CLUSTAL W (1.83) multiple sequence alignment 8635_Tthe MQGLAQTPFDLFEPQQRLFRLPQKKSGVLKQQIFKEFIEKAQIKIKILDEENDNEVLFYT PLK4_Hsap MAT--------------------------------------------------------- 5034_Tthe MFSQEE---------------------------AKEQ----------------------- 21183_Tthe MIQQKK---------------------------DQKP----------------------- SAK_Spur M----------------------------------------------------------- PLK4_Mmus MAA--------------------------------------------------------- SAK_Dmel MLSNR------------------------------------------------------- zyg-1_Cele MSGGK------------------------------------------------------- AqueK201_Aque ------------------------------------------------------------ 8635_Tthe PILFGYLSLIILKESSSTIILKHTLCYCNGKPYLIKDHQIRLLFTRCLNKINNIEKFSKY PLK4_Hsap ------------------------------------------------------------ 5034_Tthe ------------------------------------------------------------ 21183_Tthe ------------------------------------------------------------ SAK_Spur ------------------------------------------------------------ PLK4_Mmus ------------------------------------------------------------ SAK_Dmel ------------------------------------------------------------ zyg-1_Cele ------------------------------------------------------------ AqueK201_Aque ------------------------------------------------------------ 8635_Tthe AMNPRNGEISLKDALFFEKETFQKFNESPLLAIKPMLELYNQQIHILKQYTKLILVVLEE PLK4_Hsap ------------------------------------------------------------ 5034_Tthe ------------------------------------------------------------ 21183_Tthe ------------------------------------------------------------ SAK_Spur ------------------------------------------------------------ PLK4_Mmus ------------------------------------------------------------ SAK_Dmel ------------------------------------------------------------ zyg-1_Cele ------------------------------------------------------------ AqueK201_Aque ------------------------------------------------------------ 8635_Tthe LPQIFNQYSDISFLSLNQINLQLLKVKMWLIDPDTFEDQSEINEQIKRQSQIVQKKDDLK PLK4_Hsap ------------------------------------------------------------ 5034_Tthe --------------------------------------------NSDEQNQEINEQERNS 21183_Tthe ----------------------------------------------KSSSQQVEE-EENH SAK_Spur ------------------------------------------------------------ PLK4_Mmus ------------------------------------------------------------ SAK_Dmel ------------------------------------------------------------ zyg-1_Cele ------------------------------------------------------------ AqueK201_Aque ------------------------------------------------------------ 8635_Tthe ILNEI-EIIGDIQNIEQINKGGFGSIQKGKLAKILKYPLYGHFSQTMSLITKLYIMWQIA PLK4_Hsap ---CIGEKIEDFKVGNLLGKGSFAGVYRAES----------------------------- 5034_Tthe LFNSLSAQLSDYIISHPIGSGAGSLVVKVKS----------------------------- 21183_Tthe LMNSISTSLHNFKITLTLGRGAGSCVFLIEE----------------------------- SAK_Spur -----EDRIENYQVLNLLGRGGFACVYRAKT----------------------------- PLK4_Mmus ---CIGERIEDFKVGNLLGKGSFAGVYRAES----------------------------- SAK_Dmel ---AFGETIEDYEVQHLLGKGGFATVYKARC----------------------------- zyg-1_Cele ----SGSRLSAYSHLKEIGKGGFGVVYAAQR----------------------------- AqueK201_Aque ----------DYEVLNRLGKGSFADVYRAKC----------------------------- :. *. . : . 