CLUSTAL W (1.83) multiple sequence alignment M04C9.5_Cele MTPRIRRKTNI--------A--SFRIFHISGDYILCIVMSIYFLL--S-----SK-TDNI DDB0229430_Ddis M----------------------------------------------------------- MAK_Hsap -----------------------------------------------------------M ICK_Hsap -----------------------------------------------------------M CG4588_Dmel -----------------------------------------------------------M ICK_Mmus -----------------------------------------------------------M MAK_Mmus -----------------------------------------------------------M IME2_Scer MVEKRSRQSSS--------SGSEFSVP---PDV------DNPP-L--S-----IPLKTLS MAK_Spur M----------------------------------------------------------- CC1G_11298_Ccin MYNNTNANPTRNRQPPLRETITVVGIPSVSIDN------DRLVVG--S-----SQ-TSST AqueK132_Aque MSV--------------------------------------------------------L MAK_d_Smoe MHKTSI--------------------------------MQRYVLL-CFSGAN-SD-FVVL MAK_c_Smoe MHKTSI--------------------------------MQRYVLLLCFTGAN-SD-FVVL MAK_e_Smoe MQRYITKLSH--------------------------------------SQSFFLP-FFSF MAK_b_Smoe M----------------------------------------------------------- MAK_a_Smoe MQRYITKLSH--------------------------------------SQSFFLP-FFSF GK041_Glam M----------------------------------------------------------- GK039_Glam M----------------------------------------------------------- M04C9.5_Cele FRYLM--TKRLGDGTFGEVMLAKK------------------------------------ DDB0229430_Ddis EKYQF--IKQVGDGAYGDVIKAID------------------------------------ MAK_Hsap NRYTT--MRQLGDGTYGSVLMGKS------------------------------------ ICK_Hsap NRYTT--IRQLGDGTYGSVLLGRS------------------------------------ CG4588_Dmel NRYIT--LTQLGDGTYGTVVLGQR------------------------------------ ICK_Mmus NRYTT--IKQLGDGTYGSVLLGRS------------------------------------ MAK_Mmus NRYTT--MKQLGDGTYGSVLMGKS------------------------------------ IME2_Scer DRYQL--IEKLGAGSFGCVTLAKAQFPLSN---------ILGKQHDIRGTLMDQPKNGHQ MAK_Spur NQYQV--TKQLGDGTYGSVILGCR------------------------------------ CC1G_11298_Ccin RSYTP--IKVLGDGSFGTVWLCDWHTTLPPNTPLSPMQCGQG-----------------A AqueK132_Aque QKYTF--LKVLGDGTFGVVSLAKE------------------------------------ MAK_d_Smoe SRYKV--IKQLGDGTYGTVWKAVN------------------------------------ MAK_c_Smoe SRYKV--IKQLGDGTYGTVWKAVN------------------------------------ MAK_e_Smoe KRYQV--IKQVGDGTYGSVWKAID------------------------------------ MAK_b_Smoe TRYSIDYSTRLGRGTGGTVREGIN------------------------------------ MAK_a_Smoe KRYQV--IKQVGDGTYGSVWKAID------------------------------------ GK041_Glam ENYTV--ITELGSGNYGTVYKAREN----------------------------------- GK039_Glam DAYTP--VRRVGSGTYGDVLHAVD------------------------------------ * :* * * * M04C9.5_Cele ---IDTGDRVAIKRMKKKFY-SWEEAMSLREVK-------------------SLKKL-NH DDB0229430_Ddis ---VKTGEIVAIKRMKKKFS-DWKECIQLREIK-------------------ALKKL-KH MAK_Hsap ---NESGELVAIKRMKRKFY-SWDECMNLREVK-------------------SLKKL-NH ICK_Hsap ---IESGELIAIKKMKRKFY-SWEECMNLREVK-------------------SLKKL-NH CG4588_Dmel ---KDTGEKVAIKRMKRKYY-SWEEAMNLREVK-------------------SLKKL-SH ICK_Mmus ---IESGELIAIKKMKRKFY-SWEECMNLREVK-------------------SLKKL-NH MAK_Mmus ---NESGELVAIKRMKRKFY-SWDECMNLREVK-------------------SLKKL-NH IME2_Scer NYITKTQGVVAIKTMMTKLH-TLQDYTRVREIK-------------------FILAIPAN MAK_Spur ---FDNGEKVAIKKMKKKFY-SWNECMELREVK-------------------SLKKL-NH CC1G_11298_Ccin RPEWAGKRLVAVKRMKKRWEGGWDECQKLKELE-------------------SLRAIPFH AqueK132_Aque ---KETGNMVAIKKMKQDFL-SWEECLKLKEVQVSELFVSPYIYKYGRNDVHALQRL-KH MAK_d_Smoe ---KVTNETVAIKKMKRKYL-SWDECMNLREVK-------------------SLRKL-NH MAK_c_Smoe ---KVTNETVAIKKMKRKYL-SWDECMNLREVK-------------------SLRKL-NH MAK_e_Smoe ---RCTNEFVAIKKMKTKFH-GWEECMNLREVK-------------------CLQRL-DH MAK_b_Smoe ---LDTMEKVAIKEMVEHLN-LHEETKLVY--G-------------------LLQEC-QH MAK_a_Smoe ---RCTNEFVAIKKMKTKFH-GWEECMNLREVK-------------------CLQRL-DH GK041_Glam ----KKGTLVAIKHMKQKYK-SWSECVTLKEVK-------------------SLIRMKEH GK039_Glam ----TKGDFVAIKIMNSHTL-CVSDPLQLPEVA-------------------TLRRLPPH :*:* * .: : : : M04C9.5_Cele PNIIKLREVIR--ENDILYFVFEFM----------------QE-NLYELMK-DRD----R DDB0229430_Ddis PNIVKLLEIIL--ERDELFFVFEYL----------------EN-NLYESIK-DRT----K MAK_Hsap