CLUSTAL W (1.83) multiple sequence alignment LATS1_Hsap MKRSEKPEGYRQMRPKTFPAS-NYTVSSRQMLQEIRESL-----RNLSKPS--------- LATS2_Hsap M------------RPKTFPAT-TYSGNSRQRLQEIREGL-----KQPSKSSVQGL---PA T20F10.1_Cele MR------------PAA-PGT-TPNGASSDIRHQRG-V-APIP---FG------------ wts_Dmel MHPAGEKRGG-------RPND-KYTA---EALESIKQDL-----TRF------------- LATS_Spur MQQYHH------QQPSPIPYD-EESGAKVSQISRLYQQQQPKGPDSPDSSIRDGS---SY AqueK010_Aque MSSRESKDRK-VRKPAVGSSSQSSTAGNEQVLQGIRVNL-----AASRKSVTPSPVRETA AqueK011_Aque MVKLP---------PNSSPL-NFK------------------------------------ LATS2_Mmus M------------RPKTFPAT-TYSGNSRQRLQEIREGL-----KQPSKASTQGL---LV LATS1_Mmus MKRGEKPEGYRQMRPKTFPAS-NYPGSSRQMLQEIRESL-----RNLSKPS--------- * . LATS1_Hsap ----DAA-----------KAEHNMSKMSTEDPRQ------------VRNPPKFGTH---- LATS2_Hsap GPNSDTS----------LDAKVLGSKDATRQQQQ------------MRATPKFGPY---- T20F10.1_Cele --STNSA----------IDAH-------------------------HNSEIRVGRH---- wts_Dmel --------------------EVQNNHRNNQNYTP------------LRYTATNGRN---- LATS_Spur ASSTDSSSLSNGSGYRTVPAPHGFKRKSSYDDRGQPLLQSNAAGDALQHPSPYGQQTSRQ AqueK010_Aque TP-SPVTL---------VESSSPGSSRVKSRPSP------------VESERQRHRH---- AqueK011_Aque ------------------------------------------------------------ LATS2_Mmus GPNSDTS----------LDAKVLGSKDAS-RQQQ------------MRATPKFGPY---- LATS1_Mmus ----DAS-----------KAEHNLNKMSTEDPRQ------------VRNPPKFGTH---- LATS1_Hsap -------------------------------------------HKALQEIRNSLLPFAN- LATS2_Hsap -------------------------------------------QKALREIRYSLLPFAN- T20F10.1_Cele -------------------------------------------RAKLDEIRESLKAYEH- wts_Dmel -------------------------------------------DALTPDYHHAKQPMEP- LATS_Spur QIHLGGGSDNTRSLSSISSNNSFSDGRSSSIQQQQQAAYPGRSYTSIMAAGDNLAPNSQG AqueK010_Aque -------------------------------------------GEQMARIRDNLKPHHKS AqueK011_Aque ------------------------------------------------------------ LATS2_Mmus -------------------------------------------QKALREIRYSLLPFAN- LATS1_Mmus -------------------------------------------HKALQEIRNSLLPFAN- LATS1_Hsap ET----------------NSSRS-TSEVNPQMLQDLQAAGFDE----------DMVIQ-- LATS2_Hsap ES----------------GTSA--AAEVNRQMLQELVNAGCDQ----------EMAGR-- T20F10.1_Cele EAGLLSSHVALGSLATPSSSSVS-HSDITNDNA-E------------------------- wts_Dmel PP----------------SASPA-PDVVIPP-PPA------------------------- LATS_Spur MP-----------FA---GSVAPGGDSRLQTQWNTMNYSGYPAHSRDSSGQIHITAGRAP AqueK010_Aque DP----------------GFNYP-PDAVDQDMLHELIMKGYDQ----------NSCIA-- AqueK011_Aque ---------------------------------------------------------A-- LATS2_Mmus ES----------------GTSA--AAEVNRQMLQELVNAGCDQ----------EMAGR-- LATS1_Mmus ET----------------SSSRS-PSEVNPQMFQDLQAAGFDE----------DMVIQ-- LATS1_Hsap --ALQKTN-NRSIEAAIEF--IS-----------KMSYQDPRREQMAAAAARPINA-SMK LATS2_Hsap --ALKQTG-SRSIEAALEY--IS-----------KMGYLDPRNEQIVRV----IKQTSPG T20F10.1_Cele --VMNFS---------------S-----------SSSN---------AA---ATT-TTVS wts_Dmel --IVGQPG-AGSISVSGVG--VG-----------VVGVANGRVPK-------------MM LATS_Spur PNNLQSTNHNRSVPSM-ERTKVANMLHIGNNGDIYQSYVNPKRDNSGYV----------- AqueK010_Aque --ALIQCN-SHSVEAALDV--LM-----------SGKRSTPISTT-------------SS AqueK011_Aque --YLLRMR-IRSIKIKVDL--VI-----------K------------------------- LATS2_Mmus --ALKQTG-SRSIEAALEY--IS-----------KMGYLDPRNEQIVRV----IKQTSPG LATS1_Mmus --ALQKTN-NRSIEAAVEF--IS-----------KMSYQDPRREQMSAAAARPINA-TMK : LATS1_Hsap PGNVQQSVNRKQSWKGSKESL--VPQ-RHGPP-LGES-VA-------YHSESPNSQTDVG LATS2_Hsap KGLMPTPVTRRPSFEGTGDSF--ASYHQLSGT-PYEG-PSFGADGPTALEEMPRPYVDYL T20F10.1_Cele SAAVSNSNSFRTEGGGHKMRITPMPQ-RHLMMDTGANETVFRSGKEMIRNGNPS------ wts_Dmel TALMPNKLIRKPSIERDTASS--HYL-RCSPA-LDSG-A------GSSRSDSPHSHHT-H LATS_Spur ------------------SSL--TM-SRVPGP-ADSG-YN-------QITINPEDRTIKR AqueK010_Aque TGL---------------SS---------------------------------------- AqueK011_Aque ------------------------------------------------------------ LATS2_Mmus KGLAPTPVTRRPSFEGTGEAL--PSYHQLGGA-NYEG-PA-------ALEEMPRQYLDFL LATS1_Mmus PGNVQHSINRKQSWKGSKESL--VPQ-RHGPS-LGEN-VV-------YRSESPNSQADVG LATS1_Hsap RP------LSGSGI-SA--FVQAHPSNGQRVNPPPP-P---------------------- LATS2_Hsap FP------GVGPHG-PG--HQHQHPPKGYGASVEAAGA-H-FPLQ-GAHYGRPHLLVPGE T20F10.1_Cele ---TTISSTPSTTT-E--ESIRIHP-AGYRYDMPTP-AY--------------------- wts_Dmel QP------SS-R--------TVGNP-GGNGGFSPSP-S---------------------- LATS_Spur QTVITISTTSSTTYSTGKQFTVSD-PMSSHNPPPYP-QGRTYNVQAATAAAQGQSIP--Q AqueK010_Aque --------------------IRE-T-SGYHPHPPPP-Q---------------------- AqueK011_Aque ------------------------------------------------------------ LATS2_Mmus FP------GAGAGT-HGA-QAHQHPPKGYSTAVEPS-A-H-FP---GTHYGRGHLLS--E LATS1_Mmus RP------LSGSGI-AA--FAQAHPSNGQRVNPPPP-P---------------------- LATS1_Hsap ------------------------------------------------------------ LATS2_Hsap PLGYG--------------VQ---RS---------------------------------- T20F10.1_Cele ------------------------------------------------------------ wts_Dmel ------------------------------------------------------------ LATS_Spur SNGYDLGQRHGTMTNATYSVQSTQVSSQLAAQHNPQAGSNVTYNGQSPNMSNHLNVQHGS AqueK010_Aque ------------------------------------------------------------ AqueK011_Aque ------------------------------------------------------------ LATS2_Mmus QPGYG--------------VQ---RS---------------------------------- LATS1_Mmus ------------------------------------------------------------ LATS1_Hsap ---------QVRSVTPPPP-PRG----QTPPPRGTTPPPPSWEPNSQ--TKRYSGNMEYV LATS2_Hsap --------PSFQSKTPPET-GGY----ASLPTKGQGGPPG-------------------- T20F10.1_Cele ---------HMNNNAPQYS-PG-----------YSRPPPPAYDSSP--VNTRM------- wts_Dmel ---------GFSEVAPPAPPPRN----PTACS-AATPPPPV-PPTSQAYVKRRSPALNNR LATS_Spur TSKEQHRSSAHIMILPPDNQPNMYSQDMISAMISKTQPPPSYEFSTQ--HRQTPNSIQTQ AqueK010_Aque ---------Y-QTSLDN------------------------------------------- AqueK011_Aque ------------------------------------------------------------ LATS2_Mmus --------SSFQNKTPPDA---Y----S-SMAKAQGGPPA-------------------- LATS1_Mmus ---------QVRSVTPPPP-PRG----QTPPPRGTTPPPPSWEPSSQ--TKRYSGNMEYV LATS1_Hsap ISRISPVPPGAWQEGYPPPPLNTSPMNPPNQGQRGISSVPVGRQPIIMQSSSKFNFPSGR LATS2_Hsap ----------AGL-AFPPPAAGLYVP-HPHHK---------------------------- T20F10.1_Cele ----TPVAT--------------------------------------------------- wts_Dmel PPAI---AP-PTQRGNSPVITQNGLKNPQQQLTQQLKSLN-------------------- LATS_Spur AGHI---GG-QQQR---------------------------------------------- AqueK010_Aque -----------------------SDLLPNHFETTSTSSLP-------------------- AqueK011_Aque ------------------------------------------------------------ LATS2_Mmus -----------SL-TFPA-HAGLYTA-S-HHK---------------------------- LATS1_Mmus ISRISPVPPGAWQEGYPPPPLTTSPMNPPSQAQRAISSVPVGRQPIIMQSTSKFNFTPGR LATS1_Hsap PGMQNGTGQTDFMIHQNVVPAGT--VNRQPPP-PYPLTAANGQSPSALQTGGSAAPSSYT LATS2_Hsap -------------------------QA--GPA-A-----------HQLHVLGSRS-QVFA T20F10.1_Cele ---------DNYRTHLH-MKVHP--VVKAPPPNPTMLNHNKNMAP---------PPPPPA wts_Dmel -----------------LYPGGGSGAVVEPPP-PYLIQGGAGG---------AAPPPP-- LATS_Spur --------------------------------------------------GGT---PTMT AqueK010_Aque --------------GQ-SFTKHS--VTMDPYP-PTLITRD-------------------- AqueK011_Aque ------------------------------------------------------------ LATS2_Mmus -------------------------PAATPPG-A-----------HPLHVLGTRG-PTFT LATS1_Mmus PGVQNGGGQSDFIVHQN-VPTGS--VTRQPPP-PYPLTPANGQSPSALQTGASAAPPSFA LATS1_Hsap NGSIPQSMMVPNRNSHNME------------LYNISVPGLQTNWPQSSS--------A-- LATS2_Hsap SDSPPQSLLTPSRNSLNVD------------LYELGSTSVQ-QWPAATL--------A-- T20F10.1_Cele KSTISIETMSEERKADNIQR-----------LYHTSMDK------KTA-S-------S-- wts_Dmel -------------------------------------PPSYTASMQSRQ--------S-- LATS_Spur QQQFNTARLTPQ-NSQNPSNSSTVFKPIPSQMGGGNVVQIQTQLPQHHQPQPAVVTISRI AqueK010_Aque -------------------------------------------L---------------- AqueK011_Aque ------------------------------------------------------------ LATS2_Mmus GESSAQAVLAPSRNSLNAD------------LYELGSTV---PWSAAPL--------A-- LATS1_Mmus NGNVPQSMMVPNRNSHNME------------LYNINVPGLQTAWPQSSS--------A-- LATS1_Hsap -PAQSSPSSGHEIP-----TWQPNI--PVRSNSFN-----NP--LGNRASHSANSQPSAT LATS2_Hsap -RRDSLQKPGLEAPPRAHVAFRPDCPVPSRTNSFN-----SHQPRPGPPGKAEPSLPAPN T20F10.1_Cele -VVSINVASPHTTK-----VNVGDSP--LPSKSF-------I--IGPRYTADVDRKNFVN wts_Dmel -PTQSQQSDYRKSP------------------------------SSGIYSATSAGSPSPI LATS_Spur DPNNDLTGGSKPPP-----PYRPAA--PVQSVEMKTKDLHLKVPVPVPAAVSSTALPGPG AqueK010_Aque -------SPIH-----------------------------------SSPDH--------- AqueK011_Aque ------------------------------------------------------------ LATS2_Mmus -RRDSLQKQGLEA-SRPHVAFRA---GPSRTNSFN-----NPQP--------EPSLPAPN LATS1_Mmus -PAQSSPSGGHEIP-----TWQPNI--PVRSNSFN-----NP--LGSRASHSANSQPSAT LATS1_Hsap TV---------------TAITP-APIQQPVKSMRVLKPELQTALAPTHPSWIPQP---IQ LATS2_Hsap TV---------------TAVTA-AHILHPVKSVRVLRPEPQTAVGPSHPAWVPAP---AP T20F10.1_Cele YK---------------DE----------------LRPDP-------------------- wts_Dmel TVSLPPAPLAKPQPRVYQARSQQPIIMQSVKSTQVQKPVLQTAVAPQSPSSASASNSPVH LATS_Spur -------------------YSS-PPILQSVRSTTVAKPVLQKAHGPDQPPPARGS-SPDT AqueK010_Aque ------SPHGTPPP-----------------------------------------ESKRH AqueK011_Aque -----------------------------------------KVVGVASPD---------- LATS2_Mmus TV---------------TAVTA-AHILHPVKSVRVLRPEPQTAVGPSHPAWVAAP---TA LATS1_Mmus TV---------------TAITP-APIQQPVKSMRVLKPELQTALAPTHPSWMPQP---VQ LATS1_Hsap TV-QPSPFPE------------------------GTASNVTVMPPVAE------------ LATS2_Hsap AP-APAPAPAAEGLDAKEEHALA----------LGGAGAFPLDVEY-G------------ T20F10.1_Cele -----RLIPSTSDANHEDFRPIL---------------FKPRNLEI-T------------ wts_Dmel VLAAPPSYPQKSAAVVQQQQQAAAAAHQQQHQHQQSKPPTPTTPPLVGLNSKPNCLEPPS LATS_Spur VS-T-------QSTSTQS---------------SSTRSESP------------------- AqueK010_Aque VHVSPP--------------------------------PD-VQPR---------TYSPFS AqueK011_Aque ------------------------------------------------------------ LATS2_Mmus PA--T------ESLETKE----------------GSAGPHPLDVDY-G------------ LATS1_Mmus TV-QPTPFSE------------------------GTASSVPVIPPVAE------------ LATS1_Hsap ------------------------------------------------------------ LATS2_Hsap ------------------------------------------------------------ T20F10.1_Cele ------------------------------------------------------------ wts_Dmel YAKSMQAKAATVVQQQQQQQQQQQQVQQQQVQQQQQQQQQQLQALRVLQAQAQRERDQRE LATS_Spur ------------------------------------------------------------ AqueK010_Aque AP---------------------------------------------------------- AqueK011_Aque ------------------------------------------------------------ LATS2_Mmus ------------------------------------------------------------ LATS1_Mmus ------------------------------------------------------------ LATS1_Hsap ----------------APNY-QGPPPP-YPKHLLHQNPSVPPYES-----ISKPSKEDQP