CLUSTAL W (1.83) multiple sequence alignment Spk376_Spur M----------------------------------------------------------- Spk383_Spur MEDKPNIPGLTQETEQQSIQRRA----NRPRRQPAGVPDDQPTVEMRAALAEGASDAIAT Spk379_Spur MGIFI----LHSS----------------------------------------------- Spk380_Spur MDPQDEIA-----LPENA-LQHIRST-----WKEMG------------------------ Spk370_Spur MKKIVNLE-----VEAKSVLERIEIF-----AIDVGVAEDLP------------------ Spk369_Spur MDENPDLG-----LSSPKPQRRAQQMTNRRRRPQASGAHDGH------------------ Spk400_Spur MKNIVNLE-----VEAKSILERIKIF-----AIDVGVVEDLT------------------ Spk401_Spur M----------------------------------------------------------- * Spk376_Spur ------------------------------------------------------------ Spk383_Spur ATNQLVPVTVLDNGDDGIIIEAGESTRQSLEQQLAVADAQLK-DFKALQEAAKSLTGSTE Spk379_Spur ------------------------------------------------------------ Spk380_Spur -----------------SRCEKVESSWKEKVIQLTSDLTAARTYIQTVEAELLHV---Q- Spk370_Spur -----------------------EIRTVKLVPKIHTKSAELRREIEYLREERVLY---TE Spk369_Spur -------------------------------------TAEVLAAVEQ----TNRA---TD Spk400_Spur -----------------------EIRTVKLVSQINTKTAELRREIEYLREERVLF---RE Spk401_Spur ------------------------------------------------------------ Spk376_Spur ------------------------------------------------------------ Spk383_Spur DTPAGALAKGLVSAREEKQAD-------------VR--------MVETEIRQIQREKDQT Spk379_Spur ------------------------------------------------------------ Spk380_Spur -ES-------------QTNCW-------------PN--------IIKR-----RWFPRR- Spk370_Spur DSS-------------KIQAQ-------------TN--------LIVEKESQLRRYTER- Spk369_Spur DGG-------------ALVASGQAAGQLSPGSLAPGLLAPETDDRSVNQERVIRMTTAR- Spk400_Spur DSS-------------KIQAQ-------------TN--------LIVEKESQLRRHVER- Spk401_Spur ------------------------------------------------------------ Spk376_Spur ------------------------------------------------------------ Spk383_Spur QTTLKLFVIAASVYSSLQKDKAIL--------------------ERQIIKL--------- Spk379_Spur -------FLAASVYSSLQEDKAIL--------------------EKQIFKL--------- Spk380_Spur ---------KKSKVVPNQGER-----SGKSEQ--TKELDEKSNLTNQL---KNLSNAG-G Spk370_Spur ---------MNSRINSLEKDKAIL--------------------ESQIGKL--------- Spk369_Spur ---------PDVCLEAFQKNMEAGESSGQADEDLLKQLES---AQAQLKGYEGLAHAAAA Spk400_Spur ---------MNSRINSLEKDKAIL--------------------ESQIGKL--------- Spk401_Spur ------------------------------------------------------------ Spk376_Spur ------------------------------------------------------------ Spk383_Spur ---KDGSEAANRMVKEMSQKNKEMANGRKEAEREKKQAEGEKAKAEREKVKAEKEKVKAE Spk379_Spur ---KDGSEAANMMVKEMAQKNKEMANERKEAEREKNQAE-------KEKVKAEKEKVKAE Spk380_Spur TSPKEVDR----------------TED--------------------------------- Spk370_Spur ---MECDEAAKRLTQKLMEQNRTLEEDNQ------------------------------- Spk369_Spur ITGSTVDTPAETLAKSLMDAWGEQRFNQD------------------------------- Spk400_Spur ---MECDKAAKRLTEKLVEQNKTLEEENQ------------------------------- Spk401_Spur ------------------------------------------------------------ Spk376_Spur ------------------------------------------------------------ Spk383_Spur KLMKEMEKKMKLEERKRGYVERLNQVLLEKLCHMQQDIAQKTDDIAQKTDDIALNTQIIA Spk379_Spur KLMEEMEKKMKLEESKREYVERLNQVLLEKLCHMEQDIAQKTDDI-------AHNTQMIA Spk380_Spur -----------------------FQCTLTKVRGLEYDCQRLQEKN--------------- Spk370_Spur -------------------------DMEEKVGLLEYETDRQTDT---------------- Spk369_Spur -------------------------QMESRIEHIKTEKEQVQDEL--------------- Spk400_Spur -------------------------DMEKKVGLLEYETDGQTDKI--------------- Spk401_Spur ------------------------------------------------------------ Spk376_Spur ------------------------------REAKTNVDRVVIACLHFVSPQELAIQDLMS Spk383_Spur LKNEQI---IQLKGI--NDKLQEITDLRLMREAKTNVDRVVIACLNFVSPQELAIQDLMS Spk379_Spur LKNEQISHLNKLKEM--NDNLQEITDFRLMQEAKTNVDRVVIACLNFVSPQELAIQDLMS Spk380_Spur ---------QGLRDLIENLGAHLGKTQGPILDVRTIADVAVIATLGSNPCTELSMHDVIT Spk370_Spur ------------------MRYNEMYPNSAINDVQSQSDHAVIASLTTLRCKKLDLSTLRE Spk369_Spur -----------------KMRYNEMYPNSAINDVQSQSDHAVIASLTTLRCKKLDLSTLRE Spk400_Spur ---------KRLYDLMERMRYNEMYPNSAINDVQSQSDHAVIASLTTLRCKKLDLSTLRE Spk401_Spur -------------------RYNEMYPNSAINDVHSQSDHAVIASLTTLRCKKLDHSTLRE :.:: * .*** * :* : Spk376_Spur FNHSSA-SDQTILETVGKGSYGEVMLGRLNGEKDPVVIKRALVKQNLTAELEESDRKQCN Spk383_Spur FNHSSA-SGQTILEFVGKGGYGEVMLGRLNGEKDPVAIKRALVKQNLTAELEESDRKRRN Spk379_Spur FNHSSA-SDQNILETVGKGSYGEVMLGRLNGEKDPVVIKRALVKQNLTAELEESDGKQRN Spk380_Spur FHATSILDNDFKFKEIGRGAFGRVLLARLTASSDTVAIKEPLIPPYFSPPKIEAERRANF Spk370_Spur -SKSGD-SSKLELDMIGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHQKGEAAENEWKANQ Spk369_Spur -SKSDD-SSKLELDMIGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHLKGEAAENEWKANQ Spk400_Spur -SKSDD-SSKLELDMIGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHLKGEAAENEWKANQ Spk401_Spur -SKSDD-SSKLELDMIGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHLKGEAAENEWKANQ :. ... :. :*.*.:* *:*.:* . ...*.**.. : . * : : Spk376_Spur IRCEKEARAGLMMS-TSPYFPRFLGTVMTDGDHCLVTEFIGDKIQGKTYMLMDAICPRKG Spk383_Spur VRYEKEARAGLVMS-TSPYFPRFLGTVMINGDHCLVTEFIGDKIQGKSYVLYDAIIPRKG Spk379_Spur IRCEKEARVGLMMS-TSPYFPRFLGTVMVNGGLCLVTEFIGDKIQGKSYELYDAICPSEG Spk380_Spur GQFTKEAVVSQFLS-RSNHFPKLYGTLVLDENMCIVQEFIGDKKTGKVFPLLNIM---E- Spk370_Spur GRTRKESLVLELLK-GCPYFAQMVGTITIGRELCVVTEFVGSGQTGRPYRLHDAL---QV Spk369_Spur GRTRKESLVLELLK-GCPYFAQMVGTITIGRELCVVTEFVGSGQTGRPYRLHDAL---QE Spk400_Spur GRTRKESLCLQLLKGXCPYFAQMVGTITIGRELCXCNRVRGSGQTGRPYRLHDAL---QE Spk401_Spur GRTRKESLVLELLK-GCPYFAQMVSAITMGRELCVVTEFVGSGQTGRPYRLHDAL---QV : **: .:. . :*.:: .:: . * .. *. *: : * : : : Spk376_Spur CDPVPDVQKWNLVAIGEDIIRGVIALHGLSLLHNDIKDDNVLLEFRKNRWVAVIIDLGMV Spk383_Spur CDPEPDVQKWNLVAIGEDIIRGVMALHGRSLLHNDIKDDNVLLEYRKNRWVAVIIDLGMV Spk379_Spur CDPVPDVQKWNLVAIGEDIIRGVMALHGRSLLHNDIKDDNVLLEFRKNRWVAVIIDLGMV Spk380_Spur SNPSPFLSPPSLLDIADDVLEGIHFMHSNGLLHNDIKADNVLLELRNERWYGCIIDLGLV Spk370_Spur IDPILYPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGERWHGVIIDMGLV Spk369_Spur IDPILYPSIWNMVAIAEDLVRGVSTIHDFGLLHNDIKGDNILLEHRGERWHGVIIDMGLV Spk400_Spur IDPILYPSIWNMVAIAEDLVRGVSTIHDFGLLHNDIKGDNILLEHRGERWHGVIIDMGLV Spk401_Spur IDPILYPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGERWHGVIIDMGLV :* . .:: *.:*::.