CLUSTAL W (1.83) multiple sequence alignment SMG1_Hsap MSRRA----------PGSRLSSGGGGGGTKYPRSWNDWQPRTDSASADPDNLKYSSSRDR CG4549_Dmel MKNAI----------HPE-NCNGAGT---EE----------------------------E SMG1_Mmus MSRRA----------PGSRLSSGGG--GTKYPRSWNDWQPRTDSASADPDTLKYSSSRDR smg-1_Cele MITSR------------------------------------------------------- SMG1_Ddis MNDSN----------SSNDSCNTENNTLTATKNSINNTTTTTTTPNNNVNCLKTSGSIKL SMG1_Spur ------------------------------------------------------------ AqueK047_Aque MLYTT------------------------------------------------------- SMG1_Smoe MAEMLLQTLASQVRAAHTFDDHGGG-GGAAV----------------------------- SMG1_Hsap GGSSSYGLQPSNSAVVSRQR----------------------------HDDTR------- CG4549_Dmel ASS-------AFHAEIDRVL----------------------------LNNNG------- SMG1_Mmus GVSSSYGLQPSNSAVVSRQR----------------------------HDDTR------- smg-1_Cele ------------------------------------------------------------ SMG1_Ddis SAS-SVPFIPGSSASLPSILSNQYKLAASNNVSNNIMMISTPIISSAQQQQQQVPPPQQT SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe ------------------------------------------------------------ SMG1_Hsap ---------------------------------------------VH------------- CG4549_Dmel ---------------------------------------------NH------------- SMG1_Mmus ---------------------------------------------GH------------- smg-1_Cele ------------------------------------------------------------ SMG1_Ddis TTTTTATATAITPTPITTSQSTSSSMLNLPLKVGKESIETLFRNRFHPKNNIRETVLSSL SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe ------TAAALPPPPLLPSVQV-CTLLK-------------------------------- SMG1_Hsap --------ADIQN--DEKGGYSVNGGSGENTYGRKSL----------------------- CG4549_Dmel --------GDSSN--EGGGGNGSGRGGATGSGNIAGLGGS-------ESMWSPGGGKSHD SMG1_Mmus --------ADIQN--DEKGGYSVNGGSGENTYGRKSL----------------------- smg-1_Cele ------------------------------------------------------------ SMG1_Ddis QSILIPDLSDTINNTKENIEYFYNMIIDENNYILKLLLLNIINDTKRN--LVVY------ SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe --------MNLQMLA--AQGLALHPSAALRLLETGSPFSN----------------LRLH SMG1_Hsap -----GQE--L-RVNNVTSPEFTSVQHGSRALATKDMRKSQERSMSYSDESRLSNLLRRI CG4549_Dmel VAQAFANALLLRNMNHVVGKGQPVVQNHRKAYQCK---GDTINPMANGEDLRLSKIIRRL SMG1_Mmus -----GQE--L-RINNVTSPEFTSVQHGSRALATKDMRKSQERSMSYSDESRLSNLLRRI smg-1_Cele -------------------------------------------------NNDIGNLIEQF SMG1_Ddis -NYNQQHQ--L-PIQNTSSPNTPSSTTTTTTTSTKPS--------------------KRG SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe P----CQAI----TSSVAATYVYFLQHGCEKVAVE------------------------- SMG1_Hsap TREDD-RDRRLATVKQLKEFIQQPENKLVL----VKQLDNIL--AAVH----DVLNESSK CG4549_Dmel INENN-PTVSLELCSKLDQAVRTPINMGYMTCSFVWILDNML--TLYKQCPPPVLEECSK SMG1_Mmus TREDD-RDRRLATVKQLKEFIQQPENKLVL----VKQLDNIL--AAVH----DVLNESSK smg-1_Cele RQRDTPQKERKAILARIEEILQTTKNVESLCVKWTYLLDNLCWPSLTKHDRNDMKTLAGK SMG1_Ddis DKERE-RGRRNKDKINEKQLQQQQLQQLQL----QQQLDHEG--SSLY------------ SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe ------------------------------------------------------------ SMG1_Hsap LLQELRQEGACCLGLLCASL--SYE--AEK-IFK-WIFSKFSSSAK--DEVK-----LLY CG4549_Dmel T-----------LGLI-GFI--NRK--SYP-IYEEFIVKNYKSSKR--MQK--------Y SMG1_Mmus LLQELRQEGACCLGLLCASL--SYE--AEK-IFK-WIFSKFSSSAK--DEVK-----LLY smg-1_Cele VIR-----------L-VGVLLFDTE--SYP-EFLIYLGTLYQSVTKKSEETRADIVFSVY SMG1_Ddis -----------------------------------LPFSSLLSFIK--PD---------- SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe --------SALCLKREIETL--SRSLAGKKGAMG-LVEAEVVSLLK--FD-------LLL SMG1_Hsap LCATYKALETVGEKKAFSSVMQLVMTSLQSILENVD--TPELLCKCVKCILLVARCYPHI CG4549_Dmel MIMALRATLSCDTKCELHMYADKIMLLLKDFLENAE--SADIFIVVSNTLVQFAASYAET SMG1_Mmus LCATYRALETVGEKKAFSSVMQLVMTSLQSILENVD--TPELLCKCVKCILLVARCYPHI smg-1_Cele FIVGV--ISQKTENRLIATDTENVEKSLDWIIKVLPNSSISVYNHCLKGFVLVANTFPNV SMG1_Ddis ----KQQQPQQSQQSQLNEIDQMVRPK--------------SLPK--------------- SMG1_Spur ------------------------------------------------------------ AqueK047_Aque -------------------IM--------------------------------------- SMG1_Smoe LLMSVRANA-------AESQVQKVKSIINFVLEKSD--P--------------------- SMG1_Hsap FSTNFRDTVDILVGW-HIDHTQKPSLTQQVSGWLQSLEPFWVADLAFSTTLLGQFLEDME CG4549_Dmel FECHFTDVVDIVIGW-QLEAGQPTDLKTHCAQVLEQLTPFFSKQIDFSYGLLDQFVEDIT SMG1_Mmus FSTNFRDTVDILVGW-HIDHTQKPSLTQQVSGWLQSLEPFWVADLAFSTTLLGQFLEDME smg-1_Cele YAAMFESTLRAIL---------------------TNLPDFNSHEKNFE------------ SMG1_Ddis -DDNDSDNFNIRVLEYN--LKLLIKIYFKVSMYQ----------DSIKTHIFDLYIQINQ SMG1_Spur ------------------------------------------------------------ AqueK047_Aque --------------------------------------P--------------------- SMG1_Smoe --------FEAPVRW-HSE----------------------------------------- SMG1_Hsap AYAEDLSHVASGE---SVDEDVPPPSVSLPKLAALLRVFSTVVRSIGERFSP-------- CG4549_Dmel TLEEG------------------EPANTAERVGAFVGAFNTLLKCLA-RMQI-------- SMG1_Mmus AYAEDLSHVASGE---SVDEDVPPPSVSLPKLAALLRVFSTVVRSIGERFSP-------- smg-1_Cele ----------------------------------------LLIDTVM-RFSDQLNEKPHL SMG1_Ddis AISEQQRQLQEKEKESKTSKPIPQPIISL--------VIPTVLVSIGDIIKY-------- SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe --------------------------LQLAVVQALRRVFSWIVPWEVD------------ SMG1_Hsap --I----RGPPITEAYVTD--VLYRVMRCVTAA-NQVFFSEAVLTAANECVGVLL----G CG4549_Dmel --F----VGMPTCECIVKM--AVDHLIKIMP----TLHLNTEALVNINELICICLLNNFT SMG1_Mmus --I----RGPPITEAYVTD--VLYRVMRCVTAA-NQVFFSEAVLTAANECVGVLL----G smg-1_Cele AEEMVRIIRPDIKKNGLGNMRELKKRMKLTMAL-VKMAKSQKMLEETNQMISEMS----I SMG1_Ddis --KYATPSPPNLTPTTTTK---MEEEER-------------------------------- SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------VF---------------------- SMG1_Smoe -------------------------------AEGAMEFFG-------------------- SMG1_Hsap SLDP---------SMTIHCDMV---ITYGLDQLE----------------NCQTCGTDYI CG4549_Dmel GLDP---------IL---LEQV------LLDQVK----------------RMISLTELQR SMG1_Mmus SLDP---------SMTIHCDMV---ITYGLDQLE----------------NCQTCGTDYI smg-1_Cele ELEENGGKWSSASLITIVCDVFNELLILGKDDVKLQKGVEESLCNVLKDLNLSNQSTMEK SMG1_Ddis ------------------------------------------------------------ SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe ------------------------------------------------------------ SMG1_Hsap ISVLNLLTLIVEQINTKL-PSSFVEKLFIPSSKLLFLRYHKEKEVV-AVAH-AV--YQAV CG4549_Dmel QSVLYLLLCTVRRLRARL-TPSLVHFIFQSNPYMTKVRLRSPGETSYKLLL-RT--CQET SMG1_Mmus ISVLNLLTLIVEQINTKL-PSSFVEKLFIPSSKLLFLRYHKEKEVV-AVAH-AV--YQAV smg-1_Cele QAFFNSLAKIVKQLPAESQVKTRVHQIVFNTETGLFTPKN--RDNR-MFGHNMI--YKDL SMG1_Ddis ------------IINTIL-INEF-----------------KKTDVS-IIES-NLYLFECI SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe ------------------------------------------KCS-VAMAR-GL--EKGV SMG1_Hsap LSLK-NIPVLETAYKLILGEMTCALNNLLHSLQLPEACSEIKHEAFKNHVFNVDNAKFVV CG4549_Dmel LLIR-NVPLLQQAYKYLVDDIDACLEKLLITAPRS----------------KARKASVLL SMG1_Mmus LSLK-NIPVLETAYKLILGEMTCALNNLLHSLQLPDACSEIKHEAFQNHVFNIDNANFVV smg-1_Cele INLV-SVLLTPTSLNHLQATYTD-LRKI-----MIDSMSRLKQSEDTPYSDNIRWNESIL SMG1_Ddis LSI------------------------------------------------SVSNEPTIV SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe ASLTVRIEVLEW------------------------------------------------ SMG1_Hsap IFDLSALTTIGNAKNSLIGMWALSPTVFALLSKNLMIVHSDLAVHFPAIQYAVLYTLYSH CG4549_Dmel VFHLSALAALAKQTSSIIGMYACKPSILELLLTNCRAHELKFWSKYPAAQQAIFGLLVVH SMG1_Mmus IFDLSALTTIGNAKNSLIGMWALSPTVFALLSKNLMIVHSDLAVHFPAIQYAVLYTLYSH smg-1_Cele LLFFSSLQSISCAKSSLIVMMGIRPSIFEFFSSELPLTEYWLASNHPEVYHLFITIFVGH SMG1_Ddis VPNTTTATTATTATTSNTSTAAAATTTTPTLS---------------------------- SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe ------VGEFPKWFRKLEGMTLLSSSLFVA------------------------------ SMG1_Hsap CTRHDHFISSSLSSSSPSLFDGAVISTVTTATKKHFSI--ILNLLGI-LLK-KDNLNQDT CG4549_Dmel CQANHNFRTNS-----SLLRDQELSAENTSPTANSFAS--ILRFLDSVLGQ-AHQLAPQN SMG1_Mmus CTRHDHFISSSLSSSSPSLFDGAVISTVTTATKKHFSI--ILNLLGI-LLK-KDNLNQDT smg-1_Cele LKAHDFYIVQS-----DYIVRGDSIGQSIGQTKRDYARKQVVALQKI-INNFGDKLWKKT SMG1_Ddis -------------TSSSSLSPPASTQSSLSLSSS-------------------------- SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe ------------------------------------------------------------ SMG1_Hsap RKLLMTWALEAAVLMKKSETYAPLFSLPSFHKFCKGLLANTLVEDVNICLQACSSL--HA CG4549_Dmel LRVLLQWIQM--LLRECREKIDLLMEQENFRGICRNIAA-TASKLVPLESAACIQ----- SMG1_Mmus RKLLMTWALEVAVLMKKSETYAPLFSLPSFHKFSKGLLANTLVEDVNICLQACSSL--HA smg-1_Cele RLMISSWLHSLIATACEHQIGSDSFSQREWVRLRNTVIHQSVLTWNNECVNQALTI--LS SMG1_Ddis ---------SSAVIAPTTVGYIFKFNKELFRKLI-ALVYSTVVQH-QITLSTVFTT--LV SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe ------------------------------------LVAAASDEEHTVRLQASKTFGALL SMG1_Hsap LS---SSLPDDLLQRCVDVCRVQLVHSGTRIRQAFGKLLKSIP--LDVVLSNNNHTEIQ- CG4549_Dmel ------TVLDYGLERLEKYPKLLILYRDTALQQL-------------QMLSTNYHAPYF- SMG1_Mmus LS---SSLPDDLLQRCVDVCRVQLVHSGTRIRQAFGKLLKSIP--LDVVLSNNNHTEIQ- smg-1_Cele TATKWSELTSDIHRDIADKTKKAKWKEATTIWE-----------------SGDCNTYIR- SMG1_Ddis LK---GYLNEDQIQKLLNITLFKLSDPSEQVKLSYLTLLSKMVSYFDLNHQKNLNHKVN- SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe RH---KCLSSSQLYSVASAAFEQLGDPDPGIQAAFREVLATCA--LGALWVHGWNSDLDA SMG1_Hsap --------EISLALRSHMSKAPSN-TFHPQDFSDVISFILYGNS---------------- CG4549_Dmel --------QIYAQLPLHLTLTGGE-SSMPGMASRRVSVWQQRISQYSAVRDNVFRDFFDR SMG1_Mmus --------EISLALRSHMSKAPSN-TFHPQDFSDVISFILYGNS---------------- smg-1_Cele -Q--SMSTVYQMSQERQQKTITST-SFGAEEFIIITNFLLKQATP--------------T SMG1_Ddis --------DISLPYKLLIMGSTSQPFFNGQIFKKIFDWIMGIGK---------------- SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe KEEGNFVTKRPLEREKHWRSVLSANRFALQLSPPQVVCILNYISQRP------------- SMG1_Hsap -HRTGKDNW---LERLF----YSC-----------------------------QR----- CG4549_Dmel VQKPEQDSLIHCLRELF---VRSC-----------------------------QV----- SMG1_Mmus -HRTGKDNW---LERLF----YSC-----------------------------QR----- smg-1_Cele TFKKGQNSW---MDEVLETFTQGC-----------------------------RT----- SMG1_Ddis -DQPSFDSLTKYLIDLF----DSFNVISILFNEQNKILSQQYLAAQSTMITPPLS----- SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe --QSLPAGW---QQRLV----FNC-----------------------------LKTKSAD SMG1_Hsap -------LDK-RDQS-TIPRNLL---------KTDAVLWQ-WAIWEAAQFTVLSKLRTPL CG4549_Dmel -------AP-QDERQMNLSQCTK---------RCQRLAIA-WLQFEAARYCVDQRLRTTV SMG1_Mmus -------LDK-RDQS-TIPRNLL---------KTDAVLWQ-WAIWEAAQFTVLSKLRTPL smg-1_Cele -------LEK-PD-S-YVPETFI-------------EKWD-WIINQTANFCIVNKMKTPL SMG1_Ddis -------LHQIDDRR-KFETLIS---------KSDELIWF-WTVWECSKFCIANRLKSPY SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe DKKQGDGLDR-KEDF-SVVEDAARFDLVESWCCSSNMAAAWFIIQELARHCITVRFRTHL SMG1_Hsap GRAQDTFQTIEGIIRSLAAHTL---NPDQDVSQWTTADND-E---GHGNNQLRLVLLLQY CG4549_Dmel GKPQETFLGFEAIIMRHARLLS---GCAKEIERSALDDLSLE---ELLSMQSNLSLLLGF