CLUSTAL W (1.83) multiple sequence alignment Wee1_Hsap MSFLSRQQPPP-PRR-AG---------AACTLR---------------------QKLIFS Wee1B_Hsap MDDKDIDKE----------------------LR---------------------QKLNFS DDB0220004_Ddis MDFPSQSEKKKYITKKRTTLFSYDDDDDDDDFDQNREFIHMSSYEESKDQQNSFNTLLLS wee_Dmel MAFRQSEHEMS-VTS-LD---------SSVELR---------------------S----- Wee1a_Spur MDGSYTENPAK-Q-----------------------------------------NKMTFT Wee1b_Spur MSLAAPMNSLF-HRG-V-----------HGSPS---------------------QRLDFG AqueK218_Aque MCTHAVVWG--------------------------------------------------- Wee1B_Mmus MADTETDQG----------------------LN---------------------KKLSFS Wee1_Mmus MSFLSRQQPPP-TRR-VG---------AAYSLR---------------------QKLIFS * Wee1_Hsap PCSDC-EEEEEE---------EEEEG-S-GHSTGEDS----------------------- Wee1B_Hsap YCEET-EIEGQK---------KVEESREASSQTPEKG----------------------- DDB0220004_Ddis ELSNC-EDQKQQ---------QQQQS---SSPTQSDCDSSPTNNNNNNNTNNNIVHHLNN wee_Dmel -----------------------RSP-SPQVFNPRKL----------------------- Wee1a_Spur CI---------------------------------------------------------- Wee1b_Spur DALGS-EGESDASFAAYSDFNEIQEG-AIDDHSPISS----------------------- AqueK218_Aque ------------------------------------------------------------ Wee1B_Mmus FCEEDTESEGQM---------TAQDIGGAQSQKPGRE----------------------- Wee1_Mmus PGSDC-EEEEEE----------EEEG-S-GHSTGEDS----------------------- Wee1_Hsap -------------------------------------------AFQE--PDS-----PLP Wee1B_Hsap -------------------------------------------EVQD--SEA-----KGT DDB0220004_Ddis SNSIPISGSNNNNNNNNNNNNNNNNNNNNNNNSHHHHLRKGRRLFHDDNDDQ-----PIY wee_Dmel -------------------------------------------RFADDDFDK-----DTP Wee1a_Spur ------------------------------------------------------------ Wee1b_Spur -------------------------------------------SFSDDRDDSLNLTAEWD AqueK218_Aque ------------------------------------------------------------ Wee1B_Mmus -------------------------------------------ESEE--LEG-----PVP Wee1_Mmus -------------------------------------------AFQE--PDS-----PLP Wee1_Hsap PARS----------------PTEPGPER-R--RSPGPAPGSPGELEEDLLLPGACPGAD- Wee1B_Hsap PPWT----------PLSNVHELDTSSEKDK--ESPDQILR-------------------- DDB0220004_Ddis PASASLSSTKTNMFPSSP--ILYSSPSSQQQQQQQQQ--QSQSQQTNEFKVPSFTPLSFI wee_Dmel EGAS----------PQ------HPLQQRPK--LSSGEEQ--------------------- Wee1a_Spur ------------------------------------------------------------ Wee1b_Spur PALA----------------TPKSSPSRRRVQRRPNSRLH---DGENS------------ AqueK218_Aque --NS----------LT------TPTSHRST--A----AM--------------------- Wee1B_Mmus PTRD----------------ELHTSLSRDK--ESPGPDLW-------------------- Wee1_Mmus SARS----------------PAEAEAERRR--RSPGAEPSSPGELEDDLLLQGGGGGAQ- Wee1_Hsap ---------------------------------------------EA-GGGAEGDSWEEE Wee1B_Hsap ------------------------------------------------------------ DDB0220004_Ddis NNSSTNSMNIRPINNNRIYNNLNNNNNNNNNNNNNINNINNNNINNINNNYNNNNNNEED wee_Dmel ------------------------------------------------------------ Wee1a_Spur ------------------------------------------------------------ Wee1b_Spur ------------------------------------------------------------ AqueK218_Aque ------------------------------------------------------------ Wee1B_Mmus ------------------------------------------------------------ Wee1_Mmus ---------------------------------------------AA-GGGAEGDSWEEE Wee1_Hsap GFGSSSPV-KSPAA----PYFLGSSFSPVRCGGPGD------------------------ Wee1B_Hsap -----TP---------VS--------HP-------------------------------- DDB0220004_Ddis QIFSSS----LPT-------------SPVSWSANGSMMNGHNINNITGNHSRFLSNGSYN wee_Dmel Q-------LDSK---------------IGKEGGDG------------------------- Wee1a_Spur ------------------------------------------------------------ Wee1b_Spur ---IASPHFRRPSDSSCSPSPMVCASSPASSAGGGD------------------------ AqueK218_Aque D-------YTSP---------------PSKC-IRF------------------------- Wee1B_Mmus -----KS---------VS--------GP-------------------------------- Wee1_Mmus GFGSSSPV-KSPST----AYFLSSPFSPVRCGGPGD------------------------ Wee1_Hsap ---A-----SPRGCGARRAGEG---RRSPRPDHPGTPPH-KTFRKLRLFDTPHTPKSLLS Wee1B_Hsap ------------------------------LKCPETPAQPDSRSKLLPSDSPSTPKTMLS DDB0220004_Ddis KGNTFPSTEVKRVRPDQRAFNENSFSMSPT---PSPPPT-PSLKR-NNYSS---PKFEPV wee_Dmel -------------------------------DVSMSPPC-QKVRALRLFSTPATPKTILQ Wee1a_Spur ------------------------------------------------------------ Wee1b_Spur ---A----------------------------VGSPPPH-KRLRNLKLFDSPHTPKSLIQ AqueK218_Aque -------------------------------NSPTNIINSTSSSKLRLFDTPHTPMTLLR Wee1B_Mmus ------------------------------PKCPETPVL-HSKSKLPVPTNFSTPKNSLG Wee1_Mmus ---A-----SPQGCGAPRAMDD---PCSPQPDYPSTPPH-KTFRKLRLFDTPHTPKSLLS Wee1_Hsap KARGIDSSSVKLRGSSLFMDTEKS-------------------------------GK--- Wee1B_Hsap RLVISPTGKLPSRGPKHLKLTPAP-------------------------------LK--- DDB0220004_Ddis FIRLAEERTNRKRSTSMTSNVNNNNN---------------NNANNNNVNNNNN-NN--- wee_Dmel KSTTQCSNHLSAAAAAVNASR------R----------------SDDLFRLSERPRSLPL Wee1a_Spur ---------------VLTL----------------------------------------- Wee1b_Spur KANAS-ARRNKLLASRLFSEKPASSTPTDHGDGPIAFGIARPHTAPNMRNLQRR-ST--- AqueK218_Aque RSSMS-ENDLNIQSDVMMTSSVPPPNNRPGGE---------SSIRPRISRLTLS---GPP Wee1B_Mmus QPEISLLEKLSSRSSRHMRLTPAS-------------------------------LM--- Wee1_Mmus KARVIDSGSVKLRGSSLFMDTEKS-------------------------------GK--- Wee1_Hsap REFDVRQTPQVNINPFTPDSL---LLHSSGQCRRR-KRTY-------------------- Wee1B_Hsap DE--MTSLALVNINPFTPESYKKLFLQSGGKRK---IRGD-------------------- DDB0220004_Ddis NGPNSISSLIANVNPFTEEGR---LQSLNKPCPSF-QLVNNN--NNNNNASNNNNDNNNN wee_Dmel HNRKLPTQDTANVNPFTPDSL---MAHNKKRCRTQFGRENLNLNV---NAM-----QKYL Wee1a_Spur ---DLKSWSYMYMYGFKPQ----------------------------------------- Wee1b_Spur RIPKTRQQNVANVNPFTPSAM---LQNATKKRLRQ-ERSI-------------------- AqueK218_Aque LRR--NTSKGTNINPFTPKDI---YTRSKRS-R--------------------------- Wee1B_Mmus DE--KTSLSLVNINPFTPETYRKLLLQSKGKRK---TRDY-------------------- Wee1_Mmus REFDTRQTPQVNINPFTPDPV---LLHSSGRCRGR-KRAY-------------------- : *. . Wee1_Hsap WNDSCGEDM-EA-SDYELEDETRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKC Wee1B_Hsap LEEA------GP--EEGK--GGLPAKRCVLRETNMASRYEKEFLEVEKIGVGEFGTVYKC DDB0220004_Ddis NNNN-NNN-NN-NNDDTCNNNNNNSQNIDNNLITKFSLYKHTFQELDLIGEGSFGHVYKV wee_Dmel LSDACDDDVTEEAGDSMREIHQQAPKRLALHDTNI-SRFKREFMQVNVIGVGEFGVVFQC Wee1a_Spur ----------------------------------------------C------------- Wee1b_Spur LDDD--EDL-DD--DMDGSYTENPAKRIALRDSDI-SRYEAEFVEVGKVGSGEFGSVYKC AqueK218_Aque ------EDT-ERACASEH--GGGKRKALALRESNI-YRYREEFHEVCIIGSGSFGVVYKC Wee1B_Mmus LEET------GE--EESKSVQWLPAKRSILQETNMASRYEKEFFEIEKIGVGEFGTVYKC Wee1_Mmus FNDS-SEDM-EA-SDYEFEDETRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKC Wee1_Hsap VKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVRYFSAWAEDDHMLIQN Wee1B_Hsap IKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGHHPHVVRYYSSWAEDDHMIIQN DDB0220004_Ddis RHRIDGCLYAIKKTKKPLKGQKDRDIVLREVYGLSAIKDHTNIVRYFNAWEEDSHIFIQM wee_Dmel VNRLDGCIYAIKKSKKPVAGSSFEKRALNEVWAHAVLGKHDNVVRYYSAWAEDDHMLIQN Wee1a_Spur ------------STGVPGQDTPFRQMALNEVYAHAVLGTHIHVVRYYSAWSEAGHMIIQN Wee1b_Spur INRLDGCFYAIKKSKRPIAGSAFEQMALNEVYAHAVLGTHIHVVRYYSAWSEAGHMIIQN AqueK218_Aque INRLDGCVYALKRSHKPVVGSADEPAALREVYAHAVLGSHPHLVRYYSAWAEDDHMLIQN Wee1B_Mmus IKRLDGCIYAIKRSAKSFSGLSNE-LDLHEVYAHAVLGHHPHVVRYYSSWIEDDHVVIQN Wee1_Mmus VKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHPHVVRYFSAWAEDDHMLIQN : . . *.**:. :.: * ::***:.:* * .*:.** Wee1_Hsap EYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISR Wee1B_Hsap EYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNYIHNSSMVHLDIKPSNIFICH DDB0220004_Ddis EHCNGGNIYKWVTEHIK----QSESNLLLLAKQILTGIVYIHSLGLVHLDIKPENIYIIY wee_Dmel EFCDGGSLHARIQDH-----CLGEAELKIVLMHVIEGLRYIHSNDLVHMDLKPENIFSTM Wee1a_Spur EYCNGGSLADIISSNKQNNHRMTEIELKQVLVQIAQGLKYIHSEGLVHMDIKP------- Wee1b_Spur EYCNGGSLADIISSNKQNNHRMTEIELKQVLVQIAQGLKYIHSEGLVHMDIKPGNIFISK AqueK218_Aque EYCNGGTLSSLISKIHKSTLRFNEVQLNRLIQHLAMGLTYIHSMGLVHLDIKPENVFISL Wee1B_Mmus EYCNGGSLQAAISENTASNNHFQEPKLKDILLQISLGLKYIHNSGMVHLDIKPSNIFICH Wee1_Mmus EYCNGGSLADAISENYRVMSYLTEVELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISR *.*:**.: : . * :* : :: *: ***. .:**:*:** Wee1_Hsap TSI-PNAA-------------S------------EEG-DEDDWA---------------- Wee1B_Hsap KMQS-ESS-----------G-V----------IEEVENEADWFL---------------- DDB0220004_Ddis KCNQ-NQIITNNNNTCSINNSSNGSDSYFKSKIKTTENDLDNFITTTNSVNNNNCNNNNN wee_Dmel NPN-AHKLVEVQPQQT---KDDD--------GMDSVY-EELRHS---------------- Wee1a_Spur ------------------------------------------------------------ Wee1b_Spur KEPLPSTT-PES---E---KIDE---------EEEEGATEDNTP---------------- AqueK218_Aque PTL-PDSRLPPQAEV-----------------------SWDSLL---------------- Wee1B_Mmus KMQC-DSP-----------V-G----------PEEAESEADWFL---------------- Wee1_Mmus TSI-PNAV-------------S------------EEG-DEDDWI---------------- Wee1_Hsap -----------------------SNKVMFKIGDLGHVTRISSPQV-EEGDSRFLANEVLQ Wee1B_Hsap -----------------------SANVMYKIGDLGHATSINKPKV-EEGDSRFLANEILQ DDB0220004_Ddis NNVDNQNNNNQNNYLIIDGNKINFNSITFKIGDLGLLNEATNTKIYSEGDSRYLSRELLH wee_Dmel -----------------------ENLVTYKIGDLGHVTSVKEPYV-EEGDCRYLPKEILH Wee1a_Spur -------------------------------GDLGHVTSISNPKV-EEGDVRFLPVEILQ Wee1b_Spur -----------------------LASLIYKIGDLGHVTSISNPKV-EEGDVRFLPVEILQ AqueK218_Aque -----------------------MSEALYKIGDMGHVTSVKSPQV-EDGDCRFISREVLQ Wee1B_Mmus -----------------------NASVMYKIGDLGHATSISKPKV-EEGDTRFLANEILQ Wee1_Mmus -----------------------SNKVMFKIGDLGHVTRISSPQV-EEGDSRFLANEVLQ **:* . ... : .:** *::. *:*: Wee1_Hsap ENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRI---------PQVLSQ Wee1B_Hsap EDYRHLPKADIFALGLTIAVAAGAESLPTNGAAWHHIRKGNFPDV---------PQELSE DDB0220004_Ddis DDMSALKKSDIFSLGCTLYELARCKPLPKSGMEWDSIRNGILSFEKEDSIYDDNKNDFST wee_Dmel EDYSNLFKADIFSLGITLFEAAGGGPLPKNGPEWHNLRDGKVPIL---------PS-LSR Wee1a_Spur EEHTHLTKADIFALALTAYLAAGGESLPKNGDDWHRIRQGHFPPL---------LH-IST Wee1b_Spur EVRS----KDAFHSHITMVIILG------------------------------------- AqueK218_Aque EDYSSLLESDVFSLGLTVYCAGSLCDLPKNGPEWHRIRDGHLPAL---------SQ-CSE Wee1B_Mmus ENYQHLPKADIFALGLTIAVAAGAESLPINGDMWHHIRKGNFPEI---------SQELSD Wee1_Mmus ENYSHLPKADIFALALTVVCAAGAEPLPRNGEQWHEIRQGRLPRI---------PQVLSQ : * * * Wee1_Hsap EFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKS-----AEQLRIELNAEKFKNSLLQ Wee1B_Hsap SFSSLLKNMIQPDAEQRPSAAALARNTVLRPSLGKT------EELQQQLNLEKFKTATLE DDB0220004_Ddis EFWQLIKSMIHPDPSVRPSAEQLLEHPLIKYGVIEIDDFENEIETLKNLLAEKEKVLIIQ wee_Dmel DFNELIAQMMHPYPDKRPTSQSIFSHPILSAVDSKS-----KLQLGLELTVEKRKNEILM Wee1a_Spur DLVDLLQTMIDPDPSQRPSASALVQHPLLCPNSKRS-----FTQLKRELNVAKFQNAILS Wee1b_Spur ------------------------------------------------------------ AqueK218_Aque HFNKLLLSLVHSSPSKRPTASELQSHPIVCPSTEKT-----KAQLMKELNEEKLKNQILT Wee1B_Mmus DFYGLLKNMIHPAPKERPSAAALARSRILWPFLEKT------DELQKQLNLEKSKTATLK Wee1_Mmus EVTELLRVMIHPDPERRPSAMELVKHSVLLSASRKS-----AEQLRIELNAEKFKNSLLQ Wee1_Hsap KELKKA------------------------------------------------------ Wee1B_Hsap RELREA------------------------------------------------------ DDB0220004_Ddis KEKQKLRQNQLQQKMQQPNFIELKQQPQQQQEKQQMLHQQKQQYLEQHNNNNDNNNNEFD wee_Dmel NKLREA------------------------------------------------------ Wee1a_Spur RELNEA------------------------------------------------------ Wee1b_Spur ------------------------------------------------------------ AqueK218_Aque RELRDL------------------------------------------------------ Wee1B_Mmus RELKKA------------------------------------------------------ Wee1_Mmus KELKKA------------------------------------------------------ Wee1_Hsap -------------------------QMAKA-AAEERALFTDRMATRSTTQSNRTSRLIGK Wee1B_Hsap -------------------------QQAQS-PQGYTH-HGDTGVSGTHTGSRSTKRLVGG DDB0220004_Ddis ESEKEYQIQLEQFKIQKMQFQLQQEQLQYQHQHKHQNFFT-------------------- wee_Dmel -------------------------KKQIKLLEQRVNLL---AV----T--NNPD-SLD- Wee1a_Spur -------------------------RKSTMNPP-------------PKSR-SNAGRLIGK Wee1b_Spur ------------------------------------------------------------ AqueK218_Aque -------------------------REFSKSKRK-NKY------------------LIGG Wee1B_Mmus -------------------------RHIQT-PQREVH-HCYYQI---CKGSR--HLLVGG Wee1_Mmus -------------------------QMAAKVAAEERALFTDRMATRSTTQSNRTSRLIGK Wee1_Hsap --KMNRSVS------------------------LTIY Wee1B_Hsap --KSARSSS------------------FTSGEREPLH DDB0220004_Ddis ---------KQICTASQIEGGI----------KNMAL wee_Dmel GQRCLRSFTRRMRTPFSSHGKFDSISDRNKN-VITNI Wee1a_Spur --KVNRSMS------------------------LTIY Wee1b_Spur --------I------------------------MIVM AqueK218_Aque GARGCRSM----------------------S-ADAFY Wee1B_Mmus --RRKAPSS------------------FTRG--TSSV Wee1_Mmus --KMNRSVS------------------------LTIY