CLUSTAL W (1.83) multiple sequence alignment B0414.7_Cele MSSNQYKRIKRC--KSMPTIDDETVG---------------------------------- Mekk1_Dmel MSNRRRVR----------TIDYLALQQS-LRLQKTPAATTNAEEQVAREEENGNGHHSTV MAP3K4_Mmus MRDAIAEP-----------V------PP-PALADTPAAAM-------------------- MAP3K4_Hsap MREAAAAL-----------V------PP-PAFAVTPAAAM-------------------- MEKK4_Spur T----------------------------------------------------------- AqueK228_Aque MAEGEGEEESYFPDHVVEGIDEEASGETDDKLSSLPVDSTSEEE----EEESG------- B0414.7_Cele -------------------------------------EAVR----------K-------- Mekk1_Dmel TAETPPTPPIPPIPPIRLRREQSVEE-DVARVEYRVKQTPSRPVQMTRNRIGALEEDLPP MAP3K4_Mmus -EELRPAPPPQPE-P-------DPECCPAARQECMLGESAR----------KSMESDPED MAP3K4_Hsap -EEPPPPPPPPPP-PPEPETESEPECCLAARQEGTLGDSAC----------KSPESDLED MEKK4_Spur ------------------------------------------------------------ AqueK228_Aque ------------------------------------------------------------ B0414.7_Cele -----------------------------------------T------------------ Mekk1_Dmel EDELAAHYEAFGTTPPRTRLKIKNRDWER-KQKVVNVTASADL------------PASVG MAP3K4_Mmus FSDETNTETLYGTSPPSTPRQMKRLSAKH-QRNSAGR------------------PASRS MAP3K4_Hsap FSDETNTENLYGTSPPSTPRQMKRMSTKH-QRNNVGR------------------PASRS MEKK4_Spur -----------------TPTQQQQLVRLR-QKNSLNR------------------VVTRN AqueK228_Aque ----SYDEGLTGSTPPSNSRL-HKMSRRGHKYKTSRKIMSSSSENQSPYRVKDITRAKSA B0414.7_Cele IMKKVATRMNTSK-RE----Y---MGRRSLGVAT---VS---TKIKRKKSKTERDRDMYD Mekk1_Dmel GTPKKTRTARSRV-LRRNTMDCALLNE--MFVNDESK--RTDKRLQSLLRDSEREMKNSL MAP3K4_Mmus NLKEKMNTPSQSP-HKD-------LGKGVETVEEYSY--KQEKKIRATLRTTERDHKKNA MAP3K4_Hsap NLKEKMNAPNQPP-HKD-------TGKTVENVEEYSY--KQEKKIRAALRTTERDRKKNV MEKK4_Spur SLKMEMEALIQKI-IQEIIQDLMNFGQSAQNTKQKLH--QRKMRSIHLDRTSEREFKQKA AqueK228_Aque DWSESVSTPSDSLIHK----RYSLTGEGEEISSELCQVSLCDKKRKEKSRQMERNVKSAI . .. : **: . B0414.7_Cele DMYDDEGYAASPTSSSSCTYRCIPILERSNRNSQNYLPSAESSSSDSNDRVISHPNHRPI Mekk1_Dmel --ATTA-VAA--PRGNS-------------------FHETAHPLESLDQ-IMPLNS-EAM MAP3K4_Mmus --QCSF-MLD--SVAGS-------------------LPKKSIPDVDLNKPYLSLGCSNAK MAP3K4_Hsap --QCSF-MLD--SVGGS-------------------LPKKSIPDVDLNKPYLSLGCSNAK MEKK4_Spur --I---------TYDGS-------------------ELHVPLTPTHVFRPFDSLPSPNLK AqueK228_Aque --NHPE-MST--SPSSTANYTN----------TEPPRPSFSSPS-PSNPPYPVLAHSHSS . .: . . B0414.7_Cele LLY--------------------------------------------------------- Mekk1_Dmel API---P------LR----------------IA--SKVVESCNRYRCVSSRPIGYR---- MAP3K4_Mmus