CLUSTAL W (1.83) multiple sequence alignment p70S6Kb_Hsap -----------------------MAAVFDLDLETEEG--SEG----------------E- p70S6K_Hsap MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSED----------------E- p70S6Kb_Mmus -----------------------MAAVFDLDLETEEG--SEG----------------E- p70S6K_Mmus MRRRRRRDGFYLAPDFRHREAEDMAGVFDIDLDQPEDAGSED----------------E- R04A9.5_Cele MKQ--------------------------------------------------------- S6kII_Dmel MADV-----------------SDPSELFDLELHDLE--LQDDKARDSDD----------- YBR028C_Scer MI-------------------------FSLDEELHRVSLDDKKNDIKVDYSSAIYNDIN- p70RSK_Spur MAG--------------------HAGVFDLELCEHDEKANEC------------------ Y47D3A.16_Cele MA-----------------------DVFEFELEGHESQASPQRHAYHYD---------NC AqueK024_Aque MSDPD------------------LA--DGLELDQEE-IGSDD----------------E- p70S6Kb_Hsap --GEPELSP--ADAC-P--L--AELR-AAGLE--P------------------------- p70S6K_Hsap --LEEGGQL--NES-----M--DHGG-VGPYE-LG------------------------- p70S6Kb_Mmus --GEPEFSP--ADVC-P--L--GELR-AAGLE--T------------------------- p70S6K_Mmus --LEEGGQL--NES-----M--DHGG-VGPYE-LG------------------------- R04A9.5_Cele ------------------------------------------------------------ S6kII_Dmel ----DRIEL--DD----VDL--EPE-LCINLH-QD------------------------- YBR028C_Scer --HEQGSSITYEESINHLSVHSNAI-PLNGMSPAHRMRRRSSAYSKFPILTPPNTRRFSI p70RSK_Spur --LSDSDDM--QDEGAEG----DSY-LADGA--YE------------------------- Y47D3A.16_Cele TEIMEDDHM--YSNVADGQI--SAPPPSSSY--ME------------------------- AqueK024_Aque --VEEMMDG--TLIEDNSGL--VSGG-V-NID-ST------------------------- p70S6Kb_Hsap -----V-GHYEEVE-----LTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQ-G p70S6K_Hsap -----M-EHCEKFE-----ISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVT-G p70S6Kb_Mmus -----V-GHYEEVE-----LTESSVNLGPERIGPHCFELLSVLGKGGYGKVFQVRKVQ-G p70S6K_Mmus -----M-EHCEKFE-----ISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVT-G R04A9.5_Cele ------------VS-----MQKFEKLFYPDDVAPKDFERLKLVGEGGYGKVFQVRKQT-G S6kII_Dmel -----T-EGQETIQ-----LCEENVNPGKIKLGPKDFELKKVLGKGGYGKVFQVRKTA-G YBR028C_Scer TGSDAMRTNTNRLSITPQDIISSNIGENELSRNLHDFKPVRVLGQGAYGKVLLVKDV--- p70RSK_Spur -----S-IEVEEVS-----LSEETVNPGTEKVGPTDFQLLKVLGKGGYGKVFQVRKTT-G Y47D3A.16_Cele -----D-PMMESIQ-----LCASAINPPNVRVGPEDFQLLKVLGKGGYGKVFQVRKTT-G AqueK024_Aque -----A-GCLETLD-----ITPESINNTPEKIGPDCFELLKVLGKGGYGKVFQVRKRTGG .. : *: ::*:*.****: *:. p70S6Kb_Hsap TNLGKIYAMKVLRKAKIVRNAKDT-------------------------AHTRAERNILE p70S6K_Hsap ANTGKIFAMKVLKKAMIVRNAKDT-------------------------AHTKAERNILE p70S6Kb_Mmus TNLGKIYAMKVLRKAKIVCSAKDT-------------------------AHTRAERNILE p70S6K_Mmus ANTGKIFAMKVLKKAMIVRNAKDT-------------------------AHTKAERNILE R04A9.5_Cele EDKGTIYAMKVITKRKVTGTEKDL-------------------------RHARDERKILE S6kII_Dmel RDANKYFAMKVLKKASIVTNQKDT-------------------------AHTRAERNILE YBR028C_Scer -NTSKLYAMKQLRKAEILISQTATDSKREDEDKNDGNNNDNDDGLSKRLERTFAERSILS p70RSK_Spur KDSGKIFAMKVLKKAKIVRNQKDT-------------------------AHTKAERNILE Y47D3A.16_Cele SDNGQIFAMKVLQKATIVRNQKDT-------------------------AHTKAERNILE AqueK024_Aque KDKGRIFAMKVLKKASIVRSKKDT-------------------------MHTRSERNILE : . :*** : * : . . :: **.