CLUSTAL W (1.83) multiple sequence alignment MEKK15_Mmus MNKNR---------------------LIHDFLGVVSRGDVECICGLIPEVHSVLGNLDFQ MEKK15_Hsap ------------------------------------------------------------ MEKK15_Spur MISST------------------------------------------------------- AqueK226_Aque MNGGTGKRTTYHKIAYDVLQSRRPQSAVDSLLEAAEIGDDRKLMELVSKYRTII---NLK MEKK15_Mmus HPQTGNTPLITAAEENLAEVVEILLEGGADITLCNYSNQTALHVANGDIQRQLLAGKGIQ MEKK15_Hsap ------------------------------------------------------------ MEKK15_Spur ------------------------------------------------------------ AqueK226_Aque CVSSGDTALITAARNGHSNIVEYLMKSGADPTLQNDIGENALDVAPPHIRDILLSQLSKE MEKK15_Mmus APQ--MQLLRSSWLGDLKQLRHLLACEEFLDINFPNSHGLTPLMLAVRDVDLFESLD--L MEKK15_Hsap -----MQLLQSSWQGDLEQVQHLLASEEFLDINFPNQHGLTPLMLAVRDVDLFESLD--M MEKK15_Spur ------------------------------------------------------------ AqueK226_Aque RPSTANRLLQAAWLGDSVTVKKNLS-GGIINVNCKNSEGLTPLLLVTRDIKTFDKVHRVM MEKK15_Mmus LTAYRPDEVLAELLRHHADPKLCDFSGKSAIHYVSQIESWRKQQLLDILMDSMPRPERHA MEKK15_Hsap LTVYKPVEVLSQLLRHHADPKLCDFSGKSAIHYVSQIESSKKQQLLDILMSSMPKPERHA MEKK15_Spur ------------------------------------------------------------ AqueK226_Aque KTDYDPLGVMQELLKHKADLRACDSNGRTALHLISNEGS--------------------- MEKK15_Mmus ESLLDICHEAGSTPME-MTVSQTENLTLQSISSSEDFDLEDDFSPFILAREGAAPRG--E MEKK15_Hsap ESLLDICHDTNSSPTDLMTVTKNQNIILQSISRSEEFDQDGDCSHSTLVNEEEDPSGGRQ MEKK15_Spur ------------------------------------------------------------ AqueK226_Aque -----------SSVG-AVQAKKVVSLLLQNGSSTNITDKNGY-TPLHIAA---------- MEKK15_Mmus NWPRRTEGVEIIVTFPPD--PLQEASQEDLKESNQVTSEHQEREQVHPVSPPDDAEMVGL MEKK15_Hsap DWQPRTEGVEITVTFPRDVSPPQEMSQEDLKEKNLINSSLQEWAQAHAVSHPNEIETVEL MEKK15_Spur ------------------------------------------------------------ AqueK226_Aque ------------------------------------------------------------ MEKK15_Mmus TGRMLTTQPSLLKTDGSSEELCGVDVALSPPRPCLDSSLAASAAGEVAPCVLKEQQRQSD MEKK15_Hsap RKKKLTMRPLVLQKEESSRELCNVNLGFLLPRSCLELNISKSVTREDAPHFLKEQQRKSE MEKK15_Spur ------------------------------------------------------------ AqueK226_Aque ------------------------------------------------------------ MEKK15_Mmus EFPTSDISYSSRRTGLPLPPLSCLPMRSCIFNMEKSPKSPRHRERKVPSLSLSVPKLLEP MEKK15_Hsap EFSTSHMKYSGRSIKFLLPPLSLLPTRSGVLTIPQNHKFPKEKERNIPSLTSFVPKL--- MEKK15_Spur ------------------------------------------------------------ AqueK226_Aque ------------------------------------------------------------ MEKK15_Mmus LSRPLSQSAEFSSSKNHQEVTQEGPVEHTLRGSNCTLWSRNMCSFRKSGKQG----VAES MEKK15_Hsap -SVSVRQSDELSPSNEPPGALVKSLMDPTLRSSDGFIWSRNMCSFPKTNHHRQCLEKEEN MEKK15_Spur ------------------------------------------------------------ AqueK226_Aque ------------------------------------------------------------ MEKK15_Mmus WPSQEMEGWDKTKTSGFKEGPSLFSCESVKEDTTPTERERDSGYHVSEM---------QR MEKK15_Hsap