CLUSTAL W (1.83) multiple sequence alignment Fused_Hsap ME-KYHV---LEM----------------------------------------------- 1647_Tthe ME-NYHI---LHQ----------------------------------------------- Fused_Spur MK-EMHHPNIIEMLDTFETDKEVVAVTDYAEGELFQILEDDGTLPEEQVKEIACQLLSAL Fused_Mmus ME-KYHV---LEM----------------------------------------------- tsunami_Ddis MDDDYKL---IGQ----------------------------------------------- fu_Dmel MN-RYAV---SSM----------------------------------------------- AqueK209_Aque ME-QYHV---MEL----------------------------------------------- GK069_Glam MH-RYEQ---IAQ----------------------------------------------- *. Fused_Hsap -------------------IGEGS------------------------------------ 1647_Tthe -------------------IGEGS------------------------------------ Fused_Spur YYLHAHRILHRDMKPQNILLGKGGVVKLCDFGFARAMSINTLVLTSIKGTPLYMAPELVE Fused_Mmus -------------------IGEGS------------------------------------ tsunami_Ddis -------------------IGEGS------------------------------------ fu_Dmel -------------------VGQGS------------------------------------ AqueK209_Aque -------------------IGEGS------------------------------------ GK069_Glam -------------------IGKGS------------------------------------ :*:*. Fused_Hsap ------------FGRV-----------------------------YKGRRKYSAQVVALK 1647_Tthe ------------FGKV-----------------------------FKGRRKNTGQILALK Fused_Spur EKPYDHTADLWSLGCILYELFVGTPPFYTNSIFQLVSLIIKDPVKWPKNMEPEFKIVALK Fused_Mmus ------------FGRV-----------------------------YKGRKKYSAQVVALK tsunami_Ddis ------------FGKV-----------------------------YKYRKKFTGQLVACK fu_Dmel ------------FGCV-----------------------------YKATRKDDSKVVAIK AqueK209_Aque ------------FGRV-----------------------------YKGRIKHSKKVVALK GK069_Glam ------------FGVV-----------------------------YKCRLKQTGQFVAVK :* : : : :.:* * Fused_Hsap FIPKLGRSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILED 1647_Tthe FISK------------------RRLKHENIILLLDAFETPHEFCVVTEFAQGELFEILED Fused_Spur FIPKLGRSDKELDSLRKEIEIMKEMHHPNIIEMLDTFETDKEVVAVTDYAEGELFQILED Fused_Mmus FIPKLGRSEKELRNLQREIEIMRGLWHPNIVHMLDSFETDKEVVVVTDYAEGELFQILED tsunami_Ddis VISKKGKNEEDILSLRQEIDILKNLSHPNIIQFISCFENKNEFTLVTEYADGDLSQIISE fu_Dmel VISKRGRATKELKNLRRECDIQARLKHPHVIEMIESFESKTDLFVVTEFALMDLHRYLSY AqueK209_Aque FIPKVGRSEIELTNLRREISIMAELSHPNIIELYDCFETPDEVCMVTEFGEGDLFQILED GK069_Glam QISTYGKSSSELAALNSEISLLKEINHPNTIRFFESFEEDGSVVIVTELAQSDLHSIFAS *.. : * : : : . ** .. **: . :* : Fused_Hsap DGKLPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTN 1647_Tthe DRSLPESEVRKIAQQLILALDYLHSNRIIHRDMKPQNILISANGVVKLCDFGFARALSSN Fused_Spur DGTLPEEQVKEIACQLLSALYYLHAHRILHRDMKPQNILLGKGGVVKLCDFGFARAMSIN Fused_Mmus DGKLPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTN tsunami_Ddis EKTLSVDLIQSICYQLVIALNYLHYKKVIHRDIKPQNILITSGGQIKVCDFGFAKTISSN fu_Dmel NGAMGEEPARRVTGHLVSALYYLHSNRILHRDLKPQNVLLDKNMHAKLCDFGLARNMTLG AqueK209_Aque DTTLPESEIQVIAVQLVSALFYLHSRRILHRDMKPQNILIGKGRQTKLCDFGFARAMSFQ GK069_Glam DGPLNIETIQKVCFQLLNVLTYLHSRRIAHRDIKSQNVLISQG-VCKLCDFGFARQMSQQ : : . : : :*: .* *** .:: ***:*.**:*: . *:****:*: :: Fused_Hsap TMVLTSIKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLIL 1647_Tthe TQVLTSIKGTPLYMAPELVKEQPYNHTVDLWSLGVILYELFVGQPPFYTNSIYKLIDLII Fused_Spur TLVLTSIKGTPLYMAPELVEEKPYDHTADLWSLGCILYELFVGTPPFYTNSIFQLVSLII Fused_Mmus TMVLTSIKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLIL tsunami_Ddis SILLTSLKGTPLYLAPEIIQEQPYDYKADLWSLGIILYQILVGSPPFSANSLADLVHMTL fu_Dmel THVLTSIKGTPLYMAPELLAEQPYDHHADMWSLGCIAYESMAGQPPFCASSILHLVKMIK AqueK209_Aque TLVLTSIKGTPLYMCPELVQEKPYDHNSDLWALGCILYELFVGEPPFYTNNIVQLVKMIT GK069_Glam TLALQSIKGTPLYLAPEIAKGKKYNTISDMWAFGVMIFELATGRTPFTATDFLTLMSILQ : * *:******:.**: : *: *:*:.* : :: .* .