CLUSTAL W (1.83) multiple sequence alignment KHS2_Hsap MN----------PGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLE KHS1_Hsap MEAPL------RPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE HPK1_Hsap MDV---------VDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKME GCK_Hsap MA----------LLRDVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLD KHS2_Mmus MN----------PGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLE KHS1_Mmus MEAPL------RPAADILRRNPQHDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE HPK1_Mmus MAL---------VDPDIFNKDPREHYDLLQRLGGGTYGEVFKARDKVSKDLVALKMVKME GCK_Mmus MA----------LLRDVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLD CG7097_Dmel MAAAHSHHNANMLSSDISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLE ZC404.9_Cele MSA-----------DVIKRSNPADDYELLQRVGSGTYGEVYKARDIRSDSLAAVKVVKLE KHS_Spur MSQT--------PSAEISRKNPLEDFELLQRIGSGTYGDVYKARMTAAGTLSAIKVIKIE AqueK230_Aque MAISP-----DGILPNISRKNPERDFELVKQIGSGTYGEVYKAKLVKTGQLCALKIIKIE AqueK231_Aque MAST--------LLPEIQLKDPVQDFELLSQIGSGGYGVVYKAKTVSDGQLCALKIIKIK * : :* ::*:.::*.* ** *:**: * *:*::*:. KHS2_Hsap PGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTG-PLS KHS1_Hsap PGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTG-PLS HPK1_Hsap PDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTG-SLS GCK_Hsap PGDDISSLQQEITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATG-PLE KHS2_Mmus PGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTG-PLS KHS1_Mmus PGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTG-PLS HPK1_Mmus PDDDVATLQKEILMLKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTG-SLS GCK_Mmus PGDDISSLQQEITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATG-PLE CG7097_Dmel PSDDIQIIQQEIIMMRDCRHPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTG-PLT ZC404.9_Cele AGDNFAVIQQEIMVIRECSHPNIIAYFGSYIRRDRLWIVMEYCGGGSLQDIYHLTG-PLS KHS_Spur PGDDFTIIQQEILMMKDCRHANIVGYFGSYLRREKLWIAMEYCGGGSLQDIYHMTG-HLA AqueK230_Aque PGEDFNIIQQEILILSECKHANIVGYLGSYLRxxxxxxxxxxxxxxxxxxxxxxxx-xxx AqueK231_Aque AGEDFNLIQKEISILSHCKHPNIVGYYSSYLRKDKLWISMEFCEAGSLYNMMHVQHSGLN ..::. :*:** :: * * *::.* .**: KHS2_Hsap ELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRK KHS1_Hsap ELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRK HPK1_Hsap ELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRL GCK_Hsap ERQIAYVCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRR KHS2_Mmus ELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRK KHS1_Mmus EMQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRK HPK1_Mmus ELQISYVCREVLQGLAYLHSEKKIHRDIKGANILINDCGEVKLADFGISAQIGATLARRL GCK_Mmus ERQIAYVCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRR CG7097_Dmel