WKSKEIEECNKIEITHFEKGQSLVSFENLKEGNIPAVREEDIDCHGSKT---------RK MEKK15_Spur ------------------------------------------------------------ AqueK226_Aque -----------------KNGHTAIIVALLEEG------ETDIDCRGGENRDTPLIISVRE MEKK15_Mmus -GGEDSQYLSSRKKESWTARVVERDSGVEHPILCKLLEVSNSEMTPAEEKEIGNENVPDA MEKK15_Hsap PEEENSQYLSSRKNESSVAKNYEQDPEIVCTIPSKFQETQHSEITPSQDEEMRNNK-AAS MEKK15_Spur ------------------------------------------------------------ AqueK226_Aque GHKETAEYLLSKGADVTLT----------------------------ADS--GDT----- MEKK15_Mmus KSNSVHKSG--------AMEPHAASEEVSVPKNGPSVNSDGPAEEL-EGHRDIEQNRKIP MEKK15_Hsap KRVSLHKNE--------AMEPNNILEECTVLKSLSSVVFDDPIDKLPEGCSSMETNIKIS MEKK15_Spur ------------------------------------------------------------ AqueK226_Aque -ALSVAKTSSMTALIKDAWDKSIASEPIGAPCEGSGTESDSN----------TDINTDLN MEKK15_Mmus MEEETNPEMNGVVPLTHIAFPGEGTSKGPARAEPHLQRRKRPAQNSNSFNLLAHREHDKL MEKK15_Hsap IAERAKPEMSRMVPLIHITFPVDGSPKEPVIAKPSLQTRKGTIHNNHSVNIPVHQENDKH MEKK15_Spur ------------------------------------------------------------ AqueK226_Aque ADTDTDTDLAGTVTA--------------------------------------------- MEKK15_Mmus QTNTHRTKLDSRTKARNRAPPNLMVSIQASIKPNMHKNSIKTQVFPALELIDHRPHPSSK MEKK15_Hsap KMNSHRSKLDSKTKTSKKTPQNFVISTEGPIKPTMHKTSIKTQIFPALGLVDPRPWQLPR MEKK15_Spur ------------------------------------------------------------ AqueK226_Aque --------------------PFFITQNNGQLRSSRSLSEIATRSIERVG----------- MEKK15_Mmus FQRRAPL-TEKKSTHQTQKPKKQAFPRIGKHAGIKKPGIPLSAETTDPRLHFLDLKYSDM MEKK15_Hsap FQKKMPQIAKKQSTHRTQKPKKQSFPCICKNPGTQKSCVPLSVQPTEPRLNYLDLKYSDM MEKK15_Spur ------------------------------------------------------------ AqueK226_Aque -------------------------------------------QETMTRLESVDNNDKYM MEKK15_Mmus FKEINSASNGPGIYEMFGTPVYCHIREAERHDHRCYREIRTAPSGRCVVNKCQSSESDRC MEKK15_Hsap FKEINSTANGPGIYEMFGTPVYCHVRETERDENTYYREICSAPSGRRITNKCRSSHSERK MEKK15_Spur ------------------------------------------------------------ AqueK226_Aque -------------TRQSSTPDHSQYSEVEADDEQEYNKISKRH-----------TPARRR MEKK15_Mmus SNSRARLLQKRQHIKPPKPLHGLRQKHRGFISKDKGCKDMGGH-----TEDSVSEPDGQM MEKK15_Hsap SNIRTRLSQKKTHMKCPKTSFGIKQEHKVLISKEKSSKAVHSNLHDIENGDGISEPDWQI MEKK15_Spur ------------------------------------------------------------ AqueK226_Aque SLLRQSLITSKRNTTNAES--ALRRSQLAL------------------------------ MEKK15_Mmus KSPGNDFLSSKDDAQLMHLIPIPELSPEQKAPAPVSDLSIVEEIFTE---ECADEEGILN MEKK15_Hsap KSSGNEFLSSKDEIHPMNLAQTPEQSMKQNEFPPVSDLSIVEEVSME---ESTGDRDISN MEKK15_Spur ------------------------------------------------------DRSLST AqueK226_Aque -----------------------------SGGGSSSTLSVVKEEYSSSDKTLTPTDGRPD . MEKK15_Mmus DDSLTQSLGDLKEPEGLHPQ------APLVPSENS-WAVLSEKRSGKRVSPEKHNVEPLD MEKK15_Hsap NQILTTSLRDLQELEELHHQ------IPFIPSEDS-WAVPSEKNSNKYVQQEKQNTASLS MEKK15_Spur NTT--------------------------------------------------------- AqueK226_Aque