CLUSTAL W (1.83) multiple sequence alignment PAK3_Hsap MSDGL------------------------------------------------------- PAK2_Hsap MSDNG------------------------------------------------------- PAK1_Hsap MSNNGL------------------------------------------------------ PAK3_Mmus MSDSL------------------------------------------------------- PAK2_Mmus MSDNG------------------------------------------------------- PAK1_Mmus MSNNGV------------------------------------------------------ pak-1_Cele MKAFS------------------------------------------------------- STE20_Scer MSNDPSA--------------------------------------------------VSE SKM1_Scer MKGVKKEG-------------WISYKVDGLFSFLWQKRYLVLNDSYLAFYKS-----DK- CLA4_Scer MSLSAAAN-------------K----------------------------IS-----DN- Pak3_Dmel MSFTKWF--------------------------------------------------K-- Pak_Dmel MSSE-------------------------------------------------------- Y38F1A.10_Cele MFQNSPM--------------------------------------------------M-- PakA_Ddis MEEKPKST---------------------------------------------------- PakB_Ddis MEQSKRVS-MMR-------E-KFEAQ-------------------------SNEAESSP- PakC_Ddis MISLEDLS-PTLWKSP---DKEGELKKQGHVVKNWKKRKFIIQ--------NDMLFYFK- PakD_Ddis MSRLQPQQ-QQRGRSSSFKD-NFQ--------------------------IQKPLQS--L 19075_Tthe MPQEWTQYNL-------------------------------------------------- 25909_Tthe MGGKGSKNNN-----------------------------------------------EE- PAK1_Spur MYHHHHH--------------------------------------------------LQ- CC1G_15304_Ccin MSLTS------------------------------------------------------- CC1G_00840_Ccin MSSPHTA--------------------------------------------------YNQ CC1G_02087_Ccin MSYHQVS--------------------------------------------------AN- AqueK235_Aque MATM-------------------------------------------------------- GK081_Glam MFKKKNK----------------------------------------------------- * PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer LPDKDSLDNGISN----------------------------------------------- SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis TPSEQQQQQQQQQQQQQQQQQQQQQQQQQNNANNNNNNNNNKFNNQYIQQMKNVENDIKK 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin ------------------------------------------------------------ CC1G_00840_Ccin RPKEPRRQSKITV----------------------------------------------- CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------------------------------------------------------------ SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis WIGEKCSSSLSDDFLEKDLMESLCTGTILCVLINMIKQGTIQKIHLQPNYLQRVENIRNY 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin ------------------------------------------------------------ CC1G_00840_Ccin ------------------------------------------------------------ CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------------------------------------------------DNERAMGGNGDG SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis LRACWLFGLHSKYFFPSSYLLSMTIENNDNSNSSKTTTNNNNNNNNNNNNNNNNNNNNNN 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin ------------------------------------------------------------ CC1G_00840_Ccin ------------------------------------------------EYHR-------- CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer GDGLR----LPRTTGTL-----------------------NVNALQKGTNAAH--E-AGG SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis NNNNRAIITSPNKNGGVNTMIVNLEYKEKIMINLTELCKISLKIKNFGSFLQ-----LS- 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ----------------------------------------HGPPKMSA-----QWSDPQ- CC1G_15304_Ccin ------------------------------------------------------------ CC1G_00840_Ccin -PSR---------ESIQ-----------------------EYNALLADAN-LHAAE-AAK CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap -DNEEKPP--------------------APPLRM--------NSN-----N--------- PAK2_Hsap -ELEDKPP--------------------APPVRM--------SSTIFSTGG--------- PAK1_Hsap -DIQDKPP--------------------APPMRN--------TSTMIGAGS--------- PAK3_Mmus -DNEEKPP--------------------APPLRM--------NSN-----N--------- PAK2_Mmus -ELEDKPP--------------------APPVRM--------SSTIFSTGG--------- PAK1_Mmus -DIQDKPP--------------------APPMRN--------TSTMIGAGS--------- pak-1_Cele -SYDEKPP--------------------APPIRF--------SSSATRE----------- STE20_Scer Y-KSMDPA-KNAETTNDDDNNVVSLDDPIQFTRV--------SSSSVISGM--------- SKM1_Scer ---CNEEPVL------------------SVPLTS--------ITN--------------- CLA4_Scer -DFQNIGPAP------------------RPPSSN--------SQG--------------- Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ---EDKPP--------------------APPVRL--------TSNRGGNER--------- Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ----------------------------TPPPSV--------SSLRQKFEQFLDKTDKGF PakB_Ddis -PPNRKP--P------------------PPNKRV--------QTNGTSSLN--------- PakC_Ddis -DKEERPV-G------------------AVPLRM--------SRCYENK----------- PakD_Ddis -SSSSSTP--------------------PPPINN--------NNNNNNNNN--------- 19075_Tthe ------------------------------------------------------------ 25909_Tthe -EIQEGKP--------------------FNFQKH--------ISI--------------- PAK1_Spur -SYTDSPP--------------------APPVRV--------SSSNSRDAR--------- CC1G_15304_Ccin -SIASGLS--------------------SPPTEG--------KRPQSRGKE--------- CC1G_00840_Ccin YIPSRAPP--------------------PPPTNS--------QRAKTPTDQ--------- CC1G_02087_Ccin -SLQPTRPAP------------------QAPQRRNDAQPLYSSNNLLSSSG--------- AqueK235_Aque ----DDPP--------------------IPPIRN--------VSTRDKE----------- GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------------------------------------------S----------------- SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------S----------------- Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis NATRNNYRGPVSSSTGIINDKEKKSHSYFKVREEGSNKRPSSFSASNPITPSSPQSTHSS PakB_Ddis -------------------------------------SSGSSFVSPSPSPSPSPQQP--- PakC_Ddis ------------------------------------------------------------ PakD_Ddis ------------------------------------------NNNN-------------- 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------F----------------- CC1G_15304_Ccin ------------------------------------------------------------ CC1G_00840_Ccin ------------------------------------------Q----------------- CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------------------------------------SSMSPHSNIDETKSLEAVTPNINT SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------G----------------------- Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis PIYRGVGYHQYSSVNSGNSYSGSGNNINNIINNSNNS----------------------- PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis --------------------------------------NNNDLLISNNSSN--------- 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin ------------------------------------------------------------ CC1G_00840_Ccin ---------------------------------------------------------RTR CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ----------------------------R------------------------------- PAK2_Hsap ----------------------------K------------------------------- PAK1_Hsap ----------------------------K------------------------------- PAK3_Mmus ----------------------------R------------------------------- PAK2_Mmus ----------------------------K------------------------------- PAK1_Mmus ----------------------------K------------------------------- pak-1_Cele ------------------------------------------------------------ STE20_Scer SNITPDHSADNTFSTI---NASE-----S------------------------------- SKM1_Scer ----------------------------V------------------------------- CLA4_Scer ----------------------------R------------------------------- Pak3_Dmel ------------------------------------------------------------ Pak_Dmel -------------GGV---GVGGGGLGGG------------------------------- Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis -------------NSNNLYGNNSNNQSSGSLGNFLIDKLEYSAATVTASDLKRERQQLFR PakB_Ddis --------------------------------------------------VKR------- PakC_Ddis ------------------------------------------------------------ PakD_Ddis ------------------------------------------------------------ 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin ----------------------------K------------------------------- CC1G_00840_Ccin S-------------SL-------------------------------------------- CC1G_02087_Ccin ----------------------------Y------------------------------- AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------------------------------------------------------------ SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis NKEEFTMESSSYGGSTIGDDDLDSLNGSSSQQFNHRNSSWADRRERFIKKVMNGQFNEVQ PakB_Ddis -------------PL--------------------------------------------- PakC_Ddis ------------------------------------------------------------ PakD_Ddis --------------------------ISSPNSFS-------------------------- 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin ------------------------------------------------------------ CC1G_00840_Ccin ------------------------------------------------------------ CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer -----------------------------------------------------DHQFNDT SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis MRDELNRLRDIEADKIRAEERRTPSMNMDEFKAIEIERLRKKIYQEELVIFRQEEIEKIQ PakB_Ddis ------------------------------------------------PSPG-------- PakC_Ddis ------------------------------------------------------------ PakD_Ddis ------------------------------------------------------------ 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin ------------------------------------------------------------ CC1G_00840_Ccin ------------------------------------------------------------ CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer LLSKLSLTDSTETIENNATVKHQQPVASSTVNSNKSSTDIRRATPVSTPVISKPSMT--- SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis REERIKIEKEYDDKSIISSQERQHIVQQIINQKEDEKGSSPPFPI--------------- PakB_Ddis -----------------------------------VNKQAPPALPTQPRPQQQQPEIPVR PakC_Ddis ------------------------------------------------------------ PakD_Ddis --------------------------------------DS----PM-------------- 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin ------------------------------------------------------------ CC1G_00840_Ccin -LHKQNPRARNHS---LSSQPHHDPFA-ANVNSQE-SSFVPPPSPMATHIYNKPPNGTSP CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer -TTPR------------------------------------------------------- SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ---PLVVNNNNNENNENDNNNNNNNNNNNNNNNNNNNNNNNKNIDLTSFNNNININSNNN PakB_Ddis PTTPT------------------------------------------------------- PakC_Ddis ------------------------------------------------------------ PakD_Ddis ------------------------------------------------------------ 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin ------------------------------------------------------------ CC1G_00840_Ccin PPRPS------------------------------------------------------- CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------------------------------------------------------------ SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis EIKNNVIVDSDDEEELERLEQLRRQREIERLREEEEENEDRVERELASRRRQEEDRIKRE PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis ------------------------------------------------------------ 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin ------------------------------------------------------------ CC1G_00840_Ccin ------------------------------------------------------------ CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ---------------------------------------------------QINSASHS- SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis EEEEEEEQRNYLRRLKELERIKQIEEEEEEERERQSQLQSSQQQQKSSSTQRSSNTVTST PakB_Ddis ---------------------------------------------------RTPPNLINS PakC_Ddis ------------------------------------------------------------ PakD_Ddis ---------------------------------------------------GFSSSINSS 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin ------------------------------------------------------------ CC1G_00840_Ccin ---------------------------------------------------RANTANLTD CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap -------------------------------------DS--------------------- PAK2_Hsap -------------------------------------DP--------------------- PAK1_Hsap -------------------------------------DA--------------------- PAK3_Mmus -------------------------------------DS--------------------- PAK2_Mmus -------------------------------------DP--------------------- PAK1_Mmus -------------------------------------DT--------------------- pak-1_Cele ------------------------------------------------------------ STE20_Scer -------------------------------L--S--NP--------------------- SKM1_Scer -------------------------------------SR--------------------- CLA4_Scer -------------------------------------TC--------------------- Pak3_Dmel ------------------------------------------------------------ Pak_Dmel -------------------------------------GM--------------------- Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis -------SSSSTG----------------------------------------------- PakB_Ddis NGTSGGSGFSSSSGNSGYSSSNNNNSNSNSSINMNGNHS--------------------- PakC_Ddis ------------------------------------------------------------ PakD_Ddis SN----------------------------------NSNLNTPNNYNNTNNNNNNNNNNN 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin -------------------------------------AL--------------------- CC1G_00840_Ccin IFPTQSQLAARRLSTPSAAPQVHEDGRFYADPNEA--MP--------------------- CC1G_02087_Ccin -------------------------------------NP--------------------- AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------SALNH------------------------------------- PAK2_Hsap ------------------LSANH------------------------------------- PAK1_Hsap ------------------GTLNH------------------------------------- PAK3_Mmus ------------------SALNH------------------------------------- PAK2_Mmus ------------------LSANH------------------------------------- PAK1_Mmus ------------------GTLNH------------------------------------- pak-1_Cele -------------------NQVV------------------------------------- STE20_Scer ------------------KHKQH------------------------------------- SKM1_Scer ------------------IQLKQ------------------------------------- CLA4_Scer ------------------Y---N------------------------------------- Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------GDVPP------------------------------------- Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis -----------------------GDSNPSTSQKPTNLLNLMGSNNNISNINTNILSHSIV PakB_Ddis ------------------NGLNGGSSNPVPMRKVSSPIN--------------------- PakC_Ddis -------------------SLG-------------------------------------- PakD_Ddis NNNNNNINNLTPQMIISSPTSTS------------------------------------- 19075_Tthe ------------------------------------------------------------ 25909_Tthe -------------------QVDQ------------------------------------- PAK1_Spur ------------------DNMNP------------------------------------- CC1G_15304_Ccin ------------------SFLKF------------------------------------- CC1G_00840_Ccin ------------------HNQNM------------------------------------- CC1G_02087_Ccin ------------------SFAYS------------------------------------- AqueK235_Aque -------------------PAKN------------------------------------- GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------------------------------------------------------------ SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis NS-SGGLPPPPPTASHVDNRS-----RSHTLAGESHSSENTPLVSSIDNNGVNNKMSRSH PakB_Ddis -IANGTTPPPPPQPTPSQQPQQSPSSAS-----HNNTQH--------------------- PakC_Ddis ------------------------------------------------------------ PakD_Ddis ------------------------------------------------------------ 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin ------------------------------------------------------------ CC1G_00840_Ccin ------------------------------------------------------------ CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap -----------SSKPLPM------------------------------------------ PAK2_Hsap -----------SLKPLPS------------------------------------------ PAK1_Hsap -----------GSKPLPP------------------------------------------ PAK3_Mmus -----------SSKPLPM------------------------------------------ PAK2_Mmus -----------SLKPLPS------------------------------------------ PAK1_Mmus -----------GSKPLPP------------------------------------------ pak-1_Cele -----------GLKPLPK------------------------------------------ STE20_Scer -----------KPKVKPS------------------------------------------ SKM1_Scer -----------NCFEILR----------------------ATD---Q----KE------- CLA4_Scer -----------QTQPITK----LMSQLDLTSASHLGT---STS---K----KKSGWVSYK Pak3_Dmel ------------------------------------------------------------ Pak_Dmel -----------DMRPLPK------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis SGGALSGLALPTAPPLPNQPNVNNSNNNNNNNNINNNHNHSHNHSNNLHQSALKNSSSMS PakB_Ddis --------NIPSPPPLPNNKP---KKLAPTAVPAGLGSIIGGPKTPAISPGSTSP----- PakC_Ddis -------------K--PNCFE--------------------------------------- PakD_Ddis -----------STPPLPP------------------------------------------ 19075_Tthe ------------------------------------------------------------ 25909_Tthe -----------NG-KLIN------------------------------------------ PAK1_Spur -----------GSKPLPN------------------------------------------ CC1G_15304_Ccin -----------G-KRSPK------------------------------------------ CC1G_00840_Ccin -----------NDYPLPP------------------------------------------ CC1G_02087_Ccin -----------SSTPINQ----NYSQS----YSGIGGTPNRGADDTMNQQIVRNGSVSMK AqueK235_Aque -----------GSRPV-------------------------------------------- GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------------------------------------------------------------ SKM1_Scer ------------------------------------------------------------ CLA4_Scer DDGILSFIWQKRYLMLHDSYVALYKNDKQNDDAILKIPLTSIISVSRTQLKQYCFELVRC Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis TPSISPSQAGNSATSTVPSSPISASTSMSSPTL------VVSPRKDELTTSTGSTRKGSI PakB_Ddis -----------SLGSSNGNIPISTTSTPITPTPPISVPLATSPNNSH------------- PakC_Ddis ------------------------------------------------------------ PakD_Ddis ------------------------------------------------------------ 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin ------------------------------------------------------------ CC1G_00840_Ccin ------------------------------------------------------------ CC1G_02087_Ccin EDGFGNWLWQRKWLILREQALTIHKNENSPHQT--MILLRDISNIERTDLKPYCL----- AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------------------------------------------------------------ SKM1_Scer ----NIS-----P----------------------------------------------- CLA4_Scer SDRNSVSSGSSSS----------------------------------------------- Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis SEREDKKKVSSSSTSSSSSSNGGLSSSGKDHKKD-------------------------- PakB_Ddis -------------------------------KDSISNSNSNNNNNNNNNNNNNSSNATTS PakC_Ddis ------------------------------------------------------------ PakD_Ddis ------------------------------------------------------------ 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin ------------------------------------------------------------ CC1G_00840_Ccin ------------------------------------------------------------ CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap --------APEEKNK-KARL-RSIFPGG---GD--------------------------- PAK2_Hsap --------VPEEKKP-RHKI-ISIFSG----TE--------------------------- PAK1_Hsap --------NPEEKKK-KDRFYRSILPG-----D--------------------------- PAK3_Mmus --------APEEKNK-KARL-RSIFPGG---GD--------------------------- PAK2_Mmus --------VPEEKKP-RNKI-ISIFSG----TE--------------------------- PAK1_Mmus --------NPEEKKK-KDRFYRSILPG-----D--------------------------- pak-1_Cele --------EPEATKK-KKTM-PNPFMK----KN--------------------------- STE20_Scer --------KPEAKSK-PVSV-KKSFPSKNPLKNS-------------------------- SKM1_Scer -----INSYFYESNS-KRSIF----IS-----T--------------------------- CLA4_Scer -----LNV-SSDSNS-KKSIY----IA-----T--------------------------- Pak3_Dmel ------------------------------------------------------------ Pak_Dmel --------EPDDSDR-KKKTLKSKIKG-----S--------------------------- Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis -------HSSEEKEKEKKSFFNKLFSK-----E--------------------------- PakB_Ddis PPSPPVSNVGNKQDEEKKGFL-SIFTN--------------------------------- PakC_Ddis ---LV------SPRINKTFFIQANTPD-----E--------------------------- PakD_Ddis --------CANNINN-NNLKKRTKIPKNNNN-NNNNNNNNNNNNNNNNNNNNNNNNNNKI 19075_Tthe -------------------K-INYDRKK---TI--------------------------- 25909_Tthe --------VPEEWKK-YGLG-LDIDETK---TV--------------------------- PAK1_Spur --------TPPEEQKKGPKWMKNILKG-----G--------------------------- CC1G_15304_Ccin --------SPPTKDAS---W-DSAVPP--------------------------------- CC1G_00840_Ccin --------PPPPSAPLPARV-RS--------GT--------------------------- CC1G_02087_Ccin --------L-LETKD-KR-YF----LS-----L--------------------------- AqueK235_Aque -------------DKK-A----GFFKK-----D--------------------------- GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------------------------------------------------------------ SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis IIKRDCKKVYRKRKSSNCDNDDNGSNSDSDSSDSSDSSDSDSDSLLSSDGTPIILSQSSN 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin ------------------------------------------------------------ CC1G_00840_Ccin ------------------------------------------------------------ CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap --------------------------------------------K--------------- PAK2_Hsap --------------------------------------------K--------------- PAK1_Hsap --------------------------------------------K--------------- PAK3_Mmus --------------------------------------------K--------------- PAK2_Mmus --------------------------------------------K--------------- PAK1_Mmus --------------------------------------------K--------------- pak-1_Cele --------------------------------------------K--------------- STE20_Scer -------------------------------------------SP---------PKKQTE SKM1_Scer --------------------------------------------R---------TERD-- CLA4_Scer --------------------------------------------K---------TESD-- Pak3_Dmel ------------------------------------------------------------ Pak_Dmel --------------------------------------------K--------------- Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis --------------------------------------------K---------KD---- PakB_Ddis ------------------------------------------------------------ PakC_Ddis --------------------------------------------M--------------- PakD_Ddis PESVSFKSFIKEILHLKNIISKQDKTITSQKQTIETLEKDLEFQ------------KQLT 19075_Tthe --------------------------------------------VTKNFPKSVR-ASK-- 25909_Tthe --------------------------------------------KTKKMPEVVRFENE-- PAK1_Spur --------------------------------------------K--------------- CC1G_15304_Ccin ------------------------------------------------------------ CC1G_00840_Ccin --------------------------------------------K---------SKKG-- CC1G_02087_Ccin --------------------------------------------K---------NDEE-- AqueK235_Aque --------------------------------------------K--------------- GK081_Glam --------------------------------------------K--------------- PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer KSYY-------------SS----------------------------------------- SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis KKLLSSPIDLSNFIETSSDPNGAIPVSIQAFTRQIQQIQTLQQQNLSLETELSKTNEHLS 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin ------------------------------------------------------------ CC1G_00840_Ccin ------------------------------------------------------------ CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------SSKKRKSGSNSGTLRMKDVFTS-F------------------------------ SKM1_Scer -----------L--------------HG-W------------------------------ CLA4_Scer -----------L--------------HS-W------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis -------------HHSSSKSPSSGSSGGGE------------------------------ PakB_Ddis -----------------------------K------------------------------ PakC_Ddis --------------------------AS-W------------------------------ PakD_Ddis TNIRKNS------------KLENEV-LS-IETELLNLRMKYANTLSSSNSNGNNNSNNNS 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin ------------------------------------------------------------ CC1G_00840_Ccin -----------V--------------LG-F------------------------------ CC1G_02087_Ccin -----------L--------------YG-W------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------------------------------------------------------------ SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis LGCNNSINGSSSGGGGNNSSTSKGTLSRTISQPFPLRKSISHSNIITSPVNSHQQQQQQN 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin ------------------------------------------------------------ CC1G_00840_Ccin ------------------------------------------------------------ CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------------------------------------------------------------ SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis QLSQSQTTSPKNTSASYNNGILSKSSIVSNTNTNSTYKFGSSTGILKVSATLQQKQQQQQ 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin ------------------------------------------------------------ CC1G_00840_Ccin ------------------------------------------------------------ CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------------------------------------------------------------ SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis QQQNQQQQQNQQQQQQNQQQQNQQQQNQQKQNQQQQNQQQQQQQQQQQQQNQQQQQQQQQ 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin ------------------------------------------------------------ CC1G_00840_Ccin ------------------------------------------------------------ CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------------------------------------------------------------ SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis QQQQQQQQQNQQQQQNNQLSQSQQLQQQQNQQINNLIDSPLIISNSSNQQIESESIESDS 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin ------------------------------------------------------------ CC1G_00840_Ccin ------------------------------------------------------------ CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------------------------------------------------------------ SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis DYDKDMVDFGKKIVSALISSSNHVEMSEIYKMNDILTNETSRRQICIVLEEETKINQLKL 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin ------------------------------------------------------------ CC1G_00840_Ccin ------------------------------------------------------------ CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------------------------------------------------------------ SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis PMNENSFEVTLYLVNTILQCIHEAPSKDYFSLKLIMESSRILNRKKVNGSCEFIQEFIKD 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin ------------------------------------------------------------ CC1G_00840_Ccin ------------------------------------------------------------ CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------------------------------------------------------------ SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis HPTWKDIKFWEEQYWDELIIKHQQFSGSGSSSSSNTGGSIVTTMTTTTTVTSAITSSSST 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin ------------------------------------------------------------ CC1G_00840_Ccin ------------------------------------------------------------ CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer -------------------------------------------------------VQN-- SKM1_Scer -------------------------------------------------------L---- CLA4_Scer -------------------------------------------------------L---- Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis -------------------------------------------------------V---- PakB_Ddis -------------------------------------------------------K---- PakC_Ddis -------------------------------------------------------M---- PakD_Ddis TSDDFDVDYTELVNTLLISYVYNLASWGLSKSDVKEFTISMSKKSFLKSNELEKLIEQVT 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin ------------------------------------------------------------ CC1G_00840_Ccin -------------------------------------------------------M---- CC1G_02087_Ccin -------------------------------------------------------Q---- AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer --------------------------------------------------------IKRN SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis STVELSFTSDHNVCKGPHSFVLKSFRIISECNYCRQYIWGVRGIVAREAFECVGCKYKTH 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin ------------------------------------------------------------ CC1G_00840_Ccin ------------------------------------------------------------ CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap -------------T----NK-KKEKERPEISLPSDFEHTIHVGFDA--VT-GEFTNSPFQ PAK2_Hsap -------------G----SK-KKEKERPEISPPSDFEHTIHVGFDA--VT-GEFT----- PAK1_Hsap -------------T----NK-KKEKERPEISLPSDFEHTIHVGFDA--VT-GEFT----- PAK3_Mmus -------------T----NK-KKEKERPEISLPSDFEHTIHVGFDA--VT-GEFTNSPFQ PAK2_Mmus -------------G----SK-KKEKERPEISPPSDFEHTIHVGFDA--VT-GEFT----- PAK1_Mmus -------------T----NK-KKEKERPEISLPSDFEHTIHVGFDA--VT-GEFT----- pak-1_Cele ------------------DK-KEASEKPVISRPSNFEHTIHVGYDP--KT-GEFT----- STE20_Scer SQDDKRASSSSNNS----SS-SSITTALRISTPYNAKHIHHVGVDS--KT-GEYT----- SKM1_Scer -------------D----AIFAKCPLLSGVSSPTNFTHKVHVGFDP--KV-GNFV----- CLA4_Scer -------------D----AIFAKCPLLSGVSSPTNFTHKVHVGFDP--ET-GSFV----- Pak3_Dmel -------------K----KG-GDGGSISEIGAPTNFQRHFHVSRNQ--ET-GDLE----- Pak_Dmel -------------P-------SHTDSKPNISYPTNFEHTVHVGFDA--VT-GEFT----- Y38F1A.10_Cele -------------Y----DW-WNDTT---------------------------------- PakA_Ddis -------------D----EK-KKKKLSPRVGTPFNVKHDVHVNFNA--DT-G-FE----- PakB_Ddis -------------K----NK-DKK-KEFSVGSPFNVKHNIHVNYHS--VT-G-FE----- PakC_Ddis -------------K----AV-EKGSEYSTVSQPFNLKHEVHVDFNS--AT-G-FS----- PakD_Ddis KKCL-------KEA----SE-KTFCSSPNVGAPFNVKHEMHVGLA--------IQ----- 19075_Tthe -------------LPKEI-----------IDLITGVSLTPETNYSPLYSSQYTAE----- 25909_Tthe -------------LPENIQE-LISMLSLTVSKPENFARVHHIEIDP--SAPYGLK----- PAK1_Spur -------------S----DE-KGQRTRPEISLPTKFEHTVHVGFDN--IT-GEFT----- CC1G_15304_Ccin ---------------------LPSNGDDGISTPFNFQHNIHVNE--------GLV----- CC1G_00840_Ccin -------------S----EV-FNPTKRPEISTPYDPVHLTHVGFNS--ST-GEFT----- CC1G_02087_Ccin -------------D----DV-YSRSPLMGFSNPTNFVHKVHVGFDP--VS-GAFT----- AqueK235_Aque -------------K----S--AGDSKKLEISSPTGFEHTVHVGFDP--VS-GEFT----- GK081_Glam -------------N----AF-NEQIESSSISQPFDLKRGISVRYDP--QT-GKFT----- PAK3_Hsap TSRPVTVASSQSEGKMPDLYGSQMCPGKLPEGIPEQWARL--LQTSNITKLEQK------ PAK2_Hsap -------------------------------GMPEQWARL--LQTSNITKLEQK------ PAK1_Hsap -------------------------------GMPEQWARL--LQTSNITKSEQK------ PAK3_Mmus TSRPVTVASSQSEGKMPDLYGSQMCPGKLPEGIPEQWARL--LQTSNITKLEQK------ PAK2_Mmus -------------------------------GMPEQWARL--LQTSNITKLEQK------ PAK1_Mmus -------------------------------GMPEQWARL--LQTSNITKSEQK------ pak-1_Cele -------------------------------GMPEAWARL--LTDSQISKQEQQ------ STE20_Scer -------------------------------GLPEEWEKL--LTSSGISKREQQ------ SKM1_Scer -------------------------------GVPDSWAKL--LQTSEITYDDWN------ CLA4_Scer -------------------------------GMPTNWEKL--LKHSRITGEDWN------ Pak3_Dmel -------------------------------GLPAPWVRL--M-NSQITRDEQD------ Pak_Dmel -------------------------------GMPEAWARL--LMNSNISKQEQK------ Y38F1A.10_Cele ----------------------------------------------------KP------ PakA_Ddis -------------------------------GLPKEWEVL--IK-SNFQEPEVM------ PakB_Ddis -------------------------------GLPKEWEVI--LQSSGITREDVV------ PakC_Ddis -------------------------------GLPKEWEVI--LKSSNVSKQEVL------ PakD_Ddis -------------------------------GLPSGWRTL--LLQSGFQDYEIQ------ 19075_Tthe -------------------------------KITQEWDEI--VRENEQSKAIQQ------ 25909_Tthe -------------------------------GLPPEWEER--FKVQGINTEEVK------ PAK1_Spur -------------------------------GMPEKWAQL--LSSSSISKTEQK------ CC1G_15304_Ccin -------------------------------GLPPTWSAA--LSQAGFSDEEIIAIHNRR CC1G_00840_Ccin -------------------------------GLPKEWQQL--LQESGISRHEQE------ CC1G_02087_Ccin -------------------------------GLPEQWSKL--LTKSAITREDYA------ AqueK235_Aque -------------------------------GMPEAWAKL--LDSSGISQAEKA------ GK081_Glam -------------------------------GLPEEWQKLGLIPESMISTITDM------ PAK3_Hsap ------KNPQAVLDVLKF--------------------------------------YDSK PAK2_Hsap ------KNPQAVLDVLKF--------------------------------------YDSN PAK1_Hsap ------KNPQAVLDVLEF--------------------------------------YNSK PAK3_Mmus ------KNPQAVLDVLKF--------------------------------------YDSK PAK2_Mmus ------KNPQAVLDVLKF--------------------------------------YDSN PAK1_Mmus ------KNPQAVLDVLEF--------------------------------------YNSK pak-1_Cele ------QNPQAVLDALKY--------------------------------------YTQG STE20_Scer ------QNMQAVMDIVKF--------------------------------------YQDV SKM1_Scer ------RNSKAVIKALQF--------------------------------------YEDY CLA4_Scer ------NNSAAVIQVLQF--------------------------------------YQEY Pak3_Dmel ------KNPDAAYHAVKY--------------------------------------YNYS Pak_Dmel ------KNPQAVLDVLKW--------------------------------------FDNT Y38F1A.10_Cele ------KHQQPTLNVLSP--------------------------------------WGAY PakA_Ddis ------QHPEEVLDVVKF--------------------------------------HAQY PakB_Ddis ------EHSEVVIDVLDF--------------------------------------HMQQ PakC_Ddis ------DKPSEWLSVLEF--------------------------------------QAGR PakD_Ddis ------QHQEDVLDVLEF--------------------------------------HHVY 19075_Tthe ------PSFQDYKDLVEY--------------------------------------IIQN 25909_Tthe ------ENPQNMISIINN--------------------------------------YDQG PAK1_Spur ------NNPQAVLDALKF--------------------------------------YDDS CC1G_15304_Ccin AAGSRSPNSQYVLNARPPSPRIPHPYQQSASNVPIIAQPGPRTTSLPRQVSDASLRSTST CC1G_00840_Ccin ------KNPQAVMEIVKF--------------------------------------YQEG CC1G_02087_Ccin ------KDPQAVLDVLEF--------------------------------------YTDR AqueK235_Aque ------KNPDAVVKALEF--------------------------------------MTKR GK081_Glam ------ANAAPSLEDGGN--------------------------------------GDKP PAK3_Hsap ETV--NNQKY-------------------------------------------MSFT--- PAK2_Hsap TVK----QKY-------------------------------------------LSFT--- PAK1_Hsap KTS--NSQKY-------------------------------------------MSFT--- PAK3_Mmus ETV--NNQKY-------------------------------------------MSFT--- PAK2_Mmus TVK----QKY-------------------------------------------LSFT--- PAK1_Mmus KTS--NSQKY-------------------------------------------MSFT--- pak-1_Cele ESSG---QKW-------------------------------------------LQYD--- STE20_Scer TETNG-EDKMF------------------------------------------KTFN--- SKM1_Scer NGLDT--MQFN-------------------------------------------DHL--- CLA4_Scer NGAGN--PT-N-------------------------------------------TLD--- Pak3_Dmel IKKKE-NEVF-------------------------------------------KPFI--- Pak_Dmel TKQR-PSSKY-------------------------------------------MTNA--- Y38F1A.10_Cele FNHIG-NE-L-------------------------------------------LKEN--- PakA_Ddis QGLASA------------------------------------------------------ PakB_Ddis QQQQAQQEQ--------------------------------------------QALM--- PakC_Ddis TMEKSNSQN--------------------------------------------------- PakD_Ddis NEKQQNSIKL-------------------------------------------LTNN--- 19075_Tthe -DQ--------------------------------------------------------- 25909_Tthe IEA--------------------------------------------------------- PAK1_Spur TAGNE---KF-------------------------------------------MTQH--- CC1G_15304_Ccin --RQRHPIPFGSPASASTASLHSSNAGSISNIKAVRQGASQDHSSRNHTPQLSISYSSDS CC1G_00840_Ccin HGDVW-D-KLG-------------------------------------------NVG--- CC1G_02087_Ccin QKQEL--EDL--------------------------------------------SIG--- AqueK235_Aque SSHSDNDPKF-------------------------------------------LTAQ--- GK081_Glam L----I--KL-------------------------------------------SSQS--- PAK3_Hsap ------------------SG-------------------------DK------------- PAK2_Hsap ------------------PP-------------------------EK------------- PAK1_Hsap ------------------DK---------------------------------------- PAK3_Mmus ------------------SG-------------------------DK------------- PAK2_Mmus ------------------PP-------------------------EK------------- PAK1_Mmus ------------------DK---------------------------------------- pak-1_Cele ------------------MM-------------------------FIDDAPSRTPSYGLK STE20_Scer ------------------TT-------------------------TG------------- SKM1_Scer ------------------NT-------------------------SLDLK---------- CLA4_Scer ------------------KP-------------------------QSGET---------- Pak3_Dmel ------------------TEDVIHEESKEIENYVNYKNKHKSQDPEKS------------ Pak_Dmel ------------------IT-------------------------TH------------- Y38F1A.10_Cele -----------------------------------------S--NDK------------- PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------------------QK---------------------------------------- PakC_Ddis ------------------------------------------------------------ PakD_Ddis ------------------SN---------------------------------------- 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------KV---------------------------------------- CC1G_15304_Ccin NHSGVSGEDVYQQSRNGNFP-------------------------KDVSTPPGKPAHAAN CC1G_00840_Ccin ------------------AP-------------------------TP------------- CC1G_02087_Ccin ------------------AP-------------------------PRFNAGTGLGGLGKQ AqueK235_Aque ------------------RY---------------------------------------- GK081_Glam ------------------ID-------------------------K-------------- PAK3_Hsap -----------------------------------------------------SAH-G-- PAK2_Hsap -------------------------------------------------------D-G-- PAK1_Hsap -----------------------------------------------------SAE-D-- PAK3_Mmus -----------------------------------------------------SAH-G-- PAK2_Mmus -------------------------------------------------------D-G-- PAK1_Mmus -----------------------------------------------------SAE-D-- pak-1_Cele PQPYSTSSLPYHGNKIQDPR------KMNPMTTST------------------SSA-G-- STE20_Scer -----------------------------------------------------LPGSPQ- SKM1_Scer ---------------P-LKS------PTRYIINKR-TNSIK-R----------SVS---- CLA4_Scer -------------SSSQKSL------PNSYNDNKLRNNSVNSK----------SSS-G-- Pak3_Dmel -----------------------------------------------------DDD-G-- Pak_Dmel -----------------------------------------------------SGS-SLS Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis -----------------------------------------------------QM----- PakC_Ddis ------------------------------------------------------------ PakD_Ddis -----------------------------------------------------NNN-N-- 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur -----------------------------------------------------ILG-N-- CC1G_15304_Ccin PS------------IAQSFMSQASSLLNGHSHNRNESNASSTSKRLFGSQPSLWSS-P-- CC1G_00840_Ccin -------------------------------------------------------E-P-- CC1G_02087_Ccin PGPAEIRPLPKRNETSPPGL------TGTDSDN--L-SSAAAR----------AAE-H-- AqueK235_Aque ---------------------------------------------------------G-- GK081_Glam ------------------------------------------------------QI-D-- PAK3_Hsap -YI--------------AAH---------P------SS-TK------------------- PAK2_Hsap -FP--------------SGT---------P------AL-NA------------------- PAK1_Hsap -YN--------------SSN---------A------LN-VK------------------- PAK3_Mmus -YI--------------AAH---------Q------SN-TK------------------- PAK2_Mmus -FP--------------SGT---------P------AL-NT------------------- PAK1_Mmus -YN--------------SSN---------T------LN-VK------------------- pak-1_Cele -YN--------------SKQ--GVPPTTFS------VN-EN------------------- STE20_Scer -VS--------------TPP---------A------NS-FN------------------- SKM1_Scer ------------------RT---------L------RKGKT------------------- CLA4_Scer -VS--------------SSM---------V------SQ-RK------------------- Pak3_Dmel -SSTATETESSSGCGSSAGNSNS------S------SI-ND------------------- Pak_Dmel RVS--------------SSS---------P------SS-TPTDSELHGSNSGGNLIGVQL Y38F1A.10_Cele ----------SV--GDKNGN---------T------TT-NK------------------- PakA_Ddis ------------------------------------------------------------ PakB_Ddis -QQ--------------SGI---------P------AH-ML------------------- PakC_Ddis ------------------------------------------------------------ PakD_Ddis -NNNSNN------------------NLQQ------------------------------- 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur -KQ--------------SFE---------D------SF-EQ------------------- CC1G_15304_Ccin -SS--------------SST---------ASRPQTAANTST------------------- CC1G_00840_Ccin -YA--------------LAP---------E------NF-TN------------------- CC1G_02087_Ccin -VN--------------GSH---------V------AN-AI------------------- AqueK235_Aque -PT--------------PSR---------P------H--LS------------------- GK081_Glam -FH--------------TGN---------I------AP-SF------------------- PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------------------------------------------------------------ SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel GSMTLGPNANNVAVAGQILGNHYQQQQQHLLQQQQPLLHQNHNQHHMGISQSHSYNFVGH Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis ------------------------------------------------------------ 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin ------------------------------------------------------------ CC1G_00840_Ccin ------------------------------------------------------------ CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap T----------------------------------------------------------- PAK2_Hsap K----------------------------------------------------------- PAK1_Hsap A----------------------------------------------------------- PAK3_Mmus T----------------------------------------------------------- PAK2_Mmus K----------------------------------------------------------- PAK1_Mmus T----------------------------------------------------------- pak-1_Cele R----------------------------------------------------------- STE20_Scer -------------------------------KFPPSTSDSHNYGSRTGTPMSNHVMSPTL SKM1_Scer D----------------------------------------------------------- CLA4_Scer T----------------------------------------------------------- Pak3_Dmel SSQQSTVPLDALEEVFKELKTNLEHRETLKAA---------------------------- Pak_Dmel T----------------------------------------------------------- Y38F1A.10_Cele T----------------------------------------------------------- PakA_Ddis ------------------------------------------------------------ PakB_Ddis N----------------------------------------------------------- PakC_Ddis ------------------------------------------------------------ PakD_Ddis --------------------------QQQQN----------------------------- 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur Q----------------------------------------------------------- CC1G_15304_Ccin S----------------------------------------------------------- CC1G_00840_Ccin P------------------------------RSPPPPP--KKQPSQASSVHTQHTQSTPT CC1G_02087_Ccin S----------------------------------------------------------- AqueK235_Aque Q----------------------------------------------------------- GK081_Glam L----------------------------------------------------------- PAK3_Hsap ----AS---------------------------EPP--L--------------------- PAK2_Hsap ----GT---------------------------EAP--A--------------------- PAK1_Hsap ----VS---------------------------ETP--A--------------------- PAK3_Mmus ----AS---------------------------EPP--L--------------------- PAK2_Mmus ----GS---------------------------ETS--A--------------------- PAK1_Mmus ----VS---------------------------ETP--A--------------------- pak-1_Cele ----SS---------------------------MPPSYA--------------------- STE20_Scer NTDSSS-------------------ANGKFIPSRPA--P--------------------- SKM1_Scer ----S-ILP-----VYQ-------------SELKPF--P--------------------- CLA4_Scer ----S-QPPNTKSPVSL---GS--------GSLPPI--NTKLPTSQSNIPRHLQNVPNQQ Pak3_Dmel ----PQ---------------------------EPP--P--------------------- Pak_Dmel ----VS---------------------------SST--S--------------------- Y38F1A.10_Cele ----TV---------------------------EPP--P--------------------- PakA_Ddis ------------------------------------------------------------ PakB_Ddis ----NP---------------------------KPP--T--------------------- PakC_Ddis ------------------------------------------------------------ PakD_Ddis ------------------------------------------------------------ 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ----AS---------------------------ITP--K--------------------- CC1G_15304_Ccin ----SN---------------------------HSN--A--------------------- CC1G_00840_Ccin SVGP--------------------------TSYRPA--P--------------------- CC1G_02087_Ccin ----SVQGPRGPLPVPTLPQATRAAPPRPIAASRPP--P--------------------- AqueK235_Aque ----DT---------------------------FTP--L--------------------- GK081_Glam ----AT---------------------------NAT--L--------------------- PAK3_Hsap --------------------AP-------PVSEEED------------------------ PAK2_Hsap --------------------V---------VTEEE------------------------- PAK1_Hsap --------------------VP-------PVSEDED------------------------ PAK3_Mmus --------------------AP-------PVSEEED------------------------ PAK2_Mmus --------------------V---------VTEED------------------------- PAK1_Mmus --------------------VP-------PVSEDED------------------------ pak-1_Cele --------------------PP-------PVPHGE------------------------- STE20_Scer --------------------KP-------PSSASASAPIIKSPVMNSAANVSPLKQTHAP SKM1_Scer --------------------RP-------SDDDY-------------------------- CLA4_Scer YPKMRNGHSPTNGQFPRGPMHPNNSQRSLQQQQQ-------------------------- Pak3_Dmel --------------------VP-------PK---K------------------------- Pak_Dmel --------------------Q--------HSSANED------------------------ Y38F1A.10_Cele -----------------------------PE---E------------------------- PakA_Ddis ------------------------------------------------------------ PakB_Ddis --------------------IP-------IRDANKQ------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis ------------------------------------------------------------ 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur --------------------PP-------SRPGQED------------------------ CC1G_15304_Ccin -----------------------------AVTQPTD------------------------ CC1G_00840_Ccin --------------------TP-------PTAATPALDR--------------STSQRTP CC1G_02087_Ccin --------------------QP-------PKDVT-------------------------- AqueK235_Aque --------------------QP-------IRPAPQP------------------------ GK081_Glam --------------------DS-------LYHIDQM------------------------ PAK3_Hsap -------------EEE-EEEED--------------EN-EPPPVIAPRPEHT-------- PAK2_Hsap -------------------DDD--------------EE-TAPPVIAPRPDHT-------- PAK1_Hsap -------------D-----DDD--------------DA-TPPPVIAPRPEHT-------- PAK3_Mmus -------------EEE-EEEED--------------DN-EPPPVIAPRPEHT-------- PAK2_Mmus -------------------DDD--------------ED-AAPPVIAPRPDHT-------- PAK1_Mmus -------------------DDD--------------DA-TPPPVIAPRPEHT-------- pak-1_Cele -------------------TP---------------AD-IVPPAIPDRPART-------- STE20_Scer TTPNRTSPNRSSISRN-ATLKK--------------EE-QPLPPIPPTKSKT-------- SKM1_Scer -------------KFT-NIEDNK--------------VREEGRVHV-SK----------- CLA4_Scer -------------QQQ-QQKQQHQQYPYHHQGPSPSPSPSPSPLNPYRPHHN-------- Pak3_Dmel -------------------SPH--------------TI-PPKPQIKPKPRVT-------- Pak_Dmel -------------DMLGPQHPQ--------------QQ-PPPPPVASRPERT-------- Y38F1A.10_Cele ----------------------------------------P-P----------------- PakA_Ddis ----------------------------------------PAM----------------- PakB_Ddis -------------------PHN--------------QL-QPTPHQPPQHHHQ-------- PakC_Ddis ------------------------------------------------------------ PakD_Ddis ------------------------------------QQ-LKQKLNITNNQQ--------- 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur -------------D----VSED--------------ED-AEAPAIAPRPAHS-------- CC1G_15304_Ccin ------------------------------------NN-ASPEASPPQPKRT-------- CC1G_00840_Ccin AKPARPA----DIGRS-NTTRD--------------RR-SPAPP---ANNGLAAGSKSYS CC1G_02087_Ccin -------------PST-DDLRNR--------------VKPQG--PVPLPVRN-------- AqueK235_Aque ---------------------P--------------GS-ETAPAIPPRPAIT-------- GK081_Glam -------------------DIL--------------TD-AVKPTL-PSKKLL-------- PAK3_Hsap --KS-IYT-----R---------------------------------------------- PAK2_Hsap --KS-IYT-----R---------------------------------------------- PAK1_Hsap --KS-VYT-----R---------------------------------------------- PAK3_Mmus --KS-IYT-----R---------------------------------------------- PAK2_Mmus --KS-IYT-----R---------------------------------------------- PAK1_Mmus --KS-VYT-----R---------------------------------------------- pak-1_Cele --LS-IYT-----K---------------------------------------------- STE20_Scer --SP-IISTAH-TP---------------------------------------------- SKM1_Scer ------------------------------------------------------------ CLA4_Scer --MINPYS-----K---------------------------------------------- Pak3_Dmel --QK-FSR-----T---------------------------------------------- Pak_Dmel --KS-IYT-----R---------------------------------------------- Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis --QQ-------------------------------------------------------- PakC_Ddis ------------------------------------------------------------ PakD_Ddis ------------------------------------------------------------ 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur --QS-RYY-----S---------------------------------------------- CC1G_15304_Ccin --NA-LPP-----RLSLHQASGSGDLSAWAGMLLSGLSSDLDDKLTLGPSPLGPTPLTPQ CC1G_00840_Ccin KPSP-GSSQTDLPL---------------------------------------------- CC1G_02087_Ccin --D-SLPT---------------------------------------------------- AqueK235_Aque --KN-K------------------------------------------------------ GK081_Glam --RS-LQT-----Q---------------------------------------------- PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------------------------------------------------------------ SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis ------------------------------------------------------------ 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin SAPASAATQGPSSFTVSNRPTHTSHSRSLGGESSKARPEPLSELEEPIDNDAQYANLSPP CC1G_00840_Ccin ------------------------------------------------------------ CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------------------------------------------------------------ SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis ------------------------------------------------------------ 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin WTGDAGSSSPLWSEIEGILSQGRSPTASEDRHEPGPYSAALAETFSPTLPFSPEEDRMAQ CC1G_00840_Ccin ------------------------------------------------------------ CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap ----------------------------------SVVE---------------------- PAK2_Hsap ----------------------------------SVID---------------------- PAK1_Hsap ----------------------------------SVIE---------------------- PAK3_Mmus ----------------------------------SVVE---------------------- PAK2_Mmus ----------------------------------SVID---------------------- PAK1_Mmus ----------------------------------SVIE---------------------- pak-1_Cele ----------------------------------PKEE---------------------- STE20_Scer ----------------------------------QQVA---------------------- SKM1_Scer ----------------------------------------------ESTADSQTKQLGKK CLA4_Scer ----------------------------------QPQSP-------LSSQSTQNQAIPRY Pak3_Dmel ----------------------------------SDIR---------------------- Pak_Dmel ----------------------------------PIED---------------------- Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis ---------------------------------N-------------------------- 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ----------------------------------RIEQ---------------------- CC1G_15304_Ccin ERRLRNEASRERLEREEDLNRLSVNTARPNRDSSRSIP---------------------- CC1G_00840_Ccin ----------------------------------KQSA---------------------- CC1G_02087_Ccin -------------------------------------APGIHQSASQRSQQEQRERQQQQ AqueK235_Aque -------------------------------------D---------------------- GK081_Glam ----------------------------------NIFI---------------------- PAK3_Hsap -------------------------------------S---------------IA----- PAK2_Hsap -------------------------------------P---------------VP----- PAK1_Hsap -------------------------------------P---------------LP----- PAK3_Mmus -------------------------------------S---------------IA----- PAK2_Mmus -------------------------------------P---------------IP----- PAK1_Mmus -------------------------------------P---------------LP----- pak-1_Cele -------------------------------------E---------------EK----- STE20_Scer -------------------------------------Q---------------------- SKM1_Scer EQK----------------------VIQSHLRRHDNNS---------------TF--RPH CLA4_Scer AQN----------------------SSPTAAHFQPQRT---------------AP--KPP Pak3_Dmel -------------------------------------RDEDSDNQHKINTDTIII----- Pak_Dmel -------------------------------------L---------------QP----- Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis ---------------------------------------------NTIININ---IT--- 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur -------------------------------------T---------------PP----- CC1G_15304_Ccin -------------------------------------P---------------TPIVPPP CC1G_00840_Ccin -------------------------------------P---------------G------ CC1G_02087_Ccin EQRRLEQREREREQREREREREREREEREAYRAQQERP---------------PL--APS AqueK235_Aque -------------------------------------L---------------PP----- GK081_Glam -------------------------------------S---------------RP----- PAK3_Hsap ---------------------------S-----------PAVPNKE-------------- PAK2_Hsap ---------------------------A-----------PV------------------- PAK1_Hsap ----------------------------------------VTPTRDVA------------ PAK3_Mmus ---------------------------S-----------PAAPNKE-------------- PAK2_Mmus ---------------------------A-----------PV------------------- PAK1_Mmus ----------------------------------------VTPTRDVA------------ pak-1_Cele ---------------------------I-----------P-------------------- STE20_Scer ---------------------------S-----------PKAPAQET------------- SKM1_Scer RLAPS------------------------------------A------------------ CLA4_Scer ISAPRAPYPSNQNATSN----THV---Q-----------PVAPKNDQ------------- Pak3_Dmel ---------------------------K-----------PAVGAQD-------------- Pak_Dmel -----------------------AIIPM-----------PVAP----A------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ---------------------------P-----------PQQHHHQ-------------- PakC_Ddis ------------------------------------------------------------ PakD_Ddis ---------------------------S-----------PSISVNNN------------- 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ---------------------------E-----------PSPPSPA-------------- CC1G_15304_Ccin RQLPN----------------------R-----------PA-PIDA-G------------ CC1G_00840_Ccin ---------------------------P-----------PAHPPRDR------------- CC1G_02087_Ccin KSAPGTAQPATQPATGPAGALEGPPPVL-----------PLQPKKVQ------------- AqueK235_Aque ---------------------------T-----------PP-PKSA-------------- GK081_Glam ---------------------------TGFTHKNHVTVDPTNATRY-IGLPKEWEAKLEA PAK3_Hsap ----------------------------VT-------P--------PSA----------- PAK2_Hsap ------------------------------------------------G----------- PAK1_Hsap ----------------------------TS-------PI------SPTE----------- PAK3_Mmus ----------------------------DI-------P--------PSA----------- PAK2_Mmus ------------------------------------------------G----------- PAK1_Mmus ----------------------------TS-------PI------SPTE----------- pak-1_Cele -----------------------------------------------DL----------- STE20_Scer -------------------------------------------VTTPTS----------- SKM1_Scer ----------------------------------------------PAT----------- CLA4_Scer ----------------------------STPQTMRQAPK------RPDA----------- Pak3_Dmel ----------------------------------------------AGA----------- Pak_Dmel ----------------------------TT-------PA------TPLQNHRTPGGISAP Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ----------------------------QQ-------QQ------QHNN----------- PakC_Ddis ------------------------------------------------------------ PakD_Ddis ----------------------------TYNNNNNN---NNNNEINPS------------ 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ----------------------------PA-------PA------HPSN----------- CC1G_15304_Ccin ----------------------------HS-------PS------PPNS----------- CC1G_00840_Ccin ----------------------------AD-------PRAQNHAPSPAA----------- CC1G_02087_Ccin ----------------------------I--Q-AADKPA------KPAG----------- AqueK235_Aque ----------------------------LK-------P--------PAH----------- GK081_Glam VGLDIQKIGQNKDDLDALCAIMDNFYDDKI-------PI------KPDD----------- PAK3_Hsap ------EN---------------------------------------------A--NSST PAK2_Hsap -------D---------------------------------------------S--HVDG PAK1_Hsap ------NN--T------------------------------------------T--PPDA PAK3_Mmus ------EN---------------------------------------------A--NSTT PAK2_Mmus -------D---------------------------------------------S--NVDS PAK1_Mmus ------NN--T------------------------------------------T--PPDA pak-1_Cele --------------------------------------------------------SKGQ STE20_Scer ------K---P------------------------------------------A--QARS SKM1_Scer ------KN---------------------------------------------H--DSKT CLA4_Scer ------DV---------------------------------------------A--QPGG Pak3_Dmel -------D---------------------------------------------D--NPDE Pak_Dmel