MEKK15_Hsap_MEKK15                  MQLLQSSWQGDL------------------------------------------------
MAP3K7_Hsap_ASK                     MESGGGNAPAGA------------------------------------------------
MAP3K6_Hsap_ASK                     MAGPCPRSGA-ER-----------------------------------------------
MAP3K5_Hsap_ASK                     MSTEADEGITF-S--V------------PPFA-------------------------PSG
MAP3K4_Hsap_MEKK4                   MREAAAALVPP-------------------PA-------------------------F--
MAP3K3_Hsap_MEKK2                   MDEQEALNSIMN---D----------------------LV--A-L-----------Q---
MAP3K2_Hsap_MEKK2                   MDDQQALNSIMQ---D----------------------LA--V-L-----------H---
MAP3K1_Hsap_MEKK1                   MAAAAGNRASSS---G----------------------F---P-G-----------AR--
MEKK15_Mmus_MEKK15                  MNKNRLIHDFLG---VVSRGDVECICGLIPEVHSVLGNLDFQH-P-----------Q---
MAP3K7_Mmus_ASK                     MEGGGGSGGGGGP--V------------PA------------------------------
MAP3K6_Mmus_ASK                     MAGPCPGAGVLER-----------------------------------------------
MAP3K5_Mmus_ASK                     MGTEAGEGITF-S--V------------PPFA-------------------------SVG
MAP3K4_Mmus_MEKK4                   MRDAIAEPVPP-------------------PA-------------------------L--
MAP3K3_Mmus_MEKK2                   MDEQEALDSIMK---D----------------------LV--A-L-----------Q---
MAP3K2_Mmus_MEKK2                   MDDQQALNSIMQ---D----------------------LA--V-L-----------H---
MAP3K1_Mmus_MEKK1                   MAAAAGDRASSS---G----------------------F---P-G-----------AA--
nsy-1_Cele_ASK                      MSQNNKRQVQHNH--E------------M-------------------------------
B0414.7_Cele_MEKK4                  MSSNQYKRIKRC---K------------S---------MP----TIDDETVGEA------
STE11_Scer_STE11-Unclassified       MEQTQTAEGTDL---L------------I-------G-----D-E-----------K---
SSK22_Scer_STE11-Unclassified       MMMDILNTQQQK---A------------A-------------E-G-----------G---
SSK2_Scer_STE11-Unclassified        MSHSDYFNYKPY---G----------------------------------------D---
CDC15_Scer_CDC15                    MNSMADTDRVNL---T--------------------------------------------
BCK1_Scer_STE11-Unclassified        MPFLRKIAGTAH---T-----------------------H--------------------
Pk92B_Dmel_ASK                      MDTAVGDHLEDR---Q------------C-------------------------------
Mekk1_Dmel_MEKK4                    MSNRRRVRTIDYLALQ------------Q-------------S-L-----------R---
DDB0229877_Ddis_CDC15               MDTIKET-----------------------------------------------------
DDB0229896_Ddis_CDC15               MSKKEPEE-I--------------------------------------------------
DDB0229915_Ddis_CDC15               MIEINNNHNN-GN-----------------------------------------------
DDB0229971_Ddis_CDC15               MNIKSELNYSNGS-----------------------------------------------
DDB0231212_Ddis_CDC15               MSQPSLLNQL--------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   MSWLNNPSQ-NF---V------------D-------------P-F-----------I---
11359_Tthe_STE11-Unclassified       MGICGAKMKI-V---A------------E-------------P-V-----------Q---
15684_Tthe_STE11-Unclassified       MGSSFSNSCAKS---K------------Q---------------K-----------K---
18758_Tthe_STE11-Unclassified       MKNQEFNNSAQK---S------------S---------------T---------------
23105_Tthe_STE11-Unclassified       MRTYKFIIDQKI---D------------E-------------N-L-----------K---
29763_Tthe_STE11-Unclassified       MGNNLLNACKNT---S------------A-------------P-T-----------D---
4322_Tthe_CDC15                     MLRRVIQDK---------------------------------------------------
6622_Tthe_STE11-Unclassified        MSMFDKEYDKK----G------------F-------------D-I-----------K---
7147_Tthe_STE11-Unclassified        MGCGASNHKGEV---A------------E-------------P-R-----------S---
MEKK1_Spur_MEKK1                    MAIAHLKLEKAH---L----------------------L-----------------EP--
MEKK2_Spur_MEKK2                    MRFQRALEIITL---T----------------------LA--P-A-----------A---
MEKK4_Spur_MEKK4                    TTPTQQQQLVR-------------------------------------------------
ASK_Spur_ASK                        AEDALNNACRLVN-----------------------------------------------
MEKK15_Spur_MEKK15                  MISSTDRSLSTN------------------------------------------------
CC1G_00852_Ccin_CDC15               MAAALVSSAKVP---------------------------Q--V-----------------
CC1G_05008_Ccin_CDC15               MSTPSRPSSM--------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  MGSVDLRGQLPF---P--------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  MDSRPASTLRT----L-----------------------Q--T-W---------------
CC1G_13687_Ccin_STE11-Unclassified  MRKHNPTLYTLS---E------------R-------------D-S-----------D---
CC1G_10513_Ccin_STE11-Unclassified  MSEDVRNGKIHG---R-----------------------K--Y-F---------------
AqueK224_Aque_ASK                   MSSKVKLQRSVRE--Q------------Q-------------------------------
AqueK225_Aque_MEKK1                 MEGAKQQKDVPQP-----------------------------------------------
AqueK226_Aque_MEKK15                MNGGTGKRTTYH---K----------------------IAYDV-L---------------
AqueK227_Aque_MEKK2                 MADGQLPSIEAGD--R------------S-------------------------------
AqueK228_Aque_MEKK4                 MAEGEGEEESYF---P------------D---------HV--VEGIDEEASGETDDK---
MEKK2-p1_a_Smoe_MEKK2-plant1        MGEQST------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        MGEQST------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      MGHNLSPTTLRR------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    MSRHSSASHFH-------------------------------------------------
NPK1-1_Smoe_NPK1                    MSRHSSASHFH-------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      MEKDFSHSGSSG---R-----------------------R--R-L---------------
STE11-p2_j_Smoe_STE11-plant1        MKC---------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      MEKDFSHSGSSG---R-----------------------R--R-L---------------
STE11-p2_g_Smoe_STE11-plant2        MCSN--------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        METLEIPL----------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        MFLTFARSACS-------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      MLSATPRSLQST------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      MC----------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        MADRV-------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        MADRV-------------------------------------------------------
GK076_Glam_CDC15                    MKRDKLLLNG--------------------------------------------------
GK077_Glam_CDC15                    MQTDNPLT----------------------------------------------------
GK078_Glam_STE11-Unclassified       MGVGASSVP-G-------------------------------------------------


MEKK15_Hsap_MEKK15                  ------------------------------------------------------------
MAP3K7_Hsap_ASK                     ------------------L--G--------A-ASESP-----------------------
MAP3K6_Hsap_ASK                     ------------------A--G--------S-CWQDP-----------------------
MAP3K5_Hsap_ASK                     FCTIPEGGICRRGG-AAAVGEG--------E-EH--------------------------
MAP3K4_Hsap_MEKK4                   -AVTPA----------A--AME--------E-P---------------------------
MAP3K3_Hsap_MEKK2                   --------------------------------MNRRHR----------------------
MAP3K2_Hsap_MEKK2                   --------------------------------KASRPA----------------------
MAP3K1_Hsap_MEKK1                   -ATSPE--------------AGG---GGGALKASSAPAA---------------------
MEKK15_Mmus_MEKK15                  --------------------------------TGNTPLI---------------------
MAP3K7_Mmus_ASK                     ----------------EAP--E--------E-AGEPP-----------------------
MAP3K6_Mmus_ASK                     ------------------A--G--------S-CWQDP-----------------------
MAP3K5_Mmus_ASK                     FCTIPEGGSCRRGGGAATAAEG--------E-PSLQP-----------------------
MAP3K4_Mmus_MEKK4                   -ADTPA----------A--AME--------E-L---------------------------
MAP3K3_Mmus_MEKK2                   --------------------------------MSRRTR----------------------
MAP3K2_Mmus_MEKK2                   --------------------------------KASRPA----------------------
MAP3K1_Mmus_MEKK1                   -AASPE--------------AGGGGGGGGALQGSGAPAA---------------------
nsy-1_Cele_ASK                      --------------------S-----------NDVCP-----------------------
B0414.7_Cele_MEKK4                  -------------------------------------------------------VRKTI
STE11_Scer_STE11-Unclassified       --------------------------------TNDLP-----------------------
SSK22_Scer_STE11-Unclassified       --------------------------------RVLAPHT---------------------
SSK2_Scer_STE11-Unclassified        --------------------------------STEKPS----------------------
CDC15_Scer_CDC15                    ------------------------------------P-----------------------
BCK1_Scer_STE11-Unclassified        ---S--------------------------------------------------------
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    --------------------------------LQKTPAA---------------------
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       --------------------------------TGKTPE----------------------
15684_Tthe_STE11-Unclassified       --------------------------------ENKS------------------------
18758_Tthe_STE11-Unclassified       ---------------------------------YKLPIK---------------------
23105_Tthe_STE11-Unclassified       --------------------------------VLKKEEA---------------------
29763_Tthe_STE11-Unclassified       --------------------------------QND-------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        --------------------------------QIQSPIL---------------------
7147_Tthe_STE11-Unclassified        --------------------------------RF-IFL----------------------
MEKK1_Spur_MEKK1                    -LVVPF------------------------------------------------------
MEKK2_Spur_MEKK2                    --------------------------------VSAHSA----------------------
MEKK4_Spur_MEKK4                    ------------------------------------------------------------
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  --A---------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  -----D--------------INDDDENVSWQHEEHDPVP---------------------
CC1G_10513_Ccin_STE11-Unclassified  --VA--------------------------------------------------------
AqueK224_Aque_ASK                   --------------------------------VIVTV-----------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                --------------------------------QSRRPQS---------------------
AqueK227_Aque_MEKK2                 ------------------V--R--------R-RVDED-----------------------
AqueK228_Aque_MEKK4                 --------------------------------LSSLPVDSTSEEEEEESGSYDEGLTGST
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ---------------------------------GE-------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------PGF---------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------PDP---------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ----------------N--ATS--------EHI---------------------------


MEKK15_Hsap_MEKK15                  ------------------------------------------------------------
MAP3K7_Hsap_ASK                     -----------QCPPP-PGVEGA-------AGP---------------------AEPDGA
MAP3K6_Hsap_ASK                     ---L--------------------------------------------------AVALSR
MAP3K5_Hsap_ASK                     -----------QLPP---PPPGSFWNVESAAAPGI-------------------GCPAA-
MAP3K4_Hsap_MEKK4                   -----------PPPPPPPPPPPE---PETESEPECCLAARQEGTLGDSACKSPESDLEDF
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   ------------------------------------------------------------
MEKK15_Mmus_MEKK15                  ------------------------------------------------------------
MAP3K7_Mmus_ASK                     -----------QGRLP-PGPEGA-------AGL---------------------AEPEST
MAP3K6_Mmus_ASK                     ---L--------------------------------------------------AEALSR
MAP3K5_Mmus_ASK                     ---L-------LVPPP-PPPPGSFWNVESAAAPGT-------------------SCPTT-
MAP3K4_Mmus_MEKK4                   -----------RPA-PPPQPEPD---P------ECCPAARQECMLGESARKSMESDPEDF
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   ------------------------------------------------------------
nsy-1_Cele_ASK                      ---L-------PLPPRGAPPPTAYHA----SRM---------------------AA----
B0414.7_Cele_MEKK4                  MKKVA--------------------------------------------------TRMN-
STE11_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK22_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK2_Scer_STE11-Unclassified        ------------------------------------------------------------
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ------------------------------------------------------------
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    ------------------------------------------------------------
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               -------------------G----------------------------------------
DDB0229971_Ddis_CDC15               -------------------NDSD-------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       ------------------------------------------------------------
18758_Tthe_STE11-Unclassified       ------------------------------------------------------------
23105_Tthe_STE11-Unclassified       ------------------------------------------------------------
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        ------------------------------------------------------------
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    ------------------------------------------------------------
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10513_Ccin_STE11-Unclassified  ------------------------------------------------------------
AqueK224_Aque_ASK                   ---I-------PDT----------------------------------------------
AqueK225_Aque_MEKK1                 -----------------PVQPIS-------------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 ---IHRHLIAGFHPI---DPVG--------------------------------------
AqueK228_Aque_MEKK4                 PPSNS---------------------------------------------------RLHK
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       -----------DG-SLLPVP---------QLER---------------------------


MEKK15_Hsap_MEKK15                  ------------------------------------------------------------
MAP3K7_Hsap_ASK                     -AEGAAGGSG---EGESGGGPRR-------------------ALRAV-------------
MAP3K6_Hsap_ASK                     -GRQLAAPPG---RG---CARSR-------------------PLSVV-------------
MAP3K5_Hsap_ASK                     -TSSSSATRG---RGSSVGGGSR-------------------RTTVA-------------
MAP3K4_Hsap_MEKK4                   -S-DETN--TENLYGTSPPSTPR-------------------QMKR--------------
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   ------------------------------------------------------------
MEKK15_Mmus_MEKK15                  ------------------------------------------------------------
MAP3K7_Mmus_ASK                     -G-DAA--GG---EAEGGRGPRR-------------------ALRAV-------------
MAP3K6_Mmus_ASK                     -GRSSPAVTG---RG---CARSR-------------------PLSVV-------------
MAP3K5_Mmus_ASK                     -APGSSATRG---RGNSGSGGGR-------------------RTTVA-------------
MAP3K4_Mmus_MEKK4                   -S-DETN--TETLYGTSPPSTPR-------------------QMKR--------------
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   ------------------------------------------------------------
nsy-1_Cele_ASK                      -TSSSTNGSF---EKSAIPGNAR-------------------KLHVV-------------
B0414.7_Cele_MEKK4                  TSK-----R--------EYMGRR-------------------SLGVA-------------
STE11_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK22_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK2_Scer_STE11-Unclassified        ------------------------------------------------------------
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ------------------------------------------------------------
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    ------------------------------------------------------------
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       ------------------------------------------------------------
18758_Tthe_STE11-Unclassified       ------------------------------------------------------------
23105_Tthe_STE11-Unclassified       ------------------------------------------------------------
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        ------------------------------------------------------------
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    ------------------------------------------------------------
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10513_Ccin_STE11-Unclassified  ------------------------------------------------------------
AqueK224_Aque_ASK                   -----REGR---------------------------------------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 ---------G---G----------------------------------------------
AqueK228_Aque_MEKK4                 MSR-----R---------GHKYKTSRKIMSSSSENQSPYRVKDITRAKSADWSESVSTPS
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  ------------------------------------------------------------
MAP3K7_Hsap_ASK                     ----------------------YVRSESSQGGAA--G--GPEAGA---------------
MAP3K6_Hsap_ASK                     ----------------------YVLTREPQPGLEPREGTEAEPLP---------------
MAP3K5_Hsap_ASK                     ----------------------YVINEASQGQLV-----VAESEA---------------
MAP3K4_Hsap_MEKK4                   ------------------------MSTKHQRNNVG------RPASRSNLKEKMNAPNQPP
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   ------------------------------------------------------------
MEKK15_Mmus_MEKK15                  ------------------------------------------------------------
MAP3K7_Mmus_ASK                     ----------------------YVRSESSQGAAA-GG--GPEAGA---------------
MAP3K6_Mmus_ASK                     ----------------------YVLTREPGLGVEPGSGTEAEPLP---------------
MAP3K5_Mmus_ASK                     ----------------------YVINEASQGQLV-----VAESEA---------------
MAP3K4_Mmus_MEKK4                   ------------------------LSAKHQRNSAG------RPASRSNLKEKMNTPSQSP
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   ------------------------------------------------------------
nsy-1_Cele_ASK                      ----------------------IVIDQKVQKNLRV------REMA---------------
B0414.7_Cele_MEKK4                  ----------------------TVSTK---------------------------------
STE11_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK22_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK2_Scer_STE11-Unclassified        ------------------------------------------------------------
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ------------------------------------------------------------
Pk92B_Dmel_ASK                      --------------------------------------------A---------------
Mekk1_Dmel_MEKK4                    ------------------------------------------------------------
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       ------------------------------------------------------------
18758_Tthe_STE11-Unclassified       ------------------------------------------------------------
23105_Tthe_STE11-Unclassified       ------------------------------------------------------------
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        ------------------------------------------------------------
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    ---------------------------LRQKNSLN------RVVTRNSLKMEMEALIQKI
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10513_Ccin_STE11-Unclassified  ------------------------------------------------------------
AqueK224_Aque_ASK                   -------------------------------------------KC---------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 -------------------------------------GHNMKPP----------------
