CLUSTAL W (1.83) multiple sequence alignment MELK_Hsap MK-----------DYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGS MELK_Mmus MK-----------DYDELLKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGS W03G1.6_Cele MS-----------KYEVLQGFYAVHDELGSGGFGKVRLATHLLTNQKVAIKIIDKKQLGH MELK_Spur ------------------------------GGFAKVKLATHLLSGQKVAIKIMDKHALGD AqueK065_Aque MSHHHHHRQHVRPRYPEVEENYELFETLGSGGFAKVKLGKHKLTGEK------------D ***.**:*. * *:.: MELK_Hsap DLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEET MELK_Mmus DLPRVKTEIDALKSLRHQHICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEET W03G1.6_Cele DLPRVQTEMDALRNLSHQNICRLYHYIETEDKFFIVMEYCSGGEMFDYIVRKERLEESEA MELK_Spur DLPRVKTEIKAMKELVHQHICTLYEVVETKNKIFMVIEFCPGGELFDYIVAKDRLKEAEA AqueK065_Aque DLPRVYREMRALKNLHHQHVCQLFEVIETDLMIYMILEYCSGGELFDYIVAKEKLKEPEA ****: *: *::.* **::* *:. :** :::::*:*.***:****: :::*.* *: MELK_Hsap RVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKP-KGNKD------ MELK_Mmus RVVFRQILSAVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKP-KGNKD------ W03G1.6_Cele RHFFRQLVSAIAFVHSQGYAHRDLKPENLLLTEDLHLKLIDFGLCAKTEKGRIDK----- MELK_Spur RGFFRQIIAAVAFIHNEGYAHRDLKPENLLLDEDQSLKLIDFGLAAKP-KGNKDHLETCC AqueK065_Aque RTFFRQIVAALKYVHTSGFIHRDLKPENLLLDEYSNIKLIDFGLVAEP-KDIR-H----- * .***:::*: ::*..*: **********: * :******* *:. *. MELK_Hsap ------------------------YHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGIL MELK_Mmus ------------------------YHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGIL W03G1.6_Cele ------------------------HNLDTCCGSPAYAAPELIQGLQYKGNEADVWSMGIL MELK_Spur GSPAYAAPELVSGKEYIGSEGGMKDHLETCCGSPAYAAPELVSGKEYIGSEADIWSMGVL AqueK065_Aque -------------------------LLKTCCGSPAYAAPELIKGGPYIGPRADVWSLGVL *.***** *******:.* * * .**:**:*:* MELK_Hsap LYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLL MELK_Mmus LYVLMCGFLPFDDDNVMALYKKIMRGKYEVPKWLSPSSILLLQQMLQVDPKKRISMRNLL W03G1.6_Cele LYTLLVGALPFEDDNMQIMYKKIQSGCFYEPEFLSPLSKQLLRAMLQVVPERRISVKKLL MELK_Spur LYALLCGFLPFDDDNVSLLYRKILSGVYEEPPWLSVETKELLRHMLQVNPTKRIKMKELI AqueK065_Aque LYALLNGFLPFDDDNTAELYRLIQNGRYDKPRWLSRDSLEILDVLLQTIPERRVTVDELL **.*: * ***:*** :*: * * : * :** : :* :**. * :*:.: :*: MELK_Hsap NHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRN-NRQTMEDLISLWQYDHLTATY MELK_Mmus NHPWVMQDYSCPVEWQSKTPLTHLDEDCVTELSVHHRS-SRQTMEDLISSWQYDHLTATY W03G1.6_Cele EHDWLNHKYTQPVKWNTIYDKNFIDRDVARVMSKYYGFESTDKMIEKIKEWNFDYMTSTY MELK_Spur IHPWVVQAFGSPVDWESKCEKNQLNLDCITEMAMHYGK-SKKDITSTLKQWKYDHMTATY AqueK065_Aque NHPWVMQGYSRPIVWDSKIDINELDTDCIEELSRYHGV-STTAMTERVLRWDYDHLTATY * *: : : *: *:: :: * :: :: . : . : *.:*::*:** MELK_Hsap LLLLAKKARGKPVRLRLSSFSCGQASAT---------------------------PFTD- MELK_Mmus LLLLAKKARGKPARLQLLSFSCGTASTT---------------------------P---- W03G1.6_Cele YALLHRKRNGMEIILPMVRNSTNTAPPN--------------------VQNILCSPTIH- MELK_Spur FILLAAKYRGKTVRLPMANRPLTEKNQT-DSAMRFHHHHHQHHNP-HNHHDNLEPPTSSP