**. p70S6Kb_Hsap SVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGH p70S6K_Hsap EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGH p70S6Kb_Mmus SVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGH p70S6K_Mmus EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGH R04A9.5_Cele TINSPFLCDLHYAFQTNEKLYLVLEFLHGGELYTLLERKSDWPEEYARFYLSEIILAIEH S6kII_Dmel AVKHPFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGH YBR028C_Scer EIEHPNIVKLFYSFHDNSKLYLLLQYIPGGELFYHLKEHGTLDETTVSFYAAEISCALRF p70RSK_Spur AVQHPFIVDLHYAFQTGGKLYLILAYLGGGELFMHLEREGIFMEDTACFYLSEIVLALEH Y47D3A.16_Cele AVKSPFICDLLYAFQTGGKLYLILEYLSGGELFMHLEREGMFMENVAKFYLSEIVVSLEH AqueK024_Aque AIQHPFIVSLLYAFQTNGKLYLILDYLSGGELFALLEREGVFLEDTASFYLAEITLAIGH :: * : .* *:*: . ****:* : ****: *:... * . ** :** :: . p70S6Kb_Hsap LHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAV----------THTFCGTIE p70S6K_Hsap LHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTV----------THTFCGTIE p70S6Kb_Mmus LHSHGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAI----------THTFCGTIE p70S6K_Mmus LHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTV----------THTFCGTIE R04A9.5_Cele LHGHDIVYRDLKPDNVMLNLAGHVVLTDFGLCKYKLKKGEK----------TLTFCGTHE S6kII_Dmel LHKLGIIYRDLKPENILLDAQGHVKLTDFGLCKEHIQEGIV----------THTFCGTIE YBR028C_Scer LHTKGVVYRDLKPENCLLNQRGHLVLTDFGLSKKSANDSAVDEEDPENVNALYSIIGTPE p70RSK_Spur LHKLGIIYRDLKPENIMLNKQGHVVLTDFGLCKESLEEGSM----------THTFCGTIE Y47D3A.16_Cele LHQQGIIYRDLKPENILLDAYGHVKLTDFGLCKEEIEGDQK----------THTFCGTIE AqueK024_Aque LHSNGIIYRDLKPENIMLNGKGHVVLTDFGLSKESLHGEAT----------TNTFCGTIE ** .::******:* :*. **: ******.* . :: ** * p70S6Kb_Hsap YMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKL--ALPPYL p70S6K_Hsap YMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKL--NLPPYL p70S6Kb_Mmus YMAPEILVRTGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIKGKL--VLPPYL p70S6K_Mmus YMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKL--NLPPYL R04A9.5_Cele YMAPEMIRKVGHDHAVDVWALGILMYDMFMGGPPFTGETPADKDKSILKGKV--RLPPKL S6kII_Dmel YMAPEILTRSGHGKAVDWWSLGALMFDMLTGVPPFTAENRKKTIETILKAKL--NLPAYL YBR028C_Scer YCAPEILLGKAYSQNCDWYSLGCLLYDMLVGKPPYTGSNHKVIINKIQQNKQGPKIPFYL p70RSK_Spur YMAPEIVSRSGHGKDVDWWSLGALMYDMLTGGPPFTAENRKKTIEKILKGKL--SLPPYL Y47D3A.16_Cele YMAPEILMRCGHGKAVDWWSLGALMFDMLTGGPPFTAENRRKTIDKILKGRL--TLPAYL AqueK024_Aque YMAPEILQRIGHGKAVDWWSLGTLMYDMLTGAPPFCADNRKKTIDRILHGRL--YLPPYL * ***:: .:.: * ::** *::**: * **: ... . * : : :* * p70S6Kb_Hsap TPDARDLVKKFLKRNPSQRIG---------------------GGPGDAADVQRHPFFRHM p70S6K_Hsap TQEARDLLKKLLKRNAASRLG---------------------AGPGDAGEVQAHPFFRHI p70S6Kb_Mmus