CLUSTAL W (1.83) multiple sequence alignment RHOK_Hsap MD-FGSLETVVANSAFIAARGSFDGSSSQPSRDKKYLAKLKLPPLSKCESLRDSLSLEFE GPRK7_Hsap MVDMGALDNLIANTAYLQARKPSDCDS---KELQRRRRSLALPGLQGCAELRQKLSLNFH GPRK6_Hsap M----ELENIVANTVLLKAREGGGG--NRKGKSKKWRQMLQFPHISQCEELRLSLERDYH GPRK5_Hsap M----ELENIVANTVLLKAREGGGG--KRKGKSKKWKEILKFPHISQCEDLRRTIDRDYC GPRK4_Hsap M----ELENIVANSLLLKARQGGYG--KKSGRSKKWKEILTLPPVSQCSELRHSIEKDYS Gprk2_Dmel M----ELENIVANTVYLKAREGGSD--SNKGKSKKWRKILQFPHISQCINLKDKLDISYG GPRK6_Mmus M----ELENIVANTVLLKAREGGGG--NRKGKSKKWRQMLQFPHISQCEELRLSLERDYH GPRK5_Mmus M----ELENIVANTVLLKAREGGGG--KRKGKSKKWKEILKFPHISQCEDLRRTIDRDYY GPRK4_Mmus M----ELENFVANNLLLKARLGF-N--KQTGRSKKWRELLKFPPVSMCTELRWSIEKDFS F19C6.1_Cele M----EIENIVANTVYIKARESG-G--QKKGKSKKWKNYLQFPHYTECLPLKTEIEVTYA RHOK_Mmus MD-FGSLETVVANSAFIAARGSFDGSSTPSSRDKKYLAKLRLPPLSKCEGLRDNLSLEFE GPRK_Spur ------------------------------------------------------------ AqueK008_Aque --------------------------------------MLKLPPVGTCLPLRDKIDHTFE RHOK_Hsap SVCLEQPIGKKLFQQFLQS-AEKHLPALELWKDIEDYDTADNDLQPQK--AQ-TILAQYL GPRK7_Hsap SLCEQQPIGRRLFRDFLAT-VPTFRKAATFLEDVQNWELAEEGPTKDS--ALQGLVATCA GPRK6_Hsap SLCERQPIGRLLFREFCAT-RPELSRCVAFLDGVAEYEVTPDDKRKAC--GR-QLTQNFL GPRK5_Hsap SLCDKQPIGRLLFRQFCET-RPGLECYIQFLDSVAEYEVTPDEKLGEK--GK-EIMTKYL GPRK4_Hsap SLCDKQPIGRRLFRQFCDT-KPTLKRHIEFLDAVAEYEVADDEDRSDC--GL-SILDRFF Gprk2_Dmel YVIDQQPIGRELFRLFCENKRPVYFRYITFLDEVVKYEIEYISNRIFI--GH-DIGRRFL GPRK6_Mmus SLCERQPIGRLLFREFCAT-RPELTRCTAFLDGVSEYEVTPDEKRKAC--GR-RLMQNFL GPRK5_Mmus SLCDKQPIGRLLFRQFCET-RPGLECYIQFLDLVAEYEITPDENLGAK--GK-EIMTKYL GPRK4_Mmus SLCDKQPIGRLLFRQFCDT-KPDLKRCIEFLDAVAEYEVTIEEEQREF--GL-AIFSRFF F19C6.1_Cele FVVEKQPIGKLLFHEFCQATNSQYHQCCQFLTKVEEYETSDDDGQSRRDLAS-SIVSLL- RHOK_Mmus SLCSEQPIGKRLFQQFLKT-DERHVPALELWKDIEDYDTADDDLRPQK--AQ-AILAEYL GPRK_Spur ------------------------------------------------------------ AqueK008_Aque FIVEQQPIGHKLFLLFCEK-DLKLSRCMQFLHAVDELKIVVEGKRLAH--AQ-TVFDDFL RHOK_Hsap DPQ-AK------------------------------------------------------ GPRK7_Hsap SAPAPG------------------------------------------------------ GPRK6_Hsap SHT-GP------------------------------------------------------ GPRK5_Hsap TPK-SP------------------------------------------------------ GPRK4_Hsap NDK-LA------------------------------------------------------ Gprk2_Dmel DVE-AQLELRNGSGGDALDAETQEELLLNSSNANPTETAETEHCNNTTANNCNNINNSNN GPRK6_Mmus SHT-GP------------------------------------------------------ GPRK5_Mmus TPK-SP------------------------------------------------------ GPRK4_Mmus KEK-SE------------------------------------------------------ F19C6.1_Cele -HS-KPED-------------------------NPSGSQ--------------------- RHOK_Mmus DPQ-GT------------------------------------------------------ GPRK_Spur ------------------------------------------------------------ AqueK008_Aque SLD-SPQD-------------------------QASKF---------------------- RHOK_Hsap ------------------------------------------------------------ GPRK7_Hsap ------------------------------------------------------------ GPRK6_Hsap ------------------------------------------------------------ GPRK5_Hsap ------------------------------------------------------------ GPRK4_Hsap ------------------------------------------------------------ Gprk2_Dmel SQHSSDINHKKLDTRNHNGDDATGNGSSHQDDGDESVKCQEGHDDAEKGGGGEGGGGGKC GPRK6_Mmus ------------------------------------------------------------ GPRK5_Mmus ------------------------------------------------------------ GPRK4_Mmus ------------------------------------------------------------ F19C6.1_Cele ------------------------------------------------------------ RHOK_Mmus ------------------------------------------------------------ GPRK_Spur ------------------------------------------------------------ AqueK008_Aque ------------------------------------------------------------ RHOK_Hsap ---------LFCSFLDEGIVAKFK----E-GPVE--IQDGLFQPLLQATLAHLGQAPFQE GPRK7_Hsap ---------NPQPFLSQAVATKCQ----A-ATTEE-ERVAAVTLAKAEAMAFLQEQPFKD GPRK6_Hsap ---------DLIPEVPRQLVTNCT----Q-RLEQ-GPCKDLFQELTRLTHEYLSVAPFAD GPRK5_Hsap ---------VFIAQVGQDLVSQTE----E-KLLQ-KPCKELFSACAQSVHEYLRGEPFHE GPRK4_Hsap ---------APLPEIPPDVVTECR----L-GLKEENPSKKAFEECTRVAHNYLRGEPFEE Gprk2_Dmel VPVGGYPDELVLDVLNDDLIAQVR----N-KLN--SGGKDIFAQCVNAVKAFLAGEPFRE GPRK6_Mmus ---------DLIPEVPRQLVSNCA----Q-RLEQ-GPCKDLFQELTRLTHEYLSTAPFAD GPRK5_Mmus ---------VFIAQVGQDLVSQTE----K-KLLQ-SPCKELFSACAQSVHDYLKGDPFHE GPRK4_Mmus ---------VPLPEIPPDIVKECK----W-NLKQNSPSQNVFEECAGIVCKYLSETPFEE F19C6.1_Cele -----DEQEFWCSFLSDEVISTCITTADSATHD-DEPRSDIFTEPYRLTCQYLTDAPFKE RHOK_Mmus ---------LFCNFLDQGMVTRVK----E-GPTG--SQDGLFQPLLQATMEHLSQAPFQE GPRK_Spur ------------------------------------------------------------ AqueK008_Aque ------LGAGKLECVSDELATKTQ----E-KLKG-IVPVDVFEECRQAVRDFLSGQPLID RHOK_Hsap YLGSLYFLRFLQWKWLEAQPMGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKK GPRK7_Hsap FVTSAFYDKFLQWKLFEMQPVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKK GPRK6_Hsap YLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKK GPRK5_Hsap YLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKK GPRK4_Hsap YQESSYFSQFLQWKWLERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKK Gprk2_Dmel FESSMYFHRYLQWKWLEAQPITYKTFRMYRVLGKGGFGEVCACQVRATGKMYACKKLEKK GPRK6_Mmus YLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKK GPRK5_Mmus YLDSMYFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKK GPRK4_Mmus YQESTYFNRFLQWKWLERRPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKK F19C6.1_Cele FAESMYFHRFLQWKWLEKRPVDKHTFRLYRVLGKGGFGEVCACQVRASGKMYALKKLEKK RHOK_Mmus YLESLYFLRFLQWKWLEAQPIGEDWFLDFRVLGKGGFGEVSACQMKATGKMYACKKLNKK GPRK_Spur ------------------------------------------------------------ AqueK008_Aque FVESPFYWRFLQWKTLERMIITKDHFRQYRVLGKGGFGLVFACQSKFTGKMYALKKLEKK RHOK_Hsap RLKKRKGYQGAMVEKKILMKVHSRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNE GPRK7_Hsap RLKKKGGEKMALLEKEILEKVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVG- GPRK6_Hsap RIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMG- GPRK5_Hsap RIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMG- GPRK4_Hsap RIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLG- Gprk2_Dmel RIKKRKGESMVLIEKQILQKINSPFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMG- GPRK6_Mmus RIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMG- GPRK5_Mmus RIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMG- GPRK4_Mmus RIKKRKGEAMALNEKRILEKLHSRFVVSLAYTYETKDALCLVLTIMNGGDLKYHIYNLG- F19C6.1_Cele RVKKRHAETLSLNEKQILQRINSPFVVSLAYAYETKDALCLVLTLMNGGDLKFHLYNLM- RHOK_Mmus RLKKRKGYQGAIVEKRILTKVHSRFIVSLAYAFETKTDLCLVMTIMNGGDVRYHIYNVDE GPRK_Spur --------------------------VSLAYAFEMKEALCLVLTIMNGGDLKFHIHNMG- AqueK008_Aque RVKKRKGEKLALNEKEVLEKVDSRFVVTLAYAYQSKDSLCMVLTLMNGGDLRFHIYSIG- *.***::: * **:*:::*****:::*:: : RHOK_Hsap ENPGFPEPRALFYTAQIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLD GPRK7_Hsap -TRGLDMSRVIFYSAQIACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKG GPRK6_Hsap -QAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPE GPRK5_Hsap -NPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPE GPRK4_Hsap -NPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPE Gprk2_Dmel GEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRISDLGLAVEIPE GPRK6_Mmus -QAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPE GPRK5_Mmus -NPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPE GPRK4_Mmus -DPGFEEPRAVFYAAELCCGLEDLQRKRIVYRDLKPENILLDDHGHIRISDLGLAMEVPE F19C6.1_Cele -PGGFDEKRVQFYAAEITLGLQHLHSERILYRDLKPENILLDDFGHVRISDLGLAVEIKD RHOK_Mmus DNPGFSEPRAIYYTAQIISGLEHLHQRRIVYRDLKPENVLLDNDGNIRISDLGLAVELKE GPRK_Spur -SPGFEEERARFYAAEILCGLEDLHRLRIVYRDMKPENILLDDHGHVRISDLGLAVEIPE AqueK008_Aque -SPGLEPERVVFYAAEIACGLHHLHTARIAYRDMKPDNILLDDAGHIRISDLGLAVHIPE *: *. :*:*:: *: .