CLUSTAL W (1.83) multiple sequence alignment IRAKb_e_Smoe MDRNNE------------------------------------------------------ IRAKb_b-2_Smoe MFKALK------------------------------------------------------ IRAKb_c-2_Smoe MLMSSTHCRF-------------------------------------------------- IRAKb_h_Smoe MLRKASSKLD-------------------------------------------------- IRAKb_b-1_Smoe MFKARR------------------------------------------------------ IRAKb_d_Smoe MAYLQ------------------------------------------------------- IRAKb_g-1_Smoe SVRQ-------------------------------------------------------- IRAKb_j_Smoe MRRDESSLRM-------------------------------------------------- IRAKb_c-1_Smoe LSST--HCRF-------------------------------------------------- IRAKb_f_Smoe MDSSSKPMNGSAGGSPVGDERKMGDHEHEFRISIILLRSFLLVLVIISEALMVTDRETGS IRAKb_g-2_Smoe ------------------------------------------------------------ IRAKb_e_Smoe ------------------------------------------------------------ IRAKb_b-2_Smoe ------------------------------------------------------------ IRAKb_c-2_Smoe --MK-------------------------------------------------------- IRAKb_h_Smoe --LA-------------------------------------------------------- IRAKb_b-1_Smoe ------------------------------------------------------------ IRAKb_d_Smoe ------------------------------------------------------------ IRAKb_g-1_Smoe ------------------------------------------------------------ IRAKb_j_Smoe ------------------------------------------------------------ IRAKb_c-1_Smoe --MK-------------------------------------------------------- IRAKb_f_Smoe VPLPFFGLPRPVFVTKTAKYELVTGLKFYVDALGVVIGYTVLHLLFNIGLVATKGTVVDC IRAKb_g-2_Smoe ------------------------------------------------------------ IRAKb_e_Smoe ------------------------------------------------------------ IRAKb_b-2_Smoe ------------------------------------------------------------ IRAKb_c-2_Smoe -------------------------KEVTYIN---------------------------- IRAKb_h_Smoe ------------------------------------------------------------ IRAKb_b-1_Smoe ------------------------------------------------------------ IRAKb_d_Smoe ------------------------------------------------------------ IRAKb_g-1_Smoe ------------------------------------------------------------ IRAKb_j_Smoe ------------------------------------------------------------ IRAKb_c-1_Smoe -------------------------KEVTYIN---------------------------- IRAKb_f_Smoe KSVAWISFIADSMMGYLLLSSAAVATEIGYLAEEGAPAVLWRKVCNAFGYFCTVYAISVV IRAKb_g-2_Smoe ------------------------------------------------------------ IRAKb_e_Smoe ------------------------------------------------------------ IRAKb_b-2_Smoe ------------------------------------------------------------ IRAKb_c-2_Smoe -----------------------------------------------------------E IRAKb_h_Smoe ------------------------------------------------------------ IRAKb_b-1_Smoe ------------------------------------------------------------ IRAKb_d_Smoe ------------------------------------------------------------ IRAKb_g-1_Smoe ------------------------------------------------------------ IRAKb_j_Smoe ------------------------------------------------------------ IRAKb_c-1_Smoe -----------------------------------------------------------E IRAKb_f_Smoe ICFIAALVSFVVVGISAYHLFRLYGIQQQAAREKEKLSAEIYEAPRSFQRVEAMQPLLDE IRAKb_g-2_Smoe ------------------------------------------------------------ IRAKb_e_Smoe ---------------------------------------------------------GNL IRAKb_b-2_Smoe ---------------------------------------------------------GGT IRAKb_c-2_Smoe LL-------------------------------------------ECNLAVMDKHGKGRV IRAKb_h_Smoe ------------------------------RPPGGGA----------------------- IRAKb_b-1_Smoe ---------------------------------------------------------GGT IRAKb_d_Smoe ------------------------------------------------------------ IRAKb_g-1_Smoe ------------------------------------------------------------ IRAKb_j_Smoe ---------------------------------------------------------GFL IRAKb_c-1_Smoe LL-------------------------------------------ECNLAVMDKHGKGRV IRAKb_f_Smoe ALDPNKELWLLRLPDLDLEELSNTSWRLKLEAADGNMGHLVCNGVKYSFQRHDIQGSSKY IRAKb_g-2_Smoe ------------------------------------------------------------ IRAKb_e_Smoe LKV-----------------------------------SESVVLN--P------------ IRAKb_b-2_Smoe SN---------------------------N--------SVTVDPG--P------------ IRAKb_c-2_Smoe VKLVTPDKCDVDSSDLFELEVPL-GLTSMDSCTD---HKRKVNSS--P------------ IRAKb_h_Smoe ----ARHRLDFDRPKPFPMSFGLMG-----AAVGDKAKT--KKIAPS------------- IRAKb_b-1_Smoe SN---------------------------N--------SVTVDPG--P------------ IRAKb_d_Smoe ------------------------------------------------------------ IRAKb_g-1_Smoe ------------------------------------------------------------ IRAKb_j_Smoe ----------------------------------------S------------------- IRAKb_c-1_Smoe VKLVTPDKCDVDSSDLFELEVPL-GLTSMDSCTD---HKRKVDSS--P------------ IRAKb_f_Smoe AYVPTQDKIEVRP---VPVEVSI-VR-SVEPTIAHPVAAENVDAAPNPAEGNFRVLRFLS IRAKb_g-2_Smoe ------------------------------------------------------------ IRAKb_e_Smoe ------------------------------------------------------------ IRAKb_b-2_Smoe ------------------------------------------------------------ IRAKb_c-2_Smoe ------------------------------------------------------------ IRAKb_h_Smoe ------------------------------------------------------------ IRAKb_b-1_Smoe ------------------------------------------------------------ IRAKb_d_Smoe ------------------------------------------------------------ IRAKb_g-1_Smoe ------------------------------------------------------------ IRAKb_j_Smoe ------------------------------------------------------------ IRAKb_c-1_Smoe ------------------------------------------------------------ IRAKb_f_Smoe RLGKMVMIRLYQYAGLTIGTYFALTYYIAHKDWVRELKYTREEQIEKARQLRQEKKRMRE IRAKb_g-2_Smoe ------------------------------------------------------------ IRAKb_e_Smoe ------------------------------------------------------------ IRAKb_b-2_Smoe ------------------------------------------------------------ IRAKb_c-2_Smoe ------------------------------------------------------------ IRAKb_h_Smoe --SRSNLIARPESFR-----------QLAAEVIVVAIDGSKSITRHALEWALSN-VVQPG IRAKb_b-1_Smoe ------------------------------------------------------------ IRAKb_d_Smoe ------------------------------------------------------------ IRAKb_g-1_Smoe ------------------------------------------------------------ IRAKb_j_Smoe ------------------------------------------------------------ IRAKb_c-1_Smoe ------------------------------------------------------------ IRAKb_f_Smoe EQLRTNPILREEQERSAEEWKESSDEESQREVVLVAVDASKKMTDYALNWALANVVVHPG IRAKb_g-2_Smoe ------------------------------------------------------------ IRAKb_e_Smoe ----------------------------------SLQLSSDVSS-------D-------- IRAKb_b-2_Smoe ----------------------------------SENAAVELDA-------VLPTELDET IRAKb_c-2_Smoe ----------------------------------ENNNANQRSATSANAPAVSGEATDNT IRAKb_h_Smoe DRIILLALLPSSSGK-----RWKFWKFAKFARDS--------ST-------KDKIRQEET IRAKb_b-1_Smoe ----------------------------------SENAAVELDA-------VLPRELDET IRAKb_d_Smoe -------------------------------------------A-------F-------- IRAKb_g-1_Smoe ------------------------------------------------------------ IRAKb_j_Smoe -------------------------------------------L-------L-----R-- IRAKb_c-1_Smoe ----------------------------------ENNNANQRSAASANAPAVSGEATDST IRAKb_f_Smoe DRIVFQAIAPASSTSNSSDSVWKSWGFPALGGECAAAAAASLKA-------TRKEELEEI IRAKb_g-2_Smoe ------------------------------------------------------------ IRAKb_e_Smoe ------------------------------------------------------------ IRAKb_b-2_Smoe NTAI-------------------------------------------------------- IRAKb_c-2_Smoe TFASELVKCKLLLAILSIMF-LTV------------------------------------ IRAKb_h_Smoe RK-----SCQCMMEQLQSLFDAKKVQTTVKIYPSAEKGATTIEAKKLQATWVVLDRHLKK IRAKb_b-1_Smoe NTAI-------------------------------------------------------- IRAKb_d_Smoe ------------------------------------------------------------ IRAKb_g-1_Smoe ------------------------------------------------------------ IRAKb_j_Smoe ------------------------------------------------------------ IRAKb_c-1_Smoe TFASELVKCKLLLAILSIMF-LTV------------------------------------ IRAKb_f_Smoe RN-----KCSMVMEKLRKIHDLKKVHTTLEILQFARRGVIPSEAKRFRATWVVLDRNLKS IRAKb_g-2_Smoe ------------------------------------------------------------ IRAKb_e_Smoe ------------------------------------------------------------ IRAKb_b-2_Smoe ------------------------------------------------------------ IRAKb_c-2_Smoe ------------------------------------------------------------ IRAKb_h_Smoe EEKRCSDNLQCNLVIVDRYNPKILRLNLKQSPEATPLEKAAVPPPLAK--QAETPASSPD IRAKb_b-1_Smoe ------------------------------------------------------------ IRAKb_d_Smoe ------------------------------------------------------------ IRAKb_g-1_Smoe ------------------------------------------------------------ IRAKb_j_Smoe ------------------------------------------------------------ IRAKb_c-1_Smoe ------------------------------------------------------------ IRAKb_f_Smoe EGKLCLQELNSNIVVVHRSNPKILRLNLKRR---------DL--PYDEEESID-SSSVLL IRAKb_g-2_Smoe ------------------------------------------------------------ IRAKb_e_Smoe ------------------------------------------------------------ IRAKb_b-2_Smoe ------------------------------------------------------------ IRAKb_c-2_Smoe ------------------DYTANGQVSTIDSGFTAEESASLGS--FRCFLKLSPDKNSP- IRAKb_h_Smoe VGTPFTSTSRGN-SSCSESSTSPFSGTEPGSYQTTT---------PESFGVTIEDVRRPE IRAKb_b-1_Smoe ------------------------------------------------------------ IRAKb_d_Smoe ------------------------------------------------------------ IRAKb_g-1_Smoe ------------------------------------------------------------ IRAKb_j_Smoe ---------------------------SRKSGFV-----------------LEGD----- IRAKb_c-1_Smoe ------------------DYTANGQVSTTDSGFIAEESAALGSRSFRCFLKLSPDKNSP- IRAKb_f_Smoe NGLSLSVMPKGFDQLYWESSTSSSEASSPDSRLVTAPKFELSV--LEELLKNETRRKGPS IRAKb_g-2_Smoe ------------------------------------------------------------ IRAKb_e_Smoe ---------SPNEGSVSSHKA---------------------------------LAERQQ IRAKb_b-2_Smoe ------------------------------------------------------------ IRAKb_c-2_Smoe QGSIEAVSDRPSSGTGPISVQPDRRSEML--ELLGGPNELETKLF------DSYVEESSM IRAKb_h_Smoe YGASESDSDDPTVVPRRWRNSSRNLSTKDHSKNK------EYKEARQAEGTSTCVSLSDL IRAKb_b-1_Smoe ------------------------------------------------------------ IRAKb_d_Smoe ------------------------------------------------------------ IRAKb_g-1_Smoe ------------------------------------------------------------ IRAKb_j_Smoe -----ESSSAR------------------------------------------------- IRAKb_c-1_Smoe QGSIEAVSDRPSCGMVPISVQPDRRSEML--ELLGGPNELETKLF------DSYVEESSM IRAKb_f_Smoe -PS-EVLN---STTSSPASHKPQVLNDFL--RMK------ESREYTEE--T---DT---- IRAKb_g-2_Smoe ------------------------------------------------------------ IRAKb_e_Smoe IIALELESKQQHGPETE-------------------TREVTHSDPAPPVCLICESQKR-- IRAKb_b-2_Smoe ----KLDKEKLTTDEAITED--------------TI-LFPKPGSSALPLCSVCKHKPRD- IRAKb_c-2_Smoe LLGSKLHQEAGGNEEAFVKNVVSDLDRCFSVVENHEAKGASGNQGAAPLCHLCNNKSPR- IRAKb_h_Smoe LTSCKLSSEL------DERNNRPNCEEATSIRRAVSLT-THSPLEPPPLCSICQHKAPV- IRAKb_b-1_Smoe ----KLDKEKLTTDEAITED--------------TI-LFPKPGSSALPLCSICKHKPRD- IRAKb_d_Smoe -------------------------------------TPVFSQQDFDKRCSGCYCKTRN- IRAKb_g-1_Smoe ---------------------------------AVALPLKRSLAGSPPLCSICQHASPV- IRAKb_j_Smoe --------------------------------SSGSVAPSTELEGAAYVCSACKTRSFRS IRAKb_c-1_Smoe LLGSKLHQEAGGNEEAFLKDVVSDLDRCFSVVENHEAKGASGNQGAAPLCHLCNNKSPR- IRAKb_f_Smoe -----------------QRNVSRPVDRVSSVRKQIHL-RKQSSPQPPPLCSICQHKTPV- IRAKb_g-2_Smoe ---------------------------------AVALPLKRSLAGSPPLCSICQHASPV- * * IRAKb_e_Smoe -FRTTTNFTYAELEEATLNFSPGNFLAEGGYGPVYRGIL-KDGRYIAVKRNKDASTQGEK IRAKb_b-2_Smoe FKRQTREFTYSELEEATDNFSHANFLAEGGFGFVYKGVL-KGGQHIAVKQHKLASTQGGR IRAKb_c-2_Smoe FGTQPIMFSFSKIEEATNKFSKENLVAEGGFGFVYKGVL-SDGQLVAVKQHKLASRQGDR IRAKb_h_Smoe FGRPPREFTFEELELATGGFSQANFLAEGGFGSVHRGVL-PEGQVVAVKQHKLASSQGDV IRAKb_b-1_Smoe FKRQTREFTYSELEEATDNFSHANFLAEGGFGFVYKGVL-KGGQHIAVKQHKLASTQGGR IRAKb_d_Smoe -AQEIREFKLAEIEEATHSFSQANFLSEGGFGNVFKGILLEQGLEVAVKRHKLKSTQGDK IRAKb_g-1_Smoe FGRPPRRFSYSELEFATGGFCKANFLAEGGYGSVHRGVL-GDGIPVAVKQYKLASSQGDL IRAKb_j_Smoe SGRPLKVFFSDELKAATNDFGFCNYMADAEGGHVFRGVL-EGGEVVAVRVISDASV---- IRAKb_c-1_Smoe FGTQPIVFSFSKIEEATNKFSKENLVAEGGFGFVYKGVL-SDGQLVAVKQHKLASRQGDR IRAKb_f_Smoe FGKPPRKFTFAELQLATGGFSDVNFLAEGGYGSVYRGRL-PDGQAVAVKQHKLASTQGDK IRAKb_g-2_Smoe FGRPPRRFSYSELEFATGGFCNANFLAEGGYGSVHRGVL-GDGIPVAVKQYKLASSQGDL * ::: ** * * :::. * *.:* * * :**: . * IRAKb_e_Smoe EFKAEVEALSGAQHRNLVTLLGFCIEG-GKRILVYEFVCNKCLDWHLSAANT--NVLPWS IRAKb_b-2_Smoe EFCAEVKVLSGAQHRNLVTLLGFCVED-GKRMLVYEFVCNKSLDYHLFDKN---TVLPWC IRAKb_c-2_Smoe EFKAEVEVLSSAQHRNLVTLIGYCTEG-GRRILVYEFVCNGSLNKHLSRKNP--KPLDWP IRAKb_h_Smoe EFCSEVEVLSCAQHRNVVMLIGYCMED-SRRLLVYEFICNNSLDAHLYGKTM--DPLEWK IRAKb_b-1_Smoe EFCAEVKVLSGAQHRNLVTLLGFCVEG-GKRMLVYEFVCNKSLDYHLFDKN---TVLPWC IRAKb_d_Smoe EFFAEIKVLSHTNHDNVVSLVGYCTEN-GQRILVYEYVCNGTLAWHLSAKNS--TVLSWP IRAKb_g-1_Smoe EFCSEVEVLSCAQHRNVVMLIGYCIER-KRRLLVYEFICNGSLDSHIYGVTK--PPLKWS IRAKb_j_Smoe -FQSRKQLLGRIRSPNIVRLVGYCDEGDDRKFLVYDFICNGSLEWHLTVLTR--NAMGWS IRAKb_c-1_Smoe EFKAEVEVLSSAQHRNLVTLIGYCTEG-GRRILVYEFVCNGSLNKHLSRKNP--KPLDWP IRAKb_f_Smoe EFCAEVEVLSCAQQRNLVMLIGYCAED-KKRLLVYEFVCNGSLDSHLYGRRSKTVTLEWP IRAKb_g-2_Smoe EFCSEVEVLSCAQHRNVVMLIGYCIER-KRRLLVYEFICNGSLDSHIYGVTK--PPLKWS * :. : *. . *:* *:*:* * :::***:::** * *: : * IRAKb_e_Smoe ARHAVAVGAARALRYLHEGCRTGSIVHRDVRPHNILLTHDYTPKVGDF------GLARWQ IRAKb_b-2_Smoe ARQGIALGAARAMRYLHEECRVGTIIHRDLRPHNILLTHDYAPMVGDF------GLARWN IRAKb_c-2_Smoe SRQNIALGAARGLRYLHEECRIGCIVHRDVRPNNILVTHDFTALVGDF------GLARWQ IRAKb_h_Smoe YRQRVAIGAARGLRYLHEECRVGCIVHRDMRPNNILLTHDYEPMVGDF------GLARWQ IRAKb_b-1_Smoe ARQGVALGAARAMRYLHEECRVGTIIHRDLRPHNILLTHDYAPMVGDF------GLARWH IRAKb_d_Smoe ARHSIAVGIAKALRYLHHECTQGRVIHRDIRPHNILLRHDFTPVVGDF------GLAKWE IRAKb_g-1_Smoe SRHKIAVGAARGLRYLHEECRVGCIVHRDMRPNNILLTHDFEPMVGDF------GLARWQ IRAKb_j_Smoe IRKSIAVGIAKGLLYLHSY----SIVHRNLRSRNVLLTHDYTPVVSKLCFFSKSSLCHWV IRAKb_c-1_Smoe SRQNIALGAARGLRYLHEECRIGCIVHRDVRPNNILVTHDFTALVGDF------GLARWQ IRAKb_f_Smoe ARQKIALGAARALRYLHEECRVGCIVHRDMRPNNILLTHDFEPM---------------- IRAKb_g-2_Smoe SRHKIAVGAARGLRYLHEECRVGCIVHRDMRPNNILLTHDFEPMVGDF------GLARWQ *: :*:* *:.: *** ::**::*..