CLUSTAL W (1.83) multiple sequence alignment TGFbR1_Hsap MEAAVAAPRPRLLLLVLAAAA--------------------------------------- BMPR1B_Mmus MLLRSSGK--L---NVGTK----------------------------------------- BMPR1A_Mmus MTQLYTYIRLLGACLFIISHV--------------------------------------- ALK7_Mmus MTPARGSALS-LALLLVALAA--------------------------------------- ALK4_Mmus MAESAGASSFFPLVVLLLAG---------------------------------------- ALK2_Mmus MVDGVMILPV-LMM-MAFPSPSVE------------------------------------ ALK1_Mmus MTLGSFRRGL-LMLSVAFGLTRGD------------------------------------ daf-1_Cele MRIRHVVFCL--LA-LVYGAETSD------------------------------------ BMPR1A_Hsap MPQLYIYIRLLGAYLFIISRV--------------------------------------- BMPR1B_Hsap MLLRSAGK--L---NVGTK----------------------------------------- ALK7_Hsap MTRALCSALR-QALLLLAAAA--------------------------------------- ALK4_Hsap MAESAGASSFFPLVVLLLAG---------------------------------------- tkv_Dmel MGSEFSANVQPDVEAMAAAAL--------------------------------------- SAX_Dmel MESNIYLVFL-LTF-LLYNNARAE-----------I-----------------------S BABO_Dmel MLSALRLI---FLGALLGASVCAS-----------PIEFVMDTSLNGSRSDPATATHPGK TGFBR1_Mmus MEAAAAAPRRPQLLIVLVAAA--------------------------------------- sma-6_Cele MNITFIFI---LIFGFFNTQKCSKDYDHFDDEDLAL------------------------ ALK2_Hsap MVDGVMILPV-LIM-IALPSPSME------------------------------------ ALK1_Hsap MTLGSPRKGL-LMLLMAL-VTQGD------------------------------------ TGFbR1_Spur MEII-------------------------------------------------------- ALK2_Spur MRASQDVY----VADL--A----H------------------------------------ BMPR1_Spur MSYTYMRYYEVLA----------------------------------------------- AqueK680_Aque LPFITSE-------ITSATH-SHT------------------------------------ AqueK681_Aque MIILILI-------LFLLSP---------------------------------------- AqueK682_Aque M----------------------------------------------------------- : TGFbR1_Hsap ------------------------------------------------------------ BMPR1B_Mmus ------------------------------------------------------------ BMPR1A_Mmus ------------------------------------------------------------ ALK7_Mmus ------------------------------------------------------------ ALK4_Mmus ------------------------------------------------------------ ALK2_Mmus ------------------------------------------------------------ ALK1_Mmus ------------------------------------------------------------ daf-1_Cele ------------------------------------------------------------ BMPR1A_Hsap ------------------------------------------------------------ BMPR1B_Hsap ------------------------------------------------------------ ALK7_Hsap ------------------------------------------------------------ ALK4_Hsap ------------------------------------------------------------ tkv_Dmel ------------------------------------------------------------ SAX_Dmel DHLREDIPDLDMELSSAS------SAHL--------NGK------ELPA--V------P- BABO_Dmel WPPTTKAPALRAPAGTAGHAYQSPSSSLAADNRSHDNNNASAVSMLLPQDGDASGAVAPA TGFBR1_Mmus ------------------------------------------------------------ sma-6_Cele ------------------------------------------------------------ ALK2_Hsap ------------------------------------------------------------ ALK1_Hsap ------------------------------------------------------------ TGFbR1_Spur ------------------------------------------------------------ ALK2_Spur ------------------------------------------------------------ BMPR1_Spur ------------------------------------------------------------ AqueK680_Aque ------------------------------------------------------------ AqueK681_Aque ------------------------------------------------------------ AqueK682_Aque ------------------------------------------------------------ TGFbR1_Hsap ---------A-------------------------------------------------- BMPR1B_Mmus --------------------------------K----------------ED--------- BMPR1A_Mmus ---------Q-GQNLDSMLHGTGMKSDLDQKKP----------------EN--------- ALK7_Mmus ------------------------------------------------------------ ALK4_Mmus ---------S-------------------------------------------------- ALK2_Mmus ------------------------------------------------------------ ALK1_Mmus ------------------------------------------------------------ daf-1_Cele ---------DDL--------------------D----------------ERTNIFIRDKL BMPR1A_Hsap ---------Q-GQNLDSMLHGTGMKSDSDQKKS----------------EN--------- BMPR1B_Hsap --------------------------------K----------------ED--------- ALK7_Hsap ------------------------------------------------------------ ALK4_Hsap ---------S-------------------------------------------------- tkv_Dmel ---------S-G-----MEMGSGPGS-EGYE-D----------------AD--------- SAX_Dmel ------------------------------------------------------------ BABO_Dmel VTPQLPIYIA-------------------------------------------------- TGFBR1_Mmus ------------------------------------------------------------ sma-6_Cele ---------SI---------------------PKNAIGVPKEFRQQVLKEM--------- ALK2_Hsap ------------------------------------------------------------ ALK1_Hsap ------------------------------------------------------------ TGFbR1_Spur ------------------------------------------------------------ ALK2_Spur ------------------------------------------------------------ BMPR1_Spur ------------------------------------------------------------ AqueK680_Aque --------------------------------------------------R--------- AqueK681_Aque ------------------------------------------------------------ AqueK682_Aque ------------------------------------------------------------ TGFbR1_Hsap ------AAAALLPGATALQCF------CHL----CT-------------------KDNFT BMPR1B_Mmus -----GESTAPTPRPKILRCK------CHH-H--CPE-----------------DSVNNI BMPR1A_Mmus -----GVTLAPEDTLPFLKCY------CSG-H--CPD-----------------DAINNT ALK7_Mmus -------D--LA---AGLKCV------CLL----CD-------------------SSNFT ALK4_Mmus ------GG-SGPRGIQALLCA------CTS----CL-------------------QTNYT ALK2_Mmus -------DEKPKVNQKLYMCV------CEG-L--S------------------CGN-EDH ALK1_Mmus -------LAKP---SKLVNCT------CES-P--H------------------CKR--PF daf-1_Cele IPALKLAEVTKVNFTRLHLCH------CSR-EVGCNARTTGWVPGIEFLNETDRSFYENT BMPR1A_Hsap -----GVTLAPEDTLPFLKCY------CSG-H--CPD-----------------DAINNT BMPR1B_Hsap -----GESTAPTPRPKVLRCK------CHH-H--CPE-----------------DSVNNI ALK7_Hsap -------E--LS---PGLKCV------CLL----CD-------------------SSNFT ALK4_Hsap ------GG-SGPRGVQALLCA------CTS----CL-------------------QANYT tkv_Dmel -----NEKSKTVENARSLTCY------CDG-S--CPD-----------------NVSNGT SAX_Dmel -------QNSVQ-THPRYKCY-----SCEP-P--CRD----------------PYEFTHT BABO_Dmel ------QPSAKKP-ENKIKCH------CDT----CK-------------------ESNNI TGFBR1_Mmus ---------TLLPGAKALQCF------CHL----CT-------------------KDNFT sma-6_Cele -----KLRNRPN-DILKNRCY------CNY-D--QSI----------------C-GNNMT ALK2_Hsap -------DEKPKVNPKLYMCV------CEG-L--S------------------CGN-EDH ALK1_Hsap -------PVKPSR-GPLVTCT------CES-P--H------------------CKG--PT TGFbR1_Spur ------------------------------------------------------------ ALK2_Spur -------Q--VN-NSVTLQCN------CDD-Y--S------------------CEG-TNR BMPR1_Spur --------------TKMLYCY------CDE-H--CPE-----------------ITRNNT AqueK680_Aque -----S-L--PLPPLPNNNIYTHPLTSAKTPS--CDI-----------------YAFLHT AqueK681_Aque -------L--IISGTTGVQCF------ETQDG--CSL-----------------T--AGV AqueK682_Aque ------------------------------------------------------------ TGFbR1_Hsap CVT--DGLCFVSVTETT-------DKV-----IHNSMCIAEIDLI-----PR--DRPFVC BMPR1B_Mmus CST--DGYCFTMIEEDD------SGMP-----VVTSGCLGLE------------GSDFQC BMPR1A_Mmus CIT--NGHCFAIIEEDD------QGET-----TLTSGCMKYE------------GSDFQC ALK7_Mmus CQT--EGACWASVMLTN-------GKE-----QVIKSCVSLPEL----------NAQVFC ALK4_Mmus CET--DGACMVSIFNLD-------GVE-----HHVRTCIPKVELV-----PA--GKPFYC ALK2_Mmus CEG---QQCFSSLSIN-------DGF-----HVYQKGCFQVYE-----------QGKMTC ALK1_Mmus CQG---SWCTVVLVRE-------QGRH----PQVYRGCGSLNQ--------------ELC daf-1_Cele CYT--DGSCYQSARPS-------P--E-----ISHFGCMDEKSVTDETEFHD--TAAKVC BMPR1A_Hsap CIT--NGHCFAIIEEDD------QGET-----TLASGCMKYE------------GSDFQC BMPR1B_Hsap CST--DGYCFTMIEEDD------SGLP-----VVTSGCLGLE------------GSDFQC ALK7_Hsap CQT--EGACWASVMLTN-------GKE-----QVIKSCVSLPEL----------NAQVFC ALK4_Hsap CET--DGACMVSIFNLD-------GME-----HHVRTCIPKVELV-----PA--GKPFYC tkv_Dmel CETRPGGSCFSAVQQLY------DETTGMYEEERTYGCMPPEDN----------GGFLMC SAX_Dmel CQN--AIQCWKSRTRDA------DGQ-----VQESRGCSTSPD-----------QLPMIC BABO_Dmel CET--DGFCFTSVEKNS------DGSI-----IFSYSCMVVKYNM-----QR--SKPFEC TGFBR1_Mmus CET--DGLCFVSVTETT-------DKV-----IHNSMCIAEIDLI-----PR--DRPFVC sma-6_Cele CVKQDGAACYHAVEEVY------NKAEKRMETLHKWGCATLERGS------G--ASHLTC ALK2_Hsap CEG---QQCFSSLSIN-------DGF-----HVYQKGCFQVYE-----------QGKMTC ALK1_Hsap CRG---AWCTVVLVRE-------EGRH----PQEHRGCGNLHR--------------ELC TGFbR1_Spur ------------------------------------------------------------ ALK2_Spur CEA--LRKCFSSITEV-------DGI-----IMKRMGCVNTEE-----------QFNMFC BMPR1_Spur CYPSPGGWCFAQIQAGE------DGVEH-ETPIRSYGCLAPEED----------GGLMQC AqueK680_Aque CIS--AIERWTSRGRSA------DGY-----SRRGRGCSTCKLTV-----SWSQQNKE-- AqueK681_Aque CNA--ST-CYMRILAKANPRNISEHQ-----FSYIYGCLPEEEGG-----NGPSVIASLC AqueK682_Aque ------------------------------------------------------------ TGFbR1_Hsap AP-SS---------KTG-SVTTTYCCN-QDHCNKIEL--PTT------------------ BMPR1B_Mmus RD-TP---------IPH-QRRSIECCTERNECNKDLH--PTL------------------ BMPR1A_Mmus KD-SP---------KAQ-LRRTIECCR-TNLCNQYLQ--PTL------------------ ALK7_Mmus HS-SN-------------NVTKTECCF-TDFCNNITLHLPTA------------------ ALK4_Mmus LS-SE-------------DLRNTHCCY-IDFCNKIDLRVPSG------------------ ALK2_Mmus KT-PP-----------S-PGQAVECCQ-GDWCNRNIT--AQL------------------ ALK1_Mmus LG-RP-----------T-EFLNHHCCY-RSFCNHNVS--LML------------------ daf-1_Cele TN-NT---------KDPH-ATVWICCDKGNFCANETI--IHL------------------ BMPR1A_Hsap KD-SP---------KAQ-LRRTIECCR-TNLCNQYLQ--PTL------------------ BMPR1B_Hsap RD-TP---------IPH-QRRSIECCTERNECNKDLH--PTL------------------ ALK7_Hsap HS-SN-------------NVTKTECCF-TDFCNNITLHLPTA------------------ ALK4_Hsap LS-SE-------------DLRNTHCCY-TDYCNRIDLRVPSG------------------ tkv_Dmel KV-AA---------VPHLHGKNIVCCDKEDFCNRDLY--PTY------------------ SAX_Dmel SQ-NSLKINGPSKRNTG-KFVNVVCCA-GDYCNEGDF--PEL------------------ BABO_Dmel LT-SN---------ERF-DTYRIDCCK-SDFCNKNEIMK-RI------------------ TGFBR1_Mmus AP-SS---------KTG-AVTTTYCCN-QDHCNKIEL--PTT------------------ sma-6_Cele NS-WR---------AAHHSPKSIGCCYEGNYCNKNLI--PPA------------------ ALK2_Hsap KT-PP-----------S-PGQAVECCQ-GDWCNRNIT--AQL------------------ ALK1_Hsap RG-RP-----------T-EFVNHYCCD-SHLCNHNVS--LVL------------------ TGFbR1_Spur ------------------------------------------------------------ ALK2_Spur KM-HP-----------Y-PDISVLCCN-RSFCNNDLQ--PTF------------------ BMPR1_Spur KG-QL---------SNHRISRTVYCCNDEPNCNLKLN--PTL------------------ AqueK680_Aque -SPSE---------QPVNKVMHFFCCD-DDYCNQDIM--HSI------------------ AqueK681_Aque SGPAS---------WDRELLISYTCCT-SDHCNKNIE--PRHDIESLLINRYNNDSNDQE AqueK682_Aque ------------------------------------------------------------ TGFbR1_Hsap --------------------------------------------------------VK-- BMPR1B_Mmus --------------------------------------------------------PPL- BMPR1A_Mmus --------------------------------------------------------PPV- ALK7_Mmus --------------------------------------------------------S--- ALK4_Mmus --------------------------------------------------------HL-- ALK2_Mmus ---------------------------------------------------------PT- ALK1_Mmus ---------------------------------------------------------EA- daf-1_Cele --------------------------------------------------------APG- BMPR1A_Hsap --------------------------------------------------------PPV- BMPR1B_Hsap --------------------------------------------------------PPL- ALK7_Hsap --------------------------------------------------------S--- ALK4_Hsap --------------------------------------------------------HL-- tkv_Dmel --------------------------------------------------------TPK- SAX_Dmel --------------------------------------------------------LPF- BABO_Dmel ---------------------------------------------------------F-- TGFBR1_Mmus --------------------------------------------------------GPF- sma-6_Cele --------------------------------------------------------YVHH ALK2_Hsap ---------------------------------------------------------PT- ALK1_Hsap ---------------------------------------------------------EA- TGFbR1_Spur ------------------------------------------------------------ ALK2_Spur --------------------------------------------------------LPT- BMPR1_Spur --------------------------------------------------------PPT- AqueK680_Aque --------------------------------------------------------LES- AqueK681_Aque SSSVFVSSSVPSSSSVPILPSVPILLSVPISPSVPISPSVPISFSSSYQYLYDLTSLPT- AqueK682_Aque ------------------------------------------------------------ TGFbR1_Hsap -------------S--------------------------------------------SP BMPR1B_Mmus ----------KDRDF--------------------------------------------- BMPR1A_Mmus ----------VIGPF--------------------------------------------- ALK7_Mmus ------------PN--------------------------------------------AP ALK4_Mmus ----------KEPA--------------------------------------------HP ALK2_Mmus ----------KGKSF----------------P---------------------------- ALK1_Mmus ----------TQTPS----------------E---------------------------- daf-1_Cele -----------------------------------------------------------P BMPR1A_Hsap ----------VIGPF--------------------------------------------- BMPR1B_Hsap ----------KNRDF--------------------------------------------- ALK7_Hsap ------------PN--------------------------------------------AP ALK4_Hsap ----------KEPE--------------------------------------------HP tkv_Dmel ----------LTTPA----------------P-------------------------DLP SAX_Dmel ----------DSNDV----------------T-------------------------VIT BABO_Dmel ----------ETDY--------------------------------------------VP TGFBR1_Mmus ----------SEKQ--------------------------------------------SA sma-6_Cele HKEKALQEKTDNPED----------------Y-------------------------DSP ALK2_Hsap ----------KGKSF----------------P---------------------------- ALK1_Hsap ----------TQPPS----------------E---------------------------- TGFbR1_Spur ------------------------------------------------------------ ALK2_Spur ----------TTPR---------------------------------------------- BMPR1_Spur ----------TTSTT----------------T-------------------------ELP AqueK680_Aque ----------VS---------------------------------------------ATP AqueK681_Aque ----------KDTSTFNNPSIIIYFSEPTNDPHLYDLTSLPTKDTSTFNNSSIIIYFSEP AqueK682_Aque ------------------------------------------------------------ TGFbR1_Hsap G-----L-GPVE-LAAVIAGPVCFVCI---SLMLMVY-I-CH-NRTVIH--HRVP---N- BMPR1B_Mmus -----VD-GPIHHKALLISVTVCSLLL---VLII-LFCY-FR-YKRQ-E--ARPR-Y-S- BMPR1A_Mmus -----FD-GSIRWLVVLISMAVCIVAM---IIFSSCFCY-KH-YCKSIS--SRGR-Y-N- ALK7_Mmus R-----L-GPTE-LTVVITVPVCLLSI---AAMLTIWAC-QD-RQCTYR--KTKR-H-N- ALK4_Mmus S----MW-GPVE-LVGIIAGPVFLLFL---IIIIVFLVI-NY-HQRVYH--NRQR-L-D- ALK2_Mmus G----TQ-NFHLEVGLIILSVVFAVCL---LACILGVAL-RK-FKRRNQ--ERLNPR-D- ALK1_Mmus E-----P-EVDAHLP-LILGPVLALPV---LVALGALGL-WR-VRRRQE--KQRD-L-H- daf-1_Cele Q----QS-S--TWLILTILA---LLT-FIVLLGIAIFL-TRKSWEAKFDWYIRFKPKPGD BMPR1A_Hsap -----FD-GSIRWLVLLISMAVCIIAM---IIFSSCFCY-KH-YCKSIS--SRRR-Y-N- BMPR1B_Hsap -----VD-GPIHHRALLISVTVCSLLL---VLII-LFCY-FR-YKRQ-E--TRPR-Y-S- ALK7_Hsap K-----L-GPME-LAIIITVPVCLLSI---AAMLTVWAC-QG-RQCSYR--KKKR-P-N- ALK4_Hsap S----MW-GPVE-LVGIIAGPVFLLFL---IIIIVFLVI-NY-HQRVYH--NRQR-L-D- tkv_Dmel V----SS-ESLHTLAVFGSIIISLSVF---MLIVASLCF--T-YKRREK--LRKQ-P-R- SAX_Dmel A----DT-SSISKMLVAVLGPFLVIAL---LGAVTIFFI-RRSHRKRLA--ASRTKQ-D- BABO_Dmel H----RL-TSWE-FVAIILGATLFICF---TGTSTWYYC-QR-RKRMAS--GR-T-F-A- TGFBR1_Mmus G-----L-GPVE-LAAVIAGPVCFVCI---ALMLMVY-I-CH-NRTVIH--HRVP---N- sma-6_Cele L----ENMTRGGKMFIMVFATVMSV--FAV-IGCIYLC-ITRA-EEKSK--ARARAK-T- ALK2_Hsap G----TQ-NFHLEVGLIILSVVFAVCL---LACLLGVAL-RK-FKRRNQ--ERLNPR-D- ALK1_Hsap Q-----P-GTDGQLA-LILGPVLALLA---LVALGVLGL-WH-VRRRQE--KQRG-L-H- TGFbR1_Spur ------------------------------------------------------------ ALK2_Spur ------------------------------------------------------------ BMPR1_Spur GVEDTYN-TTVHQIALLISVTFCAAAF---IIALT-FFY-LR-YKKR-E--VRRR-Y-D- AqueK680_Aque T----VS-SNDPSLYIIILVTIISSCIILIILFFALFIFCKRK-RDRRL--PRQRTN-D- AqueK681_Aque T----NDPQQISDLNTVIPVIVVLLVIAAVIILLAI--FIHRR-STKSN--NRGKQR-G- AqueK682_Aque ------------------------------------------------------------ TGFbR1_Hsap -EEDPSLDRPF----------------------------------ISEGTTLKDLIYD-M