** :..: *: : Fused_Hsap KDPVRWPSTIS------PCFKNFLQGLLTKDPRQRLSWPDLLYHPFIAGHVTI------- 1647_Tthe KDPVKYPDNMS------QEFKDFLMGLLNKNPSERADWPNLLNHPFIQETEPEK------ Fused_Spur --------------------KDFLQGLLTKSAKHRLTWPALLYHPFVDGGVKV------- Fused_Mmus KDPVRWPSTIS------SCFKNFLQGLLTKDPRQRLSWPDLLHHPFIAGRVTI------- tsunami_Ddis ESNIEIPKELN----KYPDLVSLFRQLLCKNPDKRIGWPDLLYHPFVKSYNGAHVINNNN fu_Dmel HEDVKWPSTL------TSECRSFLQGLLEKDPGLRISWTQLLCHPFVEGRIFI------- AqueK209_Aque NDDVFFPDTMS------NVFNNFLKGLLEKDSSKRLSWPDLLYHPFVMEGLDH------- GK069_Glam DDSNKVPYDKYPIFAREPLFKSFCECMLQRNPDKRWASKQMLDHPFLNEGSAIRL----- .: :* :.. * :* ***: Fused_Hsap --------------------------------ITEPAGPDLGTP---------------- 1647_Tthe ------------------------------------------------------------ Fused_Spur --------------------------------SDSL----TEHP---------------- Fused_Mmus --------------------------------ITEPAGSDLGTP---------------- tsunami_Ddis LNYNNNNNNNNNNNNNNNNGNRPITSAGGNYLNDNSSSPSISSPI--------------- fu_Dmel --------------------------------AETQAEAAKESPFTNPEAKVKSS--KQS AqueK209_Aque ------------------------------------------------------------ GK069_Glam --------------------------------AKHVNDAYK---FKDWLALLRTMKQQSA Fused_Hsap ------------------------------------------------------------ 1647_Tthe ------------------------------------------------------------ Fused_Spur ------------------------------------------------------------ Fused_Mmus ------------------------------------------------------------ tsunami_Ddis ----------------------QSLPLISADSLINSLNNNINNNNNNNNNNNNNNNNNNN fu_Dmel DP------------------------------------------EVGDLDEA----LAAL AqueK209_Aque ------------------------------------------------------------ GK069_Glam LQSILLTVNTEAVVEVVEQGALTEEYADNFYDNRLIDAINEAINSAHDLPPIVIALMALL Fused_Hsap ------------------------------------------------------------ 1647_Tthe ------------------------------------------------------------ Fused_Spur ------------------------------------------------------------ Fused_Mmus ------------------------------------------------------------ tsunami_Ddis NNNNNNNNNNNNNNNNNNNNNNNNGNINTNGYYQPLQSPTSQ------------------ fu_Dmel DFGESRQENLTTSRDSINAIAPSDVEHLETD----------------------------- AqueK209_Aque ------------------------------------------------------------ GK069_Glam SINSNQAEAIFTSEVVSSHIHNADSRNLEKDYYRILAYIHSHPGDKEEAFYRVADFMAFL Fused_Hsap ------------------------------------------------------------ 1647_Tthe ------------------------------------------------------------ Fused_Spur ------------------------------------------------------------ Fused_Mmus ------------------------------------------------------------ tsunami_Ddis ---------------------------------------------NFVNGIPIPILNGIS fu_Dmel ------------------------------------------------------------ AqueK209_Aque ------------------------------------------------------------ GK069_Glam IVRSSSTFLQLIQSALRCISKTNLAQTDVISIVLLLRVSAVCFGCMFTWNVPISFGQIVS Fused_Hsap --FT-----------------SRLPPELQVLKDEQAHR---------------------- 1647_Tthe --------------------------------AERRKRLEKY------------------ Fused_Spur --FT-----------------QA-PSAEEVARKEKAVQE--------------------- Fused_Mmus --FT-----------------SRLPPELQVLKDEQAHR---------------------- tsunami_Ddis NPFSVYNNNNNMNNNNNNKFNPTSPKHHQTLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ fu_Dmel ------------------------------------------------------------ AqueK209_Aque ---------------------------------EYLAQCAKE------------------ GK069_Glam FPYDMYIKAEDVVFPSKAEDKP-------VL--------TRRAHIVAAA-INTLSATSTI Fused_Hsap --------------------LAPKGN-------------------QSRILTQAYKRMAEE 1647_Tthe ------------------------------------------------------------ Fused_Spur --------KSSN--------VAPG----------------------TTIMR--------- Fused_Mmus --------------------LAPKGN-------------------QSRILRQACKLMAEE tsunami_Ddis QQQQQQQQIPPPQSPKTPKVLSPKAV-------------------GISIQQQQQQQSQQQ fu_Dmel --------------------------------VEDNM----------------------- AqueK209_Aque ------------------------------------------------------------ GK069_Glam EKL---------FESFNTI--ISKSIGVIETSTESFIIKCLLYCINVSFCMGTTAQSSVQ Fused_Hsap -AMQ-----------------------KKHQ--NTG-PALEQEDK--------------- 1647_Tthe -------------------------------QQWAGLQEVNGSDE--------------- Fused_Spur --KL-----------------------KQRE--QGP-PAEEQKDG--------------- Fused_Mmus -AKQ-----------------------KEDQ--NAG-SALEQEDG--------------- tsunami_Ddis -QMQ-----------------------QQQQQQQQQ-QQQQQQQQ--------------- fu_Dmel ----------------------------QRV--VVP------------------------ AqueK209_Aque ---------------------------------------G---HI--------------- GK069_Glam