8635_Tthe QGIQFLTSKNVAHLDLKPANIVISKGYLAKIIDFGEAYHPDVCNGKEFYNNQQRLIFKSY PLK4_Hsap ------------------------------------------------------------ 5034_Tthe ------------------------------------------------------------ 21183_Tthe ------------------------------------------------------------ SAK_Spur ------------------------------------------------------------ PLK4_Mmus ------------------------------------------------------------ SAK_Dmel ------------------------------------------------------------ zyg-1_Cele ------------------------------------------------------------ AqueK201_Aque ------------------------------------------------------------ 8635_Tthe FLMKGNPNYKPGRTLPYTPYSNNNDRQASYKNLDIFSFGMVLSEIVFDTYPVDFKRGALH PLK4_Hsap ------------------------------------------------------------ 5034_Tthe ------------------------------------------------------------ 21183_Tthe ------------------------------------------------------------ SAK_Spur ------------------------------------------------------------ PLK4_Mmus ------------------------------------------------------------ SAK_Dmel ------------------------------------------------------------ zyg-1_Cele ------------------------------------------------------------ AqueK201_Aque ------------------------------------------------------------ 8635_Tthe KLEEKFSRGDIRGRLVKNYQRHFGPKHIINLLHCLIFRCIDEKENRPTIDWIILISIYFK PLK4_Hsap ------------------------------------------------------------ 5034_Tthe ------------------------------------------------------------ 21183_Tthe ------------------------------------------------------------ SAK_Spur ------------------------------------------------------------ PLK4_Mmus ------------------------------------------------------------ SAK_Dmel ------------------------------------------------------------ zyg-1_Cele ------------------------------------------------------------ AqueK201_Aque ------------------------------------------------------------ 8635_Tthe EVNKFYQQQICKHKKTFKATKRVLTKKESTEIYFERQIKQFLYPLMIYTQVSDELSFKDI PLK4_Hsap ------------------------------------------------------------ 5034_Tthe ------------------------------------------------------------ 21183_Tthe ------------------------------------------------------------ SAK_Spur ------------------------------------------------------------ PLK4_Mmus ------------------------------------------------------------ SAK_Dmel ------------------------------------------------------------ zyg-1_Cele ------------------------------------------------------------ AqueK201_Aque ------------------------------------------------------------ 8635_Tthe EASLDYDIKGANGFVCKIEDFKSKECYNSNEAKKYYVYLLLTYTKQKAMKVVDKKRKDIQ PLK4_Hsap ----------------------------------------IHTGLEVAIKMIDKKAMYKA 5034_Tthe ----------------------------------------IKTKKEYAIKVVDKQSQYYK 21183_Tthe ----------------------------------------YKSG---------------- SAK_Spur ----------------------------------------ISTGQEVAIKMIDKKLMQSS PLK4_Mmus ----------------------------------------IHTGLEVAIKMIDKKAMYKA SAK_Dmel ----------------------------------------LHTHQDVAIKMIDKKLIQGT zyg-1_Cele -----------------------------------------ENGEKVAIKRIDKKVP--- AqueK201_Aque ----------------------------------------KRTKKEVAIKMIDKKLMVKK 8635_Tthe NVMKRLDQEIKIQKELDH-PNIIKLFKHFEDDQNHYLIMELAQNGEIKDYLNI------- PLK4_Hsap GMVQRVQNEVKIHCQLKH-PSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNR------ 5034_Tthe SAYKRLKNEIEIHLDLKH-KNIVKMIKSFEDSENLYLVMEYCEGGDLFHYLKH------- 21183_Tthe --------SLYLHSQLDH-PNIVKILKRFEDNEYVYMMLEYCPGGSLFDYIVYINFQLFE SAK_Spur GMATRVKNEVEIHCQLKH-PSILELYSYFEDNNYVYLVLELAQNGELLRYLKKK------ PLK4_Mmus GMVQRVQNEVKIHCQLKH-PSVLELYNYFEDNNYVYLVLEMCHNGEMNRYLKNR------ SAK_Dmel GLTNRVRQEVEIHSRLKH-PSVLQLYTFFQDANYVYLVLELAHNGELHRYMNHI------ zyg-1_Cele --KNRVWTEIQTMKELKKSKYVVEFYEDFVEDGYTYIVMELCEGGSLQAYVREH------ AqueK201_Aque GMTERVKNEVKIHSHLKH-PSILELYDFFEDSNYVYLILEFCQNGELNRYLKHR------ .: *.: :::: * : *:::* . .