CLUSTAL W (1.83) multiple sequence alignment MST4_Hsap MAHSPVAV---------------------------------------------------- MST3_Hsap MDSRAQLWGLALNK---------------------------------------------- MST4_Mmus MAHSPVAV---------------------------------------------------- MST3_Mmus MESKVPRLGLALKR---------------------------------------------- gck-1_Cele MTTTSSDE-LPRQA---------------------------------------------- SPS1_Scer MESKEIS----------------------------------------------------- KIC1_Scer MTTKPQNS---------------------------------------------------- CG5169_Dmel MSWT-------------------------------------------------------- YSK1_Mmus MAHLRGF----------------------------------------------------- YSK1_Hsap MAHLRGF----------------------------------------------------- SvkA_Ddis MASK-------------------------------------------------------- 17911_Tthe ------------------------------------------------------------ YSK_Spur MAM--------------------------------------------------------- CC1G_11537_Ccin MSQ--------------------------------------------------------- CC1G_00304_Ccin MTLTWSST-RSPPPSPKV------------------------------------------ CC1G_13722_Ccin MDSR-------------------------------------------------------- AqueK239_Aque MKRYSMKT-LQVAKGGGSIY-KHNIPYL-------------------------AGQTLE- AqueK240_Aque MATP-------------------------------------------------------- AqueK241_Aque ------------------------------------------------------------ AqueK242_Aque MATAKSGD-LCVGV---------------------------------------------- YSK_Smoe MSNVGAAT-AAATAGTSS------------------------------------------ GK082_Glam MEKKPVFL-LFGILRDQDLTLTTLLPFVICKTVYLCSDAEVVLFIWTTFGYFLGRFACHQ MST4_Hsap ------QVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAED MST3_Hsap RRATLPHPGGSTNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAED MST4_Mmus ------QVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAED MST3_Mmus RKATPLHPGGKENLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAED gck-1_Cele DDDSM-KWDRIYIQKLDPEVIFTKQERIGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAED SPS1_Scer -----------IRSRTPPSKLYSIQSCIGRGNFGDVYKAVDRVTQEIVAIKVVNLEHSDE KIC1_Scer ------K-QGLAEGEMDVSSLFKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSD CG5169_Dmel -------------EKVDPELIFTKQERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAED YSK1_Mmus ---------AHQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAED YSK1_Hsap ---------ANQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAED SvkA_Ddis --------------KGDPEELYVRQEKIGKGSFGEVFKGINKKTNETIAIKTIDLEDAED 17911_Tthe ------------------------------------------------------------ YSK_Spur ------------------------------------------------------------ CC1G_11537_Ccin ---------------PDVHQLYQRLETIGKGAYGSVHKGKHIPTGNVVALKIINLDTPDD CC1G_00304_Ccin EQRTRPRD-PCPIPSSNPASQYTLLEKLGTGSFGVVYKAIHNETKQIVAIKQIDLEDSDD CC1G_13722_Ccin --------------QQDPEEFYVKQDRIGKGSFGEVYKGYDKRTQKTVAIKIIDLESAED AqueK239_Aque TKDIPTLMATPLGKSGDPEVLFTRLKKIGKGSLGEVFKGIDIKSKEVLSFKIIELEEPEV AqueK240_Aque -----------LGKSADPEVLFTRLEKIGKGSFGEVFKGIDNQNKEVLAFKIIDLEEAED AqueK241_Aque ------------------------------------------------------------ AqueK242_Aque GP----SSGSSGGGTTDPEGLFTKQEKIGSGNFGEVFKGVENRSNRVVAIKIIDLENADD YSK_Smoe SSSAAAAAAVAAAAAAGIDSRFDNLQLIGKGSFGDVFKGFDKELNKEVAIKVIDLEEAED GK082_Glam LRVFSLSNFTLLAKFVNNPMGYKLLKILGSGGFGSVYLALDEKTMTYVAIKTVDLEQSLS MST4_Hsap EIEDIQQEITVLSQC-DSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA---G-PFD MST3_Hsap EIEDIQQEITVLSQC-DSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEP---G-PLD MST4_Mmus EIEDIQQEITVLSQC-DSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA---G-PFD MST3_Mmus EIEDIQQEITVLSQC-DSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEP---G-PLD gck-1_Cele EIEDIQQEIQVLSQC-DSQYVTKYFGSFLKGSKLWIIMEYLGGGSALDLTKS---G-KLD SPS1_Scer DIELLAQEIFFLAEL-KSPLITNYIATMLEDVSMWIVMEYCGGGSCSDLLKRSYVN-GLP KIC1_Scer EVEDVQREIQFLASLKQISNITRYYGSYLKDTSLWIIMEHCAGGSLRSLLRP---G-KID CG5169_Dmel EIDDIQQEIMVLSQC-DSPYVTKYYGSFLKGTKLWIIMEYLGGGSALDLMKA---G-SFE YSK1_Mmus EIEDIQQEITVLSQC-DSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKP---G-PLE YSK1_Hsap EIEDIQQEITVLSQC-DSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKP---G-PLE SvkA_Ddis EIEDIQQEINVLSQC-ESPFVTKYFGSFLKGSKLWIIMEYLAGGSVLDLMKP---G-PFD 17911_Tthe -------------------------------------MEYCGGGSLAQLIKK--KG-QFQ YSK_Spur -----------------------TLGATMQGTKLWIIMEYLGGGSALDLLKS---G-AMD CC1G_11537_Ccin DVADIQREVALLTQLRDAPNITKYFGCYMDGPRVWIVMEYAQGGSVLTLMKASKDG-CIE CC1G_00304_Ccin DISEIQQEIASLAQC-DSEYVTKYYGSFVVHYKLWIVMEYLAGGSCLDLLKA---G-PFS CC1G_13722_Ccin EIEDIQQEIQILSQL-DSPHVTKYHGSYLKGSHLWIVMEYCSGGSCSDLMKP---G-VFR AqueK239_Aque EIDDIPREISVQPEC-DSPYIAKYYGSYVKETKLWIVMEYLGGGSALDLMQP---G-PVE AqueK240_Aque EIEDIQQEITILSQC-DSAHVTRYYGSYLxxxxxxxxxxxxxxxxxxxxxxx---x-xxx AqueK241_Aque ------------------------------------------------------------ AqueK242_Aque EIEDVQQEITVLSQC-DSLYVTRYFGSYLKGTKLWIVMEYLGGGSARDLMQP---G-PLE YSK_Smoe EIDEIQKEISVLSQC-RSPYITEYYGSFLHGTKLWIVMEYMAGGSVSDLLET---GNPLD GK082_Glam ELDVVQKEVTLMTRL-MSNYTIRYYRSWCTESTLNIAMEA-GLCSVADILSI--VG-PLN MST4_Hsap EFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQG--------------------- MST3_Hsap ETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHG--------------------- MST4_Mmus EFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQG--------------------- MST3_Mmus EIQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHG--------------------- gck-1_Cele ESHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEHG--------------------- SPS1_Scer EEKVSFIIHEVTLGLKYLHEQRKIHRDIKAANILLNEEG--------------------- KIC1_Scer EKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEG--------------------- CG5169_Dmel EMHIGIILREVLKGLDYLHSERKLHRDIKAANVLLSEQG--------------------- YSK1_Mmus ETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQG--------------------- YSK1_Hsap ETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQG--------------------- SvkA_Ddis EGYIAIILRELLKGLEYLHSEGKIHRDIKAANVLLSASG--------------------- 17911_Tthe EPYITIILKEILQALSYLHSNQMVHRDIKSANILIQKDG--------------------- YSK_Spur EIYIATILREVIKGLDYLHCERKIHRDIKAANVLLSENG--------------------- CC1G_11537_Ccin EKYTSVIIREVLVALSYLHKVPVIHRDLKAANILVTATG--------------------- CC1G_00304_Ccin EAHIAVICRELLLGLDYLHAEGTIHRDIKAANVLLSSSG--------------------- CC1G_13722_Ccin EEYIAIIIRELLRGLEYLHTEGKLHRDIKAANILLSANG--------------------- AqueK239_Aque EVYIATILREVLHGLDYLHTQGKLHRDIKASNVLFSTTG--------------------- AqueK240_Aque xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--------------------- AqueK241_Aque ------------------------------------------------------------ AqueK242_Aque ETQIATILREVLKGLEYLHTEKKLHRDIKAANILLSDRG--------------------- YSK_Smoe ELSIACIIRDLLHALDYLHSEGKIHRDIKAANILLTANG--------------------- GK082_Glam EATACFIMYHLVKGVAYLHESKVIHRDLKCANILVTDDSTSSTVAQQPDGLAKRLIDLIL MST4_Hsap --------------------------------------------DVKLADFGVAGQLTDT MST3_Hsap --------------------------------------------EVKLADFGVAGQLTDT