ANVIKLKEVIR--ENDHLYFIFEYM----------------KE-NLYQLMK-DRN----K ICK_Hsap ANVVKLKEVIR--ENDHLYFIFEYM----------------KE-NLYQLIK-ERN----K CG4588_Dmel PNIVKLKEVIR--ENDTLYFVFEYM----------------KE-NLYQMIK-DRD----T ICK_Mmus ANIVKLKEVIR--ENDHLYFIFEYM----------------KE-NLYQLIK-ERN----K MAK_Mmus ANVIKLKEVIR--ENDHLYFVFEYM----------------KE-NLYQLMK-DRN----K IME2_Scer DHLIQIFEVFIDSENYQLHIVMECM----------------EQ-NLYQMMK-HRRR---R MAK_Spur ANIVKLKEVIR--EDNILYFVFEYM----------------TE-NLYELMK-GRD----R CC1G_11298_Ccin PNIIPLYDFFLLPTSKELYFVFESM----------------E-GNLYHLIK-ARKG---R AqueK132_Aque VNIIKATEIFR--DNNTLYFVFEYM----------------RQ-NLYELIK-SRGS---N MAK_d_Smoe PNIVKLKEVIR--ENNELFFVFEYMVLYFCFPFSATHFYLQEC-NLYQMMK-DRQ----K MAK_c_Smoe PNIVKLKEVIR--ENNELFFVFEYMVLYFCFPFSATHVYLQEC-NLYQMMK-DRQ----K MAK_e_Smoe PNIVQLKEVIW--EHGELFLVFEYM----------------EC-NLYQVMK-DRS----K MAK_b_Smoe ENIVKLLDVGS--IGGKTYMVFEHM----------------FG-DLYKFKK-RLGMLMKR MAK_a_Smoe PNIVQLKEVIW--EHGELFLVFEYM----------------EC-NLYQVMK-DRS----K GK041_Glam PNIVKLMEVV--RQKEDLYFVFEYI----------------NSGNLFDFVVQQRSAG--I GK039_Glam PNIIRLIRVVV--TRDHTHLIFEYA----------------GGGTLLNFLR-S-SG---- ::: . .:::* * . M04C9.5_Cele YFPESVIRNIIYQVLQGLAFMHKNGFFHRDMKPENIMCNG-------------------- DDB0229430_Ddis LLPETTIRNIIYQILQALHFMHTNGFFHRDLKPENIMLVG-------------------- MAK_Hsap LFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMG-------------------- ICK_Hsap LFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMG-------------------- CG4588_Dmel HLPEPELKSILFQVLTGLAFMHRHGFFHRDLKPENLLCSG-------------------- ICK_Mmus LFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMG-------------------- MAK_Mmus LFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMG-------------------- IME2_Scer VFSIPSLKSILSQILAGLKHIHEHNFFHRDLKPENILITPSTQYFEKEYMNQIG------ MAK_Spur LLPEPVIRNIVYQILQGMAYIHKNGFFHRDMKPENLLCCG-------------------- CC1G_11298_Ccin PLAGGLVSSIFQQITLGLDHIHTHGYFHRDMKPENVLVTTVGLF-DYTPVSPIAPPNAPK AqueK132_Aque LFPEHVVRNISYQIIQAVSYMHSQGLFHRDLKPENILCQG-------------------- MAK_d_Smoe LFPEAKIRNWCFQVLQGLAYMHREGYFHRDLKPENLLVT--------------------- MAK_c_Smoe LFPEAKIRNWCFQVLQGLAYMHREGYFHRDLKPENLLVT--------------------- MAK_e_Smoe MLSEERIRIWSFQVLRALDYMHQHGIFHRDLKPENLLVSD-------------------- MAK_b_Smoe TLNREEIKTIIEQILQALAYMHEHGIVHQDIKTANVLINKE------------------- MAK_a_Smoe MLSEERIRIWSFQVLRALDYMHQHGIFHRDLKP--------------------------- GK041_Glam KISELVAKDLVRQILEGLEHIHRNNYMHRDLKCENILVSDDGT----------------- GK039_Glam PLKEHMLRNIAFRILQGLYHIHTNSVIHRDLKLENILLTSETGD---------------- : :: .: .:* .. .*:*:* M04C9.5_Cele -----TELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEILLRST-SYNSPIDMWALGCI DDB0229430_Ddis ------ERLKIADFGLAREIESKPPFTDYISTRWYRAPEVLLRCT-YYNAPIDIWAVGAI MAK_Hsap -----PELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSS-VYSSPIDVWAVGSI ICK_Hsap -----PELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLLRST-NYSSPIDVWAVGCI CG4588_Dmel -----PDLIKIADFGLAREIRSRPPFTDYVSTRWYRAPEVLLHST-NYGSTIDLWAMGCI ICK_Mmus -----PELVKIADFGLAREIRSRPPYTDYVSTRWYRAPEVLLRST-NYSSPIDIWAVGCI MAK_Mmus -----PELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSS-VYSSPIDVWAVGSI IME2_Scer -YQ-DNYVIKLADFGLARHVENKNPYTAYVSTRWYRSPEILLRSG-YYSKPLDIWAFGCV MAK_Spur -----PELIKIADFGLARETRSRPPYTDYVSTRWYRAPEVLLRST-KYSSPIDMWAVGCI CC1G_11298_Ccin ERD-VVTIIKLADFGLARETRSRPPYTEYVSTRWYRAPEVLLLSR-EYSNPVDLWALGTI AqueK132_Aque -----HELIKLADFGQAREIRSRPPYTDYVSTRWYRAPEVQLGSK-NYNSPIDIWAVACI MAK_d_Smoe -----VDVIKIADFGLAREVRSRPPYTNYVSTRWYRAPEVLLQSS-LYNSAVDMWAMGAI MAK_c_Smoe -----VDVIKIADFGLAREVRSRPPYTNYVSTRWYRAPEVLLQSS-LYNSAVDMWAMGAI MAK_e_Smoe ------EAIKVADFGLAREVYSVAPYTDYVATRWYRAPEVLLQAP-SYSYAIDIWAMGAI MAK_b_Smoe -----GTKVKLCDFDHARRVTTPPRDPETIGTLAYNAPEIILGDTQELGSGVDVWGAGVI MAK_a_Smoe ----------------------------------------------------DIWAMGAI GK041_Glam ----GTRCVKIADLGCAKSLLERPPHTVYVGTRWYRAVELFLKDS-SYSAKNDIWACACI GK039_Glam -ANGDIVGVKIADFGLSRAQGSRQ-NTDYVSTRWYRAPELLLHYS-GYGPPIDIWAAGCC *:*. . M04C9.5_Cele MAELYILRPLFPGTSE---MDQLFKIISILGTPNKD-----------------EWPEGYQ DDB0229430_Ddis MAELYSLKPMFPGSSE---IDQLFKICTIMGSPTSA-----------------TWIDGIK MAK_Hsap MAELYMLRPLFPGTSE---VDEIFKICQVLGTPKKS-----------------DWPEGYQ ICK_Hsap MAEVYTLRPLFPGASE---IDTIFKICQVLGTPKKT-----------------DWPEGYQ CG4588_Dmel MAELYTFRPLFPGSSE---VDQLFKICSVLGTPDKD-----------------DWPDGYR ICK_Mmus MAEVYTLRPLFPGASE---IDTIFKICQVLGTPKKT-----------------DWPEGYQ MAK_Mmus MAELYTFRPLFPGTSE---VDEIFKICQVLGTPKKS-----------------DWPEGYQ IME2_Scer AVEVTVFRALFPGANE---IDQIWKILEVLGTPIKRS-DFVNTNHITAPPPGGFWDDASN MAK_Spur MAELYTLRPLFPGSSE---VDEIFKITTVLGTPKKE-----------------EWVEGFR CC1G_11298_Ccin MAELVNLRPLFPGSDQ---VDQVARVCEVLGDPAEDYRD--NGGNV---VGGGQWPHGVS AqueK132_Aque MSEVYSGRPLFPGSGT---IDQVYKICGVLGTPTKA-----------------TWGEGVG MAK_d_Smoe MAELFNLRPIFPGASE---ADEIYKICSVLGNPSQA-----------------TWPDGMK MAK_c_Smoe MAELFNLRPIFPGASE---ADEIYKICSVLGNPSQA-----------------TWPDGMK MAK_e_Smoe MAELFNLQPLFPGASE---ADEIYKICSVLGSPNYH-----------------TWPDGMQ MAK_b_Smoe LAELVLGYNPFSVVRESHAARELYRVVEEIKER--------------------------- MAK_a_Smoe MAELFNLQPLFPGASE---ADEIYKICSVLGSPNYH-----------------TWPDGMQ GK041_Glam LCEILLMKPLFPGAND---IDMLNLITSTLGSPTRE-----------------DWPAGYA GK039_Glam FAELLTGDPLFPGDTE---IQQLQLICAFLK-PLKPD-----------------ACKGAM *: *. : : : M04C9.5_Cele LASAMNFRFQQVVAT---PMEQ----VVN-----------TI-SKEGMKLMMDMMLWNPE DDB0229430_Ddis LANSMGFTFPNVQPPSINPLST----LLP-----------NA-NQDAIELITDLLQYDPL MAK_Hsap LASSMNFRFPQCVPI---NLKT----LIP-----------NA-SNEAIQLMTEMLNWDPK ICK_Hsap LSSAMNFRWPQCVPN---NLKT----LIP-----------NA-SSEAVQLLRDMLQWDPK CG4588_Dmel LASMIHFRYPDCIKV---PLSS----VVS-----------RC-SQNGLDLLEDMLAYDPD ICK_Mmus LSSAMNFLWPQCIPN---NLKT----LIP-----------NA-SSEAIQLLRDLLQWDPK MAK_Mmus LASSMNFRFPQCIPI---NLKT----LIP-----------NA-SSEAIQLMTEMLNWDPK IME2_Scer LVHKLNLKLPYVEGS---SLDH----LLS-----------SSQLSDLSEVVKKCLRWDPN MAK_Spur LASQMNFKFPQCVAM---PLKT----IIP-----------NA-SPESIHLIRDMLLWDPQ CC1G_11298_Ccin LARDVGFQFPRIEPK---DIFS----LFD-----------ASVPRSLIQCIRDLLRWDPA AqueK132_Aque LAVSMSIRLPIMVPT---PLSA----LVP-----------TA-SDDGISVMKEMLQWNPR MAK_d_Smoe LAKCMNFRFPQ-----------------------------------------AMFAWDPL MAK_c_Smoe LAKCMNFRFPQFVPA---NLSA----LVP-----------SA-SAEAIDLMKAMFAWDPL MAK_e_Smoe LAVRKGFRFPQFAPA---GLQS----LIP-----------SA-SPAAVDMISAMLCWDPN MAK_b_Smoe --------------------------LHR-----------EIGDEDILELLDNMLVWEPE MAK_a_Smoe LAVRKGFRFPQFAPA---GLQS----LIP-----------SA-SPAAVDMISAMLCWDPN GK041_Glam LAERIGYKFPRATQSRQEKLRY----LFP-----------NV-TEDCINLLSRMFEFDQN GK039_Glam HA------LPRFITE---NMTVSDADIYTLAEAREALRRELGCSHVLADLLAHMLAWNPE : :: M04C9.5_Cele KRPNANQSLRYKYFQV-AEKLGAPVVSQP-APG--SIRKTS------------------- DDB0229430_Ddis KRPTPLQALQHRYFKV-SIPSSI-LL---------------------------------- MAK_Hsap KRPTASQALKHPYFQV-GQVLGPSSNHLE-SKQ--SLNK--------------------- ICK_Hsap KRPTASQALRYPYFQV-GHPLGSTTQNLQ-DSE--KPQKGI-L-EK-------------- CG4588_Dmel KRPTAQQSLKYPYFHA-LKRISPTAATKA-N-V--RLNSKYAA-SN------GHPVQSVS ICK_Mmus KRPTASQALRYPYFQI-GHPLGIISKDSG------KPQREV-Q-DK-------------- MAK_Mmus KRPTASQALKHPYFQV-GQVLGSSAHHLD-TKQ--TLHK--------------------- IME2_Scer ERATAQELCEMPFFEN-TVASQVDARGNV------TNTEQA-LIFA-------------- MAK_Spur KRPTAAQCLKYKYFQV-GQNLGAKAQP-P-AQQ--HQQNQM-A-QR-------------- CC1G_11298_Ccin KRLTSKQCLDHLYLRE-TIHRNNIPMPSGLRAASVSQTSIP-MMSSHLNGSSSHPSLSSH AqueK132_Aque RRPTAKQVLMHKYFQV-GHPYHTPSQVTS-TTG--HSTKNT-L-TN-------------- MAK_d_Smoe KRPTPSQALQHPFFQV-CSLSMFCTEA--------------------------------- MAK_c_Smoe KRPTPSQALQHPFFQV-CSLSMFCTEA--------------------------------- MAK_e_Smoe RRPTAYQLRQHPFFYQFGLCIPPPIE---------------------------------- MAK_b_Smoe ERWSAERALSSSFFED-GTRQMCGDPYQQ------------------------------- MAK_a_Smoe RRPTAYQLRQHPFFYQFGLCIPPPIE---------------------------------- GK041_Glam KRLSAQDCLRHPWFVN-TCPTTAAASASS------------------------------- GK039_Glam DRITAQRALMHQFFA--------------------------------------------- * .. :: M04C9.5_Cele ------------------------------------------------------------ DDB0229430_Ddis -------------------------------------------------KPNFIE----- MAK_Hsap ---QLQPLE---------------------------------------SKPSLVE----- ICK_Hsap ---AGPPPY---------------------------------------IKPV-------- CG4588_Dmel N--NVLPVQEKLQAVTELLHQTNNNMNSHSNLGKNNNLAPKNGGVPRKYQPKLSFLTTSE ICK_Mmus ---TGPPPY---------------------------------------IKPA-------- MAK_Mmus ---QLQPLE---------------------------------------PKPSSSE----- IME2_Scer ---GINPV---------------------------------------------------- MAK_Spur ---QAPNQN---------------------------------------SAKRRVL----- CC1G_11298_Ccin TPRNVPPSH---------------------------------------SNSA-HH----- AqueK132_Aque ---T--PNR---------------------------------------EKER-------- MAK_d_Smoe ------------------------------------------------IK---------- MAK_c_Smoe ------------------------------------------------IK---------- MAK_e_Smoe -------------------------------------------------RPYVIT----- MAK_b_Smoe ------------------------------------------------------------ MAK_a_Smoe -------------------------------------------------RPYVIT----- GK041_Glam ------------------------------------------------------------ GK039_Glam ------------------------------------------------------------ M04C9.5_Cele ----------------------AASV---------------KS----DTKAMTA------ DDB0229430_Ddis -----------------LSNKYLIKN---------------GYINNNINNNSN-YSNNNN MAK_Hsap -----------------VEPKPLPDI---------------IDQVVGQPQPKT-S----- ICK_Hsap ------------------PPAQPPAK---------------PHTRISSRQHQA-S----- CG4588_Dmel MGAGSHADSSSLVGGATVDGVPVPQHQNGGESINDIYLNRNISQLFGLPAGP-QH----- ICK_Mmus ------------------PPAQAPAK---------------AYTLISSRPSQA-S----- MAK_Mmus -----------------RDPKPLPNI---------------LDQPAGQPQPKQ-G----- IME2_Scer -----------------------A-----------------------------TN----- MAK_Spur -----------------AESKPAPSP---------------LS----KVQPKRDN----- CC1G_11298_Ccin -----------------VRPPPVPSH---------------FPE---VPPP--QN----- AqueK132_Aque ------------------ENERGSRW---------------QE----DKEGKR-A----- MAK_d_Smoe ------------------------------------------------------------ MAK_c_Smoe ------------------------------------------------------------ MAK_e_Smoe -----------------IDPDEQADY---------------NYYRRGQIHNTG-Y----- MAK_b_Smoe ------------------------------------------------------------ MAK_a_Smoe -----------------IDPDEQADY---------------NYYRRGQIHNTG-Y----- GK041_Glam ------------------------------------------------------------ GK039_Glam ------------------------------------------------------------ M04C9.5_Cele KAAK------------------------K------------D--------Y-------IG DDB0229430_Ddis NNNL------------------------NSNS---------E--------N---LNNVNK MAK_Hsap QQPL------------------------QPI---------QP--------P---QN-LSV ICK_Hsap QPPL------------------------HLT---------YP--------Y---KAEVSR CG4588_Dmel QQQQ------------------------QVH---------HP--------NVSFSTTSSR ICK_Mmus QPPQ------------------------HSV---------HP--------Y---KGDVSR MAK_Mmus HQPL------------------------QTI---------QP--------P---QN-TVT IME2_Scer TKPI----------------------YFNSSTK-------LPAET---ESN---DIDISN MAK_Spur AQPK------------------------DSM---------DD--------F---FANLGK CC1G_11298_Ccin SQPTPLPSVPHQPIPLHAQNGRRPHPIVGWTGPSPQPASDYPMDTSPSEPY---ANGHAN AqueK132_Aque NQYL------------------------GGA---------GP--------Y---DRNVSG MAK_d_Smoe -----------------------------------------P------------------ MAK_c_Smoe -----------------------------------------P------------------ MAK_e_Smoe ------------------------------------------------------------ MAK_b_Smoe ------------------------------------------------------------ MAK_a_Smoe ------------------------------------------------------------ GK041_Glam -------------------------SFVGTTGVGGDDA---------------------- GK039_Glam ------------------------------------------------------------ M04C9.5_Cele ------------------------------SENV-----SPQQPA---K--V-IDRHIN- DDB0229430_Ddis NN----------------------------QQ--------PHSPQ---KIQT-PKPKNS- MAK_Hsap QQP---------------------------PKQQ-----SQEKPP---Q--T-LFPSIVK ICK_Hsap TDH---------------------------PSHL-----QEDKPS---P--L-LFPSLHN CG4588_Dmel NAGAIYVNGSHLSYDTANMNAKNNAKFVVGASNG-----GYYVPVA-RP--SLLGPDAKV ICK_Mmus TEQ---------------------------LSHV-----QEGKPS---P--P-FFPSLHN MAK_Mmus HPP---------------------------PKQQ-----GHQKPP---Q--T-MFPSIIK IME2_Scer NDH---------------------------DSHAMCSPTLNQ----EKL--T-L------ MAK_Spur ------------------------------SKDV-----EPSKPV---Q--E-KAPNAG- CC1G_11298_Ccin