CLUSTAL W (1.83) multiple sequence alignment GAK_Hsap M----------------------------------------------------------- GAK_Mmus M----------------------------------------------------------- F46G11.3_Cele M----------------------------------------------------------- auxillin_Dmel M----------------------------------------------------------- GAK_Spur M----------------------------------------------------------- AqueK171_Aque MAEGGKSAKAVFKEVVPELTRILGREPPFTIVTASLNAKDLITDAELCAIRREGLTNDQR AqueK172_Aque M----------------------------------------------------------- * GAK_Hsap ------------------------------------------------------------ GAK_Mmus ------------------------------------------------------------ F46G11.3_Cele ------------------------------------------------------------ auxillin_Dmel ------------------------------------------------------------ GAK_Spur ------------------------------------------------------------ AqueK171_Aque GNEVAEKLKEKIGDSEDPNACLLKICDVFESKTVDCPTLKDYGAKMRKSISTNGTSDGAE AqueK172_Aque ------------------------------------------------------------ GAK_Hsap ------------------------------------------------------------ GAK_Mmus ------------------------------------------------------------ F46G11.3_Cele ------------------------------------------------------------ auxillin_Dmel ------------------------------------------------------------ GAK_Spur ------------------------------------------------------------ AqueK171_Aque QLDAKDVDKILEVLDKVLFGAIKWNDLGLRLGLYQPRLNVISDGGGDAYRHLRKTIEAWL AqueK172_Aque ------------------------------------------------------------ GAK_Hsap ------------------S-LLQSA-LDFLA--------GPGSLGGASGRDQSDFVGQTV GAK_Mmus ------------------S-LLQSA-LDFLA--------GPGSLGGAAGRDQSDFVGQTV F46G11.3_Cele ------------------A-F-ARA-LGVIQ--------SVGRGAGISEQSELYDRGQTF auxillin_Dmel ------------------GEFFKSLNLNYFSSSEVNGAAGNGAPEALGGRLDNDFVGQVV GAK_Spur ------------------TDLFRSA-FGILG--------GP------SDRG-NEFVGQQV AqueK171_Aque DGKDDARSRTWQTLIDAMVDFFRSA-MSYLS--------GEGDVGGGSGG-GNAFVGQTV AqueK172_Aque ------------------VDFFRSA-MSYLS--------GEGDVGGGSGG-GNAFVGQTV : :. : . . ** . GAK_Hsap ELGE-LRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKL GAK_Mmus ELGE-LRLRVRRVLAEGGFAFVYEAQDLGSGREYALKRLLSNEEEKNRAIIQEVCFLKKL F46G11.3_Cele SING-NNYRVEKVIAKGGFGTVFLATNT-KGKQVAVKIMLSHDAAATKDIDNEIDMMKKL auxillin_Dmel EVAG-HRLRIKCVIAEGGYAFVYVAQDVQTGTEYALKRLIGADMQASTAIINEINIHKQL GAK_Spur ELGD-TKLKVRRVIAE-GFAFVYVAQENSTGKEFALKRLLANDEEKSKEILQEIAILxxx AqueK171_Aque DIGDGMKLKVKKVIAEGGYGFVFVAQDTSTGIDYALKRQIVAS-ENIKAIKQEITFLTQL AqueK172_Aque DIGDGMKLKVKKVIAEGGYGFVFVAQDTSTGIDYALKRQIVAS-ENIKAIKQEITFLTQL .: . ::. *:*: *:. *: * : .