CLUSTAL W (1.83) multiple sequence alignment NEK10_Hsap MPDQDKKVKTTEKSTDKQQ-EITIRDYSDL--KRLRCLLNVQSSKQQLPAINFDSAQNSM NEK10_Mmus MPDQDTKAKSTEKTADKQQ-GTTTRDYSDL--KRLRCLLNVQSSKQQLPAINFDSAQNNM pqn-25_Cele MTEEVG---------QKLLESLSLFKLGDIGYARIECELLTTFLEEQLE----------- NEK10_Spur MPSGDKKHRHTDVKRDKE-----------L--DKLLRLLSTPSNKQQLPPLDFDAGNNNN AqueK177_Aque MSH--------------------------------------------------------- *. NEK10_Hsap TKSEPAIRAGGHRA---------------RGQWHESTEAVELENFSINYKNERNFSKHPQ NEK10_Mmus TKSEPTIRTGGHRA---------------RGQWHESTEAVELENFSINYKNERNFSKHPQ pqn-25_Cele ----------------------------------------------------NNLD---- NEK10_Spur NNNSPDGKGFHHGSSTTVGLHCSPPNGNGYSHQHQIFEASALESFSSKYQTERNFSGHVF AqueK177_Aque ------------------------------------------------------------ NEK10_Hsap RKLFQEIFTALVKNRLISREWVNRAPSIHFLRV-LICLRLLMRDPCYQE-ILHSLGGIEN NEK10_Mmus HQLFQEIFTALVRNRLICREWVNRAPSIHFLRV-LICLRLLMRDPCYQE-ILHKLGGIED pqn-25_Cele SLSIHELSTNLIRNRICCREFIESRPAKKWVFLIFRLARTLFRDKTRIA-TFHSVNLHSE NEK10_Spur NKQFDQIFTAIVKHRLCCSEWVERVPTEHIVRV-LIVLRLFLRDQSYQK-TLFELGGVKV AqueK177_Aque ---------------LSSSSWAATSEGDK-LI-LFSCLRLLMRDGVLLGKFISNSSSLVV : . .: : : : * ::** : . . NEK10_Hsap L----A---------------QYMEIVANEYLGYGEE-QHTVDKLVNMTYIFQKLAAVKD NEK10_Mmus L----A---------------QYMEIVANEYLGYAEE-QHCVDKLVNMTYIFQKLAAVKD pqn-25_Cele FVQVFWRNLTYQTKSYRNCKFQTFQFIASRFLRS-EH-DWNV-TVVNCLNVTQKLIDNGE NEK10_Spur L----S---------------QKLLTATENYLNRGDSEPFMVDILKEMSNIFQKLSGNVK AqueK177_Aque L----L---------------QELQSATHSYLSSTDK-DSS--LIIELTNIVQKLSHTHS : * : : :* : : : : *** . NEK10_Hsap QREWVTTSGAHKTLVNLLGARDTNVLLGSLLALASLAE-SQECREKISELNIVENLLMIL NEK10_Mmus QREWVTASGAHKTLVSLLGARDTTVLLGALLALASLAE-SSECREKISELNVVENLLMIL pqn-25_Cele NARKFVDCNLEDAVLVLLATRQMTVLQHSLEILGRLSDWSTTCRENL------------- NEK10_Spur QRDWLIACGAHRPLVMLLSASDVMVLHCSLYALIGMAQ-SPEPRAIIGELYCVETLLRIL AqueK177_Aque SHSALIDWESHKQLLFLLSAHSTHLLQSSINSLVNLGK-KQQGRKAILDCYPIDSLLHIL . . . :: **.: . :* :: * :.. . * : NEK10_Hsap HEYDLLSKRL---TAELLRLLCAEPQVKEQVKLYEGIPVLLSLLHSDHLK--LLWSIVWI NEK10_Mmus HEYDLLSKRL---TAELLRLLCAEPQIKEQVKLYEGIPILLSLLHSDHLK--LLWSVIWI pqn-25_Cele ---------L---CISLLRILSCEEQAREQIRIYDGVPTLLGLLSIKNSR--LQWHVAWT NEK10_Spur QDYDILSKKL---AAWLLKVLCLEEQVGEQVKIFDGMPILLSILHSDNIS--LLCDVVWC AqueK177_Aque DTNGANNKEIQNPVSDLLLLLSQEGAMRQQAKEQDLLSTCLSLLQFTTLGSYVKGRLLEM : ** :*. * :* : : :. *.:* : : NEK10_Hsap LVQVCEDPETSVEIRIWGGIKQLLHILQGDRNFVSDHSSIGSLSSANAAGRIQQLHLSED NEK10_Mmus LVQVCEDPETSVEIRIWGGIKQLLHILQGDRNFVSDRSSIGSLSSANAAGRIQQLHLSED pqn-25_Cele LAQLAEQHETSLEIAQLGGISLIFAAISN-P----------------------------- NEK10_Spur IAQLAQDQDASNDVRSMGGIPLLLALLH-DREFSSDRGSSHALASAGSSGRHHSLPFPVH AqueK177_Aque LDWVIDDEELTDEFRELGGIPVILILIS-P----------------------QSLCLKES : : :: : : :. *** :: : NEK10_Hsap LSPREIQENTFSLQAACCAALTELVLNDTNAHQVVQENGVYTIAKLILPNKQKNAAKS-- NEK10_Mmus LSPGEIEENTVSLQAACCAALTELALNDTNAHQVVQENGVYTIAKLILPNKQSNAAQT-- pqn-25_Cele KPPGKAVGDWVAMLTGLTALLAQLAQASSNQQLMSNANGVYILGKLLAIKKNVTTDETID NEK10_Spur DNGDVQLEHILSLKSACCAALTELVRNDTNAQQIVQNNGIYSVGMLIFPQKTSTKAES-E AqueK177_Aque -------LDDARILKASLSLLTRLSLNDMNAKQIIESNGLYLISHYLVQI---------E . : . : *:.