AqueK228_Aque_MEKK4                 DSLIHKRYSLTGEGEEISSELCQVSLC---------------------------------
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  ------------------------------------------------------------
MAP3K7_Hsap_ASK                     RQCL----------------------------LRACEAE---------------------
MAP3K6_Hsap_ASK                     LRCL----------------------------REACAQVPRPR-----------------
MAP3K5_Hsap_ASK                     LQSL----------------------------REACETV---------------------
MAP3K4_Hsap_MEKK4                   ----HKD---TGKTVENVEEYSYKQEKKIRAALR-------TTERDRKKNVQCSFMLDSV
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   ------------------------------------------------------------
MEKK15_Mmus_MEKK15                  ------------------------------------------------------------
MAP3K7_Mmus_ASK                     LKCL----------------------------LRACEAE---------------------
MAP3K6_Mmus_ASK                     LRCL----------------------------REACAQLQGTR-----------------
MAP3K5_Mmus_ASK                     LQSL----------------------------REACEAV---------------------
MAP3K4_Mmus_MEKK4                   ----HKD---LGKGVETVEEYSYKQEKKIRATLR-------TTERDHKKNAQCSFMLDSV
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   ------------------------------------------------------------
nsy-1_Cele_ASK                      LKDV----------------------------QKVADTL---------------------
B0414.7_Cele_MEKK4                  -------------------IKRKKS---KTERDRDMYDDMYDDEGYAASPTSSS------
STE11_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK22_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK2_Scer_STE11-Unclassified        ------------------------------------------------------------
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ------------------------------------------------------------
Pk92B_Dmel_ASK                      LEEI----------------------------KQAVQSA---------------------
Mekk1_Dmel_MEKK4                    ------------------------------------------------------------
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               I-----------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       ------------------------------------------------------------
18758_Tthe_STE11-Unclassified       ------------------------------------------------------------
23105_Tthe_STE11-Unclassified       ------------------------------------------------------------
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        ------------------------------------------------------------
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    IQEIIQDLMNFGQSAQNTKQKLHQRKMRSIHLDR-------TSEREFKQKAIT-----YD
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10513_Ccin_STE11-Unclassified  ------------------------------------------------------------
AqueK224_Aque_ASK                   FNVL----------------------------QEVANEL---------------------
AqueK225_Aque_MEKK1                 LR----------------------------------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 -------------------DKKRKEKSRQMERNVK---SAINHPEMSTSPSSTANYTNTE
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  ------------------------------------------------------------
MAP3K7_Hsap_ASK                     -----------------------------------------GAHLT--------------
MAP3K6_Hsap_ASK                     ----------------------------------------PPPQLR--------------
MAP3K5_Hsap_ASK                     -----------------------------------------GATLE--------------
MAP3K4_Hsap_MEKK4                   GGSLPKKSIPDVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRT--------------
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   ------------A--AGL-L----------------------------------------
MEKK15_Mmus_MEKK15                  ------------TAAEEN-LAEVVEILLEGGADITLC-----NYSNQTALHVANGDIQRQ
MAP3K7_Mmus_ASK                     -----------------------------------------GAHLT--------------
MAP3K6_Mmus_ASK                     ----------------------------------------PPPQLR--------------
MAP3K5_Mmus_ASK                     -----------------------------------------GATLE--------------
MAP3K4_Mmus_MEKK4                   AGSLPKKSIPDVDLNKPYLSLGCSNAKLPVSMPMPIARTARQTSRT--------------
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   -----------GA--AGL-L----------------------------------------
nsy-1_Cele_ASK                      -----------------------------------------NVNLT--------------
B0414.7_Cele_MEKK4                  ---------------------------SCTYRCIPILERSNRNSQNYLP-----------
STE11_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK22_Scer_STE11-Unclassified       ------------I--SSKLV----------------KR----------------------
SSK2_Scer_STE11-Unclassified        ---------------SSK-M----------------RQ----------------------
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ------------------------------------------------------------
Pk92B_Dmel_ASK                      -----------------------------------------GANFQ--------------
Mekk1_Dmel_MEKK4                    ----------------T--T----------------------------------------
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       ------------------------------------------------------------
18758_Tthe_STE11-Unclassified       ------------K--NS--M----------------GSTIGCWI----------------
23105_Tthe_STE11-Unclassified       ----------------K--L----------------H-----------------------
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        ----------------K--L----------------Y-----------------------
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    GSELH-VPLTPTHVFRP---------------------------FD--------------
ASK_Spur_ASK                        -----------------------------------------NVTLI--------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  ------------G--PS-NV----------------------------------------
CC1G_10513_Ccin_STE11-Unclassified  ------------------------------------------------------------
AqueK224_Aque_ASK                   -----------------------------------------DYIVE--------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ------------A--VDS-L----------------------------------------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 PPRPSFSSPSPSNPPYPVLAHSHSSPPPSSHPPPSHPPSHPPPSHSPLPPPSSPPALPPP
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ----------------F--L----------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  -----------------------EQVQHLLASEEFLDINFPNQHGLTPLMLA--------
MAP3K7_Hsap_ASK                     -------------------------------------------------SVP--------
MAP3K6_Hsap_ASK                     -------------------------------------------------SLP--------
MAP3K5_Hsap_ASK                     -------------------------------------------------TLH--------
MAP3K4_Hsap_MEKK4                   -------------------------------------------------DC--------P
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   ------R---------EAGSGGRERADWRRRQLRKVRSVELDQLPEQPLFL---------
MEKK15_Mmus_MEKK15                  LLAGKGIQAPQMQLLRSSWLGDLKQLRHLLACEEFLDINFPNSHGLTPLMLA--------
MAP3K7_Mmus_ASK                     -------------------------------------------------SVP--------
MAP3K6_Mmus_ASK                     -------------------------------------------------SLP--------
MAP3K5_Mmus_ASK                     -------------------------------------------------TLH--------
MAP3K4_Mmus_MEKK4                   -------------------------------------------------DC--------P
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   ------R---------EPGSAGRERADWRRRQLRKVRSVELDQLPEQPLFL---------
nsy-1_Cele_ASK                      -------------------------------------------------RID--------
B0414.7_Cele_MEKK4                  --------SAESSSSDSNDRVISHP--------N--------------------------
STE11_Scer_STE11-Unclassified       -------------------------------------------------FVQ--------
SSK22_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK2_Scer_STE11-Unclassified        ------------------------------------------------------------
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ----------------------R------SDSNSS-------------------------
Pk92B_Dmel_ASK                      -------------------------------------------------RVQ--------
Mekk1_Dmel_MEKK4                    ------------------------------------------------------------
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       ------------------------------------------------------------
18758_Tthe_STE11-Unclassified       ------------------------------------------------------------
23105_Tthe_STE11-Unclassified       ------------------------------------------------------------
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        ------------------------------------------------------------
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    -------------------------------------------------SLPSPNLKIDS
ASK_Spur_ASK                        -------------------------------------------------KVN--------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10513_Ccin_STE11-Unclassified  ----------------NRGSDSE------NDSDDDNDKPPIFNSYHYSAPY---------
AqueK224_Aque_ASK                   -------------------------------------------------RIA--------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ------LEAAEIGDDRK-------------LMEL---------VSKYRTIIN--------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 SPSHPPPPSYSPSSPSPLSYNVPPPSSYPLPPPNQSPSVDTSLYPPPIDPHY--------
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  VRDVDLFESLDM----------------LTVYKPVEVLSQ-LLRHHADPKLCDFSGKSAI
MAP3K7_Hsap_ASK                     FGELDFGETAVL----------------DAFYDADVAVVD-MSDVSRQPSLF--------
MAP3K6_Hsap_ASK                     FGTLELGDTAAL----------------DAFYNADVVVLE-VSSSLVQPSLF--------
MAP3K5_Hsap_ASK                     FGKLDFGETTVL----------------DRFYNADIAVVE-MSDAFRQPSLF--------
MAP3K4_Hsap_MEKK4                   ADRLKFFETLR-------------------------LLLK-LTSVSKKKDRE--------
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   ------------------------------------------------------------
MEKK15_Mmus_MEKK15                  VRDVDLFESLDL----------------LTAYRPDEVLAE-LLRHHADPKLCDFSGKSAI
MAP3K7_Mmus_ASK                     FGELDFGETAVL----------------DAFYDADVAIVD-MSDISRQPSLF--------
MAP3K6_Mmus_ASK                     FATLALGDTAAL----------------DSFYNADVVVLE-VSSSLAQPSLF--------
MAP3K5_Mmus_ASK                     FGKLDFGETAVL----------------DRFYNADIAVVE-MSDAFRQPSLF--------
MAP3K4_Mmus_MEKK4                   ADRLKFFETLR-------------------------LLLK-LTSVSKKKDRE--------
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   ------------------------------------------------------------
nsy-1_Cele_ASK                      FDKLDFGETETL----------------DLFYNADVALVD-VTVTHQQPSLC--------
B0414.7_Cele_MEKK4                  ----------------------------------------------HRPILL--------
STE11_Scer_STE11-Unclassified       LFLEEIGCTQYL----------------DSFIQCNLVTEE-E-IKYLDKDIL--------
SSK22_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK2_Scer_STE11-Unclassified        ------------------------------------------------------------
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ------------------------------------------------------------
Pk92B_Dmel_ASK                      FERLDFGETNVL----------------ETFYNADVAIID-LSILTQQRPLS--------
Mekk1_Dmel_MEKK4                    ------------------------------------------------------------
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ----YNEY--------------------------GG------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       ------------------------------------------------------------
18758_Tthe_STE11-Unclassified       -------------------------------S----------------------------
23105_Tthe_STE11-Unclassified       -------------------------------Q----------------------------
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        -------------------------------Q----------------------------
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    SERVDFHRTFS-------------------------ALIR-MGSAKKENSQE--------
ASK_Spur_ASK                        FDRLDFGETKVL----------------DRFYAADIVVVD-VSVIVQQRTLF--------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10513_Ccin_STE11-Unclassified  ------------------------------------------------------------
AqueK224_Aque_ASK                   FEKLDFGETDAL----------------DKFYSSNVAVAD-VTDRACQAKLF--------
AqueK225_Aque_MEKK1                 ---ILFAE--------------------------DHQWLK----------VD--------
AqueK226_Aque_MEKK15                LKCVSSGDTALI----------------TAARNGHSNIVEYLMKSGADPTLQ--------
AqueK227_Aque_MEKK2                 ----SLGHTRT------------------------------ISGLSTQNELD--------
AqueK228_Aque_MEKK4                 ---LPTGDSPVLYPLPHLSPETYSSKLSSSPYPSKLGKVG-SPNPMLSPGIP--------
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ---DKLG-----------------------------LEAA-VD-----------------


MEKK15_Hsap_MEKK15                  HYVSQIESSKKQQLLDILMS--------SM------------------------------
MAP3K7_Hsap_ASK                     ------------------------------------------------------------
MAP3K6_Hsap_ASK                     ------------------------------------------------------------
MAP3K5_Hsap_ASK                     ------------------------------------------------------------
MAP3K4_Hsap_MEKK4                   ------------------------------------------------------------
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   -------------------A-ASPPASSTSPSPEPA------------------------
MEKK15_Mmus_MEKK15                  HYVSQIESWRKQQLLDILMD--------SM------------------------------
MAP3K7_Mmus_ASK                     ------------------------------------------------------------
MAP3K6_Mmus_ASK                     ------------------------------------------------------------
MAP3K5_Mmus_ASK                     ------------------------------------------------------------
MAP3K4_Mmus_MEKK4                   ------------------------------------------------------------
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   -------------------AAASPPCPSTSPSPEPA------------------------
nsy-1_Cele_ASK                      ------------------------------------------------------------
B0414.7_Cele_MEKK4                  ------------------------------------------------------------
STE11_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK22_Scer_STE11-Unclassified       -----------------------------------------------LSSHSSHKLSRSD
SSK2_Scer_STE11-Unclassified        -----------------------------------------------SSSSSSSRLRS--
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        --------------------------------------------VKFG------------
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    -----------------------------------------------NAE--------EQ
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       ------------------------------------------------------------
18758_Tthe_STE11-Unclassified       -----------------------------------------------SAK--------R-
23105_Tthe_STE11-Unclassified       -----------------------------------------------GN---------NK
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        -----------------------------------------------NAK--------QE
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    ------------------------------------------------------------
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  -----------------------------------------------SASSNLNRSVRSS
CC1G_10513_Ccin_STE11-Unclassified  -------------------HSKPPP-------TDPYDHHPPALRTDLGSSYVQDHNHRPS
AqueK224_Aque_ASK                   ------------------------------------------------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 ------------------------------------------------------------
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        -----------------------------------------------FSFSSLQK-NQ--
STE11-p2_d-1_Smoe_STE11-plant2      -----------------------------------------------------AS-G---
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  --------------------------------------------PKPERHAESLLDICHD
MAP3K7_Hsap_ASK                     ------------------------------------------------------------
MAP3K6_Hsap_ASK                     ------------------------------------------------------------
MAP3K5_Hsap_ASK                     ------------------------------------------------------------
MAP3K4_Hsap_MEKK4                   ------------------------------------------------------------
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   -----DAAGSG-----TGFQPVAVPP--PH------------------------------
MEKK15_Mmus_MEKK15                  --------------------------------------------PRPERHAESLLDICHE
MAP3K7_Mmus_ASK                     ------------------------------------------------------------
MAP3K6_Mmus_ASK                     ------------------------------------------------------------
MAP3K5_Mmus_ASK                     ------------------------------------------------------------
MAP3K4_Mmus_MEKK4                   ------------------------------------------------------------
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   -----DAAAGA-----SRFQPAAGPP--PP------------------------------
nsy-1_Cele_ASK                      ------------------------------------------------------------
B0414.7_Cele_MEKK4                  ------------------------------------------------------------
STE11_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK22_Scer_STE11-Unclassified       ----LKALGGSET------ISD-GPS----------------------------------
SSK2_Scer_STE11-Unclassified        -----ESLGRNSNTTQ-ARVAS-SPI--SPG-----------------------------
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        -HQP-------TS----------------------S------------------------
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    ----VAREEENGNGHHSTV-----TAETP-------------------------------
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       ------------------------------------------------------------
18758_Tthe_STE11-Unclassified       ------------------------------------------------------------
23105_Tthe_STE11-Unclassified       ----I-----SLIVNNHIQQFE-IKATLP-------------------------------
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        ----I-----N-------------------------------------------------
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    ----------------------------AS------------------------------
MEKK2_Spur_MEKK2                    ------------------FQGIILPV--DP------------------------------
MEKK4_Spur_MEKK4                    ------------------------------------------------------------
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               -SRP-------LPISS---HSRRPNP--PPE-A--SSSRYPQQAPAP--------DVFTS
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  -TGP-------TI---------SLDP--PPG---TT------------------------
CC1G_10524_Ccin_STE11-Unclassified  --VP--------------FRETVP-P--VPDLPGR-------------------------
CC1G_13687_Ccin_STE11-Unclassified  ----L--KGRQSS------HSK-VPT----------------------------------
CC1G_10513_Ccin_STE11-Unclassified  LSSP-------SSLSSHAADESTP-P--PPT-PGVS------------------------
AqueK224_Aque_ASK                   ------------------------------------------------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 ------------------------------------------------------------
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      --DRVNALGRNTS-----YN----------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      --DRVNALGRNTS-----YN----------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        -----NRAGRNPHQKE-----A-VPKTVPPG-----------------------------
STE11-p2_d-1_Smoe_STE11-plant2      -------HGSS------------------PG-----------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  TN----------S----------------------SP-----TD----------------
