Group Family Subfamily "Yeast domains" "Worm domains" "Fly domains" "Human domains" "Human pseudogenes" Distribution AGC AKT 3 2 1 3 "1 fly, expanded in others" AGC DMPK GEK 0 1 1 4 1 1 fly/worm expanded in human AGC DMPK ROCK 0 1 1 2 1 fly/worm expanded in human AGC DMPK Unclassified 0 0 1 1 Leftover group AGC GRK BARK 0 1 1 2 1 fly/worm expanded in human AGC GRK GRK 0 1 1 5 1 1 fly/worm expanded in human AGC MAST 0 1 2 5 "1 worm, expanded in fly/human" AGC NDR 4 2 2 4 Many in all species AGC PDK 3 2 1 1 "Expanded in Yeast, Human" AGC PKA 3 2 4 5 1 Many in all species AGC PKC Alpha 0 1 2 3 "1 worm, expanded in fly/human" AGC PKC Delta 0 1 1 2 1 fly/worm expanded in human AGC PKC Eta 0 1 1 2 1 fly/worm expanded in human AGC PKC Iota 0 1 1 2 1 1 fly/worm expanded in human AGC PKC Unclassified 1 0 0 0 Leftover group AGC PKG 0 2 3 2 Several per metazoan AGC PKN 0 1 1 3 1 fly/worm expanded in human AGC RSK MSK 0 1 1 2 1 fly/worm expanded in human AGC RSK p70 1 2 1 2 2 "1 fly, expanded in worm/human" AGC RSK RSK 0 1 1 4 1 fly/worm expanded in human AGC RSK Unclassified 2 0 1 1 Leftover group AGC RSKL 0 1 1 2 1 fly/worm expanded in human AGC SGK 0 1 0 3 Worm+Human AGC Unique 0 3 0 0 Leftover group AGC YANK 0 1 1 3 1 fly/worm expanded in human Atypical A6 1 2 1 2 2 "Expanded in Human, Worm" Atypical ABC1 ABC1-A 1 1 1 2 Expanded in Human Atypical ABC1 ABC1-B 1 1 2 2 Expanded in Fly Atypical ABC1 ABC1-C 1 1 0 1 No Fly Atypical Alpha ChaK 0 3 1 2 "1 fly, expanded in worm/human" Atypical Alpha eEF2K 0 1 0 1 Worm+Human Atypical Alpha Unclassified 0 0 0 3 Leftover group Atypical BCR 0 0 0 1 Specific to Human Atypical BRD 0 1 1 4 1 fly/worm expanded in human Atypical FAST 0 0 0 1 Specific to Human Atypical G11 0 0 0 1 Specific to Human Atypical H11 0 0 0 1 Specific to Human Atypical HistK 1 0 0 0 Specific to Yeast Atypical PDHK 2 1 1 5 "Expanded in Human, Yeast" Atypical PIKK ATM 1 1 1 1 1 in all species Atypical PIKK ATR 1 1 1 1 1 in all species Atypical PIKK DNAPK 0 0 0 1 Specific to Human Atypical PIKK FRAP 2 1 1 1 Expanded in yeast Atypical PIKK SMG1 0 1 1 1 1 per metazoan Atypical PIKK TRRAP 1 1 1 1 1 in all species Atypical RIO RIO1 1 1 1 1 1 in all species Atypical RIO RIO2 1 1 1 1 1 in all species Atypical RIO RIO3 0 1 1 1 1 1 per metazoan Atypical TAF1 1 1 1 1 1 in all species Atypical TIF 0 0 1 3 Fly+Human CAMK CAMK1 4 1 1 5 "Expanded in Human, Yeast" CAMK CAMK2 0 1 1 4 1 fly/worm