CLUSTAL W (1.83) multiple sequence alignment IRAKj_c-2_Smoe MRGKNAGSSSCGSPALGILTAMSIGIGRWIVLGVV---VIAGAAAAVDPTERAVLDAMIQ IRAKj_a-2_Smoe MKLKKK-----------------HPAALLLLL---VASVLAMALAQTDSAELQVLQNFLK IRAKj_a-1_Smoe MKLKKK-----------------HPAALLLLL---VASILAMALAQTDSAELQVLQNFLK IRAKj_d-2_Smoe MERFRAGAMAAA----------RNPWKKLLLLVLLLVSLHWRCSATTNPGDLAVLQSFLQ IRAKj_b-1_Smoe MEQHS--------------------WKYFLLLGVL----LVSAAAETDPVDAEALQSFQK IRAKj_d-1_Smoe MERFRAGAMAGA----------RNLWKKLLLLALLLVSLHWRCTATTNPGDLAVLQSFLQ IRAKj_b-2_Smoe MEQHS--------------------WKYFLLLGVL----LVSAAAETDPVDAEALQSFQK IRAKj_c-1_Smoe MRGKNAGSSPRGSPALGILTAMSIGIGRWIVLGVV---IIAGAAAAVDPTERAVLDAMIQ *. ::* . * .:. : .*: : : IRAKj_c-2_Smoe GLTNGALL-GWGSGDPC--SWKHIQCRGQSIIGIAVESLGLVGTLPGNLNKLANLEYLGL IRAKj_a-2_Smoe GVKNPALLDSWTGSDPCGSNWKHIKCQGSSISALQVAGLALGGTVAPDLNKLKNLENLQL IRAKj_a-1_Smoe GVKNPALLDSWTGSDPCGSNWKHIKCQGSSISALQVAGLALGGTVAPDLNKLKNLENLQL IRAKj_d-2_Smoe GIDQKSVLTNWKNSDPCGDRWIHIKCTGAAVTALEMNNLQLGGTVTPDINKLSSLDSLQL IRAKj_b-1_Smoe GLSNGEIL-QWSGTDPCGAAWKHVQCRGKSVTGIDVAFLGLQGIVSPSLNRLSNLEYLGM IRAKj_d-1_Smoe GIDQKSVLTNWKNSDPCGDRWIHIKCTGAAVTALEMNNLQLGGTVTPDINKLSSLDSLQL IRAKj_b-2_Smoe GLSNGEIL-QWSGTDPCGAAWKHVQCRGKSVTGIDVAFLGLQGIVSPSLNRLSNLEYLGM IRAKj_c-1_Smoe GLTNGALL-GWGSGDPC--SWKHIQCRGQSIIGIAVESLGLVGTLPGNLNKLANLEYLGL *: : :* * . *** * *::* * :: .: : * * * :. .:*:* .*: * : IRAKj_c-2_Smoe QFNGFHGALPSLSGLKNLRTVYLNSNNFATIPGDFFRGLDSLMVIYLDHNNLNGT-AGWQ IRAKj_a-2_Smoe QGNGFTGSLPSLSGLSQLQTALLSGNSFDTIPGDFFTGLSALTEIYLDDNPLNKSSGGWM IRAKj_a-1_Smoe QGNGFTGSLPSLSGLSQLQTALLSGNSFDTIPGDFFTGLSALTEIYLDDNPLNKSSGGWM IRAKj_d-2_Smoe QQNGFTGSLPSLSGLTSLSRAYFGGNSFDTIPGDFFTGLTNVMEIFLEDNHVNST-QGWS IRAKj_b-1_Smoe QGNALSGSMPSLAGMANLKIAYFDNNDFSSIPGDFFAGLESLEAIYLDNNPLNGT-AGWE IRAKj_d-1_Smoe QQNGFTGSLPSLSGLTSLSRAYFGGNSFDTIPGDFFTGLTNVMEIFLEDNHVNST-PGWS IRAKj_b-2_Smoe QGNALSGSMPSLAGMANLKIAYFDNNDFSSIPGDFFAGLESLAAIYLDNNPLNGT-AGWE IRAKj_c-1_Smoe QFNGFHGALPSLSGLKNLRKVYLNSNNFATIPGDFFRGLDSLMVIYLDHNNLNGT-AGWQ * *.: *::***:*: .