CLUSTAL W (1.83) multiple sequence alignment MHCK-A_Ddis MFNIKKRKESITGIPPINVNSPQSVPLSGTLQSPLITPNSPNFVSRQCPFKKFGCSSFLV MHCK-B_Ddis MIFK-------------------------------------------------------- MHCK-C_Ddis MEEK-------------------------------------------------------- MHCK-D_Ddis MEDN-------------------------------------------------------- * MHCK-A_Ddis SKAEFDNHLKDDAQFHLQLAVEKFDHQFDLHTQLMAHFTEQMEDQLEKTMKVVRNHTDSL MHCK-B_Ddis ------------VWF-------------------------SYEDEEVELSELTN---DTT MHCK-C_Ddis ------------KT---------------------------------------------- MHCK-D_Ddis ------------SFLKLSKKIEKILEKNDYLKKKVEQLTKSVDNHEFKIQEL-------- MHCK-A_Ddis GGNVQTKLDEGIEKCMAFAKKVEQQQQQLAKRLITQQIQEKKSTSSPLVKG------GIS MHCK-B_Ddis VSAIRKILHEG--KIFRFPYGTSQTDLQIGKMLP-------------------------- MHCK-C_Ddis ------------------------------------------------------------ MHCK-D_Ddis -----------------------------LLLLRKNNIHPTTTTTTTTTTNNNSTCVGIS MHCK-A_Ddis GGG---GSGGDDSFDGANISSMSTSKQELQQELQSLSIKMKKELTELSDELSQKLERSTG MHCK-B_Ddis ------------------------------------------------------------ MHCK-C_Ddis ------------------------------------------------------------ MHCK-D_Ddis NSPPLSPRTSTDSMTNSNNSSATSSTTPSPT----------------------------- MHCK-A_Ddis NIDIKIKRIEGEVNEKIDKRQLVSTIDDSIGKKTDSIGYTLESSIIKKVEEKEKKKSEQN MHCK-B_Ddis ------------------------------------------------------------ MHCK-C_Ddis ------------------------------------------------------------ MHCK-D_Ddis ------------------------------------------------------------ MHCK-A_Ddis QLLFDSKIESLKDKIKIIETQQLDTSSEVRKLKLESTSSGNLMAGLN------------- MHCK-B_Ddis ------------------------------------------------------------ MHCK-C_Ddis ------------------------------------------------------------ MHCK-D_Ddis ------------QTSTITTTSQIDPNSL--------TNSNNSFIPINSPISQTTVNNNNN MHCK-A_Ddis ----------------GTSGRPSSSSHFIPSSVSAAANNINKNEIMEEVKKVEEKLQKKI MHCK-B_Ddis ------------------------------SGSGGGA----------------------- MHCK-C_Ddis ---------------------------------GAAA----------------------- MHCK-D_Ddis NNNNNNNNNNNNNNNNNNNNNNNLNNQTITSPLSTSSSNSNSNSN--------------- . .: MHCK-A_Ddis REEIDNTKSELSKVERSVKDNRSEIEGLE----KDCKNQFDKQDNKIKQVEDDLKKSDSL MHCK-B_Ddis ----------------------------------TADSKFEKFKARNTLADIQYKVGDTL MHCK-C_Ddis ----------------------------------ALALLNQK------------------ MHCK-D_Ddis --SSSPIVSPVSSPQLSGSGNRPRIQFLGNGRMPSTGNLFKKEDSSDSLLKYS-KDSEHL .