*.: *: 8635_Tthe NKP----------YQLACGIKYLHDKDIVHRDLKLNNVLLS-----NGKIKIADFGLATK PLK4_Hsap VKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLT----RNMNIKIADFGLATQ 5034_Tthe HKKLSETEAKRITYKLAEGLKYLHDKSIIHRDLKLGNVLLS----SDHQVKICDFGLAVR 21183_Tthe KTRLNEDEARDISYQIVQGLEYLHKNKIIHRDLKPGNILLT----GNNSVKICDFGLAVR SAK_Spur ARVFGEEEARQFLEEIVIGLLYLHSHGILHRDLTLANILLT----RDMHCKIADFGLAAQ PLK4_Mmus MKPFSEREARHFMHQIITGMLYLHSHGILHRDLTLSNILLT----RNMNIKIADFGLATQ SAK_Dmel ARPFTETEAASILKQVVAGLLYLHSHNIMHRDISLSNLLLS----REMHVKIADFGLATQ zyg-1_Cele G-ALDDATAVHVLRQLISAVSFMHRVNVIHRDLSAGNVFIKDSKKKKMTVKLGDFGLATT AqueK201_Aque QKSLSEDE-RIILNQVVKGLIYLHSFNIVHRDLSLSNILLT----SSMDIKIADFGLSVT :: .: ::* ::***:. *:::. . *: ****:. 8635_Tthe VNDENPECNTMCGTANYLSP-----------------EILNSKGYGKKTDIWSFGCILYA PLK4_Hsap LKMPHEKHYTLCGTPNYISP-----------------EIATRSAHGLESDVWSLGCMFYT 5034_Tthe LNGNEQEKNTICGTPNYISP-----------------EILNKQPYGMKIDCWSFGCILYA 21183_Tthe VTNYESERDTFCGTPNYIAP-----------------E-----KYGIQSDCWSFGCILYT SAK_Spur LKLPEEQHYTMCGTPNYISP-----------------EIATRGPHGLQSDVWSLGCMLYT PLK4_Mmus LNMPHEKHYTLCGTPNYISP-----------------EIATRSAHGLESDIWSLGCMFYT SAK_Dmel LKRPDERHMTMCGTPNYISP-----------------EVVSRTSHGLPADVWSVGCMLYT zyg-1_Cele LGRG-ETTCTIVGTPGFIAP-----------------QVYDQ-EYTQSADVYSLGAVLYT AqueK201_Aque LDLPGDKHHTLCGTPNYIAPYVICCYEGCFLIFIFCREVAKREAHGLESDIWSLGCMVYT : *: **..:::* : : * :*.*.:.*: 8635_Tthe LCSGNLPFFSGNPSQTIQNIKEGK--WQLPQNISDNVKDLLSNTLNWDQNSRFSIEQVLS PLK4_Hsap LLIGRPPFDTDTVKNTLNKVVLAD--YEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLD 5034_Tthe LIVGHPPFQGQDIVQTLKKVTSQEQFFELPNNISDNLKDLLVNIINWNQDSRFTIDQILM 21183_Tthe IATGRPPFETVSIQQTLKMLQKKN-KVEYPSHLSKSLVDLIDHILDWNQDTRYNISQIKS SAK_Spur FLTGTPPFDTEAVKTTLNKVMLAE--YIIPTHISMEAKDLINKMLRKDPTERIGLSTVLD PLK4_Mmus LLIGRPPFDTDTVKNTLNKVVLAD--YEMPAFLSREAQDLIHQLLRRNPADRLSLSSVLD SAK_Dmel LLVGRPPFETDAVQSTLNKVVMSE--YIMPAHLSYEAQDLINKLLKKLPHERITLEAVLC zyg-1_Cele MLTARNPPPKGLP-P--------------TCGMSPNAARLVEQMMDTDAKKRIPLTQIVL AqueK201_Aque MLVGTPPFDTDDVQSTLDNVVNGD--FDIPQYITTNCTSLNL--HVYHPSKRLTLQQVLY : . * . :: . * * : : 8635_Tthe HKFYEKKHKQSIIIFN-----------------------------QGADAISNQ-----Q PLK4_Hsap HPFMSRNSSTKSKDLG-----------------------------TVEDSIDSG-----H 5034_Tthe HPFYEEMRQKSVKQRQ-----------------------------EEEESLSFF-----N 21183_Tthe HPFYNKSKQNTHENEY-----------------------------KLQNPMTFAPPQPFQ SAK_Spur HPFMDKTRFNGTKNRP-LS---------------------K---RPVESSLDSG-----L PLK4_Mmus HPFMSRNPSPKSKDVG-----------------------------TVEDSMDSG-----H SAK_Dmel HPFMLKCSNGGHSAPG--A---------------------L---NVFSQSMESG-----D zyg-1_Cele SEFMYENTNENAVIFS-------------------------------------------- AqueK201_Aque HSFTKGVQQENVLQKRTLSLTTPVIATYRGDCQFHGSRVLKNIQLEAPASVDSG-----N * 8635_Tthe NKLSTP-------------NKVLL-------------DWTSP-RFNAPIHLQQKSQSSQK PLK4_Hsap A-----------------------TISTAIT-----------AS--SS------------ 5034_Tthe SIRSVKGEDQRINVHQNGVKKIDIKYQDNFFNQLEHKEGSMPKKSNSPTNIHERKNQMIY 21183_Tthe MEQSV-------NQNNKNIQQGHTRQRSNFS-----------MD--SS------------ SAK_Spur A-----------------------TMATISS-----------SH--TS------------ PLK4_Mmus A-----------------------TLSTTIT-----------AS--SG------------ SAK_Dmel S-----------------------GIITFAS-----------SD--SR------------ zyg-1_Cele ------------------------------R-----------EH--SR------------ AqueK201_Aque V-----------------------TLATNYS-----------GP--TS------------ : 8635_Tthe KNKRISNLKNQKS----LTSMKLDLSDCNKENQPNLINSSNNKSNNTAIIEKQKSTKSNT PLK4_Hsap ------------------TSISG------------------------------------- 5034_Tthe KNDQIAALKNNKIQNEDL-------------NIMS--NNLNQIQYKKQSQNN--LVKQND 21183_Tthe --NNSKHFQQNKIMNDNL-------------YQINNINRSNQIQENNVLQNK--QTKENR SAK_Spur ------------------NRTSS------------------------------------- PLK4_Mmus ------------------TSLSG------------------------------------- SAK_Dmel ------------------NSQQI------------------------------------- zyg-1_Cele ------------------DG---------------------------------------- AqueK201_Aque ------------------R-YST------------------------------------- 8635_Tthe YKEQQ--NIQSNQQNSLGMSNIFLTTARSINLADNSIIMSTLQDNQLNNTNNK-KENTKP PLK4_Hsap ----------------------------------------------SLFDKRR-LLIGQP 5034_Tthe KQILNQKEINFARKNS------------------PVDRFDVENQQNNMNKQKDDASHTVK 21183_Tthe FQSKEQLLVNENKENI------------------HSNILNSINNQQKLFQQQQ-KLNPIP SAK_Spur --------------------------------------------------RSR-PMRALP PLK4_Mmus ----------------------------------------------SLLD-RR-LLVGQP SAK_Dmel ----------------------------------------------RSVENSG-PQQVL- zyg-1_Cele ------------------------------------------------------------ AqueK201_Aque --------------------------------------------------RRG------- 8635_Tthe TQKLQYYLQQNSNTSQQLKQSS-------------------------------------- PLK4_Hsap LPNKMTVFPKNKSSTDFSSS-GDGNSFYTQWGN--------------------------- 5034_Tthe VKEIHSHNQQLNIRKQSPTNQILNYDK------DKIAIPERKSLTQQSQAINQNDVFKSP 21183_Tthe LQKSYSYNQKNEQKQDQILHQTLAQGLKKEVSEQSIDNNRNKQIIQEIQNISQNSYY--- SAK_Spur LSTLTPVISEGEGSRGQVKGHHHGDGIGSSWNQ--------------------------- PLK4_Mmus LPNKITVFQKNKNSSDFS-S-GDGSNFCTQWGN--------------------------- SAK_Dmel ------------------------------------------------------------ zyg-1_Cele ------------------------------------------------------------ AqueK201_Aque -PVKATFFPSS------------------------------------------------- 8635_Tthe ------------------------------------------------------------ PLK4_Hsap --------------------------QETSNSGRGRVIQDA-------------EERP-- 5034_Tthe KLTSNQQEIKQTFINNIEKIKSNQPPVPQNQQQQNNSAITT-------------YGGQ-- 21183_Tthe -----------------------NPQISQSNKQQQQQIDTI-------------QQKP-- SAK_Spur --------------------YD-R--HPPSPPVRQRANHSAALQSRSEQAGETLESRPWF PLK4_Mmus --------------------PE----QEANSRGRGRVIEDA-------------EERP-- SAK_Dmel --------------------------------------PQI-------------REEF-- zyg-1_Cele ------------------------------------------------------------ AqueK201_Aque --------------------------------G-SHLQEDQS------------RKAT-- 8635_Tthe -------------------------------------------ILNNQGQASGYNNSRNR PLK4_Hsap ---------HSRYLRRAYSSDRSGT-------------------SNSQSQAKTYTME--- 5034_Tthe ---------EKRGVKSIVY-NNSNNQNNINTNQNSNQYNIQNSITNNQINPTNNYKTVNS 21183_Tthe ---------QSKTILNTFL-NKATKSNSLHQS--------------SSTTPSSNQQNINT SAK_Spur SGAALKQKASSSQDLRMTSSDRMQPH-----------------VSSHTSQTRDYNLT-AK PLK4_Mmus ---------HSRYLRRAHSSDRASP-------------------SN-QSRAKTYSVE--- SAK_Dmel ---------KQVHHKLPY------------------------------------------ zyg-1_Cele --------------RRQRSREPVRS-------------------SR-DDRSRDG------ AqueK201_Aque ---------SGLHHRRAHSLE--------------------------------------- 8635_Tthe FDLSCNNVINQNKSQQSLLQYNGYKSQSVIPQQQQAFSQNSQQISNKNQPQQQNTKELT- PLK4_Hsap -----------------------RCHSAEML----------SVSKRSG-----GGENEER 5034_Tthe SNINNNYYSNTSQSQQF---INGINHQHDIHSRTAANSNHDKYIKNTN-----NIRNNS- 21183_Tthe NNFFQSQKSYKNPIVQI---LNGF------------------------------------ SAK_Spur PSINDGSMKGFD-TKTR---GMYQSHEQDIHRSQGHVYHDDAQVKRSG-----SWKSQEF PLK4_Mmus -----------------------RCHSVEML----------SKPRRS------------- SAK_Dmel -------------------------------EQTG-LFGQA------------------- zyg-1_Cele ----------------R---ALIRSSSQPAH----------------------------- AqueK201_Aque ------------------------------------------------------------ 