CLUSTAL W (1.83) multiple sequence alignment NEK1_Hsap MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH NEK5_Hsap MDKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKH NEK3_Hsap MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKS-FSNTQNSRKEAVLLAKMKH NEK1_Mmus MEKYVRLQKIGEGSFGKAVLVKSTEDGRHYVIKEINISRMSDKERQESRREVAVLANMKH NEK3_Mmus MDNYTVLRVIGQGSFGRALLVLQESSNQTFAMKEIRLLK---SDTQTSRKEAVLLAKMKH NEK5_Mmus MDNFHLIKIIGEGTFGKVYLAKDKSESSHCVIKEISLT----KEKEASKNEVILLARMEH Nek3_Ddis MDKYEEIKTIGKGSFGRAILVKRKSDGLLLVLKEINVMEMQPKERSDAMNEVNLLSMLDH AqueK176_Aque MDQYTRIRKIGEGSYGRALLVKGRQDGRQYVIKVINLSKMDRRGREEARREVKVLSQMKH GK072_Glam MEHYTVIRKIGEGSFGECFLCCDKRTGLHVVIKEISMEDMQDTEVRNTERESAILLTMDH GK270_Glam MERYKELKVLGKGSFGRAVLAQEKSTGIKYVMKVIHIAPLKPREREEALTEAKILSKLKH *: : :: :*:*::*. * . .:* * . : * :* :.* NEK1_Hsap PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQ--KGVLFQEDQILDWFVQICLALKH NEK5_Hsap PNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQ--RGVLFSEDQILGWFVQISLGLKH NEK3_Hsap PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQ--KGKLFPEDMILNWFTQMCLGVNH NEK1_Mmus PNIVQYKESFEENGSLYIVMDYCEGGDLFKRINAQ--KGALFQEDQILDWFVQICLALKH NEK3_Mmus PNIVAFKESFEAEGYLYIVMEYCDGGDLMQRIKQQ--KGKLFPEDTILNWFIQICLGVNH NEK5_Mmus PNIVTFFSSFQENGRLFIVMEYCDGGDLMQRIQRQ--RGVMFSEDQILCWFVQISLGLKH Nek3_Ddis ENIIGYYDSFILNGCLYIIMEYANAGDINLEIKKRTLQNKTFSEFEILSWFSQICKALQY AqueK176_Aque PNIVSYKDSFEETGSLYIVMDYCDGGDLYKHINAQ--RGRLFPEDQILNWFVQLCLALKH GK072_Glam PNIVRGIESFKEDGFLYIAMTYCEHGELTSLIKRHHKSQMHFEESQVLRWIAQLASALWY GK270_Glam PYIVGYHESFADTRYLHIVMEYADAGDLTDAIKRQKMKNSLFPEDQIWDWFVQICMALKH *: .** *.* * *.: *:: *: : * * : *: *:. .: : NEK1_Hsap VHDRKILHRDIKSQNIFLTK-D------GT-VQLGDFGIARVLNSTVELARTCIGTPYYL NEK5_Hsap IHDRKILHRDIKAQNIFLSK-N------GMVAKLGDFGIARVLNNSMELARTCIGTPYYL NEK3_Hsap IHKKRVLHRDIKSKNIFLTQ-N------GK-VKLGDFGSARLLSNPMAFACTYVGTPYYV NEK1_Mmus VHDRKILHRDIKSQNIFLTK-D------GT-VQLGDFGIARVLNSTVELARTCIGTPYYL NEK3_Mmus IHKRRVLHRDIKSKNVFLTH-N------GK-VKLGDFGSARLLSSPMAFACTYVGTPYYV NEK5_Mmus IHDRKILHRDIKSQNIFLSK-N------GMVAKLGDFGTARTLNDSMELAQTCAGTPYYL Nek3_Ddis ISSRNILHRDLKTQNIFLSIVNG----DYF-IKLGDFGIAKILNSETSLASTVLGTPYYL AqueK176_Aque VHDRKILHRDIKSQNVFLTK-R------GV-VKLGDFGIARVLNSTVELARTCIGTPYYL GK072_Glam IHSKGLIHRDLKSQNIFLDQ-D------LN-VHIGDFGIARTINP-GSMASTFIGSPLYM GK270_Glam VHDRKILHRDLKTQNIFLCT-DENDRSRKT-VKLGDFGIAKILQSTLECARTAIGTPYYL : .: ::***:*::*:** ::**** *: :. * * *:* *: NEK1_Hsap SPEICEN-KPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSY NEK5_Hsap SPEICQN-KPYNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSR NEK3_Hsap PPEIWEN-LPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSY NEK1_Mmus SPEICEN-KPYNNKSDIWALGCVLYELCTLKHAFEAGNMKNLVLKIISGSFPPVSPHYSY NEK3_Mmus PPEIWEN-LPYNNKSDIWSLGCILYELCALKHPFQANSWKNLILKICQGPIHPLPALYSC NEK5_Mmus SPEICQN-RPYNNKTDIWSLGCVLYELCTLKHPFESNNFHHLVLKICQGRVAPISPHFSR Nek3_Ddis SPELIQNEKGYDHKSDIWSLGCVLYELTTLKHAFNAANLPALVLKILKGTYPPIPSHYSN AqueK176_Aque SPEICEN-RPYNNKSDIWALGCVLYEMATLRHAFEAGNMRNLIVKIVRGSYPPLSSQYSR GK072_Glam SPELIQG-TSYNSQSDMWSLGCMIFEILCLKTAFQAKNINTLIMKIVSGKVPELPGIYSS GK270_Glam SPELCED-KPYNNKSDIWSLGCVLYEICTLQHAFEAQNMKGLVVKILRGQYQPISNTYSR .