CLUSTAL W (1.83) multiple sequence alignment mig-15_Cele MSSS-----------GLDEIDLNSLRDPAGIFELIEVVGNGTYGQVYKGRHVKTAQLAAI msn_Dmel MAHQQQQQLAPSVNCSLDDIDLTALKDPAGIFELIEVVGNGTYGQVYKGRHTKTGQLAAI HGK_Mmus MAND-------SPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAI TNIK_Mmus MASD-------SPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAI MINK_Mmus MGDP-------APARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAI NRK_Mmus MAGP-------GGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAV MSN_Spur -------------------IDLKGLRDPSGVFHVLKKMGNGFRGSVMRSYHRKKGILKRI NRK_Hsap MAGP-------GGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAV MINK_Hsap MGDP-------APARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAI TNIK_Hsap MASD-------SPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAI HGK_Hsap MAND-------SPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAI AqueK232_Aque MSP----------FKRR-----VQTKDPEGIFELIEVVGNGTYGQVFKGRHVKTGQLAAI ** *:* : : :* * * : . * *.. : : mig-15_Cele KIMNIN------------------------EDEEDEIKLEINMLKKHSHHRNVATYYGAF msn_Dmel KVMDVT------------------------EDEEEEIKLEINVLKKYSNHRNIATYYGAF HGK_Mmus KVMDVT------------------------EDEEEEIKLEINMLKKYSHHRNIATYYGAF TNIK_Mmus KVMDVT------------------------GDEEEEIKQEINMLKKYSHHRNIATYYGAF MINK_Mmus KVMDVT------------------------EDEEEEIKQEINMLKKYSHHRNIATYYGAF NRK_Mmus KVMNARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAF MSN_Spur ALTMVT------------------------GNFREQLKSFSFLFVQYSHHRNIATYYGAF NRK_Hsap KVMNARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAF MINK_Hsap KVMDVT------------------------EDEEEEIKQEINMLKKYSHHRNIATYYGAF TNIK_Hsap KVMDVT------------------------GDEEEEIKQEINMLKKYSHHRNIATYYGAF HGK_Hsap KVMDVT------------------------EDEEEEIKLEINMLKKYSHHRNIATYYGAF AqueK232_Aque KIMEVT------------------------EDEEEEIRLEVDVLRKYSYHTNIATYYGAF : : .:::: :: ::* * *:.::**** mig-15_Cele IKKLPSSTGKHDQLWLVMEFCGSGSITDLVKNTKGGSLKEEWIAYICREILRGLYHLHQS msn_Dmel IKKSP--PGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYICREILRGLSYLHSN HGK_Mmus IKKSP--PGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIH TNIK_Mmus IKKNP--PGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQH MINK_Mmus IKKSP--PGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAH NRK_Mmus FKLSP--PGQRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAH MSN_Spur IKKGV--KNHDDQLWLVMEFCGAGSVTDLVKATKGNALKEEWIAYICREILR-------- NRK_Hsap FKLSP--PGQRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAH MINK_Hsap IKKSP--PGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAH TNIK_Hsap IKKNP--PGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQH HGK_Hsap IKKSP--PGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIH AqueK232_Aque VKKSE--PGTEDQLWLVMEFCGAGSITDLVKSTKTRSLKEEWIAYVAREVLRGLSHLHKN .* . .***:*** *.:**:**::: *. :***: ***:.**:*: mig-15_Cele KVIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDKTVGRRNTFIGTPYWMAPEVIACDESPE msn_Dmel KVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACDENPD HGK_Mmus HVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPD TNIK_Mmus KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPD MINK_Mmus KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPD NRK_Mmus RVIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPR MSN_Spur --------------------KIVDFGVSAQLDKTIGRRNTFIGTPYWMAPEVIACDENPD NRK_Hsap RVIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPR MINK_Hsap KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPD TNIK_Hsap KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPD HGK_Hsap HVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPD AqueK232_Aque KVIHRDIKGQNVLLTDNADIKLVDFGVSAQLDRTIGKRNTFIGTPYWMAPEVIACDQDPH *:********:.:* *:**:************* **:.