BMPR1B_Mmus -IGL-EQDETY----------------------------------IPPGESLRDLIEQ-S BMPR1A_Mmus -RDL-EQDEAF----------------------------------IPVGESLKDLIDQ-S ALK7_Mmus -VEEALAEYSL----------------------------------VNAGKTLKDLIYD-A ALK4_Mmus -MEDPSC-EMC----------------------------------LSKDKTLQDLVYD-L ALK2_Mmus -VEYGT-IEGLI-T------------------------------TNVGDSTLAELLDH-S ALK1_Mmus -SDLGE-SSLILKA------------------------------SEQADSMLGDFLDS-D daf-1_Cele PLRETENNVPMVTMGDGAGSSVPEVAPIEQQGSTMSTSAGNSFPPGIMPNNMKDMLDVLE BMPR1A_Hsap -RDL-EQDEAF----------------------------------IPVGESLKDLIDQ-S BMPR1B_Hsap -IGL-EQDETY----------------------------------IPPGESLRDLIEQ-S ALK7_Hsap -VEEPLSECNL----------------------------------VNAGKTLKDLIYD-V ALK4_Hsap -MEDPSC-EMC----------------------------------LSKDKTLQDLVYD-L tkv_Dmel -L--I--NSMC----------------------------------NSQLSPLSQLVE--- SAX_Dmel -PEAYLVNDELLRA------------------------------TSAGDSTLREYLQH-S BABO_Dmel -KEDSA-YDPI----------------------------------LNGNTTIHDIIEM-- TGFBR1_Mmus -EEDPSLDRPF----------------------------------ISEGTTLKDLIYD-M sma-6_Cele -VSL-KTE-----------------------------------------STYMESKSM-L ALK2_Hsap -VEYGT-IEGLI-T------------------------------TNVGDSTLADLLDH-S ALK1_Hsap -SELGE-SSLILKA------------------------------SEQGDSMLGDLLDS-D TGFbR1_Spur ------------------------------------------------------------ ALK2_Spur -----------I----------------------------------TEGLFCFDLFDH-S BMPR1_Spur -FEVAQQDDSF----------------------------------IGPGETLSELLEK-S AqueK680_Aque -PDV-HLTEPH--H------------------------------SNGNGNDLTSFLQM-S AqueK681_Aque -NEG----S----T------------------------------KVRP-EDVEREMEI-L AqueK682_Aque ------------------------------------------------------------ TGFbR1_Hsap TTSGSG-SGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWF BMPR1B_Mmus QSSGSG-SGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWF BMPR1A_Mmus QSSGSG-SGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWF ALK7_Mmus TASGSG-SGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWF ALK4_Mmus STSGSG-SGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWF ALK2_Mmus CTSGSG-SGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWF ALK1_Mmus CTTGSG-SGLPFLVQRTVARQVALVECVGKGRYGEVWRGSWHGESVAVKIFSSRDEQSWF daf-1_Cele ETSGSG-MGPTTLHKLTIGGQIRLTGRVGSGRFGNVSRGDYRGEAVAVKVFNALDEPAFH BMPR1A_Hsap QSSGSG-SGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWF BMPR1B_Hsap QSSGSG-SGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWF ALK7_Hsap TASGSG-SGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWF ALK4_Hsap STSGSG-SGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWF tkv_Dmel QSSGSG-SGLPLLVQRTIAKQIQMVRLVGKGRYGEVWLAKWRDERVAVKTFFTTEEASWF SAX_Dmel VTSGSG-SGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWK BABO_Dmel TTSGSGSAGLPLLVQRSIARQVQLCHVIGKGRFGEVWRGRWRGENVAVKIFSSREECSWF TGFBR1_Mmus TTSGSG-SGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWF sma-6_Cele EDSGSG-SGQAALIQRTVRQDLTIIKTIGQGRYGEVRKALYRGSYVAVKTFYTTDEDSWK ALK2_Hsap CTSGSG-SGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWF ALK1_Hsap CTTGSG-SGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWF TGFbR1_Spur -----GIQGLPLLVQRTIARQIVIQDCIGKGRYGEVYRGKWRGESVAVKIFSSREERSWF ALK2_Spur NTSGSG-SGLPYLVQRTVARQINLLQQVGKGRYGEVWMGTWQGDTVAVKIFSSIDEKSWF BMPR1_Spur SASGSG-SGLPLLVQRTIAKQVQLIRKIGKGRYGEVWKAKWRGENVAVKIYFTAEEASWF AqueK680_Aque FTSGSG-AGMPFLVKRTIARSILLGESIGGGRFGQVYVGHYQGERYAVKKFFSKDEQSWF AqueK681_Aque STSGSG-MGERVLTSRTIAMDITIHEHLGRGTYGSISRCTYRGNTFAVKRFTTINESSFR AqueK682_Aque ------------------SHDVTKISVIGQGRFGKVWRCSYEEKHIAMKVFKNMHMAVFK : :* * :*.: : *:* : . : TGFbR1_Hsap REAEIYQTVMLRHENILGFIAADNKD-NGTWTQLWLVSDYHEHGSLFDYLNR-YT-VTVE BMPR1B_Mmus RETEIYQTVLMRHENILGFIAADIKG-TGSWTQLYLITDYHENGSLYDYLKS-TT-LDAK BMPR1A_Mmus RETEIYQTVLMRHENILGFIAADIKG-TGSWTQLYLITDYHENGSLYDFLKC-AT-LDTR ALK7_Mmus REAEIYQTVMLRHENILGFIAADNKD-NGTWTQLWLVSEYHEQGSLYDYLNR-NI-VTVA ALK4_Mmus REAEIYQTVMLRHENILGFIAADNKD-NGTWTQLWLVSDYHEHGSLFDYLNR-YT-VTIE ALK2_Mmus RETELYNTVMLRHENILGFIASDMTS-RHSSTQLWLITHYHEMGSLYDYLQL-TT-LDTV ALK1_Mmus RETEIYNTVLLRHDNILGFIASDMTS-RNSSTQLWLITHYHEHGSLYDFLQR-QT-LEPQ daf-1_Cele KETEIFETRMLRHPNVLRYIGSDRVD-TGFVTELWLVTEYHPSGSLHDFLLE-NT-VNIE BMPR1A_Hsap RETEIYQTVLMRHENILGFIAADIKG-TGSWTQLYLITDYHENGSLYDFLKC-AT-LDTR BMPR1B_Hsap RETEIYQTVLMRHENILGFIAADIKG-TGSWTQLYLITDYHENGSLYDYLKS-TT-LDAK ALK7_Hsap REAEIYQTVMLRHENILGFIAADNKD-NGTWTQLWLVSEYHEQGSLYDYLNR-NI-VTVA ALK4_Hsap REAEIYQTVMLRHENILGFIAADNKD-NGTWTQLWLVSDYHEHGSLFDYLNR-YT-VTIE tkv_Dmel RETEIYQTVLMRHDNILGFIAADIKG-NGSWTQMLLITDYHEMGSLHDYLSM-SV-INPQ SAX_Dmel RETEIYSTILLRHENILGFIGSDMTS-RNSCTQLWLMTHYYPLGSLFDHLNR-NA-LSHN BABO_Dmel REAEIYQTVMLRHENILGFIAADNKD-NGTWTQLWLVTDYHENGSLFDYLTT-HP-VDTN TGFBR1_Mmus REAEIYQTVMLRHENILGFIAADNKD-NGTWTQLWLVSDYHEHGSLFDYLNR-YT-VTVE sma-6_Cele NERDVYQTNMINHENILQFVAADIWSEEDSMTKMLLITDYHELGSLSDYLCREET-LTTD ALK2_Hsap RETELYNTVMLRHENILGFIASDMTS-RHSSTQLWLITHYHEMGSLYDYLQL-TT-LDTV ALK1_Hsap RETEIYNTVLLRHDNILGFIASDMTS-RNSSTQLWLITHYHEHGSLYDFLQR-QT-LEPH TGFbR1_Spur REAEIYQTVMLRHENILGFIAADNKD-NGTWTQLILVSDYHENGSLFDYLNS-HV-IDVP ALK2_Spur RETEIYNTVMLRHENILAFFASDMTS-RQSCTQLWLIMEYHERGSLYDYLNR-HV-LDAR BMPR1_Spur RETDIYQTVLMRHTSILSFIAADIRG-SGAYTQLFLITEYHEWGSLYDFLNV-NI-LDSQ AqueK680_Aque HESDIYNSVNLRHDNILTCFATDMLS-NNGVTELWLITQYHPRGSLFEELNR-GG-LTPE AqueK681_Aque RELGIYSF-SLTQTNILTYIAADMIT-IDGVMECWLILQYCPRGSLYMELTS-SP-PSLE AqueK682_Aque REVEIYDTYMLYHENILRFIGHDQIE-FADTIELRLYTEYHENGTLQDYLKS-KPVFHFP .* ::. : : .:* .. * : * .