EVQIAYMCRETLKGLEYLHSMGKMHRDIKGANILLTEYGDVKLADFGVSAQITATINKRK ZC404.9_Cele ELQIAFVCRETLRGLNYLHNMGKIHRDIKGANILLSSSGDVKLADFGVAAQITATIGKRK KHS_Spur ELQIAYVCQQTLTGLAYMHTLGKMHRDIKGANILLTDDGDVKLADFGVSAQITQTIAKRK AqueK230_Aque xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx AqueK231_Aque ELQIAFVCKETLQGLTYLHERNILHRDIKSANILLTHDTVVKLADFGIATQLTQTMGKRK KHS2_Hsap SFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKS KHS1_Hsap SFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKS HPK1_Hsap SFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKS GCK_Hsap SFIGTPYWMAPEVAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKS KHS2_Mmus SFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKS KHS1_Mmus SFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKS HPK1_Mmus SFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKS GCK_Mmus SFIGTPYWMAPEVAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKS CG7097_Dmel SFIGTPYWMAPEVAAVERKGGYNQLCDIWACGITAIELAELQPPMFDLHPMRALFLMSKS ZC404.9_Cele SFIGTPYWMAPEVACVEKRGGYGMQCDVWATGITAIELGECQPPLFDLHPMQVLYLMTKS KHS_Spur SFIGTPYWMAPEVAAVERKGGYDFQCDIWAVGITAIELAELQPPMFDLHPMRALFLMSKS AqueK230_Aque xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxALYLMTKR AqueK231_Aque TFIGTPYWMAPEVAAVDKKGGYNQKCDIWSLGITAIELAEMQPPMNDLHPFRSVTIN--- : : KHS2_Hsap NFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQ-HPFVTQ---HLTRSLAIEL KHS1_Hsap NFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLT-HTFVAQP--GLSRALAVEL HPK1_Hsap GYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLS-HQLVSQP--GLNRGLILDL GCK_Hsap SFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQ-HPFTTQ---QLPRALLTQL KHS2_Mmus NFQPPKLKDKLKWSNSFHHFVKMALTKNPKKRPNAEKLLQ-HPFVTQ---PLTRSLAIEL KHS1_Mmus NFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLT-HTFVGQP--GLSRALAVEL HPK1_Mmus GYQPPRLKEKSRWSSSFHNFVKVTLTKNSKKRPSATKMLS-HQLVSQP--GLNRGLILDL GCK_Mmus SFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAERLLQ-HPFTTQ---HLPPALLTQL CG7097_Dmel GFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRPTAERLLQ-HPFVQC---EMSLRVAKEL ZC404.9_Cele GYKPPHLKDKHRWTPLFHDFVRQCLTKNPKKRPSPEKLLTSHPFVLG---SLSARMTRDL KHS_Spur NFVPPKLKDKNKWSPIFHAFIKTALIKNPKKRPTASKLLQ-HPYFQDNIDRLTEQTMRQL AqueK230_Aque NFRPPTLQHKNKWSNNFHDFLSQALKKDPKIRPNADDLLK-HEFVHR---DLSGLLMVPL AqueK231_Aque -------------------------------------IL-WDDFVKR---DLSGLLMGPL :* . : * KHS2_Hsap LDKVNNPDHS--T-Y-----HDFDDDDP----EPL----VAVPHRIHSTSRNVREEKT-- KHS1_Hsap LDKVNNPDNHA-H-Y-----TEADDDDF----EPH----AIIRHTIRSTNRNARAERT-- HPK1_Hsap LDKLKNPGKGPS--I-----GDIEDEEP----ELP----PAIPRRIRSTHRSSSLGIP-- GCK_Hsap LDKASDPHLG--T-P------SPEDCEL----ETY----DMFPDTIHSRGQHGPAERT-- KHS2_Mmus LDKVNNPDHS--T-Y-----HDFDDDDP----EPL----VAVPHRIPSTSRNVREEKT-- KHS1_Mmus