CLUSTAL W (1.83) multiple sequence alignment IRAKk_c-1_Smoe MRRIL---------------------------------------------------VELA IRAKk_g_Smoe ------------------------------------------------------------ IRAKk_e-2_Smoe C------------------------------CMDNMMNRPGGETCSCVYPIEIGLLLDNV IRAKk_b-2_Smoe MDTYI------------------------------------------------------- IRAKk_c-2_Smoe MRRVL---------------------------------------------------VELA IRAKk_b-1_Smoe MDTYI------------------------------------------------------- IRAKk_a-1_Smoe MLMN------------------------------------------------------HS IRAKk_a-2_Smoe MLMN------------------------------------------------------HS IRAKk_e-1_Smoe HPG---------------------------CCVDNMMNRPGGETCSCVYPIEIGLLLDNV IRAKk_f_Smoe ------------------------------------------------------------ IRAKk_d_Smoe MVFPSPPNAGIFFFLLRVCVSRSFYAGCDKVCSDPSVTTLPGTKCGCVIPMRVGLALEIP IRAKk_c-1_Smoe GDNTS-----------------------------EDN----------------------- IRAKk_g_Smoe ------------------------------------------------------------ IRAKk_e-2_Smoe SSNFINSTVAFQHQLASQLKLQDPQVVITAFYYIS--TSELNMSIYLGPLVGVSFSSEEA IRAKk_b-2_Smoe ------------------------------------------------------------ IRAKk_c-2_Smoe GDNTS-----------------------------EDN----------------------- IRAKk_b-1_Smoe ------------------------------------------------------------ IRAKk_a-1_Smoe SNNSY-----------------------------SSP----------------------- IRAKk_a-2_Smoe SNNSY-----------------------------SSP----------------------- IRAKk_e-1_Smoe SSNFINSTVAFQHQLASQLKLQDPQVVITAFYYIT--TSELNMSIYLGPLVGVSFSSQEA IRAKk_f_Smoe ------------------------------------------------------------ IRAKk_d_Smoe ISSFLSLVSELAMEIAFGISMQQMQVQIAAANSFGEDFSLTETKVNLVPL-GNAFRNQTA IRAKk_c-1_Smoe -----------------------------------LVLIIAIIIASAALV--LVAIAF-A IRAKk_g_Smoe ------------------------------------------------------------ IRAKk_e-2_Smoe TSVKASLDAHKVRFNSSLVGNYTLLRFNLFGPEPVSP-SPSPVFAPSPSR--NQPLSTPT IRAKk_b-2_Smoe ------------------------------------------------------------ IRAKk_c-2_Smoe -----------------------------------LVLIIAIIIASAALV--LVAIAF-A IRAKk_b-1_Smoe ------------------------------------------------------------ IRAKk_a-1_Smoe -----------------------------------SP-TPRPVLPPPSLL--TLQISPPP IRAKk_a-2_Smoe -----------------------------------SP-TPRPVLPPPSLL--TLQISPPP IRAKk_e-1_Smoe TSVKASLDAHKVRFNSSLVGNYTLLRFNLFGPEPVSP-SPSPVFAPSPSR--NQPLSTPT IRAKk_f_Smoe ------------------------------------------------------------ IRAKk_d_Smoe