**: :. *: ::*:*:***:::*: *: .*:. . *::*: . :. :* NEK1_Hsap DLRSLVSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLI--AEEF-CLKTFSKFGSQ NEK5_Hsap ELHSLISQLFQVSPRDRPSINSILKRPFLENLIPKYLTPEVI--QEEF-SHMLICRAGA- NEK3_Hsap ELQFLVKQMFKRNPSHRPSATTLLSRGIVARLVQKCLPPEII--MEY------------- NEK1_Mmus DLRSLLSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLI--AEEF-CLKTLSKFGPQ NEK3_Mmus KLQGLVKQMLKRNPSHRPSATTLLCRGSLAPLVPKCLPPQII--REY------------- NEK5_Mmus DLQSLIPQLFRVSPQDRPSVTSLLKRPFLETLIARSLYPEVC--SRRIQSHAHMENMAI- Nek3_Ddis DLRNLISSMLQIDPKNRPSVNDILELPFINQYLGIPLKPFDSNLNENN-NDS-LNISNNS AqueK176_Aque NLRSLVDSCLKNAPRDRPSINSILRLPFIQERIGKLLSETVS--AEEF-SHTVLHKKKTE GK072_Glam KLRDICLNLLNQVPDQRMTAAQLCGHDLIAPFIFELNLPHP----ESFD----------- GK270_Glam NLREVLDRMLQKDPNKRPSVNQILKLPFLQERIRRLLPEDYW--NEEF-SHTIIHGRGNA .*: : :. * .* : : : : . NEK1_Hsap PI---------PAKRPASGQN---SISVMPAQKITKPAAKYGIPLAYKKYGDKKLHEKKP NEK5_Hsap ------------------------------------PASRHAGKVVQK---------CKI NEK3_Hsap --------------------------------------------------GEEVLEEIKN NEK1_Mmus PL---------PGKRPASGQG---VSSFVPAQKITKPAAKYGVPLTYKKYGDKKLLEKKP NEK3_Mmus --------------------------------------------------GEQILDEIKI NEK5_Mmus ------------------------------------------------------------ Nek3_Ddis -----------SG---------SNNS---------------A------------------ AqueK176_Aque PV---------PKPLPLKKE---------PPQIV--EGVKIGLKAQGGVGGDKKVDERRV GK072_Glam -----------------------------PPT------AA-------------------- GK270_Glam LVGFGAGRVGIPGK-PVSGVPPKDDASSEASSAGRQPASRHGPPSAHPP--------PPP NEK1_Hsap LQK-HKQAHQTPEKRVNTGEERRKI----------SEEAA-RKRRLEFIEKEKKQK---- NEK5_Hsap QKV-RFQGKCPPRSRISVPIKRNAIL--HRNEWRPPAGAQ-KARSIKMIERPKIA----- NEK3_Hsap SK------HNTPRKKTNPSRIRIAL----------GNEAS-TVQE-E------------- NEK1_Mmus PPK-HKQAHQIPVKKMNSGEERKKM----------SEEAA-KKRRLEFIEKEKKQK---- NEK3_Mmus ST------PKNMK-KQDSNRVRRAL----------GEANSASMQE-E------------- NEK5_Mmus -------------------------G--PTACWR-------------------------- Nek3_Ddis ---------------------SNN----------ISSS-----------TEVKDQK---- AqueK176_Aque SAEERRRVVLKPKQRMSEGGKKPSPGLLAK--KKELEEKA-RAQREE-INQQRKSE---- GK072_Glam ------------------------V----------GNAFASRLSK-S------------- GK270_Glam SQQ-NKPMYFNPNGGYQPPAANQK----------LSAAEV-AAMAIKNNQRPPPPVNQYQ NEK1_Hsap -----------------------DQIISLMKAEQMKRQEKERLERI-------------- NEK5_Hsap ------------------------------------------------------------ NEK3_Hsap ------------------------------------------------------------ NEK1_Mmus -----------------------DQI-RFLKAEQMKRQEKQRLERI-------------- NEK3_Mmus ------------------------------------------------------------ NEK5_Mmus ------------------------------------------------------------ Nek3_Ddis -----------------------FQNIPLAMARNINNNNNNNNNNNNNNNNNNNNNNNNN AqueK176_Aque -----------------------AQ---MKLHQQLKKQELLR------------------ GK072_Glam ------------------------------------------------------------ GK270_Glam SNVKQPGIMPGAIAVGVPGAPPVVQVNNKLSYDEIVRQEKQRIEEQ-------------- NEK1_Hsap ------------------------------------------------------------ NEK5_Hsap ------------------------------------------------------------ NEK3_Hsap ------------------------------------------------------------ NEK1_Mmus ------------------------------------------------------------ NEK3_Mmus ------------------------------------------------------------ NEK5_Mmus ------------------------------------------------------------ Nek3_Ddis NNNNNNNNNNNNNNNKSNVDDVNSSSTTTTSSSIVKSKVNTTVSPPLSPKKPITTTTTKT AqueK176_Aque ------------------------------------------------------------ GK072_Glam ------------------------------------------------------------ GK270_Glam ------------------------------------------------------------ NEK1_Hsap ------------------------------------------------------------ NEK5_Hsap ------------------------------------------------------------ NEK3_Hsap ------------------------------------------------------------ NEK1_Mmus ------------------------------------------------------------ NEK3_Mmus ------------------------------------------------------------ NEK5_Mmus ------------------------------------------------------------ Nek3_Ddis TSLKTTPSIKPTLVKTPTIKSSLVKTPLSKTPISGTKNPTTSKITPSIKTPLPKAPISSK AqueK176_Aque ------------------------------------------------------------ GK072_Glam ------------------------------------------------------------ GK270_Glam ------------------------------------------------------------ NEK1_Hsap -----------NRAREQG-WR-NVLSAGGSGEVKAPFLGSGGTIAPSSFSSRGQYEHYHA NEK5_Hsap -------------------------------------------------AVCGHYDYYYA NEK3_Hsap ------------------------------------------------------------ NEK1_Mmus -----------NRAREQG-WR-NVLRAGGSGEVKASFFGIGGAVSPSPCSPRGQYEHYHA NEK3_Mmus ------------------------------------------------------------ NEK5_Mmus ------------------------------------------------------------ Nek3_Ddis TPTRLVSKPTTPKITTPKSTSTMI------------------------TPKRTTTTTTTP AqueK176_Aque -------------RQQD-QQR-AVINW-------------QANISP------------HS GK072_Glam ------------------------------------------------------------ GK270_Glam -----------RRRYQEDQAR-AQ------------------------EKVRQDYIKYHA NEK1_Hsap IFDQMQQQRAEDNEAKWKREIYGRGLPERGILPGVRPGFPYGAAGHHHFPDADDIRKTLK