FLMQEYVLYLPSGNRMIGLEHLLTDDYADAD--MGS-GGDEVKKGSGNDGFKLRTIDVRY Fused_Hsap ------------------------------------------------------------ 1647_Tthe ------------------------------------------------------------ Fused_Spur ------------------------------------------------------------ Fused_Mmus ------------------------------------------------------------ tsunami_Ddis ------------------------------------------------------------ fu_Dmel --------FADLSYRDLSGVRAMPMVHQPVIN---------------------------- AqueK209_Aque ------------------------------------------------------------ GK069_Glam DVNIRNSLFGQIDTRDYNKFRFLPEYFKKFTSSEKATVISTDLFGEDEYSYVGIFLSENF Fused_Hsap ------------------------------------------------------------ 1647_Tthe ------------------------------------------------------------ Fused_Spur ------------------------------------------------------------ Fused_Mmus ------------------------------------------------------------ tsunami_Ddis ------------------------------------------------------------ fu_Dmel ------------------------------------------------------------ AqueK209_Aque ------------------------------------------------------------ GK069_Glam KAYINRFVDLISGRCSRDYPILLTRLYVIFKRLINFKNGIKLDEGYITIYNNYTTTCLQT Fused_Hsap -------TSKVAPGT------------APLPRLGATPQESSLLAG-ILASELKSSWAKSG 1647_Tthe -------KEN------------------AVPSVQSIPNQQAPLTPGLNGQKRK------- Fused_Spur -------AGG-DGKK------------PHKPS------GEKAKAKPRIAKS----EPWPS Fused_Mmus -------LCKVTPST------------APVPGLKATPQESSLLAG-ILASEMKNNWEDWG tsunami_Ddis -------IPPQSPKV------------PQSPRVAPPPQSPRVLSSPRIAHSPKNSPRQTN fu_Dmel ------------------------------------------------------------ AqueK209_Aque -------TAS------------------SRPSSTSLPSEQETFTPILDK----------- GK069_Glam LFQAADAVSQTDPNNAMQAAIATIIKNLNLPILSADSSSSGVLKY-TMPS-LGQTIGKTA Fused_Hsap TGE--------VPSAPRENRTTPD------------CERAFPE---E------------- 1647_Tthe GSS--------TPTAQQQNNTNIL------------AFDGVGE---K------------- Fused_Spur VKE--------QEPTPRENRITHD------------YKQEFPS---V------------- Fused_Mmus AGE--------APRTSRENHINLE------------CEQGFPE---P------------- tsunami_Ddis PTS--------PSPSPRRNSLKSQQTPSLTNLNQALVNPSSSSSSLNSSIPTSSSTNKQI fu_Dmel ------------------------------------------------------------ AqueK209_Aque ------------------------------------------------------------ GK069_Glam VGDVLSGQTKINPSTPREGKGASG------------------------------------ Fused_Hsap ------------------------------------------------------------ 1647_Tthe ------------------------------------------------------------ Fused_Spur ------------------------------------------------------------ Fused_Mmus ------------------------------------------------------------ tsunami_Ddis PPLSSNLNQVNLSNNINDNNNIINNNSNNNSNNINNNINNNNNNNSNNINNNINNNINNI fu_Dmel ------------------------------------------------------------ AqueK209_Aque ------------------------------------------------------------ GK069_Glam ------------------------------------------------------------ Fused_Hsap ------------------------------------------------------------ 1647_Tthe ------------------------------------------------------------ Fused_Spur ------------------------------------------------------------ Fused_Mmus ------------------------------------------------------------ tsunami_Ddis NNNNNNNSNINNINNINNNNNINSSNNNSSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN fu_Dmel ------------------------------------------------------------ AqueK209_Aque ------------------------------------------------------------ GK069_Glam -----------------------------------------------------DGYAHGL Fused_Hsap --RPEV------------------------------------------------------ 1647_Tthe ------------------------------------------------------------ Fused_Spur --EVES------------------------------------------------------ Fused_Mmus --RPEA------------------------------------------------------ tsunami_Ddis NNNNNIINSSNNNINNINNSNNNINNSNN------------------------------- fu_Dmel ------------------------------------------------------------ AqueK209_Aque ------------------------------------------------------------ GK069_Glam RSNFDMLRAGSMTVSLAATSMAGMNQSINPHTLTPVSAIYPTVEFALILLHLRQTLLQNH