LPV--------------------------------------------------------- MAP3K4_Hsap LPV--------------------------------------------------------- MEKK4_Spur ID---------------------------------------------------------- AqueK228_Aque PPPSSHPPPSHPPSHPPPSHSPLPPPSSPPALPPPSPSHPPPPSYSPSSPSPLSYNVPPP B0414.7_Cele -STALS------------------------------------------------------ Mekk1_Dmel -SSAPP------------------------------------------------------ MAP3K4_Mmus -SMPMP------------------------------------------------------ MAP3K4_Hsap -SVPMP------------------------------------------------------ MEKK4_Spur ------------------------------------------------------------ AqueK228_Aque SSYPLPPPNQSPSVDTSLYPPPIDPHYLPTGDSPVLYPLPHLSPETYSSKLSSSPYPSKL B0414.7_Cele ---------------------------------------MA---------P-QQNLSVES Mekk1_Dmel ---------------------------------------LA---------F-AAQLPAGM MAP3K4_Mmus ---------------------------------------IA---------R--------- MAP3K4_Hsap ---------------------------------------IA---------R--------- MEKK4_Spur ------------------------------------------------------------ AqueK228_Aque GKVGSPNPMLSPGIPSHMRPSFSYTTDNIIPYYSLSSLSHAPPGVSIERSQSDAQLSLTL B0414.7_Cele -LSDALDELEGADRSKLHMEITQFLK------KADGEKS-------KQIQMSQRLMNCPQ Mekk1_Dmel LRSDGRATPGLGKRKDFHETFANLIKLGSVDRQDA-KLS-------QEE---HTW----- MAP3K4_Mmus TARQTSRTDCPADRLKFFETLRLLLKLTSVSKKKDREQR-------GQENTAAFW----- MAP3K4_Hsap PARQTSRTDCPADRLKFFETLRLLLKLTSVSKKKDREQR-------GQENTSGFW----- MEKK4_Spur ----------SSERVDFHRTFSALIRMGSAKKENSQEITQRIRR--QDGMTQDVF----- AqueK228_Aque SSSSSHSMHCPPDRKQFYRNFSKRLKMIAKRQQQSSTQPGHIPRQHSEDLNAKNP----- .* .:. : :: : : B0414.7_Cele FGQTMRLIVEESEHTRYTFENILWLILKSYFSTTSTGRDVMIGKSEWIAEDEKIVKARKQ Mekk1_Dmel ---------------QTELKDLIWLELQAWQADRTVE-----------QQDKYLFEARQG MAP3K4_Mmus ---------------FNRSNELIWLELQAWHAGRTIN-----------DQDLFLYTARQA MAP3K4_Hsap ---------------LNRSNELIWLELQAWHAGRTIN-----------DQDFFLYTARQA MEKK4_Spur ---------------QMQWNEILWLELTAYHNELSIT-----------DQDLHLINARKK AqueK228_Aque ---------------FGPDNEQLRMELRAYLNNHTLE-----------DQEEADYQLQCE :: : : * :: : :: : B0414.7_Cele YMMVMDMIKEFKFEVGKND---KD--D--------------------------------- Mekk1_Dmel VSDLLTHIINYKFQPRYRREPSLISLDSGTH----------------------------- MAP3K4_Mmus IPDIINEILTFKVNYGSIA---FSSNGAGFN----------------------------- MAP3K4_Hsap IPDIINEILTFKVDYGSFA---FVRDRAGFN----------------------------- MEKK4_Spur VAEVFDEIMKFKYQSGRSS----SSSGSSSH----------------------------- AqueK228_Aque