SMG1_Mmus GRAQDTFQTIEGIIRSLAAHTL---NPDQDVSQWTTADND-E---GHGSNQLRLVLLLQY smg-1_Cele GKPMQTFAAFENEIKRLAKEVIVRKNSDKKLNKSSTEDPNQSPPLKYSVQWLRVHLLLKL SMG1_Ddis GSAFQTFEIFEKLLLQLNKDR---------------------------RDFKKIKILLHF SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe GGPTQTFAALERMLLDLPQLVQ---S-----------ESS-A---ANTSELLPMRLLLEL SMG1_Hsap LENLEKLMYNAYEGCANA--LTSPPKVIRTFFYTNRQTCQDWLTRIRLSIMRVGLLAGQP CG4549_Dmel LDALEKLIYNAAEGSAFA--LRPPEKQVAAFFRLNNPTCQSWFNRIRIGVVIIAMHVQQP SMG1_Mmus LENLEKLMYNAYEGCANA--LTSPPKVIRTFFYTNRQTCQDWLTRIRLSIMRVGLLAGQP smg-1_Cele IVVLEKLMNSAIHGGSSVFNLTEIPVSSRQFFTVNAASCEVWLNRVYYPALLVAYFNGYY SMG1_Ddis MESMEKLIFSTVNGSVLV---QSLNNKETQFFRHNVRVCEDWFSRIRVNLLKASILSSST SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------FTRV-------------- SMG1_Smoe VDSLQRNIYNAYEGSL-V--LEAPSFSSGLFFRANKKVCEEWFARIREALVNASSVIQCH SMG1_Hsap AVTVRHGFDLLTEMKTTSL----------SQ--GNELE--------VTIMMVVEALCELH CG4549_Dmel ELVIRYAQQILVNSKT--------------Q--DPTYS--------QAIVYMAWSLVSCQ SMG1_Mmus AVTVRHGFDLLTEMKTNSL----------TQ--GSELE--------VTIMMVVEALCELH smg-1_Cele GLVIRFGSNALSHFARQKD---------------GDNDKKIVNGV-CTASLMSLSMAVLG SMG1_Ddis PDIIRHASLRVQDIQANRFVLD-----SNTA--HFELE--------FCILHLANALQQLN SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe FGTAQHALFRLHDLRPMALAALRDLPRSQAADGGLSLKVKLQQDVFRVLRHGSLALCKLH SMG1_Hsap CPEAIQGIAVWSSSIVG--------------------------------KNLLWINSVAQ CG4549_Dmel EADSLRGLRLWARGKSC--------------------------------KSYKWLKYAAD SMG1_Mmus CPEAIQGIAVWSSSAVG--------------------------------KNLLWINSVAQ smg-1_Cele EPMEIVGLRRKVREEFGTDM------------------------------GQSLMEALGE SMG1_Ddis ETESLQGLSNWSDINLNNSDN-NNNNNNKNNNNNNNSTFFNNGNINKYTLKLPWMKGVIL SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe ESDSILGLQAWAVTAFAGLILED------------------VHKVSSPLGPVGWMNGLAF SMG1_Hsap QAEGRFEKASVEYQEHLCAMTGVDCCISSFDKSVLTLANAGRNSASPKHSLNGESRKTVL CG4549_Dmel QAAGKRESALAGYRTILAEKE--------------------------------------- SMG1_Mmus QAEGRFEKASVEYQEHLCAMTGVDCCISSFDKSVLTLANAGRNSASPKHSLNGESRKTVL smg-1_Cele MANARYETALVALEAVLVTDA--------------------------------------- SMG1_Ddis RSKQKFEESISSLLSVPPM----------------------------------------- SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe EARGEFERAAAHYSQLFQSEE--------------------------------------- SMG1_Hsap SKPTDSSPEVINYLGNKACECYISIADWAAVQEWQNAIHDLKKSTSSTS---L--NLKAD CG4549_Dmel -LQSELEPHTRQFVVSQMMQCLQDLGQWSQLVELKQQQMTRPEDRELNP---FLQRSNVE SMG1_Mmus SKSIDSSPEVISYLGNKACECYISIADWAAVQEWQNAVHDLKKNSSSTS---L--NLKAD smg-1_Cele -----ATNETLKMIIQL---AMVDILNRIRLPQATDYYKVVLFGEESND---S--TITED SMG1_Ddis ---LESNSISFPFVLEQIIKSYLDISNFTEVEQFLQNYQNQIQQQ-SNS---L--IIYKD SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe -TLSVLGADGVQFIIGRIVESYVSLSDWEALEGWLQELQVLRAKHAGKSYTGALTTAGID SMG1_Hsap FNYIKSL--------SSFESGKFVECTEQLELLPGENINLLA---------------GGS CG4549_Dmel VNALERLLAKSEESCSSMD--ALGGVFQQLSLWPSNWDESVSSSGLSERASFSSIHMRQR SMG1_Mmus FNYIKSL--------SSFESGEFVECTEQLELLPGENINLLA---------------GGS smg-1_Cele FRSVELL--------TKFEKLN---------NTVNEKRQV-------------------- SMG1_Ddis -TFIKTL--------GSFYRGEMEEAHAFAKRTESQNH-I-------------------- SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe MNSIHAL--------SRFDASDMEGTWGYLDLTPQSN----------------------- SMG1_Hsap KEKIDMKKLLPNMLSPDPRELQKSIEV---QLLRSSVCLATALNPIEQDQKWQSITENVV CG4549_Dmel TEDIVLHKLLEDRCVPDQAK--NLLDT---QW-RD-----SLLNPSFDQRSCKEL----- SMG1_Mmus KEKIDMKKLLPNMLSPDPRELQKSIEV---QLLRSSVFLATALNHMEQDQKWQSLTENVV smg-1_Cele -------------VDWSARERFQFVESAFSQTMRRRVSRVTELLDIQKD----------- SMG1_Ddis -------------------------------LQREQLGLGLLGNQIMTDELLLSIMVNQK SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ----DMI----------------------------------------------------- SMG1_Smoe -----------NEITIDPRQALQRSEQ---MLLQAML-------------RKDSEVEDAA SMG1_Hsap KYLKQTSRIAIGPLRLSTLT-VSQSLPVLSTLQLYCSSALENTV--SNR-LSTEDCLIPL CG4549_Dmel TLLRHIVQGVSGGQELSLLP-VSSGR--CQNR---------------------------- SMG1_Mmus KYLKQTSRIAIGPLRLSTLT-VSQSLPVLSTLQLYCSSALENTV--SNR-LSTEDCLIPL smg-1_Cele -----F--SAMGALALSADS-SCKLYSDISSTSLIIANLVNKM----------------- SMG1_Ddis DLFNNTNIINNNNSGGSSSG-TATATAVTTTTTTTTTTTTTTTT----T-TNTNNDII-G SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ----------------------------------------ENSP--S------------- SMG1_Smoe REVKLARAMLDGPLLVSSLDDLSDAAPYLT--QLHCIEVVESWKGPSERQEGIQDISLKY SMG1_Hsap FSEALRSCKQHDVRPWMQALRYT-----------MY----QNQLLEKIK-EQTVPIRSHL CG4549_Dmel -SKFISSAILMRCLAWTQLLRQH-----------------------------CAP--GSW SMG1_Mmus FSDALRSCKQHDVRPWMQALRYT-----------MY----QNQLLEKIK-EQTVPIRSHL smg-1_Cele ----------TGVSQWKNKLTD---------------TEIFDRNEEGND-GDKLAICRKL SMG1_Ddis FSNNINSMLKLTKNNILKALNYLGLESNVQTFQYLTQLKIMDEIENGVYNSRVVPINNQI SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe FNHPADEV-YQDCHLWLKVLRVY-----------K----------------TVFPHAGVT SMG1_Hsap M---------------------------ELGLTAAKFARKRGNVSLATRLLAQCSEVQLG CG4549_Dmel E---------------------------TLCLDAAAAAREEGNLQLAETLLTQFFGQPIG SMG1_Mmus M---------------------------ELGLTAAKFARKRGNVSLATRLLAQCSEVQLG smg-1_Cele MHWGRHTKSNRGQS-CAAH------------SEIIRLSRKTSNCELAFFHI--------- SMG1_Ddis GFL-ERLRRVRGHISNTKQRSDILLSNIPLTEKMIKLSRKFENYKFSSKLLDT------- SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe S---------------------------TLRRQLIRLARKHGNFRLARRMLKEMDG---- SMG1_Hsap