Fused_Hsap ------------------------------------------------------------ 1647_Tthe --------------------------------------------------NK-------- Fused_Spur ------------------------------------------------------------ Fused_Mmus ------------------------------------------------------------ tsunami_Ddis -----------------------------------NININNSNNNINGNRPTSGGNNDLI fu_Dmel SHTCF--VSGNSNMILNHMNDNFDFQASLRGGGVAAKPI--------------------- AqueK209_Aque ------------------------------------------------------------ GK069_Glam QAIINMFTVRMPAKMLSTG-KLSALYAYYREPYCFNLEVSKGSNMAGITVETYHGSTAVE Fused_Hsap ----------------------------------------------------------L- 1647_Tthe ------------------------------------------------------------ Fused_Spur -------------------------------------------------------RRVLK Fused_Mmus ----------------------------------------------------------M- tsunami_Ddis LNNMLMNNISLSSSIESIASN-NNSILVQQQLQQQQQQIQ----------QQQQQIQLLQ fu_Dmel --------------------------VAPTVRQSR------------------------- AqueK209_Aque ------------------------------------------------------------ GK069_Glam LNNMVSGRSKTEMS---ILLNSENTFLIE-YLNTFKKQLAMCYCFLPFAYIQSDEKEVFR Fused_Hsap --------GQRSTDVVDLENEEPDSDNEWQHLLET------------------------- 1647_Tthe ------------------------------------------------------------ Fused_Spur KEGGKAKDMRKSIDNVSLQEEDVDSEDEWDSLCDI------------------------- Fused_Mmus --------GRQSTDVVDPENEEPDSDDEWQRLLET------------------------- tsunami_Ddis QQQQIQIQQQQQIQQQQQLQIQLMQQQQQLNIIQQQNSVVQNGMVVSVLNKKAPPTPITR fu_Dmel ------------------------------------------------------------ AqueK209_Aque ------------------------------------------------------------ GK069_Glam QLNSSREEFRRIVAEKEFVETQLSKKFHRGSVIEMQNKLQTDAETVDSIFTSFVRTVLAE Fused_Hsap -TEP-------------VPIQLKAPLT--------------------------------- 1647_Tthe -----------------VDNRDVSPRKVVCTDEIWSKY---------------------- Fused_Spur -TNP-------------DITDPRSIEA--------------------------------- Fused_Mmus -SEP-------------GPVQLKSPLT--------------------------------- tsunami_Ddis PQTP-------------TSFRPQTPQYRTCTPRTPQPINTPA--SRNNFQSNVLPSWPNL fu_Dmel -------SKDLEKRKLSQNL---------------------------------------- AqueK209_Aque ---------------------------PVCISSAWTNG---------------------- GK069_Glam IQSLKLNSFRFLKHIFAPSFQYLFPLY-TYSRKDPSPLAHHALYLKRRFQQSGIPNGDDI Fused_Hsap ------------------------------------------------------------ 1647_Tthe ------------------------------------------------------------ Fused_Spur ------------------------------------------------------------ Fused_Mmus ------------------------------------------------------------ tsunami_Ddis YYQQLNVNDPHQLQQLQQQQQQLQLQQQQQQQQQQQLPLSSSQQQIHYYNQMNHNGNSQN fu_Dmel ------------------------------------------------------------ AqueK209_Aque ------------------------------------------------------------ GK069_Glam NLNDIRDNDI-------------------------------------------------- Fused_Hsap -----------------------------------LLCNPDFCQRIQSQLHEAGGQILKG 1647_Tthe ----------------------EQ-QAKDDNGIAELRKDTGFLDKLLQLLKINVNDVLRK Fused_Spur -----------------------------------LLQDKAFVERIASRLEETSKQTLEG Fused_Mmus -----------------------------------LLCNPDFCQRIQSQLRGTGEQILKG tsunami_Ddis ERLDEISEASESLESLEFWRFHESISFKSEENASKLRSDKQFLHKIISHLSASSFSMIER fu_Dmel ------------------------------------------------------------ AqueK209_Aque ----------------------ED-KDKTD------------------------------ GK069_Glam ------------------------------------------------------------ Fused_Hsap ILEGASHILPAFRVLSSLLS-SC----SDSVALYSFCRE-AGLPGLLLSLLRH------- 1647_Tthe --EKKSSVLIGLKVLCQVIIRGR----SDDDNKIDITKN-ALLPGLLINLLKN------- Fused_Spur MLEGASRLRLVLHVINNLLA-YK----GFADLLTDFCHM-TKVPMFPLDVLSK------- Fused_Mmus VLDGVSHLLPVLRILSSLLS-SC----NDSVLLYSFCQE-AGLPELPLSLLRY------- tsunami_Ddis --LPI---GLILRTFSNIMKYGTLTIQSSNNTTLQSTRTPPQTPPLYPSFNNNGNNSNNN fu_Dmel ------------------------------------------------------------ AqueK209_Aque ------------------------------------------------------------ GK069_Glam ------------------------------------------------------------ Fused_Hsap --------------SQESNSLQQQSWYGTFLQDLMAVIQAYFACTFNLERS--------- 1647_Tthe --------------I---LKIDQSKTLIDLICELIKTICLLAKSTFDKNVG--------- Fused_Spur --------------MKDNSTVKEQAWFVQILTDLVSVMAAYVMSDVAIELN--------- Fused_Mmus --------------SQESSSIQQQPWYGALLRDLVAVVQAYFSCTFNLERS--------- tsunami_Ddis NNSNNSGGGNNSSEI---YK-------FSNFQILVNVLSNILATTLHITNGNGNSGIIGS fu_Dmel ------------------------------------------------------------ AqueK209_Aque ------------------------------------------------------------ GK069_Glam ------------------------------------------------------------ Fused_Hsap ---------------------QTSDSLQVFQEAANLFLDLLG------------------ 1647_Tthe ---------------------IENTYIQVFLPQIPQLIKLG------------------- Fused_Spur ---------------------I--DRTKDVMEAALNFAGILP------------------ Fused_Mmus ---------------------QTGDSLQVFQEAASLFLDLLG------------------ tsunami_Ddis TSSNGMVLLNNPYTNLLDCLNTITMFLETFQPSLSVLFNVNGLNERHGSSSTPNQSSPCP fu_Dmel --------------------------------------DNFS------------------ AqueK209_Aque ---------------------TKRTEEDIV------------------------------ GK069_Glam --------------------------------------KTLV------------------ Fused_Hsap -------------------KLLAQPDDSEQTLRRDSLMCFTVLCEAMDGNSRA------- 1647_Tthe --------------------------SSNNDIPHQSLLINIVKTIGIFGNQ--------- Fused_Spur -------------------WLIHIKEDEDLNLRAQSVCCFIYQCEVMDRAHEE------- Fused_Mmus -------------------KLLAQSDDSEQTFRRDSLMCFAVLCEAVDGNSWA------- tsunami_Ddis TSPNGGSSNISINNINGGKRIHSQPQQSNQTQQINTQLMFLSILNHLTKNIFIYNQGIQI fu_Dmel -------------------VRLGHSVDHEAQRKATEI-----ATQEKHNQE--------- AqueK209_Aque ------------------------------------------------------------ GK069_Glam -------------------KLLIQADLP---RRGHFIITIPQVCYIFDGMS--------- Fused_Hsap -------------------I--SKAFYSSLL-----------------TTQQVVLDGL-- 1647_Tthe ------------ASANPI-R--NYNFYKELI-----------------EIKF-IPDSIAL Fused_Spur -------------------F--VTGYYAGLA-----------------TTHLPVVTAL-- Fused_Mmus -------------------V--SKAFYSSLL-----------------TTQRAVLDGL-- tsunami_Ddis AVIKIISRLFSRLGENPY-L--FGEIYRKII-----------------EQTD-ILQNICS fu_Dmel ------------NKPPAEAI--S------------------------------------- AqueK209_Aque -----------------------------------------------------LP----- GK069_Glam ------------LPGNPFSIQISSDPFSTFSLYQTNANLVSTYMILSECIRMVVEEAF-- Fused_Hsap LHGLTVPQLPVHTPQGAPQVSQPLREQSED----IP--GAISS----ALAAICT-AP--- 1647_Tthe LKSMENAQSL---HNFIIQVLAVLVHPVYGDIFTFPWKRGLSG----AVSEFCE-C---- Fused_Spur LKTLEQDEALVKKVTSGPE-GEAFGDRWEQ----MC--GVAIG----GLAELVY-LQ--- Fused_Mmus LHGLTVPQLPFHTPPGAPQVSQPLREQSED----VP--GAISS----ALAAMCT-AP--- tsunami_Ddis YFLLLLNQSYQSSSSSTISNTSSLSSSSTS----PP--TSSSS----STSSSTT-TP--- fu_Dmel -----------------YANSQPPQQQPQQ----LK--HSMHSTNEEKLSSDNT-PP--- AqueK209_Aque ------------------------------------------------------------ GK069_Glam LNGLLVL--TTENDVQMYQISNVVVQKYID----IH--VIFAT------STDGTIPPSDY Fused_Hsap --VGLPDCWDAKEQVCWHLA----------NQLTEDSSQ-LRPSLISGLQ-HPILCLH-- 1647_Tthe --LYIFECLKTQVYTCLQEVDWLSLFVRLYN-SEEDNSKLTKISILRIVM-QGVRTIRE- Fused_Spur --QGLDTCVEGKRKMAASLG----------DLFAEPSHHVLTDNLMKYIA-HPSFCEN-- Fused_Mmus --VGLPSCWDAKEQVSWHLA----------NQLTEDSSQ-LRPSLISGLR-HHVLCLH-- tsunami_Ddis --LSSSTTTAATATATTSAATTS----TATNSSQQQQQQP-IPSSIEVEVEIVLQCFHNI fu_Dmel --CLLPG-WDSC------------------------------------------------ AqueK209_Aque ------QC---------------------------------------------------- GK069_Glam LYQGLPVCAYVNVKQGEG---------GTDKILIDKNAQ------LDYLD-KEDVRVN-- Fused_Hsap ----------------------------LLKVLYSCCLVSEGLCRLL---------GQEP 1647_Tthe ---------------------------LIDKILTNRLMLTTLQQNMY---------SDEP Fused_Spur ----------------------------ALKTIYFGCQMSPQLSKYI---------ACKE Fused_Mmus ----------------------------LLKVLYACCYISERLCHIL---------GQEP tsunami_Ddis LYTSPQHAFEFPLEPKRNYQTNTSIQTYLMNYYQACVIIGDGLSSEIIINLLLCSISSYP fu_Dmel --------------------------------------------------------DES- AqueK209_Aque ------------------------------------------------------------ GK069_Glam ----------------------------ALLTLYNCAFCSEDYARNL---------SQIT Fused_Hsap LALE-------------------------------------------------------- 1647_Tthe FING-------------------------------------------------------- Fused_Spur