* : *:* : . * :*: : GAK_Hsap SGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKG-QLVEFLKKMESRGPLSCDTVLKI GAK_Mmus SGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKG-QLVEFLKRVECKGPLSCDSILKI F46G11.3_Cele Q-HENIIQLFDASAE-SRSSNRSVKEYKISMEYCKF-SIADVLL-KY--KEVSIDFVVRI auxillin_Dmel SGHENIVAFVGSSYT--APSTQLGAQYLLLTELCKGGSLVDCFRT--NNAPFNPTCVLRI GAK_Spur xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-xxxxxxxxxxxxxxxxxxxxxxx AqueK171_Aque SGHPHIIHFIGAASS--KDPAGGSAEFLIVTELITGGELVDIVNT----RSLSPHQVLRV AqueK172_Aque SGHPHIINFIGAASS--KDPAGGSAEFLIVTELITGGELVDIVNT----RPLSPRQVLRV GAK_Hsap FYQTCRAVQHMHRQKPPIIHRDLK--VENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQ GAK_Mmus FYQTCRAVQHMHRQKPPIIHRDLK--VENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQ F46G11.3_Cele IYFTTRALVYLHSV--GAIHRDIK--AENLLINGNGKLKLCDFGSATTKSIEM-APLSNS auxillin_Dmel FYQMARAVASLHSQSPPIAHRDIK--IENFLIGNDKQIKLCDFGSASTEVLSPTFEWSAN GAK_Spur xxxxxxxxxxxxxxxxxxxxxxxx--LENFLIGSKKTLKLCDFGSATSKSYQPDSSWSSL AqueK171_Aque FYETCQAIAHMHSQTPPIIHRDIKVGVENLLLTDKGSVKLCDFGSATTQRLTPDHSWSAT AqueK172_Aque FYETCQAIAHMHSQTPPIIHRDIKVGVENLLLTDKGSVKLCDFGSATTQRLTPDHSWSAT **:*: .. :********:: * GAK_Hsap RRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKL GAK_Mmus KRAMVEEEITRNTTPMYRTPEIVDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKL F46G11.3_Cele ERLAVQEEMFKYTTPITRSPEVCDVYSNWPIGKQQDNWAMGCLIYFVAFGEHPF-DGSAL auxillin_Dmel QRSMLEDQLNTVTTPMYRSPEMLDTWSNNPIGPKVDIWALGCILYFLCYRKHPYEDGGKL GAK_Spur KRSTLEDEFARHTTPMYRPPEILDLYENFPINHAMDVWALGCMLYTMCYRQHPFEDSAKL AqueK171_Aque QRGLREDE---------------------------------------------------- AqueK172_Aque QRGLTEDEIQANTTPMYRAPEMIDLYSNYPINEKGDIWALGCLLYKLCFQEHPFEDSAKL .* ::: GAK_Hsap RIVNGKYSIPPH--DTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQEIAAARNVN--PK GAK_Mmus RIVNGKYSIPVN--DTRYTVFHDLIRAMLKVNPEERLSIAEVVRQLQEIAAARNVN--PK F46G11.3_Cele AIINGKYKKPPPVQQNQLSAFADLIAKCLTPNPDERITAAKIEEYM-KLAMQKQPKLAAK auxillin_Dmel RIINANYMLPP---DPQYQCFSDIIRGCLKVNPFERLDITMVLEGLAALAETHNWS--LK GAK_Spur RIINANYTIPED--DEEYMILHDLIRAMLQVDPRNRPPLEVIVAQLQEIAAAREVT--LK AqueK171_Aque ------------------------------------------------------------ AqueK172_Aque RILNANYHIPPG--DNVYKEFHNIIRSCLVVDPTKRPSVDSIVAQLYPIADKFGEN--FD GAK_Hsap SPI-T-ELLE-QNGGY-GSATLSRGPPPPVGPAGSGYSGGLALAEYDQPYGGFLDILRGG GAK_Mmus API-T-ELLE-QNGGY-GNSGPSRAQPPCGGTVNS--SGVLALAEYDQPYGGFLDILRGG F46G11.3_Cele