CLUSTAL W (1.83) multiple sequence alignment PKCh_Hsap MSSG---TMKFNGYLRVRIGEAVGLQPTRWSLRHSL--FKK-GHQLLDPYLTVSVDQVRV PKCe_Hsap M-------VVFNGLLKIKICEAVSLKPTAWSLRHAV--GPRPQTFLLDPYIALNVDDSRI Pkc98E_Dmel M---------FTGKLQIKVCEASGLRPTDFQKRHNLTFGKLADEQLIDPYVSIDVDESHF PKCh_Mmus MSSG---TMKFNGYLRVRIGEAVGLQPTRWSLRHSL--FKK-GHQLLDPYLTVSVDQVRV PKCe_Mmus M-------VVFNGLLKIKICEAVSLKPTAWSLRHAV--GPRPQTFLLDPYIALNVDDSRI kin-13_Cele M--------LFTGTVRVRVLEARQLRPTEWSRRFRQ--DE-AATAAIDSYVNVDWDEYHI PKCe_Spur M--------A-------------------------------------------------- AqueK018_Aque MAGAGGNPDTFTGLVSMTILEAQNLKSVTLPGGHKL--SN----KDFDPYCVVDFDDIYF * PKCh_Hsap GQTSTKQKTNKPTYNEEFCA-NVTDGGHLELAVFHETPLGYDHFVANCTLQFQELLRTTG PKCe_Hsap GQTATKQKTNSPAWHDEFVT-DVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNG- Pkc98E_Dmel DRATTRPKTFDPVWNEQFVH-DVTNVSNINLTVFHDAALPPDDFVANCIISFEDLMQSE- PKCh_Mmus GQTSTKQKTNKPTYNEEFCA-NVTDGGHLELAVFHETPLGYDHFVANCTLQFQELLRTAG PKCe_Mmus GQTATKQKTNSPAWHDEFVT-DVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNG- kin-13_Cele GKTQVRPKTNEPRWNEEFTASGVHQGKAIGFSVFHSCVMPPDDFVANTRIAFDQLKIGS- PKCe_Spur -------------------------------------A---------------------- AqueK018_Aque GKTTHKTNTYCPVWNELVEE-PVEDASRMQIALFHASTIPPNPFIAHVQVPVSEIRLTK- PKCh_Hsap ASDTFEGWVDLEPEGKVFVVITLTGSFTEATL--------QRDRIFKHF-----TRKRQR PKCe_Hsap -SRHFEDWIDLEPEGRVYVIIDLSGSSGEAPK-------DNEERVFRERMR---PRKRQG Pkc98E_Dmel -TAVQDLWVNLEPQGKIHVIIELKNRTDKAKAEAVVEHTVAVNKEFKERAG---FNRRRG PKCh_Mmus TSDTFEGWVDLEPEGKVFVVITLTGSFTEATL--------QRDRIFKHF-----TRKRQR PKCe_Mmus -SRHFEDWIDLEPEGKVYVIIDLSGSSGEAPK-------DNEERVFRERMR---PRKRQG kin-13_Cele -A--NDIWVDLEPHGQLHVVVEMHGTNVEDVH------SHNKTRVFKERTNAFNDRQRRG PKCe_Spur ----------------------------E----------PPKEKVFRVRENA--VHKRRG AqueK018_Aque -ED--EFTLELEPEGSIRFRIQFQEKWGSLAK--------K---EFHVRSQV--IKGHRG . *: . :: PKCh_Hsap AMRRRVHQINGHKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVT PKCe_Hsap AVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIIT Pkc98E_Dmel AMRRRVHQVNGHKFMATFLRQPTFCSHCREFIWGI-GKQGYQCQVCTLVVHKKCHLSVVS PKCh_Mmus AMRRRVHQVNGHKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVT PKCe_Mmus AVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIIT kin-13_Cele AMRRKIHEVTGHKFMALFLRQPTFCAHCKEFIWGI-GKQGYQCQICTVVVHKRCHEDVVW PKCe_Spur AVRRRVHQVNGHKFMSTFLRQPTFCSHCQDFIWGL-YRQGYQCQVCTVVVHKRCHEQIIT AqueK018_Aque AVRRKIHIVNAHKFMATYLRQFTFCAHCRDFIWGLVNKQGYQCQVCSMVVHKRCHKSIIT *:**::* :..****: :*** *:*:**::****: :******:*: ****:** :: PKCh_Hsap ACTCQNNIN--KV---DSKIAEQRFGINIPHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQ PKCe_Hsap KCAGLKKQE---T---PDQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQ Pkc98E_Dmel KCPGMRDEQPAKV---EMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQ PKCh_Mmus ACTCQNNIN--KV---DAKIAEQRFGINIPHKFNVHNYKVPTFCDHCGSLLWGIMRQGLQ PKCe_Mmus KCAGLKKQE---T---PDEVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQ kin-13_Cele KCPGNKADAVEELGKEIQETGAGRFNINMPHRFSVHSYKRPTFCDHCGSMLYGLINQGLQ PKCe_Spur RCPGHKDEGVN------DQVGSQRFNINIPHRFSLHNFRRPTFCDHCGSLLYGLFKQGVQ AqueK018_Aque PCTGRKITE--DE---DTAKASARFSINVPHRFKVHNYKRPTFCSHCGSLLWGLYRQGLK *. . . **.:*:**:* :*.:: ***.