YHISQMFWGHRVPINEAYFVNYTVLYV-IYPGLPLAS-QNVNRIPPSDGKFPDQPLGVDI IRAKk_c-1_Smoe YYC--------------------------------------YLRHKARAPRQEVAEQAK- IRAKk_g_Smoe ------------------------------------------------------------ IRAKk_e-2_Smoe NNQSSASERPKGKVRLGIILGVGIAI-VALLCLSILF-----IR--KLAPGNKESEEKA- IRAKk_b-2_Smoe -----------------------------------------------RSERDE------- IRAKk_c-2_Smoe YYC--------------------------------------YLRHKARAPRQE------- IRAKk_b-1_Smoe -----------------------------------------------RSEREE------- IRAKk_a-1_Smoe NNC----------------------------------------SGAGGEERDHI------ IRAKk_a-2_Smoe NNC----------------------------------------SGAGGEERDHI------ IRAKk_e-1_Smoe NNQSSASERPKGKVRLGIILGVGIAI-VALLCLSILF-----IR--KLAPGNKESEEKA- IRAKk_f_Smoe ------------------------------------------------------------ IRAKk_d_Smoe FARRNRNLHPA-------FIAIITLSCVFLLILCLGVGWLITVRHRGRYKGHSELTEAAL IRAKk_c-1_Smoe -SVTSQ------SISLS-----RRS-SYN-GSTSEAQVFTYKQMQAATNNFTTSNEVGQG IRAKk_g_Smoe -------------------------------------VMDYKMLESATDRFSEENLIGEG IRAKk_e-2_Smoe -SLTKS-----------ASDPPQML-SLL-TRPTSTRIFSYEDLKEATNGFDPANLLGEG IRAKk_b-2_Smoe --------------------------------VSKAQVFTYKQLQSATNNFSPLNKIGHG IRAKk_c-2_Smoe ------------------------G-TYN-GSTSEAQVFTYKQMQAATNNFTTSNEVGQG IRAKk_b-1_Smoe --------------------------------VSKAQVFTYKQLQSATNNFSPLNKIGHG IRAKk_a-1_Smoe ----------------------------A-IKRPGPQPFSFHQLQIATNSFSERNIIGRG IRAKk_a-2_Smoe ----------------------------A-IKRPGPQPFSLHQLQIATNSFSERNIIGRG IRAKk_e-1_Smoe -SLTKS-----------ASDPPQML-SLL-TRPTSTRIFSYEDLKEATNGFDPANLLGEG IRAKk_f_Smoe -------------------------------------M---------------------- IRAKk_d_Smoe ESCATKRSTTATLLSNSSRDSTSVSSSIVPYVSGSVRTFTLAEMTAATNNFNPSNVIGQG IRAKk_c-1_Smoe GFGSVFRGVLPDGRTAAIKQLDRGGKQGDREFRVEVDMLSRLHSPHLLELIGYCAD--QE IRAKk_g_Smoe GFARVYKAQLDDDHAIAVKKLSTENDQADEEFRAEINLMGRIHHPNLIALLGFSSQ--GE IRAKk_e-2_Smoe GFGRVYRGNLKDGMAVAIKRLSSGGHQGDKEFLVEVEMLSRLHHRHLVKLVGFFSSRDSS IRAKk_b-2_Smoe GFGLVYRGVLPDGRLAAVKLMDRQGKQGEREFRVEVDMLTRLHSPYLLDLIGYCAD--KD IRAKk_c-2_Smoe GFGSVFRGVLPDGRTAAIKQLDRGGKQGDREFRVEVDMLSRLHSPHLLELIGYCAD--QE IRAKk_b-1_Smoe GFGLVYRGVLPDGRLAAVKLMDRQGKQGEREFRVEVDMLTRLHSPYLLDLIGYCAD--KD IRAKk_a-1_Smoe GFGCVYRGILADGRVAAIKKLDLEGKQGEEEFRVEIEMLSRVQAPKLLELLGYCTE--DE IRAKk_a-2_Smoe GFGCVYRGILADGRVAAVKKLDLEGKQGEEEFCVEIEMLSRVQAPKLLELLGYCTE--NE IRAKk_e-1_Smoe GFGRVYRGNLKDGMAVAIKRLSSGGHQGDKEFLVEVEMLSRLHHRHLVKLVGFFSSRDSS IRAKk_f_Smoe ---------------VAVTLF--------AFFQAEINLMGRIHHPNLIALLGFSSQ--GE IRAKk_d_Smoe GFGRVYSGVLTDGTKIAVKVLIREDKQGDREFSAEVEMLSRLHHRNLVKLVGICTD--DD *:. : * .