CLUSTAL W (1.83) multiple sequence alignment LKB1_Hsap MEVVDPQ----------------------------------------------------- CG9374_Dmel MTVTTMEAQVKAA--------------HHHHLHHPTGGG--------------------- LKB1_Mmus MDVADPE----------------------------------------------------- par-4_Cele MDAPSTSSGAQSK------------------LLM-------------------------- Lkb1_Ddis MEVEQQPS---------------------------------------------------- LKB1_Spur MLERCLDEDTVS------------------------------------------------ AqueK062_Aque MASRQVARG-QSKKTTSGTGSATSQAITNGHLICPTCSEEIVDPVGKKKGHQSIECNGPC * LKB1_Hsap ------------------------------------------------------------ CG9374_Dmel ------------------------------------------------------------ LKB1_Mmus ------------------------------------------------------------ par-4_Cele ------------------------------------------------------------ Lkb1_Ddis ------------------------------------------------------------ LKB1_Spur ------------------------------------------------------------ AqueK062_Aque HMWLHRQCAGLSRAAFDAAGASNDPFFCPQCVISNQNQEITTLKLKLDEVLNELSALKNE LKB1_Hsap ------------------------------------------------------------ CG9374_Dmel --------AQHKVE---------------------------------------------- LKB1_Mmus ------------------------------------------------------------ par-4_Cele ------------------------------------------------------------ Lkb1_Ddis ------------------------------------------------------------ LKB1_Spur ------------------------------------------------------------ AqueK062_Aque VANLKTEVSQHLVQDDNNPDSIPTDSTMPRTSARPVGNSSRVNMQNRSLPRDRSCNLVIY LKB1_Hsap ------------------------------------------------------------ CG9374_Dmel ------------------------------------------------------------ LKB1_Mmus ------------------------------------------------------------ par-4_Cele ------------------------------------------------------------ Lkb1_Ddis ------------------------------------------------------------ LKB1_Spur ------------------------------------------------------------ AqueK062_Aque GIPECPHECLTSWLRKADRVETPKPRTIDALITALREIGENAVADGINEERQRHLTNLPA LKB1_Hsap ------------------------------------------------------------ CG9374_Dmel ------------------------------------------------------------ LKB1_Mmus ------------------------------------------------------------ par-4_Cele ------------------------------------------------------------ Lkb1_Ddis ------------------------------------------------------------ LKB1_Spur ------------------------------------------------------------ AqueK062_Aque CAYFTLFPANPGVCNLKHKIEKVPELEKIASKLQEKYDFLVFAVRKSLRDHCIDVEDAKA LKB1_Hsap ------------------------------------------------------------ CG9374_Dmel ------------------------------------------------------------ LKB1_Mmus ------------------------------------------------------------ par-4_Cele ------------------------------------------------------------ Lkb1_Ddis ------------------------------------------------------------ LKB1_Spur ------------------------------------------------------------ AqueK062_Aque LIKKSLKKKALAVSYLLPCIDILEKASDFNSFFEFLRRCDFIGYLNYKLLKALSGLIIGG LKB1_Hsap ------------------------------------------------------------ CG9374_Dmel ------------------------------------------------------------ LKB1_Mmus ------------------------------------------------------------ par-4_Cele ------------------------------------------------------------ Lkb1_Ddis ------------------------------------------------------------ LKB1_Spur ------------------------------------------------------------ AqueK062_Aque DEINKLFLEYEKEYAKLLNLDSFQNLIPFFEEKTDESPDAPLGLPCVSFKKPLVRKFSCS