****:*:*: .**:: PKCh_Hsap CKICKMNVHIRCQANVAPNCGVNAVELAKTLAGMGLQPGNISPTSKLVSRSTLRRQ---- PKCe_Hsap CKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLIAGAESPQP Pkc98E_Dmel CETCGMNVHKRCQKNVANTCGINTKQMAEILSSLGISPDKQQPRRSKYLNQ-Q-GGE--D PKCh_Mmus CKICKMNVHIRCQANVAPNCGVNAVELAKTLAGMGLQPGNISPTSKLISRSTLRRQ---- PKCe_Mmus CKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLAAGAESPQP kin-13_Cele CSTCKLNVHKRCQRNVANNCGINAKQMAAELAQLGLTGDKMSIRSKKKPSIMTDTST--D PKCe_Spur CEVCKMNVHKRCSRNVANNCGVNNKEMADILREMGVTGDKLSIKRKKSSFEIR-KHH--P AqueK018_Aque CEACAINVHQRCEQFVAHSCGIDQVSLAKMMSQMGVSADQLSLSGSKRKSVTSVK-SEEN *. * :*** **. ** .**:: :* : :*: .: . PKCh_Hsap ------------------------------------------------------------ PKCe_Hsap ASGSS-PSEEDRSKSAPTSPCDQEIKELENNIRKALSFDNRG---------------E-E Pkc98E_Dmel NYGASLGADGDGAPGQSFRSCALSVDSLATSTTTMTS---------------GYNSSS-C PKCh_Mmus ------------------------------------------------------------ PKCe_Mmus ASGNS-PSEDDRSKSAPTSPCDQELKELENNIRKALSFDNRG---------------E-E kin-13_Cele ISGSS-NSENS-----------------------------------------G----Y-L PKCe_Spur PLNNS------RSLSLSSAPLLQELEGTS-NRHSAFACHQPYSMHHYQSTSKIEEMSECA AqueK018_Aque --GPL-KPPD-------------------------------------------------- PKCh_Hsap -----------GKE---SSKEGNG-IGVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVKE PKCe_Hsap HRA---ASSPDGQL---MSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKG Pkc98E_Dmel MSL---AVTGSGGV-----G---AT-GETRPGKCSLLDFNFIKVLGKGSFGKVMLAEKKG PKCh_Mmus -----------GKE---GSKEGNG-IGVNSSSRFGIDNFEFIRVLGKGSFGKVMLARIKE PKCe_Mmus HRA---SSATDGQL---ASPGENGEVRPGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKG kin-13_Cele QQI---SEDDSGTT---SSR---SA-SKVPGGTLSIHDFTFMKVLGKGSFGKVMLAERKG PKCe_Spur DKLTLGDSKGHGGSGMRTQSLQ-EELERKPSKRYNLDNFTFLKVLGKGSFGKVMLAERKG AqueK018_Aque ----------IPA----PVRQIKAPEPAALQKVVTLDDFKFLKVLGKGSFGKVLLAEMKN : :* *::**********:**. * PKCh_Hsap TGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFV PKCe_Hsap KDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYV Pkc98E_Dmel TDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYV PKCh_Mmus TGELYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFV PKCe_Mmus KDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYV kin-13_Cele TDEVYAIKILKKDVIVQDDDVECTMCEKRILSLAAKHPFLTALHSSFQTSDRLFFVMEYV PKCe_Spur TDEVYAIKVLKKHAIIQDDDVECTMTEKRVLVLANRHPFLTSLHSCFQTKDRLFFVMEYV AqueK018_Aque SDRVYAIKVLRKDV-IQDDDIECVLTEKRVLALACRHPYLTSMHSCFQTEERLFFVMEYV .. :**:*:*:*.. :****::*.: ***:* ** .**:** :...