SGSILYRIIHYSFSSDSTLSGY-FR-GLSESAKSLPAQLNELKRGSLRRRKMMPLQENKE :: * :. . B0414.7_Cele ----------------SPFESLN-----------------------RR------------ Mekk1_Dmel --------SDSNSNA-----S-------------------SPLPSKM-------CQGC-- MAP3K4_Mmus --------GPLVE------------------------GQCRTPQETN-------RVG--- MAP3K4_Hsap --------GTSVE------------------------GQCKATPGTK-------IVG--- MEKK4_Spur --------GDSVETS-----QMN---------GNACDTCCNPNPVQRRHPSVSDNGFCMP AqueK228_Aque EEEEVEEKGEEEEGDETPLTSINNPSVRWEDGGGETEGEDEYGPQTL-IQQESNDSDALS B0414.7_Cele M-EFSP-DYCENLRDARKRVSDVLDKYETLVDLFPNQNALWKVVELDRGEAEKKLLEGRM Mekk1_Dmel -MSLYCKDCMDHQKLALREVEGMLTRLEAAEALYPSSQAMGALH----PIYKSQSFVGRI MAP3K4_Mmus -CSSY-HEHLQRQRVSFEQVKRIMELLEYMEALYPSLQALQKDY----ERYAAKDFEDRV MAP3K4_Hsap -YSTH-HEHLQRQRVSFEQVKRIMELLEYIEALYPSLQALQKDY----EKYAAKDFQDRV MEKK4_Spur LSAAL-NAYITDTSEAWYKVHALLEDLEKVQLLYPNSKALQNDC----VELSTPEFTKRL AqueK228_Aque VEFSFDNFLSEEQLQAIEDVDSLLSDLERVELLYASSKRVVD------KQYQQLPFKRRR : * :: * *:.. : : : * B0414.7_Cele TSMRVWLNTLDDLTDKFKALGVLFEIETMPDAE--------------------------- Mekk1_Dmel KSMCLWYNITKQNKLKLSILGKILARLQDEKFSWPVCTSSYIATDSGSSSA----SGVEN MAP3K4_Mmus QALCLWLNITKDLNQKLRIMGTVLGIKNLSDIGWPVFEIPSPRPSKGYEPE----DEVED MAP3K4_Hsap QALCLWLNITKDLNQKLRIMGTVLGIKNLSDIGWPVFEIPSPRPSKGNEPE----YEGDD MEKK4_Spur ETLCLWMNITNDISHKFELTSQILGVVDLEGLWWPYLDLPGYCVENPFQSESCIESEMDD AqueK228_Aque AALVLWLKITEGLAKHLVNLSKWFGVIVNP------------------------VRRSED :: :* : . :: . : B0414.7_Cele -EC--------------------------------------------------------- Mekk1_Dmel DDSAVNSMDSSKPPSMAGSASRKGVTPCHKVQFMLNDATHVPGETSSSNESTSTEVSQ-W MAP3K4_Mmus TEVELRELESGTEESDEEPT------PSPRV----------PE----LRLSTDAILDS-R MAP3K4_Hsap TEGELKELESSTDESEEEQI------SDPRV----------PE----IRQPIDNSFDI-Q MEKK4_Spur EVKPMNEFDDSTPNLEGTEQP-----ALTST----------PQ----YRSPRT------- AqueK228_Aque DLIPCN-VEPGTPSRQG-SGGSGGNPPLPTPPLFTSDISVDPEESLS-LSALSFASSFFQ B0414.7_Cele -----------------------WFRPLDENNKIFALE-DVRAVFLEYVKNSLNLKGMKK Mekk1_Dmel SSEC---SHSHMRKGSMHDINIFSVEPLGTCSSNGTGE-QSTGLYRKFIENVLKSRGLAK MAP3K4_Mmus SQGC---VSRKLERLESEEDSIGWGTAD--CGPEASRH-CLTSIYRPFVDKALKQMGLRK MAP3K4_Hsap SRDC---ISKKLERLESEDDSLGWGAPDWSTEAGFSRH-CLTSIYRPFVDKALKQMGLRK MEKK4_Spur ---D---ESPRTNRIFSE------------CHFSFDYD-SSTSIYRPFVDRSLKHQGLRK AqueK228_Aque TQNSISSSRGTLQRLFSSRN-IY----------SIDEERVSSKGYSRFVDQVLKRKSLDW . : ::.. *: .: B0414.7_Cele VLSRVEKIIELTLVKTAILMQKPPT----SYAAA-----------TA-----SNGPSF-- Mekk1_Dmel