*:*: **: . IRAKb_e_Smoe SNDDSAAQTRLVGTLGYLAPEYISSGEVTTKTDVYSFGVVLLELITGRRAINLSLPAGET IRAKb_b-2_Smoe TSSQPAVETKVVGTLGYLAPEYASSGQVTEKADVYSFGVILLEMVTGRRSLDISLPHAEQ IRAKb_c-2_Smoe ASGDTAEQTRVIGTIGYVAPEYAETGHITEKADVYSFGLVLLEIITGRPAFDSYQQPGQQ IRAKb_h_Smoe PDGELGVETRVIGTFGYLAPEYTQSGQITEKADVYSFGIVLLELVTGRKAIDISRPKGQQ IRAKb_b-1_Smoe TSSQPAVETKVIGTLGYLAPEYASSGQVTEKADVYSFGVILLEMVTGRRSLDISLPHAEQ IRAKb_d_Smoe NDS-AAPETTLVAATGYVAPEYGATGVATEKADVYSFGIVLLEIITGRRAIDLSC--EQT IRAKb_g-1_Smoe PDGDLGVETRVIGTFGYLAPEYAQTGHITEKADVFSFGVVLLELVTGRKAIDISRPRGQQ IRAKb_j_Smoe SFVFISDAIAHFHVDSYSAPEHFRGHAVDEKNDIFSYGVILLELITSRKAMEDS---SQR IRAKb_c-1_Smoe ARGDTAEQTRVIGTIGYVAPEYAETGQITEKADVYSFGLVLLEIITGRPAFDSYQQPGQQ IRAKb_f_Smoe ------------------------------------------------------------ IRAKb_g-2_Smoe PDGDLGVETRVIGTFGYLAPEYAQTGHITEKADVFSFGVVLLELVTGRKAIDISRPRGQQ IRAKb_e_Smoe SLIEWARPMIETREAESLIDKRLGDK----FNMYELHCMIHAASFCLRAAPSERATMSQV IRAKb_b-2_Smoe CLTEWARPKLDVRDADSLLDPRLVKDLLQESQLYEIQAMVHAAAFCLRREPSQRPRMSQV IRAKb_c-2_Smoe HLPDWATPFLAARAAHELLDERIDESS---IDEYELINMVTAASLCIQKDPSNRPKMSQV IRAKb_h_Smoe CLTEWARPLLRKRVYRELVDPKLCGE----FEKDEVTCMLHAAFLCISRDPNTRPRMSQV IRAKb_b-1_Smoe CLTEWARPKLDVRDADSLLDPRLVKDLLQESQLYEIQAMVHAAAFCLRREPSQRPRMSQV IRAKb_d_Smoe SLVEWARPKLEVRDAKSLLDPRLGTD----VDEYQIQCMIHAAAFCLQEDPSRRLRIKQV IRAKb_g-1_Smoe CLTEWARPLLEEQSHHELIDPALVNE----LNQYEAYCTLFAASLCIQRDAHLRPRMSQV IRAKb_j_Smoe LLTEWASPLLRDFDRQKLVDPELGCDD---NNTYELVTMMSIASLCLNEDPLERPSASKV IRAKb_c-1_Smoe HLPDWATPFLAARAAHELLDERIDESS---VDEYELINMVTAASLCIQKDPSKRPKMTQV IRAKb_f_Smoe -----ARPFLREQKYEKLIDQRLRGR----FCVNEVENMLLAATLCIDPDPLIRPRMSQV IRAKb_g-2_Smoe CLTEWARPLLEEQAHHELIDPALVNE----LNQYEAYCTLFAASLCIQRDAHLRPRMSQV * * : .*:* : : : * :*: . * .:* IRAKb_e_Smoe CVCLCLTKNSTR---------SLSCIPDFEDSRRRV------------------------ IRAKb_b-2_Smoe DT-YEE------------------------------------------------------ IRAKb_c-2_Smoe CSSLAV------------------------------------------------------ IRAKb_h_Smoe LRILEGEMIIDPAPASSLSDEDIPSRPVSEPTRRSTSAISSRKNRYIPSSVGHYSSGAAK IRAKb_b-1_Smoe DT-YEE------------------------------------------------------ IRAKb_d_Smoe SKNIK------------------------------------------------------- IRAKb_g-1_Smoe SQVFS------------------------------------------------------- IRAKb_j_Smoe NVRELECL-IA----------LLNIVPDF------------------------------- IRAKb_c-1_Smoe CSSLAV------------------------------------------------------ IRAKb_f_Smoe LRLLEGDSLSDTSLSSS-SSGLLNGSPVIAAV---------------------------- IRAKb_g-2_Smoe SKVFF------------------------------------------------------- IRAKb_e_Smoe -----------------------------IRSTCYCL IRAKb_b-2_Smoe -----------------------------------KS IRAKb_c-2_Smoe -----------------------------------TL IRAKb_h_Smoe EDGALARPNSGNLTLEELKAAYRHKLGHRRLSLGDAL IRAKb_b-1_Smoe -----------------------------------KS IRAKb_d_Smoe -----------------------------------TR IRAKb_g-1_Smoe ----------------------------------EEN IRAKb_j_Smoe ------------------------------EPARRGL IRAKb_c-1_Smoe -----------------------------------TL IRAKb_f_Smoe -----------------------------GAAVLQAY IRAKb_g-2_Smoe ----------------------------------EEN