*:::: *:: *: *:* :. . IRAKk_c-1_Smoe HRLLVYEFMPNGSVQEHLHSDGTSGRPPMLDWDTRMRVALDAARGLEYLHEMVSPPIIHR IRAKk_g_Smoe DRLLIYELMTNGSLQDQLQGPAQ---GAALTWHLRLKIALDAARGLEYLHDHCDPPVIHR IRAKk_e-2_Smoe QHLLCYELVPNGSLESWLHGRLG--ANNPLDWDTRMKIAIGAARGLAYLHEDCQPCVIHR IRAKk_b-2_Smoe YRLLVYSYMANGSLQEHLHSKGK----STLDWGTRILVAFDAAKGLEYLHEYVIPPIIHR IRAKk_c-2_Smoe HRLLVYEFMPNGSVQEHLHSDGTSGRPPMLDWDTRMRVALDAARGLEYLHEMVSPPIIHR IRAKk_b-1_Smoe YRLLVYSYMANGSLQEHLHSKGK----STLDWGTRILVAFDAAKGLEYLHEYVIPPIIHR IRAKk_a-1_Smoe HRLLVYEYMAKGNLQQHLYPDDDDHGFVPLDWTTRLKIALDAAKGLEFLHEFVTPPIIHR IRAKk_a-2_Smoe HRLLVYEYMAKGNLQQHLYPDEDDHGFVPLDWTTRLKIALDAAKGLEFLHEFVTPPIIHR IRAKk_e-1_Smoe QHLLCYELVPNGSLESWLHGRLG--ANNPLDWDTRMKIAIGAARGLAYLHEDCQPCVIHR IRAKk_f_Smoe DRLLIYELMTNGSLQDQLQGPAQ---GAALTWHLRLKIALDAARGLEYLHDHCDPPVIHR IRAKk_d_Smoe MRSLVYELIPNGSVDSHLHGDDK--KIAPLSWEARLKIALGAARGLAYLHEDSYPRVIHR : * *. :.:*.::. * * * *: :*:.**:** :**: * :*** IRAKk_c-1_Smoe DFKSSNILLDDKFNAKVSDFGLAKLGSDKAGGHVSTRVLGTQGYVAPEYALTGHLTTKSD IRAKk_g_Smoe DFKSSNILLDEDFNAKLSDFGLALMVQEGA---GSLQLQGTFGYVAPEYILTGILTEKSD IRAKk_e-2_Smoe DFKASNILLEDNFQAKVADFGLAKQAPEGQTSYVSTRVMGTFGYVAPEYAMTGHLLVKSD IRAKk_b-2_Smoe DFKSSNILLDEHNDVVLADFGLAKTGADKIAGQPSTRVLGTQGYLAPEYAMTGHLTTKSD IRAKk_c-2_Smoe DFKSSNILLNDKYNAKVSDFGLAKLGSDKAGGHVSTRVLGTQGYVAPEYALTGHLTTKSD IRAKk_b-1_Smoe DFKSSNILLDEHNDVVLADFGLAKTGADKIAGQPSTRVLGTQGYLAPEYAMTGHLTTKSD IRAKk_a-1_Smoe DFKCSNILLDDKLNAKLSDFGLAKVGSNKVNGDVSTRVLGTHGYVAPEYVLTGHLTTKSD IRAKk_a-2_Smoe DFKCSNILLDDKLNAKLSDFGLAKVGSNKVNGDVSTRVLGTHGYVAPEYVLTGHLTTKSD IRAKk_e-1_Smoe DFKASNILLEDNFQAKVADFGLAKQAPEGQTSYVSTRVMGTFGYVAPEYAMTGHLLVKSD IRAKk_f_Smoe DFKSSNILLDEDFNAKLSDFGLALMVQEGA---GSLQLQGTFGYVAPEYILTGILTEKSD IRAKk_d_Smoe DFKSSNILLEDDFTPKVSDFGLAKAASEELTGHISTRVMGTFGYVAPEYAMTGHLLVKSD ***.*****::. ::***** : * :: ** **:**** :** * *** IRAKk_c-1_Smoe VYSFGVVLLELLTGRVPVDMKRPPGEGVLVSWALPRLTDRNKMVEIIDPRLNGQFAMKDL IRAKk_g_Smoe VYAFGVVLLELITGRKPIDVSMPTGCQSLVTWATPQLTDRTRLPLIVDAAIKDTVNLKQL IRAKk_e-2_Smoe VYSYGVVLLELLSGRKPVDMAQPTGQENLVTWARPVLKDVDRIYELADPRLNGQYPREDF IRAKk_b-2_Smoe VYSYGVVLLELITGRLPVDAKRPPGQNVLVNWALPRLTDREKLAQMVDPYLRSQYNMKEL IRAKk_c-2_Smoe VYSFGVVLLELLTGRVPVDMKRPPGEGVLVSWALPRLTDRNKMVEIIDPRLNGQFAMKDL IRAKk_b-1_Smoe VYSYGIVLLELITGRLPVDAKRPPGQNVLVNWALPRLTDREKLAQMVDPYLRSQYNMKEL IRAKk_a-1_Smoe VYSFGVVLLEILTGRVPVDMKRPAGEGVLVSWALPRLTDRDKLVGMVDQALAGQYSMKEL IRAKk_a-2_Smoe VYSFGVVLLEILTGRVPVDMKRPAGEGVLVSWALPRLTDRDKLVGMVDQALAGQYSMKEL IRAKk_e-1_Smoe VYSYGVVLLELLSGRKPVDMAQPTGQENLVTWARPVLKDVDHIYDLADPRLNGQYPREDF IRAKk_f_Smoe VYAFGVVLLELITGRKPIDVSMPTGCQSLVTWATPQLTDRTRLPLIVDAAIKDTVNLKQL IRAKk_d_Smoe VYSYGVVLLELLSGRKPVDMSRAQGQENLVTWARPLLTSLEGLDFLADPDLRSSVAPENL **::*:****:::** *:* . * **.