPVQPTSPP------------PGPVAQPTGPQPQSAGSTSGPV-- ERK5_Mmus -----APAPAPAPAPSSAQPTSTP------------TGPVSQSTGPL-QPAGSIPGPA-- ERK5_Spur -----APYEPAAKTQLPNDPKRSDV---DVVQYSTKFDPADTSSGNV------------- AqueK121_Aque PPVQAHPLPIVKPHPFPVQPHPPPFDPGSLIRTDVPVSPVNNSTTSN-SQSSSVPPATAT * . :* . .*. .: Erk5_Hsap -------------PQPACPPPGPAPHPTGPPGPIPVPAPPQI---ATSTSLLAAQSLVPP ERK5_Mmus -------------SQPVCPPPGPVPQPAGP-----IPAPLQT---APSTSLLASQSLVPP ERK5_Spur -------------LKGLRVSATLMESPKST-----TSQANPAGSLNNHTSTTANRSQ--- AqueK121_Aque HAINYQNQPPVVAPPPTVAPPTAIAPPTSS-----ITYPLPV---PSYSTMLPTDSY-PP .. * .. . . :: . * Erk5_Hsap PG----LPGSSTP-------GVLPYFPPGLP--------PPDAGGAPQSSMSESPDVNLV ERK5_Mmus SG----LPGSGAP-------EVLPYFPSGPP--------PPDPGLTPQPSTSESPDVNLV ERK5_Spur -NPALV-----------------------------------------RRHDSTSSDITNI AqueK121_Aque HGPPLPLPQS-PPDFMSSYIPVLPAQPSVPPDRSVPYCGPPAEF---FSPLTSKELVELT . : . : Erk5_Hsap TQQLSKS-------------QVEDPLPPVFS----GTPKGS-GAGYGVGFDLEEFLNQSF ERK5_Mmus TQQLSKS-------------QVEDPLPPVFS----GTPKGS-GAGYGVGFDLEEFLNQSF ERK5_Spur IRQLSRS-------------VVEDTLPSLLSVPLPVTPKGD-GGGYGLSLDIEELMGESL AqueK121_Aque SQEMRKLSPYIPQSIDSFVPPLQEDLEKMFN----VPPGGTFGGGYGVGISDDELTIMVP ::: : ::: * ::. .* * *.***:.:. :*: Erk5_Hsap DMGVADGPQDGQADSASLSASLLADWLEG-HGMNPADIESL---QREIQMDSPMLLADLP ERK5_Mmus DMGVADGPQDGQADSASLSASLLADWLEG-HGMNPADIESL---QREIQMDSPMLLSDLP ERK5_Spur DPNVQI---NDRCDSAPLSASLLSDWLDV-RNLNSEDIENLRDIQRELGLTSPVGIPVVP AqueK121_Aque DNKIE----------GPPSASLLQEWLQDIDDIDSQGLQAL---QQEMEFGASEMF--FR * : .. ***** :**: .::. .:: * *:*: : :. : . Erk5_Hsap DL--------QDP ERK5_Mmus DL--------QEP ERK5_Spur PLGAAQSNRNPKL AqueK121_Aque EL--------EKL * .