LKB1_Hsap ------------------------------------------------------------ CG9374_Dmel ------------------------------------------------------------ LKB1_Mmus ------------------------------------------------------------ par-4_Cele ------------------------------------------------------------ Lkb1_Ddis ------------------------------------------------------------ LKB1_Spur ------------------------------------------------------------ AqueK062_Aque YYAILKQLSGSSVPLRDSTNEKEVTSIEQDALAKWLKEGTVNLTVKRVQMLGPPGSGKTC LKB1_Hsap ------------------------------------------------------------ CG9374_Dmel ------------------------------------------------------------ LKB1_Mmus ------------------------------------------------------------ par-4_Cele -----PGDDEADED---------------------------------------------- Lkb1_Ddis ------------------------------------------------------------ LKB1_Spur ------------------------------------------------------------ AqueK062_Aque SQLLLLNEDPPE-DVTDSTPIACRAVKATRTSIENGHMKRVDAKAFLSRLACDLIESASK LKB1_Hsap ------------------------------------------------------------ CG9374_Dmel --------------------------------------------------------E--- LKB1_Mmus ------------------------------------------------------------ par-4_Cele -----------------------------------------------------HQNR--- Lkb1_Ddis ------------------------------------------------------------ LKB1_Spur --------------------------------------------------------H--- AqueK062_Aque LKETLVPTGGCDGTKSKGESSDNIPTGSPETEATESADTTEKVARLADSANDYHSNKVLQ LKB1_Hsap ------------------------------------------------------------ CG9374_Dmel ------------------------------------------------------------ LKB1_Mmus ------------------------------------------------------------ par-4_Cele ------------------------------------------------------------ Lkb1_Ddis ------------------------------------------------------------ LKB1_Spur ------------------------------------------------------------ AqueK062_Aque DIVEAIPNAEANLNCNWVYIVDSGGQTAFQELLPLFTRAASLNIITIDLSKGVDEKLDLQ LKB1_Hsap ------------------------------------------------------------ CG9374_Dmel ------------------------------------------------------------ LKB1_Mmus ------------------------------------------------------------ par-4_Cele ------------------------------------------------------------ Lkb1_Ddis ------------------------------------------------------------ LKB1_Spur ------------------------------------------------------------ AqueK062_Aque YRIDGASFPCDSNFSYTNIEFLRGVFSSGANLQLYHSPHSEEDAATPEYFVLGTHSDDAK LKB1_Hsap ------------------------------------------------------------ CG9374_Dmel -------------------------------------------EEPDPVEDEMTVLLANK LKB1_Mmus ------------------------------------------------------------ par-4_Cele -------------------------------------------GDPNLQQ--KQKIQLNV Lkb1_Ddis ------------------------------------------------------------ LKB1_Spur -------------------------------------------IPPHWAQTD-------- AqueK062_Aque ATQQKIAIFNKEISSLTSGKKGYSIIPAEQNGDIIYPVNTMLKPGPERQE--ESKNLCDT LKB1_Hsap ------------------------------------------------QLGMFTEGELM- CG9374_Dmel NFHYDVASDLDDDAFVELKEDTA------------------QADDAGAGVGFYNPDELLL LKB1_Mmus ------------------------------------------------PLGLFSEGELM- par-4_Cele DPDY--DDDEDDDCFIDGCEASAP---ITRELVDGAIERRSKDRNVKMSIGVYDEYDDDD Lkb1_Ddis ----------------------------------------------------YTS----- LKB1_Spur ------------------------------------------------HFSFFGDDD--- AqueK062_Aque IFDF--DDDTLDDTFDDTIQLPVRWFAFELTLLEKAGNSSVLHMNDVLSIGRSLEMDDGD LKB1_Hsap ------------------------------------------------------------ CG9374_Dmel DD-------------------------QPHPQ---------------------------- LKB1_Mmus ------------------------------------------------------------ par-4_Cele DDEE----------------E-----TEED------------------------------ Lkb1_Ddis ------------------------------------------------------------ LKB1_Spur ------------------------------------------------------------ AqueK062_Aque TKKALEYLHNVTIILYYPQVLPDIVFVDPHPILDILSRLLALTYKIKRKFLRRLTRETPS LKB1_Hsap ------------------------------------------------------------ CG9374_Dmel ---------VTWLDDDEIE-TLDR------------------------------------ LKB1_Mmus ------------------------------------------------------------ par-4_Cele --------QRRRFVEGIR------------------------------------------ Lkb1_Ddis ------------------------------------------------------------ LKB1_Spur ------------------------------------------------------------ AqueK062_Aque EPELDKLSKEGIFTESLLDKLKDDQRFSKSDFINLLLHLHIIVETQDGYFIPFALPPFAL LKB1_Hsap ------------------------------------------------------------ CG9374_Dmel ------------------------------------------------------------ LKB1_Mmus ------------------------------------------------------------ par-4_Cele ------------------------------------------------------------ Lkb1_Ddis ------------------------------------------------------------ LKB1_Spur ------------------------------------------------------------ AqueK062_Aque PPFGSTGSLPKSDIINPLLIVWLNPVTKEVLPVPRGIFPLAVVNLMKLNQPLFQFFPGSQ LKB1_Hsap -----------------------------------------------S------------ CG9374_Dmel ----------------------------------------------VT------------ LKB1_Mmus -----------------------------------------------S------------ par-4_Cele -NIRHKQQES-------------------------FDLEEH-PIPVES------------ Lkb1_Ddis ------------------------------------------------------------ LKB1_Spur ------------------------------------------------------------ AqueK062_Aque EYLRYRDAMSFRVRVHDEFIGTIHFIKKHRHIEIHFDTNELKYCPLICEAVTEAIRSSNV LKB1_Hsap ------------------------------------------------------------ CG9374_Dmel ------------------------------------------------------------ LKB1_Mmus ------------------------------------------------------------ par-4_Cele ------------------------------------------------------------ Lkb1_Ddis ------------------------------------------------------------ LKB1_Spur ------------------------------------------------------------ AqueK062_Aque VINLKPLHKLAFACCDMKDCYCIVTNEAEEKVECTLCPRPALISGRKEYWNWFHVTHKSL LKB1_Hsap ------------------------------------------------------------ CG9374_Dmel ------------------------------------------------------------ LKB1_Mmus ------------------------------------------------------------ par-4_Cele ------------------------------------------------------------ Lkb1_Ddis ------------------------------------------------------------ LKB1_Spur ------------------------------------------------------------ AqueK062_Aque TEAPKLARETTPKTLDITDLKDVLTLLRECHFNGDWEGLGIELGLYKHPTLSDIQQSYTR LKB1_Hsap ------------------------------------------------------------ CG9374_Dmel ------------------------------------------------------------ LKB1_Mmus ------------------------------------------------------------ par-4_Cele ------------------------------------------------------------ Lkb1_Ddis ------------------------------------------------------------ LKB1_Spur ------------------------------------------------------------ AqueK062_Aque SSTLTECLASWLLRVDGVDQNGGATYVSLANAFETLGQNAIADHIRINDAHHILDITCLR LKB1_Hsap ------------------------------------------------------------ CG9374_Dmel ------------------------------------------------------------ LKB1_Mmus ------------------------------------------------------------ par-4_Cele ------------------------------------------------------------ Lkb1_Ddis ------------------------------------------------------------ LKB1_Spur ------------------------------------------------------------ AqueK062_Aque DVHLSLCDLYESKWLDLGDQLGLYAKTLQAIEDDYSDDRRCLRETLVKWLAGADDVLPSW LKB1_Hsap ------------------------------------------------------------ CG9374_Dmel ------------------------------------------------------------ LKB1_Mmus ------------------------------------------------------------ par-4_Cele ------------------------------------------------------------ Lkb1_Ddis ------------------------------------------------------------ LKB1_Spur ------------------------------------------------------------ AqueK062_Aque GSLVQALEAIGENNVAENIIKNGSSSKKLPVCTSLMATAMMNTPPHPPSGGGRGGSGRGH LKB1_Hsap ------------------------------------------------------------ CG9374_Dmel ------------------------------------------------------------ LKB1_Mmus ------------------------------------------------------------ par-4_Cele ------------------------------------------------------------ Lkb1_Ddis ------------------------------------------------------------ LKB1_Spur ------------------------------------------------------------ AqueK062_Aque GITIDVSPPSPHDYIHSSPQPHSSRDRDYTSGMSPGSGDLPSPFFNHPQLIESPIPEEPG LKB1_Hsap ---VG-MDTFIHRID------------STEVIYQP--RRKRAKLIGKYLMGDLLGEGSYG CG9374_Dmel ---LDMGNMFFNRVD------------SQDIIYQQ--KKKSIKMVGKYIMGDVLGEGSYG LKB1_Mmus ---VG-MDTFIHRID------------STEVIYQP--RRKRAKLIGKYLMGDLLGEGSYG par-4_Cele ---EA-MRQFINQQVNNAMMFNQDNSEFQHIEFEPIVKQKGPKIIEGYMWGGQIGTGSYG Lkb1_Ddis ----N-FIIHLNENE------------DNGISYRS--RKSTPKLVKHYILGEVLGEGAYG LKB1_Spur ----D-DHIFIHRVD------------SADIVYQP--RKKRAKMVGKYLMGDTLGEGSYG AqueK062_Aque EDHFGDDFTDFPRYD------------SRDIVYEE--PQRQAK------IGDLLGVGAYS : . : :. : * * :* *:*. LKB1_Hsap KVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEE CG9374_Dmel KVKEAMNSENLCRLAVKILTKRKLRRIPNGEQNVTREIALLKQLKHRHVVELVDVLYNEE LKB1_Mmus KVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHRNVIQLVDVLYNEE par-4_Cele KVKECIDMYTLTRRAVKIMKYDKLRKITNGWENIRSEMSILRRMNHRNVIKLIEIFNIPA Lkb1_Ddis KVKDGMDSFTQKRVAVKILKRARLKKIPGGEASVLKEINITKKLHNKHIIKLIDHFIIEE LKB1_Spur KVKEALDSESLCRRAVKILKKKKLKRIPCGEQNVKREIQLLKRLNHPNIIQLVEVLQNDE AqueK062_Aque KVREMLDCVTLCRRAVKIMKQRRLSRILNGEENVRREIKILKKLNHRNVIKLLDVFSDDN **:: :: . * ****:. :* :* * .: *: : :::.: ::::*:: : LKB1_Hsap KQKMYMVMEYCVCGM-QEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPG CG9374_Dmel KQKMYLVMEYCVGGL-QEMIDYQPDKRMPLFQAHGYFKQLVDGLEYLHSCRVIHKDIKPG LKB1_Mmus KQKMYMVMEYCVCGM-QEMLDSVPEKRFPVCQAHGYFRQLIDGLEYLHSQGIVHKDIKPG par-4_Cele KGKVYMVFEYCIGSV-QQLLDMEPARRLTIGESHAIFIELCQGLNYLHSKRVSHKDIKPG Lkb1_Ddis KGKLYIVYEYVGGGTSQNILENAPNGRLPPHQSQFIFRQLIEACEYIHSQKILHRDIKPD LKB1_Spur KQKMYLFMEYCVSGL-QDMLDAAECKKFPIWQANDYFCQLVDGLEYLHSQHVVHKDIKPS AqueK062_Aque KQKLYIVLEYCVGGL-QEMLDKAPRNKFPIWQAHKYFVQLIEGLEYLHSCGIVHKDIKPG * *:*:. ** . *:::: ::. ::: * :* :. :*:** : *:****. LKB1_Hsap NLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANG-LDTFSGFKVDIW CG9374_Dmel NLLLSLDQTLKISDFGVAEQLDLFAPDDTCTTGQGSPAFQPPEIANG-HETFAGFKVDIW LKB1_Mmus NLLLTTNGTLKISDLGVAEALHPFAVDDTCRTSQGSPAFQPPEIANG-LDTFSGFKVDIW par-4_Cele NLLVSIDFTVKICDFGVAEQINLFQRDGRCTKVNGTPKFQPPECIYGNHDFFDGYKADMW Lkb1_Ddis NILFTHANVLKLSDFGVAEDSSQLEDFECLSRSYGSPAFQPPELTQF-QTTFSPFKIDIW LKB1_Spur NLLLTTAGILKISDFGVAELLDHFTEDDACRTSQGSPAFQPPEIANG-QDVFSGFKVDIW AqueK062_Aque NLLLTTDDVVKISDFGVAEELDRFSQSDRCCNFQGSPAFQSPEIASG-QDNWSGFKADIW *:*.: :*:.