KTTTAQDLVQHFKKLSTQGQVDEKWGPEL---D-IEKTKLLYT--------AGQSTHAME CG4549_Dmel EIAALFSLEQGVQTD----------NPEMLRGY-SELVKCLHLQQQQSQTHSGDLSSSID SMG1_Mmus KTTTAQDLVQHFKKLSTQGQVDEKWGPEL---D-IEKTKLLYT--------AGQSTHAME smg-1_Cele -------------NSAIRGEKLAAWQ-RL---E-VERQRLKLVKTQNLDVRI---REMNE SMG1_Ddis --------------------ILESHSSSY---Y-LERCKLKYL--------NGKQTEATL SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe ----------------------ENWDSKV---AAYENSLLHFS--------EGQHAKAMT SMG1_Hsap MLSSC----------AISFC--KSVK------AEYAVAKSILTLAKWIQAEWKEISGQLK CG4549_Dmel VCAAL----------CLNIQ--KSNN------QPAAGADLLLNLADWIAVR--------- SMG1_Mmus MLSSC----------AISFC--KSAK------AEYAVAKSILTLAKWVQAEWKEISGQLR smg-1_Cele VFGSL----------AEVFTTSCQLK------SDFQMVDGMIKEKMISEGYNEDIAKREE SMG1_Ddis DLIKYAHRDITIPSSSTTTTTTTTTT------TPPSTSSNTATTTNNI--NIDE------ SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe ELWPL----------VKNFI--AESERALPFEGDVMAATSCLKLGSWLQKRRTE------ SMG1_Hsap QVYRAQHQ--QNFTGLSTLSKNILT-LIELPSVNTMEEEYPR--IESE---STVHIGVGE CG4549_Dmel -----------TCNGLTTNQ---------SPVLIQLLDQLPECPLTCD---SSQPLAIPQ SMG1_Mmus QVYRAQQQ--QNLSGLSTLSRNILA-LIELPSANTVGEEHPR--IESE---STVHIGVGE smg-1_Cele HMSRASIQLADFFQSLPEL-ENVLA-PNLFPTIIW-----------SELQRRSDSLSA-G SMG1_Ddis ---------------LSTQKFKVYTEIIK------YLNSNPS--IITEL--SSSNYSIPQ SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe ----------NDFAGL-----------------------------LSEMDLTSGSGG-MI SMG1_Hsap PDFILGQLYHLSSVQAPEVAKSWAALASWAYRWGRKVVDNAS--------QGEGVRLL-- CG4549_Dmel AERMVARLVHSCLQQRPNYAEALIAYGNWCYRWGKKVADSCCVLTQADATAISQALDIPQ SMG1_Mmus PDFILGQLYHLSSVQAPEVAKSWAALASWAYRWGRKVVDNAS--------QGEGVRLL-- smg-1_Cele YHGIVGSLFHLASEMCPSLAKAHLKMARWAYEIAKI-KNF-------PAENLS-FYKF-- SMG1_Ddis EQLNPEYYFKKATLTKPENSKLWITYADWILNEKSNISEQN------------------- SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe LEEVAGAAVKAATLHCPSFGKAWFSYASWCYSLARCGFFG--------NETLSKASIFPQ SMG1_Hsap PREKS--------------EVQNLLPD-------TITEEEKERIYGILGQAVCRPAGIQD CG4549_Dmel PLESE--------------KLDELLQA-------LSTEQPPANCVEVCP-----DAARAR SMG1_Mmus PREKS--------------EVQNLLPD-------TITEEEKERIYGILGQAVCRPAGIQD smg-1_Cele GKDET--------------ENEELLKSLE--------ATSLVNLEKLVR-----A-AI-- SMG1_Ddis ------------------------------------------------------------ SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe VLEKELISSSPSLTDEEMMKIQAMIKSLGSELEDAILEMLVKRVVFLL-EAAAREAGFEK SMG1_Hsap EDITLQITESEDN--EEDDMVDVIWRQLISSCPWLS-ELDESATEGVIKVWRKVVDRIFS CG4549_Dmel D----------------DEAAKNR----LRRLTFLA-DKTPEALDAILQIWRRAIANTYD SMG1_Mmus EDITLQITESEDN--EDDDMVDVIWRQLISSCPWLS-ELDENATEGVIKVWRKVVDRIFS smg-1_Cele ---------SDDL------------RAN----N------ILAPNSHFMHIWKMVRDHRTK SMG1_Ddis DEESLNGGGSGGNENSSNEMLR-------------------------------LKNTNTN SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe W---------------DGESLSLQLRQEL---QVLKPSSVPGLINELLQVWWGVRKRRIS SMG1_Hsap LYKLSCSAYFTFLKLNAGQIPLDEDDPRLHLSHRVEQSTDD-MIVMATLRLLRLLVKHAG CG4549_Dmel YYKDAARSYFQYLSFKSGSGPEKPEG-EGVVSQRERLHVDDSNLVTTTLRLLRLIVKHAS SMG1_Mmus LYKLSCSAYFTFLKLNAGQVLLDEDDPRLHLSHRAEQSTDD-VIVMATLRLLRLLVKHAG smg-1_Cele FLSIAVTSYFQFIQNMSGDCDN------------LPYSKKE-ETTLATLRILELLVKHGD SMG1_Ddis ELKTAVEAYFQFLKYSMLDG----------------NSNGG-LNIRATLKILNILVCSGN SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe LFGYAAHGFLKYMSLSNRTTV------------RSNPLKQD-STLSASLFVLNILQTCGV SMG1_Hsap ELRQYLEHGLE-TTPTAPWRGIIPQLFSRL-NHPEVYVRQSICNLLCRVAQDSPHLILYP CG4549_Dmel GLQEVLEQGLH-TTPIAPWKVIIPQLFSRL-NHHEPYVRKSVCDLLCRLAKSRPQLVIFP SMG1_Mmus ELRQYLEHGLE-TTPTAPWRGIIPQLFSRL-NHPEVYVRQSICNLLCRVAQDSPHLILYP smg-1_Cele VLIDVINDGLN-KTNVHIWKEILPQLFARL-SHPSEHIRKTLVDLISKICTAAPHAVVFQ SMG1_Ddis KLVETFERCLNELTSTRPFTIIIPQLFARL-SHPDTFVQKYVVEILNRIGRDNPNKIVYQ SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe ELEDILQQGLS-SIPPSPWKEITPQLFACVSSHPEAKVRKQLEGLLMSLANVYPWAIVYP SMG1_Hsap AIVGTISLSSESQASGNKFSTAIPTLLGNIQGEELLVSECEGGSPPASQDSNKDEPKSGL CG4549_Dmel AVVGANREQQD---ATAPPATARPTT------------------------E--------- SMG1_Mmus AIVGTISLSSESQASGNKYSSAIPTLLGNIQGEELLVSECEGGSPPASQDSNKDEPKSGL smg-1_Cele VVSGAASSSTDG---E--------------------------------------ELEEQQ SMG1_Ddis TIVGSLNFTNTNN--NNNSSCAAATT------------------------DDGLDIELLQ SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------------------------------------------------------ SMG1_Smoe TLVHFNASE--GQSSE-------------------------------------------- SMG1_Hsap NEDQAMMQDCYSKIVDKLSSANPTMVLQVQMLVAELRRVTVLWDELWLGVLLQQHMYVLR CG4549_Dmel ------DACCYGYLLGELSKQAPEAVQHVKLMVKELRRVCLLWDEYWIHSLAHIYNTYVS SMG1_Mmus NEDQAMMQDCYSKIVDKLSSANPTMVLQVQMLVAELRRVTVLWDELWLGVLLQQHMYVLR smg-1_Cele NDDRNRVRACCEKLETNMSQSYPNLVKDVRQFVAELERINLLNEEKWSVVMGTMEHEMEK SMG1_Ddis KQYPNYLQ--ILNIKENLLKHSELLVKETETLIYQLGKLTTLWDDNWQYFIEQIQGWVYI SMG1_Spur ------------------------------------------------------------ AqueK047_Aque --ELSSLDRCLAVIVDSLTQKNPIMVKAVRDLVSELCRITLLWDEMWLAALMQRQGEVHR SMG1_Smoe ---------ELERILNSLSKLHPKVVNDVRLMIAELGSITFLWEEQWLTTLQDLHADVTR SMG1_Hsap RIQQLEDEVKRVQ---NNNTLRKEEKIAIMREKHTALMKPIVFALEHVRSITA-APAETP CG4549_Dmel RVSALATDFRPDDHEG------KN-------NRFNVWRPQLLADLEALVAVTS-RPPETT SMG1_Mmus RIQQLEDEVKRVQ---NNNTLRKEEKIAIMREKHTALMKPIVFALEHVRSITA-APAETP smg-1_Cele RLSLIRTENAKTE---SALHLTASVKNDIIVKRTQLLTRQIFDVLDELYQQTVIEPPKSK SMG1_Ddis