CLUSTAL W (1.83) multiple sequence alignment MAPKAPK5_Hsap MSEE-------------------------------------------------------- MAPKAPK5_Mmus MSED-------------------------------------------------------- MAPKAPK5b_Spur MSLFTPITNLRLGGSTPIAPDNQAVYITEVDAQKRFARCGEPLIAMVCSDHTIKLVGKET AqueK074_Aque MRRVSGA----------------------------------------------------- * MAPKAPK5_Hsap ------------------------------------------------------------ MAPKAPK5_Mmus ------------------------------------------------------------ MAPKAPK5b_Spur MSSAGQLKGHGGPVSGVKFAHRNPFTVFSSSRDGTVRCWDTRMKRNKAPQVFTGYEGNSF AqueK074_Aque ----------------IDFVYKLPFWSYSRLQ----RREEALLTLPVASLLFGSITGNLI MAPKAPK5_Hsap ---------------SDMDKAIKETSILEEYSINWTQ----------------------- MAPKAPK5_Mmus ---------------SDMEKAIKETSILEEYSINWTQ----------------------- MAPKAPK5b_Spur TSFD-------INSTDDILSAGTEAVDNDAYLMFWDRRSTNLLGTYKESHSDDITQVKFH AqueK074_Aque NRKRSKPQNLSLMSKYERDPEFKKTSILDDYEIKWNR----------------------- : .:: : * : * : MAPKAPK5_Hsap -----KLGAGI-SGPVRVCVKKSTQERFALKILLDRP---KARNEV------RLHMMCAT MAPKAPK5_Mmus -----KLGAGI-SGPVRVCVKKSTQERFALKILLDRP---KARNEV------RLHMMCAT MAPKAPK5b_Spur PTKSSSLATGSTDGLVCVFDTSQTNEEDALVTTLNSE---SSVSHIDWCGTNSEYLYCLT AqueK074_Aque -----SLGTGV-SGPVRLCIHRATGKEYALKLLLDRSDRKKAEIEA------TLHWRCSG .*.:* .* * : * :. ** *: .: . : * MAPKAPK5_Hsap HPNIVQIIEVFANSVQFPHESSPRA---------------------RLLIVMEMMEGGEL MAPKAPK5_Mmus HPNIVQIIEVFANSVQFPHESSPRA---------------------RLLIVMEMMEGGEL MAPKAPK5b_Spur HTETIRIFDAVESSEITK-FDSVRESLKEDRCKVDYLVDCFYHSGLKSLVVLGGTVGGDL AqueK074_Aque GDHIVRIVDIYRNEIQQPGELSPKK---------------------RILLVMELMEGKEL . ::*.: .. * : : *:*: * :* MAPKAPK5_Hsap FH-RI-SQHRHFTEKQASQVTKQATLALRHCHLLNIAHRDLKPENLLFK----------- MAPKAPK5_Mmus FH-RI-SQHRHFTEKQASQVTKQIALALQHCHLLNIAHRDLKPENLLFK----------- MAPKAPK5b_Spur HLLTVGKDRLHFVHS----------LKGTHKGVVRCLHWDNQTETLVTGGEDSIVSAWQP AqueK074_Aque FD-YI-SKRHHFTEHEASKYILQIVRGVQFCHRLNIAHRDIKPENLLLLKPA-------- . : ..: **.. . :. * * :.*.*: MAPKAPK5_Hsap -DNS-LDAPVKLCDFGFAKIDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTP MAPKAPK5_Mmus -DNS-LDAPVKLCDFGFAKVDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTP MAPKAPK5b_Spur DRNANQSSSKKGSPAQTSRIRQGRRAEKRGSPV----KVLEAQKRQRREQKNLIQTSPRP AqueK074_Aque -SNP-EDVVIKLSDFGFAKVDNGDLKTPQFTPYYVAPQVLEAQKRQKESLSGYK--HRTP *. . * . ::: :* : :* :*****:*::.. .. * MAPKAPK5_Hsap YTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISE MAPKAPK5_Mmus YTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRKKIMTGSFEFPEEEWSQISE MAPKAPK5b_Spur YTYDKGCDMWSLGVIIYIMLCGYPPFYPDTPSRQLSKDMRHKIMAGQYEFPTEEWSLISD AqueK074_Aque YYYDKSCDIWSIGVIMYIMLCGYPPFYSEVPHQALSNRMKQKIMSADFDFPENDWKAVTD * *:*.**:**:***:*:*********.. : :.: *::***:..::** ::*. ::: MAPKAPK5_Hsap MAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAE MAPKAPK5_Mmus MAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAE MAPKAPK5b_Spur EAKDVVKRLLRVDPTERLTIEELCSHPWLRENSAPNTELHSPAIMLDKNMLDDAKQIHSE AqueK074_Aque EAKDLIRKMLCVEPSERLSIEEVLHHPWLAQNASPNRDLNSPYLISDKDALVEVQGAHAK ***:::::* *.* ***:** : **** .. : : * *. :: ** : : *:: MAPKAPK5_Hsap QLANMRIQDLKVSLKPLHSVNNPILRKRKLLGTKPKDS-VYIHDHENG--AEDSNVALEK MAPKAPK5_Mmus QLANMRIQDLKVSLKPLHSVNNPILRKRKLLGTKPKDG-IYIHDHENG--TEDSNVALEK MAPKAPK5b_Spur QLTAMRIPDKKVMLKPVAKANNPIVRKRILTRGQSIDN-KIGEEQPPKKQNRENSEGVTC AqueK074_Aque LLQNFRRDDTGFYLKPLGQAKNPVLASRMKKQEEKKESGGAGNESEP-----SSSKAVQS * :* * . ***: ..:**:: .* : :. .: ... .: MAPKAPK5_Hsap LRDVIAQCILPQAGKGENE-----DEKLNEVMQEAWKYNRECKLLRDTLQSFSWNGRGFT MAPKAPK5_Mmus LRDVIAQCILPQAGKGENE-----DEKLNEVMQEAWKYNRECKLLRDALQSFSWNGRGFT MAPKAPK5b_Spur LRNIIAHCIVPP--KDANG-----EDALCELMKRACQYNRDCPSLDKALNNLSWNGEQFC AqueK074_Aque LKSLMDVCNMPPPPPSLSSESSLSSSFLSESVKNALVLNEHNASLLKALEQESWNGNEFI *:.:: * :* . . .. * * ::.* *.. * .:*:. ****. * MAPKAPK5_Hsap DKVDRLKLAEIVKQVIEEQTTSHESQ MAPKAPK5_Mmus DKVDRLKLAEVVKQVIEEQTLPHEPQ MAPKAPK5b_Spur DKVDRSELALLLKDIVDQK-ERHEKC AqueK074_Aque HQVNCKRLASSLQELIEQL-E----P .:*: .** :::::::