CLUSTAL W (1.83) multiple sequence alignment PDHK4_Hsap M------------KAARFVLRSAG-----------------------SL----NGAGLVP PDHK1_Hsap M------------RLARLLRGAAL-AGPGPGLRAAGFSRSFSSDSGSSP----ASERGVP PDHK2_Hsap M------------RWVWALLKNA------------------------S-------LAGAP PDHK3_Hsap M------------RLFRWLLK-----------------------------------QPVP aSWK467_Cele M------------RFSRKLLGPF--------------------------------VGSLA PDHK_Spur MV-----------RLTVRLLAM--------------------------------AKKNMQ PDHK1_Mmus M------------RLARLLRGGTS-VRPLCAVPCASRSLASASASGSGP----ASELGVP PDHK2_Mmus M------------RWVRALLKNA------------------------S-------LAGAP PDHK3_Mmus M------------RLFYRLLK-----------------------------------QPVP PDHK4_Mmus M------------KAARFVMRSAS-----------------------SL----SSASLVP pdhk-2_Cele M------------RFSRKLLGPF--------------------------------VGSLA PDK_Dmel M------------RLFPVRFSAA------------------------SL-----SMASLA YIL042C_Scer MWKIMRSWKCGGMRWAHRQRPSHELLS-------------QL-----SFDQHYKIRSNIE CC1G_15212_Ccin M------------SAGFRI-T-----------------------------------PALW * PDHK4_Hsap REVEHFSRYSPSPLSMKQLLDFGSENAC--ERTSFAFLRQELPVRLAN---ILKEIDILP PDHK1_Hsap GQVDFYARFSPSPLSMKQFLDFGSVNAC--EKTSFMFLRQELPVRLAN---IMKEISLLP PDHK2_Hsap KYIEHFSKFSPSPLSMKQFLDFGSSNAC--EKTSFTFLRQELPVRLAN---IMKEINLLP PDHK3_Hsap KQIERYSRFSPSPLSIKQFLDFGRDNAC--EKTSYMFLRKELPVRLAN---TMREVNLLP aSWK467_Cele KKLDYYSQFQPSSLTIQQYLDFGRIG-T-S-ANSYTFLKNELLVRLAN---IMQEFTLLP PDHK_Spur AQMEYYSKFSPSPLSIKQFMDFGQSKDV-DSAKSFVFLRQELPVRIAN---IMKEINLLP PDHK1_Mmus GQVDFYARFSPSPLSMKQFLDFGSVNAC--EKTSFMFLRQELPVRLAN---IMKEISLLP PDHK2_Mmus KYIEHFSKFSPSPLSMKQFLDFGSSNAC--EKTSFTFLRQELPVRLAN---IMKEINLLP PDHK3_Mmus KQIERYSRFSPSPLSIKQFLDFGRDNAC--EKTSYMFLRKELPVRLAN---TMREVNLLP PDHK4_Mmus REVELFSRYSPSPLSMKQLLDFGSENAC--ERTSFAFLRQELPVRLAN---ILKEIDILP pdhk-2_Cele KKLDYYSQFQPSSLTIQQYLDFGRIG-T-S-ANSYTFLKNELLVRLAN---IMQEFTLLP PDK_Dmel KMLDFYSGFNPSPLSIKQFMDFGQ-NAC--EKKSYIFLRKELPVRLAN---IMKEIALLP YIL042C_Scer LLIQDYASKPIAPLNYEYFLQYRP-PLT--KKEEYMLTIKTINLLLSLTCKRLNAIQRLP CC1G_15212_Ccin DKIHHFASFPQTGVSLQQMVLFGQNPSQGTLLKASQFLSEELPVRLAH---RVKELDELP :. :: : :. : : : : : : : :: :. . ** PDHK4_Hsap TQLVNTSSVQLVKSWYIQSLMDLVEFHEKS------------------------------ PDHK1_Hsap DNLLRTPSVQLVQSWYIQSLQELLDFKDKS------------------------------ PDHK2_Hsap DRVLSTPSVQLVQSWYVQSLLDIMEFLDKD------------------------------ PDHK3_Hsap DNLLNRPSVGLVQSWYMQSFLELLEYENKS------------------------------ aSWK467_Cele PKLLQMPSSKMVSNWYAESFEDLLLFEAS------------------------------- PDHK_Spur EKLLQMPSVRMVQGWYQQTFEELLEYVEKT------------------------------ PDHK1_Mmus DNLLRTPSVQLVQSWYIQSLQELLDFKDKS------------------------------ PDHK2_Mmus