MAP3K7_Hsap_ASK                     ------------------------------------------------------------
MAP3K6_Hsap_ASK                     ------------------------------------------------------------
MAP3K5_Hsap_ASK                     ------------------------------------------------------------
MAP3K4_Hsap_MEKK4                   ------------------------------------------------------------
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   -------GAASR-GGAHLTESV-----AAPDSGASSPAAAEPGE----------------
MEKK15_Mmus_MEKK15                  AG----------S----------------------TP-----ME----------------
MAP3K7_Mmus_ASK                     ------------------------------------------------------------
MAP3K6_Mmus_ASK                     ------------------------------------------------------------
MAP3K5_Mmus_ASK                     ------------------------------------------------------------
MAP3K4_Mmus_MEKK4                   ------------------------------------------------------------
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   -------GAASR-CGSHSAELA-----AARDSGARSPAGA--------------------
nsy-1_Cele_ASK                      ------------------------------------------------------------
B0414.7_Cele_MEKK4                  ------------------------------------------------------------
STE11_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK22_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK2_Scer_STE11-Unclassified        -------------------------------------------LHSTQYFRSPNAVYSPG
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        -------VA-------------STK-----------------------------------
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    ------------------------------------------------------------
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       ------------------------------------------------------------
18758_Tthe_STE11-Unclassified       ------------------------------------------------------------
23105_Tthe_STE11-Unclassified       ------------------------------------------------------------
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        ------------------------------------------------------------
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    -------LADDR-GSDHVLAIAGGVEARVLRNHLLMPM----------------------
MEKK2_Spur_MEKK2                    -------AADSNQVIS---------------------------E----------------
MEKK4_Spur_MEKK4                    ------------------------------------------------------------
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               TSSTSETAS-------------RSFQRFFENSF---------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  -------FA-------------ESLKAWTDNHVARWLSDMKCGM----------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10513_Ccin_STE11-Unclassified  ------------------------------------------------------------
AqueK224_Aque_ASK                   ------------------------------------------------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 ------------------------------------------------------------
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  ---------------------------------------LMT------------------
MAP3K7_Hsap_ASK                     ------------------------------------------------------------
MAP3K6_Hsap_ASK                     ------------------------------------------------------------
MAP3K5_Hsap_ASK                     ------------------------------------------------------------
MAP3K4_Hsap_MEKK4                   ------------------------------------------------------------
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   ---------------------------------------K--------------------
MEKK15_Mmus_MEKK15                  ---------------------------------------M-T------------------
MAP3K7_Mmus_ASK                     ------------------------------------------------------------
MAP3K6_Mmus_ASK                     ------------------------------------------------------------
MAP3K5_Mmus_ASK                     ------------------------------------------------------------
MAP3K4_Mmus_MEKK4                   ------------------------------------------------------------
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   ------------------------------------------------------------
nsy-1_Cele_ASK                      ------------------------------------------------------------
B0414.7_Cele_MEKK4                  ------------------------------------------------------------
STE11_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK22_Scer_STE11-Unclassified       --------------------------------------Q----------------LTFKD
SSK2_Scer_STE11-Unclassified        ESPLNTVQLFNRLPGIPQGQFFHQNAISGSSSSSARSSR----------------RPSNI
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ------------------------------------------------------------
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    ------------------------------------------------------------
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       ------------------------------------------------------------
18758_Tthe_STE11-Unclassified       ------------------------------------------------------------
23105_Tthe_STE11-Unclassified       ------------------------------------------------------------
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        ------------------------------------------------------------
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ---------------------------------------I--------------------
MEKK4_Spur_MEKK4                    ------------------------------------------------------------
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ---------------------------------------H--------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  --------------------------------------N---------------------
CC1G_10513_Ccin_STE11-Unclassified  ------------------------------------------------------------
AqueK224_Aque_ASK                   ------------------------------------------------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 ------------------------------------------------------------
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        --------------------------------------NKT-SSVSPLRARAAAAK----
STE11-p2_d-1_Smoe_STE11-plant2      --------------------------------------SGHNSTVD--------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  -----VTKNQN-------------------------------------------------
MAP3K7_Hsap_ASK                     ------------------------------------------------------------
MAP3K6_Hsap_ASK                     ------------------------------------------------------------
MAP3K5_Hsap_ASK                     ------------------------------------------------------------
MAP3K4_Hsap_MEKK4                   ------------------------------------------------------------
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   ------------------------------------------------------------
MEKK15_Mmus_MEKK15                  -----VSQTEN-------------------------------------------------
MAP3K7_Mmus_ASK                     ------------------------------------------------------------
MAP3K6_Mmus_ASK                     ------------------------------------------------------------
MAP3K5_Mmus_ASK                     ------------------------------------------------------------
MAP3K4_Mmus_MEKK4                   ------------------------------------------------------------
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   ------------------------------------------------------------
nsy-1_Cele_ASK                      ------------------------------------------------------------
B0414.7_Cele_MEKK4                  ------------------------------------------------------------
STE11_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK22_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK2_Scer_STE11-Unclassified        GLP---------LPKNPQQSLPKLST----------------------------------
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ------------------------------------------------------------
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    --PTP------PIPP----------IPPIRLRREQSVEEDVARVE---------------
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       ----------NM------------------------------------------------
18758_Tthe_STE11-Unclassified       -----K----NF-LF----------TR---------------------------------
23105_Tthe_STE11-Unclassified       --FSNR----SN--F----------KPPL------------YRGNAHLLVANGKKNHSLS
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        --NKSD----NI--F----------SPSL-NSQNIQSSKKIYQHQ---------------
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    ------------------------------------------------------------
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10513_Ccin_STE11-Unclassified  ------------------------------------------------------------
AqueK224_Aque_ASK                   ------------------------------------------------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 ------------------------------------------------------------
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  ------------------------------------------------------------
MAP3K7_Hsap_ASK                     ------------------------------------------------------------
MAP3K6_Hsap_ASK                     ------------------------------------------------------------
MAP3K5_Hsap_ASK                     ------------------------------------------------------------
MAP3K4_Hsap_MEKK4                   ------------------------------------------------------------
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   ------------------------------------------------------------
MEKK15_Mmus_MEKK15                  ------------------------------------------------------------
MAP3K7_Mmus_ASK                     ------------------------------------------------------------
MAP3K6_Mmus_ASK                     ------------------------------------------------------------
MAP3K5_Mmus_ASK                     ------------------------------------------------------------
MAP3K4_Mmus_MEKK4                   ------------------------------------------------------------
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   ------------------------------------------------------------
nsy-1_Cele_ASK                      ------------------------------------------------------------
B0414.7_Cele_MEKK4                  ------------------------------------------------------------
STE11_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK22_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK2_Scer_STE11-Unclassified        ---------------------QPVPVHKKVEASKTESEIIKKPAPVNSNQDPLLTTPTLV
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ------------------------------------------------------------
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    -------------YRVKQTPSRPV--------------------QMTRNRIGALEEDLPP
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------N-------NRQ-
15684_Tthe_STE11-Unclassified       ------------------------------------------------------------
18758_Tthe_STE11-Unclassified       -----------------E---IP-------------------------------------
23105_Tthe_STE11-Unclassified       IHHPHHFHLNNNGNHLKV---IP-------------------------------------
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        -----------------L---QPL--------------------QLVQK-------DDQK
7147_Tthe_STE11-Unclassified        ------------------------------------------------N-------AIQ-
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    ------------------------------------------------------------
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  ---------------------------------------------VNTKQDIYS------
CC1G_10513_Ccin_STE11-Unclassified  ------------------------------------------------------------
AqueK224_Aque_ASK                   ------------------------------------------------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 ------------------------------------------------------------
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  ------------------------------------------------------------
MAP3K7_Hsap_ASK                     ------------------------------------------------------------
MAP3K6_Hsap_ASK                     ------------------------------------------------------------
MAP3K5_Hsap_ASK                     ------------------------------------------------------------
MAP3K4_Hsap_MEKK4                   ------------------------------------------------------------
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   ------------------------------------------------------------
MEKK15_Mmus_MEKK15                  ------------------------------------------------------------
MAP3K7_Mmus_ASK                     ------------------------------------------------------------
MAP3K6_Mmus_ASK                     ------------------------------------------------------------
MAP3K5_Mmus_ASK                     ------------------------------------------------------------
MAP3K4_Mmus_MEKK4                   ------------------------------------------------------------
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   ------------------------------------------------------------
nsy-1_Cele_ASK                      ------------------------------------------------------------
B0414.7_Cele_MEKK4                  ------------------------------------------------------------
STE11_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK22_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK2_Scer_STE11-Unclassified        ISPELASLNTTNTSIMSTPQNIT-------------------------NQTSNKHIPTRS
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ------------------------------------------------------------
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    EDELAAHYEAFGTTPPRTRLKIKNRDWERKQKVVNVTASADLPASVGGT-----------
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       -----------------------------------------------IS-----------
18758_Tthe_STE11-Unclassified       FSE--------------------------------------------DT-----------
23105_Tthe_STE11-Unclassified       TTN--------------------------------------------KK-----------
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        EHK--------------------------------------------KK-----------
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    ------------------------------------------------------------
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10513_Ccin_STE11-Unclassified  ------------------------------------------------------------
AqueK224_Aque_ASK                   ------------------------------------------------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 ------------------------------------------------------------
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        -------------------------------------------------QGMHLHLPARS
STE11-p2_d-1_Smoe_STE11-plant2      -------------------------------------------------TGQTSWCQSRA
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  ----------------------IILQSISRS-----------------------------
MAP3K7_Hsap_ASK                     -------------------------YHLGV------------------------------
MAP3K6_Hsap_ASK                     -------------------------YHLGV------------------------------
MAP3K5_Hsap_ASK                     -------------------------YHLGV------------------------------
MAP3K4_Hsap_MEKK4                   -------------------------Q----------------------------------
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   ------------------------------------------------------------
MEKK15_Mmus_MEKK15                  ----------------------LTLQSISSS-----------------------------
MAP3K7_Mmus_ASK                     -------------------------YHLGV------------------------------
MAP3K6_Mmus_ASK                     -------------------------YHLGV------------------------------
MAP3K5_Mmus_ASK                     -------------------------YHLGV------------------------------
MAP3K4_Mmus_MEKK4                   -------------------------Q----------------------------------
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   ------------------------------------------------------------
nsy-1_Cele_ASK                      -------------------------YHIGV------------------------------
B0414.7_Cele_MEKK4                  -------------------------Y----------------------------------
STE11_Scer_STE11-Unclassified       -------------------------IALGVN-----------------------------
SSK22_Scer_STE11-Unclassified       ---------------------------------------RYVFNESLYLKK---LKKTAL
SSK2_Scer_STE11-Unclassified        QPNGSTSSSTLQDIVTTNSSQRSVGHHGGSTTSLRTYKKQYVLNEQLYLRK---MRNRAN
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ------------------------------------------------------------
Pk92B_Dmel_ASK                      -------------------------YHYGV------------------------------
Mekk1_Dmel_MEKK4                    -PKK------------------------------TRTARSRVLRRNTMDCALLNEMFVND
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       -PEQ--------------------------------------------------------
18758_Tthe_STE11-Unclassified       -PNQ--------------------------------------------------------
23105_Tthe_STE11-Unclassified       -PKN--------------------------------------------------------
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        -PQS--------------------------------------------------------
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    -------------------------ITQRIR-----------------------------
ASK_Spur_ASK                        -------------------------YHMGV------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  -----------------------------------QFVKRYRTKEHRYVDEMEDFRSDPD
CC1G_10513_Ccin_STE11-Unclassified  ------------------------------------------------------------
AqueK224_Aque_ASK                   -------------------------YHLGL------------------------------
AqueK225_Aque_MEKK1                 -------------------------THLSV------------------------------
AqueK226_Aque_MEKK15                -------------------------NDIGE------------------------------
AqueK227_Aque_MEKK2                 -------------------------FALSI------------------------------
AqueK228_Aque_MEKK4                 -------------------------SHM--RPSFS-------------------------
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        APTSLISSPSHSPRRLSSSEQQAL------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      SPE---LSPNPSPR----------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  ---------E------E-------------------------------------------
MAP3K7_Hsap_ASK                     ------------------------------------------------------------
MAP3K6_Hsap_ASK                     ------------------------------------------------------------
MAP3K5_Hsap_ASK                     ------------------------------------------------------------
MAP3K4_Hsap_MEKK4                   ------------------------------------------------------------
MAP3K3_Hsap_MEKK2                   -----------------------------------------MPGYETM----KNK--D--
MAP3K2_Hsap_MEKK2                   -----------------------------------------LSLQETR----KAK-----
MAP3K1_Hsap_MEKK1                   -----------------RAPAAEPSPAAAPAGREME-------------------NKE--
MEKK15_Mmus_MEKK15                  ---------E------D-------------------------------------------
MAP3K7_Mmus_ASK                     ------------------------------------------------------------
MAP3K6_Mmus_ASK                     ------------------------------------------------------------
MAP3K5_Mmus_ASK                     ------------------------------------------------------------
MAP3K4_Mmus_MEKK4                   ------------------------------------------------------------
MAP3K3_Mmus_MEKK2                   -----------------------------------------LSGYETM----KNK--D--