LDKVSNPDNHA-P-Y-----SEGDEDDL----EPH----AIIRHTIRSTNRNSRAERT-- HPK1_Mmus LDKMKNPGKGLP--------VDIEDEEP----EPP----PAIPRRIRSTYRASSLGIP-- GCK_Mmus LDKASDPHLG--T-L------SPEDSEL----ETH----DMFPDTIHSRSHHGPAERT-- CG7097_Dmel LQKYQSPNPQFY--------YYL-DGDE----ESV----AGVPQRIASKMTSRTNGVPAQ ZC404.9_Cele LDKVNGAPTDVYD-RMSKTVDDLTEEESDMDDAPSLLTPDAAPIRIGLPAH--------- KHS_Spur LEKARNVNPGYSP-I-----EDDDDDRL----DEQAL--VNVKKRV-SSKRTDQKDRP-- AqueK230_Aque IRVLEAPSPKPKMSA-----SDPDEEDD----TGARK--ESQMKRISSVKHHNKIDRQ-- AqueK231_Aque MKAFEASST-AS--A-----P-PDDQSD----FEL----GQPRKRIASIARKKTAGQA-- : : : KHS2_Hsap ------------------------RSEITFGQ-----VKFD--PPLR------------- KHS1_Hsap ------------------------ASEINFDK-----LQFE--PPLR------------- HPK1_Hsap ------------------------DADCCRRH-----MEFR--KLRG------------- GCK_Hsap ------------------------PSEIQFHQ-----VKFG--APRR------------- KHS2_Mmus ------------------------RSEINFGQ-----VKFD--PPLR------------- KHS1_Mmus ------------------------ASEINFDK-----LQFE--PPLR------------- HPK1_Mmus ------------------------DADCCRRQ-----MEFQ--RPRC------------- GCK_Mmus ------------------------PSEIQFHQ-----VKFG--APRR------------- CG7097_Dmel NHTLKTGMTTNSTWNERSSSPETLPSDMSLLQYIDEELKLRATLPLNNDTKDPLGAECSC ZC404.9_Cele -----------------------------LNG-----LRL--------D----------- KHS_Spur ------------------------ASEINMDF-----VKKV--K--E------------- AqueK230_Aque ------------------------ISDVAMHG-----LNL---PPKQ------------- AqueK231_Aque ------------------------STLATWLE-----VV--------------------- : KHS2_Hsap ------------------------------------------------------------ KHS1_Hsap ------------------------------------------------------------ HPK1_Hsap ------------------------------------------------------------ GCK_Hsap ------------------------------------------------------------ KHS2_Mmus ------------------------------------------------------------ KHS1_Mmus ------------------------------------------------------------ HPK1_Mmus ------------------------------------------------------------ GCK_Mmus ------------------------------------------------------------ CG7097_Dmel SSHNGGAAGGGGGGGVGVGAGGAAANGSSSSSGGATVGTTHHQHQQHHQHHHHPNHLHQH ZC404.9_Cele ------------------------------------------------------------ KHS_Spur ------------------------------------------------------------ AqueK230_Aque ------------------------------------------------------------ AqueK231_Aque ------------------------------------------------------------ KHS2_Hsap --------KETEPHHELPDS-DGF-LDSSEEIYYTARSNLDLQLEYGQGHQGGYFLGANK KHS1_Hsap --------KETEARDEMGLSSDPN-FMLQ------------------------------- HPK1_Hsap --------METRPPANTARLQPPR-DLR----S--------------------------- GCK_Hsap --------KETDPLNEPWEE-EWT-LLGKEELS--------------------------G KHS2_Mmus --------KETEPHHELPDS-DGF-FDSSEEIYYTARSNLDLQLEYGQGHQSHCFLGGNK KHS1_Mmus --------KETEARDEMGLSSEPN-FILH------------------------------- HPK1_Mmus --------VDCRPQAETVRLYPPA-HFG----S--------------------------- GCK_Mmus --------KETDPLNEPWEE-EWT-LLGKEELS--------------------------G CG7097_Dmel QSHQLPQQQQQQSHQAAQQE-HHHHHPMTSSISS-------------------------G ZC404.9_Cele ----------ARCLEQ-------------------------------------------- KHS_Spur --------VPRMPPDDDGMLGEGN-YQGAHEW-----TPSNA------------------ AqueK230_Aque --------EAQEPISAWLDE-PFH-KPRIQRLS--------------------------- AqueK231_Aque ------------------------------------------------------------ KHS2_Hsap SLLKSVEEEL-HQRGH---V---------------------------AHLE-DDEGDDDE KHS1_Hsap --------------------------------------------------W-NPFVDGAN HPK1_Hsap ---------------S-SPR---------------------------KQLSESSDDDYDD GCK_Hsap SLLQSVQEAL-EERSL-TIR---------------------------SASE-FQELDS-- KHS2_Mmus SLLKSVEEEL-HQRGH---V---------------------------AHLE-DDEGDDDD KHS1_Mmus --------------------------------------------------W-NPFVDGAN HPK1_Mmus ---------------T-SPR---------------------------SQLSD-SDDDYDD GCK_Mmus SLLQSVQEAL-EERSL-TIR---------------------------PALE-LQELDS-- CG7097_Dmel -LVTANANNISSSASL-ASMPGLSAYLGMRSHVVGHMGMGFGMGLGMSNLR-TTSIDADD ZC404.9_Cele -------------------------------------------------LSS-SPNTSSE KHS_Spur -------ETE-GRKGH-Q-T---------------------------NDFK-GAEENTEE AqueK230_Aque ------AEAI-TQYDMTDPE---------------------------YQSVDSIYQSPED AqueK231_Aque -------------------------------------------------------AESN- KHS2_Hsap SKHST----LKAKIPPPLPPK--------------------------------------- KHS1_Hsap TGKST----SKRAIPPPLPPK--------------------------------------- HPK1_Hsap VDIPT----PAEDTPPPLPPK--------------------------------------- GCK_Hsap ------------------------------------------------------------ KHS2_Mmus SKHST----MKAKVPPPLPPK--------------------------------------- KHS1_Mmus TGRST----SKRAIPPPLPPK--------------------------------------- HPK1_Mmus VDIPA----PSENIPPPLPPK--------------------------------------- GCK_Mmus ------------------------------------------------------------ CG7097_Dmel DELVA-ADVAMNNAAAAVPGNGSGAGNGSGSGCSASAAHYLRYSSNYRSAAAAQASQAAH ZC404.9_Cele SD---------RRTPT-ATPR--------------------------------------- KHS_Spur GKHDT-L--PHSDRPPPLPPK--------------------------------------- AqueK230_Aque SLTPPPA--DRTPVAPPVPPR--------------------------------------- AqueK231_Aque ------------------------------------------------------------ KHS2_Hsap PK-SIFIP-QEMH----------------------------------------------- KHS1_Hsap PR-ISSYP-EDNF----------------------------------------------- HPK1_Hsap