* *:* * TGFbR1_Hsap GMIKLALSTASGLAHLHMEIV--GTQ--GKPAIAHRDLKSKNILVKKNGTCCIADLGLAV BMPR1B_Mmus SMLKLAYSSVSGLCHLHTEIF--STQ--GKPAIAHRDLKSKNILVKKNGTCCIADLGLAV BMPR1A_Mmus ALLKLAYSAACGLCHLHTEIY--GTQ--GKPAIAHRDLKSKNILIKKNGSCCIADLGLAV ALK7_Mmus GMVKLALSIASGLAHLHMEIV--GTQ--GKPAIAHRDIKSKNILVKKCDTCAIADLGLAV ALK4_Mmus GMIKLALSAASGLAHLHMEIV--GTQ--GKPGIAHRDLKSKNILVKKNGMCAIADLGLAV ALK2_Mmus SCLRIVLSIASGLAHLHIEIF--GTQ--GKSAIAHRDLKSKNILVKKNGQCCIADLGLAV ALK1_Mmus LALRLAVSAACGLAHLHVEIF--GTQ--GKPAIAHRDLKSRNVLVKSNLQCCIADLGLAV daf-1_Cele TYYNLMRSTASGLAFLHNQIG--GSKESNKPAMAHRDIKSKNIMVKNDLTCAIGDLGLSL BMPR1A_Hsap ALLKLAYSAACGLCHLHTEIY--GTQ--GKPAIAHRDLKSKNILIKKNGSCCIADLGLAV BMPR1B_Hsap SMLKLAYSSVSGLCHLHTEIF--STQ--GKPAIAHRDLKSKNILVKKNGTCCIADLGLAV ALK7_Hsap GMIKLALSIASGLAHLHMEIV--GTQ--GKPAIAHRDIKSKNILVKKCETCAIADLGLAV ALK4_Hsap GMIKLALSAASGLAHLHMEIV--GTQ--GKPGIAHRDLKSKNILVKKNGMCAIADLGLAV tkv_Dmel KLQLLAFSLASGLAHLHDEIF--GTP--GKPAIAHRDIKSKNILVKRNGQCAIADFGLAV SAX_Dmel DMVWICLSIANGLVHLHTEIF--GKQ--GKPAMAHRDLKSKNILVTSNGSCVIADFGLAV BABO_Dmel TMLNMSLSIATGLAHLHMDIV--GTR--GKPAIAHRDLKSKNILVKSNLSCAIGDLGLAV TGFBR1_Mmus GMIKLALSTASGLAHLHMEIV--GTQ--GKPAIAHRDLKSKNILVKKNGTCCIADLGLAV sma-6_Cele EALRLIHSCICGIEHLHAAVH--GTGSFRKPEIAHRDIKSKNIIVKRPNVCCIADLGLAL ALK2_Hsap SCLRIVLSIASGLAHLHIEIF--GTQ--GKPAIAHRDLKSKNILVKKNGQCCIADLGLAV ALK1_Hsap LALRLAVSAACGLAHLHVEIF--GTQ--GKPAIAHRDFKSRNVLVKSNLQCCIADLGLAV TGFbR1_Spur GMLRMALSIATGLAHLHMEIM--GMQ--GKPAIAHRDIKSKNILVKRNGQCAIADLGLAV ALK2_Spur QMCRLALTACSGLVHLHTEIT--CNN--SKPAIAHRDIKTKNILVKRNLTCCIADLGLAV BMPR1_Spur SMLRLAYSAANGLAHLHTEIC--GMQ--GKPAIAHRDVKSSNIMVRKNGTCMIADMSLAA AqueK680_Aque TTLKFIHSTCRGLAYLHLEIT--GTQ--GKPSVAHRDIKSKNILVKNDSTCCIADFGLAV AqueK681_Aque TGVRMVYSACMGLSYLHSSLQGYGPI--AKPRIAHRDIKSKNILMKTAETCCIADFGLSI AqueK682_Aque ECHQMAVSLSSGLTYLHKTIV--AGK--IKPGIAHRDLKSSNILVKTDYTLCIADLGLAI : : *: .** : *. :****.*: *::: *.*:.*: TGFbR1_Hsap R----------------------------------------------------------- BMPR1B_Mmus K----------------------------------------------------------- BMPR1A_Mmus K----------------------------------------------------------- ALK7_Mmus K----------------------------------------------------------- ALK4_Mmus R----------------------------------------------------------- ALK2_Mmus M----------------------------------------------------------- ALK1_Mmus M----------------------------------------------------------- daf-1_Cele S----------------------------------------------------------- BMPR1A_Hsap K----------------------------------------------------------- BMPR1B_Hsap K----------------------------------------------------------- ALK7_Hsap K----------------------------------------------------------- ALK4_Hsap R----------------------------------------------------------- tkv_Dmel K----------------------------------------------------------- SAX_Dmel T----------------------------------------------------------- BABO_Dmel R----------------------------------------------------------- TGFBR1_Mmus R----------------------------------------------------------- sma-6_Cele R----------------------------------------------------------- ALK2_Hsap M----------------------------------------------------------- ALK1_Hsap M----------------------------------------------------------- TGFbR1_Spur R----------------------------------------------------------- ALK2_Spur L----------------------------------------------------------- BMPR1_Spur RFLSEGNEIDLGQNTRLGTTRYLPPEVLDNVLMSNTFDAFKMADMYSFGMVLWEIARRCV AqueK680_Aque N----------------------------------------------------------- AqueK681_Aque A----------------------------------------------------------- AqueK682_Aque K----------------------------------------------------------- TGFbR1_Hsap ------------------------------------------------------------ BMPR1B_Mmus ------------------------------------------------------------ BMPR1A_Mmus ------------------------------------------------------------ ALK7_Mmus ------------------------------------------------------------ ALK4_Mmus ------------------------------------------------------------ ALK2_Mmus ------------------------------------------------------------ ALK1_Mmus ------------------------------------------------------------ daf-1_Cele ------------------------------------------------------------ BMPR1A_Hsap ------------------------------------------------------------ BMPR1B_Hsap ------------------------------------------------------------ ALK7_Hsap ------------------------------------------------------------ ALK4_Hsap ------------------------------------------------------------ tkv_Dmel ------------------------------------------------------------ SAX_Dmel ------------------------------------------------------------ BABO_Dmel ------------------------------------------------------------ TGFBR1_Mmus ------------------------------------------------------------ sma-6_Cele ------------------------------------------------------------ ALK2_Hsap ------------------------------------------------------------ ALK1_Hsap ------------------------------------------------------------ TGFbR1_Spur ------------------------------------------------------------ ALK2_Spur ------------------------------------------------------------ BMPR1_Spur TRGFIAADIRGSGAYTQLFLITEYHEWGSLYDFLNVNILDSQSMLRLAYSAANGLAHLHT AqueK680_Aque ------------------------------------------------------------ AqueK681_Aque ------------------------------------------------------------ AqueK682_Aque ------------------------------------------------------------ TGFbR1_Hsap ---------------------------------------HDSAT-DTID-IAPNHRVGTK BMPR1B_Mmus ---------------------------------------FISDT-NEVD-IPPNTRVGTK BMPR1A_Mmus ---------------------------------------FNSDT-NEVD-IPLNTRVGTK ALK7_Mmus ---------------------------------------HDSIM-NTID-IPQNPKVGTK ALK4_Mmus ---------------------------------------HDAVT-DTID-IAPNQRVGTK ALK2_Mmus ---------------------------------------HSQST-NQLD-VGNNPRVGTK ALK1_Mmus ---------------------------------------HSQSS-DYLD-IGNNPRVGTK daf-1_Cele ---------------------------------------KPEDAASDII-ANENYKCGTV BMPR1A_Hsap ---------------------------------------FNSDT-NEVD-VPLNTRVGTK BMPR1B_Hsap ---------------------------------------FISDT-NEVD-IPPNTRVGTK ALK7_Hsap ---------------------------------------HDSIL-NTID-IPQNPKVGTK ALK4_Hsap ---------------------------------------HDAVT-DTID-IAPNQRVGTK tkv_Dmel ---------------------------------------YNSEL-DVIH-IAQNPRVGTR SAX_Dmel ---------------------------------------HSHVT-GQLD-LGNNPKVGTK BABO_Dmel ---------------------------------------HVEKN-DSVD-IPSTHRVGTK TGFBR1_Mmus ---------------------------------------HDSAT-DTID-IAPNHRVGTK sma-6_Cele ---------------------------------------YQND-K-ILP-EKFNVQVGTK ALK2_Hsap ---------------------------------------HSQST-NQLD-VGNNPRVGTK ALK1_Hsap ---------------------------------------HSQGS-DYLD-IGNNPRVGTK TGFbR1_Spur ---------------------------------------HDSVT-DTVD-IFPNNRIGTK ALK2_Spur ---------------------------------------HTQRE-DNID-MGTNTRVGTK BMPR1_Spur EICGMQGKPAIAHRDVKSSNIMVRKNGTCMIADMSLAARFLSEG-NEID-LGQNTRLGTT AqueK680_Aque ---------------------------------------YLN--------FNNNVQQGTK AqueK681_Aque ---------------------------------------DSEDF----Q-SFICLKQGTN AqueK682_Aque ---------------------------------------QSESG-DGVDQIPANKLSGTK ** TGFbR1_Hsap RYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI--G------GIHE------ BMPR1B_Mmus RYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEIARRCVS--G------GIVE------ BMPR1A_Mmus RYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCIT--G------GIVE------ ALK7_Mmus RYMAPEMLDDTMNLSIFESFKRADIYSVGLVYWEIARRCSV--G------GVVE------ ALK4_Mmus RYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNS--G------GVHE------ ALK2_Mmus RYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS--N------GIVE------ ALK1_Mmus RYMAPEVLDEHIRTDCFESYKWTDIWAFGLVLWEIARRTII--N------GIVE------ daf-1_Cele RYLAPEILNSTMQFTVFESYQCADVYSFSLVMWETLCRCED--G------DVLP------ BMPR1A_Hsap RYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCIT--G------GIVE------ BMPR1B_Hsap RYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVS--G------GIVE------ ALK7_Hsap RYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSV--G------GIVE------ ALK4_Hsap RYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNS--G------GVHE------ tkv_Dmel RYMAPEVLSQQLDPKQFEEFKRADMYSVGLVLWEMTRRCYT--PVSGTKTTTCE------ SAX_Dmel RYMAPEVLDESIDLECFEALRRTDIYAFGLVLWEVCRRTIS--C------GIAE------ BABO_Dmel RYMAPEVLDESMNDQHFDSYKRADVYAFGLILWEIARRCNM--G------MIYD------ TGFBR1_Mmus RYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI--G------GIHE------ sma-6_Cele RYMAPELISNKLNPKDFSQFKMADIYSMALVMWEVAIRVEV--N------TCEEVLTVDE ALK2_Hsap RYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS--N------GIVE------ ALK1_Hsap RYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIV--N------GIVE------ TGFbR1_Spur RYMAPEVLDDTINMNHFDSFKRADVYSFGLVLWEIGRRCQV--F------GIYE------ ALK2_Spur RYMAPELLEETMDVRCFESFKRVDVYAFGLVMWEIARRCEV--G------GMVA------ BMPR1_Spur RYLPPEVLDNVLMSNTFDAFKMADMYSFGMVLWEIARRCVT--R------GIVE------ AqueK680_Aque RYMPPEVIKGTIDVHSFESFLRADIYSFGLVMWEVCTRCHL--E------GPLA------ AqueK681_Aque RYMAPEILNETIDVKDFVSFLRADVYSFALVAWEVFNRCNIEQG------GIAR------ AqueK682_Aque RYMSPEILNESLDYGRFICYAQSDIYSFSLIIWEIFNCCEI--D------GVPR------ **:.**::. : * *:::..:: ** TGFbR1_Hsap -----------------------------------------DYQLPYYDLVPSDPSVEEM BMPR1B_Mmus -----------------------------------------EYQLPYHDLVPSDPSYEDM BMPR1A_Mmus -----------------------------------------EYQLPYYNMVPSDPSYEDM ALK7_Mmus -----------------------------------------EYQLPYYDMVPSDPSIEEM ALK4_Mmus -----------------------------------------DYQLPYYDLVPSDPSIEEM ALK2_Mmus -----------------------------------------DYKPPFYDVVPNDPSFEDM ALK1_Mmus -----------------------------------------DYRPPFYDMVPNDPSFEDM daf-1_Cele --------------------------------------REAATVIPYIEWTDRDPQDAQM BMPR1A_Hsap -----------------------------------------EYQLPYYNMVPSDPSYEDM BMPR1B_Hsap -----------------------------------------EYQLPYHDLVPSDPSYEDM ALK7_Hsap -----------------------------------------EYQLPYYDMVPSDPSIEEM ALK4_Hsap -----------------------------------------EYQLPYYDLVPSDPSIEEM tkv_Dmel -----------------------------------------DYALPYHDVVPSDPTFEDM SAX_Dmel -----------------------------------------EYKVPFYDVVPMDPSFEDM BABO_Dmel -----------------------------------------EYQLPYYDVVQPDPSIEEM TGFBR1_Mmus -----------------------------------------DYQLPYYDLVPSDPSVEEM sma-6_Cele TSPDHSASSGIGESVSSSGNISRMHLQKTNVEGHSTSLKAKQHVPPFDGIVHNDPNFDEM ALK2_Hsap -----------------------------------------DYKPPFYDVVPNDPSFEDM ALK1_Hsap -----------------------------------------DYRPPFYDVVPNDPSFEDM TGFbR1_Spur -----------------------------------------EFCLPYHPWVPMDPPIDDM ALK2_Spur -----------------------------------------DYKPPFFEYVPSDPSFDDM BMPR1_Spur -----------------------------------------ECQLPFYDAVPMDPSIQDM AqueK680_Aque -----------------------------------------DYALPFQSQVPPDPTLDDM AqueK681_Aque -----------------------------------------EYQLPYSDHLPNNSSIEDC AqueK682_Aque -----------------------------------------SYQLPYCEWVPTDPDIDQM *: :. : TGFbR1_Hsap RKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQ-E- BMPR1B_Mmus REIVCMKKLRPSFPNRWSSDECLRQMGKLMTECWAQNPASRLTALRVKKTLAKMSES-Q- BMPR1A_Mmus REVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVES-Q- ALK7_Mmus RKVVCDQKLRPNLPNQWQSCEALRVMGRIMRECWYANGAARLTALRVKKTISQLCVK-E- ALK4_Mmus RKVVCDQKLRPNVPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQ-E- ALK2_Mmus RKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNS-LD ALK1_Mmus KKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKLSHN-PE daf-1_Cele FDVVCTRRLRPTENPLWKDHPEMKHIMEIIKTCWNGNPSARFTSYICRKRMDERQQLLLD BMPR1A_Hsap REVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVES-Q- BMPR1B_Hsap REIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSES-Q- ALK7_Hsap RKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVK-E- ALK4_Hsap RKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQ-E- tkv_Dmel HAVVCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPNPTVRLTALRVKKTLGRLETD-CL SAX_Dmel RKVVCIDNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLASA-DE BABO_Dmel KKVVCIEKCRPNIPNRWHASDVLHNMAKVMKECWYPNPVARLTALRIKKTLASISVE-D- TGFBR1_Mmus RKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQ-E- sma-6_Cele NDVICVRRIRPPPDLAWKNVPALNELSKLMEDSWHSIPHFRHSALKLKKEMAELIKN-PD ALK2_Hsap RKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNS-LD ALK1_Hsap KKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKISNS-PE TGFbR1_Spur RRIVCIEKRRPPVPNRWNSHKIMESYAKVMKECWYQNGAARLTALRIKKTLAGLMGP-SE ALK2_Spur RKVACIEKLRPNIPNRWTNNTVLTSMAKLMKECWCPTASARHTSLRVKKTLMKISET-CP BMPR1_Spur MRVVVIERRRPDIPNRWSGDDILRTISKVMSECWNQNPAARVTSLRVKKTLGKLQEN--- AqueK680_Aque TEFIVGKEVIPEIPETWSNNELLRGMSRVMYECWYHQPTARPSAYYIRKKVDKIAEM-CE AqueK681_Aque RRVVVEEGTRP-VTSEWSKTRFLEKLSVTIKELWAERGSERPSIELLRKKIEKEART-YD AqueK682_Aque KQCVCVNNRRPTIPDSWTESETLSPIAKLLDSSWATQASSRISALRISKILKGIDFK-K- * : : * * . * : TGFbR1_Hsap ------------------------------------------------------------ BMPR1B_Mmus ------------------------------------------------------------ BMPR1A_Mmus ------------------------------------------------------------ ALK7_Mmus ------------------------------------------------------------ ALK4_Mmus ------------------------------------------------------------ ALK2_Mmus ------------------------------------------------------------ ALK1_Mmus ------------------------------------------------------------ daf-1_Cele K----------------------------------------------------------- BMPR1A_Hsap ------------------------------------------------------------ BMPR1B_Hsap ------------------------------------------------------------ ALK7_Hsap ------------------------------------------------------------ ALK4_Hsap ------------------------------------------------------------ tkv_Dmel I----------------------------------------------------------- SAX_Dmel ------------------------------------------------------------ BABO_Dmel ------------------------------------------------------------ TGFBR1_Mmus ------------------------------------------------------------ sma-6_Cele R----------------------------------------------------------- ALK2_Hsap ------------------------------------------------------------ ALK1_Hsap ------------------------------------------------------------ TGFbR1_Spur P----------------------------------------------------------- ALK2_Spur ------------------------------------------------------------ BMPR1_Spur ------------------------------------------------------------ AqueK680_Aque ------------------------------------------------------------ AqueK681_Aque DCNNLSTLIDIVQATIFIVVFRMLRLLAKIPLFGIILKSLIRVLVLLIPFLLLGYLFYFE AqueK682_Aque ------------------------------------------------------------ TGFbR1_Hsap ------------------------------------------------------------ BMPR1B_Mmus ------------------------------------------------------------ BMPR1A_Mmus ------------------------------------------------------------ ALK7_Mmus ------------------------------------------------------------ ALK4_Mmus ------------------------------------------------------------ ALK2_Mmus ------------------------------------------------------------ ALK1_Mmus ------------------------------------------------------------ daf-1_Cele ------------------------------------------------------------ BMPR1A_Hsap ------------------------------------------------------------ BMPR1B_Hsap ------------------------------------------------------------ ALK7_Hsap ------------------------------------------------------------ ALK4_Hsap ------------------------------------------------------------ tkv_Dmel ------------------------------------------------------------ SAX_Dmel ------------------------------------------------------------ BABO_Dmel ------------------------------------------------------------ TGFBR1_Mmus ------------------------------------------------------------ sma-6_Cele ------------------------------------------------------------ ALK2_Hsap ------------------------------------------------------------ ALK1_Hsap ------------------------------------------------------------ TGFbR1_Spur ------------------------------------------------------------ ALK2_Spur ------------------------------------------------------------ BMPR1_Spur ------------------------------------------------------------ AqueK680_Aque ------------------------------------------------------------ AqueK681_Aque FAIVGMAIFRGVNLNDTKAAAECGSYENLKYHPYNFEDFGSTLVLLWNLMIVNNWHVIVD AqueK682_Aque ------------------------------------------------------------ TGFbR1_Hsap ------------------------------------------------------------ BMPR1B_Mmus ------------------------------------------------------------ BMPR1A_Mmus ------------------------------------------------------------ ALK7_Mmus ------------------------------------------------------------ ALK4_Mmus ------------------------------------------------------------ ALK2_Mmus --------------------------------------------------------K--- ALK1_Mmus --------------------------------------------------------K--- daf-1_Cele --------------------------------------------------------K--A BMPR1A_Hsap ------------------------------------------------------------ BMPR1B_Hsap ------------------------------------------------------------ ALK7_Hsap ------------------------------------------------------------ ALK4_Hsap ------------------------------------------------------------ tkv_Dmel --------------------------------------------------------D--- SAX_Dmel --------------------------------------------------------K--I BABO_Dmel ------------------------------------------------------------ TGFBR1_Mmus ------------------------------------------------------------ sma-6_Cele --------------------------------------------------------Q--N ALK2_Hsap --------------------------------------------------------K--- ALK1_Hsap --------------------------------------------------------K--- TGFbR1_Spur --------------------------------------------------------E--V ALK2_Spur --------------------------------------------------------K--L BMPR1_Spur ------------------------------------------------------------ AqueK680_Aque ------------------------------------------------------------ AqueK681_Aque AYVRRTSIYSRIYFVIWWVLSETVINGILLGYLIEILSITTIRLKDVFKDFNNKSKREKL AqueK682_Aque ------------------------------------------------------------ TGFbR1_Hsap ------------------------------------------------------------ BMPR1B_Mmus ------------------------------------------------------------ BMPR1A_Mmus ------------------------------------------------------------ ALK7_Mmus ------------------------------------------------------------ ALK4_Mmus ------------------------------------------------------------ ALK2_Mmus ------------------------------------------------------------ ALK1_Mmus ------------------------------------------------------------ daf-1_Cele ------KAVAQTAGVTVQDRKILGPQKPKDESPANGAPR-------------IVQKEIDR BMPR1A_Hsap ------------------------------------------------------------ BMPR1B_Hsap ------------------------------------------------------------ ALK7_Hsap ------------------------------------------------------------ ALK4_Hsap ------------------------------------------------------------ tkv_Dmel ------------------------------------------------------------ SAX_Dmel ------R----------------------------------------------------- BABO_Dmel ------------------------------------------------------------ TGFBR1_Mmus ------------------------------------------------------------ sma-6_Cele QSQRKVEFQ--------------------------------------------------Q ALK2_Hsap ------------------------------------------------------------ ALK1_Hsap ------------------------------------------------------------ TGFbR1_Spur ------LL------------------------PPANMQNTC-------D------ASQSG ALK2_Spur ------T----------------------------------------------------- BMPR1_Spur ------------------------------------------------------------ AqueK680_Aque ------------------------------------------------------------ AqueK681_Aque ------AL-------------------------------VCLFIFVPQDLREMFRGEADY AqueK682_Aque ------------------------------------------------------------ TGFbR1_Hsap ------------------------------------------------GIKM BMPR1B_Mmus ------------------------------------------------DIKL BMPR1A_Mmus ------------------------------------------------DVKI ALK7_Mmus ------------------------------------------------DCKA ALK4_Mmus ------------------------------------------------DVKI ALK2_Mmus -----------------------------------------------LKTDC ALK1_Mmus -----------------------------------------------PKVIH daf-1_Cele EDEQENWRETAKT---PNG--------HISSND-----------DSSRPLLG BMPR1A_Hsap ------------------------------------------------DVKI BMPR1B_Hsap ------------------------------------------------DIKL ALK7_Hsap ------------------------------------------------DCKA ALK4_Hsap ------------------------------------------------DVKI tkv_Dmel ----------------------------------------------VPIKIV SAX_Dmel --------------------------------------------LDFDEVCV BABO_Dmel ------------------------------------------------KVKN TGFBR1_Mmus ------------------------------------------------GIKM sma-6_Cele QD----SG------------------------L-----------VESATNQS ALK2_Hsap -----------------------------------------------LKTDC ALK1_Hsap -----------------------------------------------PKVIQ TGFbR1_Spur DD----L----KGRLPPSAIIPTSHPPN----V-----------PNPYPILS ALK2_Spur -D------------------------------P-----------YHWEKIIA BMPR1_Spur ------------------------------------------------EFKV AqueK680_Aque --------------------------------------------VRRLDFDE AqueK681_Aque ED----L-------------------------DAFHSWNIFDATFKEKQGES AqueK682_Aque ----------------------------------------------EKIQNE