MAP3K2_Mmus_MEKK2                   -----------------------------------------LSLQETR----KAK-----
MAP3K1_Mmus_MEKK1                   ----------------------EPPSAAAPSGREME-------------------NKE--
nsy-1_Cele_ASK                      ------------------------------------------------------------
B0414.7_Cele_MEKK4                  ------------------------------------------------------------
STE11_Scer_STE11-Unclassified       ---------K------IG------------------------------DR-------LKI
SSK22_Scer_STE11-Unclassified       DDYYTRGIK-L-------------------------------------------------
SSK2_Scer_STE11-Unclassified        DDYYTRGIVAS-------------------------------------------------
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ------------------------------------------------------------
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    ESKRTDKRLQS-------------------------------------------------
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       ------------------------------------------------------------
18758_Tthe_STE11-Unclassified       ------------------------------------------------------------
23105_Tthe_STE11-Unclassified       ------------------------------------------------------------
29763_Tthe_STE11-Unclassified       -----------------G------------------------------DN-------D--
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        ------------------------------------------------------------
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    -----------------------------------EARSLNLSR----ELLLQSSSDK--
MEKK2_Spur_MEKK2                    -----------------TDNL------------------ISLRVQGNRN---RGR-----
MEKK4_Spur_MEKK4                    ------------------------------------------------------------
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  -----------------AEVFRINDIRGDVLLELDQDTLKEMNIVSIGDRIRILNAVK--
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  SHYYHKGLGQL-------------------------------------------------
CC1G_10513_Ccin_STE11-Unclassified  ------------------------------------------------------------
AqueK224_Aque_ASK                   ------------------------------------------------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ---------NALDVAPP-------------------------------------------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 ------------------------------------------------------------
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  ------------------F-------------------------------D---------
MAP3K7_Hsap_ASK                     ------------------------------------------------------------
MAP3K6_Hsap_ASK                     ------------------------------------------------------------
MAP3K5_Hsap_ASK                     ------------------------------------------------------------
MAP3K4_Hsap_MEKK4                   ------------------------------------------------------------
MAP3K3_Hsap_MEKK2                   ---------TGH--SNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVR-------
MAP3K2_Hsap_MEKK2                   ---------SSS--PKKQ-------------------------------NDVR-------
MAP3K1_Hsap_MEKK1                   --TLKGLHKMDD--RPEE-------------------------------RMIREKLKATC
MEKK15_Mmus_MEKK15                  ------------------F-------------------------------D---------
MAP3K7_Mmus_ASK                     ------------------------------------------------------------
MAP3K6_Mmus_ASK                     ------------------------------------------------------------
MAP3K5_Mmus_ASK                     ------------------------------------------------------------
MAP3K4_Mmus_MEKK4                   ------------------------------------------------------------
MAP3K3_Mmus_MEKK2                   ---------TGH--PNRQ-------------------------------SDVR-------
MAP3K2_Mmus_MEKK2                   ---------PSS--PKKQ-------------------------------NDVR-------
MAP3K1_Mmus_MEKK1                   --TLKGLHKMED--RPEE-------------------------------RMIREKLKATC
nsy-1_Cele_ASK                      ------------------------------------------------------------
B0414.7_Cele_MEKK4                  ------------------------------------------------------------
STE11_Scer_STE11-Unclassified       LRKSK------------SF-------------------------------QRD-------
SSK22_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK2_Scer_STE11-Unclassified        ------------------------------------------------------------
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        -------SSSKS--PR---------AT----------------SRKSIYDD----IRSQF
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    ------------------------------------------------------------
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ----------------------------------------------------R-------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       ------------------------------------------------------------
18758_Tthe_STE11-Unclassified       ------------------------------------------------------------
23105_Tthe_STE11-Unclassified       ------------------------------------------------------------
29763_Tthe_STE11-Unclassified       -QTQK------------EK-------------------------------QEK-------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        ------------------------------------------------------------
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    --EMKRMSKLDD--PLEK-------------------------------NAIREKLRGK-
MEKK2_Spur_MEKK2                    ---------GSS--SSHS-------------------------------TEIR-------
MEKK4_Spur_MEKK4                    ------------------------------------------------------------
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ---------------------------------------------RTATRS----KKVPT
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  --LLRQRAAARTPSPI---HVTRPTASHTRTGSENLSLEQGVASGR--------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10513_Ccin_STE11-Unclassified  -------------------------------------------------------LPLAS
AqueK224_Aque_ASK                   ------------------------------------------------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 ------------------------------------------------------------
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ----------RG--PEE-------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ---------STE--PG--------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ---------STE--PG--------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  ------------------------------------------------------------
MAP3K7_Hsap_ASK                     ------------------------------------------------------------
MAP3K6_Hsap_ASK                     ------------------------------------------------------------
MAP3K5_Hsap_ASK                     ------------------------------------------------------------
MAP3K4_Hsap_MEKK4                   ------------------------------------------------------------
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   MPAWKHEWLERRNRRGPV------------------------------------------
MEKK15_Mmus_MEKK15                  ------------------------------------------------------------
MAP3K7_Mmus_ASK                     ------------------------------------------------------------
MAP3K6_Mmus_ASK                     ------------------------------------------------------------
MAP3K5_Mmus_ASK                     ------------------------------------------------------------
MAP3K4_Mmus_MEKK4                   ------------------------------------------------------------
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   MPAWKHEWLERRNRRGPV------------------------------------------
nsy-1_Cele_ASK                      ------------------------------------------------------------
B0414.7_Cele_MEKK4                  ------------------------------------------------------------
STE11_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK22_Scer_STE11-Unclassified       ------------------------------------TNRYE-------------------
SSK2_Scer_STE11-Unclassified        ----------------------------------------S-------------------
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        PNLTPNSTSSQFYESTPVIEQSFNWTTDDHISAGTLENPTSFTNSSYKNDNGPSSLSDSR
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    ------------------------------------LLRDSEREMKNSLATTAVAAPRGN
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       ------------------------------------------------------------
18758_Tthe_STE11-Unclassified       ------------------------------------------------------------
23105_Tthe_STE11-Unclassified       ------------------------------------------------------------
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        ------------------------------------------------------------
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    ------------------------------------------------------------
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               P------PVDEF------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  ----------------------------------------V-------------------
CC1G_10513_Ccin_STE11-Unclassified  PPTIPAKPVHPLHEALP--------------------------------------INDRH
AqueK224_Aque_ASK                   ------------------------------------------------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 ------------------------------------------------------------
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  ------------------------------------------------------------
MAP3K7_Hsap_ASK                     ------------------------------------------------------------
MAP3K6_Hsap_ASK                     ------------------------------------------------------------
MAP3K5_Hsap_ASK                     ------------------------------------------------------------
MAP3K4_Hsap_MEKK4                   ------------------------------------------------------------
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   ------------------------------------------------------------
MEKK15_Mmus_MEKK15                  ------------------------------------------------------------
MAP3K7_Mmus_ASK                     ------------------------------------------------------------
MAP3K6_Mmus_ASK                     ------------------------------------------------------------
MAP3K5_Mmus_ASK                     ------------------------------------------------------------
MAP3K4_Mmus_MEKK4                   ------------------------------------------------------------
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   ------------------------------------------------------------
nsy-1_Cele_ASK                      ------------------------------------------------------------
B0414.7_Cele_MEKK4                  ------------------------------------------------------------
STE11_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK22_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK2_Scer_STE11-Unclassified        ------------------------------------------------------------
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        KSSGGNSV----------------------------------------------------
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    SFHETAHPLESLDQIMPLNSEAMAPIPLRIASKVVESCNRYRCVSSRPIGYRSSAPPLAF
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       ------------------------------------------------------------
18758_Tthe_STE11-Unclassified       ------------------------------------------------------------
23105_Tthe_STE11-Unclassified       ------------------------------------------------------------
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        ------------------------------------------------------------
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    ------------------------------------------------------------
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ----ATITAKAKK------------------GKEKE------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ----------GHSRKESTRPPPITIHPNANKGDLP------------------------D
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10513_Ccin_STE11-Unclassified  YPDVHQTSARGGT------------------VTN-MLTNLRNWRHGSTPRTPVEASAARR
AqueK224_Aque_ASK                   ------------------------------------------------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 ------------------------------------------------------------
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  ------------------------------------------------------------
MAP3K7_Hsap_ASK                     ------------------------------------------------------------
MAP3K6_Hsap_ASK                     ------------------------------------------------------------
MAP3K5_Hsap_ASK                     ------------------------------------------------------------
MAP3K4_Hsap_MEKK4                   ------------------------------------------------------------
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   -------------------VVKPIPVKGDGSEMNHLAAESPGEVQASAASPASKGRRSPS
MEKK15_Mmus_MEKK15                  ------------------------------------------------------------
MAP3K7_Mmus_ASK                     ------------------------------------------------------------
MAP3K6_Mmus_ASK                     ------------------------------------------------------------
MAP3K5_Mmus_ASK                     ------------------------------------------------------------
MAP3K4_Mmus_MEKK4                   ------------------------------------------------------------
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   -------------------VVKPIPIKGDGSEMNNLAAEPQGEGQAGSAAPAPKGRRSPS
nsy-1_Cele_ASK                      ------------------------------------------------------------
B0414.7_Cele_MEKK4                  ------------------------------------------------------------
STE11_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK22_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK2_Scer_STE11-Unclassified        ------------------------------------------------------------
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ------------------------------------------------------------
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    AAQLPAGM----------------------------------------------------
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       -------M----------------------------------------------------
18758_Tthe_STE11-Unclassified       -------M----------------------------------------------------
23105_Tthe_STE11-Unclassified       -------L----------------------------------------------------
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        -------I----------------------------------------------------
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    ----------------------------------------PGVRREGGDAPRTKGPMGSR
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    ------------------------------------------------------------
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  LIREPPPDSASGRSMMAPPPVR----------------------------------PLPV
CC1G_10524_Ccin_STE11-Unclassified  --------------------------------------------------------LLPQ
CC1G_13687_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10513_Ccin_STE11-Unclassified  P--------------------R----------------------------------TSPS
AqueK224_Aque_ASK                   ------------------------------------------------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 ------------------------------------------------------------
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  ------------------------------------------------------------
MAP3K7_Hsap_ASK                     ------------------------------------------------------------
MAP3K6_Hsap_ASK                     ------------------------------------------------------------
MAP3K5_Hsap_ASK                     ------------------------------------------------------------
MAP3K4_Hsap_MEKK4                   ------------------------------------------------------------
MAP3K3_Hsap_MEKK2                   ---------IKFEHNGERRIIAFSRP---------------------------VKYE---
MAP3K2_Hsap_MEKK2                   ---------VKFEHRGEKRILQFPRP---------------------------VKLE---
MAP3K1_Hsap_MEKK1                   PGNSPSGRTVKSESPGVRRKRVSPVPFQSGRITPPRR------------APSPD------
MEKK15_Mmus_MEKK15                  ------------------------------------------------------------
MAP3K7_Mmus_ASK                     ------------------------------------------------------------
MAP3K6_Mmus_ASK                     ------------------------------------------------------------
MAP3K5_Mmus_ASK                     ------------------------------------------------------------
MAP3K4_Mmus_MEKK4                   ------------------------------------------------------------
MAP3K3_Mmus_MEKK2                   ---------IKFEHNGERRIIAFSRP---------------------------VRYE---
MAP3K2_Mmus_MEKK2                   ---------VKFEHRGEKRILQVTRP---------------------------VKLE---
MAP3K1_Mmus_MEKK1                   PGSSPSGRSVKPESPGVRRKRVSPVPFQSGRITPPRR------------APSPD------
nsy-1_Cele_ASK                      ------------------------------------------------------------
B0414.7_Cele_MEKK4                  ------------------------------------------------------------
STE11_Scer_STE11-Unclassified       -----------------KRIEQVNRL---------------------------KNLM---
SSK22_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK2_Scer_STE11-Unclassified        --------------------------------------------------------NF-E
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ------------------------------------------------------------
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    --------------------------------------------------------L---
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ---------IKCILGDDIRIIKFNSN---------------------------ISYG---
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       --------------------------------------------------------Q---
18758_Tthe_STE11-Unclassified       --------------------------------------------------------N---
23105_Tthe_STE11-Unclassified       --------------------------------------------------------N---
29763_Tthe_STE11-Unclassified       ---------RKLERKKNQRN----------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        --------------------------------------------------------Q---
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    PGSPTGGH---------------------------RR------------VPSPN------
MEKK2_Spur_MEKK2                    ---------VKFEFNGEKRILQIPRP---------------------------LKYD---
MEKK4_Spur_MEKK4                    ------------------------------------------------------------
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  PQ----------------------------------NATPT-ASQ---------------
CC1G_10524_Ccin_STE11-Unclassified  PS----------------------------------S-SPH-------------------
CC1G_13687_Ccin_STE11-Unclassified  --------------------------------------------------------DV-G
CC1G_10513_Ccin_STE11-Unclassified  VS------------------------------------TPDSAVSSNSNLPN--------
AqueK224_Aque_ASK                   ------------------------------------------------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 ---------------------------------------------------------YTT
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ----------------------LFSP---------------------------NISE---
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  ------------------------------------------------------------
MAP3K7_Hsap_ASK                     ------------------------------------------------------------
MAP3K6_Hsap_ASK                     ------------------------------------------------------------
MAP3K5_Hsap_ASK                     ------------------------------------------------------------
MAP3K4_Hsap_MEKK4                   ------------------------------------------------------------
MAP3K3_Hsap_MEKK2                   -----------------DV-----------------------------------------