8635_Tthe --PKQFNPYL---SQN-------------------------------------------- PLK4_Hsap YSPTDNNANIFNFFKEKT-SSSSGSFER---PDN----NQALSNHLCPGKT---PF---P 5034_Tthe --PVNNNSYI---ERNQSPNTQNNHMSSSSVLNNGQQQSQHKNNSYSISQSKVIPL---- 21183_Tthe ----PNDSKI---QQNQAINHQKNK---------------------SLDISGIIP----- SAK_Spur ---LGQHGSV---LREKSRTETSGHYDR---VDD----AK-------------------- PLK4_Mmus -------------------------------LDE----NQHSSNHHCLGKT---PF---P SAK_Dmel -------ST-------------------------------GLAE---------------- zyg-1_Cele -----------------------------------------------SGRA---PLSNRP AqueK201_Aque ------------------------------------------------------------ 8635_Tthe -------SEKTQQDYSN--NAFKSYRSTSSLHQNISIANT-SQTYRNPLQESQINKNNQQ PLK4_Hsap FADPTPQTETVQQWFGN--LQINAHLRKTTEYDSISPNRD-FQGHPDLQKDTSKNAWTDT 5034_Tthe -------PKKVQTSFLQNLNSLTDVDRFSPPHNNTNSTNTTTNNYVN-IQ-SEINNFPQP 21183_Tthe ---------------------------------------------------------PQP SAK_Spur -------------------------HRLFSEADIDSDRR---QDLT-VRTDHAKDKCTDK PLK4_Mmus FADQTPQMEMVQQWFGN--LQMNAHLGETNEHHTVSPNRD-FQDYPDLQ-DTLRNAWTDT SAK_Dmel -----------PNWPGA--AKSS------------------------------------- zyg-1_Cele IHDRMPS----------------------------------------------------- AqueK201_Aque ------------------------------------------------------------ 8635_Tthe RQEAFDNTKQALHNVK-------K--PLQYFSQQQ----QTQKD--GDNQMFTQSQNN-- PLK4_Hsap KVKKNSDASDNAHSVK-------QQNTMKYMTALH----SK--PEIIQQEC------VFG 5034_Tthe QTVSHNRTKNQVSFEN-------K--PIQAQVQNQ----TTQKVMQSSDQGFYKKNNNPP 21183_Tthe PR-PRDEQKNQLSFKTIDQENIQK--KQISIDQSNQNEFVTTPS--GNNKMFSQSSNN-- SAK_Spur KQSAQSSVSDHP-SVH-------GMHAAVPSSASC-----G--GLSSKQDGALHKDSKAG PLK4_Mmus RASKNADTSANVHAVK-------QLSAMKYMSAHH----HK--PEVMPQE--------PG SAK_Dmel ---------------------------------------------------AFCME--AG zyg-1_Cele -------------------------------TSSR--------GFDSERGRERDRDSGRG AqueK201_Aque ------------------------------------------------------------ 8635_Tthe ----------NTNKQMKGDNTLNG------------------------NLKYSSL-STNS PLK4_Hsap SDPLSEQSKTRGMEPP-------W--------------------------------GYQN 5034_Tthe QSVQTNLQRNQSPQLHVGNKNTSD------------------------NLNYYLTKKDHP 21183_Tthe ----------MIFMKENNNSKIQN------------------------VKKKMSL----- SAK_Spur ERSSHRRSKSKSHDLD-------KGSEWTHRHTRKHEKREGGGGGGKGEG------GAGV PLK4_Mmus LHPHSEQSKNRSMEST-------L--------------------------------GYQK SAK_Dmel NVPNSKQASLK------------------------------------------------- zyg-1_Cele TVPPSREDRN-------------------------------------------------- AqueK201_Aque ------------------------------------------------------------ 8635_Tthe QTLN--------------------------KNDESYIHNYHQ------------------ PLK4_Hsap RTLRSITSPLVAHRLKPIRQKTKKAVVSILDSEEVCVELVKE-----YASQ----EYVKE 5034_Tthe QCVE--------------------------DQADKYEEIIHQ-----RKNENKIINRENN 21183_Tthe ------------------------------------------------------------ SAK_Spur QSLAHLTPPLNATRLRPIRQRTRNAVVSIMLGGEVCLEFLKT-----KDGQ----DRVVE PLK4_Mmus PTLRSITSPLIAHRLKPIRQKTKKAVVSILDSEEVCVELLRE-----CASE----GYVKE SAK_Dmel -EDRISVPPLNTKRLLPTRYKTKNAIMSILRNGEVVLEFLKF---RPTYNE----DRIND zyg-1_Cele ---RSQLWPIRMDRLEGQRVCT--------AGGRYIVELDTRCRFEVAAQG----NFVKR AqueK201_Aque -----------------------------------------------------------D 8635_Tthe -PRIRSQQSQQNVNLREK---S-PSCQF-IQKNQEISSQNNCDGIKDLQNINKI-----Q PLK4_Hsap VLQISSDGN--TITIYYP---N-GGRGF-PLADR-PPSPT-------------------- 5034_Tthe IKRISSEQNISRVSTEYK---N-GSNDF-NTQNK-LNNQYNNNKINIDYTSNQLM--NNN 21183_Tthe -----------HFPTEQT---N-ISQDIISTNTT-CRNNITTTMTFPSPSSQQFLAQNNN SAK_Spur VLRISQDGM--QVTIYQP---N-GGKGF-PIMEH-PPSPP-------------------- PLK4_Mmus