expanded in human CAMK CAMKL AMPK 1 2 1 2 "Expanded in Human, Worm" CAMK CAMKL BRSK 0 1 1 2 1 fly/worm expanded in human CAMK CAMKL CHK1 1 7 1 1 Expanded in Worm CAMK CAMKL GIN4 3 0 0 0 Specific to Yeast CAMK CAMKL HUNK 0 0 0 1 Specific to Human CAMK CAMKL Kin1 2 0 0 0 Specific to Yeast CAMK CAMKL Kin4 2 0 0 0 Specific to Yeast CAMK CAMKL LKB 0 1 1 1 1 per metazoan CAMK CAMKL MARK 1 2 3 4 28 Expanded in metazoans CAMK CAMKL MELK 0 1 0 1 Worm+Human CAMK CAMKL NIM1 0 1 1 1 1 per metazoan CAMK CAMKL NuaK 0 1 1 2 1 fly/worm expanded in human CAMK CAMKL PASK 2 0 1 1 No Worm CAMK CAMKL QIK 0 1 2 3 "1 worm, expanded in fly/human" CAMK CAMKL SNRK 0 1 1 1 1 per metazoan CAMK CASK 0 1 1 1 1 per metazoan CAMK DAPK 0 1 1 5 1 fly/worm expanded in human CAMK DCAMKL 0 2 1 3 Several per metazoan CAMK MAPKAPK MAPKAPK 0 2 1 3 1 "1 fly, expanded in worm/human" CAMK MAPKAPK MNK 0 1 1 2 1 1 fly/worm expanded in human CAMK MLCK 0 5 5 5 Several per metazoan CAMK PHK 0 1 1 2 3 1 fly/worm expanded in human CAMK PIM 0 2 0 3 Worm+Human CAMK PKD 0 2 1 3 "1 fly, expanded in worm/human" CAMK PSK 0 1 0 2 1 Worm+Human CAMK RAD53 1 2 1 1 2 Expanded in Fly CAMK RSKb MSKb 0 1 1 2 1 fly/worm expanded in human CAMK RSKb RSKb 0 1 1 4 1 fly/worm expanded in human CAMK Trbl 0 0 1 3 Fly+Human CAMK Trio 0 0 0 6 Specific to Human CAMK TSSK 0 4 2 5 2 Several per metazoan CAMK Unique 4 0 1 3 1 Leftover group CK1 CK1 CK1-A 0 1 2 2 3 "1 worm, expanded in fly/human" CK1 CK1 CK1-D 1 1 1 2 Expanded in Human CK1 CK1 CK1-G 3 1 1 3 1 "Expanded in Yeast, Human" CK1 CK1 Unclassified 0 0 3 0 Leftover group CK1 Dual 0 6 0 0 Specific to Worm CK1 TTBK 0 1 1 2 1 fly/worm expanded in human CK1 TTBKL 0 32 0 0 Specific to Worm CK1 Unique 0 4 0 0 Leftover group CK1 VRK 0 1 2 3 1 "1 worm, expanded in fly/human" CK1 Worm10 0 2 0 0 Specific to Worm CK1 Worm11 0 2 0 0 Specific to Worm CK1 Worm6 0 29 0 0 Specific to Worm CK1 Worm7 0 3 0 0 Specific to Worm CK1 Worm8 0 3 0 0 Specific to Worm CK1 Worm9 0 2 0 0 Specific to Worm CMGC CDK CDC2 1 2 2 3 1 Many in all species CMGC CDK CDK10 0 0 1 1 Fly+Human CMGC CDK CDK4 0 1 1 2 1 1 fly/worm expanded in human CMGC CDK CDK5 0 1 1 1 1 per metazoan CMGC CDK CDK7 1 1 1 1 1 1 in all species CMGC CDK CDK8 1 1 1 2 1 Expanded in Human CMGC CDK CDK9 0 1 1 1 1 per metazoan CMGC CDK CRK7 1 1 1 2 Expanded in Human CMGC CDK PITSLRE 0 2 1 1 Expanded in Worm CMGC CDK TAIRE 0 2 1 5 "1 fly, expanded in worm/human" CMGC