PK-FRS-P-SDEG----------------------------------------------- GCK_Hsap ------------------------------------------------------------ KHS2_Mmus PK-SIFIP-QDTH----------------------------------------------- KHS1_Mmus PR-VNTYP-EDSL----------------------------------------------- HPK1_Mmus PK-FRS-P-SDDG----------------------------------------------- GCK_Mmus ------------------------------------------------------------ CG7097_Dmel PH-VNSNSNSNNGHGHAPITSSISSSASSASFYNRLLLLDNSSGDAVVGGNGGGSSNISS ZC404.9_Cele SLNRGYHS-ERTL----PA----------------------------------------- KHS_Spur QK-SVKFS-ASNG----------------------------------------------- AqueK230_Aque GT-SSS-R-ISRV----------------------------------------------- AqueK231_Aque ------------------------------------------------------------ KHS2_Hsap --------------------------ST---EDEN--QGTIKRCPMSGSPA-KPSQ-VPP KHS1_Hsap --------------------------P----DEEK--ASTIKHCPDSESR--APQI-LRR HPK1_Hsap --------------------------PGSMGDDGQLSPGVLVRCASGPP----PNS-PRP GCK_Hsap ---------------------------P---DD-T--MGTIKRAPFLGPLPTDPPA-EEP KHS2_Mmus --------------------------SA---EDGN--QGTIKRCPSSGSPA-KPSH-VPP KHS1_Mmus --------------------------P----DEEK--SSTIKRCPDLEAR--APQV-LRR HPK1_Mmus --------------------------SGGIRDDGQLSPGVLVRCASGPP----PRT-PRP GCK_Mmus ---------------------------P---DD-A--IGTIKRAPFLGLPHTESTSGDNA CG7097_Dmel SGGASSGTNGLLDKHELDALPQAATKSA---GDGF--SHSNSPTANSGAGA-TGSR-DND ZC404.9_Cele -----------------KEMP-------LLPDVVG--GDALLHCGNGVIHDDDETL-RAP KHS_Spur --------------------------TA----S-N--ASTRESA--------PPSV-PPS AqueK230_Aque --------------------------PIPLPDDN-NSPHVYGNVGPSNP----------- AqueK231_Aque ----------------------------------------------------DRKG-IKP KHS2_Hsap -RPPPP---------------RLPPHKPV------------------------------- KHS1_Hsap -QSSPS---------------CGPVAETS------------------------------- HPK1_Hsap -GPPPS---------------TSSPHLT-------------------------------- GCK_Hsap LSSPPG---------------TLPPPPS-------------------------------- KHS2_Mmus -RPPPP---------------RLPPQKPA------------------------------- KHS1_Mmus -QSSPS---------------CVPVAETS------------------------------- HPK1_Mmus -GPPPA---------------TCSPHLT-------------------------------- GCK_Mmus QSCSPG---------------TLSAPPA-------------------------------- CG7097_Dmel -GPSSSNSSHLYQNLLRSSSGETPAGSSSAGNNCDYRHENNQNGLEDSPRRHSSMDQLIG ZC404.9_Cele -RAPPR---------------TLRAAQKA------------------------------- KHS_Spur -KPNR------------------PQ---Q------------------------------- AqueK230_Aque ------------------------------------------------------------ AqueK231_Aque TTSPPC---------------TSPVDTTL------------------------------- KHS2_Hsap ------------ALGNGMSS---FQLNGER-DG-SLCQQQNEHRGTNLSRK----EKKDV