MAP3K2_Hsap_MEKK2                   -----------------DL-----------------------------------------
MAP3K1_Hsap_MEKK1                   ------------------------------------------------------------
MEKK15_Mmus_MEKK15                  ------------------------------------------------------------
MAP3K7_Mmus_ASK                     ------------------------------------------------------------
MAP3K6_Mmus_ASK                     ------------------------------------------------------------
MAP3K5_Mmus_ASK                     ------------------------------------------------------------
MAP3K4_Mmus_MEKK4                   ------------------------------------------------------------
MAP3K3_Mmus_MEKK2                   -----------------DV-----------------------------------------
MAP3K2_Mmus_MEKK2                   -----------------DL-----------------------------------------
MAP3K1_Mmus_MEKK1                   ------------------------------------------------------------
nsy-1_Cele_ASK                      ------------------------------------------------------------
B0414.7_Cele_MEKK4                  ---------------------------------------------STALSMAPQQNLSVE
STE11_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK22_Scer_STE11-Unclassified       ------EDDGDDEI-IRLS-----------------------------------------
SSK2_Scer_STE11-Unclassified        DDEENFSNKGEDDLELE-------------------------------------------
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ------------------------------------------------------------
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    -----------------RS-----------------------------------------
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   -----------------GL-----------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       ------------------------------------------------------------
18758_Tthe_STE11-Unclassified       -----------------KI-----------------------------------------
23105_Tthe_STE11-Unclassified       ------------------------------------------------------------
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        ------------------------------------------------------------
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    -----------------DI-----------------------------------------
MEKK4_Spur_MEKK4                    ------------------------------------------------------------
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  D------ASDDEDY-MS-------------------------------------------
CC1G_10513_Ccin_STE11-Unclassified  ------------------------------------------------------------
AqueK224_Aque_ASK                   ------------------------------------------------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 DNIIPYYS----------LSSLSHAPPGVSIERSQSDAQLSLTLSSS-------------
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      -----------------RA-----------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  --------------QDGDCS-----------------------------HSTLVNEEEDP
MAP3K7_Hsap_ASK                     ------------------------------------------------------------
MAP3K6_Hsap_ASK                     ------------------------------------------------------------
MAP3K5_Hsap_ASK                     ------------------------------------------------------------
MAP3K4_Hsap_MEKK4                   ------------------------------------------------------------
MAP3K3_Hsap_MEKK2                   ---------EHKVTTVFGQP-----------------------------LDL--------
MAP3K2_Hsap_MEKK2                   ---------RSKAKIAFGQS-----------------------------MDL--------
MAP3K1_Hsap_MEKK1                   ------------------------------------------------------------
MEKK15_Mmus_MEKK15                  --------------LEDDFS-----------------------------PFILAREGAAP
MAP3K7_Mmus_ASK                     ------------------------------------------------------------
MAP3K6_Mmus_ASK                     ------------------------------------------------------------
MAP3K5_Mmus_ASK                     ------------------------------------------------------------
MAP3K4_Mmus_MEKK4                   ------------------------------------------------------------
MAP3K3_Mmus_MEKK2                   ---------EHKVTTVFGQP-----------------------------LDL--------
MAP3K2_Mmus_MEKK2                   ---------RSKSKIAFGQS-----------------------------MDL--------
MAP3K1_Mmus_MEKK1                   ------------------------------------------------------------
nsy-1_Cele_ASK                      ------------------------------------------------------------
B0414.7_Cele_MEKK4                  SLSDALDELE--------------------------------------------------
STE11_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK22_Scer_STE11-Unclassified       ---------N--------------------------------------------------
SSK2_Scer_STE11-Unclassified        ------------------------------------------------------------
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ------------------------------------------------------------
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    ---------DG-------------------------------------------------
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ---------MNQLEQDFQCP-----------------------------ISI--------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       ------------------------------------------------------------
18758_Tthe_STE11-Unclassified       ---------EG-------------------------------------------------
23105_Tthe_STE11-Unclassified       ----------S-------------------------------------------------
29763_Tthe_STE11-Unclassified       -------------KSDFG------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        ------------------------------------------------------------
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ---------LLKARTTFGQP-----------------------------VDM--------
MEKK4_Spur_MEKK4                    ------------------------------------------------------------
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               -------------------------------------------------REI--------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10513_Ccin_STE11-Unclassified  ------------------PDKILICVTTEADPERLNIVDVSGAKDATSIRES--------
AqueK224_Aque_ASK                   ------------------------------------------------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 ---SSHSMHC--------------------------------------------------
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ---------H--------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------DE-----------------------------KDL--------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------DE-----------------------------KDL--------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  SGGRQDWQPRT---EGVEITVTFPRDVSPPQEMSQEDLKEKNLINSSLQEWAQAHAVSHP
MAP3K7_Hsap_ASK                     ------------------------------------------------------------
MAP3K6_Hsap_ASK                     ------------------------------------------------------------
MAP3K5_Hsap_ASK                     ------------------------------------------------------------
MAP3K4_Hsap_MEKK4                   ------------------------------------------------------------
MAP3K3_Hsap_MEKK2                   ----------------HY------M-----------------------------------
MAP3K2_Hsap_MEKK2                   ----------------HY------T-----------------------------------
MAP3K1_Hsap_MEKK1                   ------------------------------------------------------------
MEKK15_Mmus_MEKK15                  RG-E-NWPRRTEGVEIIV-----TFPPDPLQEASQEDLKESNQVTSEHQEREQVHPVSPP
MAP3K7_Mmus_ASK                     ------------------------------------------------------------
MAP3K6_Mmus_ASK                     ------------------------------------------------------------
MAP3K5_Mmus_ASK                     ------------------------------------------------------------
MAP3K4_Mmus_MEKK4                   ------------------------------------------------------------
MAP3K3_Mmus_MEKK2                   ----------------HY------M-----------------------------------
MAP3K2_Mmus_MEKK2                   ----------------HY------T-----------------------------------
MAP3K1_Mmus_MEKK1                   ------------------------------------------------------------
nsy-1_Cele_ASK                      ------------------------------------------------------------
B0414.7_Cele_MEKK4                  ------------------------------------------------------------
STE11_Scer_STE11-Unclassified       ------------------------------E-----------------------------
SSK22_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK2_Scer_STE11-Unclassified        ------------------------------------------------------------
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ------------------------------------------------------------
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    ------------------------------------------------------------
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ----------------H------QYEDYEGD-----------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       ------------------------------------------------------------
18758_Tthe_STE11-Unclassified       ------------------------------------------------------------
23105_Tthe_STE11-Unclassified       ------------------------------------------------------------
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        ------------------------------------------------------------
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ----------------FL------T-----------------------------------
MEKK4_Spur_MEKK4                    ------------------------------------------------------------
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ----------------HK------S-----------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10513_Ccin_STE11-Unclassified  ----------------IL------S-----------------------------------
AqueK224_Aque_ASK                   ------------------------------------------------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 ------------------------------------------------------------
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ----------------FR------L-----------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ----------------FR------L-----------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  NEIETVELRKKKLTMRPLVLQKEESSRELCNVNLGFLLPRSCLELNISKSVTREDAPHFL
MAP3K7_Hsap_ASK                     ------------------------------------------------------------
MAP3K6_Hsap_ASK                     ------------------------------------------------------------
MAP3K5_Hsap_ASK                     ------------------------------------------------------------
MAP3K4_Hsap_MEKK4                   ------------------------------------------------------------
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   ------------------------------------------------------------
MEKK15_Mmus_MEKK15                  DDAEMVGLTGRMLTTQPSLLKTDGSSEELCGVDVALSPPRPCLDSSLAASAAGEVAPCVL
MAP3K7_Mmus_ASK                     ------------------------------------------------------------
MAP3K6_Mmus_ASK                     ------------------------------------------------------------
MAP3K5_Mmus_ASK                     ------------------------------------------------------------
MAP3K4_Mmus_MEKK4                   ------------------------------------------------------------
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   ------------------------------------------------------------
nsy-1_Cele_ASK                      ------------------------------------------------------------
B0414.7_Cele_MEKK4                  ------------------------------------------------------------
STE11_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK22_Scer_STE11-Unclassified       --------------------------------------------------GDRIDEDLHS
SSK2_Scer_STE11-Unclassified        ------------------------------------------------------------
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ------------------------------------------------------------
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    ------------------------------------------------------------
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       ------------------------------------------------------------
18758_Tthe_STE11-Unclassified       ------------------------------------------------------------
23105_Tthe_STE11-Unclassified       -----------------------------------NNNNSINNISINHSNSNS-------
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        -------------------------------------------------SSDRILSKDYS
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    ------------------------------------------------------------
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10513_Ccin_STE11-Unclassified  ------------------------------------------------------------
AqueK224_Aque_ASK                   ------------------------------------------------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 ------------------------------------------------------------
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  KEQQRKSEEFSTSHMKYSGRSIKFLLPPLSLLPTRSGVLTIPQNHKFPKEKERNIPSLTS
MAP3K7_Hsap_ASK                     ------------------------------------------------------------
MAP3K6_Hsap_ASK                     ------------------------------------------------------------
MAP3K5_Hsap_ASK                     ------------------------------------------------------------
MAP3K4_Hsap_MEKK4                   ------------------------------------------------------------
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   ------------------------------------------------------------
MEKK15_Mmus_MEKK15                  KEQQRQSDEFPTSDISYSSRRTGLPLPPLSCLPMRSCIFNMEKSPKSPRHRERKVPSLSL
MAP3K7_Mmus_ASK                     ------------------------------------------------------------
MAP3K6_Mmus_ASK                     ------------------------------------------------------------
MAP3K5_Mmus_ASK                     ------------------------------------------------------------
MAP3K4_Mmus_MEKK4                   ------------------------------------------------------------
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   ------------------------------------------------------------
nsy-1_Cele_ASK                      ------------------------------------------------------------
B0414.7_Cele_MEKK4                  ------------------------------------------------------------
STE11_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK22_Scer_STE11-Unclassified       GVK---------------------------------------------------------
SSK2_Scer_STE11-Unclassified        ------------------------------------------------------------
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ------------------------------------------------------------
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    ------------------------------------------------------------
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       ------------------------------------------------------------
18758_Tthe_STE11-Unclassified       ------------------------------------------------------------
23105_Tthe_STE11-Unclassified       -------------------IN---------------------------------------
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        KGKIFQIQKDEMSGFAINNFN---------------------------------------
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    ------------------------------------------------------------
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10513_Ccin_STE11-Unclassified  ------------------------------------------------------------
AqueK224_Aque_ASK                   ------------------------------------------------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 ------------------------------------------------------------
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  FVPKLSVSVRQS-------------DELSPSNEPPGALVKSLMDPTLRSSDGFIWSRNMC
MAP3K7_Hsap_ASK                     ------------------------------------------------------------
MAP3K6_Hsap_ASK                     ------------------------------------------------------------
MAP3K5_Hsap_ASK                     ------------------------------------------------------------
MAP3K4_Hsap_MEKK4                   ------------------------------------------------------------
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   ------------------------------------------------------------
MEKK15_Mmus_MEKK15                  SV---------PKLLEPLSRPLSQSAEFSSSKNHQEVTQEGPVEHTLRGSNCTLWSRNMC
MAP3K7_Mmus_ASK                     ------------------------------------------------------------
MAP3K6_Mmus_ASK                     ------------------------------------------------------------
MAP3K5_Mmus_ASK                     ------------------------------------------------------------
MAP3K4_Mmus_MEKK4                   ------------------------------------------------------------
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   ------------------------------------------------------------
nsy-1_Cele_ASK                      ------------------------------------------------------------
B0414.7_Cele_MEKK4                  ------------------------------------------------------------
STE11_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK22_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK2_Scer_STE11-Unclassified        ------------------------------------------------------------
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ------------------------------------------------------------
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    ------------------------------------------------------------
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       ------------------------------------------------------------
18758_Tthe_STE11-Unclassified       ------------------------------------------------------------
23105_Tthe_STE11-Unclassified       ------------------------------------------------------------
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        ------------------------------------------------------------
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    ------------------------------------------------------------
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10513_Ccin_STE11-Unclassified  ------------------------------------------------------------
AqueK224_Aque_ASK                   ------------------------------------------------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 ------------------------------------------------------------
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  SFPKT-----------------------------NHHRQCLEKEENWKSKEIEECNKIEI
MAP3K7_Hsap_ASK                     ------------------------------------------------------------
MAP3K6_Hsap_ASK                     ------------------------------------------------------------
MAP3K5_Hsap_ASK                     ------------------------------------------------------------
MAP3K4_Hsap_MEKK4                   ------------------------------------------------------------
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   ------------------------------------------------------------
MEKK15_Mmus_MEKK15                  SFRKSGKQGVAESWPSQEMEGWDKTKTSGFKEGPS-------------------------
MAP3K7_Mmus_ASK                     ------------------------------------------------------------
MAP3K6_Mmus_ASK                     ------------------------------------------------------------
MAP3K5_Mmus_ASK                     ------------------------------------------------------------
MAP3K4_Mmus_MEKK4                   ------------------------------------------------------------
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   ------------------------------------------------------------
nsy-1_Cele_ASK                      ------------------------------------------------------------
