CLUSTAL W (1.83) multiple sequence alignment MNK2_Hsap MVQKKPAELQ---------------------------------------------GFHRS MNK1_Hsap MVSSQKLE---------------------------------------------------- Lk6_Dmel MVEPKSGTAA---------------------------------------------SAAA- MNK2_Mmus MVQKRTAELQ---------------------------------------------GFHRS MNK1_Mmus ------------------------------------------------------------ R166.5_Cele MTILHAGYPQ---------------------------------------------SPVVH Mnk_Spur MGNDRGKQAI---------------------------------------------VYKK- AqueK075_Aque MEGTASRAASTKMEDREEIRDLLQFKHDFTLGLVSENGSSKTNGSIDGKMGAAEKRNDES MNK2_Hsap FKGQNP--------------------------------FELAFSLDQ-PDHGDSDF-GLQ MNK1_Hsap ----KP------------------------------------------------------ Lk6_Dmel AKASNN---------------------------------------------------NNN MNK2_Mmus FKGQNP--------------------------------FELAFSLDL-AQHRDSDF-SPQ MNK1_Mmus ------------------------------------------------------------ R166.5_Cele FGRHHNVNINQLNLNHLGQVDNIPNNSAVGGGGAAFHHLHTSAATPRHVATSEFYDDEEA Mnk_Spur -QVLQP--------------------------------VMRSFVFPT-VCPQDSYP-SQE AqueK075_Aque IKSLKE--------------------------------FQKSFKLGK-SEQSNSVL-SPH MNK2_Hsap ------------------CSARP------------------------------------- MNK1_Hsap ----------------------I------------------------------------- Lk6_Dmel NHPRGSGDSGIRSGSGISCSNT-DNSCSQSQSDGQNELTRYSSEDV--SGN---ESSEAP MNK2_Mmus ------------------CEARP------------------------------------- MNK1_Mmus ------------------------------------------------------------ R166.5_Cele TSPRGGIEIG--AGGGKMMANL-R-------RHRQRERETYEDEDVLSSSD---ESSGRP Mnk_Spur TTPITKMP----TGDKMTVSQRPPATAAVQMPDCKATAENYANNNI--ADETCLLSEQMD AqueK075_Aque ---------------------------------------------V--NGS---DCSQRE MNK2_Hsap -------------------------------------------DMPASQP-ID---IPD- MNK1_Hsap -------------------------------------------EMGSSEP-LP---IAD- Lk6_Dmel -------------------------------------------NMTEVERQAE---LNRH MNK2_Mmus -------------------------------------------DMPSSQP-ID---IPD- MNK1_Mmus --------------------------------------------MGSSEP-LP---IVD- R166.5_Cele IPRYVGRDTDHVFGEFEMDDEDVVMRREDGYGEDETDEDYFDEEEPVAEL-LP---LGG- Mnk_Spur -------------------LM--------------------M-SISSVED-FHS--GLD- AqueK075_Aque VP-----------------RS--------------------L-D-ITAQP-VSRGQANTS : MNK2_Hsap AKKRGKKKKRGRATDSF-SGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEK MNK1_Hsap GDRRRKKKRRGRATDSL-PGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEK Lk6_Dmel KEEMQKKRRKKRISSSLHSSTFQELYKLTGEILGEGAYASVQTCVNIYTDLEYAVKVIDK MNK2_Mmus AKKRGRKKKRCRATDSF-SGRFEDVYQLQEDVLGEGAHARVQTCVNLITNQEYAVKIIEK MNK1_Mmus SDKRRKKKRKTRATDSL-PGKFEDVYQLTSELLGEGAYAKVQGAVNLQSGKEYAVKIIEK R166.5_Cele GTR-RVPRTPGRKNSS-K-CGFFDYYKLTDEHLGSGAYGSVTTCKSIKSGVEYAVKIVDK Mnk_Spur DSRRKRKKKKKRTSGIV-PNRFEDVYDLTGELLGSGSYASVRTCRQISSGKEYAVKMMEK AqueK075_Aque KKKKQKKKRLKPIPDDI-DYSFNDLYELTSEILGSGARATVITCIKRTTRQQYAAKIINN . : . * : *.* : **.*: . * . . . :**.*:::: MNK2_Hsap QP-GHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRH MNK1_Hsap QA-GHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKH Lk6_Dmel IP-GHARARVFREVETFHHCQGHLGILQLIEFFEDDEKFYLVFEKINGGPLLSRIQEHIC MNK2_Mmus QL-GHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHRRRH MNK1_Mmus QA-GHSRSRVFREVETLYQCQGNRNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKRKH R166.5_Cele QGETHSRKRILREVNIFKTCKDHPNIVQLLDWFEDETNFYLVMEKMRGGPLLQHILQRKY Mnk_Spur RP-GNSRTKIFREVETLYHCQGHNNILQLIEYFEDDDRFYLIFEKMYGGALLQHIEQRGT AqueK075_Aque SG-PEVRDRVLKEVEILYSCSSCDNFLKIEDFFETSEKFYLVFEKMEG-PLLELIQKRER . * ::::**: : *.. ..::: ::** . .