TDF-TDILDLMNVQPVQ-AEQS----------------------IESQAAKGFFTM---- auxillin_Dmel GPL-D-LHIM-PIESL-PAESPLKSSAY--SEVYTEP-LSAAIPSSYNGHGSLLSSLRGG GAK_Spur GPL-R-MLDS-RASPVQHTASPAKRAPERE-------------GDSVDSAGNFLGMMKGA AqueK171_Aque ------------------------------------------------------------ AqueK172_Aque KPPKE-PLIS-GVQSQ-SVSDPTESDSS--GGINA----ASALHATSHQAQKLFGFMKGG GAK_Hsap TERLFTNLKDTSSKVIQSVA-NYAKGDLDISYITSRIAVMSFPAEGVESAL-KNNIEDVR GAK_Mmus TERLFTNLKDTSSKVIQSVA-NYAKGDLDISYITSRIAVMSFPAEGVESAI-KNNIEDVR F46G11.3_Cele QDKLFSNLTSLKNTVVQQTN-KMGWG-MEPTNTTP------------------------- auxillin_Dmel AGTLLKNIKDTSTKVMQTMQQSLARNDLDISHITSRILVMPCPSDGFESTYKTNNIEDVR GAK_Spur GGNLLRNLKDTSSRVAQTVA-SYTKSELDISYITSRIIVMSFPAEGLESTY-KNGIDDVR AqueK171_Aque ------NIKDTSNKVISSVQ-NPKQKSTDITYVTSRILVMSYPFEEGGVGR-PNVLKEVA AqueK172_Aque AENLFKNIKDTSNKVISSVQ-NPKQKSTDITYVTSRILVMSYPFEEGGVGR-PNVLKEVS *:.. .. * . . : : *. GAK_Hsap LFLDSKH-PGHYAVYNLSPRTYR----PSRFHNRVSECGWAARRAPHLHTLYNICRNMHA GAK_Mmus MFLDAKH-PGHYAVYNLSPRIYR----ASKFHNRVTECGWAVRRAPHLHSLYTLCRSMHA F46G11.3_Cele ------------------------------------------------------------ auxillin_Dmel LSLESRFVPQKLSIYNFGQRTEPRLPPPVRTVEAGSVYGCPQAHAPNLQGLFTVSADMYN GAK_Spur SFLETRH-SGHYHVFNLSQRTYR----PAKFENRVSDCGFPAKRPPNLVLLYHVCRNMYL AqueK171_Aque AYLEGTH-PSQYLVFNLSGEQYD----TDQLSGQVVDYEWPNRAMPPLESLVELCRQLDS AqueK172_Aque AYLEGTH-PSQYLVFNLSGEQYD----TDQLSGQVVDYEWPNRAMPPLESLVELCRQLDS GAK_Hsap WLRQDHKNVCVVHCMD-GRAASAVAVCSFLCFCRLFSTAEAAVYMFSMKRCPPG----IW GAK_Mmus WLREDHRNVCVVHCMD-GRAASAVAVCAFLCFCRLFSTAEAAVYMFSMKRCPPG----IW F46G11.3_Cele ------------------------------------------------------------ auxillin_Dmel FLNADPKSVVIVQTGDSGGCTAATVICALLMYADLLREPEDAVQVFAVKRHTIN----LR GAK_Spur WMQRDPKNVCVIHCMD-GKASSATIVSSFLTFCRLFSTVDVSLYMFSVKRGPPG----IT AqueK171_Aque WLRADFKNVLVIHCKD-GVHPSGILVVSYLLFLRALPSPSSALRLFTARRLPEGQGMDIS AqueK172_Aque WLRADFKNVLVIHCKD-GVHPSGILVVSYLLFLRALPSPSSALRLFTARRLPEGQGMDIS GAK_Hsap PSHKRYIEYMCDMVAE-EPITPHSKPILVRAVVMTPVPLFSKQRSGC---RPFCEVYVGD GAK_Mmus PSHKRYIEYVCDMVAE-EPITPHSKPMLVKSVVMTPVPLFSKQRNGC---RPFCEVYVGE F46G11.3_Cele ------------------------------------------------------------ auxillin_Dmel PSEFRYLYYFGDILRP-TPLLPHYKNTTLVSLSCQPVPRMTKARDGC---RIYMEVYCNG GAK_Spur QSQKRYMEYISGMLSPTASIMPHQRVLLIKSLRLTPVPLYNKMRSGCPSVRPYVRTSVPD AqueK171_Aque PSD--------------------------------------------------------- AqueK172_Aque PSDRRYLNYMMALSRP-APYKPHPHSFKLTGLNLTSVPIYNEARNGC---KPFVEVFVDG GAK_Hsap ERVASTS--QEYDKMRDFKIEDGKAVIPLGVTVQGDVLIVIYHARST-LGGRLQAKMASM GAK_Mmus ERVTTTS--QEYDRMKEFKIEDGKAVIPLGVTVQGDVLIIIYHARAT-LGGRLQAKMASM F46G11.3_Cele ------------------------------------------------------------ auxillin_Dmel NLLLSTL--QDYEKMRLYQAGPGKIVLPINLTACGDVTVVLFHARKG-M-----VRPQGL GAK_Spur ELIRFGG--HEVKGQRGFEVEDASAFIDLNIPVCGDVMVVVYHARST-FGGKVQGKVTGL AqueK171_Aque ------------------------------------------------------------ AqueK172_Aque ERVHTSCNKENMDKLKEYTTKDGQISIPLNTTVYGNLLIIVHHIKSVPLTKRAEMGMSAV GAK_Hsap KMFQIQFHTGFVPRNATTVKFAKYDLDACDI--QEKYPDLFQVNLEVEVEPRDRPSREAP GAK_Mmus KMFQIQFHTGFVPRNATTVKFAKYDLDACDI--QEKYPDLFQVNLEVEVEPRDRPSREAP F46G11.3_Cele -----------------------------------------------------------R auxillin_Dmel KICQFQFNTGFIPEPETLITFTNQDLDDLPD--PEQVTPRFCVSLSLAVTDSESPPSHKP GAK_Spur KMFQFQFNTGFIEPGTKEISFNRYELDFFEL---DKFAEHFHASLDVVVSEKDRPSQKPP AqueK171_Aque ------------------------------------------------------------ AqueK172_Aque KMFKFQIHTGFLSTKMTSLTLEKNELDGSAVKKTDRFPSSFKVLLNFSVQEAV--QNAGV GAK_Hsap PWENSSMRGLNPKILFSSREEQQDILSKFGKP--ELPRQPGSTAQYDAGAGSPEAEP-T- GAK_Mmus PWENTSLRGLNPKILFSNREEQQDILSKFGKP--ELPRQPGSTAQYDAEAGSPEAEI-T- F46G11.3_Cele PGHPSTSPKLVPKTHRSNQQQ-------------------------------EKNAP--P auxillin_Dmel PWMPAKPK-RSPAALFSSDLEYAEMLDNFVT-------KPS-----------------T- GAK_Spur PWTTFETKRLTPKYCFSGQEEWDSVTAQFGQMDAKAQRRLE--KERSEQQ-PSESKPTAP AqueK171_Aque ------------------------------------------------------------ AqueK172_Aque AWQNLPHAQATPMTCFSTMEEQGDVFKLFGGSIQELQKKPP-----------------T- GAK_Hsap DSDSPPSS-SA-------DASRFLHTLDWQEEKEAETGAENASSKESESALMEDRDESEV GAK_Mmus ESDSPQSS-ST-------DTNHFLHTLDWQEEKEPETGLDNTSPKESQSVLIADGDGSEV F46G11.3_Cele RP----PTTASPRAAPVATFKVSWP-----T----------------------------- auxillin_Dmel RSSPPPGARKSD------RVSSPL--VL-PDVTE-------------------------T GAK_Spur RQTTPPPKQAAPREAPAEAKKPFFQTLDWQEGGPPQTEGHVRLPTQEHETLIDDDDDSDD AqueK171_Aque ------------------------------------------------------------ AqueK172_Aque HQTTPPVQQTTP------SLEGYGQLLD-EDSSEPATGNLL-GDTGAAGNLFGETGGTNL GAK_Hsap SDEG--------------GSPISSEGQEPRADPEPPGLA--------AGLVQQDLVFEVE GAK_Mmus SDEE--------------EASFPSEERKPGAGEDTPRLA--------AGTKQQDLIFDVG F46G11.3_Cele ------------D---------------------------------SSQNDSANDWGDFS auxillin_Dmel AH-EL-------------PSPM--------PEPSPP------------------------ GAK_Spur DDFNSFQAQRLSEMSQNSTVSQSQQSQGQGSGNDANFFQSDINETSQSSTNQENLFADFS AqueK171_Aque ------------------------------------------------------------ AqueK172_Aque ADFVG-------------YASYRTPGQSGGAESDSSSDS--------SG----------- GAK_Hsap TPAVLPEPVPQEDGVDLLGLHS--EVGAGPAVPPQACKAPSSNT---DLLSCLLGPPEAA GAK_Mmus MLAAPQEPVQPEEGVDLLGLHS--EGDLRPAAPLQACGVPSSNT---DLLSCLLEPSDAA