SLAFLHKLHNVALYKAHIALEKPGA---EDF-DYE-----SDAESIE-----EDVPRL-- MAP3K4_Mmus LILRLHKLMNGSLQRARVALVKD--DRPVEFSDFPGPMWGS---D---------YVQL-- MAP3K4_Hsap LILRLHKLMDGSLQRARIALVKN--DRPVEFSEFPDPMWGS---D---------YVQL-- MEKK4_Spur MTKRLDKMLGHTMRKIRLALEKMKLDTLIEFMDHKCPMWYSLQSDIDLTLKPSGTPQF-- AqueK228_Aque LIEKLIKSIKPILKTAKEAMKQLEV--EEDKSEDSDNE--DNSSFLE-RLSPFRLIHFGG : * : : : . : B0414.7_Cele P-FSQTMKDRY--GDMIEWRFCNSTSISLNLPPLNNLFFFLVAVPMQLVVHWLEIRAATE Mekk1_Dmel --DPEISREQV--VELRTYGYWSEEAQSINLPSYIPTFVFLSGIPLQFMHEFLRMRLETR MAP3K4_Mmus SGTP-PSSEQKC--S---AVSW-EELRAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQR MAP3K4_Hsap SRTP-PSSEEKC--S---AVSW-EELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQR MEKK4_Spur FETPSPSTEQTHGTQLQSHGAWSKEFQDMSLPSFMPAYLFLVRIPLDVMHECLRFRLEHK AqueK228_Aque VSTPGPAQMKRA--SSVAPKCWNDEFQDMNLPPFAEQYLRLTRVPLDIMQESMRLRTEVN . . . . :.**. :. * : ::.: . :.:* . B0414.7_Cele PPDSCLLDELTFDAMITDSRDCVEEAVRIKKNYLTILQS-MCSKCAMPG-FL-YPL-KYN Mekk1_Dmel PV-RP--NPLSLEQLMKELREGLTLALTHRERYQRHITTALVENEAEL-GSYISILNHYD MAP3K4_Mmus PAGEP--SLLSIKQLVRECKEVLKGGLLMKQYYQFMLQE-VLGG----LEKTDCNMDAFE MAP3K4_Hsap PAGEP--SLLSIKQLVRECKEVLKGGLLMKQYYQFMLQE-VLED----LEKPDCNIDAFE MEKK4_Spur PEADP--SRHSIQQLIREYKEVIGACTHVKQYYHDMVSA-VTLGDVRAQEHVDNDIDDYE AqueK228_Aque K--SP--TPYSVGMLVQESCVTLKKAVRVRKFYRSKVRL-LIANDPSGAELVDNDMACYE :. :: : : :: * : : : :: B0414.7_Cele TYVLDVFKKYIHYVKCWSNC-DSVRKDPPLLFSRLEMEWSSAVQCAKSVKSALELLCTTY Mekk1_Dmel ATVRKTFELYLEYIDQLV--LVAVPEG--NQKSVLEKEWMFTKLISPMIKGMHTLASQKF MAP3K4_Mmus EDLQKMLMVYFDYMRSWIQMLQQLPQASHSLKNLLEEEWNFTKEITHYIRGGEAQAGKLF MAP3K4_Hsap EDLHKMLMVYFDYMRSWIQMLQQLPQASHSLKNLLEEEWNFTKEITHYIRGGEAQAGKLF MEKK4_Spur NDLQEMLQVYFEYVHSRMLMLQKLPQASVSLKNVLEEEWAFAKEMCPCIRGGEAQAGKRF AqueK228_Aque KHLQSVLQLYFSYVERLV-------QVSSTDRNLLESQWEITKDICNDISTGEIEAGLRF : . : *: *: : . ** :* : : : B0414.7_Cele CDIVESLIREVVEVYADDQIEDIKNRYVYNTDSENEDEEDDEDMITIGSPKKPLVELKAK Mekk1_Dmel CGIISKLLRSISER-LVKRTVELDQQIDG-TADTDDNEEVKWQLLTICRE---------- MAP3K4_Mmus CDIAGMLLKSTGSF-LESGLQESCAELWTSADDNGAADELRRSVIEISRA---------- MAP3K4_Hsap CDIAGMLLKSTGSF-LEFGLQESCAEFWTSADDSSASDEIRRSVIEISRA---------- MEKK4_Spur CIMASNLLHSTAEY-LEQRVDDECAHLQD---SHSGGGAIKRIITGSCRK---------- AqueK228_Aque CSMASQLIENLEVD-LKSRIDDCCDKLHEHSNNLDDPDERKHAFIELCRE---------- * : *:.. : . . . . B0414.7_Cele HRFMLELNSLTREVKERELRIFSLLRITLNDSHDAVGYELRSGVD--------------- Mekk1_Dmel ------TQSLLTVERERSIKVLFFAKTFCRDVETT-DFHREHYEHDVA------------ MAP3K4_Mmus ------LKELFHEARERASKALGFAKMLRKDLEIAAEFVLSASARELLDALKAKQYVKVQ MAP3K4_Hsap ------LKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRDLLDVLKSKQYVKVQ MEKK4_Spur ------FRELFHEVRDRAAKALGFAKMLTKDLEIASEFTLNTSLGDLMNNLKLSSHVKVK AqueK228_Aque ------FKSIIQKSRESSMKGLGFSKTLMTDLEIAAEFSITCTRE-------------VI ..: :: : : : : * . : : B0414.7_Cele --RA-QMFHEMVPDF------CLIQLTMA---------SDEQGDVNDDDDHVNLKIVLFV Mekk1_Dmel -----------------NQ----------------------------------------- MAP3K4_Mmus IPG-LENLHVFVPDSLAEEKKIILQLLNAATGKDC---------SKDP-DDVFM------ MAP3K4_Hsap IPG-LENLQMFVPDTLAEEKSIILQLLNAAAGKDC---------SKDS-DDVLI------ MEKK4_Spur MLGIFPGYQVFVPQHLHQNTPQILHLLNDLCGREDFL------STSDPSSPDAS------ AqueK228_Aque IPQ-YHACMLFVPHNIADNQQEIQKLLGVSFGHPVVEVGGPGGHSHR-HSVHYN------ B0414.7_Cele YRTSVDKAYVETCMLAISEGRKIDDGCIVIVPD--KDHKL---RKHWKGRVVKIVIDEET Mekk1_Dmel ------------------------------------------------------------ MAP3K4_Mmus ------------------------DAFLLLTKHGDRARDSEDGWGTWEARAVKIVPQVET MAP3K4_Hsap ------------------------DAYLLLTKHGDRARDSEDSWGTWEAQPVKVVPQVET MEKK4_Spur ------------------------DGYLLLVKD--EEREAE---SKWGGDTTSVNPNIET AqueK228_Aque ------------------------DSYLLFVKFSA-AGDS---IPIWTGEKINLTLSAET B0414.7_Cele RICYRWLRDDIILCLANGSIRADMEHKYKNFLKCI-------SPACSSNFLITSRIQQLT Mekk1_Dmel -----------------------------------------QHDFIC--SDVKAAFKLLQ MAP3K4_Mmus VDTLRSMQVDNLLLVVMESAHLV--LQRKAFQQSIEGLMTVRHEQTSSQPIIAKGLQQLK MAP3K4_Hsap VDTLRSMQVDNLLLVVMQSAHLT--IQRKAFQQSIEGLMTLCQEQTSSQPVIAKALQQLK MEKK4_Spur TIATSDIQVESILLVVNHSSQLT--TQRKAFQRAMGSTVTLINEQTSSHNTIAEALGELK AqueK228_Aque IVSISEMQVEGIKLVVNDSSRLE--RNQMSFLRCMGTNVEITNKRTSSHHSVAERINELK . : : * B0414.7_Cele EESLLPHLDEERKRIGILLEKTEIRL--EP--KEEQSKEKSALSSLGFKLEKHFLVAFQI Mekk1_Dmel QDVL--QV---RNKLTAIIEGVQKRCCLSNMRDLDEQDKQAVLSRTREILHQGYKFGFEY MAP3K4_Mmus NDAL--EL---CNRISDAIDRVDHMFTLEFDAEVEESESATLQQYYREAMIQGYNFGFEY MAP3K4_Hsap NDAL--EL---CNRISNAIDRVDHMFTSEFDAEVDESESVTLQQYYREAMIQGYNFGFEY MEKK4_Spur DNAL--TL---CETLVAAICQVEENLILDSMVDVEESERNNILKYSRDGMCQCFSVGFEY AqueK228_Aque LVLC--HF---GHTIIEIVERVSGNLSLE-----EISEREDLLQQYLPTMHACYNFGFE- . . : : .. . : .. . : : ..