CLUSTAL W (1.83) multiple sequence alignment IRAK-14_d-2_Smoe MA--------GCLFFAIR-----KRKMK-------LID--VVAFSAN------------- IRAK-14_b-2_Smoe MA--------IEMAS-SRSGSSTRARMRALWVAVGLVELW-LWLTSTAHAQFVPKDNILL IRAK-14_a-2_Smoe M----------------------------------------------------------- IRAK-14_e_Smoe MRVTGTRILAAQMRI-DRGNRPISRPDHPLFFFI-VLASF-LALLGRSSAQWKPQDVFRI IRAK-14_a-1_Smoe MA--------ARSRL------------------A-LLGLWTVAFLARCLAQWQPRDFYRI IRAK-14_b-1_Smoe MA--------IEMASSSRSGSSTRARMRALWVAVGLVELW-LWLTSTAHAQFVPKDNILL IRAK-14_d-1_Smoe ------------------------------------------------------------ IRAK-14_d-2_Smoe -------------------SQL-------------------------------------- IRAK-14_b-2_Smoe ACGAAGST-NVSGRTFVADSSFAQGGAPRSGSIPTSSAANLSSADEQRLYSTARVFTPKG IRAK-14_a-2_Smoe ------------------------------------------------------------ IRAK-14_e_Smoe SCGESRSDIDGNGLEWTPDAE---NPRLVAGGTPTNSTRG--TSGTSVPYRAARVFTSPA IRAK-14_a-1_Smoe DCGAASNT-SSGDRHWQGEPP--QSPAFASSGISINTSAQNPELPSPAPYLTARIFTARA IRAK-14_b-1_Smoe ACGAAGST-NVSGRTFVADSSFAQGGAPRSGSIPTSSAANLSSADEQRLYSTARVFTAKG IRAK-14_d-1_Smoe ------------------------------------------------------------ IRAK-14_d-2_Smoe ------------------------------------------------------KA---- IRAK-14_b-2_Smoe SFSIGDLTPGRHWIRLHFLPFS-P--DLAAALFSVSADEYLLLSSQSVAGEIQAQARSIS IRAK-14_a-2_Smoe ------------------------------------------------------------ IRAK-14_e_Smoe SYSF-SISPGRHWVRLHFAPLA-D--ASSRARFSVAIGSRLLVANSSIAEDIAAG--NGS IRAK-14_a-1_Smoe NYSF-PVDPGRHWIRLHFYPFPSPGFDPALANFSITVGPYTLFSGGIVDSVRRSG--SGG IRAK-14_b-1_Smoe SFSIGDLTPGRHWIRLHFLPFS-P--DLAAALFSVSADEYLLLSSQSVAGEIQAQARSIS IRAK-14_d-1_Smoe ------------------------------------------------------------ IRAK-14_d-2_Smoe ---------------------TPQ------------------------------------ IRAK-14_b-2_Smoe SPALLKEYSINITTAQLTISLVPSP---GSLAFVNAIEIVSIPDAAIQDDGQLVG-QGTQ IRAK-14_a-2_Smoe ------------------------------------------------------------ IRAK-14_e_Smoe -SPVVREFTIHTSGTAVAVTLTPSA---SFIAFVSGIELISMARDALSPSVVEISPEASE IRAK-14_a-1_Smoe -VYLVKEYSVVAEGSELAIVFQPSPSSNGSFALINGIEVMSMPEDALQDDAVLLG-QGTA IRAK-14_b-1_Smoe SPALLKEYSINITTAQLTISLVPSP---GSLAFVNAIEIVSIPDAAIQDDGQLVG-QGTQ IRAK-14_d-1_Smoe ------------------------------------------------------------ IRAK-14_d-2_Smoe ------------------------------------------------------------ IRAK-14_b-2_Smoe A-FLGMARAALQTMYRLNVGGESIDPSLDSG-LSRRWIRDN-PFLVGAREGIPAPK-IED IRAK-14_a-2_Smoe ------------------------------------------------------------ IRAK-14_e_Smoe SRQVEIAGILARTLYRLNVGGDLIAPGNDSSSQARTWLPDE-PFLQGVARGVPVPPAVPD IRAK-14_a-1_Smoe T-KFGFSRLALETLYRLNVGGASVNAANDT--QQRSWVSDGHGFIEGAAAGVGSQDFSSS IRAK-14_b-1_Smoe A-FLGMARAALQTMYRLNVGGESIDPSLDSG-LSRRWIRDN-PFLVGAREGIPAPK-IED IRAK-14_d-1_Smoe ------------------------------------------------------------ IRAK-14_d-2_Smoe ------------------------------------------------------------ IRAK-14_b-2_Smoe ITYPPLLPGFIAPKSVYGTSRTMGVSDLINT---------------------------HT IRAK-14_a-2_Smoe ------------------------------------------------------------ IRAK-14_e_Smoe IVYPATVPEYIAPRGVYGTARSLGGSNTVTNAFNISWAFSVAPGYAHYVRLHFAELVYSS IRAK-14_a-1_Smoe IKFTKEVPEFIAPAAVYGTGRVLGISNTVSNTFKISWSFPVSPGYSHLVRLHFAELYYTK IRAK-14_b-1_Smoe ITYPPLLPGFIAPKSVYGTARTMGVSDLINTQFNLTWTFAVDSGYSYFVRMHFCETVYST IRAK-14_d-1_Smoe ------------------------------------------------------------ IRAK-14_d-2_Smoe --------------------------CKKGLLFLSFIVF--------------------- IRAK-14_b-2_Smoe PYARIFDVFINRLPAVKGLDVVVKANGAQTAMFMDFVVPMNDGGSSMVVELGPSPGNGAQ IRAK-14_a-2_Smoe ------------------------------------------------------------ IRAK-14_e_Smoe PMQRIFSVYINNRTAIRALDLIQQTGAANTPYYRDFLVLPVDGLANLRLQVGPLTGSNSQ IRAK-14_a-1_Smoe TYQRMFNVYINNRTAIDGLDLIVL-GPRFTPVYKDFVVIPSSGVRSLRVQIGPAPNSNAQ IRAK-14_b-1_Smoe PYARIFDVFINRLPAVKGLDVVVKANGAQTAMFMDFVVPMNDGGSSMVVELGPSPGNGAQ IRAK-14_d-1_Smoe ------------------------------------------------------------ IRAK-14_d-2_Smoe ----------------------------GADI---------------------------- IRAK-14_b-2_Smoe HNDSILSGIEIFKVNNTRGSLAGSLIPPGVDLSKDDGSSGGSTGIGAAGIGGAVAGGLLV IRAK-14_a-2_Smoe --------------NSTAGNLSDSD--GGESSSSSSGRSGGSKGVGA--IVGAAVGGIAL IRAK-14_e_Smoe VQDAILNGVEIFRLNDSSGSVDGLA---VVPRSSDSGGNGGH-HLGV--IIGCVAGGVFA IRAK-14_a-1_Smoe FNDAILNGLEIFKMNSTAGSLSDSD--GGESSSSSSGRSGGSKAVGA--IVGAAVGGIAL IRAK-14_b-1_Smoe HNDSILSGIEIFKVNNTRGSLAGSLIPPGVDLSKDDGSSGGSTGIGAAGIGGAVAGGLLV IRAK-14_d-1_Smoe ------------------------------------------------------------ IRAK-14_d-2_Smoe ------------------------------------------------------------ IRAK-14_b-2_Smoe IGLLGAGLCFVRRRRHPGLAKGKSKKKKSASWLPLHAAGNGN---------STSIASKFS IRAK-14_a-2_Smoe LALLAA--CVFVL-----CCRRGAKGGKKLGWRPVPASQAGT---------GTS---TVT IRAK-14_e_Smoe LVAIALAICFFFR-----CCKGGGKKPSTSSWQAL---GNGHPHHHHHAFSLTTLGSTMG IRAK-14_a-1_Smoe LALLAA--CVFVL-----CCRRGAKGGKKLGWRPVPASQAGT---------GTS---TVT IRAK-14_b-1_Smoe IGLLGAGLCFVRRRRHPGLAKGKSKKKKSASWLPLHAAGNGN---------STSIASKFS IRAK-14_d-1_Smoe ------------------------------------------------------------ IRAK-14_d-2_Smoe ----RPADVTTIA---KDAKDSNHIRRLTLKEVVNATNCYK--TMIGEGGFGTVFYGTLS IRAK-14_b-2_Smoe TGGASNKSGATVA---STATSSLGGRFFTFAEILEATNNFDETLLLGVGGFGKVYRGELF IRAK-14_a-2_Smoe -LGFPGSSPATHYSVT----PANSCKHFSLQQIVDATDGFDDDLLLGVGGFGKVYKGEIN IRAK-14_e_Smoe -AGSPRSAAGSYYNAGSAASAGGHGRYFTLQEIAEATNSFDETRLLGVGGFGRVYKGEID IRAK-14_a-1_Smoe -LGFPGSSPATHYSAT----PANSCKHFSLQQIVDATDGFDNDLLLGVGGFGKVYKGEIN IRAK-14_b-1_Smoe TGGASNKSGATVA---STATSSLGGRFFTFAEILEATNNFDETLLLGVGGFGKVYRGELF IRAK-14_d-1_Smoe ------------------------------------------------------------ IRAK-14_d-2_Smoe -GQ-AVAVKARSSSSIQGTREFNTELNLLSRIQHENLVPLLGFCAEDEQEILIYPYMPNG IRAK-14_b-2_Smoe DGT-KVAVKRGNPRSEQGLTEFQTEIEMLSKLRHLHLVSLIGYCEEHCEMILVYECMANG IRAK-14_a-2_Smoe GGT-KVAVKRGNPMSEQGMTEFQTEIEMLSKLRHRHLVSLIGYCDENSEMILVYDYMANG IRAK-14_e_Smoe NGTLEVAVKRGNPRSEQGIAEFQAEIGLLSKLRHRHLVSLIGYCDEQSEMILVYEYMARG IRAK-14_a-1_Smoe GGT-KVAVKRGNPMSEQGMTEFQTEIEMLSKLRHRHLVSLIGYCDENSEMILVYDYMANG IRAK-14_b-1_Smoe DGT-KVAVKRGNPRSEQGLTEFQTEIEMLSKLRHLHLVSLIGYCEEHCEMILVYECMANG IRAK-14_d-1_Smoe --------------------------------------------------------MGGG * * IRAK-14_d-2_Smoe SLQDRLYGEGFKRKPLDWPTRLSIALGAAKGLSFLHAGGDL-SIIHRDIKSSNILLDQSM IRAK-14_b-2_Smoe TLRAHLYGS--DLPPLSWKQRLEICIGAARGLHYLHTGAEQGTIIHRDVKTTNILLDENF IRAK-14_a-2_Smoe PLRGHLYGS--DAPTLSWKQRLEICIGAARGLHYLHTGAQR-AIIHRDVKTTNILLDEKF IRAK-14_e_Smoe PLRGHLYGTE-DLQPLPWRHRLEILVGAARGLHYLHTGA---AIIHRDVKTTNILLDEHL IRAK-14_a-1_Smoe PLRGHLYGS--DAPTLSWKQRLEICIGAARGLHYLHTGAQR-AIIHRDVKTTNILLDEKF IRAK-14_b-1_Smoe TLRAHLYGS--DLPPLSWKQRLEICIGAARGLHYLHTGAEQGTIIHRDVKTTNILLDENF IRAK-14_d-1_Smoe TLMEHLYGS--KS-PLDWKARVKIAVGAATALDYLHNGSDS-KIIHRDVKSTNILLDSGM .* :*** . .* * *:.* :*** .