B0414.7_Cele_MEKK4                  ------------------------------------------------------------
STE11_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK22_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK2_Scer_STE11-Unclassified        ------------------------------------------------------------
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ------------------------------------------------------------
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    ------------------------------------------------------------
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       ------------------------------------------------------------
18758_Tthe_STE11-Unclassified       ------------------------------------------------------------
23105_Tthe_STE11-Unclassified       ------------------------------------------------------LQSNIP
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        ------------------------------------------------------NNNKLS
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    ------------------------------------------------------------
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10513_Ccin_STE11-Unclassified  ------------------------------------------------------------
AqueK224_Aque_ASK                   ------------------------------------------------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 ------------------------------------------------------------
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  THFEKGQSLVSFENLKEGNIPAVREEDIDCHGSKTRKP----------------------
MAP3K7_Hsap_ASK                     ------------------------------------------------------------
MAP3K6_Hsap_ASK                     ------------------------------------------------------------
MAP3K5_Hsap_ASK                     ------------------------------------------------------------
MAP3K4_Hsap_MEKK4                   ------------------------------------------------------------
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   ------------------------------------------------------------
MEKK15_Mmus_MEKK15                  --------LFSCESVKE-------------------------------------------
MAP3K7_Mmus_ASK                     ------------------------------------------------------------
MAP3K6_Mmus_ASK                     ------------------------------------------------------------
MAP3K5_Mmus_ASK                     ------------------------------------------------------------
MAP3K4_Mmus_MEKK4                   ------------------------------------------------------------
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   ------------------------------------------------------------
nsy-1_Cele_ASK                      ------------------------------------------------------------
B0414.7_Cele_MEKK4                  ------------------------------------------------------------
STE11_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK22_Scer_STE11-Unclassified       FFSTTPYCRKMRSDSDE-------------------------------------------
SSK2_Scer_STE11-Unclassified        --------------MDDLLKVEGEDKDNDFNFGYNFITSSTKNN----ENVVSMSLNYLK
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ------------------------------------------------------------
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    ------------------------------------------------------------
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       ------------------------------------------------------------
18758_Tthe_STE11-Unclassified       ------------------------------------------------------------
23105_Tthe_STE11-Unclassified       N----------------------------------SFHRPQSPVVLNI------------
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        A----------------------------------FQSYPQSPT---YKDQFNCKLQSKQ
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    ------------------------------------------------------------
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  -----------------LIGGNDGII----EGSMDEMAHPV-------------------
CC1G_10513_Ccin_STE11-Unclassified  ------------------------------------------------------------
AqueK224_Aque_ASK                   ------------------------------------------------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 ------------------------------------------------------------
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  -------------------------------------------EEE--------------
MAP3K7_Hsap_ASK                     ------------------------------------------------------------
MAP3K6_Hsap_ASK                     ------------------------------------------------------------
MAP3K5_Hsap_ASK                     ------------------------------------------------------------
MAP3K4_Hsap_MEKK4                   ------------------------------------------------------------
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   ------------------------------------------------------------
MEKK15_Mmus_MEKK15                  ---------------------------------------------DTTPTERERDSGYHV
MAP3K7_Mmus_ASK                     ------------------------------------------------------------
MAP3K6_Mmus_ASK                     ------------------------------------------------------------
MAP3K5_Mmus_ASK                     ------------------------------------------------------------
MAP3K4_Mmus_MEKK4                   ------------------------------------------------------------
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   ------------------------------------------------------------
nsy-1_Cele_ASK                      ------------------------------------------------------------
B0414.7_Cele_MEKK4                  ----------------------------------------GADR----------SKL---
STE11_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK22_Scer_STE11-Unclassified       ----------------------------------LAWNEIATER----------FKWQS-
SSK2_Scer_STE11-Unclassified        GKLDWLRDVNNDQPCEIEDEEWHSILGSEDLLSKLLQNPMVNNR----------FEWQT-
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ------------------------------------------------------------
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    -----------------------------------RATPGLGKR----------KDFHE-
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ----------------------------------KK-Q-------------------K-Q
15684_Tthe_STE11-Unclassified       ----------------------------------NK-E-----S----------SNLT-Q
18758_Tthe_STE11-Unclassified       -----------------------------------K-KTIFNRK----------TTIQ-Q
23105_Tthe_STE11-Unclassified       ------------------------SSDRHNLYQQQQ-Q-----Q----------YSFQHQ
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        SEETPTQKSQNQPLYRLPNNEANPFKDGNQLQI---------------------------
7147_Tthe_STE11-Unclassified        ----------------------------------QF-Q-----Q----------FRLE-Q
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    ------------------------------------------------------------
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  -------------------------------------TEKDQRR----------LEWQS-
CC1G_10513_Ccin_STE11-Unclassified  ------------------------------------------------------------
AqueK224_Aque_ASK                   ------------------------------------------------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 ----------------------------------------PPDR----------KQF---
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  --------NSQYLSSRKNESSVAKNYEQDPEIVCTIPSKFQETQHSE------ITPSQ--
MAP3K7_Hsap_ASK                     ------------------------------------------------------------
MAP3K6_Hsap_ASK                     ------------------------------------------------------------
MAP3K5_Hsap_ASK                     ------------------------------------------------------------
MAP3K4_Hsap_MEKK4                   ------------------------------------------------------------
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   ------------------------------------------------------------
MEKK15_Mmus_MEKK15                  SEMQRGGEDSQYLSSRKKESWTA-------------------------------------
MAP3K7_Mmus_ASK                     ------------------------------------------------------------
MAP3K6_Mmus_ASK                     ------------------------------------------------------------
MAP3K5_Mmus_ASK                     ------------------------------------------------------------
MAP3K4_Mmus_MEKK4                   ------------------------------------------------------------
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   ------------------------------------------------------------
nsy-1_Cele_ASK                      ------------------------------------------------------------
B0414.7_Cele_MEKK4                  ----------------------------------------------HMEITQFLK-----
STE11_Scer_STE11-Unclassified       ------------KVSSLSTATLSMNSELIPEKHCV---I---FILND------GSAKKVN
SSK22_Scer_STE11-Unclassified       -----MLA-------------------------------------RV------LKGDIVK
SSK2_Scer_STE11-Unclassified        -----MLS-------------------------------------KV------LKGDIVR
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ------------------------------------------------------------
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    -----TFA-------------------------------------NL------IKLGSVD
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------KVT-VKSKDDIME-----------------------------------
11359_Tthe_STE11-Unclassified       -----R-QN-------------------------------------N-------------
15684_Tthe_STE11-Unclassified       -----KLDN-------------------------------------N-------------
18758_Tthe_STE11-Unclassified       -----K-QN-------------------------------------Q-------------
23105_Tthe_STE11-Unclassified       -----A-HNQIHNNSNNNNNNNNNNTNNNCNNVGLGGNFGQLGFMR--------------
29763_Tthe_STE11-Unclassified       --------------S-VHAEDIIEK-----------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        --------------------------------------------QND-------------
7147_Tthe_STE11-Unclassified        -----K-EN-------------------------------------Q-------------
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    ------------------------------------------------------------
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  -----LLS-------------------------------------SV------LSGEVLK
CC1G_10513_Ccin_STE11-Unclassified  ------------------------------------------------------------
AqueK224_Aque_ASK                   ------------------------------------------------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                --------------------------------------HIRDILLSQ------LSKERPS
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 ----------------------------------------------YRNFSKRLKMIAKR
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  -----------------------------------------------------DEEMRN-
MAP3K7_Hsap_ASK                     ------------------------------------------------------------
MAP3K6_Hsap_ASK                     ------------------------------------------------------------
MAP3K5_Hsap_ASK                     ------------------------------------------------------------
MAP3K4_Hsap_MEKK4                   --------------RGQE-------NTS--------------------GFWLNRSNELIW
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   ------------------------------------------------------------
MEKK15_Mmus_MEKK15                  ------------------------------------------------------------
MAP3K7_Mmus_ASK                     ------------------------------------------------------------
MAP3K6_Mmus_ASK                     ------------------------------------------------------------
MAP3K5_Mmus_ASK                     ------------------------------------------------------------
MAP3K4_Mmus_MEKK4                   --------------RGQE-------NTA--------------------AFWFNRSNELIW
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   ------------------------------------------------------------
nsy-1_Cele_ASK                      ------------------------------------------------------------
B0414.7_Cele_MEKK4                  ---------------KADGEKSKQIQMSQRLMNCPQFGQTMRLIVEESEHTRYTFENILW
STE11_Scer_STE11-Unclassified       VNGCFN--------AD--------------------------------------------
SSK22_Scer_STE11-Unclassified       GEKTRI--------ANQVK---------------------------KPG-LNKELSDEIW
SSK2_Scer_STE11-Unclassified        NEKTKI--------ANQGK---------------------------GPG-FNTQFSDDIW
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ------------------------------------------------------------
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    RQDAKL--------S---Q---------------------------EEHTWQTELKDLIW
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------I---------------------------NQ------QNKLGE
15684_Tthe_STE11-Unclassified       ------------------I---------------------------QD------------
18758_Tthe_STE11-Unclassified       ------------------L---------------------------QQ------QQVQQQ
23105_Tthe_STE11-Unclassified       ------------------------------------------------DRPQRK------
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        ------------------N---------------------------IKAIKLESDQKSIS
7147_Tthe_STE11-Unclassified        ------------------V---------------------------QK----NKKNKQSE
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    --------------RQDG-------MTQ--------------------DVFQMQWNEILW
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  SEKTRL--------AVALD---------------------------SFGDEQNNFNMNIW
CC1G_10513_Ccin_STE11-Unclassified  ------------------------------------------------------------
AqueK224_Aque_ASK                   ------------------------------------------------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                TANRLL--------QAAWL---------------------------GDSVTVKK------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 QQQSSTQPGHIPRQHSEDL---------------------------NAKNPFGPDNEQLR
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  ------------------------------------------------------------
MAP3K7_Hsap_ASK                     ---------------------------------RE-------------------------
MAP3K6_Hsap_ASK                     ---------------------------------RE-------------------------
MAP3K5_Hsap_ASK                     ---------------------------------RE-------------------------
MAP3K4_Hsap_MEKK4                   LELQAWHAGRTIN-----------DQDFFLYTARQAI-PDIINEILTFKVDYGSF-----
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   ------------------------------------------------------------
MEKK15_Mmus_MEKK15                  ------------------------------------------------------------
MAP3K7_Mmus_ASK                     ---------------------------------RE-------------------------
MAP3K6_Mmus_ASK                     ---------------------------------RE-------------------------
MAP3K5_Mmus_ASK                     ---------------------------------RE-------------------------
MAP3K4_Mmus_MEKK4                   LELQAWHAGRTIN-----------DQDLFLYTARQAI-PDIINEILTFKVNYGSI-----
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   ------------------------------------------------------------
nsy-1_Cele_ASK                      ---------------------------------RE-------------------------
B0414.7_Cele_MEKK4                  LILKSYFSTTSTGRDVMIGKSEWIAEDEKIVKARKQY-MMVMDMIKEFKFEVGKN-----
STE11_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK22_Scer_STE11-Unclassified       LELKAWLNGRTMQ-----------EMEQSLTYLRDS-SDSVFEEIMKFQIPQ--------
SSK2_Scer_STE11-Unclassified        IELKAWMNGRTVE-----------DQNKSLRIFRDS-TDSVFQEIMAFKLED--------
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ------------------------------------------------------------
Pk92B_Dmel_ASK                      ---------------------------------RE-------------------------
Mekk1_Dmel_MEKK4                    LELQAWQADRTVE-----------QQDKYLFEARQG-VSDLLTHIINYKFQP--------
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       --------------------------------E--L-NNSKKDE-K--------------
15684_Tthe_STE11-Unclassified       -MNTPQQ-----------------------------------------------------
18758_Tthe_STE11-Unclassified       --------------------------------T--I-QNSNQ--GASLSVLQ--------
23105_Tthe_STE11-Unclassified       NRHNSIKLIKQKA-----------EHSVSSKQISSI-NILQSHNPN--------------
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        QLQSPRVRIKTIQ-----------KNMKSPTYQNLN-KEKLSQN-D--------------
7147_Tthe_STE11-Unclassified        --------------------------------DVVI-QDLDAQE-D--------------
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    LELTAYHNELSIT-----------DQDLHLINARKKV-AEVFDEIMKFKYQSGRS-----
ASK_Spur_ASK                        ---------------------------------RE-------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  LGIRAKFHGRSIE-----------EEKRKLDEKRIRIVDGVIDEIMNFRVVQ--------
CC1G_10513_Ccin_STE11-Unclassified  ------------------------------------------------------------
AqueK224_Aque_ASK                   ---------------------------------RE-------------------------
AqueK225_Aque_MEKK1                 ---------------------------------CP-------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 ---------------------------------YE-------------------------
AqueK228_Aque_MEKK4                 MELRAYLNNHTLE-----------DQEEADYQLQCES-GSILYRIIHYSFSSDSTLSGYF
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  ------------------------------------------------------------
MAP3K7_Hsap_ASK                     ------------------------------------------------------------
MAP3K6_Hsap_ASK                     ------------------------------------------------------------
MAP3K5_Hsap_ASK                     ------------------------------------------------------------
MAP3K4_Hsap_MEKK4                   ------------------------------------------------------------
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   ------------------------------------------------------------
MEKK15_Mmus_MEKK15                  ------------------------------------------------------------
MAP3K7_Mmus_ASK                     ------------------------------------------------------------
MAP3K6_Mmus_ASK                     ------------------------------------------------------------
MAP3K5_Mmus_ASK                     ------------------------------------------------------------
MAP3K4_Mmus_MEKK4                   ------------------------------------------------------------
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   ------------------------------------------------------------
nsy-1_Cele_ASK                      ------------------------------------------------------------
B0414.7_Cele_MEKK4                  -----------------------------------------------DKDDSPFES----
STE11_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK22_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK2_Scer_STE11-Unclassified        ------------------------------------------------------------
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ------------------------------------------------------------
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    ------------------------------------------------------------
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       ------------------------------------------------------------
18758_Tthe_STE11-Unclassified       ------------------------------------------------------------
23105_Tthe_STE11-Unclassified       ------------------------------------------------------------
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        ------------------------------------------------------------
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    ------------------------------------------------------------
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10513_Ccin_STE11-Unclassified  ------------------------------------------------------------