*: :*. .******* **:*** * :** . ***:*:* Spk376_Spur STVTYPHLSGSN-GSMSTHAKGY-FIHTAPEVLK--GCATSVASDVYSVGIILDCIGDFI Spk383_Spur STATYPYFSGSN-GSMSTHAKGY-FIHTAPEVLK--GCATSVASDVYSVGIILDCIGGFI Spk379_Spur STVTYPYISGSN-GSMSTHAKGY-LIRTAPEVLK--GCETSVASDVYSVGIILDCIGRVI Spk380_Spur STIAFPPHVTIKRSVMEDHKKLSGNVYVAPEVVD-DGTTLSKASDIYSVGVLLVFIGRAA Spk370_Spur TTMAYTEQRSFS-DLIPESQRLK-FPHIAPELLDSAGSQVSASTDIFAVGVQLNMIGQFI Spk369_Spur TTMAYTEQRSFS-DLIPESQRLK-FPHIAPELLDIAGSQVSASTDIFAVGVQLNMIGQFI Spk400_Spur TTMAYTEQRSFS-DLIPESQRLK-FPHIAPELLDVVGSQVSASTDIFAVGVQLNMIGQFI Spk401_Spur TTMAYTEQRSFS-DLIPESQRLK-FPHIAPELLDIAGSQVSASTDIFAVGVQLNMIGQFI :* ::. . . : : ***::. * * ::*:::**: * ** Spk376_Spur KDDDLCTLVEVCCKEDPKERPGDMEEMLPGVVDIKEKHRTVARLAGESLEEKEEE----- Spk383_Spur KDDSLRTLGDMCCKEDPKDRPGDMEEMLPGVVHIKEKHRTVARLAGELLEADTEEEQESE Spk379_Spur KDDDLRTLGDMCCKEDPKERPDDMEEMLPEVLEIKEKHRAVARLAGELLEAYIDEE---- Spk380_Spur RLQGLIAIGESCSQKAPMLRPRSLKDVIPKVRALQEQLAHES------------------ Spk370_Spur DDDELVTVGEHCCENEPHLRPKALDDIVPKLVEIKTRLKNERRLHR-------------- Spk369_Spur DDDELVTVGEHCCENEPHLRPKALDDIVPKLVEIKTRLKNERRLHR-------------- Spk400_Spur DDDELVTVGEHCCENEPHLRPKALDDIVPKLVEIKTRLKNERRLHR-------------- Spk401_Spur DDDELVMVGEHCCENEPHLRPKALDDIVPKLVEIKTRLKNERRLHR-------------- : * : : *.:: * ** :.:::* : :: : Spk376_Spur --------EDFLTDLFETGAEEEAEGEMKEGDAEVEVAEDERGEEGLEEEAREEGQVEEE Spk383_Spur EEEEERGDEDFLTDLSE---AEEAEGEQNEGDAEV---EDERGKEGLEEDAGEGGQGEEE Spk379_Spur -------------------------------------------------------QEEEE Spk380_Spur ------------------------------------------------------------ Spk370_Spur ------------------------------------------------------------ Spk369_Spur ------------------------------------------------------------ Spk400_Spur ------------------------------------------------------------ Spk401_Spur ------------------------------------------------------------ Spk376_Spur DGDAWLLHIEGEEPNGEEVQRGAEGEADEEVEEGVAEEDAGEARRHQEVGDEAGEGHREE Spk383_Spur DGDAWLLHIEGEEPNGEEVQRGAEEEADEEAEEGVAEEDGGEARRHQEVGDEA-EGDREE Spk379_Spur DGDAWLLHIEGEEPNEEEVQRGAEEEADEELEEDLAGEDRGEARRHQEVGDEAEEGDREE Spk380_Spur ------------------------------------------------------------ Spk370_Spur ------------------------------------------------------------ Spk369_Spur ------------------------------------------------------------ Spk400_Spur ------------------------------------------------------------ Spk401_Spur ------------------------------------------------------------ Spk376_Spur GNGAGDGEAEQGDAVEGVAGEEAPQGHA---------MRNEEGMDLAVEALHPNADEAQQ Spk383_Spur GNEAGDGEAEQGDAGEGVAGEEDLQVHQQGVIAVNDEMRNEEGLELAVEALHPNAEEAEQ Spk379_Spur GNEAGDEEAEQGDAGEGVAGEEAPQVHR--------HVRNEEGLELAVEGLHPNAEEAEQ Spk380_Spur ------------------------------------------------------------ Spk370_Spur ----------------------------SGTFVIES------------------------ Spk369_Spur ----------------------------SGTFVIDS------------------------ Spk400_Spur ----------------------------SGTFVIDS------------------------ Spk401_Spur ----------------------------SGTFVIDS------------------------ Spk376_Spur GGEELMLEDGEEGANDEGGEINDGEGRKKARKLLKKQQIYKFDGGQKESTLSKKQQIKKN Spk383_Spur GGEELMLEGGEEGANDEGGERNDGEV---------------------------------- Spk379_Spur GGEQLMLEDGGEGANEEGGERNDGEV---------------------------------- Spk380_Spur ------------------------------------------------------------ Spk370_Spur ---------DENG----------------------------------------------- Spk369_Spur ---------DQDG----------------------------------------------- Spk400_Spur ---------DQDG----------------------------------------------- Spk401_Spur ---------DQDG----------------------------------------------- Spk376_Spur LVEGRKKARKLSKKQQIYKFDGGQKESTLSKKQQIIKFGGRQKENQKTLKESADHQIWWK Spk383_Spur ------------------------------------------------------------ Spk379_Spur ------------------------------------------------------------ Spk380_Spur ------------------------------------------------------------ Spk370_Spur ------------------------------------------------------------ Spk369_Spur ------------------------------------------------------------ Spk400_Spur ------------------------------------------------------------ Spk401_Spur ------------------------------------------------------------ Spk376_Spur AERKPENSQRSSKSSNLVEGREKTRQLSKKQQINKFGGRQRENQTTRKEAANQTFDGRQR Spk383_Spur ------------------------------------------------------------ Spk379_Spur ------------------------------------------------------------ Spk380_Spur ------------------------------------------------------------ Spk370_Spur ------------------------------------------------------------ Spk369_Spur ------------------------------------------------------------ Spk400_Spur ------------------------------------------------------------ Spk401_Spur ------------------------------------------------------------ Spk376_Spur ENQTTLKEAANHPGWWRAERRPENSQRSSKSTRLVEGRKKATKLPKKQQIIKFDGGERAR Spk383_Spur ------------------------------------------------------------ Spk379_Spur ------------------------------------------------------------ Spk380_Spur ------------------------------------------------------------ Spk370_Spur ------------------------------------------------------------ Spk369_Spur ------------------------------------------------------------ Spk400_Spur ------------------------------------------------------------ Spk401_Spur ------------------------------------------------------------ Spk376_Spur KLPKKQQIKKNLVEGKKKARKLSKKQQIVKFGGGQK Spk383_Spur ----------------------------IEEDDGIG Spk379_Spur ----------------------------VEEDDEIG Spk380_Spur --------------------------------NSGN Spk370_Spur -----------------------------SSQGGNG Spk369_Spur -----------------------------SSQGGNG Spk400_Spur -----------------------------SSQGGNG Spk401_Spur -----------------------------SSQGGNG .