KHS1_Hsap ------------SIGNGDGI---SKLMSENTEG-SAQ------APQLPRKK----DKRDF HPK1_Hsap ----------------AHSE---PSLWNPPSRE-LDK------PPLLPPKKEKM------ GCK_Hsap --------------------------------G-PNS------SPLLPTAWATMKQREDP KHS2_Mmus ------------VLGNGVNS---FQLNGER-DG-SLYQQQSEQRGTNLSRK----EKKDV KHS1_Mmus -----------SSIGNGDGI---SKLISENTEG-SAQ------APQLPRKK----DKRDF HPK1_Mmus ----------------ARSD---PSLWNPAAPE-PGQ------PPLVPPRKEKMRGKMEN GCK_Mmus --------------------------------G-PGS------PALLPTAWATLKQQEDR CG7097_Dmel LLENMGKSPRTRSLSDGGTQ-DDDEAEKEAQPDLLNN------TPPVPPKRS-HKRRHTP ZC404.9_Cele ------------AAGNSKNRFSSTSIA----------ST----------------PSEDG KHS_Spur -----------QKMMNGRAP---T-TEGENTEDIDNK------PPIVPPRRIRNEFLEPP AqueK230_Aque --------------------------------------------PVPPRNRP-PQETVTP AqueK231_Aque -----------RSIANGGVA-----------------NGGV------------------- KHS2_Hsap PKPISNGLPPTP----------KVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFG KHS1_Hsap PKPAINGLPPTP----------KVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFG HPK1_Hsap ----------------------KRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLG GCK_Hsap ERSSCHGLPPTP----------KVHMGACFSKVFNGCPLRIHAAVTWIHPVTRDQFLVVG KHS2_Mmus PKPISNGLPPTP----------KVHMGACFSKVFNGCPLKIHCATSWINPDTRDQYLIFG KHS1_Mmus PKPTINGLPPTP----------KVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFG HPK1_Mmus ----------EK----------RREKYPLLVKLFNGCPLQIHSTAAWTHPSTKDQNLLLG GCK_Mmus ERSSCHGLPPTP----------KVHMGACFSKVFNGCPLQIHAAVTWVHPVTRDQFLVVG CG7097_Dmel PRPISNGLPPTP----------KVHMGACFSKIFNGCPLRVHCTASWIHPETRDQHLLIG ZC404.9_Cele -LTTFFGMPLIP----------KVPMGACFSKVMDRTELKINCAASWVHPLTGAHLLLFG KHS_Spur PQQASNGLPPTP----------KVTMGACFSKVFNECPLVIHCSASWVHPETRDQYIIFG AqueK230_Aque TNPTPPAVPPRPSSKPSIHKKQSTEGRAYFSKIFNGCPLKLHCATSWTHPHNQNYYVLLG AqueK231_Aque ----------------------EERGRACFTKIFKGCPLQVHCAGSWIHPIREVLFVLLG . : *::. * ::.: :* :* ::.* KHS2_Hsap AEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSIS-GKASQLYSHNLPGLFDYAR KHS1_Hsap TEDGIYTLNLNELHEATMEQLFPRKCTWLYVINNTLMSLSVGKTFQLYSHNLIALFEHAK HPK1_Hsap AEEGIFILNRND-QEATLEMLFPSRTTWVYSINNVLMSLS-GKTPHLYSHSILGLLERKE GCK_Hsap AEEGIYTLNLHELHEDTLEKLISHRCSWLYCVNNVLLSLS-GKSTHIWAHDLPGLFEQRR KHS2_Mmus AEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSVS-GKASQLYSHNLPGLFDYAR KHS1_Mmus TEDGIYTLNLNELHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEQAK HPK1_Mmus AEEGIFILNRND-QEATLEMIFPGRTTWLYCINNLLMSLS-GKTPYLYSHSILGLLERKD GCK_Mmus AEEGIYTLNLHELHEDTMEKLISQRCSWLYCVNNVLLSLS-GKSTHIWAHDLPGLFEQRR CG7097_Dmel AEEGIYNLNMNELHDAAIDQLFPRRTTWLYVIKDVLMSLS-GKSCQLYRHDLVALHSKQT ZC404.9_Cele TEQGIYSFDTNCMPDGNLSKIHHRRCSWMFVYADRLTAIQ-GNTPYVYRHDLVALTQKNL KHS_Spur