*: B0414.7_Cele HRDVAKVVSDSF-MD---------GLGNEMVEKALALTRQWMQYVEVKSTIPSPTLPMWA Mekk1_Dmel HKDVIRLFEQKI-MDQKDSGAHTVDLAL----GIIAYAKMWMHFVMERCERGRGMRPRWA MAP3K4_Mmus HKEVVRLMSGEF-RQ---------KIGD----KYISFAQKWMNYVLTKCESGRGTRPRWA MAP3K4_Hsap HKEVVRLMSGEF-RQ---------KIGD----KYISFARKWMNYVLTKCESGRGTRPRWA MEKK4_Spur HKEVSRLLSNK---R---------GLGE----SILKLAQQWMNFALNKWERGKGRRPRWA AqueK228_Aque --DLSRLFGDEYIHQ---------KLGA----EMLHFSQQWIVFATTKCIRGHGKQPRWA :: ::. . :. : :: *: :. : * ** B0414.7_Cele SPGFTFLQYITEPRWSNPEIMTNDQFQEFNDLVKLFEAKVIKSSSN-------------- Mekk1_Dmel SQGLEFLILACDPQIT--QHLDDDEFEALKQQMDRCISHVIGITSEPEK---VAKKKASP MAP3K4_Mmus TQGFDFLQ-AIEPAFI--SALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYLAIHRNSP MAP3K4_Hsap TQGFDFLQ-AIEPAFI--SALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYLAIHRNSP MEKK4_Spur NQGLEFLILACEPRNV--AHLIEEEFQDLQRLMKQCIEHVIGKTTP-QSPD--------- AqueK228_Aque VLGLEFILLSCSPRML--STISPSRYENVKKQMERCLDHVIGEVP--------------- *: *: .* : . : .: :. :** B0414.7_Cele ----------------IGTPGNTGTPMQR-NTRSTSSK---------------------- Mekk1_Dmel RT-------------------------RKTSSPATSRSRTPTRTPMSAGM-VL------- MAP3K4_Mmus RPVKVPRCHSDPPNPHLIIPTPEGFSTRSVPSDARTHGNSVAAAAAVAAAATTAAGRPGP MAP3K4_Hsap RPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAA-AA-AAAAAAVAASRPSP MEKK4_Spur ---------------RMGSPDFLGGKM--MRSRSSKSIRSSSSS---------------- AqueK228_Aque ------LLSSNTFSEAYTSPQYIGGWTRQ-KSRMKKSGNSLSRTPVIEERDE-------- : . B0414.7_Cele ----------------T------------------------------------------- Mekk1_Dmel -----N--------PNTPPLQSPPY-NKLLHPQFSLKEDV-SGTSYSPVDSSDYVDTPC- MAP3K4_Mmus GGGDSVPAKPVNTAPDTRGSSVPEN-DRLASIAAELQFRSL-SRHSSPTEERDEPAYPRS MAP3K4_Hsap SGGDSVLPKSISSAHDTRGSSVPEN-DRLASIAAELQFRSL-SRHSSPTEERDEPAYPRG MEKK4_Spur ---------------DQ-SITSPTSMGDLRRIPSVERFLSITSSNTSPTEDRLDPGFPRY AqueK228_Aque ----------FDAGADSSGIDSPVLSGD-ISFAASEPLYSL-P--KSPPTTMLIPKMDRG B0414.7_Cele -----SSSSME-N-------------------------------HKRTRKENQMLKLQEL Mekk1_Dmel ----QRS-------ANGELRLLVPQTPPTPASPGKSSLESTPLA---LRQERVRDAVNRL MAP3K4_Mmus DSSGSTR-------RSWELRTLISQTKDSAS--------------KQGPIEAIQKSVRLF MAP3K4_Hsap DSSGSTR-------RSWELRTLISQSKDTAS--------------KLGPIEAIQKSVRLF MEKK4_Spur DKRASPNPGCSSPMPSNHVFRAVSRDPDYAPRGANNGTPTGPAGQRRDRRSHKVQALERL AqueK228_Aque DSVAVYSSPLS-HTPSQEV--------------------PPPVNQRQIKFKTIEEECKRI . . : B0414.7_Cele EDKRNRIDYDNLQIGKVITDDNR--RNFVLATDKKITTKAPFQWALLDHIASGSFGS-VH Mekk1_Dmel DMDLEDGLRERRLIGQVKSLNS---SDK-VHIR---ARSVHFRWHRGIKIGQGRFGK-VY MAP3K4_Mmus EERRYREMRRKNIIGQVCDTPKS--YDNVMHVG---LRKVTFKWQRGNKIGEGQYGK-VY MAP3K4_Hsap EEKRYREMRRKNIIGQVCDTPKS--YDNVMHVG---LRKVTFKWQRGNKIGEGQYGK-VY MEKK4_Spur EQARNDKLQRESMIGRISDQHTS--H-EVVNIN---CKKVTFRWQRGFKIGEGQFGTTVY AqueK228_Aque DKVRDDELRVKRIIGRVTERSGASVFELSRLTD---LKQSHFTWRRGRKLGEGQFGV-VY : . **:: . * * ::..