CLUSTAL W (1.83) multiple sequence alignment MYT1_Hsap MLERPPALA-MPMP--TEGTPPPLSG-T-PIPVPAYFRHAEPGFSLK--RPRGLSRSLPP wee-1.3_Cele MDDTEGNSS-MDSI--RNGQSSPLPQVTPRLPQ-IPMMMRETPLSTKRERQAITPRFRRP wee-1.1_Cele MNSVLSNIEKLDTYILRRNEY--VAESK-DEPNK-LNTSRKLEVTTKK-NQSNNKKRPPP Myt1_Dmel MEKHH------------------------RLPLPE--LHDDKHRHKQ-CNGENSNRFRPP Myt1_Spur M----------------------------------------------------------- AqueK217_Aque MTDVHL-----------------------HSPRPTPFFQPEPYFSQR--RKT--PFKAPP MYT1_Mmus MTMPT------------EGTPPPLSG-T-PIPVPAYFRHAEPGFSLK--RPGGLSRSLPP * MYT1_Hsap PPPA-KGSIPISRLFPPRTPG------WHQLQPRRVSFR----GEA-SETLQSPGY-DPS wee-1.3_Cele APKMIKTMPPTRSIWS--------VR--KESVPLLVT------PQG-PKPLESPKY-DHT wee-1.1_Cele INKARKSLPSIFRRA--------EENK---DSAQIIT------PTG-SKIIGSPLY-KRS Myt1_Dmel KYKT-RGYVAVDNNNLNRSQSLGSCSTNSSQIAHAISFRDAGCSDSSTLPSSPVQAELST Myt1_Spur ------------------------------------------------------------ AqueK217_Aque KAPA-KSCPPLSRVFTSA---------VASDGPHTISFA----SDSINEPISGLRY-STD MYT1_Mmus RPPA-KGCIPVSRLFPPRTPG------WHQPQPRRVSFL----CET-SEPLQSPGY-DPS MYT1_Hsap RPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGS wee-1.3_Cele NAQSFFEQVFQIDEIIGRGSFGEVFAARCREDSQLYAVKVSLAPIRQ--HSISKYREAES wee-1.1_Cele KSDSFFDHAFNFDKNLGKGSFGEVVAATCRSTSKKFAIKKI--PFSK--LSKDQYREAYG Myt1_Dmel LSLSHFEQCFERLAKLGEGSFGEVFQVRDRSDGQLYAVKISKQLFRGEQYRAERLEEVRR Myt1_Spur ------------------------------------------------------------ AqueK217_Aque SQEPYFEQGFEIIKKIGEGSFGEVFQVKSREDGQLYAIKRSRQRFTGSWDRRKKLDEVEK MYT1_Mmus RPESFFQQNFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRYMSPFRGPKDRTRKLAEVGG MYT1_Hsap HEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLA wee-1.3_Cele HMIIPPHKNLVKFYRAWEETGRLYIQTELCDQSLLKYCTEK-HALPEDEIWNIFVDLLQA wee-1.1_Cele HMNIPCHPNIVRFHQAWIDKQILHIQLEMCDKSLAAYCHGI-DWLEDKELWNVFLDILQG Myt1_Dmel YEEFSGHENCIRFIRAWEQYDRLYMQMELCRESLEQYLLRC-QRIPEERIWHILLDLLRG Myt1_Spur -------------------------------FSLQAYAEQN-HKIPENILWGFLVDLIQG AqueK217_Aque HECLPPHPNCIRFYKAWEENLHLYIQTELCSMSLSQYCDAH-GRLPERTVWRILMDIGKG MYT1_Mmus HEKVGQHPHCVRLERAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDILLA ** : : : :* : * . MYT1_Hsap LAHLHSQGLVHLDVKPANIFLGPR-GRCKLGDFGLLVELGTA------GAGEVQEGDPRY wee-1.3_Cele VHHLHSNDMIHDDIKPENIFLTKD-MICKLGDFGLVINLKNP-----NDVKSAEEGDSKY wee-1.1_Cele LGHLHNNFMLHNDIKPDNIFMTKN-KVCKLGDFGLISDMRSEPINNSSNKHYQSEGDGKY Myt1_Dmel LKSLHDRNLIHLDIKLDNVLIGEDDETCKLADFGLVIDVDRA------NSHHATEGDSRY Myt1_Spur LAHMHSHGLLHLDVKPENIFISFH-QVCKLGDFGLSVDMDEH------DVTDTQEGDPKY AqueK217_Aque LKHLHDNRLCHLDIKPDNIFLSQSGTTWKLGDFGLVSSMDTD-------FEGASEGDACY MYT1_Mmus LDHLHSQGLVHLDVKPANIFLGPR-GRCKLGDFGLLVELGSA------GAGEAQEGDPRY : :*.. : * *:* *::: **.