# genes # domains Domain Name Pfam Symbol Function Class 44 44 Protein kinase C terminal domain pkinaseC Accessory domain 30 254 Immunoglobulin domain ig "Extracellular, protein interactions" 28 194 Fibronectin type III domain fn3 "Extracellular, protein interactions" 27 28 SH3 domain SH3 Adaptor: binds proline-rich motifs 25 27 SH2 domain SH2 Adaptor: Binds phospho-tyrosine 23 33 Diacylglycerol binding (C1) domain DAG_PE-binding Phopholipid binding (DAG) 23 25 Calmodulin binding motif Calcium Binding 23 22 PH domain PH Signaling; phospholipid binding 15 16 Sterile alpha motif SAM Protein interaction (dimerization) 14 14 Ephrin receptor ligand binding domain EPH_lbd Ligand Binding 12 12 CNH domain CNH Cytoskeletal? 11 11 Activin receptor Activin_recp Ligand Binding 10 27 HEAT/Armadillo repeats "HEAT, HEAT_PBS, Armadillo_seg" Protein Interaction 9 59 Ankyrin repeat ank Protein interaction 9 9 "p21-Rho-binding domain (PBD, CRIB)" PBD GTPase interaction 8 15 Bromodomain bromodomain Acetyl-lysine (chromatin) binding domain 7 21 Furin-like cysteine rich region Furin-like Receptor oligomerization? 7 14 Receptor L domain Recep_L_domain Ligand Binding 7 8 Ubiquitin-associated domain A UBA Ubiquitination 7 7 Regulator of G protein signaling domain RGS GTPase interaction 7 7 PDZ/DHR/GLGF domain PDZ Membrane targetting 6 6 FATC domain FATC Accessory domain for PI34K domain protein kinases 6 6 FAT domain FAT Accessory domain for PI34K domain protein kinases 6 6 Phosphatidyl inositol kinase PI34K Catalytic 6 6 Alpha Kinase MHCK_EF2_kinase Catalytic domain 6 6 C2 domain C2 Phopholipid binding? 6 6 Death domain Death Protein interaction (dimerization) 5 30 Leucine Rich Repeat "LRR, LRRNT, LRRCT" "Ligand binding, protein interactino" 5 13 HR1 repeat HR1 GTPase interaction 5 5 HSP90-like ATPase HATPase_c Catalytic 5 5 ABC1 family ABC1 Catalytic domain 5 5 Guanylate cyclase catalytic domain guanylate_cyc Catalytic: cGMP creation 5 5 ANF receptor ANF_receptor Ligand Binding 5 5 Kinase associated domain 1 KA1 Unknown 4 5 Rho Guanine Exchange Factor domain RhoGEF GTPase interaction 4 4 PX domain PX Binding to phosphoinositites and SH3 domains 4 4 BTK motif BTK Signaling 3 8 B-box Zn finger zf-B_box Unknown 3 6 IQ calmodulin binding motif IQ Calcium Binding 3 6 POLO box duplicated region POLO_box Unknown 3 6 Bacterial_PQQ Bacterial_PQQ Unknown 3 3 Octicosapeptide repeat (aka PB1 domain) OPR Ca binding 3 3 RIO1 domain RIO1 Catalytic 3 3 Frizzled domain Fz Extracellular 3 3 Raf-like Ras-binding domain RBD GTPase interaction 2 11 Regulator of Chromosomal Condensation 1 RCC1 Unknown 2 8 IPT/TIG domain TIG Extracellular 2 7 EGF-like domain EGF Extracellular 2 5 Kelch domain Kelch Unknown 2 4 Cyclic nucleotide-binding domain cNMP_binding cNMP binding 2 4 Cofilin/tropomyosin-type actin-binding protein cofilin_ADF Cytoskeletal 2 4 Doublecortin domain DCX Cytoskeletal 2 4 LIM domain LIM Protein interaction 2 2 Myosin head (motor domain) myosin_head Cytoskeletal 2 2 Fes/CIP4 homology domain FCH Cytoskeletal 2 2 Semaphorin domain Sema Extracellular 2 2 F5/8 type C domain F5_F8_type_C Extracellular 2 2 Plexin repeat psi Extracellular? 2 2 Focal Adhesion Targeting Region Focal_AT Focal Adhesion binding 2 2 Ion transport protein ion_trans Ion Transport 2 2 Kringle domain Kringle Mixed 1 6 Spectrin repeat Spectrin Cytoskeletal 1 4 "WD domain, G-beta repeat" WD40 GTPase interaction?? 1 3 PAS domain PAS Small-molecule sensor 1 2 Cadherin domain cadherin Ligand Binding 1 2 L27 domain L27 Protein Interaction 1 2 Double-stranded RNA binding motif DSRM RNA interaction 1 1 Caspase recruitment domain CARD Apoptosis 1 1 Guanylate kinase Guanylate_kin Catalytic 1 1 DnaJ domain DnaJ Chaperone 1 1 1 Hsp20/alpha crystallin family HSP20 Chaperone 1 1 MAM domain MAM Extracellular? 1 1 TBC domain TBC GTPase interaction 1 1 RhoGAP domain RhoGAP GTPase interaction 1 1 FHA domain FHA Nuclear signaling 1 1 TRP repeat TPR Protein interaction domain 1 1 ubiquitin ubiquitin Protein interaction? 1 1 RING finger zf-C3HC4 Protein interaction? 1 1 RNA recognition motif rrm RNA interaction 1 1 Tudor domain Tudor RNA interaction 1 1 Rhodanese-like domain Rhodanese Unknown 1 1 KOW motif KOW Unknown 1 1 Rhabdovirus spike glycoprotein Rhabdo_glycop Unknown