***::**: * .:* * .: MNK2_Hsap FNELEASVVVQDVASALDFLHNK------------------------------------- MNK1_Hsap FNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQV Lk6_Dmel FSEHEASQIIKEIASGLDFLHKK------------------------------------- MNK2_Mmus FNELEASVVVQDVASALDFLHNK------------------------------------- MNK1_Mmus FNEREASRVVRDVATALDFLHTK------------------------------------- R166.5_Cele FTEEEARRVTKDISLALKFMHDR------------------------------------- Mnk_Spur FTEQEASQVIRDIASALSFLHNK------------------------------------- AqueK075_Aque FTEREASEVTREVAAALSFLHRQ------------------------------------- *.* ** : :::: .*.*:* : MNK2_Hsap ----GIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGD-CSP----ISTPELLTP MNK1_Hsap AGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNS-CTP----ITTPELTTP Lk6_Dmel ----GIAHRDLKPENILCVKTDSLCPIKICDFDLGSGIKFTTDISSP----AATPQLLTP MNK2_Mmus ----GIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGD-CSP----ISTPELLTP MNK1_Mmus ----GIAHRDLKPENILCESPEKVSPVKICDFDLGSGVKLNNS-CTP----ITTPELTTP R166.5_Cele ----GIAHRDVKPENVLCTDPNHVSPVKLCDLDLASQRPPQHE-RHPLSQVASEPDLASP Mnk_Spur ----GIAHRDLKPENILCESMYSISPIKICDFGLGSGIHLSSQYNTP----VTTPELLTP AqueK075_Aque ----GIAHRDLKPENILCQTKDEVVPIKVCDFDLSSMM---SQ-HTP----ATTPNLFTP ******:****:** : *:*:**:.*.* . * : *:* :* MNK2_Hsap CGSAEYMAPEVVEAFSE--EASIYDKRCDLWSLGVILYILLSGYPPFVGRCG-SDCGWDR MNK1_Hsap CGSAEYMAPEVVEVFTD--QATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCG-ADCGWDR Lk6_Dmel VGSAEFMAPEVVDLFVG--EAHYYDKRCDLWSLGVIAYILLCGYPPFSGNCG-EDCGWNR MNK2_Mmus CGSAEYMAPEVVEAFSE--EASIYDKRCDLWSLGVILYILLSGYPPFVGHCG-SDCGWDR MNK1_Mmus CGSAEYMAPEVVEVFRD--EATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCG-ADCGWDR R166.5_Cele VGSAEFMAPEVVDAYVG--DSLKYDKKCDTWSLGVILYIMLAGYAPFQGMCDDEDCGWSE Mnk_Spur VGSAEFMAPEIVEAFIYDLQATVYDKRCDLWSLGVILYILLCGHPPFVGSCG-EDCGWDR AqueK075_Aque VGSAEYMAPEVLDTFTG--EIFSYDKKCDLWSLGVLVYMMLSGSPPFTGGCR-TDCGWEK ****:****::: : : ***:** *****: *::*.* .** * * ****.. MNK2_Hsap GEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQR----------- MNK1_Hsap GEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQR----------- Lk6_Dmel GENCRTCQELLFESIQEGHFSFPEAEWHDVSDEAKDLISNLLVKKASNR----------- MNK2_Mmus GEACPACQNMLFESIQEGKYEFPDKDWSHISFAAKDLISKLLVRDAKQR----------- MNK1_Mmus GEVCRMCQNKLFESIQEGKYEFPDKDWAHISNEAKDLISKLLVRDAKQR----------- R166.5_Cele GKPCEDCQQDLFHRIQDGYYEFPEEEWGMISEEAKDLVSNLLKRDPVDRLVTVSFVNPFA Mnk_Spur GEACQDCEELLLHCIQSGEYDFHGAEWEHISAGAKDLISHLLVRDAKQR----------- AqueK075_Aque GEECEKCQAILLEKIGKGQYSFPQEIWASISSEAKDLISSLLQRDVRKR----------- *: * *: *:. * .* :.* * :* ****:* ** :. .* MNK2_Hsap ---------------------------------------------LSAAQVLQHPWVQGC MNK1_Hsap ---------------------------------------------LSAAQVLQHPWVQGQ Lk6_Dmel ---------------------------------------------LSAEAVLNHPWIRMC MNK2_Mmus ---------------------------------------------LSAAQVLQHPWVQGC MNK1_Mmus ---------------------------------------------LSAAQVLQHPWVQGQ R166.5_Cele NRIRLTLVAQSVACAIPTQPIVGSIPSYPALSLFIDCGAWKWRRKFNADQILSHRWLQQS Mnk_Spur ---------------------------------------------YTAGMVLNHPWVKQ- AqueK075_Aque ---------------------------------------------LSADEVLAHPWIKTE .* :* * *:: MNK2_Hsap APE----------NTLPTPMV-LQRN-SCAKDLTSFAAEAIAMNRQLAQHDEDL------ MNK1_Hsap APE----------KGLPTPQV-LQRN-SSTMDLTLFAAEAIALNRQLSQHEENE------ Lk6_Dmel EQEPPASKHGRRHKALQTPSN-IRRNHQSAREISQFAESAMAVKRVVLQHFSMRYDYMKE MNK2_Mmus APE----------NTLPTPLV-LQRN-SCAKDLTSFAAEAIAMNRQLAQCEEDA------ MNK1_Mmus APE----------RGLPTPQV-LQRN-SSTMDLTLFAAEAIALNRQLSQHEENE------ R166.5_Cele AAS----------TILQTPSNLINRK-DSARDVQQMSEHFNLMNRLADTRLSAR------ Mnk_Spur PPS----------TPLLTPAI-IKRN-NSAKDLSQFAADAVACNRLVAQKEEDE------ AqueK075_Aque VPD----------TPLKTPGV-LRLNPSITDELSQVAASCLKCNRRLSTHFEK------- . * ** :. : . : :: .: :* . MNK2_Hsap ------------------------------------------------------------ MNK1_Hsap ------------------------------------------------------------ Lk6_Dmel RPNIYQPSQAYMDAYSDENYNPKPPGHYTRNRSQRNPASSLCGYGGRMSSMHGQRANSRR MNK2_Mmus ------------------------------------------------------------ MNK1_Mmus ------------------------------------------------------------ R166.5_Cele ------------------------------------------------------------ Mnk_Spur ------------------------------------------------------------ AqueK075_Aque ------------------------------------------------------------ MNK2_Hsap ------------------------------------------------------------ MNK1_Hsap ------------------------------------------------------------ Lk6_Dmel SSRNASRNASAIYPNSGGFKTLNVHEEDDDDEGLEAFGHIDDDDEWSRSRREYQQQCETL MNK2_Mmus ------------------------------------------------------------ MNK1_Mmus ------------------------------------------------------------ R166.5_Cele ------------------------------------------------------------ Mnk_Spur ------------------------------------------------------------ AqueK075_Aque ------------------------------------------------------------ MNK2_Hsap ------------------------------------------------------------ MNK1_Hsap ------------------------------------------------------------ Lk6_Dmel GEDRFRRQSGSEGDEVEDDEDGENEDYQHYKHYWRELDEEEGDDYLYEQQQRVDDKFGEE MNK2_Mmus ------------------------------------------------------------ MNK1_Mmus ------------------------------------------------------------ R166.5_Cele ------------------------------------------------------------ Mnk_Spur ------------------------------------------------------------ AqueK075_Aque ------------------------------------------------------------ MNK2_Hsap ------------------------------------------------------------ MNK1_Hsap ------------------------------------------------------------ Lk6_Dmel EFEDEPKEETQADNLKLSKAYVEQVGETNVEKSKPQDDNGGYIREDLIMDNMDMKKNTQQ MNK2_Mmus ------------------------------------------------------------ MNK1_Mmus ------------------------------------------------------------ R166.5_Cele ------------------------------------------------------------ Mnk_Spur ------------------------------------------------------------ AqueK075_Aque ------------------------------------------------------------ MNK2_Hsap -------------------AE--------EEAAGQ------------------------- MNK1_Hsap -------------------LA--------E------------------------------ Lk6_Dmel SEFAKLTIMRNDAQTEENKIMQQQDEEKKEEKQQDDVDGAKKQGPSSDISATTITDNNKL MNK2_Mmus -------------------GQ--------D------------------------------ MNK1_Mmus -------------------LA--------E------------------------------ R166.5_Cele -------------------FD--------NKMTMSE--C--------------------- Mnk_Spur -------------------IQ--------EEVIEEDVDT--------------------- AqueK075_Aque ------------------------------------------------------------ MNK2_Hsap ------------------------------------------------------------ MNK1_Hsap ------------------------------------------------------------ Lk6_Dmel QTPVMTTTHINNWQTGDAIEDDDVKLLDSISDLNEKLPEIYETANIVVNSAAVPAASTPA MNK2_Mmus ------------------------------------------------------------ MNK1_Mmus ------------------------------------------------------------ R166.5_Cele ------------------------------------------------------------ Mnk_Spur ------------------------------------------------------------ AqueK075_Aque ------------------------------------------------------------ MNK2_Hsap ----------------------------------------GQP----------------- MNK1_Hsap -----------------------------------------EP----------------- Lk6_Dmel ASATRPPTDNPEEDDSNVTKPTTTAEGTTMQTTFGMSAEEEKPVALSHTAGHHSKTGRTV MNK2_Mmus -----------------------------------------QP----------------- MNK1_Mmus -----------------------------------------EQ----------------- R166.5_Cele -------------------------------------GSDLGTATIHGD----------- Mnk_Spur -------------------------------------EDDGGICIIRPS----------- AqueK075_Aque ------------------------------------------------------------ MNK2_Hsap ------------------------------------------------------------ MNK1_Hsap ------------------------------------------------------------ Lk6_Dmel NFAPDAYQNDEDADIDEDDDYDDEENLHEHSKQQLPSNAYTRKQRQQHQRYIVPRYQLAD MNK2_Mmus ------------------------------------------------------------ MNK1_Mmus ------------------------------------------------------------ R166.5_Cele ------------------------------------------------------------ Mnk_Spur ------------------------------------------------------------ AqueK075_Aque ------------------------------------------------------------ MNK2_Hsap ------------------------------------------------------------ MNK1_Hsap ------------------------------------------------------------ Lk6_Dmel QVPQRQHTENWRYRTHHSQEQQPTADYRKYRPPFSTGGGGGHHGNQQRNYLGSFSHSGGA MNK2_Mmus ------------------------------------------------------------ MNK1_Mmus ------------------------------------------------------------ R166.5_Cele ------------------------------------------------------------ Mnk_Spur ------------------------------------------------------------ AqueK075_Aque ------------------------------------------------------------ MNK2_Hsap ------------------------------------------------------------ MNK1_Hsap ------------------------------------------------------------ Lk6_Dmel AGYKIAPMPPPMQPPPRHNSAGSSGSGSGSGGSPPSDEQSAIRNWRQDCVYARSCGMNQG MNK2_Mmus ------------------------------------------------------------ MNK1_Mmus ------------------------------------------------------------ R166.5_Cele -----------------------------------------------------G------ Mnk_Spur -----------------------------------------------------G------ AqueK075_Aque ------------------------------------------------------------ MNK2_Hsap ------------------------------VLVRAT-------------------SRCL- MNK1_Hsap ------------------------------EALADG-------------------LCSM- Lk6_Dmel PEQQRHNRSSGQRVQQQPRIGSGRFAHLQAAQLMDEL-----------------PDMRI- MNK2_Mmus ------------------------------VVIRAT-------------------SRCL- MNK1_Mmus ------------------------------EALAEG-------------------LCSM- R166.5_Cele ------------------------------SFLSMGGEPFGTFPRKKSVGIAIEKSRSGE Mnk_Spur ------------------------------QLNNGG-------------------LNNF- AqueK075_Aque ---------------------------------------------------------SF- MNK2_Hsap ----------QLSPPSQSKL--------AQRRQRASLSS-----------------APVV MNK1_Hsap ----------KLSPPCKSRL--------ARRRALAQAGR-----------------GEDR Lk6_Dmel ----------GLSPPSESVL--------LQRRLRQQ-QR-----------------ANDL MNK2_Mmus ----------QLSPPSQSKL--------AQRRQRASLSA-----------------TPVV MNK1_Mmus ----------KLSPPSKSRL--------ARRRALAQAGR-----------------SRDA R166.5_Cele FTPPISRASPTTPPPSMLNLSEDLTDSPVKRRSADDSGTFSLFSPASSNGDDSICSPPMV Mnk_Spur ----------GLSPPGQSAL--------AKRRAAMH-SQ-----------------GRDQ AqueK075_Aque ----------KLSPPGSSEL--------ALRRGGDHK----------------------- .** * ** MNK2_Hsap -------------------------------------------------LVGDHA MNK1_Hsap -------------------------------------------S------PPTAL Lk6_Dmel -------------------------------------------SEY-CEPATASG MNK2_Mmus -------------------------------------------------LVGDRA MNK1_Mmus -------------------------------------------NP--C-LTPAGL R166.5_Cele FVDMPSIQLFGTGALLTSVQMTPRHTTEDDASLKSFEDEQENANPIHRIETQVNV Mnk_Spur -------------------------------------------------CITIQA AqueK075_Aque -----------------------------------------------------FP