CLUSTAL W (1.83) multiple sequence alignment PKCz_Hsap MPS----------RTGP------------KMEGSGGRVRLKAHYGGDIFITSVDAATTFE PKCi_Hsap MPT----------QRDS--STMSHTVAGGGSGDHSHQVRVKAYYRGDIMITHFEPSISFE aPKC_Dmel MPS----------QILNDGSSVSLNSASMNMANTPNSITVKTAYNGQIIITTINKNISYE PKCz_Mmus MPS----------RTDP------------KMDRSGGRVRLKAHYGGDILITSVDAMTTFK PKCi_Mmus MPT----------QRDS--STMSHTVACGGGGDHSHQVRVKAYYRGDIMITHFEPSISFE pkc-3_Cele MSS----------PTSL------------EE---DGDIKLKTRFQGQVVVLYARPPLILD PKCi_Spur MAL----------HR------------ALHIENV-------------------------- AqueK019_Aque ------------------------------------------------------------ AqueK020_Aque MHFGCGRFAAFPCSFLP--PFSAFLSRLSKMGDD--IIPVRLSFRGKDIKFSLVPNLAVT PKCz_Hsap ELCEE------VRDMCRLHQQ--HPLTLKWVDSEGDPCTVS--SQMELEEAFRLARQCRD PKCi_Hsap GLCNE------VRDMCSFDNE--QLFTMKWIDEEGDPCTVS--SQLELEEAFRLYELNKD aPKC_Dmel ELCYE------IRNICRFPLD--QPFTIKWVDEENDPCTIS--TKMELDEAIRLYEMNFD PKCz_Mmus DLCEE------VRDMCGLHQQ--HPLTLKWVDSEGDPCTVS--SQMELEEAFRLVCQGRD PKCi_Mmus GLCSE------VRDMCSFDNE--QPFTMKWIDEEGDPCTVS--SQLELEEAFRLYELNKD pkc-3_Cele DFFAL------LKDACKQHKK--QDITVKWIDEDGDPISID--SQMELDEAVRCLNSSQE PKCi_Spur AVCREREIEASMHCIARRHTTATTSCSRSWSRRTNIPACTS--RHQACFSCNRCSLS--S AqueK019_Aque ------------------------------------------------------------ AqueK020_Aque DVSNE------IRKQCGLHSA--APFNLKYLDVENDPVSVSLDRQREWDEAIRLFFYNEE PKCz_Hsap EGLIIHVFPSTPEQPGLPCPGEDKSIY-RRGARRWRKLYRANGHLFQAKRFNRRAYCGQC PKCi_Hsap SELLIHVFPCVPERPGMPCPGEDKSIY-RRGARRWRKLYCANGHTFQAKRFNRRAHCAIC aPKC_Dmel SQLVIHVFPNVPQAPGLSCDGEDRSIY-RRGARRWRKLYRVNGHIFQAKRFNRRAFCAYC PKCz_Mmus EVLIIHVFPSIPEQPGMPCPGEDKSIY-RRGARRWRKLYRANGHLFQAKRFNRGAYCGQC PKCi_Mmus SELLIHVFPCVPERPGMPCPGEDKSIY-RRGARRWRKLYCANGHTFQAKRFNRRAHCAIC pkc-3_Cele AELNIHVFVGKPELPGLPCQGEDKTVY-RRGARRWKKIYLYNGHRFQAKRLNRRIQCFIC PKCi_Spur STGKWRVFPTVPVRPGLPCPGEDRNIY-RRGARRWRKLYKVNGHTFQPKRFSRRALCTYC AqueK019_Aque ------------------------------------------------------------ AqueK020_Aque KELQLHVFEGPPPKPGELCEGEDTRVYHRRGARRWRKVRRINGHAFVAKRLQ-AAYCAKC PKCz_Hsap SERIWGLARQGYRCINCKLLVHKRCHGLVPLT--CRKHMDSVMPSQEPPVDDK------- PKCi_Hsap TDRIWGLGRQGYKCINCKLLVHKKCHKLVTIE--CGRHSLPQEP--VMPMDQS------- aPKC_Dmel QDRIWGLGRQGFKCIQCKLLVHKKCHKLVQKH--CTDQPEPL--VKE-RAEESSDPIPVP PKCz_Mmus SERIWGLSRQGYRCINCKLLVHKRCHVLVPLT--CRRHMDSVMPSQEPPVDDK------- PKCi_Mmus TDRIWGLGRQGYKCINCKLLVHKKCHKLVTIE--CGRHSLPPEP--MMPMDQT------- pkc-3_Cele HDYIWGIGRQGFRCVDCRLCVHKKCHRHVRTH--CGQALQGPNIIPMAPASGS---L--- PKCi_Spur ADRIWGLGRQGYKCVDCKLLVHKKCHRLVKVS--CAERQANLSTLDE-RSGSGSLP-HFG AqueK019_Aque ------------------------------------------------------------ AqueK020_Aque RERIWGLGRQGYKCEACKMVVHKRCCYYLNKDEICAGHPPA-----KQPEESD------- PKCz_Hsap ---NEDADLPSEE-TDG-IAYISSSRKHD--SIKDDSEDLKPVIDGMDGIKISQGLGLQD PKCi_Hsap -------SMHSDHAQTV-IPYNPS--SHE--SLDQVGE-EKEAMNTRESGKASSSLGLQD