CDEGIYMFNLTQIHEGAMDQMFPRKTTWLYIINNIMMSLS-GKNPSIYQHNLVALVDKNP AqueK230_Aque AEEGLFSLQANTQQDPVMEQVSPRSCHWLRVVENVLIWLS-GTNHMISMTNLIQLFQSES AqueK231_Aque TQEGLFYLQVNREGDPIIEQVDSDH---MISM-----------------TNLILLFQNEQ ::*:: :: : :. : : .: * . KHS2_Hsap QMQKLPV--AIPAHKLPDR-ILPRKFSVSAKIPETKWCQKCCVVRNP--YTGHKYLCGAL KHS1_Hsap K-PGLAA--HIQTHRFPDR-ILPRKFALTTKIPDTKGCHKCCIVRNP--YTGHKYLCGAL HPK1_Hsap TRAGNP-----IAHISPHR-LLARKNMVSTKIQDTKGCRACCVAEGA--SSGGPFLCGAL GCK_Hsap LQQQVPL--SIPTNRLTQR-IIPRRFALSTKIPDTKGCLQCRVVRNP--YTGATFLLAAL KHS2_Mmus QMQKLPV--AIPAHKLPDR-ILPRKFAVSAKIPETKWCQKCCVVRNP--YTGHKYLCGAL KHS1_Mmus K-PGLAA--HIQTHRFPDR-ILPRKFALTTKIPDTKGCHKCCIVRNP--YTGHKYLCGAL HPK1_Mmus GRTGSP-----IAHISPHR-LLARKNMVSSKIQDTKGCRACCVAESA--SSGGPFLCGAL GCK_Mmus LQHQAPL--SIPTNRITQR-IIPRRFALSTKIPDTKGCLQCRVVRNP--YTGSTFLLAAL CG7097_Dmel V----RF--SLHMNKIPER-LVPRKFALTTKVPDTKCCTQCCVTRNP--YNGYKYLCGAT ZC404.9_Cele T---LKM--SKNLNKIPEK-YVPKRLAITVRMPETRGALQCTVKRGQGAQANSLFLCCAV KHS_Spur HRFHMPSRFGEKLQRIPDK-LVPRKFALSHKVPDTKGCTKCCVVRNP--YNSHKYLCGAL AqueK230_Aque QKA--PG---------------HRNRSHTSKIHDSKGCYKCSIARNP--FSDQRYLLAAV AqueK231_Aque EIAARRG--GGGGGKDGETFRRNRRIRHSSKIKDSIGCFKCSIVVNP--YNKEKYLIAAV :. : :: :: . * : . :* * KHS2_Hsap QTSIVLLEWVEPMQKFMLIKHI--DFPIPC------------PLRMFEMLVV-PEQEYPL KHS1_Hsap QSGIVLLQWYEPMQKFMLIKHF--DFPLPS------------PLNVFEMLVI-PEQEYPM HPK1_Hsap ETSVVLLQWYQPMNKFLLVRQV--LFPLPT------------PLSVFALLTG-PGSELPA GCK_Hsap PTSLLLLQWYEPLQKFLLLKNF--SSPLPS------------PAGMLEPLVL-DGKELPQ KHS2_Mmus QTSIVLLEWVEPMQKFMLIKHI--EFPMPC------------PLRMFEMLVV-PEQEYPL KHS1_Mmus QSGIVLLQWYEPMQKFMLIKHF--DFPLPS------------PLNVFEMLVI-PEQEYPM HPK1_Mmus ETSVVLLQWYQPMNKFLLVRQV--LFPLPT------------PLPVFTLLTT-PGSELPA GCK_Mmus PASLLLLQWYEPLQKFLLLKNF--SSPLPS------------PAGMLEPLVL-DGKELPQ CG7097_Dmel PSGIFLMQWYDPLNKFMLLKQC--EWPAISIQGGGHGCVQNGHTPVFEMIIT-PELEYPI ZC404.9_Cele RKTVHLFQWYNPMNQFVLVRSEPIREDIRF------------PIRPFALINS-RTSDFPE KHS_Spur PAGVVLLQWYEPMNKFLQVKVF--DCPLPP------------EIKVFEMLIK-PDAEFPI AqueK230_Aque PKGILVMQWYQPRHAFMHVKLF--ECSLPS------------PLNMFEAFVI-ENDEYPS AqueK231_Aque PKGILLMQWYQISHAFMLVKLF--ECSLPS------------PLVLFEAFVLTQEDEYPT : :::* : : *: :: : : : * KHS2_Hsap VCVGVSRGRDFNQVVRFETVNPNSTSSWFTES------------DTPQTNVTHVTQLERD KHS1_Hsap VCVAISKGTESNQVVQFETINLNSASSWFTEIG----------AGSQQLDSIHVTQLERD HPK1_Hsap VCIGVSPGRPGK-SVLFHTVRFGALSCWLGEM------------STEHRGPVQVTQVEED GCK_Hsap VCVGAEGPEGPGCRVLFHVLPLEAGLTPDILIP----------PEGIPGSAQQVIQVDRD KHS2_Mmus VCVGVSRGRDFNQVVRFETVNPNSTSSWFTES------------DAPQTSVTHVTQLERD KHS1_Mmus VCVAISKGSDSSQVVQFETINLNSASSWFTEIG----------AGSQQLDSIHVTQLERD HPK1_Mmus VCIGVSPGQAAK-SVLFHTVRFGALSCWLDDS------------STEHKGPVQVIQVKED GCK_Mmus VCVGAEGPEGPGCRVLFHVLPLEAGLTPDILIP----------PEGIPGSAQQVIQVDRD CG7097_Dmel VCTGVRKAMN-G-CLKLELINMNSAS-WFHSEDLEYDAMATMVPRRDLLKVVRVHQVEKD ZC404.9_Cele LCIGVGQMSGSN-EYQFNMINFCSSTNN-SELSGDLNSSYGSLADDEMLEVGSMHQIDRD KHS_Spur VCVGVARGLDRS-HLTFDVVNLNSTSSWFVEHP----------PTEKLLDVVCVSQIERD AqueK230_Aque VCVGVRESEG-G-NVQFNAININSNSCWFDSF------------S--NDEIIELQQLEKD AqueK231_Aque ICVGVNTSTG-D-NVLFNTISLNPSSSSITV--------------SHNSDITKLEQVEKD :* . :. : . : *:..