* . * : : : **:* :. : NEK10_Hsap --NLLQCYAFRALRFLFSMERNRPLFKRLFPTDLFEIFIDIGHYVRDISAYEELVSKLNL NEK10_Mmus --NLLQCYAFRTLRFLFSMERNRPLFKRLFPTDLFETFIDIGHYVRDIGAYKDLVSQLNL pqn-25_Cele SWDLLQCSIFRVLRLMYTFERSRQLLKKVLPTEIFEKFVDVGNYNSVLTDYDQIAKMYDN NEK10_Spur AVQTLQKNSFRSLRFLFSMERNRRLFKRLFPPGLFEKFIDVGHYQRDISAYKSLVEMLSA AqueK177_Aque GDHELKLYCLRAMRYLFSLERNRRFLKIFFPLPIFEKFISIGHYVHNLSAYSDLAQSLSE . *: :* :* ::::**.* ::* .:* :** *:.:*:* : *..:.. . NEK10_Hsap LVEDELKQIAENIESINQNKAPLKYIGNYAILDHLGSGAFGCVYKVRKHSG------QNL NEK10_Mmus LLEDELKQIAENIESINQKKAPLKYIGDYAVLDHLGSGAFGCVYKVRKRSG------QNL pqn-25_Cele LIEENI-EIMKDWETVNERRQAVGEVGEYELLDQLGAGAFGCVYTVRKKAQSHSENPAKL NEK10_Spur LPADLLDTIKVNFEETNQNKEPTQSISGYLVYEHLGTGAFGSVYKVKKNAG------GNF AqueK177_Aque LSDDEKLALTTNQKSLNHTNCPLRVIGEYEVLELLGTGAYGSVYKVRKGPPR----GSNF * : : : : *. . . :. * : : **:**:*.**.*:* . :: NEK10_Hsap LAMKEVNLHNPAFG--KDKKDRDSSVRNIVSELTIIKEQLYHPNIVRYYKTFLEN--DRL NEK10_Mmus LAMKEVNLHNPAFG--KDKKDRDSSVKNIVSELTIIKEQLYHPNVVRYYKTFLEN--DRL pqn-25_Cele LALKEIFMTNL------NDRESDKSFGDMISEVKIIKQQLRHPNIVRYRRIFVEN--HRL NEK10_Spur LALKEISFNNPAVG--RTAKEKEKSIESIISELSIVKEHMRHPNVVRYYRTFTEPQVEKM AqueK177_Aque YALKEIQMTHPSLAGCSSLEERNGSIGKIMSEVSMIHKKLRHPNIVQYFKCFEES--HHL *:**: : : .: : *. .::**:.:::::: ***:*:* : * * .:: NEK10_Hsap YIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNN NEK10_Mmus YIVMELIEGAPLGEHFNSLKEKHHHFSEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNN pqn-25_Cele YIVMDLIQGCSLRDLIITMKEKKGNFEEKKIWAMVVQMMLALRYLHKEKQIVHRDLKPNN NEK10_Spur YIIMELIEGAPLYEHFNSLKEKNENFSEERIWHIFIQIVLALRYLHKEKKIVHRDLTPNN AqueK177_Aque YIEMSLIEGTPLSEFISSMKEKKTFFSEKRIWTIFSQMIRALRYIHEDKGITHRDLKPAN ** *.**:* .* : : ::***: * *:::* :. *: ****:*::* *.****.* * NEK10_Hsap IMLGDKDKVTVADFGLAKQKQ-ENSKLTSVVGTILYSCPEVLKSEPYGEKADVWAVGCIL NEK10_Mmus IMLGDKDKVTVTDFGLAKQKQ-ESSKLTSMVGTILYSCPEVLKSEPYGEKADVWAAGCIL pqn-25_Cele IMMTTDERVVITDFGLAKQKG--PEYLKSAAGTIIYSCPEIVQNLPYGEKADIWSFGCCI NEK10_Spur IMLGERDRVTITDFGLARARQPDASKMTSVVGTILYSCPEIVQSTPYGEKADVWAAGCVL AqueK177_Aque MILGEHDKLTITDFGLAKDQK-DFSVMKSIVGTVVYWCPEIVESKEYDKKADIWAAGCVL ::: :::.::*****: : . :.* .**::* ***:::. *.:***:*: ** : NEK10_Hsap YQMATLSPPFYSTNMLSLATKIVEAVYEPVPEGIYSEKVTDTISRCLTPDAEARPDIVEV NEK10_Mmus YQMATLSPPFCSTNMLSLATKIVEAVYEPVPEGIYSEKVTDTIRRCLTPDAEARPDIVEV pqn-25_Cele YEMCQLQPVFHSTNMLTLAMQIVEAKYDPLNE-MWSDDLRFLITSCLAPDPSARPDILKV NEK10_Spur YQMCTLKPPFYSANMLALASKVRKH----------------------------------- AqueK177_Aque YEMAALQPPFYATNLLSLAKKIAEGKFETAPLDKYSAQVSDVITKCLTIDPTLRPNSVQI *:*. *.