EHVS-------------------------------------------------------- Fused_Mmus LALE-------------------------------------------------------- tsunami_Ddis HLRKIILQLSLHCLRGSKLFAESISKEEKSLIYPINQNNNNNNNNNNNNQNKNNNNSNSN fu_Dmel ------------------------------------------------------------ AqueK209_Aque ------------------------------------------------------------ GK069_Glam FPIS-------------------------------------------------------- Fused_Hsap ------------------------------------------------------------ 1647_Tthe ------------------------------------------------------------ Fused_Spur ------------------------------------------------------------ Fused_Mmus ------------------------------------------------------------ tsunami_Ddis PSTPNLQFQNSYNSPYNTINNNKPRSFFDYLSIKNINQSNNNNNNNNNNNNNNNNNNNNN fu_Dmel ------------------------------------------------------------ AqueK209_Aque ------------------------------------------------------------ GK069_Glam ------------------------------------------------------------ Fused_Hsap --------------SLFM-------------LIQGKVKVVDWEEST--EVTLYFLSLL-- 1647_Tthe --------------TAMQ-------------IMIHIMKHLSSKKDT--QIDLQINV---- Fused_Spur --------------LILL-------------VLQGKTEIEDMSQNTVYEMCTHILSTL-- Fused_Mmus --------------SLLM-------------LVQGKVKVADWEEST--EVALYLLSLL-- tsunami_Ddis LNTESTIEFNQEQKSLVLLILS--------AILIHSKESIDWMIHY----DLVDLS---- fu_Dmel ------------------------------------------------------------ AqueK209_Aque ---------------------------------------AAWMETK--DK---------- GK069_Glam --------------DVITENKDETKLSVITMLAISCLWLQAHGEEDDL--RLSLFGLLLT Fused_Hsap -------------------------------------VFRLQNLPCGMEKLGSD------ 1647_Tthe -------------------------------------QFILDNLEKN------------- Fused_Spur -------------------------------------TVQLQAIPEILLN---------- Fused_Mmus -------------------------------------VFRLQDLPSGMEKLGSE------ tsunami_Ddis -------------------------------------I---------------------- fu_Dmel ------------------------------------------------------------ AqueK209_Aque ------------------------------------------------------------ GK069_Glam SNFEYNMNCLQRDSEYLVKLYKPDSMSTIKDLVLLSLVRRVSVFAGSVEESLAEARLIMN Fused_Hsap ------VATLFTHSHVVSLVS--------------------------------------- 1647_Tthe ---------VWNH-PIVAIIS--------------------------------------- Fused_Spur ------------------------------------------------------------ Fused_Mmus ------VATLFTHSHVVSLVN--------------------------------------- tsunami_Ddis ---------RYFQNTDIRISS--------------------------------------- fu_Dmel -----------------QSPPIEN------------------------------------ AqueK209_Aque ---------------LAEIIS--------------------------------------- GK069_Glam GSSYSRVDDVYTKAQDDAVISSNPQDFNILSHGALRVERIMRELIKAGGIIDYGHSDFDG Fused_Hsap ------------------------------------------------------------ 1647_Tthe ------------------------------------------------------------ Fused_Spur ------------------------------------------------------------ Fused_Mmus ------------------------------------------------------------ tsunami_Ddis ------------------------------------------------------------ fu_Dmel ---------------------------------------DEWLAFLNRSVQELLDGELD- AqueK209_Aque ------------------------------------------------------------ GK069_Glam GFDRYNYPKLTDVHIDFNVRQLRRSYYYLSTGTAIEVPSINNYLELEVPVPVFYAC-IDA Fused_Hsap -------------------AAACLLGQLGQQGVTFDLQP--M--------------EWMA 1647_Tthe -------------------I--NLLAEILQNDSALSVAI--IQKFQNVNS--YKLLTELL Fused_Spur ------------------------------------------------------------ Fused_Mmus -------------------AAACLLGQLGQQGVTFDLQP--R--------------EWIA tsunami_Ddis -------------------SASYFLSGFLTVSINYEKEF--D----NFNNNLNNSNNNLI fu_Dmel -----------SLKQ-HNL--VSIIVAPLRNSKAIPRVLKSV--------------AQLL AqueK209_Aque -------------------S-------------------------NAPNS--EKDLTELL GK069_Glam ITPILKHCKDISIKQPHNSTVYSVLASESREGVIADCIGISR--------------AIFA Fused_Hsap AATH------------------------------------------ALSAPAEVR-LT-- 1647_Tthe NPTK------------------------------------------KVNKIEEIR-NIEG Fused_Spur ------------------------------------------------------------ Fused_Mmus AAAH------------------------------------------ALSAPAEVR-LT-- tsunami_Ddis