* mig-15_Cele ATYDSRSDLWSLGITALEMAEGHPPLCDMHPMRALFLIPRNPPPKLKRNKKWTKKFETFI msn_Dmel ATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNSPPRLK-SKKWSKKFHGFI HGK_Mmus ATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLK-SKKWSKKFFSFI TNIK_Mmus ATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLK-SKKWSKKFQSFI MINK_Mmus ATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLK-SKKWSKKFIDFI NRK_Mmus RSYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVK-SSGWSRKFHNFM MSN_Spur ATYDNKSDLWSLGITALEMAEGQPPLCDMHPMRALFLIPRNPKPKLK-SKKWNKKFMDFV NRK_Hsap RSYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVK-SSGWSRKFHNFM MINK_Hsap ATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLK-SKKWSKKFIDFI TNIK_Hsap ATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLK-SKKWSKKFQSFI HGK_Hsap ATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLK-SKKWSKKFFSFI AqueK232_Aque ATYDYRSDQWSLGITSIEIAEGEPPLCSMHPMRALFLIPRNPPPRLKMPKKWSPKFTSFI :** :** ** ***::*:**. ****.::*:.***:* *:. * :* . *. ** *: mig-15_Cele ETVLVKDYHQRPYTGALLRHPFIKEQPHEQTIRHSIKEHIDRNRR--VKKDDA-DYEYSG msn_Dmel DTVLVKDYHQRPYTENLLKHGFIKDQPTDRQVRIQLKDHIDRCKKRKQEKERE-DYRYSG HGK_Mmus EGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDET-EYEYSG TNIK_Mmus ESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDET-EYEYSG MINK_Mmus DTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEET-EYEYSG NRK_Mmus EKCTIKNFLFRPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREE MSN_Spur DKCLIKNYQQRPDTNQLLKHSFIKDLPNERQVRIQLKDHIDRTPRE---DLST-DYEYNS NRK_Hsap EKCTIKNFLFRPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREE MINK_Hsap DTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEET-EYEYSG TNIK_Hsap ESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDET-EYEYSG HGK_Hsap EGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDET-EYEYSG AqueK232_Aque DQCLTKDPTKRPTSDELLRHPFVNDFP-ERQVRIQMKDQIDRMKRKKVMDDHL-SSDEEG : * ** : :::. *:.: :: : .:. :: : . . mig-15_Cele SEDDEPS-PNNRGPSMG--IR-------------DDS--ESSSMIPMDNT---------- msn_Dmel SDNDDDE-PQLAGEH------------------------SSIVQAPGGDT---------- HGK_Mmus SEEEEEEVPEQEGEP------------------------SSIVNVPGEST---------- TNIK_Mmus SEEEEEE--NDSGEP------------------------SSILNLPGEST---------- MINK_Mmus SEEEDDS-HGEEGEP------------------------SSIMNVPGEST---------- NRK_Mmus AIKEQYTVRRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQQLQ MSN_Spur NESDEEPEIEDEGEP------------------------SSILPGPSEST---------- NRK_Hsap AIKEQYTVRRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQQLQ MINK_Hsap SEEEDDS-HGEEGEP------------------------SSIMNVPGEST---------- TNIK_Hsap SEEEEEE--NDSGEP------------------------SSILNLPGEST---------- HGK_Hsap SEEEEEEVPEQEGEP------------------------SSIVNVPGEST---------- AqueK232_Aque SLEQPT-I-KKGGG---------------------------------------------- .: * mig-15_Cele -LRKGFQKLQESSRGFAEPGAQQ-LRRLPQQPA--------------------------- msn_Dmel -LRRNFQQIQEG-RLAAEQQQQHHLMAQAQAQAA---AAHAAAQAQAQLQQQQQQAA--- HGK_Mmus -LRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLE TNIK_Mmus -LRRDFLRLQLANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLE MINK_Mmus -LRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVE NRK_Mmus GAARVFMPLQALDS-APKPLKGQAQAPQRLQGA--AR-VFMPLQAQVKAKASKPLQMQIK MSN_Spur -LRRNFLRLQQQQQQQEEGG-----------------------------------RRRLE NRK_Hsap GAARVFMPLQALDS-APKPLKGQAQAPQRLQGA--AR-VFMPLQAQVKAKASKPLQMQIK MINK_Hsap -LRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVE TNIK_Hsap -LRRDFLRLQLANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLE HGK_Hsap -LRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLE AqueK232_Aque ------------------------------------------------------------ mig-15_Cele -----PAPFQYQQSRYVEPRRESSE----------------VKLRAVSSRGAAD------ msn_Dmel ------------------------------------------------------------ HGK_Mmus EQQRREREARRQQERE--QRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYI TNIK_Mmus EQQRREKELRKQQERE--QRRHYEEQM-----------------RREEERRRAEHEQEYI MINK_Mmus EQQRREREQRKLQEKE--QQRRLEDM---------------QALRREEERRQAEREQEYK NRK_Mmus APPRLRRAARVLMPLQ--AQVRAPRL---------------LQVQSQVSKKQQAQTQTSE MSN_Spur DD---------------------------------------------------------- NRK_Hsap APPRLRRAARVLMPLQ--AQVRAPRL---------------LQVQSQVSKKQQAQTQTSE MINK_Hsap EQQRREREQRKLQEKE--QQRRLEDM---------------QALRREEERRQAEREQEYK TNIK_Hsap EQQRREKELRKQQERE--QRRHYEEQM-----------------RREEERRRAEHEQEYI HGK_Hsap EQQRREREARRQQERE--QRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYI AqueK232_Aque ------------------------------------------------------------ mig-15_Cele -----------------------------------------GPRHSPAS----------- msn_Dmel ------------AAAAAAAHAAQQAQQAA----------------------------QQA HGK_Mmus RRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDH TNIK_Mmus RRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQR MINK_Mmus -----------------------------RKQLEEQRQSERLQRQLQQEHAYLKSLQQQQ NRK_Mmus -----------------------------PQDLDQVPEEFQGQDQVPEQQRQGQAPEQQQ MSN_Spur ------------------------------------------------------------ NRK_Hsap -----------------------------PQDLDQVPEEFQGQDQVPEQQRQGQAPEQQQ MINK_Hsap -----------------------------RKQLEEQRQSERLQRQLQQEHAYLKSLQQQQ TNIK_Hsap RRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQR HGK_Hsap RRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDH AqueK232_Aque ------------------------------------------------------------ mig-15_Cele -RPRPVSHHQRSP--Q-QSHPAAPHLADLANYEKRRRS-EREERRERERQA-HHAMPIAR msn_Dmel QAQQPQ---------AN-RQP------------KPPSRQQVEE----------------- HGK_Mmus RRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNH-SSPEAQ-SK TNIK_Mmus QEQRPV-----------EKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQ-SSPAMP-HK MINK_Mmus QQQQLQKQQQQQLLPG-DRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAK-SK NRK_Mmus RHNQVPEQELEQNQAPE--QPEVQ-EQAAEPAQAETEAEE-PESLRVNAQVFLPLLS-QD MSN_Spur ------------PPST------------------------------------NPLMR-SA NRK_Hsap RHNQVPEQELEQNQAPE--QPEVQ-EQAAEPAQAETEAEE-PESLRVNAQVFLPLLS-QD MINK_Hsap QQQQLQKQQQQQLLPG-DRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAK-SK TNIK_Hsap QEQRPV-----------EKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQ-SSPAMP-HK HGK_Hsap RRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNH-SSPEAQ-SK AqueK232_Aque ------------------------------------------------------------ mig-15_Cele VSASVPAP---QQSRKM--S---EPLLITHVKPEDLDVL-----ASELSKMGGHHNGRSR msn_Dmel -------------------PG-PPAR-PPQRLIVVPDP-PHANRP--LPPT-P-KCGEPA HGK_Mmus QTGRVLEPPVPSRSESFSN-GNSESVHPALQRPAEPQVQ-----WSHLASLKNNVSPVSR TNIK_Mmus VANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQI-------PHLVAVKSQGPALTA MINK_Mmus PGSTGPEPPIPQASPGP--PG-PLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPR NRK_Mmus H---------------------------HVLLPLHLDT-------QVLIPVEGQTEGSPQ MSN_Spur PSRAGPV----------------------------------------------------- NRK_Hsap H---------------------------HVLLPLHLDT-------QVLIPVEGQTEGSPQ MINK_Hsap PGSTGPEPPIPQASPGP--PG-PLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPR TNIK_Hsap VANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQI-------PHLVAVKSQGPALTA HGK_Hsap QTGRVLEPPVPSRSESFSN-GNSESVHPALQRPAEPQVQ-----WSHLASLKNNVSPVSR AqueK232_Aque ------------------------------------------------------------ mig-15_Cele EESMS-----------------------------------------------P-P----- msn_Dmel GQTPQQQQRNSQNNFKPSLPPRRPEDHLDVLAAQLSELGVVFSQQPQPQTAAGGQGSQQ- HGK_Mmus SHSFSDPSPKFAHHHLRS---QDP---------CPPSRSEVLSQSSDSKSEAP--DPT-- TNIK_Mmus SQSVHEQPTKGLSGFQEA---L-N---------VTSHRVEMPRQNSDPTSENP-PLPTRI MINK_Mmus SQSLQDQPTRNLAAFPAS---HDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPN-- NRK_Mmus AQAWTLEPPQAIGSVQAL---I-E---------GLS-RDLLRAPNSNNSKPLG-PLQTLM MSN_Spur ---------------------------------------------------------N-- NRK_Hsap AQAWTLEPPQAIGSVQAL---I-E---------GLS-RDLLRAPNSNNSKPLG-PLQTLM MINK_Hsap SQSLQDQPTRNLAAFPAS---HDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPN-- TNIK_Hsap SQSVHEQPTKGLSGFQEA---L-N---------VTSHRVEMPRQNSDPTSENP-PLPTRI HGK_Hsap SHSFSDPSPKFAHHHLRS---QDP---------CPPSRSEVLSQSSDSKSEAP--DPT-- AqueK232_Aque ------------------------------------------------------------ mig-15_Cele ----------------PPAPPPREASISSITDT-IDVGELDNGADAEWDDLKDIMMNG-E msn_Dmel ---------QAQ-PEAPPRNNRQSSGLSSSGGSASGGG-------------------GSS HGK_Mmus ----QKAWSRSDSDEVPPRVPVRTTSRSPVLSR-RDSP-------------------L-Q TNIK_Mmus EKFDRSSWLRQE-EDIPPKVPQRTTSISPALAR-KNSP-------------------G-N MINK_Mmus ----PPAWVRPD-NEAPPKVPQRTSSIATALNT-SGAG-------------------G-S NRK_Mmus ENLSSNRFYSQP-EQAREKK-SKVSTLRQALAK-RLSP-------------------K-R MSN_Spur ----PPCHPHPP-AESRPKLRQGSAKLSVCRNV-TVTS-------------------S-S NRK_Hsap ENLSSNRFYSQP-EQAREKK-SKVSTLRQALAK-RLSP-------------------K-R MINK_Hsap ----PPAWVRPD-NEAPPKVPQRTSSIATALNT-SGAG-------------------G-S TNIK_Hsap EKFDRSSWLRQE-EDIPPKVPQRTTSISPALAR-KNSP-------------------G-N HGK_Hsap ----QKAWSRSDSDEVPPRVPVRTTSRSPVLSR-RDSP-------------------L-Q AqueK232_Aque -------------------------------DT-TGSG-------------------G-- mig-15_Cele GTLRGPNKPLPP------------------------------------------------ msn_Dmel KPAAALP--QQS------------------------------------------------ HGK_Mmus GSGQQNSQAGQR------------------------------------------------ TNIK_Mmus GSALGPRLGSQP------------------------------------------------ MINK_Mmus RPAQAVRA--RP------------------------------------------------ NRK_Mmus FRAKSS-WRPEKLELSDLEARRQRRQRRWEDIFNQHEEELRQVDKDKEDESSDNDEVFHS MSN_Spur LRAMSWRS--WN------------------------------------------------ NRK_Hsap FRAKSS-WRPEKLELSDLEARRQRRQRRWEDIFNQHEEELRQVDKDKEDESSDNDEVFHS MINK_Hsap RPAQAVRA--RP------------------------------------------------ TNIK_Hsap GSALGPRLGSQP------------------------------------------------ HGK_Hsap GSGQQNSQAGQR------------------------------------------------ AqueK232_Aque ------------------------------------------------------------ mig-15_Cele ---------------------------------------------TPTDGENTLVSDVRR msn_Dmel ---------------------------------------NNH------------------ HGK_Mmus ---------------------------------------NSTSSIEPRLLWERVEKLVPR TNIK_Mmus ---------------------------------------IRASNPDLRRTEPILESPLQR MINK_Mmus ---------------------------------------RS-NSAWQIYLQRRAERGTPK NRK_Mmus IQAEVQIEPLKPYISNPKKIEVQERSPSVPNNQDHAHHVKFSSSVPQRSLLEQAQKPIDI MSN_Spur ---------------------------------------AD-ITLCPIFYE--------- NRK_Hsap IQAEVQIEPLKPYISNPKKIEVQERSPSVPNNQDHAHHVKFSSSVPQRSLLEQAQKPIDI MINK_Hsap ---------------------------------------RS-NSAWQIYLQRRAERGTPK TNIK_Hsap ---------------------------------------IRASNPDLRRTEPILESPLQR HGK_Hsap ---------------------------------------NSTSSIEPRLLWERVEKLVPR AqueK232_Aque ------------------------------------------------------------ mig-15_Cele NGN--GNSGHG------------------AYKGKKIP----EIRPGII------------ msn_Dmel -LGQPVNPLDPLD-SSDSDSEPDEPNDRARNDG-TLLASDP-P--KPLPG---------- HGK_Mmus PGS--GSSSGS------------------SNSG-SQP----GSHPGSQSGSGERFRV--- TNIK_Mmus TSS--GSSSSS------------------STPS-SQPSSQGGSQPGSQAGSSERTRV--- MINK_Mmus PPGPPAQPPGPPNASSNPDLRRSDPG-WERSDS-VLPASHG-H--LPQAGSLERNRV--- NRK_Mmus RQR-S-SQN---------------------RQN-WLAASES--------SSEEESPVTGR MSN_Spur ------------------------------------------------NFKLDLTMA--- NRK_Hsap RQR-S-SQN---------------------RQN-WLAASES--------SSEEESPVTGR MINK_Hsap PPGPPAQPPGPPNASSNPDLRRSDPG-WERSDS-VLPASHG-H--LPQAGSLERNRV--- TNIK_Hsap TSS--GSSSSS------------------STPS-SQPSSQGGSQPGSQAGSSERTRV--- HGK_Hsap PGS--GSSSGS------------------SNSG-SQP----GSHPGSQSGSGERFRV--- AqueK232_Aque -----------------------------------K------------------------ mig-15_Cele ------------------------------------------------------------ msn_Dmel --------LGPVSEDAN-TTTPLSHGSGGPPNRPLP------------------------ HGK_Mmus -RSSSKSEGSPSQRLENAVKKPEDKKE---VFRPLKPAG-----EVDLTALAKEL----- TNIK_Mmus -RANSKSEGSPVLPHEPAKVKPEESRD---ITRPSRPASYKKAIDEDLTALAKELRE--L MINK_Mmus -GVSSKPDSSPVLSPGN-KAKPDDHR-----SRPGRPASYKRAIGEDFV-LLKE-----R NRK_Mmus RSQSSPPYSTIDQKLLVDIHVPDGFKV----GK-ISPPVYLTNEWVGYNALSEIFRNDWL MSN_Spur -GHSAYVDSHHVLALALK-RRSQGHK-----SAK-------------------------- NRK_Hsap RSQSSPPYSTIDQKLLVDIHVPDGFKV----GK-ISPPVYLTNEWVGYNALSEIFRNDWL MINK_Hsap -GVSSKPDSSPVLSPGN-KAKPDDHR-----SRPGRPASYKRAIGEDFV-LLKE-----R TNIK_Hsap -RANSKSEGSPVLPHEPAKVKPEESRD---ITRPSRPASYKKAIDEDLTALAKELRE--L HGK_Hsap -RSSSKSEGSPSQRLENAVKKPEDKKE---VFRPLKPAG-----EVDLTALAKEL----- AqueK232_Aque ----------P------------------------------------------------- mig-15_Cele ---------------------SLD-DDDSDSDN-EEGNEPLM----FKPIN---AS---- msn_Dmel --------P--------------T---PDDDDQAGD------------------------ HGK_Mmus RAVEDVRPPHKVTDYSSSSEESG-TTDEEDDDVEQEGADEST----SGPEDTRAAS---- TNIK_Mmus RIEETNRPMKKVTDYSSSSEESE-SSEEEEEDGESETHDGTV----AVSDIPRLIP---- MINK_Mmus TLDEAPRPPKKAMDYSSSSEEVE-SSEDDEEEGEGGPAEGSR--------DT-------- NRK_Mmus TPAPVIQPPEEDGDYVELYDASA-DTDGDDDDESNDTFEDTYDHANGNDDLDNQVDQAND MSN_Spur ------------------------------------------------------------ NRK_Hsap TPAPVIQPPEEDGDYVELYDASA-DTDGDDDDESNDTFEDTYDHANGNDDLDNQVDQAND MINK_Hsap TLDEAPRPPKKAMDYSSSSEEVE-SSEDDEEEGEGGPAEGSR--------DT-------- TNIK_Hsap RIEETNRPMKKVTDYSSSSEESE-SSEEEEEDGESETHDGTV----AVSDIPRLIP---- HGK_Hsap RAVEDVRPPHKVTDYSSSSEESG-TTDEEDDDVEQEGADEST----SGPEDTRAAS---- AqueK232_Aque --------------------KTEDEDDDDDDDILGAAGD-TI----LT---TR------- mig-15_Cele ----------------------------------------------------------S- msn_Dmel ------------------------------------------------------------ HGK_Mmus ----------------------------------------------------------SL TNIK_Mmus ----------------------------------------------------------TG MINK_Mmus ----------------------------------------------------------PG NRK_Mmus VCKDHDDDNNKFVDDVNNNYYEAPSCPRASYGRDGSCKQDGYDGSRGKEEAYRGYGSHTA MSN_Spur ------------------------------------------------------------ NRK_Hsap VCKDHDDDNNKFVDDVNNNYYEAPSCPRASYGRDGSCKQDGYDGSRGKEEAYRGYGSHTA MINK_Hsap ----------------------------------------------------------PG TNIK_Hsap ----------------------------------------------------------TG HGK_Hsap ----------------------------------------------------------SL AqueK232_Aque ----------------------------------------------------------EQ mig-15_Cele ---------------------------------------------------------S-- msn_Dmel ------------------------------------RTLIMKRNRGGGGGG-GGGGGGGG HGK_Mmus NLSNGET-ESVKTMIVHDDVESEP-----AMTPSKEGTLIVRQSTVDQKRA-SHH-ESNG TNIK_Mmus APGSNEQ-YNVGMVGTHGLETSHADSF--SGSISREGTLMIRETSGEKKRS-GHS-DSNG MINK_Mmus GRSDGDT-DSVSTMVVHDVEEITG-----TQPPYGGGTMVVQRTPEEERNL-LHA-DSNG NRK_Mmus NRSHGGSAASEDNAAIGDQEEHAANIGSERRGSEGDGGKGVVRTSEESGALGLNG-EENC MSN_Spur --------------------------------------FTFFDNTLLNKKL-LSK-DHNG NRK_Hsap NRSHGGSAASEDNAAIGDQEEHAANIGSERRGSEGDGGKGVVRTSEESGALGLNG-EENC MINK_Hsap GRSDGDT-DSVSTMVVHDVEEITG-----TQPPYGGGTMVVQRTPEEERNL-LHA-DSNG TNIK_Hsap APGSNEQ-YNVGMVGTHGLETSHADSF--SGSISREGTLMIRETSGEKKRS-GHS-DSNG HGK_Hsap NLSNGET-ESVKTMIVHDDVESEP-----AMTPSKEGTLIVRQSTVDQKRA-SHH-ESNG AqueK232_Aque GASDDFT-ASTDTKLSQYAEETLI-----IRPDSEPSSSFLQDSSPEQRKA--------- mig-15_Cele R------------------G-ALPDLLPKSPQLRRQINDQTRQM---------------- msn_Dmel SSGVGADGTGLGTPGTRTSS-VLPDLLSQAS-P-------------------------AT HGK_Mmus FAG---------------RIHLLPDLLQQSHSSSTSSTSSSPSSS-QPTP----TMSPQT TNIK_Mmus FAG---------------HIN-LPDLVQQSHSPAGTPTEGLGRVS-T------------- MINK_Mmus YT------------------N-LPDVVQPSHSPTENSKGQSPPS---------------- NRK_Mmus ---SETDG---------------PGLKRPASQDFEYLQEEPGGGN-EASNAIDSGAAPSA MSN_Spur ES------------------N-LPRTSQESYGTSENGKGQLLPI---------------- NRK_Hsap ---SETDG---------------PGLKRPASQDFEYLQEEPGGGN-EASNAIDSGAAPSA MINK_Hsap YT------------------N-LPDVVQPSHSPTENSKGQSPPS---------------- TNIK_Hsap FAG---------------HIN-LPDLVQQSHSPAGTPTEGLGRVS-T------------- HGK_Hsap FAG---------------RIHLLPDLLQQSHSSSTSSTSSSPSSS-QPTP----TMSPQT AqueK232_Aque ---------------------------------------DQPFSSYQPSG----GAKP-- mig-15_Cele ---SDDRADE--QPNGFQNSDSRSSI---------QHSFSNR----DREKSFVGYFGGGA msn_Dmel PPRHDKSSSEEKQR----------SFLT------------------------FGFGAGG- HGK_Mmus PQDKLTANETQSASSTLQKHKSSSSFTPFIDPRLLQISPSSG----TTVTSVVGFS---- TNIK_Mmus -----HSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFT---- MINK_Mmus ---KDGSGDY--QSRGLVKAPGKSSFTMFVDLGIYQPGGSG-----DSIPITALVG---- NRK_Mmus P-DHESDNK------DISESSTQSDFSAN------HSSPSKG----SGMSADANFA---- MSN_Spur ---RNGGSDY--RFKGLVRTKNMSSFTMFVSLMQHQPGSRG-----ETVNL-RLIG---- NRK_Hsap P-DHESDNK------DISESSTQSDFSAN------HSSPSKG----SGMSADANFA---- MINK_Hsap ---KDGSGDY--QSRGLVKAPGKSSFTMFVDLGIYQPGGSG-----DSIPITALVG---- TNIK_Hsap -----HSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFT---- HGK_Hsap PQDKLTANETQSASSTLQKHKSSSSFTPFIDPRLLQISPSSG----TTVTSVVGFS---- AqueK232_Aque ------------------------------------------GGAV---PR--------- mig-15_Cele GAGGGTVNRPGR---PQ-DINQ-VQ--VNVTPNSNGTPAENDAPEIRKYKKKFSGEILCA msn_Dmel ----------------SGPSRRESHVNVNVTPT--SHEAANDTPEIRKYKKRFNSEILCA HGK_Mmus --CDGM--RPEAI--RQDPTRKGSV--VNVNPT--NTRPQSDTPEIRKYKKRFNSEILCA TNIK_Mmus --SELL--RQEQA--KLNEARKISV--VNVNPT--NIRPHSDTPEIRKYKKRFNSEILCA MINK_Mmus --GEGT--RLDQL--QY-DVRKGSV--VNVNPT--NTRAHSETPEIRKYKKRFNSEILCA NRK_Mmus --SAIL--YAGFVEVPEESPKQPSE--VNVNPL--YVSPACKKPLIHMYEKEFTSEICCG MSN_Spur --GLAI--DLDQS--QF-LIRQSIS--VNVKPT--TPESLNDMPEIRKYRKKFNSEILCA NRK_Hsap --SAIL--YAGFVEVPEESPKQPSE--VNVNPL--YVSPACKKPLIHMYEKEFTSEICCG MINK_Hsap --GEGT--RLDQL--QY-DVRKGSV--VNVNPT--NTRAHSETPEIRKYKKRFNSEILCA TNIK_Hsap --SELL--RQEQA--KLNEARKISV--VNVNPT--NIRPHSDTPEIRKYKKRFNSEILCA HGK_Hsap --CDGM--RPEAI--RQDPTRKGSV--VNVNPT--NTRPQSDTPEIRKYKKRFNSEILCA AqueK232_Aque -----------PI--GASGGRQGEN--G--GVV--KAEVTKMNPEIRKYKRKFTSEILCG .: * *: *.:.*..** *. mig-15_Cele ALWGVNLLIGTDSGLMLLDRSGQGKVYPLISRRRFDQMTVLEGQNILATISGRKRRIRVY msn_Dmel ALWGVNLLIGTENGLMLLDRSGQGKVYQLISRRRFQQMEVLEGQNILVTISGKKNRVRVY HGK_Mmus ALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVY TNIK_Mmus ALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVY MINK_Mmus ALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVY NRK_Mmus SLWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGHKNRLRVY MSN_Spur SLWGVNLLIGTDSGLMLLDRSGEGKVYPLISRKRFQQMDVLESQNILVCIAGKKNKLRTY NRK_Hsap SLWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGHKNRLRVY MINK_Hsap ALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVY TNIK_Hsap ALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVY HGK_Hsap ALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVY AqueK232_Aque ALWGVNLLVGTDNGLMLLDRSGHGKVFPLISRRKFSQIDVLEGLNVLIGINGRKNKLRIY :*******:** ..* *:****...: ** *: * *: *** *:* * *:: ::* * mig-15_Cele YLSWLRQKILRTEGAGSANTTEKRN--------GWVNVGDLQGAIHFKIVRYERIKFLVV msn_Dmel YLSWLKSKILRTDGLS--DQVERRN--------GWINVGDLQGAVHFKIVKYERIKFLVI HGK_Mmus YLSWLRNKILHNDPE-----VEKKQ--------GWTTVGDLEGCVHYKVVKYERIKFLVI TNIK_Mmus YLSWLRNRILHNDPE-----VEKKQ--------GWITVGDLEGCIHYKVVKYERIKFLVI MINK_Mmus YLSWLRNKILHNDPE-----VEKKQ--------GWTTVGDMEGCGHYRVVKYERIKFLVI NRK_Mmus HLTWLRNKILNNDPE-----SKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETTYIAI MSN_Spur FLSWLKQKIVRSDGE-----AKRKS--------GFLSVGDLEGCIHYKIIKYEKIKFLVI NRK_Hsap HLTWLRNKILNNDPE-----SKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETTYIAI MINK_Hsap YLSWLRNKILHNDPE-----VEKKQ--------GWTTVGDMEGCGHYRVVKYERIKFLVI TNIK_Hsap YLSWLRNRILHNDPE-----VEKKQ--------GWITVGDLEGCIHYKVVKYERIKFLVI HGK_Hsap YLSWLRNKILHNDPE-----VEKKQ--------GWTTVGDLEGCVHYKVVKYERIKFLVI AqueK232_Aque YLSWLKQKIMKHELD----SPHTRQ--------GFVPVGDLEHCVHYKVARSDKMKYLVI .*:**:.:*:. : . :. . :..: . *: : : :. .::.: mig-15_Cele GLESSIEIYAWAPKPYHKF----------------------------------------- msn_Dmel ALKDSIEIYAWAPKPYHKF----------------------------------------- HGK_Mmus ALKSSVEVYAWAPKPYHKF----------------------------------------- TNIK_Mmus ALKNAVEIYAWAPKPYHKF----------------------------------------- MINK_Mmus ALKSSVEVYAWAPKPYHKF----------------------------------------- NRK_Mmus ALKSSIHLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRFKR MSN_Spur ALKDSIEIYAWAPKPYHKF----------------------------------------- NRK_Hsap ALKSSIHLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRFKR MINK_Hsap