VLQISSDGT--MITVYYP---N-DGRGF-PLADR-PPLPT-------------------- SAK_Dmel ICRISDDGQ--RIIIYQP---D-PGRGL-PVREQ-PPDLQ-------------------- zyg-1_Cele ILIVEVDEM--VQTVYVHRIPDRTVRGR-NGEEE-LITLT-------------------- AqueK201_Aque VCRGNDEIM--------------------------------------------------- 8635_Tthe QNSQIKRNYSQQITPKEMQTNSNIQ---KLEYA----------------NRISQLCAKGD PLK4_Hsap ------------------------------------------------------------ 5034_Tthe QQYKINQEYNQNKLSNDFSSNNNKMNNNYVSNKINTEYNTNKMINHDNPNRMSNEINKSN 21183_Tthe NQIIINQNIQRQKPSKSTHNN----DNNHTSFDIS------------------------- SAK_Spur ------------------------------------------------------------ PLK4_Mmus ------------------------------------------------------------ SAK_Dmel ------------------------------------------------------------ zyg-1_Cele ------------------------------------------------------------ AqueK201_Aque ------------------------------------------------------------ 8635_Tthe HNFLLEKKSSSNSNNNCQQ--------------NVQSSKNIRSLSNSQF----------- PLK4_Hsap ------------------------------------------------------------ 5034_Tthe VDHYSNKNNSDFNKINVDYNSNKINYDPNKANIDYSSNNKINIEFNSNNKINNGYVSNKV 21183_Tthe ---YLKLDSSQMNSFSVER--------------DFQSTAQFSSKSNVIHTPTNVSISQKP SAK_Spur -----------------------------------------------------------Q PLK4_Mmus ------------------------------------------------------------ SAK_Dmel -----------------------------------------------------------I zyg-1_Cele ------------------------------------------------------------ AqueK201_Aque ------------------------------------------------------------ 8635_Tthe ----------------------------TINSNIKQ------------------------ PLK4_Hsap -DNIS-RYSFDN-LPEK-------YWRKYQYASRF--VQLV------------------- 5034_Tthe TSEVN-KYNYES-NHNKYGNEQNQYKIKYEFSSPK--MNTEQNTSRLNTDYKGTRLNTDF 21183_Tthe PSNKN-SYTYRDINPPSFAPSQQPTSLMRAKGSSKEYIKTEPCDIDVNQTPRLECLETE- SAK_Spur DSGIT-KHSYHD-LPSK-------YWKKYQYASRF--IQLV------------------- PLK4_Mmus -DNIS-RYSFDN-LPEK-------YWRKYQYASRF--IQLV------------------- SAK_Dmel PSGDC-VYNYDN-LPSK-------HWKKYIYGARF--VGLV------------------- zyg-1_Cele -NNPFVYTSYSQ-MPKE-------VQNDYMRLQKM--VAVT------------------- AqueK201_Aque ------------------------------------------------------------ 8635_Tthe ------------------------------------------------------------ PLK4_Hsap ---------------------------------RSKSPKITYFT----RYAKC-ILMENS 5034_Tthe NNTRDNTECNTQRLNTEQNTARLTTEQYNPQRVISKNKAIMF----SMDNLQGKLNMENA 21183_Tthe ------------------------------------------------------------ SAK_Spur ---------------------------------RSKTPKVTLYT----PHAKC-MLMENG PLK4_Mmus ---------------------------------RSKTPKITYFT----RYAKC-ILMENS SAK_Dmel ---------------------------------KSKTPKVTYFS----TLGKC-QLMETM zyg-1_Cele --------------------------------ISGRVAKVTFRRPSQFPDAQA-QLMENG AqueK201_Aque ------------------------------------------------------------ 8635_Tthe -------------------KIQKDTSELS----------------IQVTDRQ-------- PLK4_Hsap PGADFEVWFY------DGVKIHKTE-D-F----------------IQVIEKTG------- 5034_Tthe NN---RISVEQNINGRFNNEIMKTNNENLILKNGNAQNILNTNAHPKIIDKKQKSEVPLI 21183_Tthe ------------------------------------------------------------ SAK_Spur PTADCEACFY------DGTKIHATS-V-E----------------LEVTESNG------- PLK4_Mmus PGADFEVWFY------DGAKIHKTE-N-L----------------IHIIEKTG------- SAK_Dmel --TDFEIRFY------SGAKLLKTPSE-G----------------LKVYDRNG------- zyg-1_Cele ---DLRIKLP------RSVIVRKMD-N-------------------------G------- AqueK201_Aque ------------------------------------------------------------ 8635_Tthe --------------ITFQGNEQNEKINFTK-----------------------SPTQIQT PLK4_Hsap -------------------------------------------------------KSYTL 5034_Tthe SQIANQPMRSSQVQLTQQQQQQNIPITFLNEDRDLYKKQEKFDKVKHFKNQTSDNANYSL 21183_Tthe ---------------------NNENT------------------------STAACSKYSM SAK_Spur -------------------------------------------------------QTCKL PLK4_Mmus -------------------------------------------------------ISYNL SAK_Dmel -------------------------------------------------------MLLSD zyg-1_Cele -------------------------------------------------------EIFNC AqueK201_Aque ------------------------------------------------------------ 8635_Tthe RNNSKSFSQSVNCAPIASSKERKVSFV-AQSA-DLQEQ---------------------- PLK4_Hsap KSESEVNSLKEE---------IKMYMDHANEGHRICLALESIISEEERKTRSAPFFPIII 5034_Tthe NNTNNINGSNEY---------NKEFFN-AQYQQQLQDQQEKMMNSKVNTYRNSQIFESQV 21183_Tthe NTTNRSFNKGLN---------TSKSFS-SFIA-DQTNEIDKYSNNIQLNQQNSNIITSQI SAK_Spur PADQNNDQIPSH---------LKPIISSFYTWRQHCVDVESAIASLESRHGYGPFFPLIL PLK4_Mmus KNENEVTSLKEE---------VKVYMDHANEGHRICLSLESVISEEEKRSRGSSFFPIIV SAK_Dmel YSCSES----------------RSLIEHGNECFTHCVNISNALEVA--QTKDNSCFPVTI zyg-1_Cele ID--GIATQKQAV--------SGITLTKVNEVYKYLIRFEQCLNGM---DRGMVCFPIVF AqueK201_Aque -------------------------------------KLS-------------NCF---- 8635_Tthe ----I-QII--------------------------------------------------- PLK4_Hsap GRKPG-STS--------------------------------------------------- 5034_Tthe GTQRV-QAV--------------------------------------------------- 21183_Tthe SPVKV------------------------------------------------------- SAK_Spur SRKPL-QESYQQGNKLPASTN-IRTSAVTSHTTPATTTTTSTTTVPPSTTPHPSGPTQAC PLK4_Mmus GRKPG-NTS--------------------------------------------------- SAK_Dmel GRRPI-TDV--------------------------------------------------- zyg-1_Cele SAGTNMVGS--------------------------------------------------- AqueK201_Aque SGE--------QSVSFSLKDNDVPSSSVYSQRDPVTC----------------------- 8635_Tthe ------QSKSTQQTG--------------------------------------------- PLK4_Hsap ------SPKALSPPPS-------------------------------------------- 5034_Tthe ------KSKSRIQSGL-------------------------------------------- 21183_Tthe --------------GD-------------------------------------------- SAK_Spur PQGSVTSPSVMAAPTASVCSFDGTICSVARSVQGKDRTRHRKIDKGGSSKEASKVTSQAS PLK4_Mmus ------SPKALSAPPV-------------------------------------------- SAK_Dmel ------QPAQRL-DGL-------------------------------------------- zyg-1_Cele ------SPSSLMPSGS-------------------------------------------- AqueK201_Aque ------------------------------------------------------------ 8635_Tthe ------------------------------------------------------------ PLK4_Hsap ------------------------------------------------------------ 5034_Tthe ------------------------------------------------------------ 21183_Tthe ------------------------------------------------------------ SAK_Spur SHPEGKDGVLKSVFVPNIGWASQMSSGEVRVQYNDGSMILVHAATSTIKYMDSQGKGQRA PLK4_Mmus ------------------------------------------------------------ SAK_Dmel ------------------------------------------------------------ zyg-1_Cele ------------------------------------------------------------ AqueK201_Aque ------------------------------------------------------------ 8635_Tthe ----------------------------------------------------------AV PLK4_Hsap ----------------------------------------VDS-NYPTRERASFNRMVMH 5034_Tthe ----------------------------------------------------------KT 21183_Tthe ----------------------------------------------------------DL SAK_Spur QWKKWIRWRQHCVDVESAIASLESRHGYGPFFPLILSRKPLQE-SYQQGNKVTASKNIRT PLK4_Mmus -----------------------------------------DP-SCCKGEQASASRLSVN SAK_Dmel ----------------------------------------RDTTNIAF------------ zyg-1_Cele ----------------------------------------SQTSRF------PFSNLSNN AqueK201_Aque ------------------------------------------------------------ 8635_Tthe NFA-DSKTQYQSNDTNSSFPVSPLSTQGLKANK------------VNTKNGIIE-----I PLK4_Hsap SAA-SPTQAPI---------LNPSMV-----TNEG---------------------LGLT 5034_Tthe DVS-DSETNSISNQNSTTNNLEYYE-----SPR------------INTLNLMLSPERRIP 21183_Tthe DVS-----------------------------K------------IKTKNGYIE-----I SAK_Spur SAA-TSHTTPATTATS-TNTVPPSTT-----PHPGGPTQACPQGSVTSPS------VMAA PLK4_Mmus SAA-FPTQSPG---------LSPSTV-----TVEG---------------------LGHT SAK_Dmel -------STPKSNQGS----INFSLS-----TI--------------------------S zyg-1_Cele QPSLVPHSAPF---------LTKPT----------------------------------S AqueK201_Aque ------------------------------------------------------------ 8635_Tthe SEN------------------------NWLSIECQNGQL--------------------- PLK4_Hsap TTA------------------------SGTDI------------SSN--------SLKDC 5034_Tthe TTN------------------------NSTAVKN-NSQMKNLLSGNKDNSSCKNNSNNTS 21183_Tthe TSD------------------------HSLLVESCNGRL--------------------- SAK_Spur PTASVCSFDGTICSVARSVQGKDRTRHRKTDK------------GGSSKEACKVTSQASS PLK4_Mmus ATA------------------------TGTGV------------SS-------------S SAK_Dmel STR------------------------NTSDF------------GTN--------CSRSN zyg-1_Cele SQR------------------------AS---------------SAN--------V-QRR AqueK201_Aque --------------ISR------------------------------------------- 8635_Tthe IFKISPNGEQV---------------------------------------------VCQT PLK4_Hsap ---LPKSA-Q-------------------------------------LLKSVFVKNVGWA 5034_Tthe RKNTSKQNNNLKWNDRNNRRKRIHSSVNLKKHNDGDFSRWQRCHVDKVRRAFKQKTLQKN 21183_Tthe LFKISKDGQKIQINKLIDKPMEKHYTLNN----LPAKYYALYGY---------AKQVINA SAK_Spur ---HPEGKDG-------------------------------------VLKSVFVPNIGWA PLK4_Mmus ---LPKSA-Q-------------------------------------LLKSVFVKNVGWA SAK_Dmel ---MLAAHQN------------------------------------IPIKRINVPEIGIA zyg-1_Cele ---VSTDEN--------------------------------------SSPSVAPSKYKIK AqueK201_Aque ------------------------------------------------------------ 8635_Tthe LKS-KTPLVKIQNEKGTFMLMSNQPKQNYEVSLSNGYKVSHVIGTDIMTVKDKQNKEFIV PLK4_Hsap TQL-TSGAVWVQFNDGSQLVVQAG-----------------------------VS--SIS 5034_Tthe AQD-KSAKVKLENEDGQFYLYENK----FEGVFSNGFIVNYKLNSQNLEIQTNKYAPKIV 21183_Tthe LKT-KKVISKLENKEGIFILLENN---CFEAQFKTGYKIYYKNKNASMKIKAPDNNIYEI SAK_Spur SQM-SSGEVRVQYNDGSMILVHAT-----------------------------TS--TIK PLK4_Mmus TQL-TSGAVWVQFNDGSQLVVQAG-----------------------------VS--SIS SAK_Dmel TEL-SHGVVQVQFYDGSVVSVIPS---------------------------MQGG--GIT zyg-1_Cele IDPTTQKVRSIQATDGRVLRCST----------------------------SKAD--QFI AqueK201_Aque ------------------------------------------------------------ 8635_Tthe YLSQQ--NL------NKSIPQEITLAVKVSLEQMSSCLQKQ------------------- PLK4_Hsap YTSPNG--QTTRYGENEKLPDYI---K-QKLQCLSSILLMF------------------- 5034_Tthe F-DLQ--KD------LKHASKEMKTIVQ-KTQKIISII---------------------- 21183_Tthe --SLE--KN------SKDFPQEVKNITS-KSLKYYEYLLN-------------------- SAK_Spur YMDSQG--KGQSYGRNAVLPSHI---R-EKLLHMPHIIQLF------------------- PLK4_Mmus YTSPDG--QTTRYGENEKLPEYI---K-QKLQCLSSILLMF------------------- SAK_Dmel YTQPNG--TSTHFGKGDDLPFPV---R-DRVGQIPNIQLKLKTAPLLGSGRKTDYNNAMT zyg-1_Cele FTDPAIRPDDQRFMRTDRVPDRA---S-EMLHTLCER----------------------- AqueK201_Aque ---------------NSSLDSSV---S-ERRTT--------------------------- 8635_Tthe ----NEQYLANFK PLK4_Hsap -----SNPTPNFH 5034_Tthe --------TSMKS 21183_Tthe -----QNKEFQNI SAK_Spur -----VN-QNKPT PLK4_Mmus -----SNPTPNFQ SAK_Dmel PKTTTPYYNRMLL zyg-1_Cele -------MRKLHQ AqueK201_Aque ---ANSTMVSKCI