CLUSTAL W (1.83) multiple sequence alignment SNRK_Hsap MAG-----------FKRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDK CG8485_Dmel MTLET-------QPVGGVSDGKIAGLYDLEETLGSGHFAVVKLARHVFTGAKVAVKVVDK SNRK_Mmus MAG-----------FKRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDK ZK524.4_Cele MSNAPETGALRRKSSLHIRDTRIAGLYDLEKTIGQGHFAVVKLAKHVFTGEMVAVKIIDK SNRK_Spur MSGS---------FFKHNHDPKIVGSYDLEETLGRGHFAIVKLARHIFTGEKVAVKVIDK AqueK070_Aque MA------------------SKIAGLYDMEDTLGSGHFAVVKSARHVFTGLRVAVKVIDK *: :*.* **::.*:* ****:** *:*:*** ****::** SNRK_Hsap TKLDTLATGHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEE CG8485_Dmel TKLDDVSKAHLFQEVRCMKLVQHPNVVRLYEVIDTQTKLYLVLELGDGGDLYDYIMKHDS SNRK_Mmus TKLDTLATGHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEE ZK524.4_Cele TKMDEASTSQIMKEVRCMKLVQHANIVRLYEVLDTQTKIFLILELGDY-DLHDFIIKHEK SNRK_Spur LKLDAVSKAHLFQEVKCMKLVQHPNVVRLYEVIDTQTKLYLILELGDGGDMYDYIMKHEN AqueK070_Aque TKLDDVSKTHLYQEVRCMKLVSHPCIIRLYEVIDTQTKLYLIEELGDGGDLYDFIMKHPN *:* :. :: :**:*****.*. ::*****:*****::*: **** *:.*:*:** . SNRK_Hsap GLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQ---GLVKLTDFGFSNKFQ CG8485_Dmel GLSEELARKYFRQILRAITYCHQLHVVHRDLKPENVVFFEKL---GLVKLTDFGFSNKFL SNRK_Mmus GLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQ---GLVKLTDFGFSNKFQ ZK524.4_Cele GVCESLAQQYFCQIMTAIDYCHQLHVVHRDLKPENVVFFEKL---GMVKLTDFGFSNSYE SNRK_Spur GLDDDIARTYFRQIVEAISYCHKRRVVHRDLKPENVIFFKKQ---GVVKLTDFGFSNRFM AqueK070_Aque GVNEDLGRCIFRQTVSAIQYCHQLHVVHRDLKPENLVFCQTASNNVCIKLTDFGLSRTFM *: :.:.: * * : ** ***: :**********::* :. :******:*. : SNRK_Hsap PGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTM CG8485_Dmel PGQKLETFCGSLAYSAPEILLGDSYDAPAVDIWSLGVILYMLVCGQAPFEKANDSETLTM SNRK_Mmus PGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTM ZK524.4_Cele PGEQLNTSCGSLAYSAPEILLGDSYDAPAVDVWSLGVILYMLVCGRLPFQEANDSETLTK SNRK_Spur PGEKLETSCGSLAYSAPEILLGDSYDAPAVG----------------------------- AqueK070_Aque PGEMIESSCGSLEYSAPEILLGDFYDPPKVDVWSLGVILFMLICGHSPFVSGGASETLTH **: : : **** ********** **.* *. SNRK_Hsap IMDCKYTVPSHVSKECKDLITRMLQRDPKRRASLEEIENHPWLQGVDPSPAT----KYNI CG8485_Dmel IMDCKYTVPSHVSTDCRDLIASMLVRDPKKRATVEEIASSAWLKPIDEPDSTTSTSEHFL SNRK_Mmus IMDCKYTVPPRVSAGCRDLITRMLQRDPKRRASLEEIESHPWLQGVDPSPAT----KYNI ZK524.4_Cele ILDCKYSIPDVLSDECRNLIQSMLVREPQKRASLEKIVSTSWVQAGDRGLST------AI SNRK_Spur ------------------------------------------------------------ AqueK070_Aque IMDGRYEIPAHVSESCRDLIRRMLVVDAIQRCSLNDVVTHPWLNEGSVVDPL------TL SNRK_Hsap PLVSYKNLSEEEHNSIIQRMVLGDIADRDAIVEALETNRYNHITATYFLLAERILREKQE CG8485_Dmel PLVSREQLGEEDHAFIIQKMINGNIASKEEILQALDKNKYNHITATYFLLAELRLRRRRE SNRK_Mmus PLVSYKNLSEEEHNSIIQRMVLGDIADRDAIVEALETNRYNHITATYFLLAERILREKQE ZK524.4_Cele PLIVRHHLPTSAHATIIEQMVAGAIASEEDILRFLENDEYNSVTATYYLLAERVLASYRE SNRK_Spur ------------------------------------------------------------ AqueK070_Aque PSINLPDIPSEEVHYILERMEAGGYGSTESILESVQDKPYGSVAATFYLLAEAERHRKLH SNRK_Hsap KEIQT---R----------------SASPSNIKAQFR--------QSWPTKI-D-VPQDL CG8485_Dmel ELAQK---QR---------------LLNDASMKVG------------------------- SNRK_Mmus