DRVLGTPSVQLVQSWYVQSLLDIMEFLDKD------------------------------ PDHK3_Mmus DNLLNRPSVGLVQSWYMQSFLELLEYENKS------------------------------ PDHK4_Mmus DRLVNTPSVQLVKSWYIQSLMDLVEFHEKS------------------------------ pdhk-2_Cele PKLLQMPSSKMVSNWYAESFEDLLLFEAS------------------------------- PDK_Dmel DNLLHTRSVSEVSSWYVKSFEDVLVYEKA------------------------------- YIL042C_Scer YNAVINPHIERTNSLYLKSLQTLLSIAYPYEL---------------------------- CC1G_15212_Ccin HNLSDMPSIKRVKNWYAQSFEELINFPHPQLPPEIRQALITSRSDELALPESKPNPSLID . ... * ::: :: PDHK4_Hsap ------------------------------------------PDDQKALSDFVDTLIKVR PDHK1_Hsap ------------------------------------------AEDAKAIYDFTDTVIRIR PDHK2_Hsap ------------------------------------------PEDHRTLSQFTDALVTIR PDHK3_Hsap ------------------------------------------PEDPQVLDNFLQVLIKVR aSWK467_Cele ------------------------------------------DSSPEQVARFNDQLTVVL PDHK_Spur ------------------------------------------EEEDPVLLRYINQLTTIR PDHK1_Mmus ------------------------------------------AEDAKTIYEFTDTVIRIR PDHK2_Mmus ------------------------------------------PEDHRTLSQFTDALVTIR PDHK3_Mmus ------------------------------------------PEDPRVLDNFLNVLINIR PDHK4_Mmus ------------------------------------------PEDQKALSEFVDTLVKVR pdhk-2_Cele ------------------------------------------DSSPEQVARFNDQLTVVL PDK_Dmel ------------------------------------------EPTHDNLQKFVADLDLIR YIL042C_Scer ------------------------------------------HNPPKIQAKF----TELL CC1G_15212_Ccin TIYGSSPSNGNGNGGNGFNKLRLRVPMERRYYANTSNITHWPPEVQDYNKRFTKLLEHIK : : PDHK4_Hsap NRHHNVVPTMAQG----------------------------------------------- PDHK1_Hsap NRHNDVIPTMAQG----------------------------------------------- PDHK2_Hsap NRHNDVVPTMAQG----------------------------------------------- PDHK3_Hsap NRHNDVVPTMAQG----------------------------------------------- aSWK467_Cele KRHAHVVETMAEG----------------------------------------------- PDHK_Spur NRHVNVVETMAQG----------------------------------------------- PDHK1_Mmus NRHNDVIPTMAQG----------------------------------------------- PDHK2_Mmus NRHNDVVPTMAQG----------------------------------------------- PDHK3_Mmus NRHNDVVPTMAQG----------------------------------------------- PDHK4_Mmus NRHHNVVPTMAQG----------------------------------------------- pdhk-2_Cele KRHAHVVETMAEG----------------------------------------------- PDK_Dmel NRHNDVVQTMAQG----------------------------------------------- YIL042C_Scer DDHEDAIVVLAKG----------------------------------------------- CC1G_15212_Ccin SRHDPTVTTVAQGRSFRLPAFFGVLGVFWASGLGSVPLPSLYSRSMDPFVICEEHALTEL . * .: .:*:* PDHK4_Hsap ------------------------------------------------IIEYKDACT--V PDHK1_Hsap ------------------------------------------------VIEYKESFG--V