ALKSSVEVYAWAPKPYHKF----------------------------------------- TNIK_Hsap ALKNAVEIYAWAPKPYHKF----------------------------------------- HGK_Hsap ALKSSVEVYAWAPKPYHKF----------------------------------------- AqueK232_Aque GTKTGVEVYAWAQRPYSKF----------------------------------------- . : .:.:**** :.: : mig-15_Cele -------MSFKSFGSLSHVPLIVDLTVEDNARLKVLYGSTGGFHAIDLDSAAVYDIYTPA msn_Dmel -------MAFKNFGELEHRPLLVDLTIEDQSRLKVIYGSAEGFHAVDLDSAEVYDIYLPK HGK_Mmus -------MAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPT TNIK_Mmus -------MAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPS MINK_Mmus -------MAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPV NRK_Mmus PDELLHLLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTLPK MSN_Spur -------MAFKSFPNLVHRPLIVDLTVEDNQRLKVIYGSVNGFHAIDLDSASVQDIYSPP NRK_Hsap PDELLHLLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTLPK MINK_Hsap -------MAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPV TNIK_Hsap -------MAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPS HGK_Hsap -------MAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPT AqueK232_Aque -------MAFKSFPDLPNKPILVDMVHMPGGKSKVVYASTSGFHAVDMDTGVVQNIYIPA : :* * * : *: **:. : *:.:.* *:* :* :: :: * mig-15_Cele QS--------GQTTTPHCIVVLPNSNGMQLLLCYDNEGVYVNTYGRMTKNVVLQWGEMPS msn_Dmel HT--------QGAIIPHCIVALPNSNGMQLLLCYDNEGVYVNTVGRVSKNIVLQWGEMPT HGK_Mmus HVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPT TNIK_Mmus HI--------QGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPT MINK_Mmus HI--------QSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPT NRK_Mmus NP--------LEIIIPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPS MSN_Spur QE--------IGTITPYCVVILPNSQGKYLLLCFNNEGVFVDTKGVPFKDVILQWGELPA NRK_Hsap NP--------LEIIIPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPS MINK_Hsap HI--------QSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPT TNIK_Hsap HI--------QGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPT HGK_Hsap HVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPT AqueK232_Aque AAA-------RGPILPHAIIPLPSK-PSELLLCHNNEGVYVDSEGRSTKDTRLQWGEEPS * :: **. ::: .: *.: *:: *. * : *: mig-15_Cele SVAYISTGQIMGWGNKAIEIRSVDTGHLDGVFMHKKAQKLKFLCERNDKVFFSSAKGGGS msn_Dmel SVAYIGTGQIMGWGNKAIEIRSVESGHLDGVFMHKKAQRLKFLCERNDKVFFSSAKGASS HGK_Mmus SVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGS TNIK_Mmus SVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGS MINK_Mmus SVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGS NRK_Mmus SIAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHH MSN_Spur SVAYISTGQIMGWGNKAIEIRSAETGHLDGVFMHKRSQQLRFLCERNDKVFFASIRP-SN NRK_Hsap SIAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHH MINK_Hsap SVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGS TNIK_Hsap SVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGS HGK_Hsap SVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGS AqueK232_Aque SVALIGESHVMGWGSKAIEIRAVESGQLDGVFMHKRTQKLRFLCERNDKVFFASIRSTSN *:* : ***.****:*: :: *:. : :: ::*:*** *.**:**:* mig-15_Cele CQIYFMTLNKPGL----TNW msn_Dmel CQIYFMTLNKPGM----ANW HGK_Mmus SQVYFMTLGRTSL----LSW TNIK_Mmus SQVFFMTLNRNSM----MNW MINK_Mmus SQVYFMTLNRNCI----MNW NRK_Mmus SRVYFMTLGKLEELQSNYDV MSN_Spur SQVYFLTLKRNCL------M NRK_Hsap SRVYFMTLGKLEELQSNYDV MINK_Hsap SQVYFMTLNRNCI----MNW TNIK_Hsap SQVFFMTLNRNSM----MNW HGK_Hsap SQVYFMTLGRTSL----LSW AqueK232_Aque SQVYFMALNRSLVPSSSSSS .:::*::* :