F46G11.3_Cele -----QA----------------------------------------------------- auxillin_Dmel --------------IDLLNLNQ--QPSDVPAADPLTSAKPSTDA-SFDLLGAF-GDDDST GAK_Spur -----SAMSQSEQTTDLLNIGGESTPASQPAVEPDLMAPPPRDPTNFDLLV---DSTAEL AqueK171_Aque ------------------------------------------------------------ AqueK172_Aque --------------CSSSSSDS--EGGDVPTSSPR---QPTVSV-DDDLEAFF-SNPAAS GAK_Hsap SQG--P-----PEDLL-SEDPLLLASPA--PPLSVQSTPRGGPPAAADPFGPLLPSSGN- GAK_Mmus QVG--P-----PGDLLGGEAPLLLASPV--SPLGLQNNLQGKVPDTVDPFDQFLLSSNS- F46G11.3_Cele ----PPAVNVS------------------------------------------------- auxillin_Dmel GIGSAP-----IPDIL-PPPPLQ-----------QP-----QPKINNDPFDIFG-SVD-Q GAK_Spur NMGTSPAGNGQSKD---TFDPFMQAKPS--QPSAPKQTKAQEKPFDNVKFDPFASQPTSQ AqueK171_Aque ------------------------------------------------------------ AqueK172_Aque NIEEGN-----LLELG-STPPVKTASSNVSNTSSTR-----QTSFGNDPFAGFEWTHSTT GAK_Hsap ----------NSQP----CSNPDLFGEFLNSD------------------------SVTV GAK_Mmus ----------DTQP----CSKPDLFGEFLNSD------------------------SVAS F46G11.3_Cele --------------------KKDVFDPFSE---------------SASH----------- auxillin_Dmel G----------GVP----SMKPSGFPPFVGS--------------------------LPT GAK_Spur QGTPKATPKQESQPSS-AGAKNNLFDPFASFGQPSPSMSGTSSQPSPASASKPLFDPFGA AqueK171_Aque ------------------------------------------------------------ AqueK172_Aque NHPPPS-TSNNSAPASNKASTSSGFDPFAPSS---------------GGAGEDLMNLMGT GAK_Hsap PPSFPSAHS-----------APPPSCSADF----LH-LGDLPGEP----SKMTASSSNPD GAK_Mmus STAFPSTHS-----------APPPSCSTAF----LHLVGDLPAEP----SKVIASSSHPD F46G11.3_Cele ---------NLSAK----------------HSED-------------------------- auxillin_Dmel FVAQPAATT-----------NPSPT----------------------------------- GAK_Spur ---QPRSTPSPTPASTSNLSAPQGGMTRQTHSSDNL-LGDLGSFSQNGGPTLKQSNSGPD AqueK171_Aque ------------------------------------------------------------ AqueK172_Aque TPLLPTATS-----------APTTM-SSQT----RF-SGNLGATR----SGMYPSSSG-- GAK_Hsap LLGGWAAWTETAASAVAPTPATEGPLFSPGGQPAPCGSQASWTKSQNPDPFADLGDLSSG GAK_Mmus LLGGWDTWADTATPGPASIPVPEGTLFSSAGHPAPPGPNPSQTKSQNLDPFADLSDLSSS F46G11.3_Cele -LLSLQNWPGTAE------HK--------------P-----EVRSQSSRDLFDFDDLMLR auxillin_Dmel -----------------------------------------HPARASADPFANIADLATG GAK_Spur LMAGWNQGGPRST------PMQSGSNRTPQ-HSTRP-----TPPPAKVDPFSNFGNFSSP AqueK171_Aque ------------------------------------------------------------ AqueK172_Aque -YSGWASFTATSTTSKH-DEIPQDKRGGGGGSKA-------PPSSKSSDPFGDIWGQASG GAK_Hsap LQG-----SPAG------------------------FPPGGFIPKTATTPK--------- GAK_Mmus LQG-----LPAG------------------------LPAGGFVGAPAPTQK--------- F46G11.3_Cele