PDHK2_Hsap ------------------------------------------------VLEYKDTYG--D PDHK3_Hsap ------------------------------------------------VIEYKEKFG--F aSWK467_Cele ------------------------------------------------LIELRESDG--V PDHK_Spur ------------------------------------------------ILEMRESYK--V PDHK1_Mmus ------------------------------------------------VTEYKESFG--V PDHK2_Mmus ------------------------------------------------VLEYKDTYG--D PDHK3_Mmus ------------------------------------------------VIEYKEKFG--F PDHK4_Mmus ------------------------------------------------ILEYKDTCT--V pdhk-2_Cele ------------------------------------------------LIELRESDG--V PDK_Dmel ------------------------------------------------VIEMKENEGGQV YIL042C_Scer ------------------------------------------------LQEIQSCYP--- CC1G_15212_Ccin SIPFTLPQCLHAPLLGFLSLSLTHALASRLPPTFLVTGPRLPRTDLLCVLEWKRSQN--A : * : PDHK4_Hsap DPVTNQNLQYFLDRFYMNRISTRMLMNQHILIFSD-S--QTGNPSHIGSI---------- PDHK1_Hsap DPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGKGSPSHRKHIGSI---------- PDHK2_Hsap DPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGST--NPAHPKHIGSI---------- PDHK3_Hsap DPFISTNIQYFLDRFYTNRISFRMLINQHTLLFGGDT--NPVHPKHIGSI---------- aSWK467_Cele DIASEKGIQYFLDRFYINRISIRMLQNQHLVVFGN-V--LPESPRHVGCI---------- PDHK_Spur DQHEENNVQYFLDRFYISRISIRMLINQHTLMFGQ-I--PTTHPLLVGSI---------- PDHK1_Mmus DPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKG--SPSHRKHIGSI---------- PDHK2_Mmus DPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGST--NPAHPKHIGSI---------- PDHK3_Mmus DPFISSNIQYFLDRFYTNRISFRMLINQHTLLFGGDT--NPAHPKHIGSI---------- PDHK4_Mmus DPVTNQNLQYFLDRFYMNRISTRMLMNQHILIFSD-S--KTGNPSHIGSI---------- pdhk-2_Cele DIASEKGIQYFLDRFYINRISIRMLQNQHLVVFGN-V--LPESPRHVGCI---------- PDK_Dmel DAPTESSIQYFLDRLYMSRISIRMLINQHTLLFGG-N--PHAGGRHIGCL---------- YIL042C_Scer ----KFQISQFLNFHLKERITMKLLVTHYLSLMAQNK--GDTNKRMIGIL---------- CC1G_15212_Ccin RH-IGLDIQAWLDRFYMSRIGIRFLIGQHVALN---T--QQAHEDYVGIICTKAVRVPPS :. :*: .** ::* :: : :* : PDHK4_Hsap ------------------------------------------------------------ PDHK1_Hsap ------------------------------------------------------------ PDHK2_Hsap ------------------------------------------------------------ PDHK3_Hsap ------------------------------------------------------------ aSWK467_Cele ------------------------------------------------------------ PDHK_Spur ------------------------------------------------------------ PDHK1_Mmus ------------------------------------------------------------ PDHK2_Mmus ------------------------------------------------------------ PDHK3_Mmus ------------------------------------------------------------ PDHK4_Mmus ------------------------------------------------------------ pdhk-2_Cele ------------------------------------------------------------ PDK_Dmel ------------------------------------------------------------ YIL042C_Scer ------------------------------------------------------------ CC1G_15212_Ccin PSPFDTLFHFFGTSSAIEPHTDETAFLFLFRMRLVVVVVDVIVMDTLVVVMRSRYLDSTR PDHK4_Hsap -------------------------------DPNCDVVAVVQDAFECSRMLCDQYYLSSP PDHK1_Hsap -------------------------------NPNCNVLEVIKDGYENARRLCDLYYINSP PDHK2_Hsap -------------------------------DPNCNVSEVVKDAYDMAKLLCDKYYMASP PDHK3_Hsap -------------------------------DPTCNVADVVKDAYETAKMLCEQYYLVAP aSWK467_Cele -------------------------------DPACDVESVVYDAFENARFLCDRYYLTSP PDHK_Spur -------------------------------DPSCDIVAVIRDAYDSAKYLCDQYYLASP PDHK1_Mmus -------------------------------NPNCDVVEVIKDGYENARRLCDLYYVNSP PDHK2_Mmus -------------------------------DPNCSVSDVVKDAYDMAKLLCDKYYMASP PDHK3_Mmus -------------------------------DPTCNVADVVKDAYETAKMLCEQYYLVAP PDHK4_Mmus -------------------------------DPNCDVVAVVQDAFECAKMLCDQYYLTSP pdhk-2_Cele -------------------------------DPACDVESVVYDAFENARFLCDRYYLTSP PDK_Dmel -------------------------------DPACDLSDVVRDAYENARFLCDQYYLTSP YIL042C_Scer -------------------------------HRDLPIAQLIKHVSDYVNDICFVKFNTQR CC1G_15212_Ccin LGRCDVFGIWFCLDLGGYGAISRTFYTCAVISGLWNVHDIVQEAIENARFVCEEHYAMFK : :: . : . :* : PDHK4_Hsap ELKLTQVNGKFP-DQPIHIVYVPSHLHHMLFELFKNAMRATVEHQEN-Q-PSLTPIEVIV PDHK1_Hsap ELELEELNAKSP-GQPIQVVYVPSHLYHMVFELFKNAMRATMEHHAN-R-GVYPPIQVHV PDHK2_Hsap DLEIQEINAANS-KQPIHMVYVPSHLYHMLFELFKNAMRATVESHES-S-LILPPIKVMV PDHK3_Hsap ELEVEEFNAKAP-DKPIQVVYVPSHLFHMLFELFKNSMRATVELYED-RKEGYPAVKTLV aSWK467_Cele SMKLEMHNAVEK-GKPISIVAVPSHLYHMMFELFKNAMRATVEYHGV-D-DDLPDIKVYV PDHK_Spur DIDVRWIDARDG-SDSIRMVYVPSHLYHIMFELLKNAMRAVMEHKGP-SASEFPPIGILV PDHK1_Mmus ELELEELNAKSP-GQTIQVVYVPSHLYHMVFELFKNAMRATMEHHAD-K-GVYPPIQVHV PDHK2_Mmus DLEIQEVNATNA-NQPIHMVYVPSHLYHMLFELFKNAMRATVESHES-S-LTLPPIKIMV PDHK3_Mmus ELEVEEFNAKAP-NKPIQVVYVPSHLFHMLFELFKNSMRATVELHED-KKEGYPAVKTLV PDHK4_Mmus ELNLTQVNGKFP-GQPIHIVYVPSHLHHMLFELFKNAMRATVEHQEN-R-PSLTPVEATV pdhk-2_Cele SMKLEMHNAVEK-GKPISIVAVPSHLYHMMFELFKNAMRATVEYHGV-D-DDLPDIKVYV PDK_Dmel ALEIQQHSSEPGDNLPIRTVYVPSHLYYMLFELFKNSMRAVVEHHGHDNNDTLPPLKVAI YIL042C_Scer ----TPVLIHPP-SQDITFTCIPPILEYIMTEVFKNAFEAQIALG----KEH-MPIEINL CC1G_15212_Ccin GPPVQLICP---P--SLTFAYVPGHLSHICFELLKNSLRAVVERYGVDAEDHFPPIKVIV : . :* * :: *::**::.