LATS2_Hsap ----------------GPDR-RCPPPP-YPKHLLLRSKSEQY--D-----LDSLCAGMEQ T20F10.1_Cele ----------------MKSR-AQPPPPQYNQ------PSEPPPKR-----V--------- wts_Dmel RDQRERERDQQKLANGNPGRQMLPPPP-YQSNNNNNSEIKPPSCNNNNIQISNSNLATTP LATS_Spur -------------------------LV-RPPSLISEI----------------------- AqueK010_Aque -----------------FSRQMQTPPV-YDRNARLPHG-------------------YSP AqueK011_Aque ------------------------------------------------------------ LATS2_Mmus ----------------GSER-RCPPPP-YPKHLLLPSKSEQYSVD-----LDSLCTSVQQ LATS1_Mmus ----------------APSY-QGPPPP-YPKHLLHQNPSVPPYES-----VSKPCKDEQP LATS1_Hsap S----------------LPKEDESEKSYENVDSGDKEKKQITTSPITVRKN---KKDEER LATS2_Hsap SL----------RAGPNEPEGGDKSRKSAKGDKGGKDKKQIQTSPVPVRKN---SRDEEK T20F10.1_Cele ------------------------------------------SSPID-RTL---LEPYIK wts_Dmel PIPPAKYNNNSSNTGANSSGGSNGST-GTTASSSTSCKKIKHASPIPERKKISKEKEEER LATS_Spur --------------------SDVGDLESASSDSQPLEKSRI-ESPVPERRNK--GRHKER AqueK010_Aque IIRPAS----------------------ELS---------------------DS-GIEEE AqueK011_Aque ------------------------------------------------------------ LATS2_Mmus SL----------RGGTE-QDRSDKSHKGAKGDKAGRDKKQIQTSPVPVRKN---SRDEEK LATS1_Mmus S----------------LPKEDDSEKSADSGDSGDKEKKQITTSPITVRKN---KKDEER LATS1_Hsap RESRIQSYSPQAFKFFMEQHVENVLKSHQQRLHRKKQLENEMMRVGLSQDAQDQMRKMLC LATS2_Hsap RESRIKSYSPYAFKFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEAEQEQMRKILY T20F10.1_Cele NTRRVQPCKPNMLRFYMEQHVERLLQQYKEREKRMKQLEKEMVSAQLPDIMRNKMLGLLQ wts_Dmel KEFRIRQYSPQAFKFFMEQHIENVIKSYRQRTYRKNQLEKEMHKVGLPDQTQIEMRKMLN LATS_Spur YEPRVKTYNPQAYKFYMEQHVENILKSHRQRITRRMQLEQEMQRVDLTSGDRDQMRRMLF AqueK010_Aque TAPQRNPVPPEAFKFYMEQHIENVLKAYQQRQQRRMKLEVEMGKRGLDEATCEQMRKLLA AqueK011_Aque -------------------HTPRLPYVYLSIPFKWKKLEQSMSELELADEEREERRKQHA LATS2_Mmus RESRIKSYSPYAFKFFMEQHVENVIKTYQQKVSRRLQLEQEMAKAGLCEAEQEQMRKILY LATS1_Mmus RESRIQSYSPQAFKFFMEQHVENVLKSHQQRLHRKKQLENEMMRVGLSQDAQDQMRKMLC * .: : . : :** .* * . : LATS1_Hsap QKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDT-KALYATKTLRKKDVLLRN LATS2_Hsap QKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVCLACKVDT-HALYAMKTLRKKDVLNRN T20F10.1_Cele QKESKYTRLRRQKMSKSHFTVISHIGVGAFGKVSLVRKNDT-RKVYAMKSLEKADVIMKQ wts_Dmel QKESNYIRLKRAKMDKSMFVKLKPIGVGAFGEVTLVSKIDTSNHLYAMKTLRKADVLKRN LATS_Spur QKESNYLRLKRAKMNKSMFKKIKTLGIGAFGEVALARKVDT-NALYAVKKLRKLDVIQRN AqueK010_Aque QKESNFLRMKRAKMHRDQFDIVKPIGVGAFGVVSLVRKKDT-RRLYAMKSLRKADVVRRN AqueK011_Aque QKETQFLRLRRSRLGKKDFKRLKIIGRGAFGEVVLVQKIDT-GHVYAMKVLRKSDMVEKE LATS2_Mmus QKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVCLACKLDT-HALYAMKTLRKKDVLNRN LATS1_Mmus QKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDT-KALYATKTLRKKDVLLRN ***::: *::* :: :. * :. :* **** * *. * ** :** * *.