NEK5_Hsap QLDMLRR-RAHK--------------------PSYHP-IPQENTG--------------- NEK3_Hsap ------------------------------------------------------------ NEK1_Mmus IFDQMQRLRAEDNEARWKGGIYGRWLPERGVPPGVRPGFPSEASGHYHSPDAGAIRKTLK NEK3_Mmus ------------------------------------------------------------ NEK5_Mmus ------------------------------------------------------------ Nek3_Ddis TP---------------------------------------------------------- AqueK176_Aque STDE-------------------------------------------------------- GK072_Glam ------------------------------------------------------------ GK270_Glam AQQENRGYHAV----------QGNPFAK------KQAQQASGAPGAGHAPSADMLDAKFA NEK1_Hsap RLKAVSKQANAN-RQKGQLAVERAKQVEEFLQRKREAMQNKARAEGHMGILQNLA---AM NEK5_Hsap ----VEDYGQET-RH----GPSPSQWPAEYLQRKFEAQQYKLKVEKQLGL---------- NEK3_Hsap ------------------------------------------------------------ NEK1_Mmus RLKAVSKQASTN-RQKGHLAVERANQVEEFLQRKREAMQNKARAEGH-GLLQNLA---SL NEK3_Mmus ------------------------------------------------------------ NEK5_Mmus ----------------------VSPWSAAYLQRKFEAQQYKLKVERQLGL---------- Nek3_Ddis -------------------------------------TTA-------------------- AqueK176_Aque ----SSHQAKSETADEEPVKVDRQQIVSDFHQVRQEAAANKARAQAQLMGGANLGVGVAK GK072_Glam ----ISDQAISE-AD----IFSNTSKINIYIKQGVEAENNAIQSIRQGG----------- GK270_Glam DL-------------------------QDFINRPVAAQQP-------------------- NEK1_Hsap YGGRPSSSR------------GGKPR---------------N-KEEE-VYLARLRQIRLQ NEK5_Hsap ---RPSSAEPNYNQRQELRSNGEEPRF----QELPFR---KNEMKEQ-EYWKQLEEIRQQ NEK3_Hsap ------------------------------------------------------EQDRKG NEK1_Mmus YGGRPSSSR------------GGKPR---------------N-NEEEVVYLARLRQIRLQ NEK3_Mmus ------------------------------------------------------ERGRKC NEK5_Mmus ---RPSSVEPHPNEGEKLQSHWEETKF----QELQYR---KNKMKDQ-EYWKQLEEIRQQ Nek3_Ddis ----------TTTPKKSSLSSSSSSSVKPPPPTTTTTTPSKDR----------------- AqueK176_Aque QGGVVKPVE-------------NKPP---------------N-NAEQ-EYLARLEDIRRQ GK072_Glam --ASPTYSTG-----RRMT----------------------------------------- GK270_Glam ----------QPSRQSQAPSISQSPTRQQQQQQQQQQ---QQQ----------------- NEK1_Hsap NFNERQQIKAKLRGEKKEANHSEGQEGSEEADMRRKKIESLKAHANARAAVLKEQLERKR NEK5_Hsap YHNDMKEIRKKMGREPEENSK-----ISHK--TYLVKKSNLPVHQDASEGEAPVQMEF-- NEK3_Hsap SHTDLESI---------------------------------------------------- NEK1_Mmus NFNERQQIKAKLRGENKEADGTKGQEATEETDMRLKKMESLKAQTNARAAVLKEQLERKR NEK3_Mmus SHTELEST---------------------------------------------------- NEK5_Mmus YHNDMKEIKKKMGRELKRV----------------------------------------- Nek3_Ddis --SSVNTINKPMASNLS------------------------------------------- AqueK176_Aque NFQERKRVQERVSMYCHGNQAPPIPIPKVNPEARRKKIAALKAQAESESVKLREQVELKQ GK072_Glam ------------------------------------------------------------ GK270_Glam --QRDQAIRRNIEE---------------------------------------------- NEK1_Hsap KEAYEREKKVWEEHLVAKGVKSSDVSPPLGQHETGGSPSKQQ-MRSVISVTSALK----- NEK5_Hsap ---------------------------------RSCCPGWSAMARSWLTATSASQDIEKD NEK3_Hsap ----------------------------------NENLVESAL----------------- NEK1_Mmus KEAYEREKKVWEEHLVA-RVKSSDVPLPLELLETGGSPSKQQ-VKPVISVTSALK----- NEK3_Mmus ----------------------------------GTTPAGNAL----------------- NEK5_Mmus ------------------------------------------------------------ Nek3_Ddis ------------------------------------------------------------ AqueK176_Aque KQRAA------------------------------------------------------- GK072_Glam ------------------------------------------------------------ GK270_Glam ------------------------------------------------------------ NEK1_Hsap ---------------------------EVGVDSSLTDT--RETSEEMQKTNNAISSKREI NEK5_Hsap LKQMRLQNTKESKNPEQKYKAKKGVKFEINLDKCISDENILQEEEAMDIPNETLTFED-- NEK3_Hsap ------------------------------------------------------------ NEK1_Mmus ---------------------------EVGLDGSLTDT--Q--EEEMEKSNSAISSKREI NEK3_Mmus ------------------------------------------------------------ NEK5_Mmus ------------------------VKFEISLDKCISEEDTVQENEAVDKLNATLSFED-- Nek3_Ddis ------------------------------------------------------------ AqueK176_Aque ------------------------------------------------------------ GK072_Glam ------------------------------------------------------------ GK270_Glam ------------------------------------------------------------ NEK1_Hsap LRRLNENLKAQEDEKGKQN---LSDTFEINV-HEDAKEHE-----KEKSVSSDRKKWEAG NEK5_Hsap ------GMKFKEYECVKEHGDYTDKAFEKLH-CPEAGFST-----QTVAAVGNRRQWDGG NEK3_Hsap -R----------------------RVNREEK-GNKSVHLR-----KASSPNLHRRQWEKN NEK1_Mmus LRRLNENLKAQEDEKEKQH---HSGSCETVG-HKDEREYE-----TENAISSDRKKWEMG NEK3_Mmus -E----------------------RAARGNP-GNPQEHGR-----HTSPASPHRPWWERH NEK5_Mmus ------GTKFQEHRCKEEHEDYTDRAFEELC-GPEAEGFF-----QDVIAAENRRQWDAG Nek3_Ddis ---------SQISSSSSSS---SSSNSQFRPTTPSKERMSPTSTSTKSPTNPS---PTLS AqueK176_Aque --------------------L-------------------------HSNVSPPRKQWVVP GK072_Glam ----------------------------------------------------------G- GK270_Glam -------------------------------QRRHQQEVK-----RQLAPAPL---KEQA NEK1_Hsap -GQL-VIP-LDE--LTLDTSFS-TTER----------------------HTVGEVIKLGP NEK5_Hsap -APQTLLQMMAV--ADITSTCP-TGPD------------------------NGQVIVIEG NEK3_Hsap -VPNTALTALEN--ASILTSSL-TAED----------------------DRGGSVIKYSK NEK1_Mmus -GQL-VIP-LDA--VTLDTSFS-ATEK----------------------HTVGEVIKLDS NEK3_Mmus -GPSSNVEALEK--ASILTSSF-TAED----------------------DRGGSVIKYEE NEK5_Mmus -APHTLLRIMAM--ADVTSTCP-TMPD------------------------DGQVIVMEG Nek3_Ddis -SSSS---LPKS--SLKSDSLCTSPPRFSNTTGSSGGIGVSGNGNSNVNSTVLNRSVS-S AqueK176_Aque DMPPSLAE--------GDATSA-TVNE----------------------KTTSDVV-FE- GK072_Glam