Kinase Family CCK4

Kinase Classification: Group TK: Family CCK4

DDR: Discoidin Domain Receptors

These receptor tyrosine kinases uniquely recognize and signal downstream of extracellular collagen.

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Evolution

TAMs are vertebrate-specific, with three members in tetrapods and four in most fish. A possible TAM has been seen in the invertebrate chordate, Ciona intestinalis.

Domain Structure

TAMS are single-pass transmembrane proteins, with extracellular Ig and FN3 domains, and an intracellular tyrosine kinase domain.

References

1. Exposito JY, Larroux C, Cluzel C, Valcourt U, Lethias C, and Degnan BM. Demosponge and sea anemone fibrillar collagen diversity reveals the early emergence of A/C clades and the maintenance of the modular structure of type V/XI collagens from sponge to human. J Biol Chem. 2008 Oct 17;283(42):28226-35. DOI:10.1074/jbc.M804573200 |