Kinase Family GASK

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Kinase Classification: Group Atypical: Family FJ

The FJ kinases are a recently-emerging family of atypical PKL-fold kinases which function in the Golgi to phosphorylate secreted proteins and sugar residues on glycoproteins and are sometimes secreted. The founding member, Drosophila four-jointed phosphorylates a cadherin substrate on the extracellular domain and is implicated in planar cell polarity.

Distinct subfamilies, FJ, FAM20AC and FAM20B are found in bilaterian animals and some in lower animals, and unclassified homologs have also been found in Trypanosomes.