NTKQWNDDYQQLKATIKNPTILK----HTLKKKNQELLQPIYEKLKRLTAATVLSVCKTP SMG1_Spur ------------------------------------------------------------ AqueK047_Aque RLLQIEAETKRTFA-IHNHVLSMERKEAVMRQKYIATMKPLLWVLEYLAAVTA-QPPETQ SMG1_Smoe RIITLKEEAARIA---ENQTLSPDEKTKINAAKYAAIMAPVSYALERRLTLTS-RPAETP SMG1_Hsap HEKWFQDNYGDAIENALEKLKTPLN-PAKPGSSWIPFKEIMLSLQQRAQKRASYILRLEE CG4549_Dmel YERSFRKRFDAPIRLTVDALRHRRY-P----EAWDKLKQLYHILQSNMIRGSGSTLKMQS SMG1_Mmus HEKWFQDNYGDAIDNALEKLKTPSN-PAKPGSSWIPFKEIMLSLQQRAQKRASYILRLDE smg-1_Cele NEEEFVTAFAEVLTNAFQESRIS-R-TTSPEKSWIPFKNLIANFVHRNSKKGMQTFETED SMG1_Ddis HEKWFTKCHFETINKTIRAFEKQNK-PTS------PFDVLH-DLIAEFQQYRLISLSLSS SMG1_Spur ------------------------------------------------------------ AqueK047_Aque NERQFQAEYGELITMAIQKLQNPSN-YKSSINVWDPFKQLQQMLMHRAQKRMQTPLSLNE SMG1_Smoe HEVWFQEHFGGQLRAAITTFKTPPGGNITLNDVWKPFDAIAASLSNH-HKRSA--VVLQD SMG1_Hsap ISPWLAAMTNTEIALPGEV---------------------------------SARDTVTI CG4549_Dmel ISPVLCGIGRMRISMPGLDA------------------------------HGPDGDQVYI SMG1_Mmus ISPWLAAMTNTEIALPGEV---------------------------------SARDTVTI smg-1_Cele ISPYLASLSNSCVPMPGQES-------------------------------VEFDRVVSI SMG1_Ddis VNPSLALFRPTITQMPGTDLNYFNINHIHHHHHHHNHHGNNNNQHSTSSGNLPIQNQVTI SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ISPHLAAIQSSCISMPGHS---------------------------------QMDEPVLL SMG1_Smoe VSPRLAALTHSDAPMPGLEF--------------------------------PDADLVTV SMG1_Hsap HSVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATI- CG4549_Dmel ESVESSVCVLPTKTKPKKVAFYGSNGQRYTFLFKGMEDLHLDERIMQFLSISNAIMACRS SMG1_Mmus HSVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATI- smg-1_Cele SRVARQVTILPTKTRPKKLGFVGSDGKQVAFLFKGREDLHLDERVMQFLRLCNVMLQPGK SMG1_Ddis QLIKPTIYLLPTKTKPKKMAMLGSDGNLYYYLLKGREDLHLDERIMQLLNVVDQLLMND- SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ESFCLDVSVLPTKTKPKKISMIGSDGRRHTYLFKGLEDLHLDERIMQFMAIVNNMFAKA- SMG1_Smoe ANFNDQITILATKTKPKKVSVTGSDGQVYNYLLKGREDLRLDARIMQLLRASNKMLRAS- SMG1_Hsap --NRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQREAALQ--------- CG4549_Dmel --DAPGNGCYRAHHYSVIPLGPQSGLISWVDGVTPVFALYKKWQQRRSQVA--------- SMG1_Mmus --NRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQREAALQ--------- smg-1_Cele GKHRQSVAAYQAHHYAVIPLGPRSGLIKWVEGATPMFHIYRKWQMKEKALK--------- SMG1_Ddis --KKPTLKLLRTRNYSVIPLSQSSGLIQWVEGAVPLFSIYKNWYKNDQVYKQQQQQQQQL SMG1_Spur ------------------------------------------------------------ AqueK047_Aque --HKHQTQLYLARDYAVIPLGARSGLIQWVDNVTPLFGIYKRWQQREALAK--------- SMG1_Smoe --SATRREGLAVKCYSVTPISGRAGLIQWVDNVTSLYSVYKAWQLRQQAAQ--------- SMG1_Hsap -AQKAQDSY-------------------------------Q--TPQNPGIVPRPSELYYS CG4549_Dmel -GNAGAGA--------------------------------------VANVPRRFTDLFYN SMG1_Mmus -AQKAQDSY-------------------------------Q--TPQNPSIVPRPSELYYS smg-1_Cele -QATKKNGE-------------------------------------TVPEIERPSNMYHN SMG1_Ddis QQQQQQQQQQQQQQPQPQQQPQQQPQQQPQQQPQPQQNSTTTSNIVNKPIIARPVDIFYA SMG1_Spur ------------------------------------------------------------ AqueK047_Aque -AMQQAGSQ-------------------------------P--TAPLQVQVRKPNELFYA SMG1_Smoe -LSSNAVSG-------------------------------------APPPLPRPSDMFYG SMG1_Hsap KIGPALKTVG--LSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELWSSCTTPDEWWRV CG4549_Dmel KLSPLLAKHN--MQVSDPRRQWPISVLLQVLDELSQETPNDLLARELWCQAGNAAEWRQS SMG1_Mmus KIGPALKTVG--LSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELWSSCTTPDEWWRV smg-1_Cele MIRLAFADHKIDSSITSDRSKWPAEILEEVFESLTAKTPTDLISRELWMRANDATTWWSV SMG1_Ddis KITPLLEKAG--LNFMTPRSEWPKEILIQVLNELMQETPKWILQRELWFSSSSSSELFLK SMG1_Spur -----------------------------------------------------------L AqueK047_Aque KIIPLLNEKG--LNEHTPRKEWPLGIQMRVLKELMNETPRDLLTKELWCASSCASEWWAV SMG1_Smoe KIIPALKEKG--LRKVISRRDWPQDVKRKVLLDLMKETPRQLLYRELWCASDGLKGLNKK SMG1_Hsap TQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGKSLRVPEKVPF CG4549_Dmel VRRFVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNVCFEKGRTLRIPEKVPF SMG1_Mmus TQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGKSLRVPEKVPF smg-1_Cele TKRYSRSLAVMSMVGSVLGLGDRHLDNLLVDLKWGHVVHIDYNICFDKGKNLRIPETVPF SMG1_Ddis TQSYSRSLALMSVIGYMIGLGDRHLDNILLDLKTGEIVHIDYNICFEKGAELKIPERVPF SMG1_Spur TQAFGRSTAVLSMIGYIIGLGDRHLDNVLVNFVTGEVVHIDYNVCFEKGKNLRVPERVPF AqueK047_Aque TQTYCRSTAVMCMIGYIIGLGDRHLDNLLVEFTTGQVVHVDYNVCFEKGKSLRVPERVPF SMG1_Smoe IKRFSGSVAVMSVIGHVLGLGDRHLDNILIDFSSGDVVHIDYNICFEKGRRLKVPEIVPF : : . :::.::* ::*********:*::: *.:**:***:**:** *::** *** SMG1_Hsap RMTQNIETALGVTGVEGVFRLSCEQVLHIMRRGRETLLTLLEAFVYDPLVDWTAGGEAGF CG4549_Dmel RLTQNLVQAMGITGIEGPFRLGCEYVLKVMRKERETLLTLLEAFVYDPLVDWTTNDDAQA SMG1_Mmus RMTQNIETALGVTGVEGVFRLSCEQVLHIMRRGRETLLTLLEAFVYDPLVDWTAGGEAGF smg-1_Cele RLTRNMRHALGPSEMYGTFRESCVHVLSTLRSGHQVLTMLLDAFVFDPLVDWTSHEHTAT SMG1_Ddis RMTQIFEYALGLTGVQGTFRETSIQIMHLLRKNKDILLNLLETFIYDPLFDWKHSNKQTN SMG1_Spur RMTQNVQAALGITGV--------------------------------------------- AqueK047_Aque RMTQNIENALGFTGVEGLFRISCEDILRILRRGRETLLTLLEAFVYDPLIDWTQSEEAAF SMG1_Smoe RLTQTIQNALGPTGVEGFFRASCEAVLSVLQKNKEVILMLLEAFVWDPLVEWMRGDGHDE *:*: . *:* : : SMG1_Hsap AG-----------------AV-YGGGGQQAESKQSKREMEREITRSLFSSRVAEIKVNWF CG4549_Dmel LRRSLNAKLQESADGGGAGGLGVGDLKYHKKDKNKGKPLDSDVKRQPFLSKLGMLQKYWS SMG1_Mmus AG-----------------AV-YGGGGQQAESKQSKREMEREITRSLFSSRVAEIKVNWF smg-1_Cele SGVSL----------ALQLAV-YG-----SNWKTKAKERLTD-AMELLNLRMSEVQTLWL