* . :..*.* :****** ** : *:*:.* :* : ** IRAKj_c-2_Smoe LPDDVQFSTKLVNLSLTNTSLGGPIPEFLGTMASLKVLNLAYNSLTGGLPASFKDSAMTQ IRAKj_a-2_Smoe LPAEIQNSSLLSTLSITNTSLGGSIPGFLGQMESLKVLNVAYNRISGGIPSSFGSSNLAE IRAKj_a-1_Smoe LPAEIQNSSLLSTLSITNTSLGGSIPDFLGQMESLKVLNVAYNRISGGIPSSFGSSNLAE IRAKj_d-2_Smoe LPADIQHCSNLQTLSITNTTLGGTIPGFLGTMSSLKNLYLAYNTLRGGIPATFAGSNLIK IRAKj_b-1_Smoe LPVDISHLGALANLSLTNSSVVGSIPAFLGAMPHLKVLNLAYNRLTGGIPPSFVSSNLVQ IRAKj_d-1_Smoe LPADIQHCSNLQTLSITNTTLGGTIPDFLGTMSSLKNLYLAYNTLRGGIPATFAGSNLIK IRAKj_b-2_Smoe LPVDISHLGALANLSLTNSSVVGSIPAFLGAMPQLKVLNLAYNRLTGGIPPSFVSSNLVQ IRAKj_c-1_Smoe LPDDVQFSTKLVNLSLTNTSLGGPIPEFLGTMASLKVLNLAYNSLTGGLPASFKDSAMTQ ** ::. * .**:**::: *.** *** * ** * :*** : **:*.:* .* : : IRAKj_c-2_Smoe LEVNNM----ALGGSIDVVGGMTSLAQLWLQGNQFTGTIPVGLSNAVAMADLRLNDNKLK IRAKj_a-2_Smoe FRANNQQN-PVLSGPITVVGTMQSLRVLWLHVNRFSGSIPDGLGEALSLQELKLNDNQLT IRAKj_a-1_Smoe FRANNQQN-PVLSGPITVVGTMQSLRVLWLHVNRFSGSIPEGLGEALSLQELKLNDNQLT IRAKj_d-2_Smoe FQANNQQGNEPLTGSIDPVASMQSLTTLWLHVNQFSGVIPPGLGNLSSLQDLKLNDNEFV IRAKj_b-1_Smoe LQANNMQG-PVLTGPIDAVGGMGSLVQLWLQVNEIAGTIPPGLGNALALQDLKLNDNRLT IRAKj_d-1_Smoe FQANNQQGNEPLTGSIDPVASMQSLTTLWLHVNQFSGVIPPGLGNLSSLQDLKLNDNEFV IRAKj_b-2_Smoe LQANNMQG-PVLTGPIDAVGGMGSLVQLWLQVNEIAGTIPRGLGNALALQDLKLNDNRLT IRAKj_c-1_Smoe LEVNNM----ALGGSIDVVGGMTSLAQLWLQGNQFTGTIPVGLSNAVAMADLRLNDNKLK :..** * *.* *. * ** ***: *.::* ** **.: :: :*:****.: IRAKj_c-2_Smoe GVVPN-FTALP-LSHFSVTNNNLMGPIPLLRATNTDGFGGNKFCQSEAGKACSAEVTALL IRAKj_a-2_Smoe GTIPPSLANLPALKNFTVKNNLLVGEIPVFKDTVGFEYARNNFCKSSPGEACARDVTALL IRAKj_a-1_Smoe GTIPPSLANLPALKNFTVKNNLLVGEIPVFKDTVGFEYARNNFCKSSPGEACARDVTALL IRAKj_d-2_Smoe GVVPQSLTQLPALKNFTIKGNMLVGPMPELGFS--YDGSTNGFCQATPGLPCDPRVTALL IRAKj_b-1_Smoe GPIPASLAELP-LAILSVDNNELIGVLPAFKPATKVLATGNNFCQAVPGLRCSHDVETLL IRAKj_d-1_Smoe GVVPQSLTQLPALKNFTIKGNMLVGPMPELGFS--YDGSTNGFCQATPGLPCDPRVTALL IRAKj_b-2_Smoe GPIPASLAELP-LAILSVDNNELIGVLPAFKPTTKVLATGNNFCQAVPGLRCSHDVETLL IRAKj_c-1_Smoe GVVPN-FTALA-LSHFSVTNNNLMGPIPLLRATNTDGFGGNKFCQSEAGKACSAEVTALL * :* :: *. * ::: .