Difference between revisions of "Kinase Family GASK"
From WikiKinome
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The FJ kinases are a recently-emerging family of atypical PKL-fold kinases which function in the Golgi to phosphorylate secreted proteins and sugar residues on glycoproteins and are sometimes secreted. The founding member, Drosophila <I>four-jointed</I> phosphorylates a cadherin substrate on the extracellular domain and is implicated in planar cell polarity. | The FJ kinases are a recently-emerging family of atypical PKL-fold kinases which function in the Golgi to phosphorylate secreted proteins and sugar residues on glycoproteins and are sometimes secreted. The founding member, Drosophila <I>four-jointed</I> phosphorylates a cadherin substrate on the extracellular domain and is implicated in planar cell polarity. | ||
| − | Distinct subfamilies, [[Kinase_Subfamily_FJ]], [[FAM20AC]] and [[FAM20B]] are found in bilaterian animals and some in lower animals, and unclassified homologs have also been found in Trypanosomes. | + | Distinct subfamilies, [[Kinase_Subfamily_FJ|FJ]], [[Kinase_Subfamily_FAM20AC|FAM20AC]] and [[Kinase_Subfamily_FAM20B|FAM20B]] are found in bilaterian animals and some in lower animals, and unclassified homologs have also been found in Trypanosomes. |
Revision as of 20:00, 10 September 2010
Kinase Classification: Group Atypical: Family FJ
The FJ kinases are a recently-emerging family of atypical PKL-fold kinases which function in the Golgi to phosphorylate secreted proteins and sugar residues on glycoproteins and are sometimes secreted. The founding member, Drosophila four-jointed phosphorylates a cadherin substrate on the extracellular domain and is implicated in planar cell polarity.
Distinct subfamilies, FJ, FAM20AC and FAM20B are found in bilaterian animals and some in lower animals, and unclassified homologs have also been found in Trypanosomes.