KEIQT---R----------------SASPSNIKAQFR--------QSWPTKI-D-VPQDL ZK524.4_Cele EQARELLAKHVEWDDRPDPISDNSGATTRSNINSRCRSR----S-NSWRARPCSILKEES SNRK_Spur ------------------------------------------------------------ AqueK070_Aque VQSPQ---H----------------VVAPCQISASVLGGAGGGETANTSRKI-S-VPT-- SNRK_Hsap EDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELA--GPALSTVPPA- CG8485_Dmel -------DASRKLVPEKPSPTE---------------AQKGG-------VPISINVTPAA SNRK_Mmus EDDLTATPLSHATVPQSPARAGDNVLNGHRSKGLCDPAKKDELPELA--GPALSTVPPA- ZK524.4_Cele EEELSS-YLRSASRQSSRFYPLHDFVSSPRSASRCCSAQLSRQNSEE--AMSLKSLDSDS SNRK_Spur ------------------------------------------------------------ AqueK070_Aque -----QPPLNN-ILKLNPA-GGSYKSHGHAETGVLLPRRRT-TPEEPVTSKARSSSSPTH SNRK_Hsap ----------------------SLKPTASGRKCLFRVEED-------------------- CG8485_Dmel Q-----------------FANDGGKPDKRSRKCSIVREED-------------------- SNRK_Mmus ----------------------SMKPAASGRKCLFRVEED-------------------- ZK524.4_Cele MRPTT---FYIPNSAVSTTNPTTPTSAIINRFDEVLSPID-------------------- SNRK_Spur ------------------------------------------------------------ AqueK070_Aque LTKSPYQNPNYTSPRLGV-GG-EQVSNTNTRKPLFPIQSVAEDSTGLSETDSQSTLDLPP SNRK_Hsap -----------EEEDEE-D---------------------------------------KK CG8485_Dmel -----------EEESAT-E---------------------------------------CT SNRK_Mmus -----------EEEDEE-D---------------------------------------KK ZK524.4_Cele -----------EREGSESDLVRKNLRKIVLNEIVDDSLAGSDEHAIRKSSDSCLHAHHQL SNRK_Spur ------------------------------------------------------------ AqueK070_Aque PPPRMRHLSACEEEGES-D---------------------------------------EV SNRK_Hsap PM-SLSTQVVLRRKPSVTNRLT-----------------------------SRKSAPVLN CG8485_Dmel AV-GNE------LKVTSSSRRE-----------------------------AFSDSPFSR SNRK_Mmus PV-SLSTQVVLRRKPSVTNRLT-----------------------------SRKSAPVLN ZK524.4_Cele LR-SASAKRLLRRNSSPSVSMFSGITRDRVSPQAVQELLDLNRLGGVRGRAASPESV--R SNRK_Spur ------------------------------------------------------------ AqueK070_Aque IVDGMRSQSPLPS--PRSRRLL-----------------------------SARSSPNLA SNRK_Hsap QIFEEGESDD-------------------------------------------------E CG8485_Dmel SIHERSSSEPGNQTKGEQIANSGVPSHSRTKIVVS-VDATLAHKLKQ-------MEKSAK SNRK_Mmus QIFEEGESDD-------------------------------------------------E ZK524.4_Cele --SSRSPSPPASSSGRTSPAMSTISSMSRLKVSASNVTNSGMRKLSSSPHLLGICEETED SNRK_Spur ------------------------------------------------------------ AqueK070_Aque KSVSRS-----------------------------------------------DFSDEED SNRK_Hsap FD------MD----E-------------------NLP-------------------P--- CG8485_Dmel IDEDTLSGLK----E-------------------LEI-------------------G--- SNRK_Mmus FD------MD----E-------------------NLP-------------------P--- ZK524.4_Cele GSEVLQSTSSRHLRTLDDRGGRANRYRSASTGLVHLPSRHHSVHATKSSAASLLTTPFVS SNRK_Spur ------------------------------------------------------------ AqueK070_Aque DDDIMD---L----S-------------------TVP-------------------R--- SNRK_Hsap ---KLS-------------------------RLKMNIASPG-----TVHKRYHRRKSQGR CG8485_Dmel ---KLK-------------------------PLPSSSKNPV-----LTHRRTKL--NKIR SNRK_Mmus ---KLS-------------------------RLKMNIASPG-----TVHKRYHRRKSQGR ZK524.4_Cele KPQGITPTPSSSSSTSFVQFTPNTYSAVRSIRPRQAIVSPDILRRYDPHQRFIV--RSKR SNRK_Spur ------------------------------------------------------------ AqueK070_Aque ---SHP-------------------------THPSPLASPH-----LSYSRLSPTHSQGY SNRK_Hsap GSSCSSSETSDDDSESRRR--LDK---DSGFTYSWH---RRDSSE----------GPPGS CG8485_Dmel TPSCSSSEASDDDTKTRNKKKINKFVGDTPVRFRMH---RRDSHDDSSDSQDQLYPPPGS SNRK_Mmus GSSCSSSETSDDDSESRRR--LDK---DSGFAYSWH---RRDSSE----------GPPGS ZK524.4_Cele STSCSSSDASDDDDGRRL-TM---LS--SKCASKFD---EKNKKDDD------------D SNRK_Spur ------------------------------------------------------------ AqueK070_Aque SSDEESLSHTLLYDGRRKR--SSK---RIRYNKALHPLVRVDSAS----------SDDGS SNRK_Hsap EGDGGGQ-SKP-SNASG----------------------------------GVDKASPSE CG8485_Dmel ASNAGNFISKS-GSVSG-KKEGQSQYKEPNNKSDENRKSHSQKNRKQHNKDHVDKHSHAE SNRK_Mmus EGDGGGQ-SKP-SS-GG----------------------------------GVDKASPGE ZK524.4_Cele EANGGTT-GKRGNSGSG-TTSLTVTGKQSNNQSGIAPQSNE--KRSTLNDSVLPLRPIPE SNRK_Spur ------------------------------------------------------------ AqueK070_Aque FNDKHLRHSLP-KFGKDKLRKMLP---Y--------------------------RSTPST SNRK_Hsap NNAGGGSPS-----------SGSGGNPTNTSGT------------------TRRCAGPSN CG8485_Dmel RQLADSS-T------------ATTGNSTNRRRRIRESQSLDRITEAQEYEMRHRCYAESE SNRK_Mmus QGTGGGSQ------------GGSGGTPSGTAGS------------------SRRCAGPDS ZK524.4_Cele MTLLDQT-L------------TSPDCASIRDRILHTSL--STQTMIRKWTE--------- SNRK_Spur ------------------------------------------------------------ AqueK070_Aque PAEGSGSESFTDMLAVRMRSSSGGGRPRCNSAR------------------TD------S SNRK_Hsap SM-QLASRS----AGELVESLKLMSLCLGSQLHGSTKYIIDPQNGLSFSSVKVQEKSTWK CG8485_Dmel AA-SSSSSS----TQHIDQRYSLLSLNT-----------------STFSVAETKEEY--- SNRK_Mmus SSPSPASASAAPRGAELVQSLKLVSLCLGSQLHG-AKYILDPQKAL-FSSVKVQEKSTWK ZK524.4_Cele -----------------------M----------DSWYG-TPPRDY-EDRTHLHEKTPWL SNRK_Spur ------------------------------------------------------------ AqueK070_Aque SL-SD--------------------TN-----------------ELSFQIHERL------ SNRK_Hsap MCISSTGNAGQVPAVGGIKFFSDHMADTTTELERIK-SKNLKNNVLQL---PLCEKTISV CG8485_Dmel ----------------DEEADATNATDQ------IMNTLNAAKATLQQEQYFNNNTNLSR SNRK_Mmus MCISAPGPSP------------------SADLDPVR-TKKLRNNALQL---PLCEKTISV ZK524.4_Cele RCLRRTASSQDLLRESDEKATSEHGNDS-------------------------------- SNRK_Spur ------------------------------------------------------------ AqueK070_Aque ------------------------------------------------------------ SNRK_Hsap NIQRNPKEGLLCA----------------------------------------------- CG8485_Dmel NFNHNHNQSIIHISSQKANGKKSNETPKDIYNLNSIEHIDLILEDKSLTKAIHVTGSKCF SNRK_Mmus NIQRSRKEGLLCA----------------------------------------------- ZK524.4_Cele GCSTTEKDGEHQC-----------TSPQ------------------FIQQNMYNDSKFSF SNRK_Spur ------------------------------------------------------------ AqueK070_Aque --ELSDGEEL-------------------------------------------------- SNRK_Hsap ---------SSPASCC-HVI CG8485_Dmel VTMKKIRRLGKYFPVM-NFS SNRK_Mmus ---------SSPASCC-HVI ZK524.4_Cele LNTLPMEKVDRWLQCADFVF SNRK_Spur ------------------RK AqueK070_Aque ---------DKPDEPV-SDD