* MHCK-A_Ddis LLLMQNNLKKYNEFVDRERDRESERLKLQDSIKRLEQNQKKIEAEIQEGNEQVERVLREE MHCK-B_Ddis YVRV--------------------------KKSKP------------------------- MHCK-C_Ddis ----------------------------------------FPVADV-------------- MHCK-D_Ddis YIVP--------------------------TTPRPS---KSPSMDFIAST-S-------- MHCK-A_Ddis ASISPISSVPKSPITTKRSSIILNSPPMT----SQQSSPKIQDLLSS-SGSSSVSGINIS MHCK-B_Ddis ------------------------------------------------TNDSLLPTLNIA MHCK-C_Ddis ----------------------------------------------------------I- MHCK-D_Ddis -LINTVSSNNT-DSTNNDNSSILNDQQNQQQNQQQQNQQQQQEEINFITTEDKLP--NLP : MHCK-A_Ddis -SETGEMGILWEFDPI---INKWIRLSMKLKVERKPFAEGALREAYHTVSLGVGTDENY- MHCK-B_Ddis FLDGSERAIKWEYDPYT-TTAQWTCTATLVKVEPVPFAEGAFRKAYHTLDLSKS------ MHCK-C_Ddis AGTKCERAIKWELTIGDDLKPKWTHSIVCVSIEKTPFAKGSCRTAHKLKDWSQP-DQ--- MHCK-D_Ddis -DSNCQWAIIWEYSAN---DDEWTKALIIVEIDAKPFAKGALRNAYQLKIRSNA-MQCFN : .* ** :* :.:: ***:*: * *:: . MHCK-A_Ddis ----------PLGTTTKLFPPIEMISPISKNNEAMTQLKNGTKFVLKLYKKEAEQQASRE MHCK-B_Ddis ----------------------------------------G--ASGRYVSKIGKKPTPRP MHCK-C_Ddis ------------------------------------------GLVGKFS---TNKKTTRD MHCK-D_Ddis HFATPIHEKYMEGKKLN-------LSQIPKL-------NQNLSLDTLYVAKDSKTSVNFN : . MHCK-A_Ddis LYFEDVKMQMVCRDWGNKFNQKKPPKKIEFLMSWVVELIDRS--------PSSNGQPILC MHCK-B_Ddis SYFEDVKMQMIAKKWADKYNSFKPPKKIEFLQSCVLEFVDRT--------SS----DLIC MHCK-C_Ddis SYFTDVLMQTFCAKWAEKFNEAKPPKPITFLPSYVYELIDHP--------PP----YPVC MHCK-D_Ddis RYFEDVKMQMVCKSYGERYNSNHPPKKIEFLSAWVIEIQGTTNYRVGNRNSSN---NTLY ** ** ** .. .:.:::*. :*** * ** : * *: . . .. : MHCK-A_Ddis SIEPLLVGEFKKNNSNYGAVLT-NRSTPQAFSHFTYELSNKQMIVVDIQGVDDLYTDPQI MHCK-B_Ddis GAEPYVEGQYRKYNNNSGFVSNDERNTPQSFSHFTYEHSNHQLLIIDIQGVGDHYTDPQI MHCK-C_Ddis GGEPFIEGDYKKHNNNSGYVSSDARNTPQSFSHFSYELSNHELLIVDIQGVNDFYTDPQI MHCK-D_Ddis GLELFMKGEFKKQNSNFGTVFT-ERNTPQSFSHFTYECTTHEMVVVDIQGVDDIYTDPQV . * : *:::* *.* * * . *.***:****:** :.::::::*****.* *****: MHCK-A_Ddis HTPDGKGFGLGNLGKAGINKFITTHKCNAVCALLDLDVKLGGVLSGNNKKQLQQGTMVMP MHCK-B_Ddis HTYDGVGFGIGNLGQKGFEKFLDTHKCNAICQYLNLQSI------NPKSEKSDCGTVPRP MHCK-C_Ddis HTKSGEGFGEGNLGETGFHKFLQTHKCNPVCDFLKLKPI------NQSKKALLRGTLPVV MHCK-D_Ddis HTKDGKGYGEGNLGQKGIEKFLISHKCSPICLQFGLPPI--GLETGRNAHRVIRGTMLLP ** .* *:* ****: *:.**: :***..:* : * . . . **: MHCK-A_Ddis DIL--------------------------------------------------------- MHCK-B_Ddis DLI--------------------------------------------------------- MHCK-C_Ddis QLMDFHDAIGLNGNGSGPKNNYDMNYFRNGGGAQQPISLDDEEKMLQEQLERIRAQQQQK MHCK-D_Ddis DLT--------------------------------------------------------- :: MHCK-A_Ddis ------------------------------PELM-------------------------P MHCK-B_Ddis -----------------------------FPDTS-------------------------E MHCK-C_Ddis