AqueK224_Aque_ASK                   ------------------------------------------------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 RGLSESAKSLPAQLNELKRGSLRRRKMMPLQENKEEEEEVEEKGEEEEGDETPLTSINNP
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  ------------------------------------------------------------
MAP3K7_Hsap_ASK                     ------------------------------------------------------------
MAP3K6_Hsap_ASK                     ------------------------------------------------------------
MAP3K5_Hsap_ASK                     ------------------------------------------------------------
MAP3K4_Hsap_MEKK4                   ------------------------------------------------------------
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   ------------------------------------------------------------
MEKK15_Mmus_MEKK15                  ------------------------------------------------------------
MAP3K7_Mmus_ASK                     ------------------------------------------------------------
MAP3K6_Mmus_ASK                     ------------------------------------------------------------
MAP3K5_Mmus_ASK                     ------------------------------------------------------------
MAP3K4_Mmus_MEKK4                   ------------------------------------------------------------
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   ------------------------------------------------------------
nsy-1_Cele_ASK                      ------------------------------------------------------------
B0414.7_Cele_MEKK4                  --------------------LNRR------------MEFSPD--YC--------------
STE11_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK22_Scer_STE11-Unclassified       ---------------------------------------------G--------------
SSK2_Scer_STE11-Unclassified        ---------------------------------------------N--------------
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ------------------------------------------------------------
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    ---------------------------------------------RYRREPSLISLDSGT
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       ------------------------------------------------------------
18758_Tthe_STE11-Unclassified       ---------------------------------------------SGQALPKLKIQ----
23105_Tthe_STE11-Unclassified       ------------------------------------------------------------
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        ------------------------------------------------------------
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    ------------------------------------------------------------
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  ---------------------------------------------D--------------
CC1G_10513_Ccin_STE11-Unclassified  ------------------------------------------------------------
AqueK224_Aque_ASK                   ------------------------------------------------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 SVRWEDGGGETEGEDEYGPQT--LIQQESNDSDALSVEFSFDNFLS--------------
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  ----------------------NKAAS---------------------------------
MAP3K7_Hsap_ASK                     ------------------------------------------------------------
MAP3K6_Hsap_ASK                     ------------------------------------------------------------
MAP3K5_Hsap_ASK                     ------------------------------------------------------------
MAP3K4_Hsap_MEKK4                   ------------------------------------------------------------
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   ------------------------------------------------------------
MEKK15_Mmus_MEKK15                  --------------------------RVVER-----DSGVEHPILCKLLEVSNSEMTPAE
MAP3K7_Mmus_ASK                     ------------------------------------------------------------
MAP3K6_Mmus_ASK                     ------------------------------------------------------------
MAP3K5_Mmus_ASK                     ------------------------------------------------------------
MAP3K4_Mmus_MEKK4                   ------------------------------------------------------------
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   ------------------------------------------------------------
nsy-1_Cele_ASK                      ------------------------------------------------------------
B0414.7_Cele_MEKK4                  ------------------------------------------------------------
STE11_Scer_STE11-Unclassified       ----------------------SIKKRLIRRLPH-E------------------------
SSK22_Scer_STE11-Unclassified       ---------------------------K-------------------------------I
SSK2_Scer_STE11-Unclassified        ---------------------------M--------------------------------
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ------------------------------------------------------------
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    HSDSNSNASSPLPSKMCQGCMSLYCKDC-------------------------------M
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------AHKI--------------------------------
15684_Tthe_STE11-Unclassified       ------------------------NLSI--------------------------------
18758_Tthe_STE11-Unclassified       -NDSVNNAANQNLGESSTAEKAVEEQER-------------------------------K
23105_Tthe_STE11-Unclassified       ------------------------YQKH-------------------------------N
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        ------------------------LADF-------------------------------E
7147_Tthe_STE11-Unclassified        ------------------------IRTV--------------------------------
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    ------------------------------------------------------------
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  ---------------------------E-------------------------------A
CC1G_10513_Ccin_STE11-Unclassified  ------------------------------------------------------------
AqueK224_Aque_ASK                   ------------------------------------------------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                --------------------------NLSGGIINVNC-----------------------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 ------------------------------------------------------------
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  ------------------------------------------------------------
MAP3K7_Hsap_ASK                     ------------------------------------------------------------
MAP3K6_Hsap_ASK                     ------------------------------------------------------------
MAP3K5_Hsap_ASK                     ------------------------------------------------------------
MAP3K4_Hsap_MEKK4                   AFVRDRAGFNGTSVEGQCKATPGTKIVGYST-----------------------------
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   ------------------------------------------------------------
MEKK15_Mmus_MEKK15                  E-----------------------------------------------------------
MAP3K7_Mmus_ASK                     ------------------------------------------------------------
MAP3K6_Mmus_ASK                     ------------------------------------------------------------
MAP3K5_Mmus_ASK                     ------------------------------------------------------------
MAP3K4_Mmus_MEKK4                   AFSSNGAGFNGPLVEGQCRTPQETNRVGCSS-----------------------------
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   ------------------------------------------------------------
nsy-1_Cele_ASK                      ------------------------------------------------------------
B0414.7_Cele_MEKK4                  E-----------------------------------------------------------
STE11_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK22_Scer_STE11-Unclassified       L-----------------------------------------------------------
SSK2_Scer_STE11-Unclassified        ------------------------------------------------------------
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ------------------------------------------------------------
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    D-----------------------------------------------------------
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       ------------------------------------------------------------
18758_Tthe_STE11-Unclassified       K-----------------------------------------------------------
23105_Tthe_STE11-Unclassified       I-----------------------------------------------------------
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        N-----------------------------------------------------------
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    S-SSSGS-----------------SSHGDSVETSQMNGNACDTCCNPNPVQRRHPSVSDN
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  A-----------------------------------------------------------
CC1G_10513_Ccin_STE11-Unclassified  ------------------------------------------------------------
AqueK224_Aque_ASK                   ------------------------------------------------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 E-----------------------------------------------------------
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  --------------------------KRVSLHKNEA------------------MEPN--
MAP3K7_Hsap_ASK                     -------------------SFDMANNV---------------------------------
MAP3K6_Hsap_ASK                     -------------------SFSMTNNV---------------------------------
MAP3K5_Hsap_ASK                     -------------------SFSMANNI---------------------------------
MAP3K4_Hsap_MEKK4                   ---------HHEHLQRQRVSFEQVKRI---------------------------------
MAP3K3_Hsap_MEKK2                   -------------------------------------------------------N--NE
MAP3K2_Hsap_MEKK2                   -------------------------------------------------------N--NE
MAP3K1_Hsap_MEKK1                   ----------------------------------------------------------G-
MEKK15_Mmus_MEKK15                  ---------------KEIGNENVPDAKSNSVHKSGAMEPHAASEEVSVPKNGPSVNSD--
MAP3K7_Mmus_ASK                     -------------------SFDMANNV---------------------------------
MAP3K6_Mmus_ASK                     -------------------SFSMTNNV---------------------------------
MAP3K5_Mmus_ASK                     -------------------SFSMANNI---------------------------------
MAP3K4_Mmus_MEKK4                   ---------YHEHLQRQRVSFEQVKRI---------------------------------
MAP3K3_Mmus_MEKK2                   -------------------------------------------------------N--NE
MAP3K2_Mmus_MEKK2                   -------------------------------------------------------N--NE
MAP3K1_Mmus_MEKK1                   ----------------------------------------------------------G-
nsy-1_Cele_ASK                      -------------------SMGQSYNM---------------------------------
B0414.7_Cele_MEKK4                  ---------------NLRDARKRVSDV---------------------------------
STE11_Scer_STE11-Unclassified       -----------------------------------------------------LLATNSN
SSK22_Scer_STE11-Unclassified       ---------------SLDALEAILQDL---------------------------------
SSK2_Scer_STE11-Unclassified        ---------------SADEAAETIKSL---------------------------------
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ------------------------------------------------------------
Pk92B_Dmel_ASK                      -------------------SFGMKENI---------------------------------
Mekk1_Dmel_MEKK4                    ---------------HQKLALREVEGM---------------------------------
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               -------------------GSGD-------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   -----------------------------------------------------ALT----
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       ------------------------------------------------------------
18758_Tthe_STE11-Unclassified       ---------------PQGFVEK--------------------------------------
23105_Tthe_STE11-Unclassified       ---------------IPSLIESPITKS---------------------------------
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        ---------------Q--------------------------------------------
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    ----------------------------------------------------------ND
MEKK2_Spur_MEKK2                    -------------------------------------------------------N--HN
MEKK4_Spur_MEKK4                    GFCMPLSAALNAYITDTSEAWYKVHAL---------------------------------
ASK_Spur_ASK                        -------------------SFGKEKNV---------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  ---------------PTNSAMKQVTNI---------------------------------
CC1G_10513_Ccin_STE11-Unclassified  ------------------------------------------------------------
AqueK224_Aque_ASK                   -------------------SFEMKQNI---------------------------------
AqueK225_Aque_MEKK1                 -------------------GNGCSVDV---------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------KNSE--
AqueK227_Aque_MEKK2                 -------------------RFTG-------------------------------------
AqueK228_Aque_MEKK4                 ---------------EQLQAIEDVDSL---------------------------------
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ----------------------------------------------------------DE
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  NIL---------------------------------------------------------
MAP3K7_Hsap_ASK                     ----------------------IL---YHDTDADT-------------------------
MAP3K6_Hsap_ASK                     ----------------------LL---CSQADLPD-------------------------
MAP3K5_Hsap_ASK                     ----------------------IL---YCDTNSDS-------------------------
MAP3K4_Hsap_MEKK4                   ----------------------MELLEYIEALYPSL------------------------
MAP3K3_Hsap_MEKK2                   ----LSILLKN-------------------------------------------------
MAP3K2_Hsap_MEKK2                   ----LVIPLTT-------------------------------------------------
MAP3K1_Hsap_MEKK1                   -----FSPYSPEETNRRVNKVMRARLYLLQQIGPNSFL----------------------
MEKK15_Mmus_MEKK15                  GPAEEL------------------------------------------------------
MAP3K7_Mmus_ASK                     ----------------------IL---YYDTDADT-------------------------
MAP3K6_Mmus_ASK                     ----------------------LL---CSQAELPD-------------------------
MAP3K5_Mmus_ASK                     ----------------------IL---YCDTNSDS-------------------------
MAP3K4_Mmus_MEKK4                   ----------------------MELLEYMEALYPSL------------------------
MAP3K3_Mmus_MEKK2                   ----LSILLKN-------------------------------------------------
MAP3K2_Mmus_MEKK2                   ----LVIPLTT-------------------------------------------------
MAP3K1_Mmus_MEKK1                   -----FSPYSPEETSRRVNKVMRARLYLLQQIGPNSFL----------------------
nsy-1_Cele_ASK                      ----------------------IL---TYWSPDPE-------------------------
B0414.7_Cele_MEKK4                  ----------------------LDKYETLVDLFPNQ------------------------
STE11_Scer_STE11-Unclassified       GE----------------------------------------------------------
SSK22_Scer_STE11-Unclassified       ----------------------MNRYHSVVSYWPNL------------------------
SSK2_Scer_STE11-Unclassified        ----------------------VDKYYRVLNLWPNI------------------------
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        --------------NSLSFDK----------------LI----------LSWDPTDPDEW
Pk92B_Dmel_ASK                      ----------------------LT---YNDIDSKQ-------------------------
Mekk1_Dmel_MEKK4                    ----------------------LTRLEAAEALYPSS------------------------
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       ------------------------------------------------------------
18758_Tthe_STE11-Unclassified       ------------------------------------------------------------
23105_Tthe_STE11-Unclassified       ----------------------SHNHNNHSNINGNF------------------------
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        ------------------------------------------------------------
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    ----CLFTLAVGVLKKRVERALHARLFLLTQSGPNSFL----------------------
MEKK2_Spur_MEKK2                    TTFSLLIPIRD-------------------------------------------------
MEKK4_Spur_MEKK4                    ----------------------LEDLEKVQLLYPNS------------------------
ASK_Spur_ASK                        ----------------------VL---YNDSVDPE-------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               --------DEAPSHKLNVFRK----------------VTFRGKSGQEPPATSNDGSQRPK
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------VST----------------P----------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  ----------------------LHRLDVAQSLYPHL------------------------
CC1G_10513_Ccin_STE11-Unclassified  --------KVPYSFSAVSSSI----------------L----------------------
AqueK224_Aque_ASK                   ----------------------VT---YLESGASG-------------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                GLTPLL------------------------------------------------------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 ----------------------LSDLERVELLYASS------------------------
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ----ES--LSG-------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  ------------------------------------------------------------
MAP3K7_Hsap_ASK                     ---------------------------ALSL----KDMVTQKNTAS-SGNYYFI------
MAP3K6_Hsap_ASK                     ---------------------------LQAL----REDVFQKNSDC-VGSYTLI------
MAP3K5_Hsap_ASK                     ---------------------------LQSL----KEIICQKNTMC-TGNYTFV------
MAP3K4_Hsap_MEKK4                   --------------------------QALQK----DYEKYAAKDFQDRVQALCLWLNITK
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   ------------------------------------------------------------
MEKK15_Mmus_MEKK15                  ------------------------------------------------------------
MAP3K7_Mmus_ASK                     ---------------------------ALSL----KDMVTQKNTAS-SGNYYFI------
MAP3K6_Mmus_ASK                     ---------------------------LQAL----REDVFQKNSDC-VGSYTLI------
MAP3K5_Mmus_ASK                     ---------------------------LQSL----KEIICQKNTVC-TGNYTFI------
MAP3K4_Mmus_MEKK4                   --------------------------QALQK----DYERYAAKDFEDRVQALCLWLNITK
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   ------------------------------------------------------------
nsy-1_Cele_ASK                      ---------------------------Y-HI----MDALK---K--THAHLPMI------
B0414.7_Cele_MEKK4                  --------------------------NALWKVVELDRGEAEKKLLEGRMTSMRVWLNTLD
STE11_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK22_Scer_STE11-Unclassified       --------------------------KKMYK----DKPITNTAEFTARIDVMNSWLNFKT
SSK2_Scer_STE11-Unclassified        --------------------------KRMHA----EKPITKTEAFRNRIDTLNSWLNFKF
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        TMHRVTSWF---------------------------------------------------
Pk92B_Dmel_ASK                      ------------------------------T----LSL-K----LS-CANYLFL------
Mekk1_Dmel_MEKK4                    --------------------------QAMGA----LHPIYKSQSFVGRIKSMCLWYNITK
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       ------------------------------------------------------------
18758_Tthe_STE11-Unclassified       --------------------------------------I----------RQLKNVNAKQV
23105_Tthe_STE11-Unclassified       --------------------------SSNDH----TSDL----------DKA--------
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        ---------------------------------------------------Q------NQ
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    --------------------------KALQN----DCVELSTPEFTKRLETLCLWMNITN
ASK_Spur_ASK                        -----------------------------GT----SSL-M---QSCHGSGYIFI------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ERVAGKTSFITPSMRQASMSSPALHLS---------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  --------------------------KAFYL----DKPKAQEGPFQARCDALNTWFTILS
