Kinase Subfamily NEK8

Kinase Classification: Group Other: Family NEK: Subfamily NEK8

Evolution

NEK8 is found in most holozoans (animals + choanoflagellates). It has a single copy in mammals (NEK8) and Drosophila (CG10951) but has duplicated in C. elegans (nekl-1/ZC581.1, nekl-2/Y39G10AR.4), sea urchin, sponge and elsewhere.

Domain Structure

Like NEK9, members have an N-terminal kinase domain followed by a set of 7 RCC1 (regulator of chromosome condensation) domains. Many invertebrate have an additional N-terminal domain that is lost in bony vertebrates.