* :* *: B0414.7_Cele RAMDIDSHRVIAAKVMRIQRENHKAIE---SEINIFRQLIHENLVKYYGVQVEDSDV--- Mekk1_Dmel TAVNNNTGELMAMKEIAIQPGETRALKNVAEELKILEGIKHKNLVRYYGIEVHREEL--- MAP3K4_Mmus TCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEM--- MAP3K4_Hsap TCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEM--- MEKK4_Spur SCINMNTGETLAVKEMRFQRNDHQVIRDIADEIKNLEGIRHPNLVRYYGVEIHRVRYPHS AqueK228_Aque ECINLDRGEVQAVKMISLKEKSHNTVRDILSEVGVFQSINHKNIVHFHGVEIHDTDL--- .:. : . * * : :: . ..:. .*: :. : * *:*::.*:::. B0414.7_Cele -IIFMEYCSQ--GTLERICHG--KMDLKMVRQYTNSLLRAVQYLHSHKIIHRDIKPANIF Mekk1_Dmel -LIFMELCSE--GTLESLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIF MAP3K4_Mmus -YIFMEYCDE--GTLEEVSRL--GLQEHVIRLYTKQITVAINVLHEHGIVHRDIKGANIF MAP3K4_Hsap -YIFMEYCDE--GTLEEVSRL--GLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIF MEKK4_Spur VIGVLNHHSETRTTLKFVCHL--E--------------------HEISLIIKNMNDL--- AqueK228_Aque -YLFMEYCNQ--GTLWGAAKQ--GLEERMIRLYTRDLLRAVDVLHDRGIVHRDIKGANIF .:: .: ** . *. :: :::: B0414.7_Cele LDK-CTVLKLGDFGCSSRLVE-SSTVYGEFQTTAG---TPQFMAPEIYSYGEKDETTGSY Mekk1_Dmel LVDGSNSLKLGDFGSAVKIQA-HTTVPGELQGYVG---TQAYMAPEVFTKTN-------S MAP3K4_Mmus LTS-SGLIKLGDFGCSVKLKNNAQTMPGEVNSTLG---TAAYMAPEVITRAK-------G MAP3K4_Hsap LTS-SGLIKLGDFGCSVKLKNNAQTMPGEVNSTLG---TAAYMAPEVITRAK-------G MEKK4_Spur ---------------------NQHFMPYKIYSKMLSAYHNSYMAPEVINQTGK-----DK AqueK228_Aque LSD-D-SVKLGDFGLSVQLHNVNKTAPQEIKHQRG---TIPYMSPEVVLMQ--------- :. :*:**: B0414.7_Cele SGYGRSVDIWALGATVVNMMTGKVPFEG-QTR-HQIAFALCFRKQKPTYP-DIADKRPDV Mekk1_Dmel DGHGRAADIWSVGCVVVEMASGKRPWAQFDSN-FQIMFKVG-MGEKPQAP-ES--LSQEG MAP3K4_Mmus EGHGRAADIWSLGCVVIEMVTGKRPWHEYEHN-FQIMYKVG-MGHKPPIP-ER--LSPEG MAP3K4_Hsap EGHGRAADIWSLGCVVIEMVTGKRPWHEYEHN-FQIMYKVG-MGHKPPIP-ER--LSPEG MEKK4_Spur PGYGRQADIWSLGCVVIEMVTGKRPWHDYDHE-FTIMYKVG-EGAVPHIP-DA--MNPEG AqueK228_Aque -DMGRPMDIWAVGCVVVEMFTSKRPWIELEDNAMAIMFQLG-NKKSPSYPAEK--MNDEM . ** ***::*..*::* :.* *: : . * : : * * : : B0414.7_Cele KRFFDNCFEFLPNDRPTAAELLQTTFANVNITDENHIPDYQSQSSKDKSSPSSFFLV Mekk1_Dmel HDFIDHCLQHDPKRRLTAVELLEHNFCKYGR-DECSSEQLQMQVRGSFRRNVATSSS MAP3K4_Mmus KAFLSHCLESDPKIRWTASQLLDHAFVKVCT-----------------------DEE MAP3K4_Hsap KDFLSHCLESDPKMRWTASQLLDHSFVKVCT-----------------------DEE MEKK4_Spur KEFLSNCLKHDCTKRWTANKLLDHPFLKVK-------------------------YV AqueK228_Aque IDFLDLCFETDPKQRAVASKLLSHSFVKVMD--S------------------CDDNS *:. *:: . * .* :**. * :