* *:: :: LATS1_Hsap QVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLA LATS2_Hsap QVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLA T20F10.1_Cele QAAHVKAERDILAEADSPWIVRLFFSFQDDACLYFIMEYVPGGDMMTLLIQKGIFEEDLA wts_Dmel QVAHVKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIKLGIFEEELA LATS_Spur QAGHVKAERDILAEADNEWVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIRLEIFEEDLA AqueK010_Aque QVAHVKAERDILAEADNEWVVKLYYSFQDAECLYFVMEYIPGGDMMSLLIKLGTFPEHLT AqueK011_Aque QIAHARAERDILVEADNPWVVKMYYSFQDAINLYFIMEFLPGGDMMTLLMKKDILSEDVT LATS2_Mmus QVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLA LATS1_Mmus QVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPENLA * .*.:******.***. *:*::::**** ***:*:::****:*:**:: : * :: LATS1_Hsap RFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQS- LATS2_Hsap RFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQK- T20F10.1_Cele RFYIAELACAIEYVHNVGFIHRDLKPDNILIDQHGHIKLTDFGLCTGLRWTHDRRYYGPE wts_Dmel RFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHNSKYYQEN LATS_Spur RFYIAELVLAIESVHKMDFIHRDIKPDNILVDRDGHIKLTDFGLCTGFRWTHDSKYYQK- AqueK010_Aque LFYIAELVCAIESVHKMGFIHRDIKPDNILIEADGHIKLTDFGLCTGFRWTHDSKRYQPK AqueK011_Aque RFYIAESILAVDSIHKMSFIHRDIKPDNLLLDSRGHIKLSDFGLCTGLKIAHRTEFYRD- LATS2_Mmus RFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQK- LATS1_Mmus RFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQS- ***** *:: :*::.*****:****:*:: *****:*******:: :* . * LATS1_Hsap G--DHP----RQDSMDFSN-EWGDPSSCRCG-----------------DRLKPLERRAAR LATS2_Hsap G--SHV----RQDSMEPSD-LWDDVSNCRCG-----------------DRLKTLEQRARK T20F10.1_Cele N--DHH----RVDSFSLPP-EVAA-----ID-----------------KSVKVLNVR--Q wts_Dmel G--NHS----RQDSMEPWE-EYSE---N--G-----------------PKPTVLERRRMR LATS_Spur S--GHA----RQDSMEPFD-TM-DGEKCKCINHFAHKEKELDLSSLDKRPLKTLERRRKR AqueK010_Aque GSSGHT----RQGSIEPDTSAWGDQ--C--T-----------------CPMKPLEIRRLK AqueK011_Aque L--SNVDLSDPQDSRRFS-QT-------------------------------------WK LATS2_Mmus G--NHM----RQDSMEPGD-LWDDVSNCRCG-----------------DRLKTLEQRAQK LATS1_Mmus G--DHP----RQDSMDFSN-EWGDPSNCRCG-----------------DRLKPLERRAAR .: .* : LATS1_Hsap QHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQM LATS2_Hsap QHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQL T20F10.1_Cele QTRRITAHSLVGTGNYMAPEVIAKTGHNQSCDWWSTGVILYEMVFGRVPFHDDTPGGTQH wts_Dmel DHQRVLAHSLVGTPNYIAPEVLERSGYTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQ LATS_Spur QQERCKAHSLVGTPNYIAPEVLTRTGYTQLCDWWSVGVILYEMLVGQPPFHADSPAETQW AqueK010_Aque EHHRCVAHSLVGTPNYIAPEILRRVGYTQLCDWWSVGVIMYEMLVGQPPFMASAPADTQL AqueK011_Aque KTRRDRAFSTVGTPDYIAPEVFMQTGYTHLCDYWSLGVIMYEMLMGFPPFCSEKPQDTYR LATS2_Mmus QHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQL LATS1_Mmus QHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQM . .* *.* *** :*:***:: : *:.: **:** ***::**:.* ** * * LATS1_Hsap KVINWQTSLHI-PPQAKLSPEASDLIIKLCRGPEDRLGKNGAD------EIKAHPFFKT- LATS2_Hsap KVINWENTLHI-PAQVKLSPEARDLITKLCCSADHRLGRNGAD------DLKAHPFFSA- T20F10.1_Cele RIKNWRNFLDF-TYCGNLSKECLMMIQQLICDASSRLGSHGKDVAERTAQVKNHPWFRG- wts_Dmel KVINWEKTLHI-PPQAELSREATDLIRRLCASADKRLGKS-VD------EVKSHDFFKG- LATS_Spur KVINWKQCLHI-PSQAKLSRDASDFILRLCTGPEERLGKNGVL------DIKSHPFFQT- AqueK010_Aque KIVNWPEYLRI-PHHAQLSTAARDLVLRFLSDPQDRIGRNGAD------EIKHHPFFTSR AqueK011_Aque KIMNWRQHLIFSPELPTISKDAESLIRSLLCDSQHRLGQD-VE------EIKRQPFFRG- LATS2_Mmus KVINWESTLHI-PTQVRLSAEARDLITKLCCAADCRLGRDGAD------DLKAHPFFNT- LATS1_Mmus KVINWQTSLHI-PPQAKLSPEASDLIIKLCRGPEDRLGKNGAD------EIKAHPFFKT- :: ** * : . :* . :: : .. *:* ::* : :* LATS1_Hsap IDFSSDLRQQSAS--YIPKITHPTDTSNFDPVDPDKLWSDDNEEE-NVNDTLNG-WYKNG LATS2_Hsap IDFSSDIRKQPAP--YVPTISHPMDTSNFDPVDEESPWNDASEGSTKAWDTLTS---PNN T20F10.1_Cele IDWV-NLRKLRADYIYIPRVTHDEDTSNFETFQDNDRA--------------DKP--NVR wts_Dmel IDFA-DMRKQKAP--YIPEIKHPTDTSNFDPVDPEKLRSNDSTMS-SGDD--V----DQN LATS_Spur IDLDSNIRKMKAP--YIPTVRHPTDTSNFDPVSPNKLGSDSSTDS---WDSNPNEEENHR AqueK010_Aque IDWDVGIRNYVAP--YKPKIMYEGDTSNFDPVPQSQVQ-KMYKQA-TPTE--V----MPQ AqueK011_Aque TDWD-HIRDRPAS--IPVHVKHMADTSNFDDFEELEHQKDH-EES-------------ES LATS2_Mmus IDFSRDIRKQPAP--YVPTISHPMDTSNFDPVDEESPWHEASGESAKAWDTLAS---PSS LATS1_Mmus IDFSSDLRQQSAS--YIPKITHPTDTSNFDPVDPDKLWSDGSEEE-NISDTLNG-WYKNG * :*. * : : *****: . . LATS1_Hsap KHPEHAFYEFTFRRFFDDNGY-PYNYPKPIEYEYINSQGSEQQSDEDDQNTGS------- LATS2_Hsap KHPEHAFYEFTFRRFFDDNGY-PFRCPKPSGAEASQAESSD----LESSDLVD------- T20F10.1_Cele GLHNPAFYEFTYRHFFDTDSV-GCPSLRPSRRRSLRPL----LE--NGTFNES------- wts_Dmel DRTFHGFFEFTFRRFFDDKQP-PDM----------------------------------- LATS_Spur QQTDHAFFEFTFRRFFDDNGH-PY--PMPIDIDSSPGPGEMERSEGDGAAAQS------- AqueK010_Aque DHPEHAFYEFTFIRFAASDRASDAK--KPTIAPSSSSSSSSYHSQAQASSSGSSAHDRPQ AqueK011_Aque DSKDWVFQNFTFKRFEG------------------------------------------- LATS2_Mmus KHPEHAFYEFTFRRFFDDNGY-PFRCPKPSEPAESAD--------PGDADLEG------- LATS1_Mmus KHPEHAFYEFTFRRFFDDNGY-PYNYPKPIEYEYIHSQGSEQQSDEDDQHTSS------- * :**: :* LATS1_Hsap -------------EIKNRDLVYV LATS2_Hsap -------------QTEGCQPVYV T20F10.1_Cele -------------VSEEDSSSHI wts_Dmel --------------TDDQAPVYV LATS_Spur -------------SLDMQDMVYV AqueK010_Aque SSQREHKEMRKEKKRTTPQPVYV AqueK011_Aque --------------LTQRGHVRL LATS2_Mmus -------------AAEGCQPVYV LATS1_Mmus -------------DGNNRDLVYV :