AqueK065_Aque FLLFRQKLAGKEPKIKAPPKKVVTRAPSLNEKG--------PSSPLTSHRPYLNKPSSLA *: * * : . * MELK_Hsap -IKSNNWSLEDVTASDKNYVAG----LIDYDWC-------EDDLS-TGAATPRTSQFTKY MELK_Mmus --KSKNLSLEDMSTSDDNCVAG----LIDYELC-------EDKL-----LAPKTPQVTKH W03G1.6_Cele -A-SLENNLDKSGLEDDDSDPSSISSSSDISARLKKNCVVSDESSSSRFVKPMSPAAEKD MELK_Spur Y---MFSSMED-GLEDE------------------------ESY-----IITSSPHR-RT AqueK065_Aque YDKTKNEKEDDNSISDDDKEEDSESE-----SD-------EDKP-----IVTKDIEV-KV . :. .*. :. . : MELK_Hsap W-----------------------TES-------NGVES-K---SL-TPALCRTPANKLK MELK_Mmus L-----------------------AES-------NHAAS-K---SP-APGVRRAVANKLM W03G1.6_Cele KKMSYVNAMLTMPSQFTGRSPLRIPESPMSVRSSDSASL-G---SAATPSR-GGV--KDN MELK_Spur A-----------------------SER-------RHSGDRRRPRSSQNPRD-RPVS---T AqueK065_Aque Q-----------------------PPS-------NTSI-TSS------PRT-RKIS---L . * MELK_Hsap NKENVYTPKSAVKNEEYFMFPEPKTPVNK-NQHKREILTTPNRYT--TP----------- MELK_Mmus DKENVCTPKSSVKNEEQFVFSEPKIPVSK-NQYKREIPASPTRFP--TP----------- W03G1.6_Cele DKENASTGKNYRMGASTCKSRG---PLKITGVGKAENVTIKTQYL--TL----------- MELK_Spur NLDGTYVKPGDLLGEDTYMVHTPLVSGKE-NHRDNEGFVKPVGLPLKTPVRRRSKSDAKE AqueK065_Aque GQ---PMHPPTL-GE-IVSLRRPAE-------------SPKIGRPVYPAINHILASEAVE . . . MELK_Hsap ---SKARNQCLK--------ETPIKIPVNSTGTDK-----------LMTGVISPER---- MELK_Mmus ---AKARAQCLR--------EAPVRTPGNSAGADT-----------LTTGVISPER---- W03G1.6_Cele ---KISRNENYK--------EGTMKSVYTTPNTRP-----------TLRGLFSPGNAEHK MELK_Spur KASQKARGAALKQPVVPTLSLPPVVTPSRSMDGDL-NRLSV--NSARSTGAFDI------ AqueK065_Aque GENEGSFPVQVKQKEPKTLTLPPILSPPGSIAPSASFQGGIPGYAPFLTPQLQPK----V : : .: : :. MELK_Hsap -R--CRSVE-----------LDLNQAH---MEE--TPK---------RKGAKVFGSLERG MELK_Mmus -R--CRSMD-----------VDLNQAH---MED--TPK---------KKGTNVFGSLERG W03G1.6_Cele KRQRARSSDRASIGMPPGSPVSIGSAHSANNADGRTPR---SRIKTNRLPQRVFTSLERK MELK_Spur QK--AVSME-----------DSLDRVM---MED--GDI---KRHGISGSAKKIFGSFEKG AqueK065_Aque VK--TMSYD-----------SRLNKAG---GDS--SEELSLPPLPHSPKSRRRFGSVDFV : * : :. . . . * *.: MELK_Hsap LDKVITVLTRSKRKGSARD-GPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDF-VQ MELK_Mmus LDKVLTALTRNKKKGSARD-GPRKRKLHYNVTTTRLVNPDQLLSEIMAILPKKNVDF-VQ W03G1.6_Cele KEKLITLLTPRKMQRDSPQ-VLKDVKNMVNVSMTASQDPEEVRNLLKKVFDDERMRY-EL MELK_Spur IDKMIDLLSPRRRSTAGID-EPRKVKALYNVSTTSTLPADIVVERLKEGLMYSDIDSYKQ AqueK065_Aque LTKLRKAVRRPSSGGENGDLGPRTVKGLFDANTTSCKSESEVMQEIERVLNDMNIPFTKK *: : : : * :.. * . : . : : : MELK_Hsap KGYTLKCQTQSDF---GKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSS MELK_Mmus KGYTLKCQTQSDF---GKVTMQFELEVCQLQRPDVVGIRRQRLKGDAWVYKRLVEDILSG W03G1.6_Cele NGWKFLATQETVH---GW--MTVELEIVRLQMFDKVGIRRKRLKGDAFMYKKVCEKILQM MELK_Spur KGYTLRCKKQDSK---GKTVLSFDMEVCRLPQMEMVGIRRKRLKGDTWEYKRMCQTILEH AqueK065_Aque NNYTYICKLEPQMKRGSKKPLTFSLEVCLIGNLSMMGIKRKRIGGDVWRYKEICKQILDS :.:. . : . : ..:*: : . :**:*:*: **.: **.: : **. MELK_Hsap CK-V MELK_Mmus CK-M W03G1.6_Cele AKIE MELK_Spur SR-L AqueK065_Aque TH-L :