aPKC_Dmel LP-----PLPYEA-MSG-GAEACETHDHA--HIVAPPPP--ED--PLEPG-TQRQYSLND PKCz_Mmus ---NDGVDLPSEE-TDG-IAYISSSRKHD--NIKDDSEDLKPVIDGVDGIKISQGLGLQD PKCi_Mmus --------MHPDHTQTV-IPYNPS--SHE--SLDQVGE-EKEAMNTRESGKASSSLGLQD pkc-3_Cele --KGARSNTSSSTTRSGGGIDNGAFHEHEIESPGSTSHDASRAMNGNG--SSKWAVSLND PKCi_Spur SKPGDRSDSHHKR-SKS-GSPRHRRKNRD--STASSTPS--TAPNGNDKI-GNSPISLDD AqueK019_Aque ------------------------------------------------------------ AqueK020_Aque -------KKPSDPF--------------------------NDFLN-I-NPVSESQISLDD PKCz_Hsap FDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNP PKCi_Hsap FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHP aPKC_Dmel FELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHP PKCz_Mmus FDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNP PKCi_Mmus FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHP pkc-3_Cele FRLLTVIGRGSYAKVVQAEHVSTRQIYAIKIIKKEMFNEDEDIDWVQTEKSVFEAASNYP PKCi_Spur FELLRVIGRGSYAKVLLVELKATSRVYAMKVIKKELVTDDEDIDWVQTEKHVFETASNHP AqueK019_Aque ----------------MVELKQTKRIYAMKVIKKELVMDEEDIDWVQTEKHVFEQASNHP AqueK020_Aque FDILKVIGRGSYAKVLMVELKQTKRIYAMKVIKKELVMDEEDIDWVQTEKHVFEQASNHP .. . ::**:*::** :. ::********** *** **. * PKCz_Hsap FLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERG PKCi_Hsap FLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERG aPKC_Dmel FLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKG PKCz_Mmus FLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERG PKCi_Mmus FLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERG pkc-3_Cele FLVGLHSCFQTESRLFFVIEFVPGGDLMFHMQQQRKLPEEHARFYSGEIILALHFLHSRG PKCi_Spur FLVGLHSCFQTVSRLFFVIEFVSGGDLMFHMQRQRRLPEEHARFYSSEISLALNFLHEGG AqueK019_Aque FLVGLHSCFQTESRLFFVIECVNGGDLMFHMQRHRRLPEEHARFYSAEIALALNFLHEKG AqueK020_Aque FLVGLHSCFQTESRLFFVIECVNGGDLMFHMQRHRRLPEEHARFYSAEIALALNFLHEKG *********** ****:*** * *****:***::*:*********:.** :**::**. * PKCz_Hsap IIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFS PKCi_Hsap IIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFS aPKC_Dmel IIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFS PKCz_Mmus IIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFS PKCi_Mmus IIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFS pkc-3_Cele IIYRDLKLDNVLIDAEGHIKLTDYGMCKENIKDGDLTSTFCGTPNYIAPEILRGDEYGFS PKCi_Spur VIYRDLKLDNVLLDADGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYDFS AqueK019_Aque IIYRDLKLDNVLLDQDGHIKLTDYGMCKEGLRAGDTTSTFCGTPNYIAPEILRGQDY--- AqueK020_Aque IIYRDLKLDNVLLDQDGHIKLTDYGMCKEGLRAGDTTSTFCGTPNYIAPEILRGQDYGFS :***********:* :*************.: ** ******************::* PKCz_Hsap VDWWALGVLMFEMMAGRSPFDII--TDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVL PKCi_Hsap VDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVL aPKC_Dmel VDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVL PKCz_Mmus VDWWALGVLMFEMMAGRSPFDII--TDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVL PKCi_Mmus VDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVL pkc-3_Cele VDWWALGVLMFEMMAGRSPFDIVG-MQNSEENTEDYLFQIILERQIRIPRSLSVRASGIL PKCi_Spur VDWWALGVLMFEMLAGRSPFDIVGNADHPDQNTEDYLFQVILEKPIRIPRSLSVKAASVL AqueK019_Aque ------------------------------------------------------------ AqueK020_Aque VDWWALGVLLYEMLAGKSPFDVGG-HDMSDQSTEDYLFQVILEKTIRIPRTLSVKAAQVL PKCz_Hsap KGFLNKDPKERLGCRP--QTGFSDIKSHAFFRS-IDWDLLEKKQALPPFQPQITDDYGLD PKCi_Hsap KSFLNKDPKERLGCHP--QTGFADIQGHPFFRN-VDWDMMEQKQVVPPFKPNISGEFGLD aPKC_Dmel KGFLNKNPADRLGCHR--ESAFMDIVSHPFFKN-MDWELLERKQVTPPFKPRLDSDRDLA PKCz_Mmus KGFLNKDPKERLGCRP--QTGFSDIKSHAFFRS-IDWDLLEKKQTLPPFQPQITDDYGLD PKCi_Mmus KSFLNKDPKERLGCHP--QTGFADIQGHPFFRN-VDWDMMEQKQVVPPFKPNISGEFGLD pkc-3_Cele KGFLNKDPTERLGCKLDINEGLRDMKEHQFFRGFIDWEALEQKAVAPPYHPAVESDRDLT PKCi_Spur KGFLNKNPIERLGCHP--QTGFGDITGHPFFKT-IDWDRIESRQVTPPYKPHLQSDRDLE AqueK019_Aque ------------------------------------------------------------ AqueK020_Aque KGFLNKSPGERLGCHL--QTGFADITNHSFYKT-IDWELLRCRQITPPYKPRIDSDRDPS PKCz_Hsap NFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEES--------------- PKCi_Hsap NFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEEC--------------- aPKC_Dmel NFPPEFTGEAVQLTPDDDHVIDNIDQSEFEGFEYVNPLLMSLEDCLYGEDSSDYDSVADD PKCz_Mmus NFDTQFTSEPVQLTPDDEDVIKRIDQSEFEGFEYINPLLLSAEES--------------- PKCi_Mmus NFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEEC--------------- pkc-3_Cele HFDHQFTDELPQLSPDNPDVIARIDQSEFDGFEYVNPLQMSREDS--------------- PKCi_Spur HFDPQFTEEPIQLTPDDPGVLSQIDQGEFEGFEYINPLLMSGEEC--------------- AqueK019_Aque ------------------------------------------------------------ AqueK020_Aque NFDPQFVTEPIQFTPDDPETIGHIDQSEFAGFEYINPLLMSKIEE--------------- PKCz_Hsap ------------------------------------------------------------ PKCi_Hsap ------------------------------------------------------------ aPKC_Dmel LSLLHLNSAAGAGGSVSSNNNLSQQQHYRQQQQQQYQPHSAYSQQQQQQQQHQHAAATSA PKCz_Mmus ------------------------------------------------------------ PKCi_Mmus ------------------------------------------------------------ pkc-3_Cele ------------------------------------------------------------ PKCi_Spur ------------------------------------------------------------ AqueK019_Aque ------------------------------------------------------------ AqueK020_Aque ------------------------------------------------------------ PKCz_Hsap ------------V PKCi_Hsap ------------V aPKC_Dmel ASTSAATAATTSS PKCz_Mmus ------------V PKCi_Mmus ------------V pkc-3_Cele ------------V PKCi_Spur ------------V AqueK019_Aque ------------- AqueK020_Aque ------------V