NDDTIKSRRDLKSRDNLIKSRCDSRHDTMIPSYYDELAT--ASNNDEYIT---------S : MEKK15_Mmus KINAEQMFPGYLEFDSLSEKSKTLVSFSSCSFQENLERAPSPTEQHWARSLEQDSLENNS MEKK15_Hsap KVNASRILTNDLEFDSVSDHSKTLTNF---SFQAKQESASSQTYQYWVHYLDHDSLANKS MEKK15_Spur ------------------------------------------------------------ AqueK226_Aque NIGSRTPFPYHLLADTSGSG---------------------------------------- MEKK15_Mmus TTYQTFGK-------ISQEILDPGKNEELTDELLGCLVEELLALDEKDNNSCQIMTNEAD MEKK15_Hsap ITYQMFGKTLSGTNSISQEIMDSVNNEELTDELLGCLAAELLALDEKDNNSCQKMANETD MEKK15_Spur ------------------------------------------------------------ AqueK226_Aque --------------PRKTSGIDSGH----------------------------------- MEKK15_Mmus AKNLNLVFSRRGNTIEELGRETTDVKLQRCINGFRIYD-EENFLTSNEKKTLSDKSLNHE MEKK15_Hsap PENLNLVLRWRGSTPKEMGRETTKVKIQRHSSGLRIYDREEKFLISNEKKIFSENSLKSE MEKK15_Spur ---------------------------------------------------VSE--SEGT AqueK226_Aque ----------------------------------EG-ESEESE-SSSEEEEEREE-QEET : : MEKK15_Mmus EAIFWTKGEILGRGAYGTVYCGLTSLGQLIAVKQVALDTSDKLATEKEYRKLQEEVDLLK MEKK15_Hsap EPILWTKGEILGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLK MEKK15_Spur ELLHWKKGNLLGKGAFGTVYCGLTNTGQLLAVKQVELSEIDKEKAKQQYLKLQEEVQLLK AqueK226_Aque EELRWKKGKLLGRGAYGKVYEGLLDTARLIAVKEVELEVEDNEKALVQFKKIQLEVDILR * : *.**::**:**:*.** ** . .:*:***:* *. :: : :: *:* **::*: MEKK15_Mmus ALKHVNIVAYLGTCLEENTLSIFMEFVPGGSISSIINRFGPLPEMVFCKYTRQILQGVAY MEKK15_Hsap ALKHVNIVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAY MEKK15_Spur TLRHKNIVGFLGVSLEDNVVNIFMQFIPGGSIASLLARFGSLDETVFCRYTKQILEGTQY AqueK226_Aque SLSHKNIVQYLGTSINETIVYIFMEYITGGSLQSILKRFGSLNEKTIVRYVRQMGRGLNY :* * *** :**..:::. : ***:::.***: *:: ***.* * .: :*.:*: .* * MEKK15_Mmus LHDNCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLAWAGLNGTHSDMLKSMRGTPYWMAP MEKK15_Hsap LHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAP MEKK15_Spur LHENNVIHRDIKGANIMLMSTGVIKLIDFGCAKRLCIQISRS--QNVLKSMRGTPYWMAP AqueK226_Aque LHNNGVIHRDIKGANVMVSAHGTVKLIDFGCAKRHCLDQSLG-----FHSVRGTPYWMAP **:* *:****** *:*: . * :********:* . . ::*::******** MEKK15_Mmus EVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPARFSEP MEKK15_Hsap EVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSEN MEKK15_Spur EVIMETGHGKKSDIWSIGCTVFEMATRKPPWADMPPMAAIFAIGSGDP-VPQLPVKFSED AqueK226_Aque EVICGRGYGRKSDIWSLGCTMYEMIFTRPPWGDLPPEAAMFKIGLGQS-LPPLPKNSSME *** *:*:******:***::** :** ..: **:* ** :* ** . * MEKK15_Mmus AADFVRLCLTRDQHERPSALQLLKHSFLKR------------------------------ MEKK15_Hsap AADFVRMCLTRDQHERPSALQLLKHSFLERS----------------------------- MEKK15_Spur ARMFVNACLTRDQDERATASELLKHPFIKRRKERGREHYHQTRISSTSLEDGPIVFREQP AqueK226_Aque LISLYTACLKSDPGQRPTAQEVLDHAFLQK------------------------------ : **. * :*.:* ::*.*.*::: MEKK15_Mmus -------------------S MEKK15_Hsap -------------------H MEKK15_Spur ISRDSAESKGRKNYAPHEFR AqueK226_Aque -------------------K