* : : : PDHK4_Hsap VL-GKEDLTIKISDRGGGVPLRIIDRLFSYTYSTAPTPV-MDN-------SRNAPLAGFG PDHK1_Hsap TL-GNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPR-VET-------SRAVPLAGFG PDHK2_Hsap AL-GEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQ-PG--------TGGTPLAGFG PDHK3_Hsap TL-GKEDLSIKISDLGGGVPLRKIDRLFNYMYSTAPRPS-LEP-------TRAAPLAGFG aSWK467_Cele VK-GQEDLSIKICDRGGGVSRTILERLYNYMYSTAPPPP-RDG-------T-QAPLAGYG PDHK_Spur TK-GKEDVTIKVSDEGGGIPKSEIDLLFNYMYSTAPAPP-KPG------VSIIPPLAGYG PDHK1_Mmus TL-GEEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPR-VET-------SRAVPLAGFG PDHK2_Mmus AL-GEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQ-PG--------TGGTPLAGFG PDHK3_Mmus TL-GKEDLSIKISDLGGGVPLRKIDRLFNYMYSTAPRPS-LEP-------TRAAPLAGFG PDHK4_Mmus VL-GKEDLTIKISDRGGGVPLRITDRLFSYTYSTAPTPV-MDN-------SRNAPLAGFG pdhk-2_Cele VK-GQEDLSIKICDRGGGVSRTILERLYNYMYSTAPPPP-RDG-------T-QAPLAGYG PDK_Dmel CK-GKEDICVKISDQGGGIPRSQTDQLFKYMYSTAPQPS-KSD-------LHTVPLAGYG YIL042C_Scer LKPDDDELYLRIRDHGGGITPEVEALMFNYSYSTHTQQS-ADSESTDLPGEQINNVSGMG CC1G_15212_Ccin VE-GKEDITIKISDEGGGIARSAIPLIWTYMYTTMEHQTSLDEDF--QASDFKAPMAGFG ..::: ::: * ***:. ::.* *:* ::* * PDHK4_Hsap YGLPISRLYAKYFQGDLNLYSLSGYGTDAIIYLKALSSESIEKLPVFNKSAFKHYQMSSE PDHK1_Hsap YGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTDSIERLPVYNKAAWKHYNTNHE PDHK2_Hsap YGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQE PDHK3_Hsap YGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLKALSSESFERLPVFNKSAWRHYKTTPE aSWK467_Cele YGLPLSRLYARYFLGDLFLVSMEGHGTDACIYLKAVPVEASEVLPIYSTSSRRNLTMGPQ PDHK_Spur YGLPISRLYAKYFHGDLTLSSMDGYGTDAVVYLKVLSSEASELLPIYNSAVSRYYKTPTP PDHK1_Mmus YGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTESVERLPVYNKAAWKHYKANHE PDHK2_Mmus YGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQE PDHK3_Mmus YGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLKALSSESFERLPVFNKSAWRHYKTTPE PDHK4_Mmus YGLPISRLYAKYFQGDLNLYSMSGYGTDAIIYLKALSSESVEKLPVFNKSAFKHYQMSSE pdhk-2_Cele YGLPLSRLYARYFLGDLFLVSMEGHGTDACIYLKAVPVEASEVLPIYSTSSRRNLTMGPQ PDK_Dmel YGLPISRLYARYFHGDIVLLSCEGFGTDAIIYLKALSDEANELLPIFNKTSSKFYRATVP YIL042C_Scer FGLPMCKTYLELFGGKIDVQSLLGWGTDVYIKLKGPSKTA-------------------- CC1G_15212_Ccin YGLPLSRLYARYFGGDLRLIAMDGFGTDVYIHLNRLSS-SREPL---------------- :***:.: * . * *.: : : * ***. : :: . : PDHK4_Hsap ADDWCIPSREPKNLAKE----------VAM PDHK1_Hsap ADDWCVPSREPKDMTTF----------RSA PDHK2_Hsap AGDWCVPSTEPKNTSTY----------RVS PDHK3_Hsap ADDWSNPSSEPRDASKYKAKQDKIKTNRTF aSWK467_Cele VADWSHH--VPGQGNRP----------AQS PDHK_Spur ASDWSTPGYFIRNYTTKR---------YGK PDHK1_Mmus ADDWCVPSREPKDMTTF----------RSS PDHK2_Mmus AGDWCVPSTEPKNTSTY----------RVS PDHK3_Mmus ADDWSNPSSEPRDASKYKAKQDKIKSNRTF PDHK4_Mmus ADDWCIPSREPKNLAKEK---------LAV pdhk-2_Cele VADWSHH--VPGQGNRP----------AQS PDK_Dmel TGDWSNQVKYAKKKKTSA---------VSQ YIL042C_Scer ---------------LL----------SKK CC1G_15212_Ccin -----------------------------P