H-T--------------------------------------------------------- auxillin_Dmel LNLNFNRSTLSGKSPVNTSPQPTQFSSPTHKPSPSSQPQATFMH-TPPTPQ--------- GAK_Spur S-PST-AGGPMGG-----------------------SPAMGGGGQPSPQKQRQSPGFGAG AqueK171_Aque ------------------------------------------------------------ AqueK172_Aque KSQQ------------QTSQAP-----PKATPTNQQQY---------------------- GAK_Hsap -----GSSSWQT--SRPPAQGASWPPQAKPPPKACTQPRPNYA-SN-F---SVIGAREER GAK_Mmus -----SNSPWQA--NRPTAPGTSWTPQAKPAPRASEQLR-----SH-F---SVIGAREER F46G11.3_Cele --TPSAES-----SQAVLQPIRQVENK--------NLTKVDVSK---------------- auxillin_Dmel -----TLPSTSS--IRTP-----TQPQAVPA-----QSRPDYSRLH-F---DSQKA---- GAK_Spur RQQPMMSSQAQSPSHRPFQPQSQTMPQKTATPPPPQAAKPNYFAGG-FASSSVIGGREER AqueK171_Aque ------------------------------------------------------------ AqueK172_Aque -----------------------KPTM---------SHRPTYQMYGGM-GGASDGARGNS GAK_Hsap GV------------------------RAPSFA----QKPKVSENDFEDLLSN-QGFSSRS GAK_Mmus GV------------------------RVPSFA----QKPKVSENDFEDLLPN-QGFSKS- F46G11.3_Cele ----------------------------NGI------GSSSSSASLDDMVSD-------- auxillin_Dmel -------------------------------AQQPGTGGSKNSDIFADILGQ-QGYSFGS GAK_Spur GK------------------------RDGGFM----TSKAAKQADFSNLLSDQQKFQASA AqueK171_Aque ------------------------------------------------------------ AqueK172_Aque GKGGVGGANSSKSGTGLRPPSRENVTRSPSPTQKFGPVPNRSKTQFNDLLDP-GLFTSSA GAK_Hsap D-KKGPKTIAEMRKQDLAKDTDPLKLKLLDWIEGKERNIRALLSTLHTVLWDGESRWTPV GAK_Mmus D-KKGPKTMAEMRKQELARDTDPLKLKLLDWIEGKERNIRALLSTLHTVLWDGESRWTPV F46G11.3_Cele ------------------------------------------------------------ auxillin_Dmel KMNQCPRSINEMRKEDLFKDMDPKKVRIMEWTDGKKNNIRALLCSMHTVLWDN-AKWQRC GAK_Spur K-SHETKTINDMKRKEIEATTDPNVLKVRDWTQGKENNIRALICSMHQVLWDGEDRWKPV AqueK171_Aque ------------------------------------------------------------ AqueK172_Aque KEKEGPTSLKDMRKK-VDVITDPERAKVADWAEGKEHNIRALISSLHTILWEGERRWKKV GAK_Hsap GMADLVAPEQVKKHYRRAVLAVHPDKAAGQPYEQHAKMIFMELNDAWSEFENQGSRP--- GAK_Mmus SMADLVTPEQVKKQYRRAVLVVHPDKATGQPYEQYAKMIFMELNDAWSEFENQGSRP--- F46G11.3_Cele -------------------------------------------------MMKM--ST--- auxillin_Dmel EMSTMVTPTEVKKAYRRACLAVHPDKHNGTENEEIAKLIFMELNNAWTDFENDATQQNMF GAK_Spur GMHQLVEHNQVKKWYRKAVLSAHPDKQVGTPNEELAKLIFMELSDAWSAFEEAGAQA--- AqueK171_Aque ------------------------------------------------------------ AqueK172_Aque GMHELVEADQVSKYFRKACLSVHPDKVD-ESNANLARAIFDELNDAYELFEQSGAKS--- GAK_Hsap LF GAK_Mmus LF F46G11.3_Cele KK auxillin_Dmel NA GAK_Spur LF AqueK171_Aque RR AqueK172_Aque LY