CLUSTAL W (1.83) multiple sequence alignment MAP3K1_Mmus MAAAAGDRASSSGFPGAAAASPEAGGGGGGGGALQGSGAPAAGAAGLLREPGSAGRERAD MAP3K1_Hsap MAAAAGNRASSSGFPGARATSPEAGG---GGGALKASSAPAA-AAGLLREAGSGGRERAD MEKK1_Spur MAIAHLKLE--------------------------------------------------- AqueK225_Aque MEGAKQQK---------------------------------------------------- * * . MAP3K1_Mmus WRRRQLRKVRSVELDQLPEQPLFLAAASPPCPSTSPSPEPADAAAGASRFQPAAGPPPPG MAP3K1_Hsap WRRRQLRKVRSVELDQLPEQPLFLAA-SPPASSTSPSPEPADAAGSGTGFQPVAVPPPHG MEKK1_Spur ----------KA-----------------------------------HLLEPLVVPFASL AqueK225_Aque ------------DVPQPPVQPISL------------------------------------ MAP3K1_Mmus AASRCGSHSAELAAARDSGARSPAGAEP----------PSAAAPSGREM----ENKETLK MAP3K1_Hsap AASRGGAHLTESVAAPDSGASSPAAAEPGEKRAPAAEPSPAAAPAGREM----ENKETLK MEKK1_Spur ADDRGSDHVLAIAGGVEARVLRNHLLMPMEARSLN---------LSRELLLQSSSDKEMK AqueK225_Aque ------------------------------------------------------------ MAP3K1_Mmus GLHKMEDRPEERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPIKGDGSEMNNLAAE MAP3K1_Hsap GLHKMDDRPEERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPVKGDGSEMNHLAAE MEKK1_Spur RMSKLDDPLEKNAIREKLRGK--------------------------------------- AqueK225_Aque --------------------RILFAEDHQWLKVDTH------------------------ MAP3K1_Mmus PQGEGQAGSAAPAPKGRRSPSPGSSPSGRSVKPESPGVRRKRVSPVPFQSGRITPPRRAP MAP3K1_Hsap SPGEVQASAASPASKGRRSPSPGNSPSGRTVKSESPGVRRKRVSPVPFQSGRITPPRRAP MEKK1_Spur -PGVRREGGDAPRTKGPMGSRPGSPTGG---------------------------HRRVP AqueK225_Aque -----------------LSVCPGNGCSV-------------------------------- . **. . MAP3K1_Mmus SPDGFSPY--SPEETSRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSC MAP3K1_Hsap SPDGFSPY--SPEETNRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSC MEKK1_Spur SPNNDCLFTLAVGVLKKRVERALHARLFLLTQSGPNSFLIGGDSPDHKYKVTIGSQNCNC AqueK225_Aque ------------------------------------------------------------ MAP3K1_Mmus GRGAFCIHLLFVMLRVFQLEPSDPMLWRKTLKNFEVES------------LFQKYHSRRS MAP3K1_Hsap ARGTFCIHLLFVMLRVFQLEPSDPMLWRKTLKNFEVES------------LFQKYHSRRS MEKK1_Spur GKGPFCVHLLFVMLRVFKLAEDDNLLWNRTLKNYEVEL------------LFSKYEAMKK AqueK225_Aque ----------------------DVCLYIRALCAHEIDQCPEYCSWCSKVRRWLRYHARSC * *: ::* .*:: : :*.: MAP3K1_Mmus SRIK-APSR----NTIQKFVS-RMSN-CHTLSSSSTSTSSSENSIKDEEEQMCPICLLGM MAP3K1_Hsap SRIK-APSR----NTIQKFVS-RMSN-SHTLSSSSTSTSSSENSIKDEEEQMCPICLLGM MEKK1_Spur KKLKHSPSQ----SSQRSRRS-SQSPSTSHLPRPSSPCPSTGSSDQREDEDLCPICLLEM AqueK225_Aque KPKK-CPYNHFCNETQKKFFRRRMT-IPYSEQWSKGPTSSLH------------------ . * .* . .: :. : .. . .* MAP3K1_Mmus LDEESLTVCEDGCRNKLHHHCMSIWAEECRRNREPLICPLCRSKWRSHDFYSHELSSPVE MAP3K1_Hsap LDEESLTVCEDGCRNKLHHHCMSIWAEECRRNREPLICPLCRSKWRSHDFYSHELSSPVD MEKK1_Spur VEGESLVECKNGCHNKLHHHCVAIWEGECKRQQEPMVCPLCRAIWADCAHENQEAGAASS AqueK225_Aque ------------------------------------------------------------ MAP3K1_Mmus SPTSLRAVQQPSSPQQPVAGSQRRNQESSFNLTHFGTQQIPSAYKDLAEPWIQVFGMELV MAP3K1_Hsap SPSSLRAAQQQTVQQQPLAGS-RRNQESNFNLTHYGTQQIPPAYKDLAEPWIQVFGMELV MEKK1_Spur