* :** *. *****:*::*****. : IRAK-14_d-2_Smoe TAKVADFGFSKFAPQDGDSVVSLEVRGTAGYLDPEYYLTQELTVKSDVYSFGVVLLEVIC IRAK-14_b-2_Smoe VAKVSDFGLSKTGPSLDRTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVLFEVLC IRAK-14_a-2_Smoe VAKVSDFGLSKVGPSLDHTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVLMEVVC IRAK-14_e_Smoe VAKVSDFGLSKTGPMLDQTHVSTAVKGSFGYLDPEYFRRQQLTDKSDVYSFGVVMVEVMC IRAK-14_a-1_Smoe VAKVSDFGLSKVGPSLDHTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVLMEVVC IRAK-14_b-1_Smoe VAKVSDFGLSKTGPSLDRTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVLFEVLC IRAK-14_d-1_Smoe NAKVADFGLSKHVTRIDATHVTTLVKGTVGYLDPEYYASNQLTEKSDVYSFGVVLLELIC ***:***:** . . : *: *:*: *******: ::** **********:.*::* IRAK-14_d-2_Smoe GREPLSIDRPRSEWSLVEWARPYIQDTNIEAIVDSSISSSYSP-----EAMWRVLEVAML IRAK-14_b-2_Smoe ARPAINPALPREQVNIAEWAMQYQRMGALEQIVDANLKGQCSQ-----ESLQKFGETAEK IRAK-14_a-2_Smoe ARPAINPALPRDQVSIAEWALHWQKLGRLSNIMDPRLAGDCTP-----ESLQKFGEIAER IRAK-14_e_Smoe ARPAIDPALPREQVNIAEWAMSAQRSGRLEEILDPTLRRPGSDEDADMASVRKVGETADK IRAK-14_a-1_Smoe ARPAINPALPRDQVSIAEWALHWQKLGRLSNIMDPRLAGDCTP-----ESLQKFGEIAER IRAK-14_b-1_Smoe ARPAINPALPREQVNIAEWAMQYQRMGALEQIVDANLKGQCSQ-----ESLQKFGETAEK IRAK-14_d-1_Smoe GREPLSDRVPADQYSIITWARPYLLSGSYNEVVDRNIAGRFSI-----GSMAIFANVAAK .* .:. * .: .: ** . ::* : : :: . : * IRAK-14_d-2_Smoe SVQPHSSRRPSMSDIVRELEDALIIENNASQFMA-S-IDS-------------------- IRAK-14_b-2_Smoe CLAEQGIDRPAMGDVLWNLEYALQLQEASSGDSSGMILDHSATRAGDQMEVPLRS--SAD IRAK-14_a-2_Smoe CLADRGSERPSIGDVLWNLEYSLQLHDAAMFHHHQRSEDGNSNLARPTPEIPRT---SSD IRAK-14_e_Smoe CLQENGVQRPSMGDVLWNLESALHIQEAAQRRFGRE-NGGGGGDAGGGVAAPAAGAVENG IRAK-14_a-1_Smoe CLADRGSERPSIGDVLWNLEYSLQLHDAAMFHHHQRSEDGNSNLARQTPEIPRT---SSD IRAK-14_b-1_Smoe CLAEQGIDRPAMGDVLWNLEYALQLQEASSGDSSGMILDHSATRAGDQMEVPLRS--SAD IRAK-14_d-1_Smoe SVARDPNERPKMSQVLRDLKEAQAFETA-------------------------------- .: ** :.::: :*: : :. IRAK-14_d-2_Smoe ---------NPSGLSKQFDISPAFSETMGSPDPR IRAK-14_b-2_Smoe HQADYHRRLGSEDDFEDASASAVFSQ-LVNPQGR IRAK-14_a-2_Smoe SQ--RTMMSFEENHSGDTTASVVFSQ-LVHPEGR IRAK-14_e_Smoe GA-TSITDDYYDGYSEDASASAVFSQ-LVNPQGR IRAK-14_a-1_Smoe GQ--RMMMSFEENHSEDTTASVVFSQ-LVHPEGR IRAK-14_b-1_Smoe HQADYHRRLGSEDDFEDASASAVFSQ-LVNPQGR IRAK-14_d-1_Smoe ---------------------------------M