CLUSTAL W (1.83) multiple sequence alignment PakE_Ddis MEEDKDSDTLQILNDIINNEPNLEIYVKSKNNNYISSRELPTQDSSTKTSNITTPNNNNN PakF_Ddis MSNLKLSNNNN-------------------GNQKESSSFFQKVMKSPSTQNLLNSFSSNN PakG_Ddis MEEKIKSNLIH-------------------SKTNEDIELIKQKLKED--RELLE------ PakH_Ddis MVRLFRSGS--------------------------------------------------- PakH_C2d_Ddis MVRLFRSGS--------------------------------------------------- * . *. PakE_Ddis NNNNNNNNNNNNN-------------------------------------NNNNNNNNNN PakF_Ddis SNNNLSNSGSNEVKDTTTNSPSQLPPNYTPPPPPHQIRNSSSIEGGEFSLLNNENSDNNN PakG_Ddis ------------------------------------------------------------ PakH_Ddis ------------------------------------------------------------ PakH_C2d_Ddis ------------------------------------------------------------ PakE_Ddis NNNNNNNNNNNNNNNNNNNNNNNNTPTSLNSSWKSVVPKRKIDTSSGAILNNNNNVGSPN PakF_Ddis NNNNNNNNNNNNNNNNNNNNNNNNEQLARTESSVSII----------------------- PakG_Ddis ------------------------KERAQFEEERKII----------------------- PakH_Ddis ------------------------------------------------------------ PakH_C2d_Ddis ------------------------------------------------------------ PakE_Ddis NQSTSQTNHQQPPPQQLQQQQSLSSTSTPSISPPMLSPSRRNVTSPNLTRSDPTVPITNS PakF_Ddis ----------------------------------SSSSSGSNSGQPNLQRHSSNISTDDS PakG_Ddis ---------------------------------FESLNKVVGSGSANITKNIA------- PakH_Ddis ------------------------------------------------------------ PakH_C2d_Ddis ------------------------------------------------------------ PakE_Ddis RPTSPLTPPLSPQFQLNNLNFDD----NNDHSTTTTNNNNNNNNNNSNNNNNNNRPKLMR PakF_Ddis N-TTTETYSMSPNQTLNS-NIDSSEQQHQDLSSSVNNNNNNNNNNNNNNNNNNNNNNNNN PakG_Ddis ------------------KALKKAEK-KNGVGSNLNLANSSSGSNISVYNNNNNN----- PakH_Ddis ------------------------------------------------------------ PakH_C2d_Ddis ------------------------------------------------------------ PakE_Ddis ENSINKRSSLQTLPVSSSSSSSAEDEILIKVWLPMEYTGQLYKVRKFSGGSSTLKVSSML PakF_Ddis NNNNTHESRKLTRKIAQFISSPKLLQSSI-SQLPSTPTQQNVEIQTTNGGSSETSPNGLI PakG_Ddis -------------------------------------------------NNNN------- PakH_Ddis ---------------------------------------------------NP------- PakH_C2d_Ddis ---------------------------------------------------NP------- . PakE_Ddis NSQLS---PMYQSPKNKLFLNNEEKPIPSHLTLKDLSLSKYDILYLRREPEYELIIPSSP PakF_Ddis SPRPSNDQPLKEK-KKKKFLKTPEI-FKHHHHHKE------------------------- PakG_Ddis ------------------------------------------------------------ PakH_Ddis ------------------------------------------------------------ PakH_C2d_Ddis ------------------------------------------------------------ PakE_Ddis QCGSLVMDKDIKIDDMLIKIEHWLKDILDHAPHSTSQQQQQQLQQQPILHVDKHEYFTSL PakF_Ddis ------------------------------------------------------------ PakG_Ddis ------------------------------------------------------------ PakH_Ddis ------------------------------------------------------------ PakH_C2d_Ddis ------------------------------------------------------------ PakE_Ddis EDQQLMSGHITNSSQYTLLKKLSVPTSNSRQTGKMSRGYYLRLYDQKPISNYGIKIKDTL PakF_Ddis ------------------------------------------------------------ PakG_Ddis ------------------------------------------------------------ PakH_Ddis ------------------------------------------------------------ PakH_C2d_Ddis ------------------------------------------------------------ PakE_Ddis IFKKKILNRGLSIDDAEGGIEITVLYSPLSMLPTTSDLDFEKELKENQQQLNNNNNNNNN PakF_Ddis ------------------------------------------------------------ PakG_Ddis ------------------------------------------------------------ PakH_Ddis ------------------------------------------------------------ PakH_C2d_Ddis ------------------------------------------------------------ PakE_Ddis NNNNNNNNNNNNNNNITTTTTTTTSSLINQTNEILLPNLIKIDNTSLL--QDIKNEKKKR PakF_Ddis -----------SSLSSSTTTPSTTSSLTSSPSSSSLA--ISSPNTTAATTTNKKSHKKTK PakG_Ddis ------------------------------------------------------------ PakH_Ddis ------------------------------------------------------------ PakH_C2d_Ddis ------------------------------------------------------------ PakE_Ddis KSKRTPSSVGLPFNIIHKTHVDFEYKWSGTS-VEDTFEFKEKLGQGGYGAVFKVLHRETN PakF_Ddis STFDINTEISVPYNVIHKMHVDFDLKWTG----HNDFILDEKLGDGAYGSVYKGTHKDLG PakG_Ddis ----NSNNIGTPFNVQHKVHVDFDYKWSGCQDLEQVFLIDCILGTGSYGTVYKAIHKDTN PakH_Ddis ----KEIDISQPNSLVHKVHVDLDLNWSSG--GETSFEIQEKLGEGSFGSVYRAIHKSSN PakH_C2d_Ddis ----KEIDISQPNSLVHKVHVDLDLNWSSG--GETSFEIQEKLGEGSFGSVYRAIHKSSN .:. * .: ** ***:: :*:. . * :. ** *.:*:*:: *:. . PakE_Ddis FPLAIKVLSITPTRI-KDIEKEIDLLKKCRCPNVLSYYGSISSKLTELWILMDHCAVGSI PakF_Ddis FTLAIKVIEMKESES-VSLQNEINILKNCKSPNIVSYFGSLQTE-SHIWILLDFCALGSI PakG_Ddis FVLAIKSIPIKESE---EIEKEISILKKCKSQNIVSYFGSGQQG-DNLWILMEYCSANSI PakH_Ddis TSIAIKEFEIFEANDVEPISKEIQILKKCNNPYVVSYFGSIMLK-NKYWILMDYCSLSSF PakH_C2d_Ddis TSIAIKEFEIFEANDVEPISKEIQILKKCNNPYVVSYFGSIMLK-NKYWILMDYCSLSSF :*** : : :. :.:**.:**:*. ::**:** . ***::.*: .*: PakE_Ddis NDMMKICCDTLDEEQIAVVTLNVLNGLGYLHSKGIVHLDVKAANILLTEDKQIKIADFGV PakF_Ddis RDIIESTEKTLNEAQISFVVKNTLKGLIYLHSQNIIHRDVKAANVLLSEGCDVKIADFGV PakG_Ddis RDMLELTEKSLTEKQISVILQQALKGLHYLHQSNIIHRDIKAANILINEDAIVKLADFGV PakH_Ddis NDIMQSIGKTFKEKEISLILQQSLLGLVYLHSKQIIHRDIKSANILLDETGQVKIADFGV PakH_C2d_Ddis NDIMQSIGKTFKEKEISLILQQSLLGLVYLHSKQIIHRDIKSANILLDETGQVKIADFGV .*::: .:: * :*:.: : * ** ***.. *:* *:*:**:*: * :*:***** PakE_Ddis SQQLQTEY-GQANVYIGSPLYMAPEVILKAPYNSKADIWSLGITLIELAEGRPPNRGLRS PakF_Ddis SEKLNGAL-DQSKEMIGTPLWMAPEVILKKNYDYKADIWSLGITIIEMADGLPPHIDLPP PakG_Ddis SSQLEDSLRGEASQLVGTPLWMAPEIIKRQNYNNKCDIWSLGITAIEMAESFPPLYTMPP PakH_Ddis SQQIQSTF-SKG-SIAGTPYWMAPEILNQTDYNNKIDVWSLGIVAIELADGEPPLSEVNP PakH_C2d_Ddis SQQIQSTF-SKG-SIAGTPYWMAPEILNQTDYNNKIDVWSLGIVAIELADGEPPLSEVNP *.::: .:. *:* :****:: : *: * *:*****. **:*:. ** : . PakE_Ddis MNQLVEIPNMPPPKLSNPKDWSPCFNNFLATCLVKDPVQRPSVIDLLSHDFIKNA--KTT PakF_Ddis MRAMKMVPNWPPPTFAEPKKWSPLLNDFLARCLVKDPEKRASPIDLLCHPFLKKD--RGP PakG_Ddis TRAMLMIPNKPPPTLSKPHHFSKELNDFIGQCCQKDPEKRPSAIELLTHPFLVQNISTPQ PakH_Ddis MRAMYMIGRRPPPTFKDPKKWSPEFVSFVDKCLTKDINERWSPSQLLDHPFIKSA--K-P PakH_C2d_Ddis MRAMYMIGRRPPPTFKDPKKWSPEFVSFVDKCLTKDINERWSPSQLLDHPFIKSA--K-P . : : . ***.: .