TP-------HPSTEQGPVEEEAGITESSRL-----------QTFQQKKEGWKEAFDNSLV AqueK225_Aque ------------------------------------------------------------ MAP3K1_Mmus GCLFSRNWNVREMALRRLSHDVSGALLLANGESTGNSGGGSGGSLSAGAASGSSQPSISG MAP3K1_Hsap GCLFSRNWNVREMALRRLSHDVSGALLLANGESTGNSGGSSGSSPSGGATSGSSQTSISG MEKK1_Spur EAMFSRDWGIRENTLHSLSQQLASKLKHSR-E----------GLLNEPHDVETCEQCFQA AqueK225_Aque -------------------------------SSASESSVSS-GSIPVGGAMGTTRHSITA . . : . .: . MAP3K1_Mmus DVV--EACCSVLSIVCADPVYKVYVAALKTLRAMLVYTPCHSLAERIKLQRLLRPVVDTI MAP3K1_Hsap DVV--EACCSVLSMVCADPVYKVYVAALKTLRAMLVYTPCHSLAERIKLQRLLQPVVDTI MEKK1_Spur DMITMESGFMMVAMACSDPVYKVYVAALRVLRTLLMCSHCSTEDQQAQLRKWLQPVMSAI AqueK225_Aque ------------------------------------------------------------ MAP3K1_Mmus LVKCADANSRTSQLSISTVLELCKGQAGELAVGREILKAGSIGVGGVDYVLSCILGNQ-- MAP3K1_Hsap LVKCADANSRTSQLSISTLLELCKGQAGELAVGREILKAGSIGIGGVDYVLNCILGNQ-- MEKK1_Spur LVKSADGNRRTAQLSVSAMFELARGDSGELAVSKELSCSSCIGLGSLDYILSCLISDIQI AqueK225_Aque ------------------------------------------------------------ MAP3K1_Mmus -AESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTDVSQAEPVEIRYKKLLSLLTFALQS MAP3K1_Hsap -TESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTDVSQAEPVEIRYKKLLSLLTFALQS MEKK1_Spur NVGETSWQHILGCLCVLERVFSDFPERFV---ITEDHSSEVEKASKIECLVSIATCVSSY AqueK225_Aque ------------------------------------------------------------ MAP3K1_Mmus IDNSHSMVGKLSRRIYLSSARMVTAVPAVFSKLVTMLNASGSTH-FTRMRRRLMAIADEV MAP3K1_Hsap IDNSHSMVGKLSRRIYLSSARMVTTVPHVFSKLLEMLSVSSSTH-FTRMRRRLMAIADEV MEKK1_Spur LNSSHTRMCKIAKKISVTVAKILVADASGFARICDMMRTLESREVGSRMLRRLQKILDEY AqueK225_Aque ------------------------------------------------------------ MAP3K1_Mmus EIAEVIQLGVEDTVDGHQDS-LQVLAPASCL---ENSSLEHTVHREKTGKGLSATRLSAS MAP3K1_Hsap EIAEAIQLGVEDTLDGQQDSFLQASVPNNYLETTENSSPECTVHLEKTGKGLCATKLSAS MEKK1_Spur EGAQDE---------------------------AAREREDAAVHGHDEGGGVCDDERDGR AqueK225_Aque ------------------------------------------------------------ MAP3K1_Mmus SEDISDRLAGVSVGLPSST-----TTEQPKPAVQTK--GRPHSQCLNSSPLSH-AQLMFP MAP3K1_Hsap SEDISERLASISVGPSSSTTTTTTTTEQPKPMVQTK--GRPHSQCLNSSPLSHHSQLMFP MEKK1_Spur RNGM---LSNI------------------------------------------------- AqueK225_Aque --------------------------AGPGPSSTCRWGCSEEAKCCESGNC--------- MAP3K1_Mmus APSAPCSSAPSVP-----DISKHRPQAFVPCKIPSASPQTQRKFSLQFQRNCSEHRDSDQ MAP3K1_Hsap ALSTPSSSTPSVPAGTATDVSKHRLQGFIPCRIPSASPQTQRKFSLQFHRNCPENKDSDK MEKK1_Spur -QDSPCAAE-------NTNVSSRRY----------------------------------- AqueK225_Aque ------------------------------------------------------------ MAP3K1_Mmus LSPVFTQSRPPPSSNIHRPKPSRPVPGSTSKLGDATKSSMTLDLGSASRCDDSFGGGGNS MAP3K1_Hsap LSPVFTQSRPLPSSNIHRPKPSRPTPGNTSKQGDPSKNSMTLDLNSSSKCDDSFGCSSNS MEKK1_Spur ---------------DHAITPSRPSLRDNADGCFP------------------------- AqueK225_Aque ---------------CHEPHPHDM--------ASPSSSSSSLVLSSSY-ITS-------- * * . MAP3K1_Mmus GNAVIPSEETVFTPVEDKCRLDVNTELN-SSIEDLLEASMP-SSDTTVTFKSEVAVLSPE MAP3K1_Hsap SNAVIPSDETVFTPVEEKCRLDVNTELN-SSIEDLLEASMP-SSDTTVTFKSEVAVLSPE MEKK1_Spur ------------------TRTDSNEQTNVSDLSDLSSASPTTPCDNPICFKSEVAS-SPK AqueK225_Aque ------------------------SYSQ-DIIQRALDERLP-ETETEV------------ : . :. . . :. : MAP3K1_Mmus KAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSA-SQDALPIVPQLQVENGEDIII MAP3K1_Hsap KAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSA-SQDALPIVPQLQVENGEDIII MEKK1_Spur KRMAAFDFTLPGVGSKNCKDEVEAEEAEALAIAMEASMHTQCVLPCVPGLRTERDGDVII AqueK225_Aque ------------------KAYIETKKQIRLAL---------------------------- * :*::: **: MAP3K1_Mmus I--QQDTPETLPGHTK-AKQPYREDAEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVT MAP3K1_Hsap I--QQDTPETLPGHTK-AKQPYREDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVT MEKK1_Spur KIDHKNSTEEVDGVVSPRSKQYTESQNWTKGAILGTGAFSSCYMARDVKTGTLMAVKQIS AqueK225_Aque ---------------LERHKFYQEGVHWERIKQLGCGSSGTTYCIRDRETSFWLALKE-- : * *. .* : :* *: .: * :* *. :*:*: MAP3K1_Mmus YVRNTSSEQEEVVEALREE---IRMM-GHLNH-PNIIRMLGATC----EKSNYNLFIEWM MAP3K1_Hsap YVRNTSSEQEEVVEALREE---IRMM-SHLNH-PNIIRMLGATC----EKSNYNLFIEWM MEKK1_Spur FCRNNAGDQEDTMEEIKKE---IKLM-ATFDH-PHIVRLMGATQ----HDAHFNVFVEWM AqueK225_Aque --------EQESLTAVNETLISLRLSSSSKDHPPNIVEFYGASLLPLQVETKLQLFLELM ::: : :.: ::: . :* *:*:.: **: .:: ::*:* * MAP3K1_Mmus AGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRI MAP3K1_Hsap AGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRI MEKK1_Spur PGGAVSTLLKDFGAFSNAVTVKYIHQVCLGLAYLHDNRVIHRDLKGANLLMDSTGHHLRI AqueK225_Aque PCCLQ-SYLYNGGPLSVEDAHNYACQLFDALDYLHA----------GNLLIDENVQRLKV . * . *.:. . :* *: .* *** .***:*.. ::*:: MAP3K1_Mmus ADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAK MAP3K1_Hsap ADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAK MEKK1_Spur ADLGTAGKMNADITRTDEFKGQFLGTISFMAPEVLRGEPYGRSCDIWSVGCCIIEMCTTK AqueK225_Aque TDFGCSQVLEDSHQGYCMRGDANAGTVHYNPPEHYSEFRCSYALDIWQAGCCIIAMVTGR :*:* : : . . **: : .** . : *:*..**.** * : MAP3K1_Mmus PPWNAE------------KHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQ MAP3K1_Hsap PPWNAE------------KHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQ MEKK1_Spur PPWNNT------------AISNHYQLLFKIASANGPPPIPESLSPALRDITLRCLEAEPS AqueK225_Aque RPWRSMYLDCRERRYRAEVQQSQIQQ---ICKVPYSHHVPGFLDPALQQLVQQCLSIDYR **. ..: *... . :* *.*.*:::. :**. : MAP3K1_Mmus DRPPSRELLKHPV----------------------------------------------- MAP3K1_Hsap DRPPSRELLKHPV----------------------------------------------- MEKK1_Spur ARPGVMELLKHPA----------------------------------------------- AqueK225_Aque RRPSLKDCLGLLAQSDVVSDSCKGQWLSHLGLQPTCFSSSSSPAPKSFLVDIYLGSYVHY ** : * . MAP3K1_Mmus -------------------------------------FR--------------------- MAP3K1_Hsap -------------------------------------FR--------------------- MEKK1_Spur -------------------------------------FT--------------------- AqueK225_Aque SHYSLLPGWLGSVSCDSHVTYSQLHELIRNSIPVTQLFRSMEFGLCDNLPNLIWQKSSIN * MAP3K1_Mmus -------------------------------TTW MAP3K1_Hsap -------------------------------TTW MEKK1_Spur ------------------------------QMKR AqueK225_Aque HGTSDTTSEDIIQLSRPKGTDAIDSSKGVVVIVE