** * *.. : : * : . ::: IRAKk_c-1_Smoe IQIAAIAAMCVQPEADYRPFITDVVQSLVPLVKHNRP----------MR-VSSSPSFLHA IRAKk_g_Smoe FQVAAVAVLCVQSEPSYRPLIGDVVNSLIPLVPCELGGA--------LR-AID-PA---- IRAKk_e-2_Smoe AQVAAVAAACVAPEANQRPTMGEVVQSLKMVQHSNEYTHSGERENMTVETPVS-PSMSDG IRAKk_b-2_Smoe VQVAAIAAMCVQPEPDYRPLITDVVQSLIPLVRQRRMGT-------PKR-SVSSPRCVSS IRAKk_c-2_Smoe IQIAAIAAMCVQPEADYRPFITDVVQSLVPLIKHNRP----------MR-VLSSPSFLHA IRAKk_b-1_Smoe VQVAAIAAMCVQPEPDYRPLITDVVQSLIPLVRQRRMGT-------PKR-SVSSPRCVSS IRAKk_a-1_Smoe IQVAAIAAMCIQPEADYRPLMIDVVQSLAPLVKQRLQ----------------------- IRAKk_a-2_Smoe IQVAAIAAMCIQPEADYRPLMIDVVQSLAPLVKQRLQ----------------------- IRAKk_e-1_Smoe AQVAAVAAACVAPETNQRPTMGEVVQSLKMVQHSNEYTHSGERENMTVETPVS-PSMSDG IRAKk_f_Smoe FQVAAVAVLCVQSEPSYRPLIGDVVNSLIPLVPCELGGA--------LR-AID-PS---- IRAKk_d_Smoe ARVAAIASMCVRPEVSQRPFMGEVVQALKLVCSDMDV-EEGET-SGASN-SVSSPEAKAK ::**:* *: .* . ** : :**::* : IRAKk_c-1_Smoe -TVT-------------------------------------------------------- IRAKk_g_Smoe --GAT------------------------------------------------------- IRAKk_e-2_Smoe -TFATSW--------------------------------------NNHNTRQTSATFESD IRAKk_b-2_Smoe -LL--------------------------------------------------------- IRAKk_c-2_Smoe -IVT-------------------------------------------------------- IRAKk_b-1_Smoe -LL--------------------------------------------------------- IRAKk_a-1_Smoe ------------------------------------------------------------ IRAKk_a-2_Smoe ------------------------------------------------------------ IRAKk_e-1_Smoe -TFATSW--------------------------------------HNHNTRQTSATFESD IRAKk_f_Smoe --GAT------------------------------------------------------- IRAKk_d_Smoe VTAASTSRQREWDFLSYRSSSDFDDQQKSLRNHQRQQGQGGNFSASSALLRQVSASFGRH IRAKk_c-1_Smoe --------------------VKSSSAESGSSDCRSSHVSF IRAKk_g_Smoe ------------------------------AANSHSQHGV IRAKk_e-2_Smoe GTS---SFFSSGPFSGLAALDEGEDAQRGPTMSEDLLEGR IRAKk_b-2_Smoe ---------------------KSPTTQSPAL-KANIKTLQ IRAKk_c-2_Smoe --------------------VKSSSAESGSSDCRSSHVSF IRAKk_b-1_Smoe ---------------------KSPTTQSPAL-KANIKTLQ IRAKk_a-1_Smoe ------------------------------------NRTG IRAKk_a-2_Smoe ------------------------------------NRTG IRAKk_e-1_Smoe GTS---SFFSSGPFSGLAALDEGEDAQRGPTMSEDLLEGR IRAKk_f_Smoe ------------------------------AANSHSQHGV IRAKk_d_Smoe SAPEPLKFFNKS--ERFLTLPPGSASEHGVHHYRESTVWP