CLUSTAL W (1.83) multiple sequence alignment Pitslre_Dmel MVNSSGSE---------------------------------------------------- B0495.2_Cele MSDHLGSS---------------------------------------------------- ZC504.3_Cele MRCNKQIHQFMYINLQPHITVQVYIFDLFHNTFPLSSLCAHQLRVCLHTQRSVFAYFPRG DDB0216376_Ddis MSNIQENE---------------------------------------------------- DDB0229427_Ddis ------------------------------------------------------------ 13176_Tthe MSDQQIDK---------------------------------------------------- PITSLRE_Spur MEEEEEEE---------------------------------------------------- CC1G_03659_Ccin MSASAGP----------------------------------------------------- AqueK105_Aque MITYLLLG---------------------------------------------------- Pitslre_Dmel ---------------DGQ----------------------------LRSPNDVHYHSR-G B0495.2_Cele ---------------HDEGELSDESHKKSQRASSSDEPNPAKSNKGLESKMRESILSR-L ZC504.3_Cele LIFGNTCFDSFYCLLSHSYFVSDSFC----------------YHFCVLKVIMSNYSTNGS DDB0216376_Ddis ---------------NK------------------------------------------- DDB0229427_Ddis ------------------------------------------------------------ 13176_Tthe ---------------QR------------------------------------------- PITSLRE_Spur ---------------E-------------------------------------------- CC1G_03659_Ccin ------------------------------------------------------------ AqueK105_Aque ---------------DEEAFFSKDI------------PS----KGSLKSTVSRSYRSR-D Pitslre_Dmel -EE---DEHEGDADALYIQPPQASRESGSGPRRE-KKKHSRERRRHKERDDVGGAALALE B0495.2_Cele SKRKNSES-DDDTTE----QRFSIQP-----KNAQKAKEDRYRDKERDKK---------- ZC504.3_Cele RKIRISNS-DDDSRE----TRFSIQP-----RNSHKTKEERYRDKEKERD---------- DDB0216376_Ddis ETCNIKEN-EN---------------------------------KE-------------- DDB0229427_Ddis ------------------------------------------------------------ 13176_Tthe EEAHFNEN-ES-----------------------SDSNFDHIEDNEQDE----------- PITSLRE_Spur ---------------------------------K-EE---EYERK----E---------- CC1G_03659_Ccin -------------------------------STP-SKKRSKWEDG---DD---------- AqueK105_Aque -KGSYGDSHQDDIDTYRREMKRQAPP-----TTD-EGRQTERRHGDRRRD---------- Pitslre_Dmel RDHRYDYRSREEHYHHHQRER--SSNAAAAYAKHHLGHAYHYPQPPQQQQQPLPPAPSYA B0495.2_Cele -----------RE-KDKRDDR-R-D----------------------------------- ZC504.3_Cele -----------HE-RHHDRER-R-D----------------------------------- DDB0216376_Ddis ------------------------------------------------------------ DDB0229427_Ddis ------------------------------------------------------------ 13176_Tthe ------------------------------------------------------------ PITSLRE_Spur ---------IEELEEEHEVEEENAS----------------------------------- CC1G_03659_Ccin -----------DE-LDHGQ----------------------------------------- AqueK105_Aque -----------NEGRHHGRSV--------------------------------------- Pitslre_Dmel AHHYHHHQHLSGARAAPREYHSYPSGYHSGSRHGDYPMEEPTRRSSKYAESKDAESLEQD B0495.2_Cele ---------------------------------------------VRG----P-D----- ZC504.3_Cele ---------------------------------------------DRYRKVDSRD----- DDB0216376_Ddis ------------------------------------------------------------ DDB0229427_Ddis ------------------------------------------------------------ 13176_Tthe ------------------------------------------------------------ PITSLRE_Spur -------------------------------------------SSEEEEESDDEE----- CC1G_03659_Ccin ------------------------------------------------------------ AqueK105_Aque ------------------------------------------------------------ Pitslre_Dmel LRSRLLKKRHNYVKDYETEENYEHRVERSDRREGGRKERERTVRSTHK-QNRHDRVIE-L B0495.2_Cele -----------------------------------ARQKDRDFKGRQERSGRDQKVHEHR ZC504.3_Cele -----------------------------------HRDRNRRSPA-GSRTY--CRDEPDR DDB0216376_Ddis ------------------------------------------------------------ DDB0229427_Ddis ------------------------------------------------------------ 13176_Tthe ------------------------------------------------------------ PITSLRE_Spur ------------------------------------------------------------ CC1G_03659_Ccin -----------------------------------------------------PQIHPQK AqueK105_Aque ----------------------EHKSKRKSRKETTNPKRERRTRSRSPIYSTQSRSHSDR Pitslre_Dmel LDSPEQEHHHQHQHKSHRSKWREEVEVIRRKVPEDLELLARREKLLAAERESRQRKQTAR B0495.2_Cele HHHHHRKHETDGHRTNRSNRDR------------------------SSERDSEK------ ZC504.3_Cele RR----NNHSDRNR-----RDR------------------------SSERDRD------- DDB0216376_Ddis ------------------------------------------------------------ DDB0229427_Ddis ------------------------------------------------------------ 13176_Tthe ------------------------------------------------------------ PITSLRE_Spur -EDDEEEESSEAESESEEE---EEVEEIKEASSS--------------------EEEGSA CC1G_03659_Ccin RRVKAKSSSTPAQDS--------------------------------------------- AqueK105_Aque REPRSQYSHSDSQSKSHSGAWS------------------------SSHRHTHSHK---- Pitslre_Dmel EELEARRELLRERNEHSDALSPTTVAASVTAGLNIHVKRKSKPDNYEKEIKLKKRREDDI B0495.2_Cele -----------------------------------------HKRHI-------------- ZC504.3_Cele ------------------------------------------------------------ DDB0216376_Ddis ------------------------------------------------------------ DDB0229427_Ddis ------------------------------------------------------------ 13176_Tthe ------------------------------------------------------------ PITSLRE_Spur EEGEAS-AGDLEEGEHKDS--------------------------DDEEEEEEEEEEEEE CC1G_03659_Ccin ------------------------------------------------------------ AqueK105_Aque -------------------------------------------SEYDRGEGGSGGRRDVY Pitslre_Dmel EVIRDDDDEESEESDSNEEV-PEQD-SEGSATES----------GSEDSYASKKKSKIKS B0495.2_Cele --DRHKKSS-TTSPDNDKSP-HK-K-SKHTDVPADAKLFDRILDPN-YKKKDDDVLV--I ZC504.3_Cele --NRSSKSK-TKSPDSLRSK-SSRKSQTPNHLPDDGKLFDRILDPN-YKKKEKTVME--V DDB0216376_Ddis ------IL-----------------------------------KEN-FKN---------- DDB0229427_Ddis ------------------------------------------------------------ 13176_Tthe ---QKNEIN-LN------------------------------------------------ PITSLRE_Spur EEEEEEES-EEEESDSDSESQSEEE-SEKSVSEV----------DHEEMQQEEEKAKVKQ CC1G_03659_Ccin -----GRGT-TTAADHGHSL-S-KR-SRSVY----------------------------- AqueK105_Aque RLVRDLESS-SSGSDSDEGV-VSKE-ATPTRLKD----------GTEESKKESPKKT--W Pitslre_Dmel KSQLEDDDE---DLPLPD----------SPLSVGELYKSPKQRQRSRSVSSKSSSQSS-- B0495.2_Cele EDVEMSPIEILEEKEEKEIVEFTIDSPAGPK--------------------------KYS ZC504.3_Cele EDVEMSPVEMLDEE---EVSTFTFDDACGPV---------------RPSNEP---EEKDY DDB0216376_Ddis --------------KE-------------------------------------------- DDB0229427_Ddis ------------------------------------------------------------ 13176_Tthe -----------LDDEERK------------------------------------------ PITSLRE_Spur EK--ETD----------------------------------------------------- CC1G_03659_Ccin ------------------------------------------------------------ AqueK105_Aque KDIMYSDSE---EEEEGE----------SPL---------------RKSASP---RE--- Pitslre_Dmel ------RSSRSRSRSRSQSSLEDEVDRQDVGADASPSSSTRSEER---GM--TQEQPEEK B0495.2_Cele KFESDPESDHDDTKPKSPGKAEDDDDVIEVLDDALHSDDDADSDEDKYLKTPEDREWEEM ZC504.3_Cele KSEGDPES--RPATPKTPLTPDYLENTIVSLNETLSDDEDKGP-DDKYGKTPDKEQWESM DDB0216376_Ddis ------------------------------------------------------------ DDB0229427_Ddis ------------------------------------------------------------ 13176_Tthe ----------------------------------------------------------IL PITSLRE_Spur ---------SSKIYVHAKSKFDDD----SPSPIRELPGLV-HEEE----------EIENE CC1G_03659_Ccin ------------------------------------------------------------ AqueK105_Aque -------SDQSDS-------RQGEDDVKDVSATPPLAESVKKEDE---P---AQPTAESA Pitslre_Dmel PEEKLKEKQKSLEEQIPCD----DKGIPLPNYYPGVQGCRSVEEFQCLNRIEEGTYGVVY B0495.2_Cele TETEQRLHKEAMKKRASM--KQKTLIAQLPVFYPGLMGCRNIDEYECVNRVDEGTFGVVY ZC504.3_Cele TENEQKLHRDAMKKRREQ--RHREAVSKLPVYYPGLRGCQHISEYVILNVIAEGTYGEVF DDB0216376_Ddis ----------------------KQYFSSLR---SPYSACRSVDCFKKLYTINEGAFGVVY DDB0229427_Ddis --------------------------------------MRSVLSFEKLDSIGEGTYGIVS 13176_Tthe RKHSQEL---SAEKKLSL--------LRKRKICGLLEGCDSVDNYQKLNKIHEGVYGVVY PITSLRE_Spur VEDQSD--TEYLQDSPVA--SPVELEETLPPYLPAIQGCRSVEEFQCLNRIAEGTYGVVY CC1G_03659_Ccin --------------------------VPERTRHPAIQSSRSVSCYERLNQIEEGSYGVVF AqueK105_Aque VEIKVSSAT---PPGGPVSPSPPPSPHEEVLYLPALMGCRSVECYEWLNRIEEGTYGVVF : : : : ** :* * Pitslre_Dmel RAKDKRTNEIVALKRLKME--KEKEGFPITSLREINTLLK-GQHPNIVTVREIVVGSNMD B0495.2_Cele RGKDKRTDEIVALKRLKME--KEKEGFPITALREINMLLKAGNHPNIVNVKEILLGSNMD ZC504.3_Cele RGKNTRTDEVVALKRFKME--KEKEGFPITALREINMLLKAGAHENIVNVKEILVGSTKT DDB0216376_Ddis CAQDKETEEIVALKKIKME--REREGIPITSVREIKVLME-LKHDNIVQIKEIVLGKNIN DDB0229427_Ddis KGRDKETGRIVALKKVKIG-QQDKDGIPLTSLREIQILKE-IKHPNIVSLLEVVIGSTGD 13176_Tthe RAVDKLTGEIIAIKKTKIDRKKEKEGFPITSIREFNILMA-LRHENIVAVKRVVMGTDLD PITSLRE_Spur RANEKKKNDIVALKRLKME--KEKEGFPITSLREISTLLK-AQHRNIVTVREIVVGSNMD CC1G_03659_Ccin RARDRQTGDIVALKKLKLD--EEKNGFPITALREIYALMT-CQHENVVRIREVVLPPPLS AqueK105_Aque RARDIRTDEIVALKKLKME--KEREGFPITSLREISTLLK-ANHENIVNVREIVVGSNMD . : . ::*:*: *: .:::*:*:*::**: * * *:* : .::: Pitslre_Dmel KIFIVMDYVEHDLKSLMETMKNR-KQSFFPGEVKCLTQQLLRAVAHLHDNWILHRDLKTS B0495.2_Cele KIYMAMEFVEHDMKSLLDTMSRR-NKRFSIGEQKTLLQQLLSGIEHMHKLWILHRDLKTS ZC504.3_Cele EVYMAMEYVEHDVKSLIDKMRSR-NQRFKTGQQKTLMSQLLSGIEHMHKLWILHRDLKTS DDB0216376_Ddis SIFMAMEFIDHDLRGLMEVI----KKPFLPSEIKTLIQQLLNGVSYMHDNWVIHRDLKTA DDB0229427_Ddis KIYLVFEYLEHDVASLIDNI----NKPFKLSEIKCFLLQLLRAVEYLHSHWIIHRDLKCS 13176_Tthe SIYMIMEYMEHELKDVIENH----HDEFQEPQIKSLVQQLLLGMDFLQKKKIMHRDLKTS PITSLRE_Spur KIYIVMDYVEHDLKSLMETM----KQPFTIGETKCLILQLLRGVHHLHDNWILHRDLKTS CC1G_03659_Ccin T----------DAPSALHLASIRLIPPSLDEEFKTLMMQLLSAVHHCHQNWILHRDLKTS AqueK105_Aque KIFIVMDYVEHDLKSLMETM----KQPFLEGEVKTLLIQLLKAVHHLHDNWIIHRDLKTS : . :. : * : *** .: . :. ::***** : Pitslre_Dmel NLLLSHKGILKVGDFGLAREYGSPI-----KKYTSLVVTLWYRAPELLLCSPVYSTPIDV B0495.2_Cele NLLMSHKGILKIADFGLAREYGDPL-----KKFTSIVVTLWYRSPELLLGTRLYSTPVDM ZC504.3_Cele NLLISHSGILKIADFGLAREYGEARDIEKRMKLTPIVVTLWYRSPELLLEPKTYSTPVDM DDB0216376_Ddis NLLYTNKGVLKIADFGLAREYGSPL-----KPLSKGVVTLWYRAPELLLDTEIYTPAIDI DDB0229427_Ddis NLLYGNNGNLKLADFGLARKFGYPI-----ESITPCMVTLWYRSPELLLGCQKYSTAVDL 13176_Tthe NILYNNKGQLKICDFGLGRRWQG-N-----KPYTLNVVTMWYRAPEVLLGQDKYTTALDM PITSLRE_Spur NLLLNHQGCLKIGDFGLAREYGSPI-----KPYTSIVVTLWYRAPELLLGTKVYSTPIDM CC1G_03659_Ccin NLLMNNRGTIKVADFGLARRYGDPVG---LGGLTQLVVTLWYRAPEILLGATEYSTAVDM AqueK105_Aque NLLLSHKGILKVADFGLAREYGSPL-----KNYTPIVVTLWYRAPELLLGAKEYSTAIDV *:* : * :*: ****.