TPDARDLAKKFLKRNPTQRIG---------------------GGLGDAADVQRHPFFRHI p70S6K_Mmus TQEARDLLKKLLKRNAASRLG---------------------AGPGDAGEVQAHPFFRHI R04A9.5_Cele SASGKDLIKRIIKRDPTLRIT--------------------------IPDIKEHEFFEEI S6kII_Dmel TPEARDLVRRLMKRQEPQRLG---------------------SGPEDAAAVQIHPFFKHV YBR028C_Scer SEGMKDILNALLKKETAKRWNVDKYWAKTGANNKPTKSKKKKSGAARTSLFTEHFIFRKI p70RSK_Spur THEARDLVRKLLKRHISARLG---------------------SGPEDATRIRKHPFFRHV Y47D3A.16_Cele SNEARDLIKKLLKRHVDTRLG---------------------AGLSDAEEIKSHAFFKTT AqueK024_Aque TADAKDIIKKLLKRHPPNRLG---------------------SGPEDNKPIKEHRFFKMI : :*: . ::*:. * . * :*. p70S6Kb_Hsap NWDDLLAWRV----DPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDT------ALSES-A p70S6K_Hsap NWEELLARKV----EPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDS------TLSES-A p70S6Kb_Mmus NWDDLLARRV----DPPFRPSLQSEEDVSQFDARFTRQTPVDSPDDT------ALSES-A p70S6K_Mmus NWEELLARKV----EPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDS------TLSES-A R04A9.5_Cele DWDKLMAHDF----EPPFKPTLANLEDVSHFDESFTSIAPEESPCKA------ITTYTHV S6kII_Dmel NWDDVLARRL----EPPIKPLLRSEDDVSQFDTRFTRQIPVDSPDDT------TLSES-A YBR028C_Scer DWKLLESGQLQKTTLGPIVPVITDLELAENFDTEFTSMSYEETYTDSKPININSVSK-SP p70RSK_Spur KWDDVLARKG----EPPITPAVVNEEDVSQFDSKFTKQTPVDSPDDS------MLSES-A Y47D3A.16_Cele DWNLVYARQL----EAPFKPNIENDEDTSLFDARFTKMTPVDSPCET------NFSLN-G AqueK024_Aque NWEDLFNQKV----EPPFKIPVRGDDDVSQFDTKFTTLLPVDSPVDT------TISAS-A .*. : *: : . : .. ** ** :: .: : p70S6Kb_Hsap NQAFLGFTYVAP-SVL-------------------------------------------- p70S6K_Hsap NQVFLGFTYVAP-SVL-------------------------------------------- p70S6Kb_Mmus NQAFLGFTYVAP-SVL-------------------------------------------- p70S6K_Mmus NQVFLGFTYVAP-SVL-------------------------------------------- R04A9.5_Cele LELFLLFFSMSP-EENGRILNKNKNQSKVMPNLNVKSDMVLTEEEIKKYNGKVLALHRLL S6kII_Dmel NLIFQGFTYVAP-SIL-------------------------------------------- YBR028C_Scer -DMFKGFSYKASGSYL-------------------------------------------- p70RSK_Spur NQIFLGFTYVAP-SVL-------------------------------------------- Y47D3A.16_Cele DNPFVGFTYVAP-SVL-------------------------------------------- AqueK024_Aque DMNFKGFTYIAD-SFL-------------------------------------------- * * : . p70S6Kb_Hsap -----------------DSIKEGFSFQPK-----------------------LRSP---- p70S6K_Hsap -----------------ESVKEKFSFEPK-----------------------IRSP---- p70S6Kb_Mmus -----------------DSIKEGFSFQPK-----------------------LRSP---- p70S6K_Mmus -----------------ESVKEKFSFEPK-----------------------IRSP---- R04A9.5_Cele SNKVKKYRKLDENVDYIEFVQKGFMYLLSIGRQEYNKNAMNRSNEFEWKIPKLEEPENIQ S6kII_Dmel -----------------EDMHRANRM--P-----------------------ARSP---- YBR028C_Scer -----------------E------------------------------------------ p70RSK_Spur -----------------ESMHQKVHHFTK-----------------------VRSP---- Y47D3A.16_Cele -----------------EMMNKGGHGGIS----------------VA---HLASSM---- AqueK024_Aque -----------------EDVYSHSVSSPS-----------------------SYR----- : p70S6Kb_Hsap ------------------------------RRLN--SSPRAPVSPLKFSPF-----E--G p70S6K_Hsap ------------------------------RRFI--GSPRTPVSPVKFSPG-----DFWG p70S6Kb_Mmus ------------------------------RRLN--SSPRTPISPLKFSPF-----E--G p70S6K_Mmus ------------------------------RRFI--GSPRTPVSPVKFSPG-----DFWG R04A9.5_Cele DVNLFEETEPEKFTKGYIKEELPDKICSTVRKV--IKIPRSALEKVGVRLHD-----DEQ S6kII_Dmel ------------------------------RRTPR-QLPDSSFR-LQFPSA-----NV-- YBR028C_Scer ------------------------------------------------------------ p70RSK_Spur ------------------------------RKIPGSISPRSAISPAKTPQT-----QFA- Y47D3A.16_Cele ------------------------------SRAGAAKSPRKPGDPETASILHGGHSNLFG AqueK024_Aque ------------------------------NRP--LRSPHKHLSPVTTETN-----QVFG p70S6Kb_Hsap FRPSP-------SL---------------------------------------------- p70S6K_Hsap RGASA-------ST---------------------------------------------- p70S6Kb_Mmus FRPSP-------GP---------------------------------------------- p70S6K_Mmus RGASA-------ST---------------------------------------------- R04A9.5_Cele -KPTHLLSDDIKTEPIEEATHVNVIQTPSWKPKFQCISDLLKDDTTDFDCEMSLGSSVLF S6kII_Dmel -GAN---------APLA------------------------------------------- YBR028C_Scer ------------------------------------------------------------ p70RSK_Spur -------------------FDEDLLTKPS----------------------------SSR Y47D3A.16_Cele HGPNS-------EAPQA--FGYGIGSQMT----------------------------TTT AqueK024_Aque FNAPS---------PLT----------------------------------------VSS p70S6Kb_Hsap ------PEPTE------LPLPPLLP----------------------------------- p70S6K_Hsap ------ANPQT------PVEYPMETSGIEQM----------------------------- p70S6Kb_Mmus ------PEPME------PSLPPLLPS---------------------------------- p70S6K_Mmus ------ANPQT------PVEYPMETSGIEQM----------------------------- R04A9.5_Cele DRPDS-SLPIKKICPGF-----------PKK----ATEVGGRAEGAVHGWFSYKSYHLIY S6kII_Dmel ------MHGHS------Q------RSGMFAR----------------------------- YBR028C_Scer ------------------------------------------------------------ p70RSK_Spur AAPSS-ARPIQ------PIEEAMDTS-----------DG--ASN---------------- Y47D3A.16_Cele AGGAGIQQPYQSFSGGYPEDDAMDTSTPRASESRETTTGNGSTT---------------- AqueK024_Aque TAASSLLYTQ---------S-----------TIMEETSG--NST---------------- p70S6Kb_Hsap ------------------------------------------------------------ p70S6K_Hsap -----------------------------------DV----------------------- p70S6Kb_Mmus -----------------------------------PP----------------------- p70S6K_Mmus -----------------------------------DV----------------------- R04A9.5_Cele TKLIMIMGSIPSNKRIMSESQVRRELNASFARNCHPTAIGMQKLSERCGIRYKTIFDNFE S6kII_Dmel --------------------------------A--TP----------------------- YBR028C_Scer ------------------------------------------------------------ p70RSK_Spur --------------------------------AT-------------------------- Y47D3A.16_Cele --------------------------------TTRPS----------------------- AqueK024_Aque --------------------------------MIKAP----------------------- p70S6Kb_Hsap ------------------------------------------------------------ p70S6K_Hsap ------------------------------------------------------------ p70S6Kb_Mmus ------------------------------------------------------------ p70S6K_Mmus ------------------------------------------------------------ R04A9.5_Cele TIRKDGKIECETNDACCRIREFLSRETDTTSYIEITNEVQTVLEDEIELHLLSRKRFTLG S6kII_Dmel ------------------------------------------------------------ YBR028C_Scer ------------------------------------------------------------ p70RSK_Spur ------------------------------------------------------------ Y47D3A.16_Cele ------------------------------------------------------------ AqueK024_Aque ------------------------------------------------------------ p70S6Kb_Hsap ----PPPPSTTAPLPI--RP---PS-G-------------------------------TK p70S6K_Hsap ----TMSGEASAPLPI--RQ---PNSG-------------------------------PY p70S6Kb_Mmus ----SPPPTSTAPLPI--RP---PS-G-------------------------------TK p70S6K_Mmus ----TVSGEASAPLPI--RQ---PNSG-------------------------------PY R04A9.5_Cele YVHVIMEKTDLAPSYI--RA---QYENWRRKLSTKDRGSWKIGDSEAGLNKYFAKNNKPG S6kII_Dmel ----PHHMQTFAPR--P------S-PA-------------------------------QD YBR028C_Scer ------------------------------------------------------------ p70RSK_Spur --------------------------------------------------------A--- Y47D3A.16_Cele ----NVGSSASTPIPLPKRVIKLPHTH---T-------------------------S-TQ AqueK024_Aque ----VVNGSDHSHIPLLK-GINSIRTN---E-V----------------------DK-GN p70S6Kb_Hsap K----------------------------------------------------------- p70S6K_Hsap K-KQ-------------------------------------AFPM--------------I p70S6Kb_Mmus K----------------------------------------------------------- p70S6K_Mmus K-KQ-------------------------------------AFPM--------------I R04A9.5_Cele V-RQREKIAKKLGLSERQVRNYFNKKRITERKLKVWKDAPKDFLTLSKQTVDEMMKIAEE S6kII_Dmel E----------------------------------------------------------- YBR028C_Scer ------------------------------------------------------------ p70RSK_Spur ------------------------------------------------------------ Y47D3A.16_Cele NAQY-------------------------------------SFML--------------L AqueK024_Aque LVSP-------------------------------------GFNLKLS----------PP p70S6Kb_Hsap SK---------------------------R-GRGRPGR p70S6K_Hsap SK---------------------------RPEHLRMNL p70S6Kb_Mmus SK---------------------------K-GRGRSGR p70S6K_Mmus SK---------------------------RPEHLRMNL R04A9.5_Cele RRKPNDEYIQIANRLGVSHITLCSFIDWQKSIYAGKAK S6kII_Dmel MM---------------------------D-VQGLPMV YBR028C_Scer -----------------------------------KYF p70RSK_Spur -------------------------------AKTSGYR Y47D3A.16_Cele LL---------------------------NVSLFFHFF AqueK024_Aque AN---------------------------RP-AHLGLS