DIPESASSAFKYNSDPILSHIF-------------------------------------- GK270_Glam -KDARERELMEA--HNKVQRQK---------------------------EEQERRIRE-A NEK1_Hsap NGSPRRAWGKS-------------PTDSVL------------------KILGE---AELQ NEK5_Hsap IPGNRKQWRHE-------------APGTLM------------------SVLAA---AHLT NEK3_Hsap N-TTRKQWLKE-------------TPDTLL------------------NILKN---ADLS NEK1_Mmus NGSPRKVWGKN-------------PTDSVL------------------KILGE---AELQ NEK3_Mmus N--ARRQWVRE-------------PPEALL------------------SMLKD---ADLS NEK5_Mmus SVENGKQWWLD-------------VPGTPC------------------ALAAE---CACS Nek3_Ddis LSIQHKPTNSGSSSISSSSSGNNSNSNTTTNNNTTSTTPIRPGLKSTKSMLELSTPTSIS AqueK176_Aque RPKPRPAWGVA-------------DTPLEI------------------PAMPT---QDIS GK072_Glam ---------------------------SQL------------------VLLVD---HDST GK270_Glam KEKQRAEWEKR-------------NREYEK------------------QMEEK---RKAA NEK1_Hsap LQ-----------------TELL--EN----TTIRSEISPEGEKYKPLITGEKKVQCISH NEK5_Hsap SS-----------------S--F--SA----D-------------EE------------- NEK3_Hsap LA-----------------FQTY--TI-----------------YRP------------- NEK1_Mmus LQ-----------------TELL--EN----TSFKSEVYAEEENYKPLLTEEENLQCISK NEK3_Mmus QA-----------------FQTY--TI-----------------YRP------------- NEK5_Mmus -G-----------------S--L--SA----S-------------K-------------- Nek3_Ddis TSNKSTTTTPTSSRSNTPSTGRLSLTT-----S----------IPRP------------- AqueK176_Aque IC-----------------PEET--AILFENKSRPPKEDAGEIGKTRVISLE-------- GK072_Glam VA-----------------SQLV--SI-----------------VRL------------- GK270_Glam QA-----------------AEDR--EK----ER----------LFRI------------- NEK1_Hsap EINPSAIVDSPVETKSPEFSEASPQMSLKLEGNLEEPDDLETEILQEPS---GTNKDESL NEK5_Hsap -------------------------FA---MGTLKQWLPKEED----------------- NEK3_Hsap -------------------------GS---EGFLKGPLSEETEA---------------- NEK1_Mmus EINPSATVDS-TETKSPKFTEVSPQMS---EGNVEEPDDLETEVLQEPS---STHTDGSL NEK3_Mmus -------------------------GA---EGFLKGPLSEDT-A---------------- NEK5_Mmus -------------------------GE---TVMIKPQLPKE-D----------------- Nek3_Ddis ------------------------PS---SNGSNTGSSSSTTTTPTK-ISTTSSSS---- AqueK176_Aque ---------------SHHYS------N---EGERQRSPGEEEKGD----DKT----DG-- GK072_Glam -----------------------------------------TYS---------------- GK270_Glam ------------------------S---------NGPANAGSEA-----NPSKGGMESLL NEK1_Hsap PCTITDV--------WISEEKETKETQSADRITIQENEVSEDGVSSTVDQLSDIHIEPGT NEK5_Hsap --------------------------------------------EGKVE----------- NEK3_Hsap --------------------------------------------SDSVDG---------- NEK1_Mmus PPVLNDV--------WTREKEAAKETELEDKVAVQQSEVCEDRIPGNVDQSCKDQRDPAV NEK3_Mmus --------------------------------------------SDSVDG---------- NEK5_Mmus --------------------------------------------QEKVE----------- Nek3_Ddis -------SLNKLTTPIK-------------------SSTTTSTTAST------------- AqueK176_Aque -----GT--------WINEVELAKPQPLTSR----ENIVCNDE------GSIGKERSVVS GK072_Glam --------------------------------------------FQDVD----------- GK270_Glam PPKIMDPGVQNRNDPRNHEERTEQQRKLEEQRDAMRRMIAERRREQE------------- NEK1_Hsap NDSQHSKCDVDKSVQPEPFFHKVVHSEHLNL---VPQ-----VQSVQCSPEESFAFRSHS NEK5_Hsap ------------------------------------------------------------ NEK3_Hsap ------------------------------------------------------------ NEK1_Mmus DDSPQSGCDVEKSVQPESIFQKVVHSKDLNL-----------VQAVHCSPEEPIPIRSHS NEK3_Mmus ------------------------------------------------------------ NEK5_Mmus ------------------------------------------------------------ Nek3_Ddis -----NSQTIKKSITPIKVTSQQVDSTISNI---KNN----IVIGNSVSTKTNISVISHL AqueK176_Aque LNVEE---EGEGVRMKEPLFDKVLKDREEKSIKSLPQAEETIVSDIECEEEEELEEEQGK GK072_Glam ------------------------------------------------------------ GK270_Glam -----LK-RGEQ----------RAQPPVDEI---K------------------------- NEK1_Hsap HL-----------PPKNKNKNSLLIGLSTGLFDANNPKM---LRTCSLPDLSKLFRTLMD NEK5_Hsap ------------------------------------------------------------ NEK3_Hsap ------------------------------------------------------------ NEK1_Mmus DS-----------PPKTKSKNSLLIGLSTGLFDANNPKM---LRTCSLPDLSKLFRTLMD NEK3_Mmus ------------------------------------------------------------ NEK5_Mmus ------------------------------------------------------------ Nek3_Ddis SP-----------SIKPLPTQSIITQLPTSASTASTASTTNTTLTSGTNTMTTKKRTDFK AqueK176_Aque EKEREEDEVEDEESEEIFEPDGLSRSLKSGHYDTN-YTI---LRTCSLPDLRLTTP-TIK GK072_Glam --------------------------------------M---LRDITLLDIPPHFNDIYK GK270_Glam ------------------------------------------------ENLSAKGRRLCD NEK1_Hsap VPTVGDV-RQDNLEIDEIEDENIKE-GPSDSEDIV----FEE------------------ NEK5_Hsap --------MVSGIEV---DEEQL-E-PRSDDDDTN----FEE------------------ NEK3_Hsap --------GHDSVIL---DPERL-E-PGLDEEDTD----FEE------------------ NEK1_Mmus VPTVGDV-HQDSLEIDELEDEPIKE-GPSDSEDTV----FEE------------------ NEK3_Mmus --------DLDSVML---DPERF-E-PRLDEEDTD----FEE------------------ NEK5_Mmus --------IATGIMV---DDEQL-E-PGSDEDDIK----FEE------------------ Nek3_Ddis LDDLGHRSKLNSVKLSSKSSSPIKT-SSSSSSSS----SSSS------------------ AqueK176_Aque VELTTPT-NQSQIPCT-RSDVNIKEAAPAQKEDTDT--VFDTPLSSSIDLDTPTSVADIA GK072_Glam S----------------------KT-AWTDNSCTT----WDR------------------ GK270_Glam VPSV-----------QEPAVQPT-----GQTDDKNALACLDE------------------ . . . NEK1_Hsap ----------TDTDLQ-------ELQASMEQLLRE--QPGEEYS--EEEESVLKNSDVEP NEK5_Hsap ----------SEDELR------DEVVEYLEKLA-T--FKGEEKT--EEASSTSKDSRKSR NEK3_Hsap ----------EDDN-P------D-WVSELKKRA-G--W---------------------- NEK1_Mmus ----------TDTDLQ-------ELQASMEQLLRE--QPGDEYS--EEEESVLKSSDVEQ NEK3_Mmus ----------DNEN-P------D-WVSELKKHV-G--YG--------------------- NEK5_Mmus ----------SEDELR------SEIIESLEKLA-A--ST--EEA--EQAPSSSKNAEEPG