* KHS2_Hsap TILVCLD----CCIKIVNLQGRLKS-SRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQG KHS1_Hsap TVLVCLD----KFVKIVNLQGKLKS-SKKLASELSFDFRIESVVCLQDSVLAFWKHGMQG HPK1_Hsap MVMVLMD----GSVKLVTPEGSPVR-GL-RTPEIPMTEAVEAVAMVGGQLQAFWKHGVQV GCK_Hsap TILVSFE----RCVRIVNMQGEPT---ATLAPELTFDFPIETVVCLQDSVLAFWSHGMQG KHS2_Mmus TILVCLD----CCIKIVNLQGRLKS-SRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQG KHS1_Mmus TVLVCLD----KFVKIVNLQGKLKS-SKKLASELSFDFRIESVVCLQDSVLAFWKHGMQG HPK1_Mmus MVMVLMD----GSLKLVTPEGAPAP-GL-RTPEIPMTEAVEAVAMVEDRLEAFWKHGVQV GCK_Mmus TVLVSFE----RCVRIVNLQGEPT---AALAPELTFDFTIETVVCLQDSVLAFWSHGMQG CG7097_Dmel AILVCYG----NLIQVVTLQGNPKQ-HKKMVSQLNFDFNVDSIVCLPDSVLAFHKHGMQG ZC404.9_Cele TLCFSFR----NKVVLTDLQGFERP-K---PSIFTFNFHIEYLHVVDGTILAFHANGVQG KHS_Spur TVLVCFD----SEVKVVNLNGRPRN-SKKLLTELHFDFAVDKLVVLQDSVLAFHRHGMQG AqueK230_Aque TIFVASQ----FCAKFVDLNGTMKP-SGKQASQIYFDKKTESMVYLQNCVLSFHKHGMQG AqueK231_Aque TILILDSRILTYCAKFVDISGSLKAPEEKMASSLYFDK--ESVM-----MGSFNDHGLQG : . .. .* . : : : : : :* :*:* KHS2_Hsap RSFRSNEVTQEISDSTRIFRLLGSDRVVVLESRPTDNPT-------------ANSNLYIL KHS1_Hsap KSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPT-------------AHSNLYIL HPK1_Hsap WALGSDQLLQELRDPTLTFRLLGSPRL---ECSGTISPHCNLLLPGSSNSPASASRVAG- GCK_Hsap RSLDTNEVTQEITDETRIFRVLGAHRDIILESIPTDNPE-------------AHSNLYIL KHS2_Mmus RSFRSNEVTQEISDNTRIFRLLGSDRVVVLESRPTDNPT-------------ANSNLYIL KHS1_Mmus KSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPA-------------AHSNLYIL HPK1_Mmus WAPGLKQPLQELRDPTLTFRLLCSPRPVVVETRPTDDP-------------TAPSNLYI- GCK_Mmus RSLDTNEVTQEITDETRIFRVLGAHRDIILESIPTDNPG-------------AHSNLYIL CG7097_Dmel KSLRNGEVTQEIKDMSRTYRLLGSDKVVALESQLLRTGS---------LGSEEGHDLYIL ZC404.9_Cele RDLKSNLNTQDLCDVSRLYRVIGDDRVIILRSQPMSPR-----------NSGDTCDVSLL KHS_Spur RSFRSNEVTQEICDKSKLFTLLGHEKLTVLKSHPLSDPT-------------APCNIYLL AqueK230_Aque KSLITQQVTAEVADSSKVFHLLGSHGTIIIETKQADDAS-------------GPSNLYIL AqueK231_Aque KSLLTEQVTAEVIDHSKKFKLLCSDGTIIVETKRADNPS-------------YPSSLYLL :: * : : :: . : KHS2_Hsap AG----HEN---SY KHS1_Hsap AG----HEN---SY HPK1_Hsap -------IT---GL GCK_Hsap TG----HQS---TY KHS2_Mmus AG----HEN---SY KHS1_Mmus AG----HEN---SY HPK1_Mmus ------------QE GCK_Mmus TG----HQS---SY CG7097_Dmel AG----HEA---SY ZC404.9_Cele MG----HTDTPIAG KHS_Spur TG----HAN---MM AqueK230_Aque VSEEAYHVH---SQ AqueK231_Aque ES----E-E---AT