*:.:* : .*: * ** :* * :** * *: . PakE_Ddis EVLSNLVKQTLSS----------------------------------------------- PakF_Ddis DVLSDLVNQLFKIKKKKIDDLKKQQKHQTSQSSSSSSPQSPNA-----------TVNGGD PakG_Ddis EVLKPLIDECLKKSIKKKKQ--------SPNNDQPPPPQTPNKLSPPDTPLPNVPVLGKN PakH_Ddis DALKELTQMAIKLKSKKRKSI----------GPSVSPKQQPND-----------NNN--- PakH_C2d_Ddis DALKELTQMAIKLKSKKRKSI----------GPSVSPKQQPND-----------NNN--- :.*. * . :. PakE_Ddis ------------------------------------------------------------ PakF_Ddis IGSDGLSTSIISPIPSSPSDELDNCNNSLK---LATSSKGMLSFKGNYTTCRDFQEEEED PakG_Ddis QGLLNKSNGMKKS-HGSSLDEAESMNTFILKSTIGSSSNGSNDTGGDDFDCGTMIL---- PakH_Ddis -----------------------NNNNN---------------------------KPQFL PakH_C2d_Ddis -----------------------NNNNN---------------------------KPQFL PakE_Ddis ------------------------------------------------------------ PakF_Ddis SKHLNNNQDEQDDEQDDEDDDDENEDDEDVDPFSTTIFHGKK-KGSGNGNGGVTSDQDDE PakG_Ddis ------------------KDDTCINGSGNADKISTIPAFIAA---LNKSNGKVIT-QNQQ PakH_Ddis SKLLNNNSNSSNDIGETT---------SGSVIYKPNVFSGSIDTGSVVIHNTITSNNND- PakH_C2d_Ddis SKLLNNNSNSSNDIGETT---------SGSVIYKPNVFSGSIDTGSVVIHNTITSNNND- PakE_Ddis ------------------------------------------------------------ PakF_Ddis EEDEEEDDEEEEEEEEDDDEINEDE-----------EISATGTMVVRKKKNKSTKKSNKK PakG_Ddis QQQQQPIASSLQQSNPIASIVNENQYPNTIEKRGLSSINSNNSLLIGNSGNNKSQNFNNF PakH_Ddis ------------------------------------------------------------ PakH_C2d_Ddis ------------------------------------------------------------ PakE_Ddis ------------------------------------------------------------ PakF_Ddis KNKKNNLSTIGKS-----------------GSGNNLL----HVAPNKPLPITPPFSIS-M PakG_Ddis NNNNNNNNNNNNNNNNNNNNNNNNNNNNEFL----------------------------- PakH_Ddis -------------------------------SGSVVLNSNTVINRSKPLPPPPSYESVIL PakH_C2d_Ddis -------------------------------SGSVVLNSNTVINRSKPLPPPPSYESVIL PakE_Ddis ------------------------------------------------------------ PakF_Ddis TNEFKQLETKLFTYIDSSNQKIVNDIKNEIKQLESSIINKININLQQQLSPILLALEEIK PakG_Ddis --------------INQIKKELILDFNENMKQYINQQLTNLKEEMLKEISKIVIA--NIP PakH_Ddis NDKLKQ------------------------------------------------------ PakH_C2d_Ddis NDKLKQ------------------------------------------------------ PakE_Ddis ------------------------------------------------------------ PakF_Ddis QNQHTTSQPKQMQSKLSA----------TNLNEKKLSSSPPSSNSP-------------- PakG_Ddis QAPIKTSQSVFNQ-QLSAAAIIHPISSSSSSSSSFLNSSPSSSNSSATIFKKFPNPPPTP PakH_Ddis -QQQQQ------------------------------------------------------ PakH_C2d_Ddis -QQQQQ------------------------------------------------------ PakE_Ddis ------------------------------------------------------------ PakF_Ddis -----LTNSVNSSLTTTTTTTTSPVLSRQSSFRSS--GSI-SSSNSS-FRPN-------- PakG_Ddis VLINKLPPSQQSTPVTTTTTTSSPSPSPSPSPSPSPSSPLPSSSTSTVNTPNKPPINYRK PakH_Ddis ---------QQSNQQTTTTTTK-------------------------------------- PakH_C2d_Ddis ---------QQSNQQTTTTTTK-------------------------------------- PakE_Ddis ------------------------------------------------------------ PakF_Ddis -------SAIMSAVNNSSTTTTTNSNSSSSNGGGSGVDISPTMTGRA------------- PakG_Ddis SKELDSTINIFNGLNNNNTNNNNNNNNSNNNNNNNNVIQSPKLNNRPLSPTTPTKQFNNR PakH_Ddis ------------------------QNT--------------------------------- PakH_C2d_Ddis ------------------------QNT--------------------------------- PakE_Ddis ------------------------------------------------------------ PakF_Ddis ------------SPSIMKRFTTSSSSSPLSSSSDGFA----------------------- PakG_Ddis PPSPSKFNNRPPSPSKFNNRPPSPSNRPLSPKNSYNSLEKSNNGSISNNRPLSPKNSLEK PakH_Ddis ---------------IKN------------------------------------------ PakH_C2d_Ddis ---------------IKN------------------------------------------ PakE_Ddis ------------------------------------------------------------ PakF_Ddis FNSNSNSSSSDLKRHVITPE---------------------------------------- PakG_Ddis STTQNNTSSEDISTTTVTVTSEQGGTPITTPMAFLPRPKPSPPPIPMNKSSPKRAPSPSS PakH_Ddis ---KFNTISNTIKCNTILVQ---------------------------------------- PakH_C2d_Ddis ---KFNTISNTIKCNTILVQ---------------------------------------- PakE_Ddis ------------------------------------------------------------ PakF_Ddis -------------------------------------------------------EL--- PakG_Ddis NRRLSSSFTAQSSTASTIAALGKQSSMSPNSPLIKERVPPPLPPPRTTITSSTNSPIKPL PakH_Ddis -------------------------------------------------------DK--- PakH_C2d_Ddis -------------------------------------------------------DK--- PakE_Ddis ------------------------------------------------------------ PakF_Ddis ----------------------NNSN---------------------------------- PakG_Ddis SPLNKSPNSPYVPPRITTSNISNNSNINNNNNNNSNSSSNGSGGTPITLKRASTTISPIM PakH_Ddis ----------------------TLEI---------------------------------- PakH_C2d_Ddis ----------------------TLEI---------------------------------- PakE_Ddis ------------------------------------------------------------ PakF_Ddis --------------------------------------------LVKNKVKMFEDDNSSG PakG_Ddis ISSNSPKVMGSNVNKPLALSRNSTEINLPSSSPSTPQKPNTPSSIPTTPTTPTTNGGSVS PakH_Ddis --------------------------------------------IQKTPMKNLDERNQKI PakH_C2d_Ddis --------------------------------------------IQKTPMKNLDERNQKI PakE_Ddis ----------------------RQSI PakF_Ddis SGSNSPSLSTNSSSTNSNNSVTNIKK PakG_Ddis SKSSTIGR----KTVLQVKSIFSPKK PakH_Ddis VLYSTLGL----ILV--LSVFFKFFK PakH_C2d_Ddis VLYSTLGL----ILV--LSVFFKFFK