Nek3_Ddis ----------SITDKK-------SINRVKLNNLKE--KNKEIINNIKISSTIPKPSNINS AqueK176_Aque TPNDTESGSSSLTDVEDNDRGYEEMIKTLRDLYNKGGTPSPK--PVSHNTSTPNPGHIST GK072_Glam ------------------------------------------------------------ GK270_Glam ----------KDS-----------------------------------------DSDFED NEK1_Hsap TA---------------------------------NGTDVADEDDNPSSESALNEEWHSD NEK5_Hsap ER---------------------------------EGIS--------------------- NEK3_Hsap ------------------------------------------------------------ NEK1_Mmus TA---------------------------------RGTDAPDEEDNPSSESALNEEWHSD NEK3_Mmus -----------------------------------------------------------D NEK5_Mmus EK---------------------------------EKT---------------------- Nek3_Ddis SSSSAFSDLNSSGSSSLNNSLTSSSSSIITNQNNQNNQNNQNNQNNQNNLKIINELILQN AqueK176_Aque TENE-------------------------------EGTEREEE-EGACHCSLVEEDWESS GK072_Glam ------------------------------------------------------------ GK270_Glam PY---------------------------------FNPNAPDGNGGPG---SLDKAEKAA NEK1_Hsap NSDGEIA----------SECEC-DSVFNHLEELRLHLEQEMGFEKFFEV-YEKIKAIHED NEK5_Hsap --------------------------MQKSEELREGLEN------ISTTSNDHICITDED NEK3_Hsap ------------------------------------------------------------ NEK1_Mmus NSDAETT----------SECEY-DSVFNHLEELRLHLEQEMGFEKFFEV-YEKVKAIHED NEK3_Mmus GP---------------------------------------------------------- NEK5_Mmus ------------------------------------------------------------ Nek3_Ddis NLNNSIS----------KENLDDKRLHSRANALRHFCSSIFGEDKFKET-YNLLKSQSPS AqueK176_Aque DDEFTDGSDGVDRCGSSNKGEGQGRIFDKLEETRNRLEEKLGLDNLLEA-YTVVKEFQDR GK072_Glam ------------------------------------------------------------ GK270_Glam NMMKMLR----------AETTE-ESISQRMERLRILLEGELGLTNFVKA-YQYIRTNTEQ NEK1_Hsap E-DENIEICS------------KIVQNILGNEHQHLYAKILHLVMADGAY---------- NEK5_Hsap Q-GT-------------------------------------------STT---------- NEK3_Hsap -------------------------------------------------Q---------- NEK1_Mmus E-DENIEICS------------TIVENILGNEHQHLYAKILHLVMADGAY---------- NEK3_Mmus -----------------------------------------------GGQ---------- NEK5_Mmus ------------------------------------------------NL---------- Nek3_Ddis T-SNN-EIVDIASI-------ENQLSQLIGDKIY-YLKYLQQLIYC-------------- AqueK176_Aque ECDEDTNVLSSDTVTAQDGFPLATLTSIIGEEHSHCFPSLIHLVISDSAYFELNAQSTNQ GK072_Glam ----ETELLS------------WIFERIAGEKGDACLGLCRLLVSA-------------- GK270_Glam G-GED-DLNQ------------NVIVGIIGETNVGFINTIVSLIYCEDR----------- NEK1_Hsap -------------QEDNDE NEK5_Hsap -------------SQNIQV NEK3_Hsap --------------GLCDR NEK1_Mmus -------------QEDNDE NEK3_Mmus -------------LLGERA NEK5_Mmus -------------PVKKLQ Nek3_Ddis ---------------ESQI AqueK176_Aque KSSSETLLSMATGSLVLES GK072_Glam ---------------DDYS GK270_Glam --------------FNTVR