*** :*******:* PKCh_Hsap NGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLA PKCe_Hsap NGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLA Pkc98E_Dmel NGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLA PKCh_Mmus NGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHEKGIIYRDLKLDNVLLDHEGHCKLA PKCe_Mmus NGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLA kin-13_Cele NGGDLMFQIQRARKFDESRARFYAAEVTCALQFLHRNDVIYRDLKLDNILLDAEGHCRLA PKCe_Spur NGGDLMFQIQRARKFNEPRARFYAAEVTLALMFLHRHGVIYRDLKLDNILLDMDGHCKLA AqueK018_Aque NGGDLMFQIQRVRKFDEDRARFYSAEIILALLFLHNVGIIYRDLKLDNVLLDSDGHVKVA *******:**: *:*: *: **:**: ** *** .:*********:*** :** ::* PKCh_Hsap DFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEA PKCe_Hsap DFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEA Pkc98E_Dmel DFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFEA PKCh_Mmus DFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEA PKCe_Mmus DFGMCKEGIMNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEA kin-13_Cele DFGMCKEGINKDNLTSTFCGTPDYIAPEILQEMEYGVSVDWWALGVLMYEMMAGQPPFEA PKCe_Spur DFGMCKEGILDGRTTATFCGTPDYIAPEILQELDYGPSVDWWALGVLMYEMMAGQPPFEA AqueK018_Aque DFGMCKENIKDGRLTSTFCGTPDYIAPEILEEKDYGSSVDWWALGILMYEMMAGQPPFEA *******.* .. *:**************:* ** :*****:*:*:***:.*:.**** PKCh_Hsap ENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSL-TQGGEHAILRHPFFK PKCe_Hsap DNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFK Pkc98E_Dmel DNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGCT---GDENEIRKHPFFA PKCh_Mmus ENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSL-TQGGEHEILRHPFFK PKCe_Mmus DNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVAAQNGEDAIKQHPFFK kin-13_Cele DNEDDLFEAILNDDVLYPVWLSKEAVNILKAFMTKNAGKRLGCVVSQGGEDAIRAHPFFR PKCe_Spur DNEDDLFDSILHDDVLYPVWLSKEATSILKAFMTKNPSKRLGCMEAQGGERAILSHSFFR AqueK018_Aque DNEDELFEAIRNDEVLYPVWLSREANSILRGFLTKNPARRLGCQ-PGIGERQIKIHAFFR :***:**::* :*:*:**.** .:* .**:.*:***. ***. .* * *.** PKCh_Hsap EIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFS PKCe_Hsap EIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQINQEEFKGFS Pkc98E_Dmel KLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTPIGNEVVRCINQDEFAGFS PKCh_Mmus EIDWAQLNHRQLEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFS PKCe_Mmus EIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPILTLVDEAIIKQINQEEFKGFS kin-13_Cele EIDWDALESRQVKPPFKPKIKSKRDANNFDSDFTKEEPVLTPSDPAVVRAINQDEFRGFS PKCe_Spur EIHWQELEELKVEPPFKPKIKTKKDWNNFDTDFTREEPKLTPITTKIVESINQNEFSGFT AqueK018_Aque TIDWEKLEKRQIPPPFKPQVRGKRDFSNFDADFITEEPRLTPIESSALDNISQTEFKDFT :.* *: :: ***:*::: .* .*** :* *:* ** : *.* ** .*: PKCh_Hsap YVSPELQ---------P PKCe_Hsap YFGEDLM---------P Pkc98E_Dmel FVNPKFGP----ERKVY PKCh_Mmus YVSPELQ---------L PKCe_Mmus YFGEDLM---------P kin-13_Cele FINPHFT---------Y PKCe_Spur YTRPTEEETQATTTDID AqueK018_Aque YTNAEFV---------A :