**** .: *** * MYT1_Hsap MAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELR wee-1.3_Cele LAPEVLNGRPTKSSDIFSLGMTILEATTDLDVPSNGDSWHQIRNGQIPDRFFAGISTDLR wee-1.1_Cele CSKEAINGTLSIFSDIFSFGISILEVGTNIHLPSYGTGWEPIRKWEIPEEILEPMSDELR Myt1_Dmel MAPEILQGHFSKAADIFSLGIAMLELACYMDLPSNGPLWHELRHGILPEEFINKISLELQ Myt1_Spur LAPELLQGHFGMHADVYSLGITILELASDLELPRNGDSWHDLRQGRIPWQLTAGISSELK AqueK217_Aque MAPELMEGRFSPGADVFSLGISMLEVACDLQLPSNGESWHMLRRGELPEDFIKNLSPDLL MYT1_Mmus MAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELR : * ::* :*::*:*:::** :.:* * *. :*. :* : :* :* MYT1_Hsap SVLVMMLEPDPKLRATAEALLALPVLRQPRAWG---VLWCMAAEALSRG-WALWQALLAL wee-1.3_Cele SLIALMLDSDPRIRPTSRDLLDHPVIKKKLMKRGTYV---KCISILNGF-FYAFSAVLVW wee-1.1_Cele ELVKQMMDKAPTRRPTCSELMKNHVVKEKLRIRKQEVEHIPS-E--S------------- Myt1_Dmel SVIKSMMKPDPAQRPTAEQLLSHPKLQYLQKKRKSLMNFSMLSRSFRRSRRAVWGRMCNW Myt1_Spur GLIRSMMDPDFRKRPSLASLMETSLVQSTIAWQRR-------KRVLNKM-WNTFHGFLSL AqueK217_Aque SLLTSMMSHNPQSRPCVNQILGHQTPPTLGKPQSLGEPLSDSEDEDIRM-SLLQ------ MYT1_Mmus SVLAMMLEPDPQLRATAEALLALPMLRQPRPWN---VLWYMAAEALSRG-WALWQALVTL :: *:. *. :: MYT1_Hsap LCWLWHG---------LAHPASWLQPLG--------------PPATPP------------ wee-1.3_Cele VMAFFSV---------LFHPIVRFHAAIKDRQSEICAQFVNNQQHTPIQ--TPETS--KV wee-1.1_Cele ----------------QFQPISYLTT------------------ESPLG--SRE------ Myt1_Dmel KTAAFRYLLYFLEVLHLCKPITASQPNI------------NIVPSSPSSKGVPLVPQVEF Myt1_Spur LFSLMSA---------LVFKI--------------------------------------- AqueK217_Aque --QSIS-----------QHNGSWT-------------------NHSPICH---------- MYT1_Mmus LCWLWHG---------LVHPASWLQPPG--------------PPATPP------------ MYT1_Hsap --------------------------------------------GS-------------- wee-1.3_Cele YLESLTGVAVRQA--SQIVS---PFDFSDDENPPNA--QRRLFTGA-------------- wee-1.1_Cele ----------SSCSS---------IDFLDHF--ENA--EKK----T-------------- Myt1_Dmel QLVGSTPIANRDCYASDFLSGEDPLDLSNQ-GSPNVINSTPLNTNQGKSRLDLLKNNVDS Myt1_Spur ------------------------------------------------------------ AqueK217_Aque --------------------------------------QYPVYSGS-------------- MYT1_Mmus --------------------------------------------GS-------------- MYT1_Hsap -----------PPCSLLLDSSLS-----------------SNWDDDSLGPSL-SPE-AVL wee-1.3_Cele -----------VPCRLNFDNDQDDDEEQAT---------CSSSNSSAIEPQLDEPE-SPP wee-1.1_Cele ------------PFVSKLNFDLEDDED-------------------E-YEVF-SPPRTPV