*:**** : *:* **.** : :* *:* LKB1_Hsap SAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPG---DCGPPLSDLLKGMLEYEPAK CG9374_Dmel SSGVTLYNLATGQYPFEGDNIYRLLENIGRGQWEAPAWLYEMDADFANLILGMLQADPSK LKB1_Mmus SAGVTLYNITTGLYPFEGDNIYKLFENIGRGDFTIPC---DCGPPLSDLLRGMLEYEPAK par-4_Cele SAGVTLYNLVSGKYPFEKPVLLKLYECIGTEPLQMPTNV-QLTKDLQDLLTKLLEKDFNE Lkb1_Ddis AMGVTLYLMTIGKFPFSGANMFVLFENISKCKIEFPN---DLDKDLVNLIKGILQVDHIQ LKB1_Spur SSGITLYNIVTGKFPFEGDNIYRLFENIGKGDYTIPA---DVPPQLTNLLEGMLSIDPDT AqueK062_Aque ASGVTLYHFTTGKFPFEGESVYKLFAVISQCTYTLPPE---LPPVLQDLIRGMLLKDPDK : *:*** :. * :**. : * *. * : :*: :* : LKB1_Hsap RFSIRQIRQHSWFRKKH--PPAEAPVPIPPS----------------------------- CG9374_Dmel RLSLQEIRHDTWFRSAP--VKTGPPIPIPP------------------------------ LKB1_Mmus RFSIRQIRQHSWFRKKH--PLAEALVPIPPS----------------------------- par-4_Cele RPTCLETMIHPWFLSTF--PEDQGLGRIMER----------------------------- Lkb1_Ddis RFSLGQIKNHPWCIKYI--PEVEPFVPLLEESKFLPLEMAYGDDEGDDGGGGRGGGGDDE LKB1_Spur RLNVHQIKEHVWVRKKH--DLVGEPVHLPLL----------------------------- AqueK062_Aque RLDIEQIRRHTWFISKHSKPLKEELVRFPPY----------------------------- * : . * . : LKB1_Hsap ----------------------PDTKDRWRSMTVVP------------------------ CG9374_Dmel -----------------------LKGDKYRNSTVIP------------------------ LKB1_Mmus ----------------------PDTKDRWRSMTVVP------------------------ par-4_Cele ----------------------MRTGDR--PLTMLS------------------------ Lkb1_Ddis LIFGYENDGNTIDLQDPEYIPSISVGDQPPSTPILHSSDHHHHHHHNNQHQHQQQQQQLQ LKB1_Spur ----------------------PDSCDEVRSMTVVP------------------------ AqueK062_Aque ----------------------QDSKDRYRGSTVIP------------------------ *. .:: LKB1_Hsap YLEDLHGAD--------------EDEDLFDIEDDIIYTQDFTV----------------- CG9374_Dmel YLEAYHYGT--------------QEEDVYFTEHDVN--QELA------------------ LKB1_Mmus YLEDLHGRA-----------EEEEEEDLFDIEDGIIYTQDFTV----------------- par-4_Cele SMTALYDGI-------------TP-EDELIIEDNLGIIQQI-L----------------- Lkb1_Ddis QSQQFHGNG--------------DNNLLFDSNNNLIFDSNNNLLFNTNNNEHLINGLPVH LKB1_Spur YIEDMFNPC-----------PSE--DGSYSDE----YYEDR------------------- AqueK062_Aque YLESFYNYEGVAGLEATGRWDSQDEEALFDTQESS-TG---------------------- . : : LKB1_Hsap -----PGQV------------------------------------------------PEE CG9374_Dmel ------RQA------------------------------------------------AAA LKB1_Mmus -----PGQV------------------------------------------------LEE par-4_Cele -----PINLTSEAV--------LERGSFPGFKFLE----AKPGDGPDG---VEG---SED Lkb1_Ddis PIELDPVNIKKSSIGTNISDVALIRENYI-----CSDNDASS--GQDDEDYSDDNEISGE LKB1_Spur ----------------------------------------------------------EQ AqueK062_Aque ---------------------------------------------------IPS---ATQ LKB1_Hsap EAS--------------HNG--QRRGLPKAV-----CMN----GTEAA-------QLSTK CG9374_Dmel ASE--------------IRA--KQSAAALAA-----CHTYEPPSTSAAAASNSLGNGSRE LKB1_Mmus EVG--------------QNG--QSHSLPKAV-----CVN----GTE-P-------QLSSK par-4_Cele SAA----------PLGPQRR-PSSRSMPTCAPPGPAAGNAQNSTAENGAETDGVASA-SD Lkb1_Ddis DLNPTNHHHHRADRVGSRDK-SSRSSKRKNS----SSNNNNNNSTSPKVEFN--PNRSSP LKB1_Spur YSA---------------QA---SQDAPQIV-------------VE-P-------DESSD AqueK062_Aque SLA----------SVSHERSLDTIASRK------SRVHSQENVLFPTSKSVDELGVTAIG LKB1_Hsap SRAEGR--APNPARKAC-SASSKIRRL-SACKQQ CG9374_Dmel EAPVKKKGSALKRRAKKLTSCISVRKL-SHCRTS LKB1_Mmus VKPEGRPGTANPARKV--CSSNKIRRL-SACKQQ par-4_Cele PPPTAAPGAP-PRRRK--RNFFSCIF-RSRTDSA Lkb1_Ddis QPPLRNS--S-NRRPK--ITFESPHNK-SKCIIN LKB1_Spur PSPEA----EEPQKEK--K-ISRVRKLSSTCKQQ AqueK062_Aque PIPS--PKPP-K--KR--RG-SKRRI-SEQCTHQ . .