AASPMMHNNATTTLDKNKNNANLYTPEPTVAQVSAGGPSSQVAGNQIAVPQAAV--APAA Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------NN--N------------------------------------------N--NNNN PakC_Ddis ------------------------------------------------------------ PakD_Ddis ------------------------------------------------------------ 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur -------A---------------------------------------------T--NATT CC1G_15304_Ccin ------SF---------------------------------------------D--SEES CC1G_00840_Ccin ------SN--L------------------------------------------A--KVAG CC1G_02087_Ccin ------GV---------------------------------------------A---AAA AqueK235_Aque ---------------------------------------------------------AGA GK081_Glam ------QD--F------------------------------------------MIQAFDG PAK3_Hsap -----------------L-YRN-------------------------------------- PAK2_Hsap -----------------A-AKS-------------------------------------- PAK1_Hsap -----------------L-TRN-------------------------------------- PAK3_Mmus -----------------L-YRN-------------------------------------- PAK2_Mmus -----------------G-AKS-------------------------------------- PAK1_Mmus -----------------L-TRN-------------------------------------- pak-1_Cele -----------------F-GVQ-------------------------------------- STE20_Scer -----------------L-SKE-------------------------------------- SKM1_Scer -----------------K-WHK-------------------------------------- CLA4_Scer --------------------VA-------------------------------------- Pak3_Dmel -------------------TIL-------------------------------------- Pak_Dmel -----------------T-PNT-------------------------------------- Y38F1A.10_Cele ---------------------V-------------------------------------- PakA_Ddis ------------------------------------------------------------ PakB_Ddis NNNNNNQQSAQQQSAGIL-SQQ-------------------------------------- PakC_Ddis ------------------------------------------------------------ PakD_Ddis -------------------SPN-------------------------------------- 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur -----------------Q-AQQ-------------------------------------- CC1G_15304_Ccin -----------------S-ASSSQSQDRYPTPTTANSTSSPLRYYLEPSPSPSQASFSPV CC1G_00840_Ccin -----------------V-ATP-------------------------------------- CC1G_02087_Ccin -----------------A-ALE-------------------------------------- AqueK235_Aque -----------------Q-QGG-------------------------------------- GK081_Glam -----------------TDKYA-------------------------------------- PAK3_Hsap ------------------------------------------------------------ PAK2_Hsap ------------------------------------------------------------ PAK1_Hsap ------------------------------------------------------------ PAK3_Mmus ------------------------------------------------------------ PAK2_Mmus ------------------------------------------------------------ PAK1_Mmus ------------------------------------------------------------ pak-1_Cele ------------------------------------------------------------ STE20_Scer ------------------------------------------------------------ SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel ------------------------------------------------------------ Pak_Dmel ------------------------------------------------------------ Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis ------------------------------------------------------------ PakB_Ddis ------------------------------------------------------------ PakC_Ddis ------------------------------------------------------------ PakD_Ddis ------------------------------------------------------------ 19075_Tthe ------------------------------------------------------------ 25909_Tthe ------------------------------------------------------------ PAK1_Spur ------------------------------------------------------------ CC1G_15304_Ccin VARHKEYPNVPPAYDIDEDLDEDDEEGTNLIIPHQIITAPSPQANRPTIVIENVSPGGAL CC1G_00840_Ccin ------------------------------------------------------------ CC1G_02087_Ccin ------------------------------------------------------------ AqueK235_Aque ------------------------------------------------------------ GK081_Glam ------------------------------------------------------------ PAK3_Hsap -------T---------------DRQ-RKKSKMTDEEILEKLR--------SIVSV-GDP PAK2_Hsap -------L---------------DKQ-KKKTKMTDEEIMEKLR--------TIVSI-GDP PAK1_Hsap -------T---------------EKQ-KKKPKMSDEEILEKLR--------SIVSV-GDP PAK3_Mmus -------T---------------DRQ-RKKSKMTDEEILEKLR--------SIVSV-GDP PAK2_Mmus -------S---------------DKQ-KKKAKMTDEEIMEKLR--------TIVSI-GDP PAK1_Mmus -------T---------------EKQ-KKKPKMSDEEILEKLR--------SIVSV-GDP pak-1_Cele -------A---------------RGQ-KAKKKMTDAEVLTKLR--------TIVSI-GNP STE20_Scer -------L--------------NEKK-REERERRKKQLYAKLN--------EICSD-GDP SKM1_Scer ----------------------EDLL-ELKNNDDSNEIIMKMK--------TVAID-VNP CLA4_Scer ----------------------KPKK-PARPTMSTAEIMSKLK--------KVTVN-ADP Pak3_Dmel ----------------------RRSK-EKRAQKTDAEIYVELR--------AICNS-DDP Pak_Dmel -------R---------------AAN-AKKKKMSDEEILEKLR--------TIVSV-GDP Y38F1A.10_Cele ----------------------RVRA-SHREKLSDSEVLNQLR--------EIVNP-SNP PakA_Ddis --------------------------HAPSIPLT-DEPPVTLN--------DLISL-DDP PakB_Ddis -------QEQQLEEMMCGGAYDDEQYDLNNQPLP-DETNVSLY--------DLVSQ-EDP PakC_Ddis -----------------------------LSALP-DESNLTLS--------DLVTK-EDP PakD_Ddis ----------------------NNNN-YYDSLLEIEEPSFTLK--------DLVSL-ENP 19075_Tthe -------------------------P-N-KERLSEYEFNKRAENI-------QIEE-NDP 25909_Tthe -------------------------P-KKIILPTNDEFLKIVENI-------GLQE-DDP PAK1_Spur -------E--------------RREK-MKKKKMSDDEILEKLSKxMTLNGGSIVSV-GDP CC1G_15304_Ccin STALPTGT--------------PASP-FQRYRGWLSEVVQPLE--------EYIDEGVDP CC1G_00840_Ccin ----------------------RRRE-KKVDKAKDEDIIKRLQ--------QICTD-ADP CC1G_02087_Ccin ----------------------KPKE-KRISTMTEVQIMEKLR--------QVVSD-EDP AqueK235_Aque -------A---------------QKR-DKKPKMSDAEVLAHLR--------QIVSI-GDP GK081_Glam -------V--------------PKFH-SLPTADTYNDILEKLH--------DNFTEVNTI : PAK3_Hsap KKKYTR-FEKIGQGASGTVYTALDIA---------------------T-GQ--EVAIKQM PAK2_Hsap KKKYTR-YEKIGQGASGTVFTATDVA---------------------L-GQ--EVAIKQI PAK1_Hsap KKKYTR-FEKIGQGASGTVYTAMDVA---------------------T-GQ--EVAIKQM PAK3_Mmus KKKYTR-FEKIGQGASGTVYTALDIA---------------------T-GQ--EVAIKQM PAK2_Mmus KKKYTR-YEKIGQGASGTVFTATDVA---------------------L-GQ--EVAIKQI PAK1_Mmus KKKYTR-FEKIGQGASGTVYTAMDVA---------------------T-GQ--EVAIKQM pak-1_Cele DRKYRK-VDKIGSGASGSVYTAIEIS---------------------T-EA--EVAIKQM STE20_Scer STKYAN-LVKIGQGASGGVYTAYEIG---------------------T-NV--SVAIKQM SKM1_Scer RPYFQL-VEKAGQGASGAVYLSKRIKLPQENDP--RFLK--SHCHRVV-GE--RVAIKQI CLA4_Scer SQCFKV-IEKAGQGASGSVYLAERTHIPTESNM--IELINNDIDEPHV-GD--KVAIKQM Pak3_Dmel RERYKT-TQEVGKGASGIVFIAADLQ---------------------N-ES--QVAVKTI Pak_Dmel NRKYTK-MEKIGQGASGTVYTAIESS---------------------T-GM--EVAIKQM Y38F1A.10_Cele LGKYEM-KKQIGVGASGTVFVANVAG---------------------S-TD--VVAVKRM PakA_Ddis KKIYYN-INKIGEGGAGEVFEAINSR---------------------T-NQ--TIAIKKM PakB_Ddis TKLFGEGSTKIGEGAAGEVFVVTQLK---------------------T-NN--KVAIKKM PakC_Ddis TKIYKN-MTKIGEGAAGEVFVATSSK---------------------N-NK--RVAIKKI PakD_Ddis IDLYKV-REVVGGGSTGKVYVGENSI---------------------T-GE--KVAIKKM 19075_Tthe SNHYDF-LSQIGKGATCKVYRCKNKQ---------------------T-GQ--ECAMRVI 25909_Tthe SKFYNF-GDKLGKGAMCQVFKATKRK---------------------TKNE--EFAVRVM PAK1_Spur KRKYSK-FEKIGQGASGVVYTAIEVA---------------------T-GQ--EVAIKQM CC1G_15304_Ccin RDHYLD-LKEIAEGESGSVFSARLIQKDADKLRLPAHVKAQDADDFAN-NREVLVAIKSV CC1G_00840_Ccin TKLYRN-LVKIGQGASGGVYTAYQVG---------------------T-NM--SVAIKQM CC1G_02087_Ccin KLIYSK-IKKVGQGASGHVYVAKELA---------------------T-GK--KVAIKEM AqueK235_Aque TKRYTK-MEKIGQGASGVVYTASEIA---------------------T-GN--EVAIKQM GK081_Glam ADVYSN-PQEVGHGSSGHVYRATEIK---------------------T-GN--VVAIKSI : . * *: *:: : PAK3_Hsap NLQ----------------QQPKKELIINEILVMRENKN-PNIVNYLDSYLVG--DELWV PAK2_Hsap NLQ----------------KQPKKELIINEILVMKELKN-PNIVNFLDSYLVG--DELFV PAK1_Hsap NLQ----------------QQPKKELIINEILVMRENKN-PNIVNYLDSYLVG--DELWV PAK3_Mmus NLQ----------------QQPKKELIINEILVMRENKN-PNIVNYLDSYLVG--DELWV PAK2_Mmus NLQ----------------KQPKKELIINEILVMKELKN-PNIVNFLDSYLVG--DELFV PAK1_Mmus NLQ----------------QQPKKELIINEILVMRENKN-PNIVNYLDSYLVG--DELWV pak-1_Cele NLK----------------DQPKKELIINEILVMRENKH-ANIVNYLDSYLVC--DELWV STE20_Scer NLE----------------KQPKKELIINEILVMKGSKH-PNIVNFIDSYVLK--GDLWV SKM1_Scer RLS----------------EQPKKQLIMNELLVMNDSRQ-ENIVNFLEAYIID-DEELWV CLA4_Scer VLS----------------KQPRKELIVNEILVMKDSRH-KNIVNFLEAYLRT-DDDLWV Pak3_Dmel DMK----------------NQSSKDLILTEIRVLKDFNH-KNLVNFLDAYLLEPEDQLWV Pak_Dmel NLS----------------QQPKKELIINEILVMRENKH-PNVVNYLDSYLVS--EELWV Y38F1A.10_Cele AFK----------------TQPKKEMLLTEIKVMKQYRH-PNLVNYIESYLVD-ADDLWV PakA_Ddis KLK----------------AQNL-KTVINEIGMMKNSNH-ENIVQYIDSYIVA-D-ELWV PakB_Ddis PLN----------------QQNM-KLIVTEIGIMKSCRH-QNIIDYIDSYLVG-D-SLWV PakC_Ddis EIN----------------NDNA-KLLVTEIAIMKTSHH-DNIVNYIDSYIVN-DRELWV PakD_Ddis KVD----------------NNNIK-NIINEISTMKNSKH-KNVIKYVSSHLVI--NHIWL 19075_Tthe RML----------------NPDQIEKTKMEILLMNESKN-NNIVQYYKSYIYM--DVIFM 25909_Tthe KLG----------------DEGSMNKIKIEMAIMKICQH-KNIVRYYETFKFM--SCLFM PAK1_Spur NLQ----------------QQPKKELIINEILVMRENKH-QNIVNYLDSYLVS--DELWV CC1G_15304_Ccin AIV--------------PSGSPKLKDLQHELGLMKGLHH-ENVIGLDSLYVDFLEDTLWI CC1G_00840_Ccin DLD----------------KQPKKDLIINEILVMRSSRH-PNIVNYIDSFLYK--NDLWV CC1G_02087_Ccin DLS----------------HQPRKELIVNEILVMKESQH-PNIVNFLNSYLVK-NNELWV AqueK235_Aque NLQ----------------QQPKKELIINEIIVMKEIKQ-PNIVNFLDSYLVG-ESELWV GK081_Glam SAINFLTDDGKKVRDIKSAEAATLMALKNEVALMYLSKECEYIVKLHKVYFSKAAKEFYM *: : .. :: . . ::: PAK3_Hsap