CC1G_10513_Ccin_STE11-Unclassified  ------------------------------------------------------------
AqueK224_Aque_ASK                   -----------------------------GL----RGGAF---NP-KLTSYIYL------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 ---------------------------ITSL----RVVLSRQPVTI--------------
AqueK228_Aque_MEKK4                 --------------------------KRVVD------KQYQQLPFKRRRAALVLWLKITE
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  ------------------------------------------------------------
MAP3K7_Hsap_ASK                     ------------------------------------------------------------
MAP3K6_Hsap_ASK                     ------------------------------------------------------------
MAP3K5_Hsap_ASK                     ------------------------------------------------------------
MAP3K4_Hsap_MEKK4                   DLNQKLRIMGTV-LGIKNLSDIGWPVFEIPSPRPSKGN----EPEYEGDDTEGELKELES
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   ------------------------------------------------------------
MEKK15_Mmus_MEKK15                  ------------------------------------------------------------
MAP3K7_Mmus_ASK                     ------------------------------------------------------------
MAP3K6_Mmus_ASK                     ------------------------------------------------------------
MAP3K5_Mmus_ASK                     ------------------------------------------------------------
MAP3K4_Mmus_MEKK4                   DLNQKLRIMGTV-LGIKNLSDIGWPVFEIPSPRPSKGY----EPEDEVEDTEVELRELES
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   ------------------------------------------------------------
nsy-1_Cele_ASK                      ------------------------------------------------------------
B0414.7_Cele_MEKK4                  DLTDKFKALGVL-F-EIET-----------------------------------------
STE11_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK22_Scer_STE11-Unclassified       NLTLRRQELDDWI--NR-------------------------------------------
SSK2_Scer_STE11-Unclassified        NFDTNIAYLKKWIV-GNK------------------------------------------
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ----------------------------KFHDFPESWILFFKKHQLFGHRFIKLLAYDNF
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    QNKLKLSILGKI-L-ARLQDEKFSW-----------------------------------
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ----------------------QSS-----------------------------------
15684_Tthe_STE11-Unclassified       ----------------------NNK-----------------------------------
18758_Tthe_STE11-Unclassified       ENDQQQNIN---------------V-----------------------------------
23105_Tthe_STE11-Unclassified       --------NNSS-N-TNNGTISNIN-----------------------------------
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        NGEKIKTEQ---------------------------------------------------
7147_Tthe_STE11-Unclassified        ----------------------VSQ-----------------------------------
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    DISHKFELTSQI-LGVVDLEGLWWPYLDLPGYCVENPFQSESCIESEMDDEVKPMNEFDD
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------SQALPSPKSQSAVP----------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  -------------------------------EPGITHA----------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  SLKRHLTRLRRW-T-GSD------------------------------------------
CC1G_10513_Ccin_STE11-Unclassified  -------------------------------TRHQTNL----------------------
AqueK224_Aque_ASK                   ------------------------------------------------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 GLAKHLVNLSKW-F-GVIV-----------------------------------------
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  ------------------------------------------------------------
MAP3K7_Hsap_ASK                     ------------------------------------------------------------
MAP3K6_Hsap_ASK                     ------------------------------------------------------------
MAP3K5_Hsap_ASK                     ------------------------------------------------------------
MAP3K4_Hsap_MEKK4                   STDESEEE------QISDPRVP--------EIRQPIDNSFDIQSRDCISKKLERLESEDD
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   ------------------------------------------------------------
MEKK15_Mmus_MEKK15                  ------------------------------------------------------------
MAP3K7_Mmus_ASK                     ------------------------------------------------------------
MAP3K6_Mmus_ASK                     ------------------------------------------------------------
MAP3K5_Mmus_ASK                     ------------------------------------------------------------
MAP3K4_Mmus_MEKK4                   GTEESDEE------PTPSPRVP--------ELRLSTDAILDSRSQGCVSRKLERLESEED
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   ------------------------------------------------------------
nsy-1_Cele_ASK                      ------------------------------------------------------------
B0414.7_Cele_MEKK4                  ------------------------------------------------------------
STE11_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK22_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK2_Scer_STE11-Unclassified        ------------------------------------------------------------
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        AVYEKYLPQTKTASYTRFQQLLKKTMTKNVTNSHIRQKSASKLKS---------------
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    ------------------------------------------------------------
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       ------------------------------------------------------------
18758_Tthe_STE11-Unclassified       ------------------------------------------------------------
23105_Tthe_STE11-Unclassified       ------------------------------------------------------------
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        ------------------------------------------------------------
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    ST-----PNLEGTEQPALTSTPQYRSPRTDES----------------------------
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               --------------------------------------------ASSSSNADVLVS----
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  --------------------------------------------LKRIYMG---------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10513_Ccin_STE11-Unclassified  --------------------------------------------LDGLNRYSIYLTEIGA
AqueK224_Aque_ASK                   ------------------------------------------------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 ------------------------------------------------------------
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  ------------------------------------------------------------
MAP3K7_Hsap_ASK                     ------------------------------------------------------------
MAP3K6_Hsap_ASK                     ------------------------------------------------------------
MAP3K5_Hsap_ASK                     ------------------------------------------------------------
MAP3K4_Hsap_MEKK4                   SLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLRKLILRLHKLMDGSLQRARIALV
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   --IGG-------------------------------------------------------
MEKK15_Mmus_MEKK15                  ------------------------------------------------------------
MAP3K7_Mmus_ASK                     ------------------------------------------------------------
MAP3K6_Mmus_ASK                     ------------------------------------------------------------
MAP3K5_Mmus_ASK                     ------------------------------------------------------------
MAP3K4_Mmus_MEKK4                   SIG--WGTADCGPEASRHCLTSIYRPFVDKALKQMGLRKLILRLHKLMNGSLQRARVALV
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   --IGG-------------------------------------------------------
nsy-1_Cele_ASK                      ------------------------------------------------------------
B0414.7_Cele_MEKK4                  ------------------------------------------------------------
STE11_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK22_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK2_Scer_STE11-Unclassified        ------------------------------------------------------------
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        ---------SRSSSESIKSKLKNSKSQEDISNSRSTSESALSPTKSGPSKTDEKNFLHST
Pk92B_Dmel_ASK                      ------------------------------------------------------------
Mekk1_Dmel_MEKK4                    ------------------------------------PVCTSSYIATDSGSSSASGVENDD
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------QKNVIVQ-AN--------------
15684_Tthe_STE11-Unclassified       ------------------------------------QEETIVP-T---------------
18758_Tthe_STE11-Unclassified       ------------------------------------NN----------------------
23105_Tthe_STE11-Unclassified       ------------------------------------ISNIQIMN-NSSSNNNTNSNQNGN
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        ------------------------------------------------------------
7147_Tthe_STE11-Unclassified        ------------------------------------LKELIFIIYT--------------
MEKK1_Spur_MEKK1                    --IGG-------------------------------------------------------
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    -PRTNRIFSECHFSFDYDSSTSIYRPFVDRSLKHQGLRKMTKRLDKMLGHTMRKIRLALE
ASK_Spur_ASK                        ------------------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ------------------------------------------------------------
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10513_Ccin_STE11-Unclassified  SVIGDPLNDERLLDLVQRQGDSRGTLKFFVSRSTKEQIPPPPQQMPPPFPFPYVEQPTHP
AqueK224_Aque_ASK                   ------------------------------------------------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 ------------------------------------------------------------
AqueK228_Aque_MEKK4                 ------------------------------------------------------------
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  ------------------------------------------------------------
MAP3K7_Hsap_ASK                     -----------------------------------PYIV---------------------
MAP3K6_Hsap_ASK                     -----------------------------------PYVV---------------------
MAP3K5_Hsap_ASK                     -----------------------------------PYMI---------------------
MAP3K4_Hsap_MEKK4                   KN--DRPVEFSEFPDPMWGSDY------------VQLSR---------------------
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   ------------------------------------------------------------
MEKK15_Mmus_MEKK15                  ------------------------------------------------------------
MAP3K7_Mmus_ASK                     -----------------------------------PYTV---------------------
MAP3K6_Mmus_ASK                     -----------------------------------PYVV---------------------
MAP3K5_Mmus_ASK                     -----------------------------------PYMV---------------------
MAP3K4_Mmus_MEKK4                   KD--DRPVEFSDFPGPMWGSDY------------VQLSG---------------------
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   ------------------------------------------------------------
nsy-1_Cele_ASK                      -----------------------------------VYIH---------------------
B0414.7_Cele_MEKK4                  -----MPDAEECWFRPL------------DE-----------------------------
STE11_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK22_Scer_STE11-Unclassified       -----FSP-ISSSDNCQEDF--------------------------------------DG
SSK2_Scer_STE11-Unclassified        ----ELES-TTEVDNTTVNL--------------------------------------DD
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        STHQKTKSASSLYRRSFISLRGSSSSNASSAKSPSNIKLSIPARPHSIIESNSTLTKSAS
Pk92B_Dmel_ASK                      -----------------------------------SYKR---------------------
Mekk1_Dmel_MEKK4                    SAVNS-------MDSSKPPSMAGSASRKGVTPCHKVQFMLNDATHVPGETSSSNESTSTE
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       ------------------------------------------------------------
18758_Tthe_STE11-Unclassified       ------------------------------------------------------------
23105_Tthe_STE11-Unclassified       SSSQN-------YNNSNNQNQNNSISSSFQNIGGHQNNFPISTESNRNSINNLSSINNNN
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        ------------------------------------------------------------
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    KMKLDTLIEFMDHKCPMWYSLQSDIDLTLKPSGTPQFFE---------------------
ASK_Spur_ASK                        -----------------------------------PYKM---------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               ---PTRPRTRRVSMQPAPPKEISAPSLPSPRTTAQGPTRHRSSKSVPVAIPPSPSSPSLP
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_13687_Ccin_STE11-Unclassified  ----SLDVNHPNPNSEITVT--------------------------------------SQ
CC1G_10513_Ccin_STE11-Unclassified  AILPLRPR----------------------------------------------------
AqueK224_Aque_ASK                   -----------------------------------PYSV---------------------
AqueK225_Aque_MEKK1                 ------------------------------------------------------------
AqueK226_Aque_MEKK15                ------------------------------------------------------------
AqueK227_Aque_MEKK2                 --------------------------------------T---------------------
AqueK228_Aque_MEKK4                 -----NP---------VRRSEDDLIPCNVEPGTPSRQGSGGSGGNPPLPTPPLFTSDISV
MEKK2-p1_a_Smoe_MEKK2-plant1        ------------------------------------------------------------
MEKK2-p1_b_Smoe_MEKK2-plant1        ------------------------------------------------------------
STE11-p2_b-2_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_a_Smoe_MEKK2-plant2        ------------------------------------------------------------
STE11-p2_b-1_Smoe_MEKK2-plant2      ------------------------------------------------------------
STE11-p2_h_Smoe_MEKK2-plant2        ------------------------------------------------------------
NPK1-2_Smoe_NPK1                    ------------------------------------------------------------
NPK1-1_Smoe_NPK1                    ------------------------------------------------------------
STE11-p2_e-2_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_j_Smoe_STE11-plant1        ------------------------------------------------------------
STE11-p2_e-1_Smoe_STE11-plant1      ------------------------------------------------------------
STE11-p2_g_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_c_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_f_Smoe_STE11-plant2        ------------------------------------------------------------
STE11-p2_d-1_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p2_d-2_Smoe_STE11-plant2      ------------------------------------------------------------
STE11-p3-1_Smoe_STE11-plant3        ------------------------------------------------------------
STE11-p3-2_Smoe_STE11-plant3        ------------------------------------------------------------
GK076_Glam_CDC15                    ------------------------------------------------------------
GK077_Glam_CDC15                    ------------------------------------------------------------
GK078_Glam_STE11-Unclassified       ------------------------------------------------------------


MEKK15_Hsap_MEKK15                  ------------------------------------------------------------
MAP3K7_Hsap_ASK                     -----------T------------------------------------------------
MAP3K6_Hsap_ASK                     -----------T------------------------------------------------
MAP3K5_Hsap_ASK                     -----------T------------------------------------------------
MAP3K4_Hsap_MEKK4                   -----------T------------------------------------------------
MAP3K3_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K2_Hsap_MEKK2                   ------------------------------------------------------------
MAP3K1_Hsap_MEKK1                   ------------------------------------------------------------
MEKK15_Mmus_MEKK15                  ------------------------------------------------------------
MAP3K7_Mmus_ASK                     -----------T------------------------------------------------
MAP3K6_Mmus_ASK                     -----------T------------------------------------------------
MAP3K5_Mmus_ASK                     -----------T------------------------------------------------
MAP3K4_Mmus_MEKK4                   -----------T------------------------------------------------
MAP3K3_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K2_Mmus_MEKK2                   ------------------------------------------------------------
MAP3K1_Mmus_MEKK1                   ------------------------------------------------------------
nsy-1_Cele_ASK                      -----------H------------------------------------------------
B0414.7_Cele_MEKK4                  ------------------------------------NNKIFALE---DVRAVFLEYVKNS
STE11_Scer_STE11-Unclassified       ------------------------------------------------------------
SSK22_Scer_STE11-Unclassified       VPQW-------------------------------------N--------CKMKILAEQL
SSK2_Scer_STE11-Unclassified        PAVF-------------------------------------A--------TNCKRFAEQI
CDC15_Scer_CDC15                    ------------------------------------------------------------
BCK1_Scer_STE11-Unclassified        PPASPSYPSIFRRHHKSSSSESSLLNSLFGSGIGEEAPTKPN--------PQGHSLSSEN
Pk92B_Dmel_ASK                      -----------N------------------------------------------------
Mekk1_Dmel_MEKK4                    VSQWSSECSHSHMRKGSMHDINIFSVEPLGTCSSNGTGEQST--------GLYRKFIENV
DDB0229877_Ddis_CDC15               ------------------------------------------------------------
DDB0229896_Ddis_CDC15               ------------------------------------------------------------
DDB0229915_Ddis_CDC15               ------------------------------------------------------------
DDB0229971_Ddis_CDC15               ------------------------------------------------------------
DDB0231212_Ddis_CDC15               ------------------------------------------------------------
MEKKalpha_Ddis_STE11-Unclassified   ------------------------------------------------------------
11359_Tthe_STE11-Unclassified       ------------------------------------------------------------
15684_Tthe_STE11-Unclassified       ------------------------------------------------------------
18758_Tthe_STE11-Unclassified       -----------------------------------------------------------S
23105_Tthe_STE11-Unclassified       NINNSCSNTNHNNKSNLSSYKRQEKKYRISKTQILFPFNSKE--------NICDPESQNA
29763_Tthe_STE11-Unclassified       ------------------------------------------------------------
4322_Tthe_CDC15                     ------------------------------------------------------------
6622_Tthe_STE11-Unclassified        --------------------------NKIDNEGQFQVQN-EE--------EQISPIK--N
7147_Tthe_STE11-Unclassified        ------------------------------------------------------------
MEKK1_Spur_MEKK1                    ------------------------------------------------------------
MEKK2_Spur_MEKK2                    ------------------------------------------------------------
MEKK4_Spur_MEKK4                    -----------T------------------------------------------------
ASK_Spur_ASK                        -----------D------------------------------------------------
MEKK15_Spur_MEKK15                  ------------------------------------------------------------
CC1G_00852_Ccin_CDC15               STSSESPVPTRVRHVPASPSHSPTPYSTSRVTPIRSPSKTSG--------SATPRASSPA
CC1G_05008_Ccin_CDC15               ------------------------------------------------------------
CC1G_12014_Ccin_STE11-Unclassified  ------------------------------------------------------------
CC1G_10524_Ccin_STE11-Unclassified  ----------------