SKPSPPLVKQPSGNNLHKQQSPSSPTSKPVPQIVKTPSQSNVVNKSPVSPPKENSNVKLE MHCK-D_Ddis ------------------------------PDLY-------------------------E *: MHCK-A_Ddis SDNTIKV----------------------------------------------------- MHCK-B_Ddis RDNNNNNNNN------------NNNNNNNNNNNSNNNNNNNSSISKSLVEISSGSKER-- MHCK-C_Ddis QDNINNNNSSISSNNDNSNNNNNNNDNINNSSNSSSVNSNSSSVSSSSSSSSSSSSSSTT MHCK-D_Ddis PEYP-------------------------------------------------------- : MHCK-A_Ddis ----------------------------------------------GAK--QLP-----K MHCK-B_Ddis --------NDRDSPSRQLFVSNDG------NTLNTN--KERSKS--KSIDLEKPEILINN MHCK-C_Ddis NAAPISIQVSRNSPPPQQPIQPSSAAASASSTSSSNVPTPESTSTSSME--QTP----DR MHCK-D_Ddis --------------------------------------------------------LIEN . MHCK-A_Ddis AEFSK--KDLKCVSTIQSFRE--RVNSIAFFDNQKLLCAGYGDGTYRVFDVN-----DNW MHCK-B_Ddis KKKES--INLETIKLIETIKGYHVTSHLCICDN--LLFTGCSDNSIRVYDYKS----QNM MHCK-C_Ddis SEFEK--WDLTSIKNIDTVRG--LQSE-CITGDSLRLYSGSNDGQIGVWDAVE------L MHCK-D_Ddis QPSNPLNSELTSIVHLSGHDE--RVCSLLINQDKTKLYSASADGYVKIWNLTNNEDLSKI . :* : :. : : * :. *. ::: MHCK-A_Ddis KCLYTVNGHRKSIESIACN---SNYIFTSSPDNTIKVHIIRSGN---------------- MHCK-B_Ddis ECVQTLKGHEGPVESICYN---DQYLFSGSSDHSIKVWDLKK------------------ MHCK-C_Ddis KHVTNIKAHGKSIRAVIKRPGFDQNILTAGADSLVKEWDINT------------------ MHCK-D_Ddis QMIDSFRAHRRSIEKMLLN---EKYLFTASSDGTIKIWSLPTTTTTTTTSKQSSSSSSSS : : ....* .:. : . .: :::...* :* : . MHCK-A_Ddis TKCIETLVGHTGEVN--CVVANEKYLFSCSYDKTIKVWDLSTFKEIKSFEGVHTKYIKTL MHCK-B_Ddis LRCIFTLEGHDKPVH--TVLLNDKYLFSGSSDKTIKVWDLKTLECKYTLES-HARAVKTL MHCK-C_Ddis QQTIKEI-KESNEVN--TIFIQDNLLYTGCNDKTVKVWDMRSYECVKTLSG-HTRAIKSV MHCK-D_Ddis YECIGKLEDHTAEVNDMCIDIENNFLVSCSFDKQIKIYDLSTFKCIKSLNA-HGKSIKSI . * : . *: : ::: * : . ** :*::*: : : ::.. * : :*:: MHCK-A_Ddis ALSGRYLFSGGNDQIIYVWDTETLSMLFNMQ-GHEDWVLSLHCTASYLFSTSKDNVIKIW MHCK-B_Ddis CISGQYLFSGSNDKTIKVWDLKTFRCNYTLK-GHTKWVTTICILGTNLYSGSYDKTIRVW MHCK-C_Ddis CAMGNLLFSGSNDQQIYVWNLATGTILTNFQ-GHEGWVKTLYAHNNMLYSGSHDETIRIW MHCK-D_Ddis YMSGKYLFSSSNDQSIKIWDLEMCMCVYGMNDAHDAPITSLRMFGNRLFSASKDGEIKDW *. ***..**: * :*: :: .* : :: . *:* * * *: * MHCK-A_Ddis DLSNFSCIDTLKGHWNSVSSCVV-KDRYLYSGSEDNSIKVWDLDT----LECVYTIPKSH MHCK-B_Ddis NLKSLECSATLRGHDRWVEHMVI-CDKLLFTASDDNTIKIWDLET----LRCNTTL-EGH MHCK-C_Ddis DLKTTRCVNTIKCKDR-VETLHV-TNQGIFAGSGDW-LQVFSHDK----YENLASLN--T MHCK-D_Ddis NLSTFQPTTTLDQHNMAITDILVTSNGYLFVSSDDSTIRIIDISNQNEPIKIISS-TKAH :*.. *: : : : : :: .* * ::: . .. . : MHCK-A_Ddis SLGVKCLMV--FNNQIISAAFDGSIKVWEWQSK MHCK-B_Ddis NATVQCLAVWEDKKCVISCSHDQSIRVWGW--N MHCK-C_Ddis RSSILCLWR--NQNQLFTGSLASNLKVWSWDKM MHCK-D_Ddis RSGVNSLAT--DGKRIFSGGCDNLIKVWNWKNK : .* : ::: . ::** *