*: *** **:*:***: *: *:****** .: RHOK_Hsap GQSKTKGYAGTPGFMAPELLQ-GEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKE GPRK7_Hsap GKP-ITQRAGTNGYMAPEILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKED GPRK6_Hsap GQT-IKGRVGTVGYMAPEVVK-NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREE GPRK5_Hsap GDL-IRGRVGTVGYMAPEVLN-NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREE GPRK4_Hsap GQR-VRGRVGTVGYMAPEVVN-NEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEE Gprk2_Dmel GEM-VRGRVGTVGYMAPEVID-NEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKEKVKREE GPRK6_Mmus GQT-IKGRVGTVGYMAPEVVR-NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREE GPRK5_Mmus GDL-IRGRVGTVGYMAPEVLN-NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREE GPRK4_Mmus GEM-VRGRVGTVGYMAPEIIN-HEKYTFSPDWWGLGCLIYEMIAGHSPFRKYKEKVNREE F19C6.1_Cele NEP-IKGRVGTVGYMAPEIVK-NERYSYGVDWWGVGCLIYEMIEGKAPFRQRKEKVKREE RHOK_Mmus GQNKTKGYAGTPGFMAPELLR-GEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKE GPRK_Spur NDT-IRGRVGTVGYMAPEVVK-NERYTFSPDYWGLGCLIYEMIEGRAPFRARKEKVKREE AqueK008_Aque GQS-VRGRVGTPGYMAPEVID-GHRYTFAPDWWGMGCLIYEMICGRTPFRKHKERVSRED .. .** *:****:: * *::..* :***: .: **: :::. :: RHOK_Hsap LKHRIISEPVKY-PDKFSQASKDFCEALLEKDPEKRLGFRD-----ETCDKLRAHPLFKD GPRK7_Hsap LKQRTLQDEVKFQHDNFTEEAKDICRLFLAKKPEQRLGSRE-----K-SDDPRKHHFFKT GPRK6_Hsap VERLVKEVPEEY-SERFSPQARSLCSQLLCKDPAERLGCRG-----GSAREVKEHPLFKK GPRK5_Hsap VDRRVLETEEVY-SHKFSEEAKSICKMLLTKDAKQRLGCQE-----EGAAEVKRHPFFRN GPRK4_Hsap VDQRIKNDTEEY-SEKFSEDAKSICRMLLTKNPSKRLGCRG-----EGAAGVKQHPVFKD Gprk2_Dmel VDRRVKEDPEKY-SSKFNDEAKSMCQQLLAKSIKQRLGCRNG---RMGGQDVMAHPFFHS GPRK6_Mmus VERLVKEVAEEY-TDRFSSQARSLCSQLLSKDPAERLGCRG-----GGAREVKEHPLFKK GPRK5_Mmus VDRRVLETEEVY-SSKFSEEAKSICNMLLTKDSKQRLGCQE-----EGAAEVKRHPFFRN GPRK4_Mmus LERRVKNETEEY-SERFSEDAKSICSMLLIKDPSKRLGCQR-----DGVSAVKQHPIFKD F19C6.1_Cele VERRVREDQEKY-SEKFSEAARTLCRGLLHKEPGFRLGCRRVGRPEDGAEEIRAHPFFNT RHOK_Mmus LKQRIISEPVKY-PEKFSQASKDFCEQLLEKDPEKRLGFRD-----GTCDALRANVLFKD GPRK_Spur VDRRVKEDDEKY-SQKFSTEAQDICKKLLQKDPALRMGFEN-----GTAQTVKDHSFFNS AqueK008_Aque IERRIKDDRVCLDNSAFTEDSRSICDQFLDKVHATRLGCCG-----EMFEDVKAHPFFQT :.: . *. :: :* :* * *:* : .