CLUSTAL W (1.83) multiple sequence alignment TAK1_Hsap MSTASAASS--------------------------------------------------- Takl2_Dmel MSAPV------------------------------------------------------- Takl1_Dmel MVKQ-------------------------------------------------------- Tak1_Dmel MATASLDA---------------------------------------------------- mom-4_Cele MDNSSQSKP--------------------------------------------------- TAK1_Mmus MSTASAASS--------------------------------------------------- Y105C5A.24_Cele MDRKPSSSS--------------------------------------------------- TAK1_Spur MARLVTQ----------------------------------------------------- AqueK667_Aque MQHSRADDG--------------------------------------------------- AqueK668_Aque MEVIA------------------------------------------------------- AqueK669_Aque MSNKAGEDV--------------------------------------------------- AqueK670_Aque MN---------------------------------------------------------- AqueK671_Aque MYRLQPAPPALMLSTAANTSPHGGPAKIRSVTLEQLPWSIVKKLTQLLDRTHPDHHNWSS AqueK672_Aque MSTQPGYDE--------------------------------------------------- AqueK673_Aque MEVIA------------------------------------------------------- AqueK674_Aque MSKAEQGVK--------------------------------------------------- * TAK1_Hsap -------------------------------S---------------------------- Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel ------------------------------------------------------------ mom-4_Cele -------------------------------S---------------------------- TAK1_Mmus -------------------------------S---------------------------- Y105C5A.24_Cele -------------------------------S---------------------------- TAK1_Spur ------------------------------------------------------------ AqueK667_Aque -------------------------------ILRVMGELWVSTMVNGDLLSCGWIRSLEW AqueK668_Aque ------------------------------------------------------------ AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque ------------------------------------------------------------ AqueK671_Aque LLSHAQVIGIKYTADEVANFQSVANRVAGSPS---------------------------- AqueK672_Aque -------------------------------A---------------------------- AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque ------------------------------------------------------------ TAK1_Hsap ------------------------------------------------------------ Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel ------------------------------------------------------------ mom-4_Cele ------------------------------------------------------------ TAK1_Mmus ------------------------------------------------------------ Y105C5A.24_Cele ------------------------------------------------------------ TAK1_Spur ------------------------------------------------------------ AqueK667_Aque VCPTCGVANRTALPEGSEEEA--------------------------------------- AqueK668_Aque ------------------------------------------------------------ AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque ------------------------------------------------------------ AqueK671_Aque -------------------EAIINDFIVRCVTTDDLYLILKDMEHKRGMELLEEYVSLRL AqueK672_Aque ------------------------------------------------------------ AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque ------------------------------------------------------------ TAK1_Hsap ------------------------------------------------------------ Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel ------------------------------------------------------------ mom-4_Cele ------------------------------------------------------------ TAK1_Mmus ------------------------------------------------------------ Y105C5A.24_Cele ------------------------------------------------------------ TAK1_Spur ------------------------------------------------------------ AqueK667_Aque ------------------------------------------------------------ AqueK668_Aque ------------------------------------------------------------ AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque ------------------------------------------------------------ AqueK671_Aque LPPNTKSSDSMRGGSAQGNGGGGEADQSRANGSNGLQYTYHPEVGPLPINVPNTVISTTV AqueK672_Aque ------------------------------------------------------------ AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque ------------------------------------------------------------ TAK1_Hsap ------------------------------------------------------------ Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel ------------------------------------------------------------ mom-4_Cele ------------------------------------------------------------ TAK1_Mmus ------------------------------------------------------------ Y105C5A.24_Cele ------------------------------------------------------------ TAK1_Spur ------------------------------------------------------------ AqueK667_Aque ------------------------------------------------------------ AqueK668_Aque ------------------------------------------------------------ AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque ------------------------------------------------------------ AqueK671_Aque LRVPQDQQHDNHHMPSNQFLINAHHHSSSPASQYQSQSPGIQSPGCFFSPVGDTPTAQFS AqueK672_Aque ------------------------------------------------------------ AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque ------------------------------------------------------------ TAK1_Hsap ------------------------------------------------------------ Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel ------------------------------------------------------------ mom-4_Cele ------------------------------------------------------------ TAK1_Mmus ------------------------------------------------------------ Y105C5A.24_Cele ------------------------------------------------------------ TAK1_Spur ------------------------------------------------------------ AqueK667_Aque ------------------------------------------------------------ AqueK668_Aque ------------------------------------------------------------ AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque ------------------------------------------------------------ AqueK671_Aque SPPPPPYSPLVHYPPSLDSSFHDSRAQRHYEGGGGVMMCSPQSHDGYHGTSPVFTPQTVP AqueK672_Aque ------------------------------------------------------------ AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque ------------------------------------------------------------ TAK1_Hsap ----------------SSSSA-------------------G------------------- Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel ------------------------------------------------------------ mom-4_Cele ----------------SSSSSHSP----------------S------------------- TAK1_Mmus ----------------SSSSA-------------------S------------------- Y105C5A.24_Cele ----------------T----GPP----------------A------------------- TAK1_Spur ------------------------------------------------------------ AqueK667_Aque ----------------RDTKIT----------------KEM------------------- AqueK668_Aque ------------------------------------------------------------ AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque ------------------------------------------------------------ AqueK671_Aque SPWCERQLDGIVSRPSNSSTSSSPTNCTPSP---------SLSSAPSSVPSSAPSSLPPP AqueK672_Aque ----------------RPSHSI-V--GREGSGERLMEHGDH------------------- AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque ------------------------------------------------------------ TAK1_Hsap ---------EMIEAPSQVL----------NFEEIDYKE---------------------- Takl2_Dmel -------------------------------EGVPYEE---------------------- Takl1_Dmel ---------------------------------VDFAE---------------------- Tak1_Dmel ------------------L----------QAAYVDFSE---------------------- mom-4_Cele ---------PAAITPTQRTTRDSGLCSTIDIPEIQAQCI--------------------- TAK1_Mmus ---------EMIEAPSQVL----------NFEEIDYKE---------------------- Y105C5A.24_Cele ---------PVI----QRKTRDSDLCLTSDIPKIPPNCI--------------------- TAK1_Spur -----------------MS----------FKEEVEFND---------------------- AqueK667_Aque ---------EDIVSQMAIK----------SQEEVDAQFKQQVQRQSEASHVPQPRPPSTD AqueK668_Aque -----------------------------------PNQ---------------------- AqueK669_Aque ---------EEVVAGMEYP----------VIEEISLKF---------------------- AqueK670_Aque ------------------------------------------------------------ AqueK671_Aque SSSSSSAAASNNDIKLSIL----------RFSYADLSTA--------------------- AqueK672_Aque ---------NKVFLPIGCP----------LVEEASMKF---------------------- AqueK673_Aque -----------------------------------PNQ---------------------- AqueK674_Aque ----------KVRLKIECP----------IIEETTLEF---------------------- TAK1_Hsap ------------------------------------------------------------ Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel ------------------------------------------------------------ mom-4_Cele ------------------------------------------------------------ TAK1_Mmus ------------------------------------------------------------ Y105C5A.24_Cele ------------------------------------------------------------ TAK1_Spur ------------------------------------------------------------ AqueK667_Aque QSNRRNIDIKESHDEYKDEGGTEINKESSTSGIRYRGQEETDQPLPPPPSLSPPPLPPSV AqueK668_Aque ------------------------------------------------------------ AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque ------------------------------------------------------------ AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque ------------------------------------------------------------ AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque ------------------------------------------------------------ TAK1_Hsap --IEVEEVVGRGAFGVVCK-AKWRA------KDVAIKQIESES---------------ER Takl2_Dmel --IQTKELIGTGFYGSVYR-AVWRN------REIALKRIREGC---------------ED Takl1_Dmel V-KLSEKFLGAGSGGAVRK-ATFQN------QEIAVKIFDFLEET-------------IK Tak1_Dmel --ITLREKVGHGSYGVVCK-AVWRD------KLVAVKEFFASA---------------EQ mom-4_Cele D-NLNSHYLGKGTYGLVEK-TRYRKTRQDDFRPAAIKYSSQL----------------HM TAK1_Mmus --IEVEEVVGRGAFGVVCK-AKWRA------KDVAIKQIESES---------------ER Y105C5A.24_Cele D-ELNSHFLGKGTFGVVEK-TKYRKT-----RD--------------------------- TAK1_Spur --IDFEKVVGKGAFGVVSK-ASWRG------MNVAVKMIESEE---------------EI AqueK667_Aque S-RVDGSLIGIGSSDRVRF-ATHEG------RDVAVKYSILAR---------------EH AqueK668_Aque --LEDKLMLGSGAFGCVYQ-AKWRS------RPVAVKYFNSKTIG-------------DD AqueK669_Aque --KPENTLIGVGASGRVRF-ATHKG------RDVAVKYFRSVS---------------EK AqueK670_Aque ------------------------------------------------------------ AqueK671_Aque TRIFTEGLVGHGAFGSVFR-ANIRGC-----GPYAIKKLHNRSEMQSEMEGTLFFEPLHQ AqueK672_Aque --KPDDEFLKKGSFGSIRHAATLEG------KDVAIKYFTSRD---------------IK AqueK673_Aque --LEDKLMLGSGAFGSVYK-AKWRS------RQVAVKYFNSKTIG-------------DD AqueK674_Aque --KPDQKFVEQGAYGRVCR-ATHEG------KDVAVKYFKSVE---------------EK TAK1_Hsap KAFIVELRQ---LSRVNHPNIVKLYGACLN----PVCLVMEYAEGGSLYNVLHGAEP-LP Takl2_Dmel KKIEREIYQ---LTKASHVNIVELYGTSRH--EGCALLLMEFVDGGSLSSFLHAKS--KP Takl1_Dmel KNAEREITH---LSEIDHENVIRVIGRASN--GKKDYLLMEYLEEGSLHNYLYGDD--KW Tak1_Dmel KDIEKEVKQ---LSRVKHPNIIALHGISSY--QQATYLIMEFAEGGSLHNFLHGKV--KP mom-4_Cele ATLIREAKVMWD--LRNHPNIIKIYGLYKSPR-NGQGVVMEYMDCGSMADLLYDRT--HI TAK1_Mmus KAFIVELRQ---LSRVNHPNIVKLYGACLN----PVCLVMEYAEGGSLYNVLHGAEP-LP Y105C5A.24_Cele -------------------DTYRIYGMYESHR-NGQGLVMEYMDCGCVADLIYDRK--NI TAK1_Spur KAFRVEVMQ---LSRVDHPNIVKLYGACTT--Q-PVCLVMEFAEGGSLYNVLHSSQP-QP AqueK667_Aque K-------ELEQ---EKHDNIAVLLGTGPN----ERFIIREFAP-YSLETVLHGSYPHCY AqueK668_Aque PCFEREIEALTHLQSLKHPNIIRMFARGTE--GPQTFIVMEVAL-FSLDKIIHDLKK-EY AqueK669_Aque EEFEQEVLNSKA--LQNHDNIVAILGTGPN----KLFIVREFAP-YSLNRVLHGSYPHRY AqueK670_Aque --------------TLRHPNVVLLLAASPS--PPKLAIVMEYVGGGSLYSHLHID---KT AqueK671_Aque ESFMLELQS---LVKYKHRNVLSLIAISDD--GPRPCLVYEYMENGSLADCLLGKK--NV AqueK672_Aque GGYNDELTILNA--LQTHDNIVVLLGAGLSPMTKEPFVVMEFAP-YSLNRVLHGY-PR-Y AqueK673_Aque PSFEREIEALTHLQSLKHPNIIRMFARGTE--GPQTFMVMEIAL-FSLDKIIHELKK-EY AqueK674_Aque RGYKQELVFLKC--LQEHENIVILYGTGSSPKTKEPYIVMEFAP-YSLERVLHGSHPHRY : : . :: * .: : TAK1_Hsap YYTAAHAMSWCLQCSQGVAYLHSM-QPKALIHRDLKPPNLLLVAGGT--VLKICDFGTAC Takl2_Dmel SYSHAHAFNWAHQIAQGIAYLHGM-QPKAVIHRDIKPLNTLLCEKGL--KLKICDFGTVV Takl1_Dmel EYTVEQAVRWALQCAKALAYLHSL-D-RPIVHRDIKPQNMLLYNQHE--DLKICDFGLAT Tak1_Dmel AYSLAHAMSWARQCAEGLAYLHAM-TPKPLIHRDVKPLNLLLTNKGR--NLKICDFGTVA mom-4_Cele NYTIDHVASWMFQLSSAVDFFHS----NSQVHRDLKLQNMLLSDRYR--TMKLCDFGTFT TAK1_Mmus YYTAAHAMSWCLQCSQGVAYLHSM-QPKALIHRDLKPPNLLLVAGGT--VLKICDFGTAC Y105C5A.24_Cele EYKMDHVASWMYQLSSAVNFFHS----KDQIHRDLKLQNMLLSHHHR--TLKICDFGTFT TAK1_Spur IYKAAHAMSWALQCAKGVDYLHSM-KPKKLIHRDLKPANLLLMSGGT--VLKICDFGTAC AqueK667_Aque TYEYNHVMHWARQTAVGLEYLHS----KGFLCPGIKPSNWHYYDASD------------- AqueK668_Aque DYNFNHFMSWTLQLALALECCHH----NSIIHRDINPTNLLLFDDGR--HLKICDFVTAK AqueK669_Aque TYEYDHVMHWARQIAVGLEYLHS----VRIIYRGVEPSNLLLFGNGS--LLKLCDFSHIP AqueK670_Aque IFSVDVIAQLLADITRGLQYLHSI----NILHRDLKSKNVLLTNPPPLCKAKLCDFGLAR AqueK671_Aque HLDWKLRLEIASQVADALNFLHRVNEPQSLIHGDVKSSNILL-DRHL--TPKLSDFGLAR AqueK672_Aque TYKNDHVMHWARQTALGLEYIHS----KRILYRDVKSSNLLLFGNGS--HLKLCDFGISC AqueK673_Aque DYNFNHFMSWTLQLALALECCHH----NSIIHRDIKPPNMLLFDDGR--CLKICDFGTAK AqueK674_Aque RYGVDHVMHWSRQTAVGLKHIHS----KRILHRDIKSSNLLLFGNGS--RLKLCDFGTCR : : .: * : .:: * TAK1_Hsap DI--QTH----------MTNNKGSAAWMAPEVF----------------------EGS-- Takl2_Dmel DL--SQS----------ISCNAGTCRYKAPEVRELFDFKSNRIIINQPTGFQKVLQGN-- Takl1_Dmel DM--SNN----------KTDMQGTLRYMAPEAI----------------------KHL-- Tak1_Dmel DK--STM----------MTNNRGSAAWMAPEVF----------------------EGS-- mom-4_Cele SM--HQS----------MTSNRGTPITMAPEVF----------------------RCE-- TAK1_Mmus DI--QTH----------MTNNKGSAAWMAPEVF----------------------EGS-- Y105C5A.24_Cele SI--HQS----------MTSNRGSPITMAPEIF----------------------RCE-- TAK1_Spur DF--QTY----------MTNNKGSAAWMAPEVF----------------------EGR-- AqueK667_Aque ----------------AI--HNDPVRYTAPEVL----------------------RGT-- AqueK668_Aque LL--DDA--------AFTDTFIGTPYYLAPEVV----------------------EGA-- AqueK669_Aque D---------------AL--LCGPVRYIAPEVF----------------------LDVNS AqueK670_Aque MRLESAT----------MTGNVGTVHWTAPEVL----------------------NCG-- AqueK671_Aque ES--LNRPTHVTTVSANSRVAMGTVAYMAPEFL----------------------RNS-- AqueK672_Aque NI--ETD--------ATYTSGVGTPRYMAPEVI----------------------KGT-- AqueK673_Aque LL--DA---------TSADTFIGTPYYLAPEVI----------------------EGK-- AqueK674_Aque NL--ETN--------LLYTASIGTVRYMAPEVI----------------------KGD-- .. *** TAK1_Hsap -NYS-EKCDVFSWGIILWEVITRRKPFDE---IGG----PAFRIMWAVHN-GTRPPLI-- Takl2_Dmel -KPD-EKCDVYSWAITFWEILSRKEPFEQ---YNT-----LFELYMAINE-GKR------ Takl1_Dmel -KYT-AKCDVYSFGIMLWELMTRQLPYSH---LENP--NSQYAIMKAISS-GEKLPMEAV Tak1_Dmel -KYT-EKCDIFSWAIVLWEVLSRKQPFKG---IDN-----AYTIQWKIYK-GERPPLL-- mom-4_Cele -QYN-MKSDIYSIGIIMWQIIARNHPYRR--DLS------VPGLLYNVATANLRPQ-E-- TAK1_Mmus -NYS-EKCDVFSWGIILWEVITRRKPFDE---IGG----PAFRIMWAVHN-GTRPPLI-- Y105C5A.24_Cele -PYN-MKADIFSIGIIMWQMIARDHPYTM--NMP------ITPFLYNVATRNLRPH-E-- TAK1_Spur -TYS-EKCDIFSWGVILWEVISRRKPFDD---IGG----PAFRIMWAVHN-GRRPPLI-- AqueK667_Aque -SYSTEKRDIFNFAITLWEMLARQEPVVT--E-DDT--ETIFEGLNQMAN-GRRPPLL-- AqueK668_Aque -----------------------------------------------------RMPTI-- AqueK669_Aque ISYPLEKRDIFDFAITLWEMLARQEPVVT--G-DDT--KTIFEMLNQMANA--------- AqueK670_Aque -RYH-FSADVYSFGMVLYEMVTRSIPFSH---LPPP--AV---IVAVLIR-RERPSLS-- AqueK671_Aque -KPS-SKTDVYAFGVVILELFTGQAADDPSRDIRTLHDSNMKLIFAKIVT-IELPPLV-- AqueK672_Aque -TYD-TKCDIFSFAITLWEMLARQIPTIE--GLDDN--SNIYAVFYAMAQLEKRPPLL-- AqueK673_Aque --HS-NKCDVYSFAVTLWEMITRHKPTLD---LNQEGQPHPYNVFRTIGK-GARMPTI-- AqueK674_Aque -PYT-TKCDIFSFAITLWEMLARQVPTIE--SV--S--ANSYAILYQMVQ-GKRPPLL-- TAK1_Hsap -KNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYF-------------------- Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel RSDCPEGIKQLMECCMDINPEKRPSMKEIEKFLGEQYES--------------------- Tak1_Dmel -TTCPKRIEDLMTACWKTVPEDRPSMQYIVGVMHEIVKDY-------------------- mom-4_Cele -LECNPILSEFYKKCWNDNADIRPTSSECVEYFTLLKDEY-------------------- TAK1_Mmus -KNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYF-------------------- Y105C5A.24_Cele -IECNPILSNFYKRCWSDNPASRPTSADCVEYFRCLRSEY-------------------- TAK1_Spur -RNIPKPLDKLMTS--DSSPVHSSTKDQQ-K----------------------------- AqueK667_Aque -VGHPSFVNELLQKCWNQDPGVRLTSTELVEKFKKICEHF-------------------- AqueK668_Aque -IGIPKFLWELVTKCWAQQPVDRLSFAEIVRKLKRVPYKF-------------------- AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque -SDCHQTFRTLFEKCTSWDPVDRPSLLSILRDLMLLLPSLSLPGTSGPEDETVFDHTDSL AqueK671_Aque -FACIL------------------------------------------------------ AqueK672_Aque -VGHPSFVNELLQKCWDQDPRLRPTSTELAEELGKICKNF-------------------- AqueK673_Aque -IGIPKFLWELVTKCWAQQPVDRLSFDEIVRKLKGVPYKF-------------------- AqueK674_Aque -VGHPPFVNELLEKCWDQDPAVRLTSNDLVDKFNKICEHF-------------------- TAK1_Hsap -------PGADEPLQYPCQY--------SDEGQ--------------------------- Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel --------GTDEDFIKPLD----------------------------------------- Tak1_Dmel -------TGADKALEYTFVN--QQIVTKESDGTVAA------------------------ mom-4_Cele -------PNGSVPLSDSSTN---------------------------------------- TAK1_Mmus -------PGADEPLQYPCQY--------SDEGQ--------------------------- Y105C5A.24_Cele -------PNGNVPLWDPASG---------------------------------------- TAK1_Spur ------------------------------------------------------------ AqueK667_Aque -------KFG-EPISLEYESAVGKW---MEEGSVDLTVTRVNMLGAPGAGKTCSQLLLLN AqueK668_Aque -------K-N-EPLSSRIE----NW---LKEGEVELKVTRINMHGAPGAGKTCSQRLLLN AqueK669_Aque ---------------------VGKW---MEEGSVDLTVTRVNMLGAPGAGKTCSQLLLLN AqueK670_Aque GHVMIDFDENDEQDEELMK-----F---LQEQ---------------------------- AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque -------KFG-EPIFCYDEIALEKW---MEEGSVDLTVTRVNMLGAPGAGKTCSQLLLLN AqueK673_Aque -------K-N-EPLLTRRR----------------------------------------- AqueK674_Aque -------TFG-EPLTVQEDSDD--------ED---------------------------- TAK1_Hsap -SNS-----------------------------------------ATSTGSFMDIAS--- Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel --ED-----------------------------------------TVAVVTY-------- Tak1_Dmel QPDSLSSQEGELSPSSTQ---LTPTTAANANVNAIAIS-------KTTTSSMTENTS--- mom-4_Cele ------------------------------------------------------------ TAK1_Mmus -SNS-----------------------------------------ATSTGSFMDIAS--- Y105C5A.24_Cele -------------------------------A---------------------------- TAK1_Spur ------------------------------------------------------------ AqueK667_Aque E----------DPPTNDT---STPIACPAVRATRVAVSDKM-IWNRVTRANLLDELAT-- AqueK668_Aque E----------PPPPWDKLTDSTSVACPAVQATRISIDDKNRKWEKVDIEDLLHQLASTE AqueK669_Aque E----------DPPTNDT---STPIACPAVRATKVAVSDKL-VWNRVTRANLLDELAT-- AqueK670_Aque -MES-----------------------------------------SVDGDSTLEVSS--- AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque E----------DPPTNDT---STPIACPAVRATRVAVSDKM-IWSRVTRANLLDELAT-- AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque ------------------------------------------------------------ TAK1_Hsap --------TNTSNKSDTNMEQVPA---------TNDTIK----RLESKLLKNQ------- Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ---------------------------------------------------HVDSSG--- Tak1_Dmel --------STSSDITPTNSGQLDNNPLFYMVTNRWDAIP----EEESNESRNDSFNLTSS mom-4_Cele -----------------GPAETPP---------PH------------------------- TAK1_Mmus --------TNTSNKSDTNMEQVPA---------TNDTIK----RLESKLLKNQ------- Y105C5A.24_Cele ----------------SNTVKIPK----------S------------------------- TAK1_Spur ------------------------------------------------------------ AqueK667_Aque ---------NLTTITAHSEQE--K---------TK------------------------- AqueK668_Aque VDEVPRSEDDISDSSDELSEEKPA---------TN------------------------- AqueK669_Aque ---------DLTTLTADLKQE--K---------TK------------------------- AqueK670_Aque --------NNVENVF-EDMRGVLS---------QH-ELKEYHSYTEEELVSSVSSVSSYR AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque ---------DLKTATDSEQEEVPL---------TA------------------------- AqueK673_Aque --------------SKTEVEKPPP---------SS------------------------- AqueK674_Aque ---------DDEDEEDEDESE--V---------TE------------------------- TAK1_Hsap --AKQQ---SESGRLSLGASRGSSVE----SLPPTS--EGKRM----------------- Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ----------------------------------------------------------SR Tak1_Dmel AEATQR---LETIRNGMILMACKPME----QLTLDV--EA--N----------------- mom-4_Cele ----AH---RPTM---LGTSSGSGIG--SNNRTPTA------------------------ TAK1_Mmus --AKQQ---SESGRLSLGASRGSSVE----SLPPTS--EGKRM----------------- Y105C5A.24_Cele ----QP---GGRSPLPLPKT---EI---TPDVKPKE------------------------ TAK1_Spur -----------------------------------------RH----------------- AqueK667_Aque ----QP---PAPAVLSLPDNTESSAE-VSSDLSPTPHDPTPAV----------------- AqueK668_Aque ----EP---PKKPTKNKRSESESSET-EPTENEPTKNEPTKKK----------------- AqueK669_Aque ----EP---PVPAVLSLPDNTVSSAE-VSSDLSPTPHVASPAV----------------- AqueK670_Aque VPHLVP-------ANSL-RGSAEEVA-R-VPSPPEAQE-GS-LRDDIYDTESSDRQLAER AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque ----TATFYSQSWTVTYTNPMESGNV-EIPS--HAPNEPIPAV----------------- AqueK673_Aque ---------------------DIHQIRRPDSHPPNQ-----M------------------ AqueK674_Aque ----V--------------------------PPPSPPLALQRT----------------- TAK1_Hsap ------------SA---DMSEIEAR-------IAATTAYS-KP-----K-RGHRKTASFG Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel IMR---------------------------------------V----------------- Tak1_Dmel ------------GF---DLSPSESS-------SSSTNAKS-------------------- mom-4_Cele ----------------------------------SKLLNPQQP-----G-QGHRRNRSET TAK1_Mmus ------------SA---DMSEIEAR-------IVATAAYS-KP-----K-RGHRKTASFG Y105C5A.24_Cele ----------------------------------------VAP-----A-KVQETPAL-- TAK1_Spur ------------SV---DLLDLR------------------------------------- AqueK667_Aque ------------SS---GTEDIKEDKKYHTEAVVQEILAT-QP-------KGIRKSDHWL AqueK668_Aque ---------LVQKI---STENISTENKLTNTEVGERILHA-FK-----TGKSKKLNANWV AqueK669_Aque ------------SS---DMKNIKEDKKYHTEAVVQEILAT-QP-------KGIHISDHWL AqueK670_Aque IQREERKSILA--QDYRLASELQSR-------ERFSSNY-QRPPPPPPT----------- AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque ------------L-------PLLQDKKYDTKAVVLEILAT-QP-------KEIRKSDHWL AqueK673_Aque ------------------------------------VVAF-DP-----DS--FEVVD--- AqueK674_Aque ------------QS---DMSYVKSKMAA----MSTTGSTS-DP-------PGDANNDDTG TAK1_Hsap --NILDVPEIVISGNGQPRRRS--IQDLTVT----------------------------- Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel --------------------DG--RERLTVT----------------------------- mom-4_Cele FVVQPDLPYPTVPGEAGASRI--------------------------------------- TAK1_Mmus --NILDVPEIVISGNGQPRRRS--IQDLTVT----------------------------- Y105C5A.24_Cele LPDTLKVPKV-------------------------------------------------- TAK1_Spur ------------------------------------------------------------ AqueK667_Aque --N-------A--------------------------RA--------------------- AqueK668_Aque --Y-------FIDSGGQPAYRE--LLPLFTKAAALNIITIDLTKGLDEKSNFQYRISQNM AqueK669_Aque --Y-------VIDSGGQPAYQE--LLPLFTRAASLNIITLDLSKPFNERFDLMYRIDGQY AqueK670_Aque -------------------PPYLPLKTLPTK----------------------------- AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque --Y-------VIDSGGQPAYQE--LLPLFTRAASLNIVTLDLSKPFNERFDLMYRIDGKY AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque --NGTTVQS-QLSEPYEPTSPS--VEEGFQH----------------------------- TAK1_Hsap -----------------------GTEPGQVSSRSSSPSVRM-ITTSGPTSEKPTRS---- Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel -----------------------DTKPVMMTTDLSNNNGGIHAHSNGLLSH----A---- mom-4_Cele --------------------------P-----KSQSEAKNF-RDRAKSEQRQPHRDA--- TAK1_Mmus -----------------------GTEPGQVSSRSSSPSVRM-ITTSGPTSEKPARS---- Y105C5A.24_Cele ------------------------------------------------------------ TAK1_Spur ------------------------------------------------------------ AqueK667_Aque ------------------------------------------------------------ AqueK668_Aque FPIKTKLHYSNRSIIRSTISSEAMVNPIKFPYVSDMPKHHH-YLILGTRKELVTEEKLKE AqueK669_Aque FPCHSK--STQLAFFQSAVSTGASFKPLDISCISKKPTHSM-HLVLGTHYDKVSDATLKD AqueK670_Aque ------------------------------------------------------------ AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque FPCHSK--STQLAFFQSAVSTGASFEPLDISCISKKPTHSM-HLVLGTHYDKVSDATLKE AqueK673_Aque ----------------NFEST--------------------------------S------ AqueK674_Aque -----------------------GYPPRE------------------------------- TAK1_Hsap ------------------------------------------------------------ Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel ------------------------------------------------------------ mom-4_Cele ------------------------------------------------------------ TAK1_Mmus ------------------------------------------------------------ Y105C5A.24_Cele ------------------------------------------------------------ TAK1_Spur ------------------------------------------------------------ AqueK667_Aque ------------------------------------------------------------ AqueK668_Aque MNESLINSSNLSL----KSVIWNTPQESIIFPVNTMLPAGSKEREDASMEICTE--L--S AqueK669_Aque R----------------------------------------------------------- AqueK670_Aque ------------------------------------------DRKRF---VLSEVRR--K AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque KEEILM-SSMSSLESYLQNCVISQSDDSIIFPVNAI--AASEERAKYSEEICKA--IWYR AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque ---------------------------SYI------------------------------ TAK1_Hsap ------------------------------------------------------------ Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel ------------------------------------------------------------ mom-4_Cele ------------------------------------------------------------ TAK1_Mmus ------------------------------------------------------------ Y105C5A.24_Cele ------------------------------------------------------------ TAK1_Spur ------------------------------------------------------------ AqueK667_Aque ------------------------------------------------------------ AqueK668_Aque NCRVEMTIKLPIRLFTFEISLQLEAERKK------------------------RSFLTKT AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque GHKADLKHVQPVEKRAFKVGRVI-----ESESPNVDEGPKTVWTLQKEIASFST------ AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque GSDASLKIKIPIRWFVFELSLP------E------------------------QSIVSVK AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque ------------------------------------------------------------ TAK1_Hsap ------------------------------------------------------------ Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel ------------------------------------------------------------ mom-4_Cele ------------------------------------------------------------ TAK1_Mmus ------------------------------------------------------------ Y105C5A.24_Cele ------------------------------------------------------------ TAK1_Spur ------------------------------------------------------------ AqueK667_Aque -----------------------------------------L------------------ AqueK668_Aque EVIKIGKSLRLDEESDIITALQYLHNVTIILYYGDVLENLIFINPKPILDVLSRLIAITY AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque ----------------------------------SWLNKIKFREPKPTV----------- AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque EALSIGKGCSME-KEDTKQALKYFHDVSLMLYYPEVI-NVIFIDSKPILEILSQLLALTY AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque ------------------------------------------------------------ TAK1_Hsap -----------HPWTP-------------------------------D-----D-STDTN Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel -----------NGWQA----------RDEELQEQEHEQEIVNSLDVDV-----D-PDEDE mom-4_Cele -----------RPPP-------------------------------PF-----EHRRDSN TAK1_Mmus -----------HPWTP-------------------------------D-----D-STDTN Y105C5A.24_Cele ------------------------------------------------------ERQISN TAK1_Spur -----------------------------------------------V-----D-NDNSA AqueK667_Aque ---------ILIKPLA----------Q--------------------------------- AqueK668_Aque VSQAKIQSIADPPPSP----------G--------------------------------- AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque ---------------PVGRVVTNVRKMVNR-----------------INSKVFD-EIESF AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque VNKIDAIASISDKPLS----------P--------------------------------- AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque ------------S----------------------------------------------- TAK1_Hsap GSDN----------------SI---------------------------PMAYLTLDHQL Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel --DFWRHQLPSIRMTFP------------------------------------------I Tak1_Dmel NDGT----------------EQ---------------------------SLA-EILDPEL mom-4_Cele DEEK----------------HA---------------------------VFMNICSNEET TAK1_Mmus GSDN----------------SI---------------------------PMAYLTLDHQL Y105C5A.24_Cele EEEK----------------QK---------------------------IFMTALSNEDT TAK1_Spur NDDS----------------DV---------------------------SMAYSTLEPHL AqueK667_Aque -TVM----------------KNLKEGFFNEDIFEHLKSKSVVFSLPEFQLSDLIKLLLHL AqueK668_Aque -EKN----------------SLVKLGLFKEELLAIIGK--QIFN-NDFQPSHMITLLKHL AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque STDALTHVVPKVKTILPTKED----------------------------IQ-AEKLSSPV AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque -KIT----------------KNLKEGFFNEDIFEHLKSRAEVFSLPEFQLSDLIRLLLHL AqueK673_Aque -DDT----------------LV------------------------------------SI AqueK674_Aque ------------------------------------------------------------ TAK1_Hsap QPLAPCPNSKESMAVFEQHCKMAQE-Y--------------------------------- Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel VKREA------------------------------------------------------- Tak1_Dmel QPEPPIPNDAESQLIYRDHRHMAKE-Y--------------------------------- mom-4_Cele RPIDPDTRDEKSLEIFHQHCDNNKQ-Y--------------------------------- TAK1_Mmus QPLAPCPNSKESMAVFEQHCKMAQE-Y--------------------------------- Y105C5A.24_Cele RPIDPNEGDESSLELYHQHCLVNLN-Y--------------------------------- TAK1_Spur QPLPPNPNSRESQDIFDEHMRMAQE-F--------------------------------- AqueK667_Aque NIITKLEDEQKGHYFIPYALPSYNEPVS---VEETNAKPLLI------------------ AqueK668_Aque HIIAEVENKEEGHYFFPCSLPSCDK-IE---EPSTKIQPLLI------------------ AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque APPPPAPPPPDN-------------------IPMKSKAPKQVIKTRVIGPAASNKTKMKS AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque NIITKLEDEPKGHYFIPYALPSYNEPVS---IKETNAKPLLI------------------ AqueK673_Aque EPKQANPSSQYYIDGLDPDRQYVEQ-R--------------------------------- AqueK674_Aque ----------------PVKRTSYPEGFSSFPVVKEPSGPVVV------------------ TAK1_Hsap ------------------------------------------------------------ Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel ------------------------------------------------------------ mom-4_Cele ------------------------------------------------------------ TAK1_Mmus ------------------------------------------------------------ Y105C5A.24_Cele ------------------------------------------------------------ TAK1_Spur ------------------------------------------------------------ AqueK667_Aque --VWREEKS-EEILPVPTGLFPLTIVHLLNQKECVTKIS---PSTSEYYKFRDAISLKIT AqueK668_Aque --AWQIGNSGTKTLAIPQGLFPLTIVHLLEQRDYV-DFT---PVGKSYYRYYDAMSLHVY AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque PTKKS-------------------IVPPMPSQETT-SIKGSTK--------YS------- AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque --VWREEES-EEILPVPTGLFPLTIVHLLNQKDYVTKIS---PSTSEYYKFRDAISLRIT AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque --VDH-------------------EVHEMDNHETT-GYT-----------SLDE------ TAK1_Hsap -------------------------------MKV------QTE-IALLLQRKQELVA--- Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ----------------------------------ERLGKTVVREMAK---AAADGDR--- Tak1_Dmel -------------------------------LSV------DTN-LYYAQDFKDKLIV--- mom-4_Cele -------------------------------ADA------WVI-KKEVMRAKHELIA--- TAK1_Mmus -------------------------------MKV------QTE-IALLLQRKQELVA--- Y105C5A.24_Cele -------------------------------AEV------LLA-KKEAINEKHKLVQ--- TAK1_Spur -------------------------------LRV------QTE-LALLHTRKRALWS--- AqueK667_Aque FT-QKHTLHLINRYTHIEVYFTGPTQHCPLVRKL------LTTAIDDSSD-AMHLKHNYV AqueK668_Aque IEKKKYTIDIVNCYTHIKICFYDCKKACPQIRKL------VIEAIKRSSK-NLDVDDNHI AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque -KGPHMKLPAVKQYYHSE---------------GSAAAKSIVQA-----------VT--- AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque FT-QKHTLHLINRYTHIEVYFTGPTQHCPLVRKL------LTTAIDNSSD-AMHLKHNYV AqueK673_Aque -------------------------------FKI------LYE-MGQLDQKRIELDN--- AqueK674_Aque ---NRLRFDIQRQYLHIEQA---------------------------------------- TAK1_Hsap ----------------------------------EL------------------------ Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ----------------------------------EV------------------------ Tak1_Dmel ----------------------------------QM------------------------ mom-4_Cele ----------------------------------QW------------------------ TAK1_Mmus ----------------------------------EL------------------------ Y105C5A.24_Cele ----------------------------------KW------------------------ TAK1_Spur ----------------------------------FT------------------------ AqueK667_Aque NAFACPSKRNSCYCIVGFSKDVHFINCTVCCESA---TISNDH-WAWFE----------- AqueK668_Aque FAFKCAAD-EQCYCIVK--EDYSSTICTHCRSPCEVLESDDDSCRCWFS----------- AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque ----------------------------------KG------------------------ AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque NAFACPVKRNSCYCIVGFSKDGHFINCTMCSEPA---TISDDH-WNWYNIEGSIVSNKQE AqueK673_Aque ----------------------------------EL------------------------ AqueK674_Aque ------------------------------------------------------------ TAK1_Hsap ------------------------------------------------------------ Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel ------------------------------------------------------------ mom-4_Cele ------------------------------------------------------------ TAK1_Mmus ------------------------------------------------------------ Y105C5A.24_Cele ------------------------------------------------------------ TAK1_Spur ------------------------------------------------------------ AqueK667_Aque ------------------------------------------------------------ AqueK668_Aque ------------------------------------------------------------ AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque ------------------------------------------------------------ AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque NFLLIILDKKPQLDDLHRLFQSSDFQFLIIGTALGVQVNDLQHSPMSASDKLLLVFQRWI AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque ------------------------------------------------------------ TAK1_Hsap ------------------------------------------------------------ Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel ------------------------------------------------------------ mom-4_Cele ------------------------------------------------------------ TAK1_Mmus ------------------------------------------------------------ Y105C5A.24_Cele ------------------------------------------------------------ TAK1_Spur ------------------------------------------------------------ AqueK667_Aque ------------------------------------------------------------ AqueK668_Aque ------------------------------------------------------------ AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque ------------------------------------------------------------ AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque NSNMNITWRKALQVCEDYPDQFGLVKSDVIKFLSSDRAHDKYSDVIIYHLCIGPVESNNG AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque ------------------------------------------------------------ TAK1_Hsap ------------------------------------------------------------ Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel ------------------------------------------------------------ mom-4_Cele ------------------------------------------------------------ TAK1_Mmus ------------------------------------------------------------ Y105C5A.24_Cele ------------------------------------------------------------ TAK1_Spur ------------------------------------------------------------ AqueK667_Aque ------------------------------------------------------------ AqueK668_Aque ------------------------------------------------------------ AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque ------------------------------------------------------------ AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque TQIKQDNDQSSDEISASGITDDNIYGGTYVDTMPATITPAVRRLMKEATELREPFPHYYT AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque ------------------------------------------------------------ TAK1_Hsap ------------------------------------------------------------ Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel ------------------------------------------------------------ mom-4_Cele ------------------------------------------------------------ TAK1_Mmus ------------------------------------------------------------ Y105C5A.24_Cele ------------------------------------------------------------ TAK1_Spur ------------------------------------------------------------ AqueK667_Aque ------------------------------------------------------------ AqueK668_Aque ------------------------------------------------------------ AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque ------------------------------------------------------------ AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque QPMEDNLFEWHFTIQGPPGTDYEGGRYHGHIMISPEYPMKPPSVVFLTPNGRFKLNLEIC AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque ------------------------------------------------------------ TAK1_Hsap ------------------------------------------------------------ Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel ------------------------------------------------------------ mom-4_Cele ------------------------------------------------------------ TAK1_Mmus ------------------------------------------------------------ Y105C5A.24_Cele ------------------------------------------------------------ TAK1_Spur ------------------------------------------------------------ AqueK667_Aque ------------------------------------------------------------ AqueK668_Aque ------------------------------------------------------------ AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque ------------------------------------------------------------ AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque MCGLETWQSYWGISTVLLELIDMMATDDDRSTFGSLDCTPEERRQLATRSLEWVCPSCGV AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque ------------------------------------------------------------ TAK1_Hsap ------------------------------------------------------------ Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel ------------------------------------------------------------ mom-4_Cele ------------------------------------------------------------ TAK1_Mmus ------------------------------------------------------------ Y105C5A.24_Cele ------------------------------------------------------------ TAK1_Spur ------------------------------------------------------------ AqueK667_Aque ------------------------------------------------------------ AqueK668_Aque ------------------------------------------------------------ AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque ------------------------------------------------------------ AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque ANRTALPEGSEDIVSQMPKEEVNSQQPHDLDLQKEALLVAQFCPPSTDQSNQRNIDIKES AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque ------------------------------------------------------------ TAK1_Hsap ------------------------------------------------------------ Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel ------------------------------------------------------------ mom-4_Cele ------------------------------------------------------------ TAK1_Mmus ------------------------------------------------------------ Y105C5A.24_Cele ------------------------------------------------------------ TAK1_Spur ------------------------------------------------------------ AqueK667_Aque ------------------------------------------------------------ AqueK668_Aque ------------------------------------------------------------ AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque ------------------------------------------------------------ AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque HDQSKDEGGTEINKESSTSGIRYRGQEETDQPLSASPPPPSFPANIFKMAAVSPPHTQWG AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque ------------------------------------------------------------ TAK1_Hsap ------------------------------------------------------------ Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel ------------------------------------------------------------ mom-4_Cele ------------------------------------------------------------ TAK1_Mmus ------------------------------------------------------------ Y105C5A.24_Cele ------------------------------------------------------------ TAK1_Spur ------------------------------------------------------------ AqueK667_Aque ------------------------------------------------------------ AqueK668_Aque ------------------------------------------------------------ AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque ------------------------------------------------------------ AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque PGTTCIAKYNFLGSTPHDPNWFLARKVSDGQEGMVPFNYIKENIDEQEISSSSPVVETGS AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque -------------------------------NNNYPV-SL-------------------- TAK1_Hsap ------------------------------------------------------------ Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel ------------------------------------------------------------ mom-4_Cele ------------------------------------------------------------ TAK1_Mmus ------------------------------------------------------------ Y105C5A.24_Cele ------------------------------------------------------------ TAK1_Spur ------------------------------------------------------------ AqueK667_Aque ------------------------------------------------------------ AqueK668_Aque ------------------------------------------------------------ AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque ------------------------------------------------------------ AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque SQEQHKVKEAVELHAMPWFHGKMSRQEAENVLNPTKDGLFLVRESSFFAGDYILCVCYKG AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque ------------------------------------------------------------ TAK1_Hsap ------------------------------------------------------------ Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel ------------------------------------------------------------ mom-4_Cele ------------------------------------------------------------ TAK1_Mmus ------------------------------------------------------------ Y105C5A.24_Cele ------------------------------------------------------------ TAK1_Spur ------------------------------------------------------------ AqueK667_Aque ------------------------------------------------------------ AqueK668_Aque ------------------------------------------------------------ AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque ------------------------------------------------------------ AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque KVGHCRITRTDKNLVTLNGKEYFENLISLVEHHQKDAGGLPCTLKYSAEKKWNIGISDFK AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque ------------------------------------------------------------ TAK1_Hsap ------------------------------------------------------------ Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel ------------------------------------------------------------ mom-4_Cele ------------------------------------------------------------ TAK1_Mmus ------------------------------------------------------------ Y105C5A.24_Cele ------------------------------------------------------------ TAK1_Spur ------------------------------------------------------------ AqueK667_Aque ------------------------------------------------------------ AqueK668_Aque ------------------------------------------------------------ AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque ------------------------------------------------------------ AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque KHAVGKWMEEGSVDLTVTRVNMLGVPGAGKTCSLRLLLNEDPPTNDTSTPIACPAVRATR AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque ------------------------------------------------------------ TAK1_Hsap ------------------------------------------------------------ Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel ------------------------------------------------------------ mom-4_Cele ------------------------------------------------------------ TAK1_Mmus ------------------------------------------------------------ Y105C5A.24_Cele ------------------------------------------------------------ TAK1_Spur ------------------------------------------------------------ AqueK667_Aque ------------------------------------------------------------ AqueK668_Aque ------------------------------------------------------------ AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque ------------------------------------------------------------ AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque VAVSDKMIWNRVTPAKLLDKLAANLAAVAVNLEQEKIEEPPSSVVLSFPDNAQSSGEVSS AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque ------------------------------------------------------------ TAK1_Hsap ------------------------------------------------------------ Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel ------------------------------------------------------------ mom-4_Cele ------------------------------------------------------------ TAK1_Mmus ------------------------------------------------------------ Y105C5A.24_Cele ------------------------------------------------------------ TAK1_Spur ------------------------------------------------------------ AqueK667_Aque ------------------------------------------------------------ AqueK668_Aque ------------------------------------------------------------ AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque ------------------------------------------------------------ AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque DPSSTSSKENSPQYHDEAFIQEILEILATQPKEIHISDHWLYVIDSGGQPAYQELLPLFT AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque ------------------------------------------------------------ TAK1_Hsap ------------------------------------------------------------ Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel ------------------------------------------------------------ mom-4_Cele ------------------------------------------------------------ TAK1_Mmus ------------------------------------------------------------ Y105C5A.24_Cele ------------------------------------------------------------ TAK1_Spur ------------------------------------------------------------ AqueK667_Aque ------------------------------------------------------------ AqueK668_Aque ------------------------------------------------------------ AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque ------------------------------------------------------------ AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque RAASLNIIALDLSKPFNERFDLMYRIDGKYFPCHSKSTQLAFFQSAVSTGASFKPLDISC AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque ------------------------------------------------------------ TAK1_Hsap ------------------------------------------------------------ Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel ------------------------------------------------------------ mom-4_Cele ------------------------------------------------------------ TAK1_Mmus ------------------------------------------------------------ Y105C5A.24_Cele ------------------------------------------------------------ TAK1_Spur ------------------------------------------------------------ AqueK667_Aque ------------------------------------------------------------ AqueK668_Aque ------------------------------------------------------------ AqueK669_Aque ----------------------------EEILKSSMSSLESYLQNCVIHQSDDSIIFPIN AqueK670_Aque ------------------------------------------------------------ AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque ISKKPTHSMHLVLGTHYDKVSNATLKEKEEILMSSMSSLEPYLQECIIHQSDDYVIFPVN AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque ------------------------------------------------------------ TAK1_Hsap ------------------------------------------------------------ Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel ------------------------------------------------------------ mom-4_Cele ------------------------------------------------------------ TAK1_Mmus ------------------------------------------------------------ Y105C5A.24_Cele ------------------------------------------------------------ TAK1_Spur ------------------------------------------------------------ AqueK667_Aque ------------------------------------------------------------ AqueK668_Aque ------------------------------------------------------------ AqueK669_Aque TISASEERAKYSEEICKAIWLDGSAASLKIKIPIRWFAFELSLPDKQSIVSVKEALSIGE AqueK670_Aque ------------------------------------------------------------ AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque TVTTSEERAKYSEEICNAIWFDGSAASLEIKIPIRWFAFELSLPE-QSIVSVKEALSIGE AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque ------------------------------------------------------------ TAK1_Hsap ------------------------------------------------------------ Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel ------------------------------------------------------------ mom-4_Cele ------------------------------------------------------------ TAK1_Mmus ------------------------------------------------------------ Y105C5A.24_Cele ------------------------------------------------------------ TAK1_Spur ------------------------------------------------------------ AqueK667_Aque ------------------------------------------------------------ AqueK668_Aque ------------------------------------------------------------ AqueK669_Aque RYGMNEEDTKQALRYFHDVSLMLYYPQTQE------------------TLNYIARALNAV AqueK670_Aque ------------------------------------------------------------ AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque RYGMNEEDSKQALKYFHDVSLMLYYPEVTDIIFIDSKPIIEILSQLLALTYVDDRNARAL AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque ------------------------------------------------------------ TAK1_Hsap ------------------------------------------------------------ Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel ------------------------------------------------------------ mom-4_Cele ------------------------------------------------------------ TAK1_Mmus ------------------------------------------------------------ Y105C5A.24_Cele ------------------------------------------------------------ TAK1_Spur ------------------------------------------------------------ AqueK667_Aque ------------------------------------------------------------ AqueK668_Aque ------------------------------------------------------------ AqueK669_Aque N---IIGKAVQREPTYESIIGSFINGMKLKDNYYDIEEHCVKFLTALSGVGGPVAEASDM AqueK670_Aque ------------------------------------------------------------ AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque VLIKPLSRPIMNNLKEGFFNKNIFDHLKSRSV---------------------------- AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque ------------------------------------------------------------ TAK1_Hsap ------------------------------------------------------------ Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel ------------------------------------------------------------ mom-4_Cele ------------------------------------------------------------ TAK1_Mmus ------------------------------------------------------------ Y105C5A.24_Cele ------------------------------------------------------------ TAK1_Spur ------------------------------------------------------------ AqueK667_Aque ------------------------------------------------------------ AqueK668_Aque ------------------------------------------------------------ AqueK669_Aque IKKKWM------------------------------------------------------ AqueK670_Aque ------------------------------------------------------------ AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque -----VFSLPEFQLSDLIRLLLHLNIITELEDEPKGHYFIPYALPSYNEPVSIKETNAKP AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque ------------------------------------------------------------ TAK1_Hsap ------------------------------------------------------------ Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel ------------------------------------------------------------ mom-4_Cele ------------------------------------------------------------ TAK1_Mmus ------------------------------------------------------------ Y105C5A.24_Cele ------------------------------------------------------------ TAK1_Spur ------------------------------------------------------------ AqueK667_Aque ------------------------------------------------------------ AqueK668_Aque ------------------------------------------------------------ AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque ------------------------------------------------------------ AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque LLLVWREEESEEILPVPTGLFPLTIVHLLNQKEYITKISPSTPAYFKFRDAMSLKITFTQ AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque ------------------------------------------------------------ TAK1_Hsap ------------------------------------------------------------ Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ------------------------------------------------------------ Tak1_Dmel ------------------------------------------------------------ mom-4_Cele ------------------------------------------------------------ TAK1_Mmus ------------------------------------------------------------ Y105C5A.24_Cele ------------------------------------------------------------ TAK1_Spur ------------------------------------------------------------ AqueK667_Aque ------------------------------------------------------------ AqueK668_Aque ------------------------------------------------------------ AqueK669_Aque ------------------------------------------------------------ AqueK670_Aque ------------------------------------------------------------ AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque KHTLHLINRYTHIEVYFTGPTQHCPLVRKLLTTAIDNSSDAMHLKHNYINAFACPYNESC AqueK673_Aque ------------------------------------------------------------ AqueK674_Aque ------------------------------------------------------------ TAK1_Hsap ----------------------------------------------------DQDEKDQQ Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel ----------------------------------------------------RRAEKDTE Tak1_Dmel ----------------------------------------------------DRTEREQK mom-4_Cele ----------------------------------------------------PQHDHTVE TAK1_Mmus ----------------------------------------------------DQDEKDQQ Y105C5A.24_Cele ----------------------------------------------------AEHERTLE TAK1_Spur ----------------------------------------------------NVEGLSLT AqueK667_Aque ----------------------------------S----GPIVSRNATQTKQVKDHDT-S AqueK668_Aque ----------------------------------D-QISSPGVEASDAPSKRHGGQPTEL AqueK669_Aque -----------SICTTVGLNITFEGNA-------SKMDDMP-SAANAVQ---MKGHASDK AqueK670_Aque ----------------------------------------------------RNDEDDDS AqueK671_Aque ------------------------------------------------------------ AqueK672_Aque YCIVNEDHHKVADCTVCGESPALSNDYWTWFNDAQ----GPAESNNGTQIKQVNNQ-S-S AqueK673_Aque ----------------------------------------------------HGEELKST AqueK674_Aque --------------------------------------------PAHHQSRPKPTHSSY- TAK1_Hsap N---------------------------------------------------TSRLVQEH Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel RETSRA----AH----------------------------------------------NG Tak1_Dmel Q-------------E-------------------------------------LLRKMKDK mom-4_Cele -------------------------------------------------------LLER- TAK1_Mmus N---------------------------------------------------TSRLVQEH Y105C5A.24_Cele -------------------------------------------------------LLER- TAK1_Spur C---------------------------------------------------SDFRCRDN AqueK667_Aque D-QNLLLDKKPQKSDLLRLFKSSAAHYMIIGTALDV---KVDDLPP-YPGAATNNLILVF AqueK668_Aque D-TSHL----IDILDLLWDHGYSGVDYYFLGLRLGLLPRTLDVIKENNKDDVRGCLTKCL AqueK669_Aque T-TNLLLDKKPEKSDLLRLFKSSAAHYMIIGTAFDV---EVDDLSPHNPEATTINLIKVF AqueK670_Aque DEDTLF----FD------ASKSWNQ-F-------------------------------SK AqueK671_Aque ---------------------------------------------------------LEL AqueK672_Aque D-EN-IKDKEPKLKDLHRLFDSSAAHYLTIGTALEV---EVDDLLH-SPLSASDKLMAVF AqueK673_Aque K-STTS----FH------------------------------------------------ AqueK674_Aque ----------------SDT-------YS--RSNYQG---KLTPVPP-------------- TAK1_Hsap -------KK---------LLDENKSL-----STYYQQCKKQLEV---------------- Takl2_Dmel ------------------------------------------------------------ Takl1_Dmel -------ER----------------E-----TRRA-G--QDV------------------ Tak1_Dmel -------EG---------L------------QSLYNNLQQQYASRQLAAGHHPQPHPHPH mom-4_Cele -------KY---------YLEQ---------EIA--RY----RD---------------- TAK1_Mmus -------KK---------LLDENKSL-----STYYQQCKKQLEV---------------- Y105C5A.24_Cele -------IA---------CLEQ---------EIAYQEC----NN---------------- TAK1_Spur NSGECECIV---------VLQISCRL-----EIVDMFTLLQLQD---------------- AqueK667_Aque -------KR---------WIDSDNDVTWR---NILEVCEDYLED-----LGK-------- AqueK668_Aque -------TA---------WLEQRDNVKNRTYDALIQAL----RK-----MGE-------- AqueK669_Aque -------QK---------WLHSNNDVTWR---NIVQVCEDYPDE-----LGE-------- AqueK670_Aque -------SKVATGRGGDPLFDTGDRI-----EGKT-EGVSKI------------------ AqueK671_Aque -------KL---------GLRSNGNDAIG-----IVLCLFYASV---------------- AqueK672_Aque -------KR---------WIESNKGVTWR---NALQVCEDYPEK-----FGK-------- AqueK673_Aque -----------------------------RYSSILQEN---------------------- AqueK674_Aque ------------------------------------------------------------ TAK1_Hsap ------------------------------------IRS--QQQKRQGTS Takl2_Dmel ---------------------------------------------ARDRI Takl1_Dmel ------------------------------GRETVR-AV--KKIGKKLRF Tak1_Dmel PNQLQHPHSHPPMHFLQDEGCGLLPGSVCGGSES--VEEGWVVIPPHHNA mom-4_Cele ------------------------------------IQD--DNYFSTERM TAK1_Mmus ------------------------------------IRS--QQQKRQGTS Y105C5A.24_Cele ------------------------------------A-K--EKSSFSVRM TAK1_Spur ------------------------------------LIQ--RTNIFIDVS AqueK667_Aque ------V---------------------KADLKGF-LSS--DK-ARNKYL AqueK668_Aque -----KAV--------------------ADGIER--NSK--QMPLKNSLN AqueK669_Aque ------A---------------------KANVQKF-LLS--DRALAKYLK AqueK670_Aque ------------------------------ELERTKNRK--KRVFFKKNK AqueK671_Aque ------------------------------------YTE--TINENVIES AqueK672_Aque ------V---------------------KSDVEGF-LSS--NRACDNCEK AqueK673_Aque ---------------------------------R--ELE--EELKKLRSL AqueK674_Aque ------V---------------------KGDPESV------KMFEQFQKV