* *:* :* : : * **:: .* * * :** IRAKj_c-2_Smoe GFLGGI-GFPDSIIADWSGTDPCA-----------VTWVVCDRT-----AVIGLKLERNQ IRAKj_a-2_Smoe HFLAGV-GYPDSLTSSWIGNDPCGTSGSNGSSGSAWLGISCGSTPGTTSNVTVINLASSQ IRAKj_a-1_Smoe HFLAGV-GYPDSLTSSWIGNDPCGTSGSNGSSGSAWLGISCGSTPGTTSNVTVINLASSQ IRAKj_d-2_Smoe DFAGAADAFTSPCMTTWKGNDPCS-----------WTGINCVR-----GTVTTIQLPNCQ IRAKj_b-1_Smoe EFIGEF-GYPASIVSSWKGDDPCL-----------WTGIVCDSG----KRVSVIDLAGSQ IRAKj_d-1_Smoe DFAGAADAFTSPCMTTWKGNDPCS-----------WTGINCVR-----GTVTTIQLPNCQ IRAKj_b-2_Smoe EFIGEF-GYPASIVSSWKGDDPCL-----------WTGIVCDSG----KRVSVIDLAGSQ IRAKj_c-1_Smoe GFLGGI-GFPDSIIADWSGTDPCA-----------VTWVVCDGT-----AVIGLKLERNQ * . .:. . : * * *** : * * :.* * IRAKj_c-2_Smoe LAGTLSPAVAGLADLRFVMLSNNNLSGSIPPEFATMKSLKTLDLRNNSLSGPMVKF-SGV IRAKj_a-2_Smoe LNGTLSAALGNLTTLTTLRLSDNKLEGLIPESLAKLPSLQSVDLSNNLFSAPVPAFPSSV IRAKj_a-1_Smoe LNGTLSAALGNLTTLTTLRLSDNKLEGLIPESLAKLPSLQSVDLSNNLFSAPVPAFPSSV IRAKj_d-2_Smoe LNGSISTALANLTGLTALDLRNNHISGLLPAAIVQIPTLRNLNLFRNRLSGPLPPFPSGL IRAKj_b-1_Smoe LVGRLSPALVNLTALTVLRLNGNNISGGIPPVLTSMKSLQQVDLHNNNLSGDLPQFPESV IRAKj_d-1_Smoe LNGSISTALANLTGLTALDLRNNHISGLLPAAIVQIPTLRNLNLFRNRLSGPLPPFPSGL IRAKj_b-2_Smoe LVGRLSPALVNLTALTVLRLNGNNISGGIPPVLTSMKSLQQVDLHNNNLSGDLPQFPESV IRAKj_c-1_Smoe LAGTLSPAVAGLADLRFVMLSNNNLSGSIPPEFATMKSLKTLDLRNNSLSGPMVKF-SGV * * :*.*: .*: * : * .*::.* :* :. : :*: ::* .* :*. : * ..: IRAKj_c-2_Smoe TVLVDGNPLLN-TAPAGSAP--A----------------TTPSPPSPPGTPPPPGTQDDS IRAKj_a-2_Smoe KLNIAGNPLTP-AA----SP------GTSP--PGGTSGG-------PAATPDGQATATT- IRAKj_a-1_Smoe KLNIAGNPLTP-AA----SP------GTSP--PGGTSGG-------PAATPDGQATATT- IRAKj_d-2_Smoe QVNVDENPLTP-VSP-ASGS------GASP---SGSSGT------QAPGSPNAPSGAEQ- IRAKj_b-1_Smoe KTNFQGNPLLLQSLPPVTSP------PVAPAQPSGSSGGGGG-------AKNTNTTVANN IRAKj_d-1_Smoe