*. RHOK_Hsap ---------LNWRQLEAGMLMPPFIPDSKTVYAKDIQDVGAFSTVKGVAFDKTDTEFFQE GPRK7_Hsap ---------INFPRLEAGLIEPPFVPDPSVVYAKDIAEIDDFSEVRGVEFDDKDKQFFKN GPRK6_Hsap ---------LNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVELEPTDQDFYQK GPRK5_Hsap ---------MNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSK GPRK4_Hsap ---------INFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTADEDFYAR Gprk2_Dmel T-------QLNWRRLEAGMLEPPFVPDPHAVYAKDVLDIEQFSTVKGVNIDESDTNFYTK GPRK6_Mmus ---------LNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVDLEPTDQDFYQK GPRK5_Mmus ---------MNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSK GPRK4_Mmus ---------INFSRLEANMLDPPFIPDPQAIYCRNILDIGQFSVVKGVNLDTNDEIFYAE F19C6.1_Cele ADTVTGREPVPWKKMEAGKVTPPFCPDPRAVYAKDVLDIEQFSTVKGVRLDATDTQFYGK RHOK_Mmus ---------ISWRQLEAGMLIPPFIPDSRTVYAKNIQDVGAFSTVKGVVFDKADTEFFQE GPRK_Spur ---------ISFSRLEAGKLDPPFEPDKRAVYAKDVLDIEQFSTVKGVNLDQNDDRFYTK AqueK008_Aque ---------IDFAHLEAGLIPPPFIPNSRAVYAKDVLDIDQFSSVRGVEIEKADEDFADK : : :: *. : *** *: .:*.::: :: ** *:*: :: * * . RHOK_Hsap FATGNCPIPWQEEMIETGIFGELNVWRS-DGQMPDDMKG-----ISG------------- GPRK7_Hsap FATGAVPIAWQEEIIETGLFEELNDPNR----------P-----TGC------------- GPRK6_Hsap FATGSVPIPWQNEMVETECFQELNVFGL-DGSVPPDLDW----KG-QPPAPPKKGLLQRL GPRK5_Hsap FSTGSVSIPWQNEMIETECFKELNVFGP-NGTLPPDLNR-----N-HPPEPPKKGLLQRL GPRK4_Hsap FATGCVSIPWQNEMIESGCFKDINKSES-EEALPLDLDK----NIHTPVSRPNRGFFYRL Gprk2_Dmel FNTGSVSISWQNEMMETECFRELNVFGP-EECPTPDLQI------NAAPEPDKAGCFP-- GPRK6_Mmus FATGSVSIPWQNEMVETECFQELNVFGL-DGSVPPDLDW----KG-QPTAPPKKGLLQRL GPRK5_Mmus FSTGSVPIPWQNEMIETECFKELNVFGP-NGTLSPDLNR-----S-QPPEPPKKGLFHRL GPRK4_Mmus FATGSVTIPWQNEMIESGCFKDLNENED-DLSSLEKYK-----MC-SSILRPKRNFFRRL F19C6.1_Cele FNTGCVSIPWQSEMIETECFAELNTFHDEDGNVMWNLRPDGINMDERRNGTSKPGFFSRL RHOK_Mmus FASGNCSIPWQEEMIETGLFGDLNVWRA-DGQMPDDMKG-----ITT------------- GPRK_Spur FNSGSVAIPWQMEMIETQVFLELNVFGP-NGTLTADLMP------DLPPPPPKQGFFRRI AqueK008_Aque FATGIVPKPWQEEVSS-------------------------------------------- * :* . .** *: . RHOK_Hsap --------G-----------------------------SSSSSKSGMCLVS GPRK7_Hsap --------E-----------------------------EGNSSKSGVCLLL GPRK6_Hsap FSRQRIAVETA------------ATARKSS--PP---ASSPQPEAPTSSWR GPRK5_Hsap FKRQHQNNSKS------------SPSSKTS--FN-HHINSNHVSSNSTGSS GPRK4_Hsap FRRGGCLTM--------------VPSE----------------KEVEPKQC Gprk2_Dmel FRRKKKQPART------------QPI----PIPE-HLLTTSHSVSSTTVES GPRK6_Mmus FSRQRIAVGTA------------ATVRKSS--PP---ASSPQAEAPTGGWR GPRK5_Mmus FRRQHQSNSKS------------SPTPKTS--CN-HRINSNHINSNSTGSS GPRK4_Mmus FRRTGCLNI--------------AL-S----------------EEREPTEH F19C6.1_Cele FRKKNIEVTKSLHDLSHLGVEQQQPPKTSTQTPA-VRSSRAASASGRTLVI RHOK_Mmus --------EE----------------------------AAPTAKSGMCLIS GPRK_Spur FRIKDIKEKDG-----------KNKSTKGLQSEKIFEYRKSKEIYGVHNTP AqueK008_Aque --------------------------------------------------T