RPTSPNSNNLIINGTNSLIDNQLTIIIDSIIQVIPIKNIRKLFSAKRV-EGNTMR-DLEG fu_Dmel SLPF------------------------------------------VLVDPVLIVDL--- AqueK209_Aque RPWL-------------------------------------------------------- GK069_Glam SLDY------------------------------------------VLVEPSFRAFLM-- Fused_Hsap ---PPG-SCGFYDGLLILLLQLLTE-QGKASL------IRDMSSSEMWTVLWHRFSMVLR 1647_Tthe SGFGCP-VYGFNDGIINFLQRLLFR-YHR-EHRKLSELFALFEQSGIDNSILNILT---- Fused_Spur ------------------------------------------------------------ Fused_Mmus ---PPY-SCGFYDGLLILLLQLLMQVQGKPGL------IRDVVGSEVWTILWHRFSMALR tsunami_Ddis GCFGKP-NIGMLDGVVCILLRMLKR-GGQ-EF------LETMLESGIWEALCHQIS---- fu_Dmel ------------------------------------EL---------------IRNVYVD AqueK209_Aque -----------------------------------S------------------------ GK069_Glam ---PCHNYVGFLDSALNYINILA-QEH-I----DVLPL-------------FVKLSVYLN Fused_Hsap LPEEASAQEGE------------------------------LSLS--------------- 1647_Tthe ------------------------------------------------------------ Fused_Spur ------------------------------------------------------------ Fused_Mmus LPEEVSAQEDD------------------------------LLLS--------------- tsunami_Ddis ------------------------------------------------------------ fu_Dmel VK----LVPNLMY-ACK---------LLLSHKQLSDSAAS-----------------APL AqueK209_Aque ------------------------------------------------------------ GK069_Glam LS----LYNSIEAAFCAAYAAPHHGAILGEEESTATSVSSTVSLGTPLLSARPAEMKTPI Fused_Hsap -------------------SPPSPEPDW-------------------------------- 1647_Tthe --------------------TLNS---K-------------------------------- Fused_Spur ------------------------------------------------------------ Fused_Mmus -------------------SPSSLEPDW-------------------------------- tsunami_Ddis --------------------STTS---E-------------------------------- fu_Dmel TTGSLSRTLRSIPEL----------------TVEE------------------------- AqueK209_Aque ------------------------------------------------------------ GK069_Glam LTPSQSLKLTSRPPSYGAHTPNANEHDLPEVTTSRSTARGKTPLKLGSYSTKPAVLYEQK Fused_Hsap ------------------------------------------------------------ 1647_Tthe ------------------------------------------------------------ Fused_Spur ------------------------------------------------------------ Fused_Mmus ------------------------------------------------------------ tsunami_Ddis ------------------------------------------------------------ fu_Dmel ------------------------------------------------------------ AqueK209_Aque ------------------------------------------------------------ GK069_Glam SETGYPIISTYLGPGSTHYNGILMCSLINNCSDCMADCLGLDTRRYDLGGLEGRNQEISN Fused_Hsap ------TLISPQGMAALLSLAMATF------------------------------TQEPQ 1647_Tthe ------SDISPKGFVSFLILIHDTI------------------------------ISDFV Fused_Spur ------------------------------------------------------------ Fused_Mmus ------TLISPQGMAALLSLAMAIF------------------------------TQESQ tsunami_Ddis ------IELSPHGIIHSLRVIYEVL------------------------------SSDTD fu_Dmel ------------------------------------------------------------ AqueK209_Aque ------------------------------------------------------------ GK069_Glam ANWHWRFLASPQGLIKYIISVRNTLSLLANKRVSGLTDPPGDVNYNSAGWTAISSIDEFN Fused_Hsap LCLSCLSQHGSILMSILKHLLCPSFLNQLRQAPH--GSEF--LP-VVVLSVCQL---LCF 1647_Tthe QFSNKIFQE--KVLLILCELLKESQLKALNEWPSSYGGGMMCVH-LITAQLLRI---FNL Fused_Spur ------------------------------------------------------------ Fused_Mmus LCLSHLSQHGSVLMLTLKHLLSPSFLHHLSQAPQ--GPEF--LP-VVVLSVCKL---LCF tsunami_Ddis HI-PYLVKN--NLLTSLCNLLDSGHLERIKEWPSLQMGSVSGIS-ALANQIFFI---LYL fu_Dmel ------------------------------------------LETACSLYE-LVCHLVHL AqueK209_Aque ------------------------------------------------------------ GK069_Glam QYMSYPLP-E--VVRTLCAAISPQSLDNIILCPYQFGGGQRAAETLMRYALLAIYQIVYL Fused_Hsap PFALDMDA---DLLIGVLADL-------------------------------RDSEVAAH 1647_Tthe PFTHPSQE---NDLERITREL-------------------------------NNSEIILS Fused_Spur ------------------------------------------------------------ Fused_Mmus PFALDVDA---DLLVGVLADL-------------------------------RASEVVVC tsunami_Ddis PLSSNAKDRIGDPMIELIRHI------------------------------MLAQELVRN