QVNVDENPLTP-VSP-ASGS------GASP---SGSSGT------QAPGSPNAPSGAEQ- IRAKj_b-2_Smoe KTNFQGNPLLLQSLPPVTSP------PVTPAQPSGSSGGGGG-------AKNTNTTVANN IRAKj_c-1_Smoe TVLVDGNPLLN-SPP-GSAPVPPSSSPAAPAAPAGSAPATTPSPPSPPGTPPPPGTQDDS . *** .. : IRAKj_c-2_Smoe GNRTRPN-SPQASS-KFPIVGVAVPIAGVVSLALVAGVFIFFLCCRHKGKHQASRSSSSG IRAKj_a-2_Smoe ---R---------SKRVNAGPIVGVVVGLVALL-LVLFGICLLVYKKKGRKFLRLQGSNT IRAKj_a-1_Smoe ---R---------SKRVNAGPIVGVVVGLVALL-LVLFGICLLVYKKKGRKFLRLQGSNT IRAKj_d-2_Smoe --ST---------RRKVSPAAVAVPVVGAVAAV-AAAVSV-FVMCRRKRPRFMRVQSSSA IRAKj_b-1_Smoe --ATAAEVLPRSHHNSVKAGLIAGPVVGAVSLL-AIGLALSFLFYKRSEKRFVRVQG-PT IRAKj_d-1_Smoe --ST---------RRKVSPAAIAVPVVGAVAAV-AAAVSV-FVMCRRKRPRFMRVQSSSA IRAKj_b-2_Smoe --ATAAEVLPRSQHNSVKAGLIAGPVVGAVSLL-AIGLALSFLFYKRSEKRFVRVQG-PT IRAKj_c-1_Smoe GNR--TN-SPQASS-KFPIVAVAVPIAGAVSLALVAGVFIFFLCCRHKGKHQASRSSSSG . :. :.* *: . : :: ::. : .. IRAKj_c-2_Smoe MLVHPRN--SNSDPDMVKVSVTRTA---------EPNGGGNHSGPSGDVHVVEAGNLVIS IRAKj_a-2_Smoe VVVHPRTDNSSDDPEVVKIVVNNNMITS----DNSDTQSRANSGPSDHVQVVEAGNLVIS IRAKj_a-1_Smoe VVVHPRTDNSSDDPEVVKIVVNNNMITS----DNSDTQSRANSGPSDHVQVVEAGNLVIS IRAKj_d-2_Smoe IVVHPRD--SSFERETVKLPTS--------------VAKEGHSGPSE-V-RVETGNLVIS IRAKj_b-1_Smoe MVVHPRD--SSSE-DIVKIIVPGGAGNNVNSRSLVETAS-VNSNGT-DVQVVEAGNLVIS IRAKj_d-1_Smoe IVVHPRD--SSFERETVKLPTS--------------VAKEGHSGPSE-V-RVETGNLVIS IRAKj_b-2_Smoe MVVHPRD--SSSE-DIVKIIVPGGAGNNVNSRSLVETAS-VNSNGT-DVQVVEAGNLVIS IRAKj_c-1_Smoe MLVHPRN--SNSDPDMVKVSVTRTA---------EPNGGGNHSGPSGDVHVVEAGNLVIS ::**** *. : : **: . :*. : * **:****** IRAKj_c-2_Smoe IQVLRDATKNFSRDTILGRGGFGVVYKGVLDDGTSIAVKRMEASTVVSSKGLSEFHAEIA IRAKj_a-2_Smoe IHVLREATKNFSEATILGRGGFGVVYKGVLDDGTAIAVKRMESNCVVSNKGLGEFQAEIA IRAKj_a-1_Smoe IHVLREATKNFSEATILGRGGFGVVYKGVLDDGTAIAVKRMESNCVVSNKGLGEFQAEIA IRAKj_d-2_Smoe IHVLRKATNGFSENSILGRGGFGVVYKGELDDGTKIAVKRMES-AVVNNKGLSEFQAEIQ IRAKj_b-1_Smoe IHVLRNATRNFSEETVLGRGGFGAVYRGQLDDGTNIAVKRMEASSVVSSKGVSEFHAEIA IRAKj_d-1_Smoe IHVLRKATNGFSENSILGRGGFGVVYKGELDDGTKIAVKRMES-AVVNNKGLSEFQAEIQ IRAKj_b-2_Smoe IHVLRNATRNFSEETVLGRGGFGAVYRGQLDDGTNIAVKRMEASSVVSSKGVSEFHAEIA IRAKj_c-1_Smoe IQVLRDATKNFSRDTILGRGGFGVVYKGVLDDGTSIAVKRMEASTVVSSKGLSEFHAEIA *:***.