CDK Unclassified 2 1 1 1 Leftover group CMGC CDKL 0 1 1 5 1 fly/worm expanded in human CMGC CLK 1 3 1 4 2 "1 fly, expanded in others" CMGC Dyrk Dyrk1 0 1 1 2 1 fly/worm expanded in human CMGC Dyrk Dyrk2 0 3 2 3 Several per metazoan CMGC Dyrk HIPK 0 1 1 4 1 fly/worm expanded in human CMGC Dyrk PRP4 0 1 1 1 1 1 per metazoan CMGC DYRK Unclassified 1 0 0 0 Leftover group CMGC GSK 4 9 3 2 Expanded in Worm CMGC MAPK Erk 5 1 1 5 4 "Expanded in Yeast, Human" CMGC MAPK Erk7 0 1 1 1 1 per metazoan CMGC MAPK Jnk 0 5 1 3 "1 fly, expanded in worm/human" CMGC MAPK nmo 0 1 1 1 1 per metazoan CMGC MAPK p38 1 3 3 4 "1 yeast, expanded in metazoans" CMGC MAPK Unclassified 0 3 0 0 Leftover group CMGC RCK 1 1 1 3 "Expanded in Human, Worm" CMGC SRPK 1 1 3 3 1 "1 worm, expanded in fly/human" CMGC Unique 1 1 0 0 Leftover group Other Aur 1 2 2 3 3 Expanded in metazoans Other Bub 1 1 2 2 "1 worm, expanded in fly/human" Other Bud32 1 1 1 1 1 in all species Other CAMKK ELM 3 0 0 0 Specific to Yeast Other CAMKK Meta 0 1 1 2 Related to fungal Elm family kinases Other CDC7 1 0 2 1 No Worm Other CK2 2 1 1 2 1 "Expanded in Human, Yeast" Other HAL 9 0 0 0 Specific to Yeast Other Haspin 0 12 1 1 Expanded in Worm Other IKK 0 0 2 4 Fly+Human Other IRE 1 1 1 2 Expanded in Human Other MOS 0 0 1 1 Fly+Human Other Nak 4 2 3 4 1 Many in all species Other Nek 1 4 2 11 4 Expanded in metazoans Other NKF1 0 1 2 3 "1 worm, expanded in fly/human" Other NKF2 0 1 1 1 1 per metazoan Other NKF3 0 0 0 2 Specific to Human Other NKF4 0 0 0 2 Specific to Human Other NKF5 0 0 0 2 Specific to Human Other NRBP 0 1 1 2 1 fly/worm expanded in human Other PEK GCN2 1 1 1 1 1 in all species Other PEK PEK 0 2 1 1 1 per metazoan (second worm hit probably a psu) Other PEK Unclassified 0 0 0 2 1 Leftover group Other PLK 1 3 2 4 4 Expanded in metazoans Other RAN 3 0 0 0 Specific to Yeast Other SCY1 1 2 4 3 1 "1 yeast, expanded in metazoans" Other SLOB 0 0 2 1 Fly+Human Other TBCK 0 1 1 1 1 fly/worm expanded in human Other TLK 0 1 1 2 3 1 fly/worm expanded in human Other TOPK 0 0 1 1 Fly+Human Other TTK 1 0 1 1 No Worm Other ULK 1 2 3 5 Expanded in metazoans Other Unique 4 10 1 7 Leftover group Other VPS15 1 1 1 1 1 in all species Other WEE 1 3 2 3 3 "1 yeast, expanded in metazoans" Other Wnk 0 1 1 4 1 fly/worm expanded in human Other Worm1 0 2 0 0 Specific to Worm Other Worm2 0 3 0 0 Specific to Worm Other Worm3 0 2 0 0 Specific to Worm Other