* * ::*:*:** :: : NEK10_Hsap SSMISDVMMKYLDNLSTSQLS-LEKKLERERRRTQRYFMEANRNTVTCHHELAVLSHETF NEK10_Mmus SSMISDVMMKYLDRLSTSQLA-LERKLERERRRTQRYFMEANRNAVTCHHELALLSQETF pqn-25_Cele SGMCGVRLLEYLDDVARQQAS-TSDMTAS---QSSYNIKIDES----------------- NEK10_Spur ------------------------------------------------------------ AqueK177_Aque GGMIAEHLMVQLDSALAQIENKPNKESLSSSRRSSDAIEISERNALMSRRK--------- NEK10_Hsap EKASLSSSSS-GAA-SLKSELSESADLPPEGFQASYGKDEDRACDEILSDDNFNLENAEK NEK10_Mmus EKASLSSSSS-GAA-SLKSELSESAELPGEGCHIPCGKEEDRVCEEVLSEDNFQLESVEK pqn-25_Cele -PSSLNSSTSSYKRPGRSSKTSGSGKLPPI------------------------------ NEK10_Spur ------------------------------------------------------------ AqueK177_Aque --LSFSSTAS-DCE-PLDVTGGSVQDV--------------------------------- NEK10_Hsap DTYSEVDDELDISDNSSSSSSSPL--------KESTFN-----ILKRSFSASGGERQSQT NEK10_Mmus DLYSELDDELDVSDNCSSSSSSPL--------KESTFS-----ILKRSFSASGRERHSQA pqn-25_Cele ------------NP-------------------------------------------APR NEK10_Spur ------------------------------------------------------------ AqueK177_Aque ---SSYNNNPPVKGNAWKRETSPLLTAATTPNKQDTLSSEPIVSRQRSFSLSPAPTVRRS NEK10_Hsap RDFTGGTGSRPRPALLPLDLLLKVPPHMLRAHIKEIEAELVTG--WQSHSLPAVIL---- NEK10_Mmus RDFIAGLGSRPRPGRS---------------------GQVSAG--WQFQSLPAVTL---- pqn-25_Cele RNHSMSAGETPRPSSIVC------------------LPRITDKYSVMFPSAPSAIPSRRR NEK10_Spur ------------------------------------------------------------ AqueK177_Aque RST--------------------------------------------------------- NEK10_Hsap ------RNLKDHGPQMGTFLWQASAGIAVSQRKVRQISDPIQQILIQLHKIIYITQLPP- NEK10_Mmus ------HSPKHHGNAQQIILILTSAGIAVSQRKVRQICDPIQQILIQLHKVIYITQLPP- pqn-25_Cele VQTCSTEHPARSSSSTELKVSKQSDGLTVSSNVLRQIQDPVLTILNQIHRILVVTDKETI NEK10_Spur ------------------------------------------------------------ AqueK177_Aque --------------------RSGSTVITVSPLSLREISDPVSDVLLMMCKVLYINQLSPI NEK10_Hsap A-LHHNL--KRRVIERFKKSLFSQQ--SNPCNLKSEIKKLSQGSPEPIEPNFFTADYHLL NEK10_Mmus A-LHHDL--KRRVIERFKKSLFSQQ--SNPCNLKSEIKKLSQGSPEPIELNFLTSDYHSL pqn-25_Cele S-TSMNH--QRRLVEMFRKNLLGRE--NDAVQMKTHLRKLAAESPEEIQMNLGFSDFRPV NEK10_Spur ------------------------------------------------------------ AqueK177_Aque AKFEHSSSPPYIIVSRYTRGLLSSIASFNAKELKNELWRLATGINQEVS--LLPSLPHLL NEK10_Hsap HRSSGGNSLSPNDPTGLPTSIELEEGITYEQMQTVIEEVLEES----------------- NEK10_Mmus RHSRAANNWSPSDPTGSPSSFEVEEGVTYEQMQTVIEEVLEES----------------- pqn-25_Cele LVQSHINGYQKDQ---------KVTKITYEQLSACIECLIAENPAAKHVPHRTRAVVILR NEK10_Spur ------------------------------------------------------------ AqueK177_Aque EAAL---VQCPNAPS----PATNNHKTTYSQLQIFIEEVLKKT----------------- NEK10_Hsap ------------------------------------------------------------ NEK10_Mmus ------------------------------------------------------------ pqn-25_Cele RDLLVLGQYVNMLVPTITTYVVIRQIHVSLAAILVYTEYECGSNSSPQVSASGQVVTCST NEK10_Spur ------------------------------------------------------------ AqueK177_Aque ------------------------------------------------------------ NEK10_Hsap ------------------------------------------------------------ NEK10_Mmus ------------------------------------------------------------ pqn-25_Cele NTQCASGYTCNNGACCPNTNSNTCSSNGNNGCLAGQTMVNGQCYNSVNIGSACQSTQQCL NEK10_Spur ------------------------------------------------------------ AqueK177_Aque ------------------------------------------------------------ NEK10_Hsap --------------GYYNFT---------------------------------------- NEK10_Mmus --------------GYYNFT---------------------------------------- pqn-25_Cele GGSQCQNNICQCYSGYVNVNQQCVISNGLNCQLGTVSYNSQCITLASPGQNCQTSSQCID NEK10_Spur ------------------------------------------------------------ AqueK177_Aque --------------NYY------------------------------------------- NEK10_Hsap ------------------------------------------------------------ NEK10_Mmus ------------------------------------------------------------ pqn-25_Cele NSVCMNQMCTCNNNYRLVYGYCVPITSSICQQTQTLVNNQCVLLSIVGETCIANQQCVGG NEK10_Spur ------------------------------------------------------------ AqueK177_Aque ------------------------------------------------------------ NEK10_Hsap ------------------------------------------------------------ NEK10_Mmus ------------------------------------------------------------ pqn-25_Cele AMCNSGTCQCTNGATAMYGYCISSSSSSCNSNQVSINGMCYNTVQVGGSCSFSQQCLNNA NEK10_Spur ------------------------------------------------------------ AqueK177_Aque ------------------------------------------------------------ NEK10_Hsap ------------------------------------------------------------ NEK10_Mmus ------------------------------------------------------------ pqn-25_Cele VCTNNICVSTFCSVSCSTNQVCISNQCYNYVSIGSQCVGSQQCLSNSQCISSICQCPQGT NEK10_Spur ------------------------------------------------------------ AqueK177_Aque ------------------------------------------------------------ NEK10_Hsap ------------------------------------------------------------ NEK10_Mmus ------------------------------------------------------------ pqn-25_Cele QQSNGVCTGNNNNNNQCQPNQVLINNQCYNTVSIGFQCQFPQQCLGNSQCMNSMCQCPTG NEK10_Spur ------------------------------------------------------------ AqueK177_Aque ------------------------------------------------------------ NEK10_Hsap ------------------------------------------------------------ NEK10_Mmus ------------------------------------------------------------ pqn-25_Cele STNVNGYCQGGSNGQCNSNQVLINNQCYNTVSIGFQCQFAQQCLGNSQCLNSICQCPSGS NEK10_Spur ------------------------------------------------------------ AqueK177_Aque ------------------------------------------------------------ NEK10_Hsap -----------------------SNRYHSYPWGTK------------------------- NEK10_Mmus -----------------------TKRCHSFPWVTK------------------------- pqn-25_Cele SNVNGYCQGGSNGQCNSNQVYYNNQCYNTVPIGSQCQITQQCLGNSQCMNSFCQCPSGTT NEK10_Spur ------------------------------------------------------------ AqueK177_Aque ------------------------------------------------------------ NEK10_Hsap ----------------------------------------------------------NH NEK10_Mmus ----------------------------------------------------------SY pqn-25_Cele NVNNFCTTSSSSSNLCSAGQTVQLDSSNQPINCLVSTCPNNSFCQYSSSGQRYVCCRSTS NEK10_Spur ------------------------------------------------------------ AqueK177_Aque ------------------------------------------------------------ NEK10_Hsap PTKR NEK10_Mmus TAKR pqn-25_Cele GKKK NEK10_Spur -FPM AqueK177_Aque --SN