**..**. ::*******.**:* ***** *******: **..**:.**:*** IRAKj_c-2_Smoe VLTKVRHRHLVALLGYCIEGNEKLLVYEYLPNGTLAQHLFER---GAKPLDWKRRLVIAL IRAKj_a-2_Smoe VLTKVRHRHLVALLGYCIEGNEKMLVYEFMPQGTLSQHLFEAAKCGYPPLDWKQRLSVAL IRAKj_a-1_Smoe VLTKVRHRHLVALLGYCIEGNEKMLVYEFMPQGTLSQHLFEAAKCGYPPLDWKQRLSVAL IRAKj_d-2_Smoe VLTKVRHRHLVALLGYCIDGNEKLLVYEYMPQGTLSQHLFEFAKHGYHHLTWKHRLSIAL IRAKj_b-1_Smoe VLSKVRHRHLVALLGYCIDGNEKLLVYEYLPQGALSHHLFEYRRMRLKPLEWKRRLAIAL IRAKj_d-1_Smoe VLTKVRHRHLVALLGYCIHGNEKLLVYEYMPQGTLSQHLFEFAKHGYHHLTWKHRLSIAL IRAKj_b-2_Smoe VLSKVRHRHLVALLGYCIDGNEKLLVYEYLPQGALSHHLFEYRRMRLKPLEWKRRLAIAL IRAKj_c-1_Smoe VLTKVRHRHLVALLGYCIEGNEKLLVYEYLPNGTLAQHLFER---GAKPLDWKRRLVIAL **:***************.****:****::*:*:*::**** * **:** :** IRAKj_c-2_Smoe DVARGMEYLHELAHRSFIHRDLKPSNILLDDDYRAKVSDFGLVKLAPEGKYSIETRLAGT IRAKj_a-2_Smoe DVARGMEYLHGLAHRSFIHRDLKPSNILLGDDLRAKVSDFGLVKLAPEGKYSVETRLAGT IRAKj_a-1_Smoe DVARGMEYLHGLAHRSFIHRDLKPSNILLGDDLRAKVSDFGLVKLAPEGKYSVETRLAGT IRAKj_d-2_Smoe DVARGIEYLHGLAHKSFIHRDLKPSNILLDDTLHAKVADFGLVKLAPEGKVSVETRLAGT IRAKj_b-1_Smoe DVARGMEYLHGLAYKSFIHRDLKPSNILLDDDLRAKVADFGLVKLAPEGKYSVETRLAGT IRAKj_d-1_Smoe DVARGIEYLHGLAHKSFIHRDLKPSNILLDDTLHAKVADFGLVKLAPEGKVSVETRLAGT IRAKj_b-2_Smoe DVARGMEYLHGLAYKSFIHRDLKPSNILLDDDLRAKVADFGLVKLAPEGKYSVETRLAGT IRAKj_c-1_Smoe DVARGMEYLHELAHMSFIHRDLKPSNILLDDDYRAKVSDFGLVKLAPEGKYSIETRLAGT *****:**** **: **************.* :***:************ *:******* IRAKj_c-2_Smoe FGYLAPEYAVTGRVTTKADVFSFGVVLMELITGRRALDESQSEENMHLVTWFRRTH--QG IRAKj_a-2_Smoe FGYLAPEYAVTGRVTTKADVFSFGVVLMELITGRRALDETQAEENMHLVTWFRRST--AN IRAKj_a-1_Smoe FGYLAPEYAVTGRVTTKADVFSFGVVLMELITGRRALDETQAEENMHLVTWFRRST--AN IRAKj_d-2_Smoe FGYLAPEYAVTGRVTTKVDVYSFGVILMELITGRQALDTSRSEETMHLPTWFKRMR--VN