SMG1_Ddis NN-----------------NN--------------------------------------N SMG1_Spur ------------------------------------------------------------ AqueK047_Aque PL-----------------AM-RT--TTELGVRQTRKEMEWEVAEGMLITKLAESEPHWQ SMG1_Smoe A-------------------T-I--------GGEERKGMELAVSLSLFASHVQENRVALQ SMG1_Hsap KNRDEMLVVLPKLDGSLDEYLSLQEQLTDVEKLQGK------LLEEIEFLEGA------- CG4549_Dmel TNKTELMPQLEEMEQEVGNLQAAQAKQVVAEEELVKLNQRSALIAEIKSLGTA------- SMG1_Mmus KNRDEMLVVLPKLDSSLDEYLSLQEQLTDVEKLQGK------LLEEIEFLEGA------- smg-1_Cele ANRDDLLHWMKQVTECL----LIENSM----------------------L-GA------- SMG1_Ddis NN------------------NNNMNQAAGEQESIEK----------------K------- SMG1_Spur ------------------------------------------------------------ AqueK047_Aque KNRENLCSVLLALEKHLNDIALTSEQMVGYQEKIGK------LDKEISILTEA------- SMG1_Smoe EHHDQLLRTLPTIPSTLQSWAAGYENFERCSTLAYH------INQKKYAAENAEVAARNL SMG1_Hsap -------EGVDHPSHTLQHR------YSEHTQLQTQQRAV-QEAIQVKLNEFEQWITHYQ CG4549_Dmel --------IESHSFNTASLRNAVRRGHSEALALLSTERLPDFGRVQCILRSYGQCLQLYH SMG1_Mmus -------EGVDHPSHTLQHR------YSEHTQLQTQQRAV-QEAIQVKLNEFEQWITHYQ smg-1_Cele ------------------------------------------------------------ SMG1_Ddis -------QSSNNSSNPI---------ISTPTKLQQQQKLP-NSPLSISSNN--------- SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ----V--STPNHPLISMQDR------LSEQSRLSAEQKRL-LSLIKEKYDDSLEWNQKYK SMG1_Smoe LAEASGSLEKTHVTYEIQAR------EFAQSKARTAEA----------ARETTQWIEQRS SMG1_Hsap AAFNNLE---------------ATQLASLLQEISTQM----DLGPPSYVPATAFLQNAGQ CG4549_Dmel L--LDLQ----------------GQLVKLQMESNSE-------NAREFSALTEALQLSGL SMG1_Mmus AAFNNLE---------------ATQLASLLQEISTQM----DLGPPSYVPATAFLQNAGQ smg-1_Cele ------------------------------------------------------------ SMG1_Ddis ------------------------------------------------------------ SMG1_Spur ------------------------------------------------------------ AqueK047_Aque SVFTSLH---------------STDKETTLQKLAAMMREPLDLGSSGHEPAVEFLQKTGQ SMG1_Smoe RVLDSLRTDTAPELQALGQRTHSTEAVSLLQAIVAS------------GVALTVLPEPTQ SMG1_Hsap AHLISQCEQLEGEVGALLQQRRSVLRGCLEQLHHYATVALQ--YPKAIFQKHRIEQWKTW CG4549_Dmel DSMRSQLNE-------LLGRMDMVAQKSSKHLQEYAGVMNF--YPEQ---SHR------- SMG1_Mmus AHLISQCEQLEGEVGALLQQRRSVLRGCLEQLHHYATVALQ--YPKAIFQKHRIEQWKAW smg-1_Cele ---------------------------------------------NAIYAQQRVK----- SMG1_Ddis ------------------------------------------------------------ SMG1_Spur ------------------------------------------------------------ AqueK047_Aque AHTVESCDQLEDELVSLLQRRRTVIHGALEALNQYRVITSQ--FPTRYLEQSRSYLWEHC SMG1_Smoe VHF----REVDRDISQFTSARHEALLHARATLQAYA-VALQRLLPGNYYTTSYVHSWAKI SMG1_Hsap MEELICNTTVERCQELYRK----YEMQYAPQPPPTVCQFITATEMTLQRYAADINSRLIR CG4549_Dmel -------------QNLFVR----FHDSFATY--------------IQNGYTADSTTNTNS SMG1_Mmus MEELICNTTVERCQELYRK----YEMQYAPQPPPTVCQFITATEMTLQRYAADINSRLIR smg-1_Cele ------------------------------------------------------------ SMG1_Ddis ------------------------------------------------------------ SMG1_Spur ------------------------------------------------------------ AqueK047_Aque LDEIVNSST-EIHHDQFIKIVESFESLLGPSPPT---RLIMATDNKLRKQIQEQGTKF-Q SMG1_Smoe LQLLSMQVTPEVLGVTKRQ-AID--ITAGGR--GDHDDVICQKHEKLRSHVELLGEEV-Q SMG1_Hsap QVE--RLKQEAVTVPVC----------------------------EDQLKEIERCI---- CG4549_Dmel PSS--SIICKADVVGVA----------------------------EAMEYSWER-L---- SMG1_Mmus QVE--RLKQEAVTVPVC----------------------------EDQLKEIERCI---- smg-1_Cele ------------------------------------------------------------ SMG1_Ddis ------------------------------------------------------------ SMG1_Spur ------------------------------------------------------------ AqueK047_Aque KCD--QLEDELVSLLQRRRTVIHGALEALNQYRVITSQFPTRYLEQSRSYLWEHCLDEIV SMG1_Smoe KLEQGRLQLEESVDPDA----------------------------EKRAK--DKLM---- SMG1_Hsap --------------------------------------KVFLHE--------------NG CG4549_Dmel --------------------------------------GCQLHE--------------AS SMG1_Mmus --------------------------------------KVFLHE--------------NG smg-1_Cele ------------------------------------------------------------ SMG1_Ddis ------------------------------------------------------------ SMG1_Spur ------------------------------------------------------------ AqueK047_Aque NSSTEIHHDQFINIVESFESLLGPSPPTRLIMATDNKLRKQIQE--------------QG SMG1_Smoe --------------------------------------GIFLRSLQQGKKDEDDAGLYDF SMG1_Hsap EEG------------------SL--SLASVIISALCTL------TRRNLMMEGAASSAGE CG4549_Dmel KLYAANQAQALTLGAP-----TT--ALLSMIVQSGCSQLLLKASLVRTLDRAGGAFAAYE SMG1_Mmus EEG------------------SL--SLASVIISALCTL------TRRNLMMEGAASSAGE smg-1_Cele ---------------------------------------------------------AGT SMG1_Ddis ------------------------------------------------------------ SMG1_Spur ------------------------------------------------------------ AqueK047_Aque TKFQKLTERAQALSSIDMKELDLTVKEAHQNLQKFC-------QGKRWLYMEQTARTARD SMG1_Smoe EER------------------RL--KVILVLQSAASTI-----------YSEIGNHAANL SMG1_Hsap QLVDLTSRDGAWFLEELCSMSGNVTCLVQLLKQC-----HLVPQD--LDIPNPMEASETV CG4549_Dmel QVALASHDDG-LLHHQ--------------LLFI-----HLVRTM--LQGVLVMTKEEDQ SMG1_Mmus QLVDLTSRDGAWFLEELCSMSGNVTCLVQLLKQC-----HLVPQD--LDIPNPVEASEAV smg-1_Cele ELREAVTRHH-------------------------------------------------- SMG1_Ddis ------------------------------------------------------------ SMG1_Spur ------------------------------------------------------------ AqueK047_Aque RLSDLTSREGDWFMDELCTMGGNVFQMSSTLETCLSYLGHDIQSD--TLVRSCLD---SV SMG1_Smoe QGVGMEESIRRWCFPELEGLVERAVLVSDVLNELQQ-----FSGKATGYRANPWDSNSSF SMG1_Hsap HLA-NG---VYTSLQELNSNFRQIIFPEALRCLMKGEYTLESML---HELDGLIEQTTDG CG4549_Dmel HLA-Q----------------------------------LESLL---SALSHLKKMFEYD SMG1_Mmus HLA-NG---VYTSLQELNSNFRQIIFPEALRCLMKGECTLESML---HELDSLIEQTTDG smg-1_Cele ------------------------------------------------------------ SMG1_Ddis ------------------------------------------------------------ SMG1_Spur ------------------------------------------------------------ AqueK047_Aque AAV-HS---VYSSMLDLVNKFYSLVMPEVSKSIISDDPSFVQML---DDVADIKLTMFPE SMG1_Smoe TAELKGFTDCLAGIDHLVKQMIGVVLPEAVKAALSQDPAVMDAFASLSQIRGAIDTTLEK SMG1_Hsap VP-------------------LQTLVESLQAYLRNAAMGL-------EEETHAHYIDVAR CG4549_Dmel LP--------------------------------------------------AN---LYR SMG1_Mmus VP-------------------LQTLVESLQAYLRNTAMGL-------EEETHAHYIDVAR smg-1_Cele ----A-------------------LAKELRPLIR--VIGK-------EREEFADYLKFYK SMG1_Ddis ------------------------------------------------------------ SMG1_Spur ------------------------------------------------------------ AqueK047_Aque LP-------------------LPDALRKLIEHLRQCALKNVP----ADLTTTAAVEDLKN SMG1_Smoe VAEIEMQKSALLELERTYPDRLEELVKR-KTFLEEAAAGGKDDLSWEEAEELASQEDLCR SMG1_Hsap LLHAQYGELIQPRNGSV----------------------------DETPKMSAGQMLLVA CG4549_Dmel L------LLLQPNLGKL----------------------------SALCHLSASSLAQLF SMG1_Mmus MLHAQYGELIQPRNGSV----------------------------DETPKMSAGQMLLVA smg-1_Cele ------------------------------------------------------------ SMG1_Ddis ------------------------------------------------------------ SMG1_Spur ------------------------------------------------------------ AqueK047_Aque KLST---IMFSSECEEG----------------------------HDTPSLTQAQVILNG SMG1_Smoe EQLETLQKAWSQRSAQASAVLRMEGLVRSALASADQRFEALVALDRDDLHLMRGKVLLAA SMG1_Hsap FDGMFAQVETAFSLL----VEK---LNKMEIPIAWRKIDIIREARS---TQVNFFDDDNH CG4549_Dmel LEATMEN------------------GHKP------------------------------P SMG1_Mmus FDGMFAQVETAFGLL----VEK---LNKMEIPVAWRKIDIIREARS---TQVNFFDDDNH smg-1_Cele ------------------------------------------------------------ SMG1_Ddis -------------------------------------------TNS---TNNNNNNNNNN SMG1_Spur ------------------------------------------------------------ AqueK047_Aque LNSLFEAVESQTLNM----LDQ---VEEITVPDEWRNTDLVKQTKEVMCTTAGLF----- SMG1_Smoe FAKLFSGLESLDAALRRVPVAKTMQVESPGLEYIWRASNVLQ------------------ SMG1_Hsap RQVLEEIFFLKRLQTIKEFFRLCGTFSKTLSG----SSSLEDQNTVNGPVQIVNVKTLFR CG4549_Dmel DQFPVERRFLLTLQPVYDQFLLASTSLDSLVS--SMQSMLEDVHDVQT-QQIMELG-LM- SMG1_Mmus RQVLEEIFFLKRLQTIKEFFRLCGTFSKTLSG----SSSLEDQNTVNGPVQIVNVKTLFR smg-1_Cele ----------------------QALFDPLLKG----HSALRN------------------ SMG1_Ddis ------------------------------------------------------------ SMG1_Spur ------------------------------------------------------------ AqueK047_Aque --LKEDLLFVRKVSSIVDFCSECKNLMKAFKLELTSDGGGEYLSLVSP-PGTPSKRSSSS SMG1_Smoe ----KKTFFVWKVYVM----------------------------------------DILL SMG1_Hsap NSCFSE----------------------DQMAKPIKAFTADFVRQLLIGLPNQALGLTL- CG4549_Dmel RSCHTELNDECFFGLVSEALESSRTCDVREMARPMLGFIHRLQVEKLAGL----LPILT- SMG1_Mmus NSCFSE----------------------DQMAKPIKAFTADFVRQLLIGLPNQALGLTL- smg-1_Cele ------------------------------------------------------------ SMG1_Ddis ------------------------------------------------------------ SMG1_Spur ------------------------------------------------------------ AqueK047_Aque VPVPTD----------------------QQLSHPIRRYISETLICHVLGQPSYALTCLLV SMG1_Smoe DSCVRD--------------------ASNDLSLSLDQVISQHKRRLEAQL-QGVLDLYL- SMG1_Hsap CSFISALGVDIIAQ-VEAKDFGAESKVSVD-DLCKKAVEHNIQIGKFSQLVMNRATVLAS CG4549_Dmel RNFYTAVGPQCLPT-ASCGD-----PAQAD-HLCESL----------------------- SMG1_Mmus CSFISALGVDIIAQ-VEAKDFGAESKVSVD-DLCKKAVEHNIQVGKFSQLVMNRATVLAS smg-1_Cele ------------------------------------------------------------ SMG1_Ddis ------------------------------------------------------------ SMG1_Spur ------------------------------------------------------------ AqueK047_Aque CTVTQYLEA----P-I---QFGK--PTTIE-EMCKVANEHCQSML--PLGVVQHARTLFS SMG1_Smoe RERVSPAFLDIILKEATISSFADNSDSSREGEAAKKAVKLLRE--------------YCD SMG1_Hsap SYDTAWKKHDLVRRLETSISSCKTSLQRVQLHIAMFQ--------------WQHEDLL-- CG4549_Dmel ---------------FISLQSDGALLQ-QQAEIALLSQQVDLHTLAASAQYWAYSEALGS SMG1_Mmus SYDTAWKKHDLVRRLETSISSCKTSLQRVQLHIAMFQ--------------WQHEDLL-- smg-1_Cele ---------------ELDIDTCVYNFNI-------------------------------- SMG1_Ddis -----------------------------------------------------NNNNN-- SMG1_Spur ------------------------------------------------------------ AqueK047_Aque HHDVAWREWDKARRLTTNLENCKQSIQRLKNITMRFQ--------------WLHEESL-- SMG1_Smoe VHETVRAAKSAAFALKIQADEAKQSLQNAQIEIAQME--------------WLHETVL-- SMG1_Hsap --------INRPQAMSVTPP------------PRSAILTSMKKKLHTLSQIETSIATVQE CG4549_Dmel QLRCGPHIVSRPKLTAA----------------IGECWLELDQKLTALQQLQAGL----- SMG1_Mmus --------ISRPQAMSVTP-------------PRSAILTSMKKKLHALSQIETSIGTVQE smg-1_Cele ------------------------------------------------------------ SMG1_Ddis --------NNNNNNNK-------------------------------------------- SMG1_Spur ------------------------------------------------------------ AqueK047_Aque --------IVPDAVHTWVVQ------------QRSALLTVIKKVLS--EQLATSIGNVIE SMG1_Smoe --------LPRVQFVAMPSGPYPEKSTSIRWWSRKQILDNIRNSIAAISRATEGLQKAER SMG1_Hsap KLAALESSIEQRLKWAGGANPALAPVLQDFEATIAERRNLVLKESQRASQVTFLCSNIIH CG4549_Dmel -----ESQLSQ-------------------------------LQTQRSNWNRNHIDNLLR SMG1_Mmus KLAALEASIEQRLKWAGGANPALAPVLQDFEATIAERRNLVLKESQRANQVTFLCSNIIH smg-1_Cele ------------------------------------------------------------ SMG1_Ddis ------------------------------------------------------------ SMG1_Spur ------------------------------------------------------------ AqueK047_Aque KIHSQQFRISQRLQWAAGANSSLNKVIDEFQRACNHHKTMLEREESIFIEMEEMAKAIIH SMG1_Smoe ASVSAEEQLERTMAWASNR----AGTSQEFRERLQRRQQLLWTGQEHATSTVRLCVTVLE SMG1_Hsap FESLRTRTAEALNLDAALFELIKRCQQMCSFASQFNSSVSELELRLLQRVDTGLEHPIG- CG4549_Dmel MEQCNK-----------------------------------------QR----------- SMG1_Mmus FESLRTRTAEALSLDAALFELIKRCQQMCSFASQFNSSVSELELRLLQRVDTTLEHPIG- smg-1_Cele ------------------------------------------------------------ SMG1_Ddis ------------------------------------------------------------ SMG1_Spur ------------------------------------------------------------ AqueK047_Aque LESSHTRIPAQTSSDRETIQILQRCSDVTVKLKLCGE-----ELTQLSDIMPHLQLPSDG SMG1_Smoe FEASREGYLESSSSSSSS--------DGKSWQQSYQSLILRLEAAYIAF-------TSC- SMG1_Hsap ---SSEWLLSAHKQLTQDM-------STQRAIQTEKEQQIETVCETIQ---NLVDNIKTV CG4549_Dmel --------TMSHVALLQKM-------TDGAGAVARLEQNAIVVGEEGQ---ALVDHLEQW SMG1_Mmus ---SSEWLLSAHKQLTQDM-------STQRAVQTEKEQQIETVCETIQ---SLVDSVKTV smg-1_Cele ------------------------------------------VMQNIDNVF--------- SMG1_Ddis ---------------DQD---------S-------------------------------- SMG1_Spur ------------------------------------------------------------ AqueK047_Aque SPLNKEWI---QKRLDEAT-------SERTKLQGDKKFSNNKVVKNKENVLSELEKLRSL SMG1_Smoe ---DMEWK-AAQKALEAASANLSGVLRERQLVSSESESSGDHCAAE-------------- SMG1_Hsap LTGHNRQLG----------------------------DVKHLLKAMA--KDEEAALADGE CG4549_Dmel LAAHGQWQASSSRISAVEQSMVELLDPEGAIDHYWLENVQGLLEEQTCKVHREIAAIEGE SMG1_Mmus LTGHNRQLG----------------------------DVKHLLKAMA--KDEEAALADAE smg-1_Cele ------------------------------------------------------------ SMG1_Ddis ------------------------------------------------------------ SMG1_Spur ------------------------------------------------------------ AqueK047_Aque NRQHRKLLV----------------------------EVWQQLTSLA--KLEDPPAA-GQ SMG1_Smoe ------------------------------------------------------------ SMG1_Hsap DVP----YENSVRQFLGEYKSWQDNIQTV----LFTLVQ--AMGQVRSQEHVEMLQEITP CG4549_Dmel QQS----KHRFICTLLKETLRLLENMPRFHVQSLCSEAQ--AQGQGKM--EYANVQLLSD SMG1_Mmus DIP----YESSVRQFLAEYKSWQDNIQTV----LFTLVQ--AMGQVRSQEHVEMLQEITP smg-1_Cele ------------------------------------------------------------ SMG1_Ddis ------------------------------------------------------------ SMG1_Spur ------------------------------------------------------------ AqueK047_Aque LQPGPRAFINHQNRFGEETKSFIQSTQDL----IASDMSLTSKPSWTSKARAEEFRQLGT SMG1_Smoe ------------------------------------------------------LQSIFL SMG1_Hsap TLKELKTQSQSIYNNLVSFASPLVTDATNEC-------SSPTSSAT-YQPSFAAAVRSN- CG4549_Dmel HLREGQGLMQSLYMRLQELRKDICSDRR-----------------V-LQPSMLQNWRHQL SMG1_Mmus TLKELKTQSQSIYNNLVSFASPLVTDAANEC-------SSPTSSAT-YQPSFAAAVRSN- smg-1_Cele -------------GAL-------------------------------------------- SMG1_Ddis -----------------------------------------DSSQS-QEDEDNNVVEGE- SMG1_Spur ------------------------------------------------------------ AqueK047_Aque MAVNLRGLAEWILGQLLSFTEQLFINPYSSKLKWHEPLQLESSSISLKNRSSSLSVASQ- SMG1_Smoe QLRQLTLEAAG------------------------------------AVNAFCKVVRSH- SMG1_Hsap ------------TGQKTQPDVMSQNARKLIQKNLATSADTPPSTVPGTGKSVACSPKKAV CG4549_Dmel EMILTLAKQEVNEFFKGLEDFMQHA--------GETDSYEIFTHAKGS------------ SMG1_Mmus ------------TGQKTQPDVMSQNAKKLIQKNLATSADTPPSTIPGTGKSIACSPKKAV smg-1_Cele ----VNL------------------------------SFTPIETITSRTSQQEFKPPPGL SMG1_Ddis ------------GGEGGEGD---------------------------------IDELNLV SMG1_Spur ------------------------------------------------------------ AqueK047_Aque ------------SGQQ---DSEQQS-------------------------RIYRSSQGIV SMG1_Smoe ------------SALTSEGAVMLDEARADGVSDVHSL----------------------- SMG1_Hsap RDPKTGKAVQERNSYAVSVWKRVKA------------------KLEGR---DVDPNRRMS CG4549_Dmel ----GNVHEQKRNAYGVSVWKKIRM------------------KLEGR---DPDSNQRST SMG1_Mmus RDPKTGKAVQERNSYAVSVWKRVKA------------------KLEGR---DVDPNRRMS smg-1_Cele ENVWVVKQDQQENSQAREVVRRVER------------------RLNGWLDGSAGPDRKLS SMG1_Ddis QDSSNGK-DAFKSIQGLTVVNQVRL------------------KLEGT-------EKKLS SMG1_Spur ------------------------------------------------------------ AqueK047_Aque RDLRTGKALQEQNSYAVSVWRRVKG------------------KLDGR---DPDPACRMT SMG1_Smoe ----AKEAITERQSL-ISDLKKVHAAVAPLELLLSSTANAMSADLDVK---AVIKSGQSP SMG1_Hsap VAEQVDYVIKEATN---------L------------------DNLAQLYEGWTAWV CG4549_Dmel VAEQVDYVIREACN---------P------------------ENLAVLYEGWTPWV SMG1_Mmus VAEQVDYVIKEATN---------L------------------DNLAQLYEGWTAWV smg-1_Cele PREEADILIAEATS---------T------------------PNLSQMYEGWTAWV SMG1_Ddis IPDQIDLIIRESMN---------V------------------ENLSSTYEGWSPWV SMG1_Spur -------------------------------------------------------E AqueK047_Aque VAEQVKFVIDEATS---------P------------------ENLCQLYEGWTPWV SMG1_Smoe TLQSLDLKIKESLADLPLHVSSVLDAAQKLHSALTSLGRTASVDAGTLNKASPNVS