MST4_Mmus --------------------------------------------DVKLADFGVAGQLTDT MST3_Mmus --------------------------------------------EVKLADFGVAGQLTDT gck-1_Cele --------------------------------------------DVKVADFGVAGQLTET SPS1_Scer --------------------------------------------MVKLGDFGVSGHIRST KIC1_Scer --------------------------------------------NVKLCDFGVAAQVNQT CG5169_Dmel --------------------------------------------DVKLADFGVAGQLTNT YSK1_Mmus --------------------------------------------DVKLADFGVAGQLTDT YSK1_Hsap --------------------------------------------DVKLADFGVAGQLTDT SvkA_Ddis --------------------------------------------DVKLADFGVSGQLTDQ 17911_Tthe --------------------------------------------KVKLCDFGVSSKITNN YSK_Spur --------------------------------------------DVKLADFGVAGQLTET CC1G_11537_Ccin --------------------------------------------KVMICDFGVSALLTTV CC1G_00304_Ccin --------------------------------------------KVKLADFGVAAQLTNT CC1G_13722_Ccin --------------------------------------------EVKLADFGVSGQLSGT AqueK239_Aque --------------------------------------------QVKLTDFGVAGQLTDT AqueK240_Aque --------------------------------------------xxxxxxxxxxxxxxxx AqueK241_Aque ------------------------------------------------------------ AqueK242_Aque --------------------------------------------EVKLADFGVAGQLTDT YSK_Smoe --------------------------------------------DVKVADFGVSAQLTRT GK082_Glam GKPVSPGLFSETSRPRSSHGSYISTIARSFSPRPNSDSAAALSLGIKLCDFGVSTTISST MST4_Hsap Q-IKRNTFVGTPFWMAPEVIQ--QS-AYDSKADIWSLGITAIELAKGEPPNSDMHPMRVL MST3_Hsap Q-IKRNTFVGTPFWMAPEVIK--QS-AYDSKADIWSLGITAIELARGEPPHSELHPMKVL MST4_Mmus Q-IKRNTFVGTPFWMAPEVIQ--QS-AYDSKADIWSLGITAIELAKGEPPNSDMHPMRVL MST3_Mmus Q-IKRNTFVGTPFWMAPEVIK--QS-AYDSKADIWSLGITAIELAKGEPPHSELHPMKVL gck-1_Cele V-KKRITFVGSPFWMAPELIK--QS-SYDYKADIWSLGITAIELANGEPPHSDLHPMRVL SPS1_Scer --LKRDTFVGTPYWMAPEVVCCEVD-GYNEKADIWSLGITTYELLKGLPPLSKYDPMKVM KIC1_Scer S-LRRQTMAGTPYWMAPEVIM--EGVYYDTKVDIWSLGITTYEIATGNPPYCDVEALRAM CG5169_Dmel T-SKRNTFVGTPFWMAPEVIK--QS-QYDAKADIWSLGITAIELAKGEPPNSELHPMRVL YSK1_Mmus Q-IKRNTFVGTPFWMAPEVIK--QS-AYDFKADIWSLGITAIELAKGEPPNSDLHPMRVL YSK1_Hsap Q-IKRNTFVGTPFWMAPEVIK--QS-AYDFKADIWSLGITAIELAKGEPPNSDLHPMRVL SvkA_Ddis M-TKRNTFVGTPFWMAPEVIK--QT-GYDSKADIWSMGITALEMAKGEPPRADLHPMRAL 17911_Tthe S-QKLQTFVGTPYYMAPEVIQ--KS-EYDFKADIWSVGITAIEMATGHPPYYDKKPEIAM YSK_Spur Q-IKRNTFVGTPFWMAPEVIK--QS-AYDSKADMWSLGITAIELAKGEPPNSDLHPMRVL CC1G_11537_Ccin S-SKRTTLTGTPYWMAPEVIQ--GVSAYDTKADIWSLGIMIFEMIKGTPPHSNLDKFKVM CC1G_00304_Ccin L---RHTFVGTPFWMAPEVIR--QA-GYDSKADMWSLGITAIEMAKGEPPLAEYHPMRVL CC1G_13722_Ccin LSAKKNTFVGTPYWMSPEVIK--QS-GYDHKADIWSLGITAIELAKGEPPYAELHPMKVL AqueK239_Aque M-NKRNTIVERPFWMAPEVIT--RT-VYDTKADIWSLGITAIELAQGQPPHADLHPIRAL AqueK240_Aque x-xxxxxxxxxxxxxxxxxxx--xx-xxxxKADVWSLGITAIELAQGQPPHADLHPMRVL AqueK241_Aque -------------------------------ADVWSLGITAIELAQGQPPHADLHPMRVL AqueK242_Aque M--KKFTFVGTPFWMAPEVIR--QS-AYDMKADIWSLGITAIELARGEPPNSDLHPMRVL YSK_Smoe V-SKRKTFVGTPFWMAPEVIQ--NSDGYNEKADIWSLGITTIEMAKGEPPFADLHPMRVL GK082_Glam M-SKRCSFVGTPYWLSPEAIT--KN-ECDSFSDIWAVGICLYELIFGHPPHHKLSPTKAM *:*::** *: * ** . .: MST4_Hsap FLIPKNNPPTLVGD----FTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSK--KTS MST3_Hsap FLIPKNNPPTLEGN----YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAK--KTS MST4_Mmus FLIPKNNPPTLIGD----FTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSK--KTS MST3_Mmus FLIPKNNPPTLEGN----YSKPLKEFVEACLNKEPSFRPTAKELLKHKFIIRNAK--KTS gck-1_Cele FLIPKNPPPVLQGS---QWSKPFKEFVEMCLNKDPENRPSASTLLKHQFI-KRAK--KNS SPS1_Scer TNLPKRKPPKLQGP----FSDAAKDFVAGCLVKTPADRPSAYNLLSFEFV-KNIT--ITN KIC1_Scer QLIIKSKPPRLEDR---SYSTSLKEFIALCLDEDPKERLSADDLLKSKFI-RAHKATPTS CG5169_Dmel FLIPKNNPPQLTGS----YTKSFKDFVEACLNKDPENRPTAKELLKYPFI-KKAK--KNA YSK1_Mmus FLIPKNNPPTLEGH----HSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTK--KTS YSK1_Hsap FLIPKNSPPTLEGQ----HSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTK--KTS SvkA_Ddis FLIPKDPPPTLEGN----FSKGFKEFCALCLNKDPNQRPTAKDLLKHKFI-KAAK--KTS 17911_Tthe SRIVSEEPPSLSKE---TSSTMLINFVNCCLKYNPEQRQSAKQLLSHSFI-KLAK--KPS YSK_Spur FLIPKNNPPKLEGS----YTKNFKDFVEVCLNKDPRHRPTAKELLKHRFI-KQAK--RTS CC1G_11537_Ccin DLIPRAKPPRLQES---EGSKDMRDFMSYCLKESPTERLPAEELLKTKWI-KSISKVNVS CC1G_00304_Ccin FLIPKAKPPTLEGP----FSAAFKDFVTLCLTKDPKLRPSANELLQHRFI-RGAK--KTS CC1G_13722_Ccin FLIPKNPPPTLEGN----FSKTFREFVSYCLQRDPKERPSAKELLKHKFV-RMAK--KTS AqueK239_Aque FLIPKSNPPELLGN----YSESFKEFIAICLNKDPNNRPSARDLLHHKFM-KYAK--NTS AqueK240_Aque FLIPKSNPPELLGN----YSKSFKEFIALCLNKDPKNRPSARDLLRHKFI-KHAK--KTS AqueK241_Aque FLIPK---PELLGN----YSKSFKEFIALCLNKDPKNRPSARELLRHKFI-KHAK--KTS AqueK242_Aque FLIPKNSPPELTGN----FSKPFKEFVATCLNKDPSHRPTARELLKHRFL-KQAR--KTS YSK_Smoe FLIPKNNPPQLEDH----FSRPMKEFVSLCLKKNPAERASAKELLKHRFV-RNAR--KSP GK082_Glam IEIARNSSSTSLFDDKVEISKTCRDFAACCLDRDKTNRWPASKLLTHKWF-KTIQ--KVS : . : :* ** * .* ** :. : MST4_Hsap Y---LTELIDRFKRWKA---E-GHSDD--------------------------------- MST3_Hsap Y---LTELIDRYKRWKA---E-QSHD---------------------------------- MST4_Mmus Y---LTELIDRFKRWKA---E-GHSDE--------------------------------- MST3_Mmus Y---LTELIDRYKRWKA---E-QSHE---------------------------------- gck-1_Cele I---LVDLIERAAEYRL---R-TGVSS--------------------------------- SPS1_Scer L-KSDVDLIKQ---KKV---Q-ERYTK--------------------------------- KIC1_Scer I---LKELISRYLLFRD---K-NKN----------------------------------- CG5169_Dmel Y---LIDLIDRFKKWKV---S-KGDES--------------------------------- YSK1_Mmus F---LTELIDRYKRWKS---E-GHGE---------------------------------- YSK1_Hsap F---LTELIDRYKRWKS---E-GHGE---------------------------------- SvkA_Ddis S---LTDLIERRQKWLQ---L-NGNNA--------------------------------- 17911_Tthe Y---LIDLFDIDLKRGNFLFKPGAPNQQIRANSMVTGSAILIPNNKPQGGKTADSELLIQ YSK_Spur Y---LTELIERYKRWKA---E-GNDSP--------------------------------- CC1G_11537_Ccin I---LKDLILRLQQTGP---R-ASLAGP----------------L--------------- CC1G_00304_Ccin Y---LTELIERYQEWRM---R-SPHKG--------------------------------- CC1G_13722_Ccin Y---LTELIERHERWKA---E-GGDRG--------------------------------- AqueK239_Aque C---LVDLIERYKRWKA---S-GENS---------------------------------- AqueK240_Aque C---LVDLIDRYKRWKA---S-GENS---------------------------------- AqueK241_Aque C---LVDLIDRYKRWKA---S-GENS---------------------------------- AqueK242_Aque Y---LVDLIDRYKRWKA---N-GGEDG--------------------------------- YSK_Smoe R---LLERIRERPKVHI---R-KPRSE--------------------------------- GK082_Glam ARDVLAPIMEKYFRDFN---R-REQDRL----------------HDPFAIQTKQDDL--- : MST4_Hsap --------------------------------E--SD-SEGSDSE--------------- MST3_Hsap --------------------------------D--SS-SEDSDAE--------------- MST4_Mmus --------------------------------E--SD-SEGSDSE--------------- MST3_Mmus --------------------------------D--SS-SEDSDVE--------------- gck-1_Cele --------------------------------D--SD----------------------- SPS1_Scer --------------------------------V--PKYPLQNRLY--------------- KIC1_Scer ----------------------KYKIEGSIP-EN-EP-SKPSEAPK-PSQNGGGDEAQKS CG5169_Dmel --------------------------------E--TE-SENSDSD--------------- YSK1_Mmus --------------------------------E--SS-SEDSDID--------------- YSK1_Hsap --------------------------------E--SS-SEDSDID--------------- SvkA_Ddis --------------------------------D--D---ENDDLD--------------- 17911_Tthe STMKQITMEQRLEEQKDLKEFSNYLNSGNNPIDDK------C------------------ YSK_Spur --------------------------------D--SD-PEDNEFP--------------- CC1G_11537_Ccin ----------------------DWELEEE------------------------------- CC1G_00304_Ccin --------------------------------Q--N--NAATIRN--------------- CC1G_13722_Ccin --------------------------------M--E---EDDRPR--------------- AqueK239_Aque --------------------------------D--SN-PEDTSIS--------------- AqueK240_Aque --------------------------------D--SD-SEDTSRS--------------- AqueK241_Aque --------------------------------D--SD-SEDTSRS--------------- AqueK242_Aque --------------------------------T--PT-KRKSVQS--------------- YSK_Smoe --------------------------------H--MY--EQDTVE--------------- GK082_Glam ---------------G-----YIWLPEEQGSAEEEFV-PVKQAAASRARANAGSEINV-T MST4_Hsap ----------S--TSR---E-NN----------TH-PEWSFT-TVRKK------------ MST3_Hsap ----------T--DGQ-ASG-GS----------DS-GDWIF--TIREK------------ MST4_Mmus ----------S--SSR---E-SN----------PH-PEWSFT-TVRKK------------ MST3_Mmus ----------T--DGQ-ASG-GS----------DS-GDWIF--TIREK------------ gck-1_Cele ----------L--DED-SDG-GG----------GT-SKWDYP-TVRGPRVS-ADD----- SPS1_Scer --------------KN-SN-TVR----------GK-EFWNFE-STRLST----------- KIC1_Scer IASND-----N--EIK-RVNEGD----------VE-MKWDFD-SLSSSDYII--ENNINL CG5169_Dmel ----------S--DAK-QGG-SS----------QD-EPWIM--TVKGLHIN-SAP----- YSK1_Mmus ----------G--E---AED-GE----------QG-PIWTFPPTIRPS------------ YSK1_Hsap ----------G--E---AED-GE----------QG-PIWTFPPTIRPS------------ SvkA_Ddis ----------R--D---AKS-NE----------ED-FGWEFP-TIKQKSPV-A------- 17911_Tthe -KNMDQIVIDI--Y-R-GDKHKQ----------DKEKKKQVQ-SNKQSNQPT-------- YSK_Spur ----------N--ESL---Q-NN-----------L-PDFDYGNTIRG------------- CC1G_11537_Ccin -------------------ADQN----------AQ-QDWEFD-TVRFDRRPSLDEEDYNA CC1G_00304_Ccin ----------T--ATW-DM-NDT----------IR-SDWNFD-TVKSMGAMG-TF----- CC1G_13722_Ccin ----------G--DPD-AGANGD----------PD-DMWDFG-TVRHAGRT-L-G----- AqueK239_Aque ----------K--VHR-GDDD--------------------------------------- AqueK240_Aque ----------K--VHR-GDDDTT----------DP-PDWKFD-TVRETSTSE-AP----- AqueK241_Aque ----------K--VHR-GDDEAT----------DP-PDWKFD-TVRETSASE-AP----- AqueK242_Aque ----------I--DSQ-EDNDSG----------LD-DIWDFS-VDSPSDKTGTIK----- YSK_Smoe ----------KPKGLKAAKD-GESHLLSLTKAMRN-ASWDFG-TGTIQGIS-Q-G----- GK082_Glam FSPEDPYLNQL--DHE-KIQPTK----------KQ-EDWSFS-SDTSENSPQ-------- MST4_Hsap ------------------------------------------------------------ MST3_Hsap ------------------------------------------------------------ MST4_Mmus ------------------------------------------------------------ MST3_Mmus ------------------------------------------------------------ gck-1_Cele ---------------------------------------------------DGTVR---- SPS1_Scer ------------------------------------------------------------ KIC1_Scer DALAEDNNEWATAQHDLFNYAYPDEDSYYFDPTSHNTRPFVYQGTTIGKGYPGTIAQNST CG5169_Dmel ---------------------------------------------------RAGVNSFQL YSK1_Mmus ------------------------------------------------------------ YSK1_Hsap ------------------------------------------------------------ SvkA_Ddis ------------------------------------------------------------ 17911_Tthe ------------------------------------------------------------ YSK_Spur ------------------------------------------------------------ CC1G_11537_Ccin PSQ--ATPTD-------------------------------------S---FETVRVPAS CC1G_00304_Ccin ---------------------------------------------------RGSVK---- CC1G_13722_Ccin ---------------------------------------------------RGSVR---- AqueK239_Aque ------------------------------------------------------------ AqueK240_Aque ------------------------------------------------------------ AqueK241_Aque ------------------------------------------------------------ AqueK242_Aque ---------------------------------------------------RGSTS---- YSK_Smoe ---------------------------------------------------TGTVR---- GK082_Glam ------------------------------------------------------------ MST4_Hsap ------------------------------------------------------------ MST3_Hsap ------------------------------------------------------------ MST4_Mmus ------------------------------------------------------------ MST3_Mmus ------------------------------------------------------------ gck-1_Cele -Q-------------------------------------------R-------------- SPS1_Scer ------------------------------------------------------------ KIC1_Scer L---NAPVT---------NNYTNSK-----------YPSKMVAGTTNTSGTHTAGPMTSS CG5169_Dmel QE-------------------------------------------H-------------- YSK1_Mmus ------------------------------------------------------------ YSK1_Hsap ------------------------------------------------------------ SvkA_Ddis ---------------------------------------VQEQQQT-------------- 17911_Tthe ------------------------------------------------------------ YSK_Spur ------------------------------------------------------------ CC1G_11537_Ccin A----------------------------------------------------------- CC1G_00304_Ccin -DL-GM------------------------------------------------------ CC1G_13722_Ccin -VA-GPPLTWENDGRNRMDDYSESRYK--RSLNNSEDSYSSSITAK-------------- AqueK239_Aque ------------------------------------------------------------ AqueK240_Aque ------------------------------------------------------------ AqueK241_Aque ------------------------------------------------------------ AqueK242_Aque -S-------------------------------------------T-------------- YSK_Smoe -SGLRTPFGFDDRVESFEGDMSPRISSRSHDWHRTSASSSTEQQAA-------------- GK082_Glam ------------------------------------------------------------ MST4_Hsap ------------------------------------------------------------ MST3_Hsap ------------------------------------------------------------ MST4_Mmus ------------------------------------------------------------ MST3_Mmus ------------------------------------------------------------ gck-1_Cele ----T-------------------------DRPR----AQVDR--RSPSGSPGGTIVRGS SPS1_Scer ------------------------------------------------------------ KIC1_Scer KRLES-------------------------KAPKQLLEL--------------------- CG5169_Dmel ----E-------------------------LTMQ-----KLMQTTHSPA---GGGGVQAS YSK1_Mmus ------------------------------------------------------------ YSK1_Hsap ------------------------------------------------------------ SvkA_Ddis ----P-------------------------QKPT-------------------------- 17911_Tthe ------------------QST--------------------------------------- YSK_Spur ------------------------------------------------------------ CC1G_11537_Ccin K-----------------------------TLPSSLRHL--------------------- CC1G_00304_Ccin ----PTGMILEADESDDGETSIDTGAATKGSDPL----L--------------------- CC1G_13722_Ccin ----N-------------------------ELP--------------------------- AqueK239_Aque ------------------------------------------------------------ AqueK240_Aque ---------------------------------R----L--------------------- AqueK241_Aque ---------------------------------R----L--------------------- AqueK242_Aque ----D-------------------------SSPS-------------------------- YSK_Smoe ----A-------------------------QEP--------------------------- GK082_Glam ------------------HSK--------------------------------------- MST4_Hsap ------------------------------------------------------------ MST3_Hsap ------------------------------------------------------------ MST4_Mmus ------------------------------------------------------------ MST3_Mmus ------------------------------------------------------------ gck-1_Cele PQVAAVAEQLRNSSVGSSGYGS-GGNSASSQYATSSLPQSHT----A------------S SPS1_Scer ------------------------------------------------------------ KIC1_Scer ------------------------------------------------------------ CG5169_Dmel PAANALSSSVSAVAASASS-VSVITANEGV-SSASALPPQNSHVHNHNHNNINNNNIRNL YSK1_Mmus ------------------------------------------------------------ YSK1_Hsap ------------------------------------------------------------ SvkA_Ddis ------------------------------------------------------------ 17911_Tthe ------------------------------------------FF---------------- YSK_Spur ------------------------------------------------------------ CC1G_11537_Ccin ------------------------------------------------------------ CC1G_00304_Ccin ------------------------------------------------------------ CC1G_13722_Ccin ------------------------------------------------------------ AqueK239_Aque ------------------------------------------------------------ AqueK240_Aque ------------------------------------------------------------ AqueK241_Aque ------------------------------------------------------------ AqueK242_Aque ---------------------------------------S-------------------- YSK_Smoe ------------------------------------------------------------ GK082_Glam -------------------------------------------L---------------- MST4_Hsap --------------P--------------------------------------------- MST3_Hsap ------------------------------------------------------------ MST4_Mmus --------------P--------------------------------------------- MST3_Mmus ------------------------------------------------------------ gck-1_Cele SG---GATTITLG----------------------------------------------- SPS1_Scer --------------TQISKEELSPI------------------------------TQDSP KIC1_Scer FEDNEI----------------------I-----T-A--------E-------NDVNTEA CG5169_Dmel SN-KHATTTMLNAAP--------------------------------------------- YSK1_Mmus --------------P--------------------------------------------- YSK1_Hsap --------------P--------------------------------------------- SvkA_Ddis --------------V---------VSTPIKEQQQQ-Q--------Q-------PTPVTTP 17911_Tthe -----------NKGS----------NQNIT-QQH-S---------DSDN----------- YSK_Spur --------------P--------------------------------------------- CC1G_11537_Ccin FGDSA-----------------------------S-T--------E-------PEPFTVP CC1G_00304_Ccin SN-SQ-----------------------------AAH--------S-------TVMIKNP CC1G_13722_Ccin -----------------------------------------------------PLPSS-- AqueK239_Aque ------------------------------------------------------------ AqueK240_Aque FN-KE-----------------------------E-T--------S-------PVPVPVP AqueK241_Aque FN-KE-----------------------------E-T--------S-------PVPVPVP AqueK242_Aque ------------------------------------------------------------ YSK_Smoe -------------------------ETSLDSQGEA-Y--------DPDEASESSSPIFDS GK082_Glam -----------TSPP----------PPHLE-QNV-GQLSATGEDINGQD----------- MST4_Hsap -----------------------------------------------------D------ MST3_Hsap -----------------------------------------------------D------ MST4_Mmus -----------------------------------------------------D------ MST3_Mmus -----------------------------------------------------D------ gck-1_Cele ------------------------------------------------------------ SPS1_Scer -----------------------------------------------------TSSLNME KIC1_Scer --------PKISKSISS-------------LNAGNSSRDDFIPS----ISNE-V------ CG5169_Dmel -----------------------------------------------------P------ YSK1_Mmus ------------------------------------------------------------ YSK1_Hsap ------------------------------------------------------------ SvkA_Ddis --------QQPVTTTTTTP----------------------------------------- 17911_Tthe ---I-------------------------------------------------------- YSK_Spur -----------------------------------------------------Q------ CC1G_11537_Ccin --------PPFTRPLTPPQSTTPVTNEWNTIHH-VPSADDFASSTSNTLRRADN------ CC1G_00304_Ccin -----------------------------------------------------P------ CC1G_13722_Ccin ---------------AKSSRF--------------------------------E------ AqueK239_Aque ------------------------------------------------------------ AqueK240_Aque --------T--------------------------------------------P------ AqueK241_Aque --------T--------------------------------------------P------ AqueK242_Aque ------------------------------------------------------------ YSK_Smoe GTFVAREKSSESTSNSETPRY--------------------------------Q------ GK082_Glam --VI---------------------------LPLQSVADGFTDSLQG------------- MST4_Hsap -PK--------------KVQ-NGA-E----Q----------------------------- MST3_Hsap -PK--------------NLE-NGA-L----Q----------------------------- MST4_Mmus -PK--------------KLQ-NGE-E----Q----------------------------- MST3_Mmus -PK--------------NLE-NGT-L----Q----------------------------- gck-1_Cele ------------------SP-NGS-P----T----------------------------- SPS1_Scer SPY--------------LLH-GQT-VTPITN----------------------------- KIC1_Scer -NG--------------NIN-NNK-M---RPHLPPLSSGNNYYSQSTPALPLLQTKFNKT CG5169_Dmel -PS--------------SVTSSSS-A----S----------------------------- YSK1_Mmus -HS--------------KLH-KGT-A----L----------------------------- YSK1_Hsap -HS--------------KLH-KGT-A----L----------------------------- SvkA_Ddis --TTET--------KVRSL----------------------------------------- 17911_Tthe -------------------M-NYL-Q----T----------------------------- YSK_Spur -------------------------Y----I----------------------------- CC1G_11537_Ccin -PP--------------IAE-PGE-E----PQ-PIIS----------PDVP--------- CC1G_00304_Ccin -PH--------------LAE-SDD-I----A----------------------------- CC1G_13722_Ccin -PDT-----------VRTVQ-HAP------A----------------------------- AqueK239_Aque ------------------------------------------------------------ AqueK240_Aque -PA--------------PVS-NGP-I---------------------------------- AqueK241_Aque -PA--------------PVS-NGP-I---------------------------------- AqueK242_Aque ------------------SE-NAY-P----P----------------------------- YSK_Smoe -PQLERSESSLQEDSAKNLA-EAKAA----L----------------------------- GK082_Glam -------------------G-GCA-R----V----------------------------- MST4_Hsap ------------------------------------------------------------ MST3_Hsap ----------------------PS------------------------------------ MST4_Mmus ------------------------------------------------------------ MST3_Mmus ----------------------LS------------------------------------ gck-1_Cele ----------------------SS----------------------------LA---RT- SPS1_Scer ----------------------PSS--------------------------------SSF KIC1_Scer SKGPPTSGLT--TAPTSIEIEIPEELPNSALP----TPASADPV-LIPSTKARS---ST- CG5169_Dmel ----------------------EL-----------------------------Q---QK- YSK1_Mmus ----------------------HS------------------------------------ YSK1_Hsap ----------------------HS------------------------------------ SvkA_Ddis -----------------------------------------------------S---NS- 17911_Tthe ----------------------DS----------------------------D---SSQ- YSK_Spur ----------------------PE------------------------------------ CC1G_11537_Ccin ------SPLEASLAPQ------PIQIPEP--PREELQPAFIQPHLGLPAEDLPS---FT- CC1G_00304_Ccin ----------------------DD------DIPNGAPPAYSGSV-RSA-----RRASYA- CC1G_13722_Ccin ----------------------PS-----------------SAK-RA------------- AqueK239_Aque ------------------------------------------------------------ AqueK240_Aque ---------------------------------------------NGLSTNLTS---ND- AqueK241_Aque ---------------------------------------------NGLSTNLTS---Nx- AqueK242_Aque ----------------------ST------------------------------------ YSK_Smoe ----------------------QS-----------------GSR-KGMGREKQS---SS- GK082_Glam ----------------------ST----------------------------D---ESN- MST4_Hsap ------------------------------------------------------------ MST3_Hsap ------------------------------------------------------------ MST4_Mmus ------------------------------------------------------------ MST3_Mmus ------------------------------------------------------------ gck-1_Cele Q--S----------MVSP------------------------------------------ SPS1_Scer R--K----------CTQPV------------------F---------------------- KIC1_Scer V--TAGTPSSSSSIQYKSP------------------SNVPRRLTVSNNRPEHCPSTITN CG5169_Dmel R--S----------SSKP------------------------------------------ YSK1_Mmus ------------------------------------------------------------ YSK1_Hsap ------------------------------------------------------------ SvkA_Ddis ---S----------QTTPV------------------K---------------------- 17911_Tthe E-Q--------------------------------------------------------- YSK_Spur ------------------------------------------------------------ CC1G_11537_Ccin L--SQQTPGRSTPSRLDPP------------------AR---------SKPATHQSTISL CC1G_00304_Ccin ERSS----------TDGPGTVLNEADLGTGVDTIRPVK---------------------- CC1G_13722_Ccin ---V----------QRE------------------------------------------- AqueK239_Aque ------------------------------------------------------------ AqueK240_Aque D-ER----------VSDPD------------------S---------------------- AqueK241_Aque x-xx----------xxxxx------------------x---------------------- AqueK242_Aque ------------------------------------------------------------ YSK_Smoe K--R----------REDPV------------------V---------------------- GK082_Glam E-P--------------------------------------------------------- MST4_Hsap ------------------------------------------------------------ MST3_Hsap ------------------------------------------------------------ MST4_Mmus ------------------------------------------------------------ MST3_Mmus ------------------------------------------------------------ gck-1_Cele ------------------------------------------------------------ SPS1_Scer ------------------------------------------------------------ KIC1_Scer QKLGSAVASNSGISSTPNNSNNYNNNTDSENSRGSSGSNTANSTQMGITNPGNVTKLSTH CG5169_Dmel ------------------------------------------------------------ YSK1_Mmus ------------------------------------------------------------ YSK1_Hsap ------------------------------------------------------------ SvkA_Ddis ------------------------------------------------------------ 17911_Tthe ------------------------------------------------------------ YSK_Spur ------------------------------------------------------------ CC1G_11537_Ccin DNTSAPGNGNLGVTY--SPSPIV------------------------------------- CC1G_00304_Ccin ------------------------------------------------------------ CC1G_13722_Ccin ------------------------------------------------------------ AqueK239_Aque ------------------------------------------------------------ AqueK240_Aque ------------------------------------------------------------ AqueK241_Aque ------------------------------------------------------------ AqueK242_Aque ------------------------------------------------------------ YSK_Smoe ------------------------------------------------------------ GK082_Glam ------------------------------------------------------------ MST4_Hsap ------------------------------------------------------------ MST3_Hsap ------------------------------------------------------------ MST4_Mmus ------------------------------------------------------------ MST3_Mmus ------------------------------------------------------------ gck-1_Cele ----------------------------------------------SGQRSGSAQSW--- SPS1_Scer --------------------------EL-------------------------------- KIC1_Scer KASSPSRPLFGVGTSPNRKPAGSPTQNIGHNSTHTN------------------------ CG5169_Dmel ----------------------------------------------ELRQSRSAAPLDQV YSK1_Mmus ------------------------------------------------------------ YSK1_Hsap ------------------------------------------------------------ SvkA_Ddis --------------------------TTVAATTAPATTP--ASNAPT------------- 17911_Tthe ---------------------------------------SCNTDHPS------------- YSK_Spur ------------------------------------------------------------ CC1G_11537_Ccin --------------------------RTRSATTLPA------------------------ CC1G_00304_Ccin --------------------------KVDAAGSL-------------------------- CC1G_13722_Ccin -----------------------------PSDDYED-YDDQYEDYPA------------- AqueK239_Aque ------------------------------------------------------------ AqueK240_Aque --------------------------RL-------------------------------- AqueK241_Aque --------------------------xx-------------------------------- AqueK242_Aque ------------------------------------------------------------ YSK_Smoe --------------------------TTDPSTSADPGRKSSYLDVPK------------- GK082_Glam ----------------------------------------SPTIHPS------------- MST4_Hsap ------------------------------------------------------------ MST3_Hsap ------------------------------------------------------------ MST4_Mmus ------------------------------------------------------------ MST3_Mmus ------------------------------------------------------------ gck-1_Cele ------------------------------------------------------------ SPS1_Scer ------------------------------------------------------------ KIC1_Scer ------------------------------------------------------------ CG5169_Dmel EDRRASLGLPLQSSVPTPSTAEQQQQRRSSQRESFHANNAALVASCSSSSNNHSHEEHVA YSK1_Mmus ------------------------------------------------------------ YSK1_Hsap ------------------------------------------------------------ SvkA_Ddis ------------------------------------------------------------ 17911_Tthe -----------------NH----------------------------------------- YSK_Spur ------------------------------------------------------------ CC1G_11537_Ccin ------------------------------------------------------------ CC1G_00304_Ccin ------------------------------------------------------------ CC1G_13722_Ccin ------------------------------------------------------------ AqueK239_Aque ------------------------------------------------------------ AqueK240_Aque ------------------------------------------------------------ AqueK241_Aque ------------------------------------------------------------ AqueK242_Aque ------------------------------------------------------------ YSK_Smoe ------------------------------------------------------------ GK082_Glam -----------------EL----------------------------------------- MST4_Hsap -----D------------------------------------------------------ MST3_Hsap -----D-------------------L--D-------RN----K----------------- MST4_Mmus -----D------------------------------------------------------ MST3_Mmus -----D-------------------L--E-------RN----K----------------- gck-1_Cele -----E-------------------L--E-------R----------------------- SPS1_Scer -----D-------------------SGMD-------ID----SGCPNAQAETEIVPLSNH KIC1_Scer -----LAPP----------------P--TMKPMANSKDNKDIL----------------- CG5169_Dmel TNHASH-------------------V--K-------HS----G----------------- YSK1_Mmus ----------------------------S-------QK----P----------------- YSK1_Hsap ----------------------------S-------QK----P----------------- SvkA_Ddis -----S-------------------T--T-------PN----G----------------- 17911_Tthe ----YI-------------------Q--K-------MN----K----------------- YSK_Spur -----P-------------------P--H-------PE----P----------------- CC1G_11537_Ccin -----IQPP----------------P---------------------------------- CC1G_00304_Ccin -----R--LSTGYLGSIRKEGSGSSY-ST-------HK----R----------------- CC1G_13722_Ccin -----K-------------------MAAL-------QD----K----------------- AqueK239_Aque ------------------------------------------------------------ AqueK240_Aque ----SD-------------------Q--S-------ME----G----------------- AqueK241_Aque ----xx-------------------x--x-------xx----x----------------- AqueK242_Aque ------------------------------------------------------------ YSK_Smoe -----V-------------------R--L-------SS----G----------------- GK082_Glam ----VH-------------------K--D-------LS----N----------------- MST4_Hsap --------------LVQT--LSC------------------------------------- MST3_Hsap -----MK--DI--PKRPF--SQC------------------------------------- MST4_Mmus --------------LVQT--LSC------------------------------------- MST3_Mmus -----MK--DI--PKRPF--SQC------------------------------------- gck-1_Cele -------------GNRPM--SERVSSQV---------SPSKYN-QHRTSSSNGVQGGSGG SPS1_Scer NKKHKKN--DIQALKIEK--FDY------------------------------------- KIC1_Scer -----LQ--PL--NSIPS--SSTLNTISGNSSNNLTSSNYFSN-EKEG------------ CG5169_Dmel -----AG---Q-RLVQTN--SAC------------------------------------- YSK1_Mmus -----AE--PI--KRQPR--SQC------------------------------------- YSK1_Hsap -----AE--PV--KRQPR--SQC------------------------------------- SvkA_Ddis -----AA--VT-QQQAPR--ASA------------------------------------- 17911_Tthe -----CT------NEQEK--RKILEGAL---------DKVFEQ----------------- YSK_Spur -----VE--SI-PRRQPK--SEC------------------------------------- CC1G_11537_Ccin ----------V--SIIPRAFVQQSSPVKS------------------------------- CC1G_00304_Ccin -----SA--SE-G-ARAG--RAM------------------------------------- CC1G_13722_Ccin -----VDDLHI-EDDVPD--TTM------------------------------------- AqueK239_Aque ------------------------------------------------------------ AqueK240_Aque -----VE--PV-RPVEPV--IPV------------------------------------- AqueK241_Aque -----xx--xx-xxxxxx--xxx------------------------------------- AqueK242_Aque --------------SEPI--STS------------------------------------- YSK_Smoe -----EEEHAR-TLITEG--SPA------------------------------------- GK082_Glam -----AT--PL--KDTVN--RPTTAVKL---------HSVLSQDPSQKTQIHIPGAQ--- MST4_Hsap ------------------------------------------------------------ MST3_Hsap ------------------------------------------------------------ MST4_Mmus ------------------------------------------------------------ MST3_Mmus ------------------------------------------------------------ gck-1_Cele RREYINGSGSGL---------------------NGNSSNQNHSEYSDAVRQRGPGGSGGR SPS1_Scer ------------------------------------------------------------ KIC1_Scer ------------------------------------------------------------ CG5169_Dmel ------------------------------------------------------------ YSK1_Mmus ------------------------------------------------------------ YSK1_Hsap ------------------------------------------------------------ SvkA_Ddis ------------------------------------------------------------ 17911_Tthe ------------------------------------------------------------ YSK_Spur ------------------------------------------------------------ CC1G_11537_Ccin ------------------------------------------------------------ CC1G_00304_Ccin ------------------------------------------------------------ CC1G_13722_Ccin ------------------------------------------------------------ AqueK239_Aque ------------------------------------------------------------ AqueK240_Aque ------------------------------------------------------------ AqueK241_Aque ------------------------------------------------------------ AqueK242_Aque ------------------------------------------------------------ YSK_Smoe ------------------------------------------------------------ GK082_Glam -----------ITDALKVPQVPQIPAIPPAPAFS-DSVSLSARHRTDKYSLTSPGPS-SR MST4_Hsap --------------------------------------------LS-------------- MST3_Hsap --------------------------------------------LS-------------- MST4_Mmus --------------------------------------------LS-------------- MST3_Mmus --------------------------------------------LS-------------- gck-1_Cele LDYRESHVPTSSQENLNHGRMYGYGAPPPSREANNVPMPRVKGALD-------------- SPS1_Scer --------------------------------------------LK-------------- KIC1_Scer ---------------------------------------------SRVNGDFKRNNPNLK CG5169_Dmel --------------------------------------------LN-------------- YSK1_Mmus --------------------------------------------LS-------------- YSK1_Hsap --------------------------------------------LS-------------- SvkA_Ddis --------------------------------------------LT-------------- 17911_Tthe ------------------------------------------------------------ YSK_Spur --------------------------------------------IQ-------------- CC1G_11537_Ccin ------------------------------------------------------------ CC1G_00304_Ccin --------------------------------------------VD-------------- CC1G_13722_Ccin --------------------------------------------LD-------------- AqueK239_Aque ------------------------------------------------------------ AqueK240_Aque --------------------------------------------ID-------------- AqueK241_Aque --------------------------------------------xx-------------- AqueK242_Aque --------------------------------------------LS-------------- YSK_Smoe --------------------------------------------LS-------------- GK082_Glam SELRKLSFNSSD--------PPGYKTPPPPSFITSSKLEASK-TYS-------------- MST4_Hsap ---MIITPAFA-----------------------------------------------EL MST3_Hsap ---TIISPLFA-----------------------------------------------EL MST4_Mmus ---MIITPAFA-----------------------------------------------EL MST3_Mmus ---TIISPLFA-----------------------------------------------EL gck-1_Cele ---CSLLPAIE-----------------------------------------------HL SPS1_Scer ---NIVSHILN-----------------------------------------------RM KIC1_Scer LQMPLPTPVVRNKLLDPNTATSQNNNGMPGSAGISTNENINQFGFNTSSASNIPVSMTPI CG5169_Dmel ---NFLFPVLS-----------------------------------------------DI YSK1_Mmus ---TLVRPVFG-----------------------------------------------EL YSK1_Hsap ---TLVRPVFG-----------------------------------------------EL SvkA_Ddis ---SVIYPVLS-----------------------------------------------KL 17911_Tthe --------YIS-----------------------------------------------YS YSK_Spur ---SLLGPILR-----------------------------------------------DL CC1G_11537_Ccin -------AT--------------------------------------------------F CC1G_00304_Ccin ---EVVLPVLQ-----------------------------------------------RA CC1G_13722_Ccin ---SVVLPAIA-----------------------------------------------SL AqueK239_Aque ------------------------------------------------------------ AqueK240_Aque ---RIIHPVMN-----------------------------------------------RL AqueK241_Aque ---xxxxxxxx-----------------------------------------------xL AqueK242_Aque ---KIIMPLLA-----------------------------------------------QF YSK_Smoe ---LLLIPALK-----------------------------------------------ET GK082_Glam ----TISATLS-----------------------------------------------RS MST4_Hsap K-----------QQDENNAS---------------------------------------- MST3_Hsap K-----------EKSQACGG---------------------------------------- MST4_Mmus K-----------QQDENNAS---------------------------------------- MST3_Mmus K-----------EKSQACGG---------------------------------------- gck-1_Cele S----------------------------------------------------------- SPS1_Scer Y-----------DRARDD------------------------------------------ KIC1_Scer S-----------EKHIDFGGKIKRSQSISNRKNSSASEHPLNILGSSVSGNVSGIGNNNV CG5169_Dmel Q-----------RKYSGGGSAGS----------------------------------GGS YSK1_Mmus K-----------EKHKQSGG---------------------------------------- YSK1_Hsap K-----------EKHKQSGG---------------------------------------- SvkA_Ddis L-----------KNTSDE-N---------------------------------------- 17911_Tthe ------------KNSQNHEY---------------------------------------- YSK_Spur K-----------RKNE---G---------------------------------------- CC1G_11537_Ccin T-----------DDPSARGGP--------------------------------------- CC1G_00304_Ccin I-----------RDDMDA------------------------------------------ CC1G_13722_Ccin F-----------PRVSTQ-E---------------------------------------- AqueK239_Aque ------------------------------------------------------------ AqueK240_Aque K-----------SEAFEGGGSG------------------------------------NS AqueK241_Aque K-----------SEGFEGGGSG------------------------------------NS AqueK242_Aque D-----------APVDGNWRT--------------------------------------- YSK_Smoe A-----------AEQSEG-S---------------------------------------- GK082_Glam QKNSVDILIATLRTVAASH----------------------------------------- MST4_Hsap ------------------------------------------------------------ MST3_Hsap ------------------------------------------------------------ MST4_Mmus ------------------------------------------------------------ MST3_Mmus ------------------------------------------------------------ gck-1_Cele ------------------------------------------------------------ SPS1_Scer ------------------------------------------------------------ KIC1_Scer GSNNNSGPNNSVPLSANTGNTTIKANSTTIATSSSAAASTTAPISQQTIPSGTQFNHILS CG5169_Dmel G----------------------------------------------------------- YSK1_Mmus ------------------------------------------------------------ YSK1_Hsap ------------------------------------------------------------ SvkA_Ddis ------------------------------------------------------------ 17911_Tthe ------------------------------------------------------------ YSK_Spur ------------------------------------------------------------ CC1G_11537_Ccin ------------------------------------------------------------ CC1G_00304_Ccin ------------------------------------------------------------ CC1G_13722_Ccin ------------------------------------------------------------ AqueK239_Aque ------------------------------------------------------------ AqueK240_Aque P-------ER-------------------------------------------------- AqueK241_Aque P-------ER-------------------------------------------------- AqueK242_Aque ------------------------------------------------------------ YSK_Smoe ------------------------------------------------------------ GK082_Glam ------------------------------------------------------------ MST4_Hsap --------------------------------------------RNQAIEELEKSIAVAE MST3_Hsap --------------------------------------------NLGSIEELRGAIYLAE MST4_Mmus --------------------------------------------RNQAIEELEKSIAVAE MST3_Mmus --------------------------------------------NLGSIEELRGAIYLAE gck-1_Cele ----------------------------------------RTRHATAALDQLRHVFRDVE SPS1_Scer -------------------------------------------ETRKYVNEMLKQFIKTE KIC1_Scer SAATAANSVNSLGFGMCPPPQSLQMEMFLDLESFLPGKQRRVDRKPQVLKELENLLQMFE CG5169_Dmel ---------------------------------------GRNIGVGSDIGDLKSVFELAE YSK1_Mmus --------------------------------------------SVGALEELENAFSLAE YSK1_Hsap --------------------------------------------SVGALEELENAFSLAE SvkA_Ddis --------------------------------------------VINALAQLKMAFDNAE 17911_Tthe --------------------------------------------LTLALQQLHCAFDEME YSK_Spur --------------------------------------------LSGAIDELQNSFDMAE CC1G_11537_Ccin -----------------------------------------------GLKDVLKIPSLTT CC1G_00304_Ccin -------------------------------------------REIESLSMLQRGFEELK CC1G_13722_Ccin --------------------------------------------ARVALSALQRAFTEAE AqueK239_Aque ------------------------------------------------------------ AqueK240_Aque ------------------------------------EVPSPDRRSNLAIEELERAFELLE AqueK241_Aque ------------------------------------EVSSPDRWSNLAIEELERAFELLE AqueK242_Aque ----------------------------------------SGQEAMVSIAELMAAFREVE YSK_Smoe --------------------------------------------ALRAAADAADALIDLE GK082_Glam --------------------------------------------QVESVEQLVSEFS--- MST4_Hsap AACPGITDK--------------------------------------------------- MST3_Hsap EACPGISDT--------------------------------------------------- MST4_Mmus