fu_Dmel Q----------------------------------------------------------- AqueK209_Aque -----------------------------------------------------KANFL-- GK069_Glam S-CRPSTEKIGDRMEELKRTTNTTKKDKHTDTARLVYDPDRYYMTEYVSSVLLEFNFIKH Fused_Hsap LLQVCCYHLPLMQV-ELPISLLTRLALM---D--PTSLNQFVNTVS------ASPRTIVS 1647_Tthe TLKT-IQYLQKDHI-GIAIQLLSRLILNTEDD--KQFAAQFVSNNG------LYIIKKYN Fused_Spur ------------------------------------------------------------ Fused_Mmus LLQVCCHHLSLLQA-ELPIGLLTRLALT---D--SASLKQFVNTVA------TSSRAIIS tsunami_Ddis IIML-LPQIPSDSI-DLPLGLLSNIILE---D--SKFANQFIEFGG------LEPNTAQL fu_Dmel -----------------------------Q-----QFLTQFCDAVAILAASDLFLNFLTH AqueK209_Aque ------------------------------------------------------------ GK069_Glam VIDS-LYYLRSFHTLYYALVTMVFFAMHPQDSIVIPWINQFIFSGG------VSMNLLSA Fused_Hsap FLSVALLSDQ----PLLTSDLLSLLAHTARVLSPSHLSFIQELLAGSDESYR-PLRSLLG 1647_Tthe LLHHEN-P------HPLIVDTLNILSQLARISKNY-YDNIH-----VIDIYQ-ELKKLIV Fused_Spur --------SS----PLFAAILLD------------------------------------- Fused_Mmus FLSVVLLSDQ----PLMISDLLSLLTHTARILSPSHLSFIQELLSGSDESYR-PLRSLLG tsunami_Ddis ILNPDRIS------PSTLVDSLIIFSQLARISQDN-YKAMH-----RSDLYG-LLKKLLA fu_Dmel DFRQSDSDAASVRLAGCMLALMGCVLREL---PE-NAELVE----RIVFNPRLNFVSLLQ AqueK209_Aque ------------------------------------------------------------ GK069_Glam IFSQKNISQRN-NPHSCILEILILLLRAVQVSQE-YAELVS----NTISAST-IIQFLSF Fused_Hsap HPENSVRAHTYRLLGHLLQHSMALRGALQSQSGLLSLLLLGLGDK--DPVVRCSASFAVG 1647_Tthe HKEGSVRAKVCNFIGNICRHSSYFYEMLL-KNDLISACIECCKDS--DKATRKFACFAVG Fused_Spur ---------------------------------------SQIASH--T------------ Fused_Mmus HSENTVRVRAYGLLGHLLQHSMALRGALQSQSGLLNLLLLGLGDK--DPAVRRSASFAVG tsunami_Ddis HPEATVRAKTCNLIGNMFKYNGYFYQHFQ-KSGILPILISRCIDV--DLNTRKFACFALG fu_Dmel SRHHLLRQRSCQLLRLLARFSLRGVQ--RIWNGELRFALQQLSEHHSYPALRGEA----- AqueK209_Aque ------------------------------------------------------------ GK069_Glam ESSEELIVKSCEFVGYLIKARPTASE--QYKTCL-DSLIELIKTR--RTAIVTKSLFAMM Fused_Hsap NAAYQAGPLGPALAAAVPSMTQLLGD--------------------------------PQ 1647_Tthe NAGFHNAALYEHLRPVVPLLVDLLKD--------------------------------PE Fused_Spur ----VSGPEGEAF-----------GD--------------------------------RW Fused_Mmus NAAYQAGPLGPALAAAVPSMTQLLGD--------------------------------AQ tsunami_Ddis NAAFHSSDLYDELDDSIPILKKLLNNEYPFSGQQQQQQSQQQQQSQQQQQNDLLLQIEED fu_Dmel ------------------------------------------------------------ AqueK209_Aque ----------------------------------------------------------PE GK069_Glam HIAKTVDD-AFSLSKCIGCICKTLMNAR----------------------------VLDD Fused_Hsap AGIRRNVASALGNLG--PEGLGEELLQCEVPQRLL--------------------EMACG 1647_Tthe EKTRANAAGALGNFVRNSDTLTQDLIKHRALHAML--------------------DVVLN Fused_Spur EQMCGVAIGGLAELV--------------------------------------------- Fused_Mmus DGIRRNAASALGNLG--PEGLGKELLKCQVPQRLL--------------------EMACG tsunami_Ddis EKTRSNVIGALGNLVRNSSQLCQKMIDSGILDALT--------------------S-YLD fu_Dmel --------------------------------------------------AQTLDE---- AqueK209_Aque EGTR-------------------------------------------------------- GK069_Glam IKTCAAVASAKIIL--AHEELATEFVSGEGVISLVDCMSSCDQLSDKMIYAKVLLELAKF Fused_Hsap DPQP--NVKEAALIALRSLQQEPGIHQVLVS-LGASEK----LSLLSLGN-QSLPHSSPR 1647_Tthe DMGPSLSPKRIALFSIGNLCVYPECRKVYME-MNIQAI----IKQIQDGN-NQD------ Fused_Spur --------------------------------------------YLQQG----------L Fused_Mmus DPQP--TVKEAALIALRSLQQESCIHQVLVS-LGASEK----LALLSLGN-QLLPNSSNR tsunami_Ddis EYKSHTNILKSVLFSLGNFSVYEQCRYILIEDYDLDSTLDDLFEYLKQNQQQID------ fu_Dmel ------------------------------------------------------------ AqueK209_Aque ------------------------------------------------------------ GK069_Glam DPVT--TALKSQASLLRMIDRDCDD-HALKS----------L------------------ Fused_Hsap PASAKH----CRKLIHL--------------------LRPAHSM 1647_Tthe PQIQKYAARIQQKLSKLIIRTCNNENRISVIKKFFIKQPTVKYK Fused_Spur DTCVEG----KRKVGQR---------------------SCPCKT Fused_Mmus PASVRH----CRKLIQL--------------------LRPTHST tsunami_Ddis PTIIKY----INRIKK---------------------ILRSPST fu_Dmel -------------IS----------------------HFTFFVT AqueK209_Aque --TVTECIEIVSILIK---------------------LVKEDVM GK069_Glam -------------LENL--------------------LITSKRM :