VMEYLAGGSLTDVVTE---------------------TCMDEGQIAAVCRECLQALDFLH PAK2_Hsap VMEYLAGGSLTDVVTE---------------------TCMDEAQIAAVCRECLQALEFLH PAK1_Hsap VMEYLAGGSLTDVVTE---------------------TCMDEGQIAAVCRECLQALEFLH PAK3_Mmus VMEYLAGGSLTDVVTE---------------------TCMDEGQIAAVCRECLQALDFLH PAK2_Mmus VMEYLAGGSLTDVVTE---------------------TCMDEAQIAAVCRECLQALEFLH PAK1_Mmus VMEYLAGGSLTDVVTE---------------------TCMDEGQIAAVCRECLQALEFLH pak-1_Cele VMEYLAGGSLTDVVTE---------------------CQMEDGIIAAVCREVLQALEFLH STE20_Scer IMEYMEGGSLTDVVTH---------------------CILTEGQIGAVCRETLSGLEFLH SKM1_Scer IMEYMEGGCLTDILDAVARSNT-----------GEHSSPLNENQMAYIVKETCQGLKFLH CLA4_Scer VMEFMEGGSLTDIIENSPTND-------------NSHSPLTEPQIAYIVRETCQGLKFLH Pak3_Dmel VMEYMDGGPLTDVVTE---------------------TVMKERQIACVCRETLYAISFLH Pak_Dmel VMEYLPGGSLTDVVTE---------------------TCMDEGQIAAVCREVLQALEFLH Y38F1A.10_Cele VMDYLEGGNLTDVVVK---------------------TELDEGQIAAVLQECLKALHFLH PakA_Ddis AMEFMSGGCLTEVLDQY------------------RDIQLNESQIAFVCQEVLRGLEYIH PakB_Ddis AMEFMGGGCLTEILEQF------------------NSVKLVEAQIAYVCAETLKGLAYIH PakC_Ddis AMEFMGGGCLTDILEAF------------------DNIKMSEIQIAYVVKETLKALQYIH PakD_Ddis IMEYMSYGSLTDLISNCINIQCNGNNQQQQQQQQQQQTYFIESHIAYICQQVLQGMDYIH 19075_Tthe AIEYMNAGSLTELIYGN-------------------FSFLSEQMASYICEQILFGLFFIH 25909_Tthe VIEYMNGGSLTEIIYQN-------------------FKTIPEDIIAYILREIIQGLNFIH PAK1_Spur VMEFLAGGSLTDVVTE---------------------TCMDEGQIASVCRECLQALQFLH CC1G_15304_Ccin RMELME-RSLADIIGLVD-----------------AGLMLPDRMMARFASDILSGLDYLQ CC1G_00840_Ccin VMEYMEGGSLTDVVTA---------------------NLMTEGQIAAVSRETCQGLEHLH CC1G_02087_Ccin VMEYMEGGALTDVIEN---------------------NTLEEDQISSICLETCKGLQHLH AqueK235_Aque VMEYLAGGSLTDVVTE---------------------TCMNEGQIAAVCRECLQALKFLH GK081_Glam IMDYCNANCLTNILSRH-------------------GYIKNERVSCMIIRDILKALNHLH :: *:::: : . : .: .:: PAK3_Hsap SNQVIHRDIKSDNILLGMD----------------GSVKLTDFGFCAQITPEQSKRSTMV PAK2_Hsap ANQVIHRDIKSDNVLLGME----------------GSVKLTDFGFCAQITPEQSKRSTMV PAK1_Hsap SNQVIHRDIKSDNILLGMD----------------GSVKLTDFGFCAQITPEQSKRSTMV PAK3_Mmus SNQVIHRDIKSDNILLGMD----------------GSVKLTDFGFCAQITPEQSKRSTMV PAK2_Mmus ANQVIHRDIKSDNVLLGME----------------GSVKLTDFGFCAQITPEQSKRSTMV PAK1_Mmus SNQVIHRDIKSDNILLGMD----------------GSVKLTDFGFCAQITPEQSKRSTMV pak-1_Cele SRHVIHRDIKSDNILLGMD----------------GSVKLTDFGFCAQLSPEQRKRTTMV STE20_Scer SKGVLHRDIKSDNILLSME----------------GDIKLTDFGFCAQINELNLKRTTMV SKM1_Scer NKKIIHRDIKSDNILLNSQ----------------GLVKITDFGFCVELTEKRSKRATMV CLA4_Scer DKHIIHRDIKSDNVLLDTR----------------ARVKITDFGFCARLTDKRSKRATMV Pak3_Dmel AKGIIHRDIKSDNVLLGMD----------------GSVKVTDFGFCANIEG-DEKRQTMV Pak_Dmel ANQVIHRDIKSDNILLGLD----------------GSVKLTDFGFCAQISPEQSKRTTMV Y38F1A.10_Cele RHSIVHRDIKSDNVLLGMN----------------GEVKLTDMGFCAQIQP-GSKRDTVV PakA_Ddis KFNRIHRDIKSDNILIGAN----------------GEIKLADFGYAAQLTQIRQERNSVV PakB_Ddis SQHRIHRDIKSDNILLGSD----------------GSVKLADFGYAAQLTKSKQKRVTIV PakC_Ddis SLHRIHRDIKSDNILLGSE----------------GSVKIADFGYAAQLTQKQQKRNTVV PakD_Ddis KGHRTHRDIKSDNILLGKD----------------GSVKIADFGFVANLTRKKLQRNSVV 19075_Tthe RTNQIHRDLKSDNILLNQN----------------GDVKIADFGFATQLTREHFSKKSQV 25909_Tthe LQNQAHRDLKSDNILVNKN----------------GEVKVADFGFATQLTQEKQRRKSVV PAK1_Spur QRHVIHRDIKSDNILLGMD----------------GNVKLTDFGFCAQITPEQSKRTTMV CC1G_15304_Ccin RHHIAHRDVRSDNLLINKH----------------GVLKLTDFANAVQVSAQNPMRTEPA CC1G_00840_Ccin RHGVIHRDIKSDNVLLSMV----------------GDIKLTDFGFCAQISEGHAKRTTMV CC1G_02087_Ccin SQSIIHRDIKSDNVLLDAQ----------------GRVKITDFGFCAKLTDQKSKRATMV AqueK235_Aque DNHVIHRDIKSDNILLGMD----------------GQVKLTDFGFCAQITPEQSKRSTMV GK081_Glam ENHRIYRDLKSDNVLLNAELINSLAQDGAITKKKKFSLKLSDFGFAVQLNTKQPTRKSVV :**::***:*:. :*::*:. ..: : . PAK3_Hsap GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQ PAK2_Hsap GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQ PAK1_Hsap GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQ PAK3_Mmus GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQ PAK2_Mmus GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQ PAK1_Mmus GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQ pak-1_Cele GTPYWMAPEVVTRKQYGPKVDVWSLGIMAIEMVEGEPPYLNENPLRAIYLIATNGKPDFP STE20_Scer GTPYWMAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLK SKM1_Scer GTPYWMAPEIVNQKGYDEKVDVWSLGIMLIEMIEGEPPYLNEDPLKALYLIANNGSPKLR CLA4_Scer GTPYWMAPEVVKQREYDEKIDVWSLGIMTIEMLEGEPPYLNEDPLKALYLIATNGTPKLK Pak3_Dmel GTPYWMAPEVVTRKKYGKKVDIWSIGIMAIEMIEGQPPYLYETPLRALYLIAANGRPDIK Pak_Dmel GTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIK Y38F1A.10_Cele GTPYWMSPEILNKKQYNYKVDIWSLGIMALEMIDGEPPYLRETPLKAIYLIAQNGKPEIK PakA_Ddis GTPYWMAPELIRGNNYDFKVDVWSLGIMTREMAEGEPPYLEFPPLRALFLLTTQGLPPIR PakB_Ddis GTPYWMAPELIRGQNYDRKVDIWSLGIMAMEMAESEPPYMSFPPLRALFLITTKGIPDLK PakC_Ddis GTPYWMAPELIRGHDYGVKVDIWSLGIMMMEMAEGEPPYMDFPPLRALFLITTKGIPPLK PakD_Ddis GTPYFMAPELIRGNQYNHKVDIWSLGILARELSEGEPPYAKYPPVRALFLLTLEGVPDFK 19075_Tthe GTPAWMAPELILRKDYSQKVDIWSLGVICIEILEGEPPYIRDKPAKAMYYITKK-KPHKL 25909_Tthe GTPAWMAPELILKKEYNEKVDVWSTGIIAIELAMGEPPHLRMPPLKAMYTISSKAPPRL- PAK1_Spur GTPYWMAPEVVTRKQYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPDIH CC1G_15304_Ccin GVLYWQAPEVRSPPYNAMKVDVWSLGATVWEMAETQPPFADTNEFG-------DRWPPLS CC1G_00840_Ccin GTPYWMAPEVVTRKEYGPKVDIWSLGIMAIEMIEGEPPYLNQNPLKALYLIATNGTPTIA CC1G_02087_Ccin GTPYWMAPEVVKQKEYGAKVDIWSLGIMAIEMIENEPPYLDEEPLKALYLIATNGTPTLK AqueK235_Aque GTPYWMAPEVVTRKQYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQ GK081_Glam GTPFWMAPELIRGTEYNTKVDCWSLGIVVLELCESLPPHMEMQPLKAVFKIVTSPAPSFK *. : :**: *:* ** * *: **. . * PAK3_Hsap NPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKL-AKPL--SSLTPLIIAA----K PAK2_Hsap NPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLKL-AKPL--SSLTPLIMAA----K PAK1_Hsap NPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQVRKLRF-QV-F--SNFSMIAASI----P PAK3_Mmus NPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKL-AKPL--SSLTPLIIAA----K PAK2_Mmus NPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLKL-AKPL--SSLTPLILAA----K PAK1_Mmus NPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKI-AKPL--SSLTPLIAAA----K pak-1_Cele GRDSMTLLFKDFVDSALEVQVENRWSASQLLTHPFLRC-AKPL--ASLYYLIVAA----K STE20_Scer EPENLSSSLKKFLDWCLCVEPEDRASATELLHDEYITEIAEAN--SSLAPLVKLA----R SKM1_Scer HPESVSKQTKQFLDACLQVNVESRASVRKLLTFEFLSM-ACSP--EQLKVSL-------- CLA4_Scer HPESLSLEIKRFLSVCLCVDVRYRASTEELLHHGFFNM-ACDP--KDLTSLLE------- Pak3_Dmel SWDKLSPNLQDFLDRCLQVEVDRRATADELLSHPFLND-CSEV--KALVPNIKAA----K Pak_Dmel EKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFLKL-ARPL--ASLTPLIMAA----K Y38F1A.10_Cele QRDRLSSEFNNFLDKCLVVDPDQRADTTELLAHPFLKK-AKPL--SSLIPYIRAV----R PakA_Ddis DAHKWSKEFNDFLALCLEKDTEKRASSSSLLHHPFLKR-ACSG--PEFYKAVDAA----R PakB_Ddis DQNKWSDDFKDFVKKCLDKDVENRPEAKVLLNHPFLKT-ACNS--NGLVPAIMEA----K PakC_Ddis ETTKWSKTFQDFFSKCLDINVANRPDATDLLKHPFMDL-ACDS--SEFKPLIQAA----R PakD_Ddis EPNKWSSDFIEFVNLCLNLDDKRRPDAHYLLRHPFLKK-ACSS--REFADKVEEI----Y 19075_Tthe DATKFSQEACDFVSTCLNIDPQERPTAQQLISHPFIQK-HCKS--RDQSKILLADLLLQK 25909_Tthe DPANFTQNFCNFVEQCLQKNPDERASFQTLLEHPFLKN-VPADAASKFASMVQN-----K PAK1_Spur NPDRLSPVFRNFLAKCLETDVDKRADGEMLLKHPFLST-AKPL--NSLKPLIAAA----R CC1G_15304_Ccin RPQLVSPAFHEFLRLCSEP-AASRPTAGELLKTPFVKN-ACGR--AVIVQLLSQC----I CC1G_00840_Ccin NPENLSPVFTDYLAKTLEVDAEKRPSATELLQHPFFKL-SEPL--RTLAPLIKAA----R CC1G_02087_Ccin KPEALSKELKSFLAVCLCVDVASRATAIELLDHEFLKK-ACQL--SGLAPLLRFK----T AqueK235_Aque NPENLSRVFRDFLDRCLEMEVDKRGSASELLTHVFLKK-AAPL--SSLTPLIIAA----K GK081_Glam KPSQWTPELNDFLARCLDKDPDSRWSCAQLLEHPWIKS-VDNA--P----L--------- : :. * *: . PAK3_Hsap E--------------------------------------------AIK-----------N PAK2_Hsap E--------------------------------------------AMK------------ PAK1_Hsap EDCQAP-----------------------------------LQPHSTD------------ PAK3_Mmus E--------------------------------------------AIK-----------N PAK2_Mmus E--------------------------------------------AMK------------ PAK1_Mmus E--------------------------------------------ATK------------ pak-1_Cele K--------------------------------------------SIA----------EA STE20_Scer LK-KVAENMDADEDNDDDNDNEHINKTNNCDDNNDSKETVNLDVTE------------DD SKM1_Scer ------------------------------------------------------------ CLA4_Scer ------------------------------------------------------------ Pak3_Dmel K--------------------------------------------VLR------------ Pak_Dmel E--------------------------------------------AT------------- Y38F1A.10_Cele ------------------------------------------------------------ PakA_Ddis I--------------------------------------------EKEN--QLQNF-ANL PakB_Ddis K--------------------------------------------AKEA--H-----SKF PakC_Ddis ------------------------------------------------------------ PakD_Ddis N--------------------------------------------TRKN--QFS---DIN 19075_Tthe K--N-----------------------------------------IKQSLIDFDQEANPI 25909_Tthe K--N-----------------------------------------IPLN--QL--FNIPK PAK1_Spur E--------------------------------------------A-------------- CC1G_15304_Ccin A--------------------------------------------IE------------S CC1G_00840_Ccin E---------------------------------------------------------IA CC1G_02087_Ccin -----------------------------------------------K------------ AqueK235_Aque E--------------------------------------------M-A------------ GK081_Glam ---------------------------------------------D------------LS PAK3_Hsap SSR PAK2_Hsap SNR PAK1_Hsap CCS PAK3_Mmus SSR PAK2_Mmus SNR PAK1_Mmus NNH pak-1_Cele SNS STE20_Scer KQK SKM1_Scer KWH CLA4_Scer WKE Pak3_Dmel RNV Pak_Dmel KGN Y38F1A.10_Cele -EK PakA_Ddis TAI PakB_Ddis SIH PakC_Ddis -NV PakD_Ddis FNF 19075_Tthe DSN 25909_Tthe DKQ PAK1_Spur PKH CC1G_15304_Ccin AFE CC1G_00840_Ccin KNK CC1G_02087_Ccin QAS AqueK235_Aque GKR GK081_Glam DYF