TACPGITDK--------------------------------------------------- MST3_Mmus EACPGISDT--------------------------------------------------- gck-1_Cele DSCPGICNE--------------------------------------------------- SPS1_Scer ANVPGFNEV--------------------------------------------------- KIC1_Scer EGLPCIEHA--------------------------------------------------- CG5169_Dmel RSSPGVSDL--------------------------------------------------- YSK1_Mmus ESCPGISDK--------------------------------------------------- YSK1_Hsap ESCPGISDK--------------------------------------------------- SvkA_Ddis KAKPGITHS--------------------------------------------------- 17911_Tthe REENGSSKK--------------------------------------------------- YSK_Spur ESSPGICDR--------------------------------------------------- CC1G_11537_Ccin ESHLGMVDLLPPSPSALVTSNRSPGAHGISKPSRSYGGPMDYPSPATSKFAMEQDRSQRS CC1G_00304_Ccin EANSELAYN--------------------------------------------------- CC1G_13722_Ccin RIIPGVTHE--------------------------------------------------- AqueK239_Aque ------------------------------------------------------------ AqueK240_Aque SSNPGFSEI--------------------------------------------------- AqueK241_Aque SSNPGFSEI--------------------------------------------------- AqueK242_Aque ETRPGFCDE--------------------------------------------------- YSK_Smoe RMAPGACEV--------------------------------------------------- GK082_Glam ALGNDFCDS--------------------------------------------------- MST4_Hsap --------------------------------------------------------MV-- MST3_Hsap --------------------------------------------------------MV-- MST4_Mmus --------------------------------------------------------MV-- MST3_Mmus --------------------------------------------------------MV-- gck-1_Cele --------------------------------------------------------LI-- SPS1_Scer --------------------------------------------------------FI-- KIC1_Scer --------------------------------------------------------LK-- CG5169_Dmel --------------------------------------------------------FM-- YSK1_Mmus --------------------------------------------------------LM-- YSK1_Hsap --------------------------------------------------------LM-- SvkA_Ddis --------------------------------------------------------LI-- 17911_Tthe --------------------------------------------------------IL-- YSK_Spur --------------------------------------------------------LV-- CC1G_11537_Ccin AQNSISVDGLPTLEPLNYAALISNGDPQNELMQTIEGLASWLKVVDQGFQAMLEHSAFGD CC1G_00304_Ccin --------------------------------------------------------VI-- CC1G_13722_Ccin --------------------------------------------------------LV-- AqueK239_Aque ------------------------------------------------------------ AqueK240_Aque --------------------------------------------------------FI-- AqueK241_Aque --------------------------------------------------------FI-- AqueK242_Aque --------------------------------------------------------LV-- YSK_Smoe --------------------------------------------------------LV-- GK082_Glam --------------------------------------------------------FI-- MST4_Hsap ------KKLIEKFQK-CSA----------------------------------------- MST3_Hsap ------AQLVQRLQR-YSLSG--------------------------------------- MST4_Mmus ------KKLIEKFQK-CSA----------------------------------------- MST3_Mmus ------AQLVQRLQR-YSLSG--------------------------------------- gck-1_Cele ------EELMQRIAV-PQVSQ--------------------------------------- SPS1_Scer ------EEISLRIEA-I------------------------------------------- KIC1_Scer ------EQLIST------------------------------------------------ CG5169_Dmel ------KELIHMLVPGYSETR--------------------------------------- YSK1_Mmus ------VHLVERVQR-FSHSR--------------------------------------- YSK1_Hsap ------VHLVERVQR-FSHNR--------------------------------------- SvkA_Ddis ------AQIIETL----------------------------------------------- 17911_Tthe ------SEVYKNLCT-GSNTP--NNRGQ--------------NNNNHIATSVNSNNNLSH YSK_Spur ------SQVVSRVES-PPRPS--------------------------------------- CC1G_11537_Ccin ILEEGNEQYGSS------------------------------------------------ CC1G_00304_Ccin ------LDILQGIND-NNAIKRHV------------------------QTSR---GLFPH CC1G_13722_Ccin ------NEIVDSVER-V------------------------------------------- AqueK239_Aque ------------TT---------------------------------------------- AqueK240_Aque ------KCLVTQLQ---------------------------------------------- AqueK241_Aque ------KCLVTQLQ---------------------------------------------- AqueK242_Aque ------QRFVLFVRS-RC-PT--------------------------------------- YSK_Smoe ------TRLLKRLGS-AEDPS--VKTLQDLARKALVVDHPPGAGDGHLQSTT---QQFDF GK082_Glam ------KRLCLTKLS-HDRET--------------------------------------- MST4_Hsap ------------------------------------------------------------ MST3_Hsap ------------------------------------------------------------ MST4_Mmus ------------------------------------------------------------ MST3_Mmus ------------------------------------------------------------ gck-1_Cele --SD---------------------LD--------------------------------- SPS1_Scer ------------------------------------------------------------ KIC1_Scer ------------------------------------------------------------ CG5169_Dmel -------------------------IN--------------------------------- YSK1_Mmus ------------------------------------------------------------ YSK1_Hsap ------------------------------------------------------------ SvkA_Ddis ------------------------------------------------------------ 17911_Tthe SHIHNHN----------------------------THSSNQD---------------SYG YSK_Spur ------------------------------------------------------------ CC1G_11537_Ccin ------------------------------------------------------------ CC1G_00304_Ccin KRITRKSEMTSKGLVVTEETEEVSGLP-------ESSNGVPPAQAEAETPRRSPIAELLY CC1G_13722_Ccin ------------------------------------------------------------ AqueK239_Aque ------------------------------------------------------------ AqueK240_Aque ------------------------------------------------------------ AqueK241_Aque ------------------------------------------------------------ AqueK242_Aque --TN---------------------IP-------ASSSTSPSPSSE-----------PA- YSK_Smoe AKSG---------------------QQRGQPNLESSESSGLSPLAS-----------FLL GK082_Glam ----LLL----------------------------SATSLQD------------------ MST4_Hsap --------------DESP MST3_Hsap ------------GGTSSH MST4_Mmus --------------DESP MST3_Mmus ------------GGASAH gck-1_Cele -------AAIRRLTTPPS SPS1_Scer -------------KKGFV KIC1_Scer -----------PIKDNEH CG5169_Dmel -------TIMDRAIRNRK YSK1_Mmus -----------NHLTSTR YSK1_Hsap -----------NHLTSTR SvkA_Ddis ----------------KR 17911_Tthe N---QHLVQ--YPYKNSN YSK_Spur -----------VSRSGQH CC1G_11537_Ccin -----------TNESDGQ CC1G_00304_Ccin MRWLEGLRLKWPSIMTGS CC1G_13722_Ccin --------------DDDR AqueK239_Aque --------------DPPD AqueK240_Aque --------------RRSM AqueK241_Aque --------------RRSM AqueK242_Aque -------GGRSQRRSPNV YSK_Smoe SRWQ---SQLPRDMNCYN GK082_Glam -----PLLKALNDRSSVQ