Worm4 0 2 0 0 Specific to Worm Other Worm5 0 3 0 0 Specific to Worm RGC RGC 0 27 6 5 3 Several per metazoan STE Ste11 4 2 2 8 Many in all species STE Ste20 FRAY 0 1 1 2 1 fly/worm expanded in human STE Ste20 KHS 0 1 1 4 1 fly/worm expanded in human STE Ste20 MSN 0 1 1 4 1 fly/worm expanded in human STE Ste20 MST 1 1 1 2 Expanded in Human STE Ste20 NinaC 0 0 1 2 Fly+Human STE Ste20 PAKA 3 2 2 3 1 Many in all species STE Ste20 PAKB 0 1 1 3 1 fly/worm expanded in human STE Ste20 SLK 0 1 1 2 1 fly/worm expanded in human STE Ste20 STLK 0 2 1 2 2 "1 fly, expanded in worm/human" STE Ste20 TAO 0 1 1 3 1 fly/worm expanded in human STE Ste20 YSK 2 1 1 3 1 "Expanded in Yeast, Human" STE Ste7 4 10 4 7 2 Many in all species STE Unique 0 1 1 3 Leftover group TK Abl 0 1 1 2 1 fly/worm expanded in human TK Ack 0 2 2 2 Several per metazoan TK Alk 0 1 1 2 "1 fly, expanded in worm/human" TK Axl 0 0 0 3 1 Specific to Human TK CCK4 0 0 1 1 Fly+Human TK Csk 0 1 1 2 1 fly/worm expanded in human TK DDR 0 2 1 2 "1 fly, expanded in worm/human" TK EGFR 0 1 1 4 1 fly/worm expanded in human TK Eph 0 1 1 14 1 fly/worm expanded in human TK Fak 0 1 1 2 1 fly/worm expanded in human TK Fer 0 42 1 2 1 Expanded in Worm TK FGFR 0 1 2 4 "1 worm, expanded in fly/human" TK InsR 0 1 1 3 1 fly/worm expanded in human TK JakA 0 0 1 4 Fly+Human TK JakB 0 0 1 4 Fly+Human TK Kin16 0 16 0 0 Specific to Worm TK Kin6 0 5 0 0 Specific to Worm TK Lmr 0 0 0 3 Specific to Human TK Met 0 2 0 2 Worm+Human TK Musk 0 0 1 1 Fly+Human TK PDGFR/VEGFR 0 0 2 8 1 Fly+Human TK Ret 0 0 1 1 Fly+Human TK Ror 0 1 1 2 1 fly/worm expanded in human TK Ryk 0 1 3 1 1 Expanded in Fly TK Sev 0 0 1 1 Fly+Human TK Src 0 3 2 11 1 Several per metazoan TK Syk 0 0 1 2 Fly+Human TK Tec 0 0 1 5 Fly+Human TK Tie 0 0 0 2 Specific to Human TK Trk 0 1 0 3 Worm+Human TK Unique 0 7 4 1 Leftover group TKL IRAK 0 1 1 4 1 fly/worm expanded in human TKL LISK LIMK 0 0 1 2 1 Fly+Human TKL LISK TESK 0 0 1 2 Fly+Human TKL LRRK 0 1 1 2 1 fly/worm expanded in human TKL MLK HH498 0 1 0 1 Worm+Human TKL MLK ILK 0 1 1 1 1 per metazoan TKL MLK LZK 0 1 1 2 1 fly/worm expanded in human TKL MLK MLK 0 2 1 5 "Expanded in Human, Worm" TKL MLK TAK1 0 2 3 1 "Expanded in Fly, Worm" TKL RAF 0 3 2 5 3 Several per metazoan TKL RIPK 0 0 0 5 Specific to Human TKL STKR Type1 0 2 3 7 2 Several per metazoan TKL STKR Type2 0 1 2 5 "1 worm, expanded in fly/human" TKL Unique 0 0 0 1 Leftover group