*.: : :**:***:**:** *:..:*: Pitslre_Dmel WSVGCIFAEFLQMLPLFPGKSEIDELNRIFKELGTPNEKIWPGYTELPAVKNMLSQNSQF B0495.2_Cele WSVGCIMAEFILLKPLFPGRGELEQIKKIFMEMGTPTESIWPGVTELDGWKAL-----TF ZC504.3_Cele WSIGCIMAEFIMMKPMFQGDSEPNQVHQIFQMMGTPTEQIWPDIKELKVWNMV-----EF DDB0216376_Ddis WSVGCIFAEIISKEVLLQGSSEIDQMDKIFKLFGTPTEKSWPAFFKLPLAKYF-----NL DDB0229427_Ddis WSIGSIFGELLIGRPLITGNNEVDQIMRIFNLLGEPNEQIWPGFSSLPNFKRLN----NI 13176_Tthe WSVGCIFGELITKDQLFKGKNETNQIECIFNAMGGPTERSWPGWTEFKHSKLF-----KD PITSLRE_Spur WSVGCIFAEFLTIKPIFNGRSEIDQLNRIFKELGTPSEKIWPGYNELPAVKKT-----TF CC1G_03659_Ccin WSVGCIFAELLLKEPLFQAKGELELISMIFKLLGPPTKNSWPEYFDLPMAKTI-----AL AqueK105_Aque WSVGCIFAELLQHKPLFMGKSEIDELNLIFKELGVPNESIWPGFGELPVAKKV-----QF **:*.*:.*:: :: . .* : : ** :* *.: ** .: : Pitslre_Dmel TEYPVS-QLRKHFQ--EKTSEMGLSLLQGLLTYDPKQRLSADAALKHGFFKELPLPIDPS B0495.2_Cele EKYPYN-QLRKRFLAGRLLNDTGFKLLNGLLTLDPKNRFSATQALDHEWFTEEPYPVPPE ZC504.3_Cele PPVKPG-QLRRIFKGEKLVNETGFDLLNGMLCLNPANRLTASEALQHDWFSEHPKAVPPE DDB0216376_Ddis TDQPYN-NLKSKFP---HITDNAFDLLNKLLELNPEARISASDALKHPYFFENPQPRDPL DDB0229427_Ddis PHQPYN-NLRELVP---TISDTAFDLLNQLLTYDPTKRITASDAIKHPFFYENPFPQSIE 13176_Tthe RNYPSECTLNEKIG--NRISQTGYKLLCQMLTLNPKERITATKALQDPWFKEEPLPAKLE PITSLRE_Spur AHHPYN-NLRNRFG--TYLTDVGFELLNRFLTYDPVRRISAEDALKHPYFSESPQPISEN CC1G_03659_Ccin PSPQPH-QFRSKFP---YLTTNGLDLLMCLLTYDPERRITAEEALQHPYFTESPLPKHPD AqueK105_Aque TQQPLN-NLRKRFP---MITKNGFVLLNKFFAYDPKRRVTAEDALKHEYFEESPLPVDPS :. . . . ** :: :* *.:* *:.. :* * * . Pitslre_Dmel MFPTWPAKSELGARKAQASSPKPPSGGSQFKQLGR-DEPIIVGPGNKLSSGIITGNKKSH B0495.2_Cele EFPTFPAKSEQNKAP-PPAKQKQ----Q-ENRISH-VDPE-------------------- ZC504.3_Cele DLPVYPAKSELNAAP-PENRRKN----RLEALLAD-EEPE-------------------- DDB0216376_Ddis LMPTWPSSHK-------------------------------------------------- DDB0229427_Ddis MMPKFPTISKSFKNQNKKQNNNFNN-FVQNNQTNQNNQTN-------------------- 13176_Tthe DMPKFKPLNEISREE-RKKL-------KLNNQQAQ-QQAQ-------------------- PITSLRE_Spur MFPTWPAKSEMVR-TNKPRSPQAPEGGQQFAKLEK-EEE--------------------- CC1G_03659_Ccin LFGSFPSVAAGEKRRVVPDSPSAPARAANY--K--------------------------- AqueK105_Aque MFPTWPAKSEMTKKSVRPKSPTAPEGGAFFFNQ--------------------------- : : . Pitslre_Dmel GAGGSSASTGFVLNAGITQRQLAMGPGF-----SLKF B0495.2_Cele -------TAKLLKQ-FEVRPEQVKPGGFSLKFDPTRF ZC504.3_Cele -------RAALLRQ-FNVKAEQLKPSGF-----QLRG DDB0216376_Ddis -----------------------------------KT DDB0229427_Ddis -------QNNQTNQ-NNKTSQNNNMDSY-----KYSK 13176_Tthe -------Q-------------------S-----PIKE PITSLRE_Spur -------DSGFRMA-LPTQGSSAASAGF-----SLKF CC1G_03659_Ccin ------------------------MITE-----FDIP AqueK105_Aque ------------------------KVLE-----LLMN