IRAKj_b-1_Smoe FGYLAPEYAVTGRVTTKADVFSFGVVLLELISGRRALDESQPEENMHLVTWYRRITSSSS IRAKj_d-1_Smoe FGYLAPEYAVTGRVTTKVDVYSFGVILMELITGRQALDTSRSEETMHLPTWFKRMR--VN IRAKj_b-2_Smoe FGYLAPEYAVTGRVTTKADVFSFGVVLLELISGRRALDESQPEENMHLVTWYRRITSSSS IRAKj_c-1_Smoe FGYLAPEYAVTGRVTTKADVFSFGVVLMELITGRRALDESQSEENMHLVTWFRRTH--QG *****************.**:****:*:***:**:*** ::.**.*** **::* . IRAKj_c-2_Smoe RESFARMIDPALLE--GTEDKVEGIYTVAELAKHCTAREPYNRPDMGHAVSVLAPLVEQW IRAKj_a-2_Smoe KEGVRKLIDPAIE----SDDNFASISVVAELAGHCTAREPYQRPDMGHAVNVLSPLVEHW IRAKj_a-1_Smoe KEGVRKLIDPAIE----SDDNFASISVVAELAGHCTAREPYQRPDMGHAVNVLSPLVEHW IRAKj_d-2_Smoe RETFRSSLDPVLE---VTDEEFESICSVAELAGYCTMREPYQRPDMSHAVNVLAPMVERW IRAKj_b-1_Smoe KESLLRIIDPVLGVGDVTGDVFHSVYTVSELARHCTAREPYQRPDMGHAVSVLSPLVDQW IRAKj_d-1_Smoe RETFRSSLDPVLE---VTDEEFESICSVAELAGYCTMREPYQRPDMSHAVNVLAPMVERW IRAKj_b-2_Smoe KESLLRIIDPVLG----VGDVFHSVYTVSELARHCTAREPYQRPDMGHAVSVLSPLVDQW IRAKj_c-1_Smoe RESFARMIDTALLE--GTEDKVEGIYTVAELAKHCTAREPYNRPDMGHAVSVLAPLVEQW :* . :*..: : . .: *:*** :** ****:****.***.**:*:*::* IRAKj_c-2_Smoe KPTASDGEETKGIDLNVSLPQALKQWQASDDSN---------L--DDSQASIPTRPVGFA IRAKj_a-2_Smoe KPV-DYEDESGGIDLDVPLPQAVKRWQELDSGGGGGGAA-AVW--SDTQSSLPPRPSGFA IRAKj_a-1_Smoe KPV-DYEDESGGIDLDVPLPQAVKRWQELDSGGGGGGAA-AVW--SDTQSSLPPRPSGFA IRAKj_d-2_Smoe KPSMDFDAEEGGIDLGLSLSEALRRWQESETG----------M--DETRTSLPTRPPGFA IRAKj_b-1_Smoe KPADQDGEESAGIDLSLTLPQALKKWQASEEDSSSGAASRRMLDDYDSHDSLPTRPAGFA IRAKj_d-1_Smoe KPSMDFDAEEGGIDLGLSLSEALRRWQESETG----------M--DETRTSLPTRPPGFA IRAKj_b-2_Smoe KPADQDGEESAGIDLSLTLPQALKKWQAYEEDSSSGAASRRMLDDYDSHDSLPTRPAGFA IRAKj_c-1_Smoe KPTASDGEETKGIDLNVTLPQALKQWQASDDSN---------L--DDSQASLPTRPVGFA ** . * ****.:.*.:*:::** : . ::: *:*.** *** IRAKj_c-2_Smoe DSFTSSDAR IRAKj_a-2_Smoe ETFTSEDAR IRAKj_a-1_Smoe ETFTSEDAR IRAKj_d-2_Smoe DSFSSTDVR IRAKj_b-1_Smoe EAFTAADGR IRAKj_d-1_Smoe DSFSSTDVR IRAKj_b-2_Smoe EAFTAADGR IRAKj_c-1_Smoe DSFTSSDAR ::*:: * *