NGH---------------------------SEHHP--PAGHSMPPPKSL--K-LGPFGKK AqueK132_Aque TKK------------------------------F-----EQAKAE---K--G-GLPEVLK MAK_d_Smoe ------------------------------------------------------------ MAK_c_Smoe ------------------------------------------------------------ MAK_e_Smoe ------------------------------SQ-----------PL---QELS-LFPSGK- MAK_b_Smoe ------------------------------------------------------------ MAK_a_Smoe ------------------------------SQ-----------PL---QELS-LFPSGK- GK041_Glam --------------------------------------------S--------------- GK039_Glam ------------------------------------------------------------ M04C9.5_Cele -------------------------R-------N-------------------------- DDB0229430_Ddis ------------------------------------------------------------ MAK_Hsap -N---MPTKPNGTL---------SHK-------SGRRRWGQTIF--KSGD--S----WEE ICK_Hsap KH---PQSKITAGL---------EHKNGEI-KPKSRRRWGLISRSTKDSD--D----WAD CG4588_Dmel YN---VFSKVSASQAPPSLIVRQPQLQPEV-APAPMRLSG-RSRAAAAVQ--DPKMGALK ICK_Mmus KN---LQPKILASL---------EQKNGEI-KPKSRRRWGLISRSTKGSD--D----WAD MAK_Mmus -T---IPVNSVSTL---------GHK-------GARRRWGQTVF--KSGD--S----CDD IME2_Scer ------------------------------------VE-FLNEFVEEDNDDHS----IPD MAK_Spur ------------------------NK-------SGRRKWET-GK--KVED--S----WDD CC1G_11298_Ccin S-----------------------------------SRWALGIFGSEKS--HQ----LPP AqueK132_Aque KSSGSYNNSPLFGS---------HNANGGIVTQHQRKQWQT-RSTAESGD--S----GVD MAK_d_Smoe ------------------------------------------------------------ MAK_c_Smoe ------------------------------------------------------------ MAK_e_Smoe ------------------------------------------------------------ MAK_b_Smoe ------------------------------------------------------------ MAK_a_Smoe ------------------------------------------------------------ GK041_Glam ------------------------------------------------------------ GK039_Glam ------------------------------------------------------------ M04C9.5_Cele ------------------------------------------LP-------------LNK DDB0229430_Ddis ------------------------------------------------------------ MAK_Hsap LE--DY-DFGASHSKKPSMGVF----------------KEK----------------RKK ICK_Hsap LD--DL-DFSPSLSRI-DLK-N----------------KKR----------------QSD CG4588_Dmel SD--DL-DLILGSK--LKTSAK----------------RQR-----------------NA ICK_Mmus LD--DL-DFSPSLTRI-DVK-N----------------KKR----------------QSD MAK_Mmus IE--D--DLGASHSKKPSMEAC----------------KEK-----------------KK IME2_Scer VG-TDS-TISDSIDET-ELS------------------KEI----------------RNN MAK_Spur FDLEGSRGFGGTSAKTKKIGGM----------------KGKALPTI-----GAGNA-VGK CC1G_11298_Ccin VD--EV-T------TT-ALG------------------TRK----------------RSQ AqueK132_Aque SE--GA-QFSNHFNSFPKYKGPPLKPPAPVITSLVPPSKPSAVPLISSLFGGQKRAVKRK MAK_d_Smoe ------------------------------------------------------------ MAK_c_Smoe ------------------------------------------------------------ MAK_e_Smoe ------------------------------------------------------------ MAK_b_Smoe ------------------------------------------------------------ MAK_a_Smoe ------------------------------------------------------------ GK041_Glam ------------------------------------------------------------ GK039_Glam ------------------------------------------------------------ M04C9.5_Cele ETLFEKSD---------NKPLGP---TK-------------------------------- DDB0229430_Ddis ------------------------------------------------------------ MAK_Hsap DSPFRLPEP---VPSGSNHSTGE---NKSL----------PA--VTSL------------ ICK_Hsap DTLCRFESV---LDLKPSEPVGT---GNSA----------PT--QTSY------------ CG4588_Dmel KANILLEDL---FGQLSMDSDSDGKYPHTV----------PPTQQAKS------------ ICK_Mmus DTLCRFESV---LDLKPSESVGT---GTTV----------ST--QASS------------ MAK_Mmus ESPFRFPDS---GLPVSNHFKGE---NRNL----------HA--SVSL------------ IME2_Scer LALCQLPDE-EVLDHSLSNIRQ----------LTNDIEIINK--DEAD------------ MAK_Spur KASLDWEDDDDFLKSPTKHRVGPLS-TRNQ----------PG--VARV------------ CC1G_11298_Ccin SSSTDG--K-SVRDLSPERPQDL---REVQKQQKKEAERINR--EAEK------------ AqueK132_Aque DTLPTI---DSFVGGDDQSRRGQ-----FV----------AK--ETTGGRRDEGLDKFPF MAK_d_Smoe --LCRWVR---------------------------------------------------- MAK_c_Smoe --LCRWVR---------------------------------------------------- MAK_e_Smoe ------------------------------------------------------------ MAK_b_Smoe ------------------------------------------------------------ MAK_a_Smoe ------------------------------------------------------------ GK041_Glam -----------TEGLSV-----------------------AR------------------ GK039_Glam ------------------------------------------------------------ M04C9.5_Cele ------------SNEAKPTAKEIYLSKSK-----YV--PGTV-KNKFKK----------- DDB0229430_Ddis -----------------------FLRKSR-----YSYLNNVSLENVNNNNNNYNSNTTSG MAK_Hsap ------KSD--SELSTAPTSKQYYLKQSR-----YL--PGVNPKKVSLI----------- ICK_Hsap ------QRR--DTPTLRSAAKQHYLKHSR-----YL--PGISIRNGILS----------- CG4588_Dmel ------GKT--STGGHGAGARERDLFGES-----YL--PRPGLRKKATQ----------- ICK_Mmus ------QRR--DTPTLQSSAKQHYLKHSR-----YL--PGINIRNGVLP----------- MAK_Mmus ------KSD--PNLSTASTAKQYYLKQSR-----YL--PGVNPKNVSLV----------- IME2_Scer ------NMEQLFFDLEIPE-KDEFQRKQPFNE---------------HA----------- MAK_Spur ------GLE--SGKSSASSAKQFYMGKAR-----YL--PGMNVKSPRKD----------- CC1G_11298_Ccin ------ERRKLAEKMAREQARAVMSKRNRMLREAVG--EDI---DWSGG----------- AqueK132_Aque SWKSKVHVS--PGVVDKREASNFYLTRAR-----YS--PIVSGKVGF-G----------- MAK_d_Smoe ------------------------------------------------------------ MAK_c_Smoe ------------------------------------------------------------ MAK_e_Smoe ------------------------------------------------------------ MAK_b_Smoe ------------------------------------------------------------ MAK_a_Smoe ------------------------------------------------------------ GK041_Glam ---------------------------NALQRATRA--TDL---NL-------------- GK039_Glam ------------------------------------------------------------ M04C9.5_Cele ------------------------------------------------------------ DDB0229430_Ddis YYNQKLDSTPRLSPRIVRQQQQQILLPLIIQQQPPPQSQPPQSQPPPQSQPPPILTQQQQ MAK_Hsap ------------------------------------------------------------ ICK_Hsap ------------------------------------------------------------ CG4588_Dmel ------------------------------------------------------------ ICK_Mmus ------------------------------------------------------------ MAK_Mmus ------------------------------------------------------------ IME2_Scer ------------------------------------------------------------ MAK_Spur ------------------------------------------------------------ CC1G_11298_Ccin ------------------------------------------------------------ AqueK132_Aque ------------------------------------------------------------ MAK_d_Smoe ------------------------------------------------------------ MAK_c_Smoe ------------------------------------------------------------ MAK_e_Smoe ----------------LRN----------------------------------------- MAK_b_Smoe ------------------------------------------------------------ MAK_a_Smoe ----------------LRN----------------------------------------- GK041_Glam ------------------------------------------------------------ GK039_Glam ------------------------------------------------------------ M04C9.5_Cele ------------------S-L---KWLDLLI--------PYLNCQVSKDTH-QNQIMT-- DDB0229430_Ddis QQQQQQQQQQQLPSKTTIY-----HNT-NHL--------NAPIP---------------- MAK_Hsap ------------------A-----SGK-EI---------NPHTWSNQ-LFP-KSLGPVGA ICK_Hsap ------------------N-----PGK-EFI--------PPNPWSSSGLSG-KSSGTM-- CG4588_Dmel ------------------SSLEVNNGS-H-A--------DSLWWQVQGFGFISPTGEVYM ICK_Mmus ------------------N-----PGK-DFL--------PSNSWSSSGLSG-KSSGTV-- MAK_Mmus ------------------A-----GGK-DI---------NSHSWNNQ-LFP-KSLGSMGA IME2_Scer ------------------D-----IDEDIVL--------PYVNNSNYTHTD-RSHH---- MAK_Spur ------------------S--------GHGL--------PALNKVPSGSAH-RSNILG-- CC1G_11298_Ccin ------------------N-----QERVVDKGTKQASSGPIRQKS--------------- AqueK132_Aque ------------------S-----GAP-RFN--------D-PT----------------- MAK_d_Smoe ------------------------------------------------------------ MAK_c_Smoe ------------------------------------------------------------ MAK_e_Smoe ------QQHSSLASKAFSY-----GFP-DVI--------PCIKR---------------- MAK_b_Smoe ------------------------------------------------------------ MAK_a_Smoe ------QQHSSLASKAFSY-----GFP-DVI--------PCIKR---------------- GK041_Glam --------------------------------------------D--------------- GK039_Glam ------------------------------------------------------------ M04C9.5_Cele -----------------T-------------------------------NGLTG------ DDB0229430_Ddis ---------------------PN--------------------------HQRGI------ MAK_Hsap ELAFK------RSNAEESIIKPI-EKLSCNETFPEKLEDPQG-NLGSYATYNQS------ ICK_Hsap -----------------SVISKV-NSV--------------G-SSSTSSSGLTG------ CG4588_Dmel VYGLHKAWVSERGIRFLSYHKLVTATM--------------G-QDSSYKSGLSQ------ ICK_Mmus -----------------SVVSKI-TSV--------------G-SGSASSSGLTG------ MAK_Mmus DLSFK------RSNAEDSIIKPI-ENLSCTGKSAEQLEDPQG-NLGSYTTYNQT------ IME2_Scer -----------------------------------RG---DN-VLGDASLGDSF------ MAK_Spur -----------------SNYA-------------RRTENNYG-N--GGGNGGGG------ CC1G_11298_Ccin ----------------------------------------MG-NLGNSTLHAASGKYSEP AqueK132_Aque ----------------------------PSPKHSGSIREPNGRNLLPYGQYGEG------ MAK_d_Smoe ------------------------------------------------------------ MAK_c_Smoe ------------------------------------------------------------ MAK_e_Smoe ---------------------PV-AGLGISSKHVCSGED----LSLSTASGGGR------ MAK_b_Smoe ------------------------------------------------------------ MAK_a_Smoe ---------------------PV-AGLGISSKHVCSGED----LSLSTASGGGR------ GK041_Glam ----------------------------------------LL-NGGN--PYAHG------ GK039_Glam ------------------------------------------------------------ M04C9.5_Cele --------------------------------------------T--------------- DDB0229430_Ddis ------------------------------------------------------------ MAK_Hsap ------------------------------------------------------------ ICK_Hsap ------------------------------------------------------------ CG4588_Dmel --------------------------------------------A--------------- ICK_Mmus ------------------------------------------------------------ MAK_Mmus ------------------------------------------------------------ IME2_Scer ------------------------------------------------------------ MAK_Spur ------------------------------------------------------------ CC1G_11298_Ccin PAPPVSFDRYRDWRGTGERVAKARRREYDDDHSMSSSDVHSLSRVSSISFATVDSDPGPS AqueK132_Aque ------------------------------------------------------------ MAK_d_Smoe ------------------------------------------------------------ MAK_c_Smoe ------------------------------------------------------------ MAK_e_Smoe ------------------------------------------------------------ MAK_b_Smoe ------------------------------------------------------------ MAK_a_Smoe ------------------------------------------------------------ GK041_Glam ------------------------------------------------------------ GK039_Glam ------------------------------------------------------------ M04C9.5_Cele --------------------------TKTTTFSAK-------------KEGRTA------ DDB0229430_Ddis --------------------------SP--QF---------------------------- MAK_Hsap --------------------------GYIPSFLKK-------------EVQSAG------ ICK_Hsap --------------------------NYVPSFLKK-------------EIGSAM------ CG4588_Dmel -----------LTHQSSALHRF----SYNSNLFAM-------------NVLAGI------ ICK_Mmus --------------------------SYIPSFLKK-------------EIGSVM------ MAK_Mmus --------------------------GYMPSFLKK-------------EVGSAG------ IME2_Scer --------------------------NSMPDFTPR-------------NFLI-------- MAK_Spur --------------------------NYMPSFSTK-------------QDSSAR------ CC1G_11298_Ccin RLRHHSSFHHAASSRTSRSSLRTSFDDFSPSARSSNSFSLEGSSSLAHEFGAHLNVNPHI AqueK132_Aque --------------------------GRGRQWNGG-------------GE---------- MAK_d_Smoe --------------------------VYHPRFR--------------------------- MAK_c_Smoe --------------------------VYHPRFR--------------------------- MAK_e_Smoe --------------------------NPMLQF---------------------------- MAK_b_Smoe ------------------------------------------------------------ MAK_a_Smoe --------------------------NPMLQF---------------------------- GK041_Glam --------------------------DILPSYAQK-------------KAKTTK------ GK039_Glam ------------------------------------------------------------ M04C9.5_Cele ---------V-----------------------------QTR------------------ DDB0229430_Ddis ------------------------------------------------------------ MAK_Hsap ---------QRIHLAP----------------------LNATASEYTWN----------- ICK_Hsap ---------QRVHLAP----------------------IPDPSPGYS-S----------- CG4588_Dmel ---------IASHPDE----------------------LIASPAQYEFHYSVHDSHSGDV ICK_Mmus ---------QRVQLAP----------------------LAAPPPGYS-S----------- MAK_Mmus ---------QRIQLAP----------------------LGASASDYTWS----------- IME2_Scer ---------------P--------------------------------T----------- MAK_Spur ---------IGGYNEP----------------------WKTT------------------ CC1G_11298_Ccin SGSVSPPPLHMLSLSPTLSPPLSPNPPWIQVQDIKENGLGGQSPPYI-T----------- AqueK132_Aque ------------------------------------------------------------ MAK_d_Smoe ------------------------------------------------------------ MAK_c_Smoe ------------------------------------------------------------ MAK_e_Smoe ------------------------------------------------------------ MAK_b_Smoe ------------------------------------------------------------ MAK_a_Smoe ------------------------------------------------------------ GK041_Glam ---------ELIEL---------------------------------------------- GK039_Glam ------------------------------------------------------------ M04C9.5_Cele ---FEYA----YGSSFCS---SHK-SLF-------------------------------- DDB0229430_Ddis ------------------------------------------------------------ MAK_Hsap ---TKTGRGQFSGRTYNPTA--KN-LNIVN------------------------------ ICK_Hsap ---LKAMRP-HPGRPFFHTQPRST-PGLIP------------------------------ CG4588_Dmel KDQFEHRRGEYVTGRYSLVDPDGH-RRIVD------------------Y----------- ICK_Mmus ---LKAVRP-HPGRPFFHTQPRST-PGLIP------------------------------ MAK_Mmus ---TKTGRGQFSGRTYNPTA--KN-LNIVN------------------------------ IME2_Scer ---LKKSR-----EKFEPHL--S------------------------------------- MAK_Spur ---TKAG----VTNTFGA---ARN-NGL-------------------------------- CC1G_11298_Ccin ---LQN-------RQFSPSP--HSPLDIHN------------------YLQQPPSPFNNP AqueK132_Aque ---ARAG-----GGAFFGNRTRGV-ENVTTTTAAAAAASNNHRGGGGGG----------- MAK_d_Smoe ------------------------------------------------------------ MAK_c_Smoe ------------------------------------------------------------ MAK_e_Smoe ------------------------------------------------------------ MAK_b_Smoe ------------------------------------------------------------ MAK_a_Smoe ------------------------------------------------------------ GK041_Glam --------------DHNDEL--HD------------------------------------ GK039_Glam ------------------------------------------------------------ M04C9.5_Cele ---LF-VF-LLPF----------------------------------------------G DDB0229430_Ddis ----------------------------------------------------------YN MAK_Hsap RAQPIPSVHGRTD----------------------------------------------W ICK_Hsap RPPAAQPVHGRTD----------------------------------------------W CG4588_Dmel TADPLLGFNA--Q----------------------------------------------V ICK_Mmus RPPAAQPVHGRID----------------------------------------------W MAK_Mmus RTQPVPSVHGRTD----------------------------------------------W IME2_Scer ---------------------------------------------------------NSN MAK_Spur ---RAQPVHGRTD----------------------------------------------W CC1G_11298_Ccin SAPAQPPTTGQTPRSANSAINPIFKVVSLDPDVMLFYRCLTYSTALTSPSTTFITAPCRP AqueK132_Aque SVLPNLGLLARVD----------------------------------------------W MAK_d_Smoe ------------------------------------------------------------ MAK_c_Smoe ------------------------------------------------------------ MAK_e_Smoe ---------GEND--------------------------------------------YLA MAK_b_Smoe ---------------------------------------------------------LTC MAK_a_Smoe ---------GEND--------------------------------------------YLA GK041_Glam ---------------------------------------------------------NNM GK039_Glam ------------------------------------------------------------ M04C9.5_Cele ACLSSQYS DDB0229430_Ddis ETTNNSKL MAK_Hsap VAKYGGHR ICK_Hsap ASKYASRR CG4588_Dmel RREPISRY ICK_Mmus SSKYPSRR MAK_Mmus VAKYGGHR IME2_Scer QHFGNVTF MAK_Spur ASKYGGVR CC1G_11298_Ccin TSEFYIPD AqueK132_Aque SSR--YKR MAK_d_Smoe SRNFVKTK MAK_c_Smoe SRNFVKTK MAK_e_Smoe LQVYQGYP MAK_b_Smoe KMATQCVI MAK_a_Smoe LQVYQGYP GK041_Glam LDMIDDMF GK039_Glam -------I