Myt1_Dmel MGRYVHVHDFESPCSALSSAKVLD-----TSSFRRKKLFVLEYDDEKKAPKK-KTE-VVF Myt1_Spur -------------------------------------------------------L-SPS AqueK217_Aque ------------PIPLHLDDSSAD----------------------E-ATPL-KPG-SPL MYT1_Mmus -----------PPCSPLLDSTLS-----------------SSWDNDSIGPSL-SPE-TVL MYT1_Hsap ARTV--GSTSTPRSRCT------------------------------------------- wee-1.3_Cele -RMN--DVIDKLGKRGTPRSARRN------LTFNRHRQVAASVAPKSSLNHYNHHTGSGD wee-1.1_Cele -KKS-------------------------------------------------------- Myt1_Dmel DNKKRIEFLSGFRKRKNERRSRAKADLERNLKNERKR-I--RQEVKDGFNHLK------- Myt1_Spur -R------------RFHSN----------------------------------------- AqueK217_Aque -------LTSSPA--TF------------------------------------------- MYT1_Mmus SRIT--RRTSTPRGRYI------------------------------------------- MYT1_Hsap ------------------------------------------------------------ wee-1.3_Cele GFSNNSLIPISDQERTEK---------------YLRMR---------------------- wee-1.1_Cele ------------------------------------------------------------ Myt1_Dmel ----KSFEPLRELTEEDKAEEAEQQQEETYEDDEVQVKIVELTTNDLAAKRNMLGANTAE Myt1_Spur ------------------------------------------------------------ AqueK217_Aque ------------------------------------------------------------ MYT1_Mmus ------------------------------------------------------------ MYT1_Hsap ---PRDALDLSD----INS----------------------------------------- wee-1.3_Cele --LTEQQLDWADQNNVIDEA-----PPPMSCPPRIRRSIRDLPRMPVLNFNVLDEPSNKP wee-1.1_Cele ----RYQQTM-------------------------------------------------- Myt1_Dmel ESEPEEQADQSE----EDEADQANRIPGMDFDPNARKQQKG-SRPPDEDQN-AEENAPEQ Myt1_Spur --MNAEAIDAPD----LKQR-----HPSSWDLS--------------------------- AqueK217_Aque ---PRADRAM-------------------------------------------------- MYT1_Mmus ---PRDALDLTD----VDS----------------------------------------- MYT1_Hsap ------------------------EPPRGS-----------FPSFE---PRNLLS-LFE- wee-1.3_Cele TVDHHTILE-------------QSESPRR-------RLNRGA-KPV---PRNRMM-SFG- wee-1.1_Cele ---------------------PE--------------------VSP---PRKIQK-LFQR Myt1_Dmel TVQAEGAPGQEEQPEEGQAGPQQHHQERSQASAQAAQVRKGQPDQIPKGSDGQQKGAAA- Myt1_Spur --------------------------------------------FS---D-GMLQ-IKQM AqueK217_Aque ---------------------RRVHSDR-----------------------GFVNG--G- MYT1_Mmus ------------------------EPPRGP-----------CPTFE---PRNLLS-LFE- MYT1_Hsap DTLDPT wee-1.3_Cele SSGDEV wee-1.1_Cele KNLFDE Myt1_Dmel QTECRL Myt1_Spur SVEMPL AqueK217_Aque PRNLME MYT1_Mmus DSLDPA